Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc413_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 28 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043130 ubiquitin binding 3.723E-6 8.492E-5 3.335E-4 1.042E-4 3 108
2 GO:0032182 ubiquitin-like protein binding 6.066E-6 8.492E-5 3.335E-4 1.698E-4 3 127
3 GO:0030305 heparanase activity 6.430E-4 4.814E-3 1.891E-2 1.800E-2 1 2
4 GO:1901981 phosphatidylinositol phosphate binding 6.877E-4 4.814E-3 1.891E-2 1.926E-2 2 128
5 GO:0004566 beta-glucuronidase activity 1.286E-3 7.199E-3 2.827E-2 3.600E-2 1 4
6 GO:0045545 syndecan binding 1.928E-3 7.831E-3 3.076E-2
5.398E-2
 1 6
7 GO:0035091 phosphatidylinositol binding 1.958E-3 7.831E-3 3.076E-2
5.482E-2
 2 217
8 GO:0046790 virion binding 3.532E-3 1.199E-2 4.707E-2
9.890E-2
 1 11
9 GO:1990381 ubiquitin-specific protease binding 3.853E-3 1.199E-2 4.707E-2
1.079E-1
 1 12
10 GO:0005543 phospholipid binding 6.028E-3 1.688E-2
6.628E-2
1.688E-1
 2 385
11 GO:0031210 phosphatidylcholine binding 7.373E-3 1.877E-2
7.371E-2
2.065E-1
 1 23
12 GO:0032266 phosphatidylinositol-3-phosphate binding 1.025E-2 2.391E-2
9.389E-2
2.869E-1
 1 32
13 GO:0030374 nuclear receptor transcription coactivator activity 1.724E-2 3.448E-2
1.354E-1
4.827E-1
 1 54
14 GO:0050997 quaternary ammonium group binding 1.724E-2 3.448E-2
1.354E-1
4.827E-1
 1 54
15 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1.882E-2 3.514E-2
1.380E-1
5.271E-1
 1 59
16 GO:0048306 calcium-dependent protein binding 2.230E-2 3.902E-2
1.533E-1
6.244E-1
 1 70
17 GO:0070405 ammonium ion binding 2.514E-2 4.057E-2
1.593E-1
7.038E-1
 1 79
18 GO:1902936 phosphatidylinositol bisphosphate binding 2.608E-2 4.057E-2
1.593E-1
7.303E-1
 1 82
19 GO:0043178 alcohol binding 3.548E-2 4.938E-2
1.939E-1
9.934E-1
 1 112
20 GO:0002020 protease binding 3.642E-2 4.938E-2
1.939E-1
1.000E0
 1 115
21 GO:0047485 protein N-terminus binding 3.704E-2 4.938E-2
1.939E-1
1.000E0
 1 117
Show 16 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 179 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0036258 multivesicular body assembly 4.578E-14 4.885E-12 2.817E-11 8.194E-12 5 30
2 GO:0036257 multivesicular body organization 5.458E-14 4.885E-12 2.817E-11 9.770E-12 5 31
3 GO:0007032 endosome organization 2.866E-12 1.710E-10 9.863E-10 5.131E-10 5 66
4 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 1.159E-11 5.186E-10 2.991E-9 2.075E-9 4 19
5 GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway 7.432E-11 2.217E-9 1.279E-8 1.330E-8 3 4
6 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway 7.432E-11 2.217E-9 1.279E-8 1.330E-8 3 4
7 GO:0032509 endosome transport via multivesicular body sorting pathway 1.040E-9 2.659E-8 1.534E-7 1.862E-7 3 8
8 GO:0007033 vacuole organization 1.191E-9 2.666E-8 1.537E-7 2.133E-7 5 216
9 GO:0016197 endosomal transport 2.970E-9 5.908E-8 3.407E-7 5.317E-7 5 259
10 GO:0007034 vacuolar transport 5.063E-9 9.063E-8 5.227E-7 9.063E-7 5 288
11 GO:0045324 late endosome to vacuole transport 6.755E-9 1.099E-7 6.340E-7 1.209E-6 3 14
12 GO:0039702 viral budding via host ESCRT complex 2.855E-8 4.259E-7 2.456E-6 5.111E-6 3 22
13 GO:0046755 viral budding 4.263E-8 5.450E-7 3.143E-6 7.630E-6 3 25
14 GO:1902590 multi-organism organelle organization 4.263E-8 5.450E-7 3.143E-6 7.630E-6 3 25
15 GO:2000395 regulation of ubiquitin-dependent endocytosis 8.651E-8 9.671E-7 5.578E-6 1.548E-5 2 2
16 GO:2000397 positive regulation of ubiquitin-dependent endocytosis 8.651E-8 9.671E-7 5.578E-6 1.548E-5 2 2
17 GO:0044803 multi-organism membrane organization 9.185E-8 9.671E-7 5.578E-6 1.644E-5 3 32
18 GO:0006623 protein targeting to vacuole 1.108E-7 1.102E-6 6.354E-6 1.983E-5 3 34
19 GO:0072666 establishment of protein localization to vacuole 1.212E-7 1.141E-6 6.583E-6 2.169E-5 3 35
20 GO:0019068 virion assembly 1.561E-7 1.397E-6 8.058E-6 2.794E-5 3 38
21 GO:0072665 protein localization to vacuole 4.327E-7 3.688E-6 2.127E-5 7.745E-5 3 53
22 GO:0070086 ubiquitin-dependent endocytosis 5.189E-7 4.222E-6 2.435E-5 9.288E-5 2 4
23 GO:0019058 viral life cycle 4.729E-6 3.680E-5 2.122E-4 8.464E-4 4 447
24 GO:0006900 vesicle budding from membrane 5.275E-6 3.935E-5 2.269E-4 9.443E-4 3 121
25 GO:1902188 positive regulation of viral release from host cell 9.066E-6 6.491E-5 3.744E-4 1.623E-3 2 15
26 GO:1903541 regulation of exosomal secretion 1.174E-5 8.082E-5 4.661E-4 2.101E-3 2 17
27 GO:1903900 regulation of viral life cycle 1.625E-5 1.078E-4 6.215E-4 2.909E-3 3 176
28 GO:1990182 exosomal secretion 1.812E-5 1.158E-4 6.680E-4 3.243E-3 2 21
29 GO:0050792 regulation of viral process 2.012E-5 1.242E-4 7.162E-4 3.601E-3 3 189
30 GO:0043903 regulation of symbiosis, encompassing mutualism through parasitism 3.168E-5 1.890E-4 1.090E-3 5.671E-3 3 220
31 GO:0097352 autophagosome maturation 3.499E-5 2.020E-4 1.165E-3 6.262E-3 2 29
32 GO:0097576 vacuole fusion 4.272E-5 2.317E-4 1.337E-3 7.647E-3 2 32
33 GO:1902186 regulation of viral release from host cell 4.272E-5 2.317E-4 1.337E-3 7.647E-3 2 32
34 GO:0019076 viral release from host cell 5.423E-5 2.855E-4 1.647E-3 9.708E-3 2 36
35 GO:0008333 endosome to lysosome transport 9.291E-5 4.752E-4 2.741E-3 1.663E-2 2 47
36 GO:0016050 vesicle organization 1.294E-4 6.436E-4 3.712E-3 2.317E-2 3 353
37 GO:1902583 multi-organism intracellular transport 1.895E-4 8.926E-4 5.148E-3 3.392E-2 2 67
38 GO:0075733 intracellular transport of virus 1.895E-4 8.926E-4 5.148E-3 3.392E-2 2 67
39 GO:0046794 transport of virus 2.069E-4 9.293E-4 5.360E-3 3.703E-2 2 70
40 GO:0044766 multi-organism transport 2.129E-4 9.293E-4 5.360E-3 3.810E-2 2 71
41 GO:1902579 multi-organism localization 2.129E-4 9.293E-4 5.360E-3 3.810E-2 2 71
42 GO:0007041 lysosomal transport 2.570E-4 1.095E-3 6.316E-3 4.600E-2 2 78
43 GO:1903902 positive regulation of viral life cycle 3.197E-4 1.331E-3 7.675E-3
5.723E-2
 2 87
44 GO:0048524 positive regulation of viral process 3.732E-4 1.518E-3 8.755E-3
6.680E-2
 2 94
45 GO:0030200 heparan sulfate proteoglycan catabolic process 6.443E-4 2.563E-3 1.478E-2
1.153E-1
 1 2
46 GO:0045807 positive regulation of endocytosis 7.564E-4 2.943E-3 1.698E-2
1.354E-1
 2 134
47 GO:0030167 proteoglycan catabolic process 9.663E-4 3.603E-3 2.078E-2
1.730E-1
 1 3
48 GO:1903774 positive regulation of viral budding via host ESCRT complex 9.663E-4 3.603E-3 2.078E-2
1.730E-1
 1 3
49 GO:1902115 regulation of organelle assembly 1.143E-3 4.177E-3 2.409E-2
2.047E-1
 2 165
50 GO:0043902 positive regulation of multi-organism process 1.185E-3 4.242E-3 2.447E-2
2.121E-1
 2 168
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 18 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0036452 ESCRT complex 1.882E-14 3.387E-13 1.184E-12 3.387E-13 5 26
2 GO:0031902 late endosome membrane 1.449E-8 1.304E-7 4.559E-7 2.609E-7 4 108
3 GO:0010008 endosome membrane 2.312E-8 1.387E-7 4.849E-7 4.162E-7 5 399
4 GO:0044440 endosomal part 3.522E-8 1.585E-7 5.540E-7 6.340E-7 5 434
5 GO:0000814 ESCRT II complex 2.477E-7 8.204E-7 2.867E-6 4.458E-6 2 3
6 GO:0005770 late endosome 2.735E-7 8.204E-7 2.867E-6 4.922E-6 4 224
7 GO:0000813 ESCRT I complex 2.970E-6 7.637E-6 2.669E-5 5.346E-5 2 9
8 GO:0005769 early endosome 8.536E-5 1.921E-4 6.713E-4 1.536E-3 3 314
9 GO:0000815 ESCRT III complex 3.458E-3 6.916E-3 2.417E-2
6.224E-2
 1 11
10 GO:0005771 multivesicular body 1.439E-2 2.591E-2
9.056E-2
2.591E-1
 1 46
11 GO:0043202 lysosomal lumen 2.739E-2 4.481E-2
1.566E-1
4.930E-1
 1 88
Show 6 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 9 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 94 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 6 input genes in category / 36 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS51495 GLUE PROSITE 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
2 1.10.10.570 - Gene3D 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
3 IPR017899 VPS28 C InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
4 IPR007143 VPS28 InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
5 IPR017898 VPS28 N InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
6 IPR008570 ESCRT-II cplx vps25-sub InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
7 PF09454 Vps23 core Pfam 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
8 PF03997 VPS28 Pfam 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
9 PS51313 VPS28 N PROSITE 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
10 PF05871 ESCRT-II Pfam 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
11 IPR017916 SB dom InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
12 IPR014041 ESCRT-II cplx Vps25-sub N InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
13 PS51312 SB PROSITE 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
14 IPR021648 GLUE dom InterPro 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
15 PS51310 VPS28 C PROSITE 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
16 PF11605 Vps36 ESCRT-II Pfam 3.203E-4 7.206E-4 3.008E-3 1.153E-2 1 1
17 IPR005199 Glyco hydro 79 InterPro 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
18 IPR007286 EAP30 InterPro 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
19 PF04157 EAP30 Pfam 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
20 PS51322 UEV PROSITE 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
21 PF03662 Glyco hydro 79n Pfam 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
22 IPR008883 UEV N InterPro 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
23 PF05743 UEV Pfam 6.404E-4 1.002E-3 4.185E-3 2.306E-2 1 2
24 1.10.10.10 - Gene3D 1.960E-3 2.941E-3 1.228E-2
7.057E-2
 2 218
25 IPR011991 WHTH DNA-bd dom InterPro 2.428E-3 3.497E-3 1.460E-2
8.742E-2
 2 243
26 IPR005024 Snf7 fam InterPro 3.837E-3 5.117E-3 2.136E-2
1.381E-1
 1 12
27 PF03357 Snf7 Pfam 3.837E-3 5.117E-3 2.136E-2
1.381E-1
 1 12
28 3.20.20.80 - Gene3D 1.116E-2 1.435E-2
5.989E-2
4.017E-1
 1 35
29 IPR013781 Glyco hydro catalytic dom InterPro 1.211E-2 1.469E-2
6.134E-2
4.360E-1
 1 38
30 PS00183 UBIQUITIN CONJUGAT 1 PROSITE 1.274E-2 1.469E-2
6.134E-2
4.588E-1
 1 40
31 PS50127 UBIQUITIN CONJUGAT 2 PROSITE 1.306E-2 1.469E-2
6.134E-2
4.702E-1
 1 41
32 IPR000608 UBQ-conjugat E2 InterPro 1.306E-2 1.469E-2
6.134E-2
4.702E-1
 1 41
33 3.10.110.10 - Gene3D 1.622E-2 1.734E-2
7.238E-2
5.841E-1
 1 51
34 IPR017853 Glycoside hydrolase SF InterPro 1.686E-2 1.734E-2
7.238E-2
6.068E-1
 1 53
35 IPR016135 UBQ-conjugating enzyme/RWD InterPro 1.686E-2 1.734E-2
7.238E-2
6.068E-1
 1 53
Show 30 more annotations

7: Pathway [Display Chart] 6 input genes in category / 24 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269895 Endosomal Sorting Complex Required For Transport (ESCRT) BioSystems: REACTOME 2.364E-13 5.673E-12 2.142E-11 5.673E-12 5 28
2 102279 Endocytosis BioSystems: KEGG 2.255E-8 2.707E-7 1.022E-6 5.413E-7 5 260
3 1269090 Budding and maturation of HIV virion BioSystems: REACTOME 1.425E-7 1.140E-6 4.304E-6 3.420E-6 3 25
4 1269088 Membrane binding and targetting of GAG proteins BioSystems: REACTOME 1.063E-5 5.100E-5 1.926E-4 2.550E-4 2 11
5 1269087 Synthesis And Processing Of GAG, GAGPOL Polyproteins BioSystems: REACTOME 1.063E-5 5.100E-5 1.926E-4 2.550E-4 2 11
6 1269086 Assembly Of The HIV Virion BioSystems: REACTOME 1.506E-5 6.025E-5 2.275E-4 3.615E-4 2 13
7 1269069 Late Phase of HIV Life Cycle BioSystems: REACTOME 2.774E-5 9.511E-5 3.591E-4 6.658E-4 3 141
8 1269058 HIV Life Cycle BioSystems: REACTOME 3.612E-5 1.084E-4 4.092E-4 8.669E-4 3 154
9 138013 Internalization of ErbB1 BioSystems: Pathway Interaction Database 1.078E-4 2.876E-4 1.086E-3 2.588E-3 2 34
10 1269057 HIV Infection BioSystems: REACTOME 1.355E-4 3.253E-4 1.228E-3 3.253E-3 3 240
11 1269056 Infectious disease BioSystems: REACTOME 5.815E-4 1.269E-3 4.791E-3 1.396E-2 3 393
12 413377 Heparan sulfate degradation BioSystems: KEGG 4.330E-3 8.661E-3 3.270E-2
1.039E-1
 1 9
13 138046 Syndecan-1-mediated signaling events BioSystems: Pathway Interaction Database 8.166E-3 1.508E-2
5.693E-2
1.960E-1
 1 17
14 82981 Glycosaminoglycan degradation BioSystems: KEGG 9.124E-3 1.564E-2
5.906E-2
2.190E-1
 1 19
15 1269983 HS-GAG degradation BioSystems: REACTOME 1.008E-2 1.613E-2
6.090E-2
2.419E-1
 1 21
16 1269980 Heparan sulfate/heparin (HS-GAG) metabolism BioSystems: REACTOME 2.575E-2 3.862E-2
1.458E-1
6.180E-1
 1 54
17 1270432 Macroautophagy BioSystems: REACTOME 3.186E-2 4.498E-2
1.699E-1
7.647E-1
 1 67
Show 12 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 727 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14519844 Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins. Pubmed 7.591E-17 2.759E-14 1.977E-13 5.518E-14 5 18
2 14505570 The protein network of HIV budding. Pubmed 7.591E-17 2.759E-14 1.977E-13 5.518E-14 5 18
3 20588296 Membrane budding and scission by the ESCRT machinery: it's all in the neck. Pubmed 1.052E-15 2.549E-13 1.827E-12 7.647E-13 5 29
4 15218037 The human endosomal sorting complex required for transport (ESCRT-I) and its role in HIV-1 budding. Pubmed 3.553E-14 6.457E-12 4.628E-11 2.583E-11 4 10
5 11031247 Secretory protein trafficking and organelle dynamics in living cells. Pubmed 2.902E-13 4.219E-11 3.024E-10 2.110E-10 5 85
6 18539118 Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Pubmed 8.616E-12 8.948E-10 6.413E-9 6.264E-9 3 4
7 26268989 Evidence that the endosomal sorting complex required for transport-II (ESCRT-II) is required for efficient human immunodeficiency virus-1 (HIV-1) production. Pubmed 8.616E-12 8.948E-10 6.413E-9 6.264E-9 3 4
8 21543492 Sprouty 2 binds ESCRT-II factor Eap20 and facilitates HIV-1 gag release. Pubmed 2.154E-11 1.957E-9 1.403E-8 1.566E-8 3 5
9 16973552 Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release. Pubmed 7.538E-11 5.480E-9 3.927E-8 5.480E-8 3 7
10 23027949 In vitro reconstitution of the ordered assembly of the endosomal sorting complex required for transport at membrane-bound HIV-1 Gag clusters. Pubmed 7.538E-11 5.480E-9 3.927E-8 5.480E-8 3 7
11 23305486 Wrapping up the bad news: HIV assembly and release. Pubmed 1.756E-9 1.161E-7 8.318E-7 1.277E-6 3 18
12 17215868 Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. Pubmed 2.057E-8 1.068E-6 7.654E-6 1.495E-5 2 2
13 11134028 TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. Pubmed 2.057E-8 1.068E-6 7.654E-6 1.495E-5 2 2
14 12663786 Role of ESCRT-I in retroviral budding. Pubmed 2.057E-8 1.068E-6 7.654E-6 1.495E-5 2 2
15 16778200 Bcr interacts with components of the endosomal sorting complex required for transport-I and is required for epidermal growth factor receptor turnover. Pubmed 6.170E-8 2.243E-6 1.607E-5 4.485E-5 2 3
16 18077552 Regulation of Tsg101 expression by the steadiness box: a role of Tsg101-associated ligase. Pubmed 6.170E-8 2.243E-6 1.607E-5 4.485E-5 2 3
17 20427536 Human immunodeficiency virus type 1 nucleocapsid p1 confers ESCRT pathway dependence. Pubmed 6.170E-8 2.243E-6 1.607E-5 4.485E-5 2 3
18 17982468 Beyond Tsg101: the role of Alix in 'ESCRTing' HIV-1. Pubmed 6.170E-8 2.243E-6 1.607E-5 4.485E-5 2 3
19 16554368 The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor. Pubmed 6.170E-8 2.243E-6 1.607E-5 4.485E-5 2 3
20 11278625 Cloning and characterization of ELL-associated proteins EAP45 and EAP20. a role for yeast EAP-like proteins in regulation of gene expression by glucose. Pubmed 6.170E-8 2.243E-6 1.607E-5 4.485E-5 2 3
21 16371348 Degradation of endocytosed epidermal growth factor and virally ubiquitinated major histocompatibility complex class I is independent of mammalian ESCRTII. Pubmed 1.234E-7 4.077E-6 2.922E-5 8.970E-5 2 4
22 15755741 Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain. Pubmed 1.234E-7 4.077E-6 2.922E-5 8.970E-5 2 4
23 15240819 The growth-regulatory protein HCRP1/hVps37A is a subunit of mammalian ESCRT-I and mediates receptor down-regulation. Pubmed 2.056E-7 5.750E-6 4.121E-5 1.495E-4 2 5
24 17940959 Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction. Pubmed 2.056E-7 5.750E-6 4.121E-5 1.495E-4 2 5
25 22232651 Structural basis for membrane targeting by the MVB12-associated β-prism domain of the human ESCRT-I MVB12 subunit. Pubmed 2.056E-7 5.750E-6 4.121E-5 1.495E-4 2 5
26 17010938 RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment. Pubmed 2.056E-7 5.750E-6 4.121E-5 1.495E-4 2 5
27 16940516 Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages. Pubmed 3.084E-7 8.304E-6 5.952E-5 2.242E-4 2 6
28 28190767 An Interaction Landscape of Ubiquitin Signaling. Pubmed 3.274E-7 8.502E-6 6.093E-5 2.381E-4 4 468
29 20654576 Distinct functions of human MVB12A and MVB12B in the ESCRT-I dependent on their posttranslational modifications. Pubmed 4.318E-7 9.232E-6 6.616E-5 3.139E-4 2 7
30 21757351 UBAP1 is a component of an endosome-specific ESCRT-I complex that is essential for MVB sorting. Pubmed 4.318E-7 9.232E-6 6.616E-5 3.139E-4 2 7
31 23895345 Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding. Pubmed 4.318E-7 9.232E-6 6.616E-5 3.139E-4 2 7
32 11916981 Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. Pubmed 4.318E-7 9.232E-6 6.616E-5 3.139E-4 2 7
33 15509564 Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding. Pubmed 4.318E-7 9.232E-6 6.616E-5 3.139E-4 2 7
34 24284069 The molecular basis for selective assembly of the UBAP1-containing endosome-specific ESCRT-I complex. Pubmed 4.318E-7 9.232E-6 6.616E-5 3.139E-4 2 7
35 22405001 The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain. Pubmed 5.756E-7 1.196E-5 8.569E-5 4.185E-4 2 8
36 16004603 The penta-EF-hand protein ALG-2 interacts directly with the ESCRT-I component TSG101, and Ca2+-dependently co-localizes to aberrant endosomes with dominant-negative AAA ATPase SKD1/Vps4B. Pubmed 7.400E-7 1.380E-5 9.887E-5 5.380E-4 2 9
37 18005716 Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding. Pubmed 7.400E-7 1.380E-5 9.887E-5 5.380E-4 2 9
38 21762798 The role of cellular factors in promoting HIV budding. Pubmed 7.400E-7 1.380E-5 9.887E-5 5.380E-4 2 9
39 21118109 The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes. Pubmed 7.400E-7 1.380E-5 9.887E-5 5.380E-4 2 9
40 27764233 ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus. Pubmed 1.130E-6 2.055E-5 1.473E-4 8.218E-4 2 11
41 17853893 Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis. Pubmed 1.603E-6 2.842E-5 2.037E-4 1.165E-3 2 13
42 22660413 Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Pubmed 1.870E-6 3.237E-5 2.320E-4 1.359E-3 2 14
43 14505569 AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding. Pubmed 2.158E-6 3.648E-5 2.614E-4 1.569E-3 2 15
44 22004035 Essential and supporting host cell factors for HIV-1 budding. Pubmed 5.196E-6 8.585E-5 6.153E-4 3.777E-3 2 23
45 16730941 A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex. Pubmed 3.270E-5 3.112E-4 2.230E-3 2.377E-2 2 57
46 12837765 Processing of macromolecular heparin by heparanase. Pubmed 1.571E-4 3.112E-4 2.230E-3
1.142E-1
 1 1
47 19437318 Plasma heparanase as a significant marker of treatment response in children with Hodgkin lymphoma: pilot study. Pubmed 1.571E-4 3.112E-4 2.230E-3
1.142E-1
 1 1
48 15168195 HIV-1 assembly and maturation. Pubmed 1.571E-4 3.112E-4 2.230E-3
1.142E-1
 1 1
49 21117030 Down-regulation of TSG101 by small interfering RNA inhibits the proliferation of breast cancer cells through the MAPK/ERK signal pathway. Pubmed 1.571E-4 3.112E-4 2.230E-3
1.142E-1
 1 1
50 23794232 Heparanase expression correlates with poor survival in oral mucosal melanoma. Pubmed 1.571E-4 3.112E-4 2.230E-3
1.142E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 278 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:VPS36 VPS36 interactions 2.414E-10 3.750E-8 2.328E-7 6.712E-8 4 37
2 int:SNF8 SNF8 interactions 2.698E-10 3.750E-8 2.328E-7 7.501E-8 4 38
3 int:VPS28 VPS28 interactions 2.628E-9 2.435E-7 1.511E-6 7.305E-7 4 66
4 int:CHMP6 CHMP6 interactions 9.828E-9 6.830E-7 4.239E-6 2.732E-6 3 15
5 int:VPS25 VPS25 interactions 1.176E-7 6.537E-6 4.058E-5 3.269E-5 3 33
6 int:WDR12 WDR12 interactions 1.334E-6 6.179E-5 3.835E-4 3.707E-4 3 73
7 int:UBC UBC interactions 5.000E-6 1.949E-4 1.209E-3 1.390E-3 4 431
8 int:MVB12B MVB12B interactions 6.309E-6 1.949E-4 1.209E-3 1.754E-3 2 12
9 int:VPS37D VPS37D interactions 6.309E-6 1.949E-4 1.209E-3 1.754E-3 2 12
10 int:VPS37A VPS37A interactions 1.146E-5 3.187E-4 1.978E-3 3.187E-3 2 16
11 int:ALG2 ALG2 interactions 2.005E-5 4.715E-4 2.926E-3 5.573E-3 2 21
12 int:TSG101 TSG101 interactions 2.124E-5 4.715E-4 2.926E-3 5.905E-3 3 183
13 int:UBAP1 UBAP1 interactions 2.205E-5 4.715E-4 2.926E-3 6.129E-3 2 22
14 int:MVB12A MVB12A interactions 3.100E-5 6.156E-4 3.821E-3 8.618E-3 2 26
15 int:VPS37B VPS37B interactions 5.031E-5 9.324E-4 5.787E-3 1.399E-2 2 33
16 int:VPS37C VPS37C interactions 6.342E-5 1.037E-3 6.437E-3 1.763E-2 2 37
17 int:ARRDC1 ARRDC1 interactions 6.342E-5 1.037E-3 6.437E-3 1.763E-2 2 37
18 int:CHMP5 CHMP5 interactions 1.028E-4 1.587E-3 9.853E-3 2.857E-2 2 47
19 int:PPP3CB PPP3CB interactions 1.853E-4 2.711E-3 1.682E-2
5.150E-2
 2 63
20 int:HIP1R HIP1R interactions 2.159E-4 3.001E-3 1.863E-2
6.002E-2
 2 68
21 int:DPYSL2 DPYSL2 interactions 2.842E-4 3.762E-3 2.335E-2
7.901E-2
 2 78
22 int:VPS35 VPS35 interactions 3.296E-4 4.079E-3 2.532E-2
9.163E-2
 2 84
23 int:SLC25A41 SLC25A41 interactions 3.375E-4 4.079E-3 2.532E-2
9.383E-2
 2 85
24 int:VPS29 VPS29 interactions 3.783E-4 4.383E-3 2.720E-2
1.052E-1
 2 90
25 int:HDLBP HDLBP interactions 4.215E-4 4.687E-3 2.909E-2
1.172E-1
 2 95
26 int:BCR BCR interactions 4.669E-4 4.992E-3 3.099E-2
1.298E-1
 2 100
27 int:VPS26A VPS26A interactions 4.857E-4 5.001E-3 3.104E-2
1.350E-1
 2 102
28 int:CHMP4B CHMP4B interactions 5.244E-4 5.207E-3 3.232E-2
1.458E-1
 2 106
29 int:UBA52 UBA52 interactions 5.646E-4 5.413E-3 3.359E-2
1.570E-1
 2 110
30 int:ASZ1 ASZ1 interactions 6.778E-4 6.281E-3 3.898E-2
1.884E-1
 1 2
31 int:PDCD6IP PDCD6IP interactions 7.167E-4 6.427E-3 3.989E-2
1.993E-1
 2 124
32 int:NIF3L1 NIF3L1 interactions 7.516E-4 6.431E-3 3.992E-2
2.090E-1
 2 127
33 int:SPRY2 SPRY2 interactions 7.634E-4 6.431E-3 3.992E-2
2.122E-1
 2 128
34 int:USHBP1 USHBP1 interactions 7.994E-4 6.537E-3 4.057E-2
2.222E-1
 2 131
35 int:TFG TFG interactions 8.362E-4 6.642E-3 4.123E-2
2.325E-1
 2 134
36 int:GJD3 GJD3 interactions 1.016E-3 7.637E-3 4.740E-2
2.826E-1
 1 3
37 int:C22orf23 C22orf23 interactions 1.016E-3 7.637E-3 4.740E-2
2.826E-1
 1 3
38 int:DAXX DAXX interactions 1.356E-3 9.923E-3
6.159E-2
3.771E-1
 2 171
39 int:TNFAIP2 TNFAIP2 interactions 2.032E-3 1.449E-2
8.991E-2
5.649E-1
 1 6
40 int:GJB3 GJB3 interactions 2.370E-3 1.569E-2
9.738E-2
6.590E-1
 1 7
41 int:KCNN4 KCNN4 interactions 2.370E-3 1.569E-2
9.738E-2
6.590E-1
 1 7
42 int:AACS AACS interactions 2.370E-3 1.569E-2
9.738E-2
6.590E-1
 1 7
43 int:HPSE HPSE interactions 2.709E-3 1.751E-2
1.087E-1
7.530E-1
 1 8
44 int:VAX2 VAX2 interactions 3.047E-3 1.920E-2
1.192E-1
8.470E-1
 1 9
45 int:GLCCI1 GLCCI1 interactions 3.385E-3 1.920E-2
1.192E-1
9.410E-1
 1 10
46 int:CDS2 CDS2 interactions 3.385E-3 1.920E-2
1.192E-1
9.410E-1
 1 10
47 int:TNNT3 TNNT3 interactions 3.385E-3 1.920E-2
1.192E-1
9.410E-1
 1 10
48 int:PROM1 PROM1 interactions 3.385E-3 1.920E-2
1.192E-1
9.410E-1
 1 10
49 int:SCGB3A1 SCGB3A1 interactions 3.385E-3 1.920E-2
1.192E-1
9.410E-1
 1 10
50 int:SNX32 SNX32 interactions 4.061E-3 2.214E-2
1.374E-1
1.000E0
 1 12
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q21.3 4q21.3 1.903E-3 1.142E-2 2.797E-2 1.142E-2 1 11
2 13q14.3 13q14.3 7.077E-3 1.622E-2 3.973E-2 4.246E-2 1 41
3 11p15 11p15 8.109E-3 1.622E-2 3.973E-2 4.865E-2 1 47
4 2p11.2 2p11.2 1.154E-2 1.731E-2 4.242E-2
6.926E-2
 1 67
5 17q21.31 17q21.31 1.497E-2 1.796E-2 4.400E-2
8.980E-2
 1 87
6 8q24.3 8q24.3 2.179E-2 2.179E-2
5.337E-2
1.307E-1
 1 127
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 2 input genes in category / 5 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1117 ESCRT-II genenames.org 1.812E-7 7.250E-7 1.510E-6 7.250E-7 2 3
2 1116 ESCRT-I genenames.org 2.174E-6 4.347E-6 9.056E-6 8.694E-6 2 9
3 1118 Charged multivesicular body proteins|ESCRT-III genenames.org 1.922E-3 2.563E-3 5.340E-3 7.690E-3 1 7
4 482 Charged multivesicular body proteins|ESCRT-III genenames.org 3.020E-3 3.020E-3 6.291E-3 1.208E-2 1 11

13: Coexpression [Display Chart] 6 input genes in category / 449 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9824 Genes down-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4-KO versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 1.175E-5 5.276E-3 3.527E-2 5.276E-3 3 196
2 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 6.157E-4 4.894E-2
3.272E-1
2.764E-1
 2 150
3 M6103 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (6h) versus IL4 [GeneID=3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 4.894E-2
3.272E-1
4.750E-1
 2 197
4 M4917 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from LAIV influenza vaccinee pre-vaccination versus those at day 3 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 4.894E-2
3.272E-1
4.846E-1
 2 199
5 M6094 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL4 [GeneID=3565] (2h) versus untreated (2h). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.894E-2
3.272E-1
4.894E-1
 2 200
6 M5453 Genes up-regulated in comparison of mast cells versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.894E-2
3.272E-1
4.894E-1
 2 200
7 M5450 Genes up-regulated in comparison of mast cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.894E-2
3.272E-1
4.894E-1
 2 200
8 M6381 Genes up-regulated in naïve B lymphocytes versus plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.894E-2
3.272E-1
4.894E-1
 2 200
9 M8573 Genes up-regulated in T helper cells 5 days post polarization and stimulated with anti-CD3 and anti-CD28: Th1 versus Th17. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.894E-2
3.272E-1
4.894E-1
 2 200
10 M9767 Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Th1 versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 4.894E-2
3.272E-1
4.894E-1
 2 200
Show 5 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 240 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 2 input genes in category / 7 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16146 MODULE 82 Genes in the cancer module 82. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.777E-3 2.813E-2
7.294E-2
 3.344E-2 1 24
2 M1566 MODULE 568 Genes in the cancer module 568. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.449E-2 2.813E-2
7.294E-2
1.015E-1
 1 73
3 M15916 MODULE 491 Genes in the cancer module 491. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.568E-2 2.813E-2
7.294E-2
1.098E-1
 1 79
4 M9518 MODULE 243 Genes in the cancer module 243. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.608E-2 2.813E-2
7.294E-2
1.125E-1
 1 81

16: MicroRNA [Display Chart] 6 input genes in category / 185 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-376c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.183E-6 4.794E-4 2.781E-3 9.589E-4 2 43
2 hsa-miR-376b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.183E-6 4.794E-4 2.781E-3 9.589E-4 2 43
3 hsa-miR-575:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.797E-5 2.219E-3 1.287E-2 8.875E-3 2 130
4 hsa-miR-4676-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.797E-5 2.219E-3 1.287E-2 8.875E-3 2 130
5 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 6.493E-4 1.716E-2
9.953E-2
1.201E-1
 2 480
6 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 6.493E-4 1.716E-2
9.953E-2
1.201E-1
 2 480
7 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 6.493E-4 1.716E-2
9.953E-2
1.201E-1
 2 480
8 hsa-miR-8056:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.572E-3 2.843E-2
1.649E-1
4.758E-1
 1 31
9 hsa-miR-1258:Functional MTI Functional MTI miRTarbase 2.986E-3 2.843E-2
1.649E-1
5.525E-1
 1 36
10 hsa-miR-3691-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.897E-3 2.843E-2
1.649E-1
7.210E-1
 1 47
11 hsa-miR-7153-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.146E-3 2.843E-2
1.649E-1
7.670E-1
 1 50
12 hsa-miR-3617-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.311E-3 2.843E-2
1.649E-1
7.976E-1
 1 52
13 hsa-miR-3912-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.843E-2
1.649E-1
8.129E-1
 1 53
14 hsa-miR-4771:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.725E-3 2.843E-2
1.649E-1
8.741E-1
 1 57
15 hsa-miR-1261:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 2.843E-2
1.649E-1
8.894E-1
 1 58
16 hsa-miR-34c-3p:Functional MTI Functional MTI miRTarbase 4.808E-3 2.843E-2
1.649E-1
8.894E-1
 1 58
17 hsa-miR-4536-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 2.843E-2
1.649E-1
8.894E-1
 1 58
18 hsa-miR-6849-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 2.843E-2
1.649E-1
9.353E-1
 1 61
19 hsa-miR-3681-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 2.843E-2
1.649E-1
9.353E-1
 1 61
20 hsa-miR-3189-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.056E-3 2.843E-2
1.649E-1
9.353E-1
 1 61
21 hsa-miR-4752:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.139E-3 2.843E-2
1.649E-1
9.506E-1
 1 62
22 hsa-miR-3679-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.221E-3 2.843E-2
1.649E-1
9.659E-1
 1 63
23 hsa-miR-6740-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.304E-3 2.843E-2
1.649E-1
9.812E-1
 1 64
24 hsa-miR-4758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 2.843E-2
1.649E-1
9.965E-1
 1 65
25 hsa-miR-6744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.635E-3 2.843E-2
1.649E-1
1.000E0
 1 68
26 hsa-miR-219a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.843E-2
1.649E-1
1.000E0
 1 69
27 hsa-miR-1273h-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.843E-2
1.649E-1
1.000E0
 1 69
28 hsa-miR-6882-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.843E-2
1.649E-1
1.000E0
 1 69
29 hsa-miR-1185-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 2.843E-2
1.649E-1
1.000E0
 1 70
30 hsa-miR-5699-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 2.843E-2
1.649E-1
1.000E0
 1 70
31 hsa-miR-6748-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 2.843E-2
1.649E-1
1.000E0
 1 73
32 hsa-miR-571:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 2.843E-2
1.649E-1
1.000E0
 1 75
33 hsa-miR-3177-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 2.843E-2
1.649E-1
1.000E0
 1 75
34 hsa-miR-1201:PITA hsa-miR-1201:PITA TOP PITA 6.378E-3 2.843E-2
1.649E-1
1.000E0
 1 77
35 hsa-miR-888-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 2.843E-2
1.649E-1
1.000E0
 1 77
36 hsa-miR-6760-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.626E-3 2.843E-2
1.649E-1
1.000E0
 1 80
37 hsa-miR-3166:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 2.843E-2
1.649E-1
1.000E0
 1 84
38 hsa-miR-133b:Functional MTI Functional MTI miRTarbase 6.957E-3 2.843E-2
1.649E-1
1.000E0
 1 84
39 hsa-miR-3182:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 2.843E-2
1.649E-1
1.000E0
 1 84
40 hsa-miR-1199-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.039E-3 2.843E-2
1.649E-1
1.000E0
 1 85
41 hsa-miR-6751-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.204E-3 2.843E-2
1.649E-1
1.000E0
 1 87
42 hsa-miR-644a:Functional MTI Functional MTI miRTarbase 7.700E-3 2.843E-2
1.649E-1
1.000E0
 1 93
43 hsa-miR-5587-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.700E-3 2.843E-2
1.649E-1
1.000E0
 1 93
44 hsa-miR-432-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.782E-3 2.843E-2
1.649E-1
1.000E0
 1 94
45 hsa-miR-299-3p:TargetScan hsa-miR-299-3p TargetScan 7.782E-3 2.843E-2
1.649E-1
1.000E0
 1 94
46 hsa-miR-3911:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.865E-3 2.843E-2
1.649E-1
1.000E0
 1 95
47 hsa-miR-1289:PITA hsa-miR-1289:PITA TOP PITA 8.112E-3 2.843E-2
1.649E-1
1.000E0
 1 98
48 ACTGCAG,MIR-17-3P:MSigDB ACTGCAG,MIR-17-3P:MSigDB MSigDB 8.277E-3 2.843E-2
1.649E-1
1.000E0
 1 100
49 hsa-miR-4303:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.277E-3 2.843E-2
1.649E-1
1.000E0
 1 100
50 hsa-miR-7850-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.277E-3 2.843E-2
1.649E-1
1.000E0
 1 100
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 581 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000173651 ML-236A Stitch 3.850E-11 2.237E-8 1.553E-7 2.237E-8 5 134
2 CID005311039 CID5311039 Stitch 6.571E-8 1.909E-5 1.325E-4 3.818E-5 3 35
3 CID000001135 thymine Stitch 5.209E-7 1.009E-4 7.004E-4 3.027E-4 4 315
4 CID000003899 leflunomide Stitch 9.867E-7 1.433E-4 9.951E-4 5.733E-4 3 85
5 CID000000597 cytosine Stitch 1.994E-6 2.140E-4 1.486E-3 1.159E-3 4 441
6 CID000010542 D-raffinose Stitch 2.210E-6 2.140E-4 1.486E-3 1.284E-3 3 111
7 CID000002204 AC1L1D5O Stitch 5.695E-6 4.727E-4 3.282E-3 3.309E-3 3 152
8 CID000001174 uracil Stitch 3.147E-5 2.286E-3 1.587E-2 1.828E-2 3 269
9 CID000028112 lithium aluminum hydride Stitch 5.281E-5 3.409E-3 2.367E-2 3.068E-2 3 320
10 CID004631409 AC1NDTNH Stitch 6.492E-5 3.700E-3 2.569E-2 3.772E-2 3 343
11 CID000000983 polyphosphate Stitch 7.005E-5 3.700E-3 2.569E-2 4.070E-2 2 50
12 CID000053503 p-boronophenylalanine Stitch 1.224E-4 5.928E-3 4.115E-2
7.113E-2
 2 66
13 CID000097370 benzoylphenylalanine Stitch 1.418E-4 6.335E-3 4.398E-2
8.236E-2
 2 71
14 ctd:D000450 Aldosterone CTD 1.756E-4 7.287E-3
5.059E-2
1.020E-1
 2 79
15 CID005460638 I O2 Stitch 2.627E-4 1.017E-2
7.064E-2
1.526E-1
 1 1
16 CID000008757 aluminum acetate Stitch 5.253E-4 1.526E-2
1.059E-1
3.052E-1
 1 2
17 ctd:C034635 fludrocortisone acetate CTD 5.253E-4 1.526E-2
1.059E-1
3.052E-1
 1 2
18 CID000451869 NF 127 Stitch 5.253E-4 1.526E-2
1.059E-1
3.052E-1
 1 2
19 ctd:C070967 L 158809 CTD 5.253E-4 1.526E-2
1.059E-1
3.052E-1
 1 2
20 CID003043877 Seldomycin-5 Stitch 5.253E-4 1.526E-2
1.059E-1
3.052E-1
 1 2
21 ctd:C472349 oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine CTD 5.584E-4 1.526E-2
1.059E-1
3.244E-1
 2 141
22 CID000036383 HC Blue 2 Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
23 CID000061144 trichloroacetamide Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
24 CID000017734 HC Blue 1 Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
25 CID000127965 BHPM Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
26 CID000102731 4-methylpropranolol Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
27 CID000131302 CGS 5649B Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
28 CID000128762 hydroxyethylflurazepam Stitch 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
29 ctd:D047228 Angiotensin II Type 1 Receptor Blockers CTD 7.879E-4 1.526E-2
1.059E-1
4.578E-1
 1 3
30 CID000643964 PtdIns(3)P Stitch 8.580E-4 1.526E-2
1.059E-1
4.985E-1
 2 175
31 CID006857352 AC1OAGFW Stitch 9.580E-4 1.526E-2
1.059E-1
5.566E-1
 2 185
32 CID000092732 laudanine Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
33 CID000160179 perlolyrine Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
34 CID011846954 NL-8 Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
35 ctd:C120158 phosphomannopentaose sulfate CTD 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
36 CID000124345 pseudoisocytidine Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
37 CID000068251 2,4-dinitrophenylsulfenyl chloride Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
38 CID000089682 mPse Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
39 CID000089421 NSC-127489 Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
40 CID000151141 temazepam glucuronide Stitch 1.050E-3 1.526E-2
1.059E-1
6.103E-1
 1 4
41 ctd:D010433 Pentylenetetrazole CTD 1.129E-3 1.600E-2
1.111E-1
6.561E-1
 2 201
42 CID003080929 3-(2,6-xylyl)-5-methylhydantoin Stitch 1.313E-3 1.623E-2
1.127E-1
7.628E-1
 1 5
43 CID000121446 1394-48-5 Stitch 1.313E-3 1.623E-2
1.127E-1
7.628E-1
 1 5
44 CID000127616 hainanensine Stitch 1.313E-3 1.623E-2
1.127E-1
7.628E-1
 1 5
45 CID000033309 cambendazole Stitch 1.313E-3 1.623E-2
1.127E-1
7.628E-1
 1 5
46 CID000149476 methylazoxymethyl-beta-D-glucosiduronic acid Stitch 1.313E-3 1.623E-2
1.127E-1
7.628E-1
 1 5
47 CID000012960 hexaethyl tetraphosphate Stitch 1.313E-3 1.623E-2
1.127E-1
7.628E-1
 1 5
48 CID002734117 tetraoctylammonium Stitch 1.575E-3 1.795E-2
1.246E-1
9.152E-1
 1 6
49 CID000120477 A-120 Stitch 1.575E-3 1.795E-2
1.246E-1
9.152E-1
 1 6
50 CID002795122 NcAg Stitch 1.575E-3 1.795E-2
1.246E-1
9.152E-1
 1 6
Show 45 more annotations

18: Disease [Display Chart] 4 input genes in category / 149 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0340256 Sepsis-associated lung injury DisGeNET BeFree 2.468E-4 1.838E-2
1.027E-1
 3.678E-2 1 1
2 C0162569 Hepatoerythropoietic Porphyria DisGeNET Curated 4.936E-4 1.838E-2
1.027E-1
7.355E-2
 1 2
3 C1704251 Breast Lymphoma DisGeNET BeFree 4.936E-4 1.838E-2
1.027E-1
7.355E-2
 1 2
4 C1262020 Diffuse alveolar damage DisGeNET BeFree 4.936E-4 1.838E-2
1.027E-1
7.355E-2
 1 2
5 C4266441 Thyroid tumor metastasis DisGeNET BeFree 7.404E-4 1.838E-2
1.027E-1
1.103E-1
 1 3
6 C0549289 Thrombosis of inferior vena cava DisGeNET BeFree 7.404E-4 1.838E-2
1.027E-1
1.103E-1
 1 3
7 C0270913 Charcot-Marie-Tooth disease, Type 1C DisGeNET Curated 9.871E-4 1.838E-2
1.027E-1
1.471E-1
 1 4
8 C4225412 Spondylo-ocular syndrome DisGeNET Curated 9.871E-4 1.838E-2
1.027E-1
1.471E-1
 1 4
9 C2919365 Macroalbuminuric diabetic nephropathy DisGeNET BeFree 1.234E-3 2.043E-2
1.141E-1
1.838E-1
 1 5
10 C0848454 Uterine carcinoma DisGeNET BeFree 1.727E-3 2.339E-2
1.306E-1
2.573E-1
 1 7
11 C0275911 Tuberculosis of intestines DisGeNET BeFree 1.727E-3 2.339E-2
1.306E-1
2.573E-1
 1 7
12 C1368683 Epithelioma DisGeNET BeFree 1.973E-3 2.450E-2
1.368E-1
2.940E-1
 2 298
13 C0205622 Microinvasive tumor DisGeNET BeFree 2.466E-3 2.485E-2
1.388E-1
3.675E-1
 1 10
14 C0349217 Depressive episode, unspecified DisGeNET Curated 2.466E-3 2.485E-2
1.388E-1
3.675E-1
 1 10
15 C0040136 Thyroid Neoplasm DisGeNET Curated 2.502E-3 2.485E-2
1.388E-1
3.728E-1
 2 336
16 C1264039 von Willebrand Disease, Type 1 DisGeNET Curated 3.205E-3 2.985E-2
1.667E-1
4.776E-1
 1 13
17 C0221028 Neonatal thrombocytopenia (disorder) DisGeNET BeFree 3.452E-3 3.025E-2
1.689E-1
5.143E-1
 1 14
18 C0403396 Steroid-sensitive nephrotic syndrome DisGeNET BeFree 3.698E-3 3.061E-2
1.709E-1
5.510E-1
 1 15
19 C3853779 Neonatal Alloimmune Thrombocytopenia DisGeNET Curated 4.190E-3 3.164E-2
1.767E-1
6.243E-1
 1 17
20 C0020479 Hyperlipoproteinemia Type III DisGeNET Curated 4.436E-3 3.164E-2
1.767E-1
6.610E-1
 1 18
21 C0015306 Hereditary Multiple Exostoses DisGeNET Curated 5.174E-3 3.164E-2
1.767E-1
7.709E-1
 1 21
22 C0019156 Hepatic Veno-Occlusive Disease DisGeNET Curated 5.420E-3 3.164E-2
1.767E-1
8.076E-1
 1 22
23 C0027720 Nephrosis DisGeNET Curated 5.666E-3 3.164E-2
1.767E-1
8.442E-1
 1 23
24 OMIN:114480 BREAST CANCER OMIM 5.911E-3 3.164E-2
1.767E-1
8.808E-1
 1 24
25 cv:C0346153 Familial cancer of breast Clinical Variations 5.911E-3 3.164E-2
1.767E-1
8.808E-1
 1 24
26 C0010072 Coronary Thrombosis DisGeNET Curated 5.911E-3 3.164E-2
1.767E-1
8.808E-1
 1 24
27 C0206706 Verrucous carcinoma DisGeNET BeFree 6.157E-3 3.164E-2
1.767E-1
9.174E-1
 1 25
28 C0267375 Chronic colitis DisGeNET BeFree 6.157E-3 3.164E-2
1.767E-1
9.174E-1
 1 25
29 C1442903 Exostoses DisGeNET Curated 6.157E-3 3.164E-2
1.767E-1
9.174E-1
 1 25
30 C0085293 Hepatitis E DisGeNET BeFree 6.649E-3 3.302E-2
1.844E-1
9.906E-1
 1 27
31 C0346976 Secondary malignant neoplasm of pancreas DisGeNET BeFree 8.122E-3 3.904E-2
2.180E-1
1.000E0
 1 33
32 C0015302 External exotoses DisGeNET BeFree 9.103E-3 4.072E-2
2.274E-1
1.000E0
 1 37
33 C0221228 Comedone DisGeNET BeFree 9.103E-3 4.072E-2
2.274E-1
1.000E0
 1 37
34 C0085077 Sweet Syndrome DisGeNET BeFree 9.348E-3 4.072E-2
2.274E-1
1.000E0
 1 38
35 C0040021 Thromboangiitis Obliterans DisGeNET BeFree 9.593E-3 4.072E-2
2.274E-1
1.000E0
 1 39
36 C0004997 Benign Ovarian Neoplasm DisGeNET BeFree 9.838E-3 4.072E-2
2.274E-1
1.000E0
 1 40
37 C0018671 Head and Neck Neoplasms DisGeNET Curated 1.131E-2 4.212E-2
2.352E-1
1.000E0
 1 46
38 C0040015 Thrombasthenia DisGeNET Curated 1.131E-2 4.212E-2
2.352E-1
1.000E0
 1 46
39 C0002448 Ameloblastoma DisGeNET Curated 1.131E-2 4.212E-2
2.352E-1
1.000E0
 1 46
40 C0034494 Rabies (disorder) DisGeNET BeFree 1.131E-2 4.212E-2
2.352E-1
1.000E0
 1 46
41 C0086981 Sicca Syndrome DisGeNET BeFree 1.180E-2 4.287E-2
2.394E-1
1.000E0
 1 48
42 C1257930 Mammary Carcinoma, Human DisGeNET BeFree 1.253E-2 4.445E-2
2.483E-1
1.000E0
 1 51
43 C0343641 Human papilloma virus infection DisGeNET BeFree 1.302E-2 4.511E-2
2.519E-1
1.000E0
 1 53
44 C0017665 Membranous glomerulonephritis DisGeNET Curated 1.473E-2 4.929E-2
2.753E-1
1.000E0
 1 60
45 C0598894 Monocytic leukemia DisGeNET BeFree 1.522E-2 4.929E-2
2.753E-1
1.000E0
 1 62
46 C0015674 Chronic Fatigue Syndrome DisGeNET BeFree 1.522E-2 4.929E-2
2.753E-1
1.000E0
 1 62
47 C0154830 Proliferative diabetic retinopathy DisGeNET BeFree 1.571E-2 4.979E-2
2.781E-1
1.000E0
 1 64
Show 42 more annotations