Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc463_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 33 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0042043 neurexin family protein binding 6.022E-6 1.987E-4 8.126E-4 1.987E-4 2 15
2 GO:0030165 PDZ domain binding 3.655E-4 6.031E-3 2.466E-2 1.206E-2 2 114
3 GO:0050839 cell adhesion molecule binding 1.209E-3 9.245E-3 3.780E-2 3.991E-2 2 208
4 GO:0097109 neuroligin family protein binding 1.339E-3 9.245E-3 3.780E-2 4.419E-2 1 5
5 GO:0008022 protein C-terminus binding 1.401E-3 9.245E-3 3.780E-2 4.622E-2 2 224
6 GO:0033130 acetylcholine receptor binding 2.677E-3 1.472E-2
6.020E-2
8.833E-2
 1 10
7 GO:0004385 guanylate kinase activity 3.746E-3 1.766E-2
7.221E-2
1.236E-1
 1 14
8 GO:0042809 vitamin D receptor binding 4.547E-3 1.876E-2
7.669E-2
1.501E-1
 1 17
9 GO:0046966 thyroid hormone receptor binding 8.279E-3 3.036E-2
1.241E-1
2.732E-1
 1 31
10 GO:0005246 calcium channel regulator activity 1.014E-2 3.347E-2
1.368E-1
3.347E-1
 1 38
11 GO:0016776 phosphotransferase activity, phosphate group as acceptor 1.174E-2 3.521E-2
1.439E-1
3.873E-1
 1 44
12 GO:0030374 nuclear receptor transcription coactivator activity 1.439E-2 3.578E-2
1.463E-1
4.748E-1
 1 54
13 GO:0097110 scaffold protein binding 1.465E-2 3.578E-2
1.463E-1
4.835E-1
 1 55
14 GO:0019205 nucleobase-containing compound kinase activity 1.518E-2 3.578E-2
1.463E-1
5.010E-1
 1 57
15 GO:0048306 calcium-dependent protein binding 1.862E-2 3.894E-2
1.592E-1
6.144E-1
 1 70
16 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 1.888E-2 3.894E-2
1.592E-1
6.231E-1
 1 71
17 GO:0008013 beta-catenin binding 2.362E-2 4.524E-2
1.850E-1
7.795E-1
 1 89
18 GO:0001158 enhancer sequence-specific DNA binding 2.467E-2 4.524E-2
1.850E-1
8.142E-1
 1 93
19 GO:0003697 single-stranded DNA binding 2.756E-2 4.634E-2
1.895E-1
9.095E-1
 1 104
20 GO:0035326 enhancer binding 2.808E-2 4.634E-2
1.895E-1
9.268E-1
 1 106
21 GO:0001085 RNA polymerase II transcription factor binding 3.122E-2 4.906E-2
2.006E-1
1.000E0
 1 118
Show 16 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 386 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0097114 NMDA glutamate receptor clustering 8.647E-7 1.602E-4 1.047E-3 3.338E-4 2 6
2 GO:0023041 neuronal signal transduction 1.210E-6 1.602E-4 1.047E-3 4.672E-4 2 7
3 GO:0097104 postsynaptic membrane assembly 1.614E-6 1.602E-4 1.047E-3 6.229E-4 2 8
4 GO:0097105 presynaptic membrane assembly 2.075E-6 1.602E-4 1.047E-3 8.008E-4 2 9
5 GO:0097091 synaptic vesicle clustering 2.075E-6 1.602E-4 1.047E-3 8.008E-4 2 9
6 GO:0097119 postsynaptic density protein 95 clustering 2.593E-6 1.668E-4 1.090E-3 1.001E-3 2 10
7 GO:0072578 neurotransmitter-gated ion channel clustering 3.169E-6 1.747E-4 1.142E-3 1.223E-3 2 11
8 GO:0097120 receptor localization to synapse 3.802E-6 1.835E-4 1.199E-3 1.468E-3 2 12
9 GO:0097090 presynaptic membrane organization 6.047E-6 2.052E-4 1.341E-3 2.334E-3 2 15
10 GO:0007269 neurotransmitter secretion 6.499E-6 2.052E-4 1.341E-3 2.509E-3 3 163
11 GO:0099643 signal release from synapse 6.499E-6 2.052E-4 1.341E-3 2.509E-3 3 163
12 GO:0007158 neuron cell-cell adhesion 6.910E-6 2.052E-4 1.341E-3 2.667E-3 2 16
13 GO:2000310 regulation of NMDA receptor activity 6.910E-6 2.052E-4 1.341E-3 2.667E-3 2 16
14 GO:0099531 presynaptic process involved in chemical synaptic transmission 7.772E-6 2.143E-4 1.400E-3 3.000E-3 3 173
15 GO:2000311 regulation of AMPA receptor activity 1.209E-5 3.110E-4 2.032E-3 4.665E-3 2 21
16 GO:0006836 neurotransmitter transport 1.430E-5 3.340E-4 2.183E-3 5.521E-3 3 212
17 GO:0001505 regulation of neurotransmitter levels 1.471E-5 3.340E-4 2.183E-3 5.678E-3 3 214
18 GO:0051968 positive regulation of synaptic transmission, glutamatergic 1.588E-5 3.405E-4 2.225E-3 6.129E-3 2 24
19 GO:2000463 positive regulation of excitatory postsynaptic potential 1.869E-5 3.608E-4 2.358E-3 7.216E-3 2 26
20 GO:0071709 membrane assembly 1.869E-5 3.608E-4 2.358E-3 7.216E-3 2 26
21 GO:0035418 protein localization to synapse 2.174E-5 3.996E-4 2.611E-3 8.391E-3 2 28
22 GO:1900449 regulation of glutamate receptor signaling pathway 2.851E-5 4.785E-4 3.127E-3 1.101E-2 2 32
23 GO:0044091 membrane biogenesis 2.851E-5 4.785E-4 3.127E-3 1.101E-2 2 32
24 GO:0099601 regulation of neurotransmitter receptor activity 3.224E-5 4.978E-4 3.253E-3 1.245E-2 2 34
25 GO:0001941 postsynaptic membrane organization 3.224E-5 4.978E-4 3.253E-3 1.245E-2 2 34
26 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 3.419E-5 5.076E-4 3.317E-3 1.320E-2 2 35
27 GO:0098815 modulation of excitatory postsynaptic potential 3.620E-5 5.175E-4 3.382E-3 1.397E-2 2 36
28 GO:0051290 protein heterotetramerization 4.944E-5 6.816E-4 4.454E-3 1.908E-2 2 42
29 GO:0051489 regulation of filopodium assembly 5.941E-5 7.907E-4 5.167E-3 2.293E-2 2 46
30 GO:0043113 receptor clustering 7.904E-5 9.841E-4 6.431E-3 3.051E-2 2 53
31 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 7.904E-5 9.841E-4 6.431E-3 3.051E-2 2 53
32 GO:0051966 regulation of synaptic transmission, glutamatergic 9.807E-5 1.183E-3 7.730E-3 3.786E-2 2 59
33 GO:0046847 filopodium assembly 1.049E-4 1.227E-3 8.015E-3 4.048E-2 2 61
34 GO:0060079 excitatory postsynaptic potential 1.266E-4 1.438E-3 9.393E-3 4.888E-2 2 67
35 GO:0051965 positive regulation of synapse assembly 1.343E-4 1.481E-3 9.680E-3
5.185E-2
 2 69
36 GO:0034765 regulation of ion transmembrane transport 1.397E-4 1.498E-3 9.786E-3
5.392E-2
 3 455
37 GO:0034762 regulation of transmembrane transport 1.567E-4 1.613E-3 1.054E-2
6.050E-2
 3 473
38 GO:0007215 glutamate receptor signaling pathway 1.588E-4 1.613E-3 1.054E-2
6.129E-2
 2 75
39 GO:0023061 signal release 1.826E-4 1.807E-3 1.181E-2
7.048E-2
 3 498
40 GO:0050795 regulation of behavior 1.899E-4 1.832E-3 1.197E-2
7.330E-2
 2 82
41 GO:0035249 synaptic transmission, glutamatergic 1.946E-4 1.832E-3 1.197E-2
7.510E-2
 2 83
42 GO:0051963 regulation of synapse assembly 2.187E-4 2.010E-3 1.314E-2
8.443E-2
 2 88
43 GO:0048789 cytoskeletal matrix organization at active zone 2.685E-4 2.303E-3 1.505E-2
1.036E-1
 1 1
44 GO:0097115 neurexin clustering involved in presynaptic membrane assembly 2.685E-4 2.303E-3 1.505E-2
1.036E-1
 1 1
45 GO:0090126 protein-containing complex assembly involved in synapse maturation 2.685E-4 2.303E-3 1.505E-2
1.036E-1
 1 1
46 GO:0060078 regulation of postsynaptic membrane potential 2.825E-4 2.370E-3 1.549E-2
1.090E-1
 2 100
47 GO:0099565 chemical synaptic transmission, postsynaptic 3.294E-4 2.706E-3 1.768E-2
1.272E-1
 2 108
48 GO:1905114 cell surface receptor signaling pathway involved in cell-cell signaling 3.735E-4 3.003E-3 1.962E-2
1.442E-1
 2 115
49 GO:0099504 synaptic vesicle cycle 4.134E-4 3.256E-3 2.128E-2
1.596E-1
 2 121
50 GO:0050807 regulation of synapse organization 4.481E-4 3.460E-3 2.261E-2
1.730E-1
 2 126
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 48 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0097060 synaptic membrane 3.696E-5 1.326E-3 5.914E-3 1.774E-3 3 298
2 GO:0098793 presynapse 5.526E-5 1.326E-3 5.914E-3 2.653E-3 3 341
3 GO:0042734 presynaptic membrane 1.557E-4 2.491E-3 1.111E-2 7.473E-3 2 76
4 GO:0017146 NMDA selective glutamate receptor complex 3.144E-3 3.143E-2
1.401E-1
1.509E-1
 1 12
5 GO:0005652 nuclear lamina 3.406E-3 3.143E-2
1.401E-1
1.635E-1
 1 13
6 GO:0032433 filopodium tip 3.929E-3 3.143E-2
1.401E-1
1.886E-1
 1 15
Show 1 more annotation

4: Human Phenotype [Display Chart] 3 input genes in category / 331 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 200 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011270 decreased excitatory postsynaptic current amplitude 9.199E-5 1.518E-2
8.924E-2
 1.840E-2 2 32
2 MP:0011267 abnormal excitatory postsynaptic current amplitude 1.518E-4 1.518E-2
8.924E-2
 3.036E-2 2 41
3 MP:0005445 abnormal neurotransmitter secretion 6.400E-4 4.267E-2
2.508E-1
1.280E-1
 2 84

6: Domain [Display Chart] 5 input genes in category / 78 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR029824 Neurexin-1 InterPro 2.669E-4 4.625E-3 2.285E-2 2.082E-2 1 1
2 IPR030022 NLGN1 InterPro 2.669E-4 4.625E-3 2.285E-2 2.082E-2 1 1
3 SM01281 Med12 SMART 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
4 IPR021990 Mediator Med12 LCEWAV InterPro 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
5 PF12145 Med12-LCEWAV Pfam 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
6 PF12144 Med12-PQL Pfam 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
7 PF09497 Med12 Pfam 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
8 IPR019035 Mediator Med12 InterPro 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
9 IPR021989 Mediator Med12 catenin-bd InterPro 5.337E-4 4.625E-3 2.285E-2 4.163E-2 1 2
10 IPR010912 SPOC met InterPro 8.005E-4 6.244E-3 3.085E-2
6.244E-2
 1 3
11 PS50917 SPOC PROSITE 1.067E-3 7.431E-3 3.671E-2
8.324E-2
 1 4
12 IPR016194 SPOC-like C dom InterPro 1.334E-3 7.431E-3 3.671E-2
1.040E-1
 1 5
13 2.40.290.10 - Gene3D 1.334E-3 7.431E-3 3.671E-2
1.040E-1
 1 5
14 IPR000460 Nlgn InterPro 1.334E-3 7.431E-3 3.671E-2
1.040E-1
 1 5
15 PF07744 SPOC Pfam 1.600E-3 7.802E-3 3.854E-2
1.248E-1
 1 6
16 IPR012921 SPOC C InterPro 1.600E-3 7.802E-3 3.854E-2
1.248E-1
 1 6
17 PF01034 Syndecan Pfam 1.867E-3 8.090E-3 3.997E-2
1.456E-1
 1 7
18 IPR027789 Syndecan/Neurexin dom InterPro 1.867E-3 8.090E-3 3.997E-2
1.456E-1
 1 7
19 IPR014775 L27 C InterPro 2.666E-3 1.004E-2 4.958E-2
2.080E-1
 1 10
20 PF02828 L27 Pfam 2.666E-3 1.004E-2 4.958E-2
2.080E-1
 1 10
21 SM00569 L27 SMART 3.465E-3 1.004E-2 4.958E-2
2.703E-1
 1 13
22 IPR004172 L27 dom InterPro 3.465E-3 1.004E-2 4.958E-2
2.703E-1
 1 13
23 PS51022 L27 PROSITE 3.465E-3 1.004E-2 4.958E-2
2.703E-1
 1 13
24 IPR019819 Carboxylesterase B CS InterPro 3.465E-3 1.004E-2 4.958E-2
2.703E-1
 1 13
25 PF00135 COesterase Pfam 3.731E-3 1.004E-2 4.958E-2
2.910E-1
 1 14
26 SM00294 4.1m SMART 3.731E-3 1.004E-2 4.958E-2
2.910E-1
 1 14
27 IPR002018 CarbesteraseB InterPro 3.731E-3 1.004E-2 4.958E-2
2.910E-1
 1 14
28 IPR003585 Neurexin-like InterPro 3.731E-3 1.004E-2 4.958E-2
2.910E-1
 1 14
29 PS00941 CARBOXYLESTERASE B 2 PROSITE 3.731E-3 1.004E-2 4.958E-2
2.910E-1
 1 14
30 IPR020590 Guanylate kinase CS InterPro 4.263E-3 1.108E-2
5.476E-2
3.325E-1
 1 16
31 PS00856 GUANYLATE KINASE 1 PROSITE 6.124E-3 1.493E-2
7.374E-2
4.777E-1
 1 23
32 PS50052 GUANYLATE KINASE 2 PROSITE 6.124E-3 1.493E-2
7.374E-2
4.777E-1
 1 23
33 IPR008145 GK/Ca channel bsu InterPro 6.920E-3 1.499E-2
7.408E-2
5.398E-1
 1 26
34 PF00625 Guanylate kin Pfam 6.920E-3 1.499E-2
7.408E-2
5.398E-1
 1 26
35 SM00072 GuKc SMART 6.920E-3 1.499E-2
7.408E-2
5.398E-1
 1 26
36 IPR008144 Guanylate kin-like dom InterPro 6.920E-3 1.499E-2
7.408E-2
5.398E-1
 1 26
37 PS50025 LAM G DOMAIN PROSITE 1.010E-2 2.129E-2
1.052E-1
7.879E-1
 1 38
38 PF02210 Laminin G 2 Pfam 1.063E-2 2.182E-2
1.078E-1
8.292E-1
 1 40
39 SM00282 LamG SMART 1.169E-2 2.338E-2
1.155E-1
9.117E-1
 1 44
40 IPR001791 Laminin G InterPro 1.539E-2 3.000E-2
1.482E-1
1.000E0
 1 58
41 PF07653 SH3 2 Pfam 2.301E-2 4.273E-2
2.111E-1
1.000E0
 1 87
42 IPR011511 SH3 2 InterPro 2.301E-2 4.273E-2
2.111E-1
1.000E0
 1 87
43 2.60.120.200 - Gene3D 2.510E-2 4.553E-2
2.249E-1
1.000E0
 1 95
44 PS00010 ASX HYDROXYL PROSITE 2.641E-2 4.681E-2
2.313E-1
1.000E0
 1 100
45 IPR000152 EGF-type Asp/Asn hydroxyl site InterPro 2.797E-2 4.849E-2
2.395E-1
1.000E0
 1 106
Show 40 more annotations

7: Pathway [Display Chart] 5 input genes in category / 26 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1427850 Interactions of neurexins and neuroligins at synapses BioSystems: REACTOME 1.004E-6 2.493E-5 9.610E-5 2.611E-5 3 59
2 1427849 Protein-protein interactions at synapses BioSystems: REACTOME 1.918E-6 2.493E-5 9.610E-5 4.987E-5 3 73
3 1270254 Non-integrin membrane-ECM interactions BioSystems: REACTOME 1.326E-4 1.149E-3 4.430E-3 3.448E-3 2 46
4 1268763 Neuronal System BioSystems: REACTOME 2.130E-4 1.385E-3 5.337E-3 5.538E-3 3 351
5 83069 Cell adhesion molecules (CAMs) BioSystems: KEGG 1.316E-3 6.846E-3 2.639E-2 3.423E-2 2 145
6 1270244 Extracellular matrix organization BioSystems: REACTOME 5.444E-3 2.176E-2
8.386E-2
1.415E-1
 2 298
7 138046 Syndecan-1-mediated signaling events BioSystems: Pathway Interaction Database 6.810E-3 2.176E-2
8.386E-2
1.771E-1
 1 17
8 137952 Syndecan-3-mediated signaling events BioSystems: Pathway Interaction Database 6.810E-3 2.176E-2
8.386E-2
1.771E-1
 1 17
9 1270255 Syndecan interactions BioSystems: REACTOME 8.407E-3 2.176E-2
8.386E-2
2.186E-1
 1 21
10 1270243 Nephrin interactions BioSystems: REACTOME 8.806E-3 2.176E-2
8.386E-2
2.289E-1
 1 22
11 1268772 Dopamine Neurotransmitter Release Cycle BioSystems: REACTOME 9.204E-3 2.176E-2
8.386E-2
2.393E-1
 1 23
12 138031 Syndecan-2-mediated signaling events BioSystems: Pathway Interaction Database 1.319E-2 2.796E-2
1.078E-1
3.428E-1
 1 33
13 M2499 CARM1 and Regulation of the Estrogen Receptor MSigDB C2 BIOCARTA (v6.0) 1.398E-2 2.796E-2
1.078E-1
3.635E-1
 1 35
14 169347 Notch-mediated HES/HEY network BioSystems: Pathway Interaction Database 1.913E-2 3.522E-2
1.357E-1
4.974E-1
 1 48
15 1268768 Neurotransmitter Release Cycle BioSystems: REACTOME 2.032E-2 3.522E-2
1.357E-1
5.283E-1
 1 51
16 169345 Notch signaling pathway BioSystems: Pathway Interaction Database 2.308E-2 3.751E-2
1.446E-1
6.001E-1
 1 58
17 169352 Regulation of Wnt-mediated beta catenin signaling and target gene transcription BioSystems: Pathway Interaction Database 3.133E-2 4.769E-2
1.838E-1
8.146E-1
 1 79
18 P00049 Parkinson disease PantherDB 3.446E-2 4.769E-2
1.838E-1
8.960E-1
 1 87
19 1270345 Transcriptional regulation of white adipocyte differentiation BioSystems: REACTOME 3.485E-2 4.769E-2
1.838E-1
9.061E-1
 1 88
Show 14 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 618 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16186258 Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. Pubmed 3.932E-9 7.703E-7 5.396E-6 2.430E-6 3 29
2 19736351 Recurrent rearrangements in synaptic and neurodevelopmental genes and shared biologic pathways in schizophrenia, autism, and mental retardation. Pubmed 4.836E-9 7.703E-7 5.396E-6 2.989E-6 3 31
3 20869594 Neurexin-neuroligin cell adhesion complexes contribute to synaptotropic dendritogenesis via growth stabilization mechanisms in vivo. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
4 23264101 Expression of neurexin and neuroligin in the enteric nervous system and their down-regulated expression levels in Hirschsprung disease. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
5 7736595 Neuroligin 1: a splice site-specific ligand for beta-neurexins. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
6 18084303 Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
7 14522992 Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
8 12796785 Neurexin mediates the assembly of presynaptic terminals. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
9 15797875 Dissection of synapse induction by neuroligins: effect of a neuroligin mutation associated with autism. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
10 17360903 Silencing of neuroligin function by postsynaptic neurexins. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
11 19098102 Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts. Pubmed 1.371E-8 7.703E-7 5.396E-6 8.473E-6 2 2
12 19036990 Polarized targeting of neurexins to synapses is regulated by their C-terminal sequences. Pubmed 4.113E-8 2.118E-6 1.484E-5 2.542E-5 2 3
13 11036064 Mints as adaptors. Direct binding to neurexins and recruitment of munc18. Pubmed 8.226E-8 3.177E-6 2.225E-5 5.084E-5 2 4
14 8786425 CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins. Pubmed 8.226E-8 3.177E-6 2.225E-5 5.084E-5 2 4
15 26771491 Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. Pubmed 8.226E-8 3.177E-6 2.225E-5 5.084E-5 2 4
16 25399301 TGF-β1, Ghrelin, Neurexin, and Neuroligin are predictive biomarkers for postoperative prognosis of laparoscopic surgery in children with Hirschsprung disease. Pubmed 8.226E-8 3.177E-6 2.225E-5 5.084E-5 2 4
17 19816407 Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn. Pubmed 1.371E-7 4.034E-6 2.826E-5 8.472E-5 2 5
18 19926856 The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions. Pubmed 1.371E-7 4.034E-6 2.826E-5 8.472E-5 2 5
19 26078884 Neurexin-Neuroligin Synaptic Complex Regulates Schizophrenia-Related DISC1/Kal-7/Rac1 "Signalosome". Pubmed 1.371E-7 4.034E-6 2.826E-5 8.472E-5 2 5
20 15620359 Neurexins induce differentiation of GABA and glutamate postsynaptic specializations via neuroligins. Pubmed 1.371E-7 4.034E-6 2.826E-5 8.472E-5 2 5
21 12202822 SynCAM, a synaptic adhesion molecule that drives synapse assembly. Pubmed 1.371E-7 4.034E-6 2.826E-5 8.472E-5 2 5
22 8576240 Structures, alternative splicing, and neurexin binding of multiple neuroligins. Pubmed 2.056E-7 5.776E-6 4.046E-5 1.271E-4 2 6
23 26403076 Behavioral phenotypes of genetic mouse models of autism. Pubmed 4.934E-7 1.271E-5 8.900E-5 3.049E-4 2 9
24 21356198 Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Pubmed 4.934E-7 1.271E-5 8.900E-5 3.049E-4 2 9
25 27779093 MEF2C regulates cortical inhibitory and excitatory synapses and behaviors relevant to neurodevelopmental disorders. Pubmed 1.644E-6 4.064E-5 2.847E-4 1.016E-3 2 16
26 23791195 mSYD1A, a mammalian synapse-defective-1 protein, regulates synaptogenic signaling and vesicle docking. Pubmed 2.343E-6 5.568E-5 3.900E-4 1.448E-3 2 19
27 9225980 cDNAs with long CAG trinucleotide repeats from human brain. Pubmed 3.465E-6 7.931E-5 5.555E-4 2.141E-3 2 23
28 24448406 The splicing regulator PTBP2 controls a program of embryonic splicing required for neuronal maturation. Pubmed 4.451E-6 9.823E-5 6.880E-4 2.750E-3 2 26
29 24613359 Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Pubmed 1.675E-5 3.236E-4 2.267E-3 1.035E-2 2 50
30 20967226 New copy number variations in schizophrenia. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
31 26813965 A Computational Protein Phenotype Prediction Approach to Analyze the Deleterious Mutations of Human MED12 Gene. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
32 12627458 Association analysis of the HOPA12bp polymorphism in schizophrenia and manic depressive illness. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
33 20468056 Deletions of NRXN1 (neurexin-1) predispose to a wide spectrum of developmental disorders. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
34 9546224 Crystal structure of the hCASK PDZ domain reveals the structural basis of class II PDZ domain target recognition. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
35 23772147 Genome-wide association study of lung cancer in Korean non-smoking women. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
36 19822762 Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
37 24938407 MED12 overexpression is a frequent event in castration-resistant prostate cancer. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
38 28724790 MED12 regulates a transcriptional network of calcium-handling genes in the heart. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
39 28139025 A de novo splice site mutation in CASK causes FG syndrome-4 and congenital nystagmus. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
40 15777657 The C terminus of MINT forms homodimers and abrogates MINT-mediated transcriptional repression. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
41 9702738 Association of an X-chromosome dodecamer insertional variant allele with mental retardation. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
42 23225304 MED12 mutations occurring in benign and malignant mammalian smooth muscle tumors. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
43 28369444 MED12-related XLID disorders are dose-dependent of immediate early genes (IEGs) expression. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
44 23638761 Human alpha- and beta-NRXN1 isoforms rescue behavioral impairments of Caenorhabditis elegans neurexin-deficient mutants. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
45 23853109 Assembly of synapses: biomimetic assays to control neurexin/neuroligin interactions at the neuronal surface. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
46 20393883 Disturbed tooth germ development in the absence of MINT in the cultured mouse mandibular explants. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
47 21687627 Neurexin-1 and frontal lobe white matter: an overlapping intermediate phenotype for schizophrenia and autism spectrum disorders. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
48 20162629 Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
49 25839034 The interplay between synaptic activity and neuroligin function in the CNS. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
50 19880096 Copy number variation in schizophrenia in the Japanese population. Pubmed 1.309E-4 3.236E-4 2.267E-3
8.090E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 306 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NRXN1 NRXN1 interactions 9.855E-8 3.016E-5 1.901E-4 3.016E-5 3 39
2 int:NRXN2 NRXN2 interactions 2.869E-6 2.927E-4 1.845E-3 8.780E-4 2 10
3 int:NLGN1 NLGN1 interactions 2.869E-6 2.927E-4 1.845E-3 8.780E-4 2 10
4 int:NRXN3 NRXN3 interactions 5.800E-6 4.437E-4 2.796E-3 1.775E-3 2 14
5 int:RPH3A RPH3A interactions 1.471E-5 8.215E-4 5.178E-3 4.501E-3 2 22
6 int:APBA1 APBA1 interactions 1.611E-5 8.215E-4 5.178E-3 4.929E-3 2 23
7 int:SOX9 SOX9 interactions 2.069E-5 9.043E-4 5.699E-3 6.330E-3 2 26
8 int:DLG4 DLG4 interactions 3.584E-5 1.371E-3 8.640E-3 1.097E-2 3 274
9 int:LIN7C LIN7C interactions 9.079E-5 3.087E-3 1.946E-2 2.778E-2 2 54
10 int:CCNC CCNC interactions 1.710E-4 5.232E-3 3.297E-2
5.232E-2
 2 74
11 int:NLGN3 NLGN3 interactions 2.152E-4 5.986E-3 3.773E-2
6.585E-2
 2 83
12 int:CASK CASK interactions 4.275E-4 1.080E-2
6.808E-2
1.308E-1
 2 117
13 int:MED1 MED1 interactions 5.194E-4 1.080E-2
6.808E-2
1.589E-1
 2 129
14 int:FRMD7 FRMD7 interactions 5.648E-4 1.080E-2
6.808E-2
1.728E-1
 1 2
15 int:NXPH1 NXPH1 interactions 5.648E-4 1.080E-2
6.808E-2
1.728E-1
 1 2
16 int:SYT13 SYT13 interactions 5.648E-4 1.080E-2
6.808E-2
1.728E-1
 1 2
17 int:TULP1 TULP1 interactions 8.471E-4 1.476E-2
9.302E-2
2.592E-1
 1 3
18 int:DLGAP1 DLGAP1 interactions 8.682E-4 1.476E-2
9.302E-2
2.657E-1
 2 167
19 int:SYTL3 SYTL3 interactions 1.412E-3 2.088E-2
1.316E-1
4.319E-1
 1 5
20 int:TBR1 TBR1 interactions 1.412E-3 2.088E-2
1.316E-1
4.319E-1
 1 5
21 int:MED23 MED23 interactions 1.433E-3 2.088E-2
1.316E-1
4.386E-1
 2 215
22 int:SLC16A6 SLC16A6 interactions 1.976E-3 2.559E-2
1.613E-1
6.046E-1
 1 7
23 int:CNTNAP4 CNTNAP4 interactions 1.976E-3 2.559E-2
1.613E-1
6.046E-1
 1 7
24 int:SYT9 SYT9 interactions 2.258E-3 2.559E-2
1.613E-1
6.909E-1
 1 8
25 int:SYT5 SYT5 interactions 2.258E-3 2.559E-2
1.613E-1
6.909E-1
 1 8
26 int:SYTL1 SYTL1 interactions 2.258E-3 2.559E-2
1.613E-1
6.909E-1
 1 8
27 int:MYBPHL MYBPHL interactions 2.258E-3 2.559E-2
1.613E-1
6.909E-1
 1 8
28 int:CDK9 CDK9 interactions 2.606E-3 2.697E-2
1.699E-1
7.974E-1
 2 291
29 int:NXPH3 NXPH3 interactions 2.822E-3 2.697E-2
1.699E-1
8.634E-1
 1 10
30 int:CNTNAP2 CNTNAP2 interactions 2.822E-3 2.697E-2
1.699E-1
8.634E-1
 1 10
31 int:SYTL2 SYTL2 interactions 3.103E-3 2.697E-2
1.699E-1
9.496E-1
 1 11
32 int:SYT2 SYT2 interactions 3.103E-3 2.697E-2
1.699E-1
9.496E-1
 1 11
33 int:MYO16 MYO16 interactions 3.103E-3 2.697E-2
1.699E-1
9.496E-1
 1 11
34 int:IL15RA IL15RA interactions 3.385E-3 2.697E-2
1.699E-1
1.000E0
 1 12
35 int:P2RX7 P2RX7 interactions 3.385E-3 2.697E-2
1.699E-1
1.000E0
 1 12
36 int:SYT7 SYT7 interactions 3.385E-3 2.697E-2
1.699E-1
1.000E0
 1 12
37 int:GCNT3 GCNT3 interactions 3.385E-3 2.697E-2
1.699E-1
1.000E0
 1 12
38 int:PARD3B PARD3B interactions 3.667E-3 2.697E-2
1.699E-1
1.000E0
 1 13
39 int:CASKIN1 CASKIN1 interactions 3.667E-3 2.697E-2
1.699E-1
1.000E0
 1 13
40 int:ARHGEF26 ARHGEF26 interactions 3.948E-3 2.697E-2
1.699E-1
1.000E0
 1 14
41 int:WNT7B WNT7B interactions 3.948E-3 2.697E-2
1.699E-1
1.000E0
 1 14
42 int:COX20 COX20 interactions 3.948E-3 2.697E-2
1.699E-1
1.000E0
 1 14
43 int:PDZD2 PDZD2 interactions 3.948E-3 2.697E-2
1.699E-1
1.000E0
 1 14
44 int:KCNJ2 KCNJ2 interactions 4.230E-3 2.697E-2
1.699E-1
1.000E0
 1 15
45 int:IL18 IL18 interactions 4.230E-3 2.697E-2
1.699E-1
1.000E0
 1 15
46 int:GLS2 GLS2 interactions 4.230E-3 2.697E-2
1.699E-1
1.000E0
 1 15
47 int:KCNJ4 KCNJ4 interactions 4.230E-3 2.697E-2
1.699E-1
1.000E0
 1 15
48 int:WHRN WHRN interactions 4.230E-3 2.697E-2
1.699E-1
1.000E0
 1 15
49 int:LIN7B LIN7B interactions 4.511E-3 2.707E-2
1.706E-1
1.000E0
 1 16
50 int:SYT4 SYT4 interactions 4.511E-3 2.707E-2
1.706E-1
1.000E0
 1 16
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq13 Xq13 2.018E-3 5.763E-3 1.316E-2 1.009E-2 1 14
2 3q26.31 3q26.31 2.450E-3 5.763E-3 1.316E-2 1.225E-2 1 17
3 2p16.3 2p16.3 3.458E-3 5.763E-3 1.316E-2 1.729E-2 1 24
4 Xp11.4 Xp11.4 5.326E-3 6.658E-3 1.520E-2 2.663E-2 1 37
5 1p36 1p36 7.479E-3 7.479E-3 1.708E-2 3.740E-2 1 52

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 75 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 775 Myb/SANT domain containing|Trinucleotide repeat containing genenames.org 5.433E-6 2.717E-5 6.203E-5 2.717E-5 2 25
2 904 Calcium voltage-gated channel subunits|Membrane associated guanylate kinases genenames.org 4.281E-3 9.053E-3 2.067E-2 2.141E-2 1 26
3 1061 Mediator complex genenames.org 5.432E-3 9.053E-3 2.067E-2 2.716E-2 1 33
4 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 2.486E-2 3.107E-2
7.094E-2
1.243E-1
 1 152
5 725 RNA binding motif containing genenames.org 3.471E-2 3.471E-2
7.926E-2
1.736E-1
 1 213

13: Coexpression [Display Chart] 5 input genes in category / 401 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19351829-SuppTableC Human Lung Daniel09 177genes GeneSigDB 4.805E-4 4.885E-2
3.210E-1
1.927E-1
 2 162
2 M2115 Genes correlated with proneural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.732E-4 4.885E-2
3.210E-1
2.299E-1
 2 177
3 M9429 Genes up-regulated in comparison between in vivo derived natural T reg (nTreg) and converted ex-iTreg (induced T reg that lost FOXP3 [GeneID=50943] expression). MSigDB C7: Immunologic Signatures (v6.0) 7.092E-4 4.885E-2
3.210E-1
2.844E-1
 2 197
4 M5448 Genes down-regulated in comparison of mast cells versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.164E-4 4.885E-2
3.210E-1
2.873E-1
 2 198
5 M8258 Genes up-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 16h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 4.885E-2
3.210E-1
2.931E-1
 2 200
6 M7520 Genes up-regulated in untreated double positive thymocytes: wildtype versus ELK1 [GeneID=2002] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 4.885E-2
3.210E-1
2.931E-1
 2 200
7 15208663-Table2 Human Colon Kim04 26genes GeneSigDB 3.453E-3 4.895E-2
3.217E-1
1.000E0
 1 16
8 16610948-Table3 Human Leukemia Carmel06 17genes GeneSigDB 3.669E-3 4.895E-2
3.217E-1
1.000E0
 1 17
9 18302714-Figure1b Human Leukemia Hoffman08 20genes GeneSigDB 3.884E-3 4.895E-2
3.217E-1
1.000E0
 1 18
10 16239301-SuppTable3 Human Breast Harvell 20genes GeneSigDB 3.884E-3 4.895E-2
3.217E-1
1.000E0
 1 18
11 M17843 Top 20 positive significant genes associated with schwannoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.884E-3 4.895E-2
3.217E-1
1.000E0
 1 18
12 M13262 Genes responsive to estradiol [PubChem=5757] both in normal and cancer ovarian cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.100E-3 4.895E-2
3.217E-1
1.000E0
 1 19
13 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.171E-3 4.895E-2
3.217E-1
1.000E0
 2 483
14 19224407-Table1 Human StemCell Menicanin09 37genes GeneSigDB 4.315E-3 4.895E-2
3.217E-1
1.000E0
 1 20
15 17002788-Table2 Human Leukemia Hoffman06 30genes GeneSigDB 4.530E-3 4.895E-2
3.217E-1
1.000E0
 1 21
16 17150101-TableS1k Human Breast Troester06 34genes-down-sham-ZR75-1 GeneSigDB 4.530E-3 4.895E-2
3.217E-1
1.000E0
 1 21
17 19074895-SuppTable3 Human Liver Sakai08 27genes GeneSigDB 5.391E-3 4.895E-2
3.217E-1
1.000E0
 1 25
18 M14833 Up-regulated genes from the set B (Fig. 5a): specific signature shared by cells expressing either AF4-MLL or MLL-AF4 [GeneID=4299;4297] fusion proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.607E-3 4.895E-2
3.217E-1
1.000E0
 1 26
19 19936789-Table1 Human Breast Wu09 30genes GeneSigDB 5.607E-3 4.895E-2
3.217E-1
1.000E0
 1 26
20 M14614 Selected genes up-regulated in inflammatory monocytes infiltrating hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.822E-3 4.895E-2
3.217E-1
1.000E0
 1 27
21 18927283-TableS1 Human Esophagus Sabo08 29genes GeneSigDB 6.252E-3 4.895E-2
3.217E-1
1.000E0
 1 29
22 M12002 Genes up-regulated in H720 cells (lung cancer) after treatment with L663536 (MK886) [PubChem=105049], an inhibitor of leukotriene biosynthesis. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.252E-3 4.895E-2
3.217E-1
1.000E0
 1 29
23 M14591 Oxidative stress genes down-regulated in ARPE-19 cells (retinal pigmented epithelium) in response to HNE, tBH and H2O2 [PubChem=5283344;6410;784]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.541E-3 4.895E-2
3.217E-1
1.000E0
 1 35
24 18992152-table6 Human Lung Rohrbeck08 39genes CancervNormal GeneSigDB 7.756E-3 4.895E-2
3.217E-1
1.000E0
 1 36
25 19749798-TableS3 Human Lung Olaussen09 58genes GeneSigDB 8.186E-3 4.895E-2
3.217E-1
1.000E0
 1 38
26 M1551 Genes whose splicing in neocortex was most affected by knock out of NOVA2 [GeneID=4858]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.895E-2
3.217E-1
1.000E0
 1 43
27 15817677-TableS2a Human Leukemia Falt05 50genes UpRegulatedLgMutatedNon-VH3 GeneSigDB 1.012E-2 4.895E-2
3.217E-1
1.000E0
 1 47
28 16597596-TableS1-5 Human Leukemia Wilson06 50genes SigDifferentialClusterE GeneSigDB 1.012E-2 4.895E-2
3.217E-1
1.000E0
 1 47
29 16597596-TableS3-4 Human Leukemia Wilson06 50genes SigDifferentialClusterD2 GeneSigDB 1.012E-2 4.895E-2
3.217E-1
1.000E0
 1 47
30 M7202 Genes up-regulated in B-CLL (B-cell chronic lymphocytic leukemia) patients with mutated immunoglobulin variable heavy chain (VH) genes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.033E-2 4.895E-2
3.217E-1
1.000E0
 1 48
31 15817677-TableS1a Human Leukemia Falt05 50genes DownRegulatedVH3 GeneSigDB 1.055E-2 4.895E-2
3.217E-1
1.000E0
 1 49
32 M7218 Genes down-regulated in samples from B-CLL (B-cell chronic lymphocytic leukemia) with the immunoglobulin heavy chain VH3-21 gene. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.055E-2 4.895E-2
3.217E-1
1.000E0
 1 49
33 18308945-Table3 Human StemCell Huang08 60genes NSCs GeneSigDB 1.119E-2 4.895E-2
3.217E-1
1.000E0
 1 52
34 18405367-Table2a Human StemCell Tondreau08 58genes GeneSigDB 1.119E-2 4.895E-2
3.217E-1
1.000E0
 1 52
35 20036005-Table3 Human Leukemia Tavolaro10 56genes GeneSigDB 1.119E-2 4.895E-2
3.217E-1
1.000E0
 1 52
36 M10161 Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 4 h time point that were not up-regulated at the previous time point, 2 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.183E-2 4.895E-2
3.217E-1
1.000E0
 1 55
37 M15468 Cluster d4: genes progressively down-regulated in WS1 cells (fibroblast) through 12 h after irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.183E-2 4.895E-2
3.217E-1
1.000E0
 1 55
38 M6977 Genes up-regulated in primary fibroblast cell culture at 30 min time point after infection with HCMV (AD169 strain). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.183E-2 4.895E-2
3.217E-1
1.000E0
 1 55
39 19965622-TableS2a Human LymphaticEndothelialCells Norrmen09 56genes GeneSigDB 1.204E-2 4.895E-2
3.217E-1
1.000E0
 1 56
40 M6698 Up-regulated genes in metastatic vs primary solid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.418E-2 4.895E-2
3.217E-1
1.000E0
 1 66
41 19351829-SuppTableB Human Lung Daniel09 71genes GeneSigDB 1.440E-2 4.895E-2
3.217E-1
1.000E0
 1 67
42 16239301-Table1 Human Breast Harvell 87genes GeneSigDB 1.546E-2 4.895E-2
3.217E-1
1.000E0
 1 72
43 M18667 Genes down-regulated in MDA-MB-231 cells (breast cancer) after knockdown of PTHLH [GeneID=5744] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.568E-2 4.895E-2
3.217E-1
1.000E0
 1 73
44 M11718 Genes down-regulated in group D of tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609] in plasma cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.674E-2 4.895E-2
3.217E-1
1.000E0
 1 78
45 15788672-Table1 Human Prostate Gu05 120genes GeneSigDB 1.760E-2 4.895E-2
3.217E-1
1.000E0
 1 82
46 M1278 Genes down-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.760E-2 4.895E-2
3.217E-1
1.000E0
 1 82
47 18410693-TableS11 Human Leukemia Kiiveri08 100genes Hyperdiploid >50Parallel GeneSigDB 1.802E-2 4.895E-2
3.217E-1
1.000E0
 1 84
48 M17423 Genes down-regulated in serrated vs conventional colorectal carcinoma (CRC) samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.824E-2 4.895E-2
3.217E-1
1.000E0
 1 85
49 17150101-TableS1m Human Breast Troester06 120genes-down-DOX-ZR75-1 GeneSigDB 1.845E-2 4.895E-2
3.217E-1
1.000E0
 1 86
50 18410693-TableS5 Human Leukemia Kiiveri08 100genes Hyperdiploid >50Tree GeneSigDB 1.866E-2 4.895E-2
3.217E-1
1.000E0
 1 87
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 379 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAb Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iDA Subtype iDAb Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 4.786E-5 1.814E-2
1.182E-1
 1.814E-2 3 372
2 Facebase RNAseq e8.5 Paraxial Mesoderm 500 K2 FacebaseRNAseq e8.5 Paraxial Mesoderm top-relative-expression-ranked 500 k-means-cluster#2 FaceBase_RNAseq 2.185E-4 3.115E-2
2.030E-1
8.280E-2
 2 103
3 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 1000 K3 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 5.799E-4 3.115E-2
2.030E-1
2.198E-1
 2 168
4 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 7.025E-4 3.115E-2
2.030E-1
2.662E-1
 2 185
5 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 7.025E-4 3.115E-2
2.030E-1
2.662E-1
 2 185
6 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Ccnd1/Mural.Rgs5.Acta2.Ccnd1/FrontalCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Ccnd1/Mural.Rgs5.Acta2.Ccnd1/FrontalCortex BrainMap 7.253E-4 3.115E-2
2.030E-1
2.749E-1
 2 188
7 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte precursor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte precursor cell Tabula Muris Consortium 7.485E-4 3.115E-2
2.030E-1
2.837E-1
 2 191
8 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gm9946 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gm9946 BrainMap 7.563E-4 3.115E-2
2.030E-1
2.866E-1
 2 192
9 Facebase RNAseq e9.5 Olfactory Placode 1000 K2 FacebaseRNAseq e9.5 Olfactory Placode top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 9.037E-4 3.115E-2
2.030E-1
3.425E-1
 2 210
10 Facebase RNAseq e9.5 Facial Mesenchyne 1000 K4 FacebaseRNAseq e9.5 Facial Mesenchyne top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 1.018E-3 3.115E-2
2.030E-1
3.859E-1
 2 223
11 Facebase RNAseq e9.5 Maxillary Arch 1000 K4 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 1.101E-3 3.115E-2
2.030E-1
4.174E-1
 2 232
12 Facebase RNAseq ratio e9.5 MandibularArch vs MaxillaryArch 1000 K1 FacebaseRNAseq ratio e9.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 1.111E-3 3.115E-2
2.030E-1
4.209E-1
 2 233
13 Facebase RNAseq e8.5 Paraxial Mesoderm 1000 K4 FacebaseRNAseq e8.5 Paraxial Mesoderm top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 1.247E-3 3.115E-2
2.030E-1
4.725E-1
 2 247
14 Facebase RNAseq e8.5 Non-Floor Plate Neural Epithelium 1000 K2 FacebaseRNAseq e8.5 Non-Floor Plate Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 1.257E-3 3.115E-2
2.030E-1
4.763E-1
 2 248
15 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 1000 K2 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 1.267E-3 3.115E-2
2.030E-1
4.802E-1
 2 249
16 Facebase RNAseq ratio e10.5 MaxillaryArch vs Mandibular 1000 K1 FacebaseRNAseq ratio e10.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 1.328E-3 3.115E-2
2.030E-1
5.033E-1
 2 255
17 Facebase RNAseq e10.5 Mandibular Arch 1000 K3 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 1.498E-3 3.115E-2
2.030E-1
5.678E-1
 2 271
18 Facebase RNAseq e10.5 Olfactory Pit 1000 K2 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 1.587E-3 3.115E-2
2.030E-1
6.014E-1
 2 279
19 ratio SC vs MESO 500 K5 ratio StemCell vs induced-Mesoderm top-relative-expression-ranked 500 k-means-cluster#5 PCBC 1.784E-3 3.115E-2
2.030E-1
6.760E-1
 2 296
20 PCBC ratio DE from-ESC vs DE from-plasmid cfr-2X-p05 Endoderm Differentiated Cells-method NA vs Endoderm Differentiated Cells-method plasmid-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.784E-3 3.115E-2
2.030E-1
6.760E-1
 2 296
21 Facebase RNAseq e10.5 Maxillary Arch 2500 K1 FacebaseRNAseq e10.5 Maxillary Arch top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 1.905E-3 3.115E-2
2.030E-1
7.219E-1
 2 306
22 PCBC ratio DE blastocyst vs DE UCB CD34+Z cfr-2X-p05 DE blastocyst vs DE UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.954E-3 3.115E-2
2.030E-1
7.406E-1
 2 310
23 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap 1.992E-3 3.115E-2
2.030E-1
7.549E-1
 2 313
24 Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D Top 200 Genes 2.055E-3 3.115E-2
2.030E-1
7.789E-1
 2 318
25 Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte D E18.5 Top 200 Genes 2.055E-3 3.115E-2
2.030E-1
7.789E-1
 2 318
26 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iMN Subtype iMN2 Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 2.553E-3 3.684E-2
2.401E-1
9.676E-1
 2 355
27 Glioblastoma Single Cell Merged Neoplastic Subtype Neoplastic-Neoplastic.4 Top 200 Genes Glioblastoma Single Cell Merged Neoplastic Subtype Neoplastic-Neoplastic.4 Top 200 Genes 2.624E-3 3.684E-2
2.401E-1
9.947E-1
 2 360
28 Lungmap Mouse Lung E16.5 Myofibroblast Lungmap Mouse Lung E16.5 Myofibroblast Lungmap CCHMC 3.504E-3 4.743E-2
3.091E-1
1.000E0
 2 417
Show 23 more annotations

15: Computational [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 283 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-196a-5p:Functional MTI Functional MTI miRTarbase 7.261E-7 2.055E-4 1.279E-3 2.055E-4 3 303
2 hsa-miR-1274b:PITA hsa-miR-1274b:PITA TOP PITA 5.288E-5 6.084E-3 3.787E-2 1.496E-2 2 167
3 hsa-miR-552:PITA hsa-miR-552:PITA TOP PITA 6.845E-5 6.084E-3 3.787E-2 1.937E-2 2 190
4 hsa-miR-196a-5p:TargetScan hsa-miR-196a-5p TargetScan 1.454E-4 6.084E-3 3.787E-2 4.114E-2 2 277
5 hsa-miR-196b-5p:TargetScan hsa-miR-196b-5p TargetScan 1.454E-4 6.084E-3 3.787E-2 4.114E-2 2 277
6 GTGCCAA,MIR-96:MSigDB GTGCCAA,MIR-96:MSigDB MSigDB 1.517E-4 6.084E-3 3.787E-2 4.294E-2 2 283
7 ATGTACA,MIR-493:MSigDB ATGTACA,MIR-493:MSigDB MSigDB 1.637E-4 6.084E-3 3.787E-2 4.634E-2 2 294
8 hsa-miR-485-3p:TargetScan hsa-miR-485-3p TargetScan 1.939E-4 6.084E-3 3.787E-2
5.487E-2
 2 320
9 hsa-miR-539-3p:TargetScan hsa-miR-539-3p TargetScan 1.939E-4 6.084E-3 3.787E-2
5.487E-2
 2 320
10 hsa-miR-1271:PITA hsa-miR-1271:PITA TOP PITA 2.398E-4 6.084E-3 3.787E-2
6.786E-2
 2 356
11 hsa-miR-96:PITA hsa-miR-96:PITA TOP PITA 2.425E-4 6.084E-3 3.787E-2
6.863E-2
 2 358
12 hsa-miR-583:PITA hsa-miR-583:PITA TOP PITA 2.702E-4 6.084E-3 3.787E-2
7.648E-2
 2 378
13 hsa-miR-33b-5p:TargetScan hsa-miR-33b-5p TargetScan 3.010E-4 6.084E-3 3.787E-2
8.517E-2
 2 399
14 hsa-miR-33a-5p:TargetScan hsa-miR-33a-5p TargetScan 3.010E-4 6.084E-3 3.787E-2
8.517E-2
 2 399
15 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 3.624E-4 6.837E-3 4.255E-2
1.025E-1
 2 438
16 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 3.875E-4 6.853E-3 4.266E-2
1.097E-1
 2 453
17 AGCGCAG,MIR-191:MSigDB AGCGCAG,MIR-191:MSigDB MSigDB 8.303E-4 1.382E-2
8.603E-2
2.350E-1
 1 12
18 AGCGCTT,MIR-518E:MSigDB AGCGCTT,MIR-518E:MSigDB MSigDB 1.176E-3 1.550E-2
9.647E-2
3.328E-1
 1 17
19 AGCGCTT,MIR-518A:MSigDB AGCGCTT,MIR-518A:MSigDB MSigDB 1.176E-3 1.550E-2
9.647E-2
3.328E-1
 1 17
20 AGCGCTT,MIR-518F:MSigDB AGCGCTT,MIR-518F:MSigDB MSigDB 1.176E-3 1.550E-2
9.647E-2
3.328E-1
 1 17
21 ATGCACG,MIR-517B:MSigDB ATGCACG,MIR-517B:MSigDB MSigDB 1.176E-3 1.550E-2
9.647E-2
3.328E-1
 1 17
22 GCGCTTT,MIR-518C:MSigDB GCGCTTT,MIR-518C:MSigDB MSigDB 1.314E-3 1.550E-2
9.647E-2
3.720E-1
 1 19
23 GCGCTTT,MIR-518B:MSigDB GCGCTTT,MIR-518B:MSigDB MSigDB 1.314E-3 1.550E-2
9.647E-2
3.720E-1
 1 19
24 GCGCTTT,MIR-518D:MSigDB GCGCTTT,MIR-518D:MSigDB MSigDB 1.314E-3 1.550E-2
9.647E-2
3.720E-1
 1 19
25 hsa-miR-518e:PITA hsa-miR-518e:PITA TOP PITA 2.144E-3 2.333E-2
1.452E-1
6.067E-1
 1 31
26 hsa-miR-8056:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.144E-3 2.333E-2
1.452E-1
6.067E-1
 1 31
27 hsa-miR-1537-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.351E-3 2.338E-2
1.455E-1
6.654E-1
 1 34
28 hsa-miR-337-5p:PITA hsa-miR-337-5p:PITA TOP PITA 2.489E-3 2.338E-2
1.455E-1
7.045E-1
 1 36
29 hsa-miR-518c:PITA hsa-miR-518c:PITA TOP PITA 2.835E-3 2.338E-2
1.455E-1
8.022E-1
 1 41
30 hsa-miR-518d-3p:PITA hsa-miR-518d-3p:PITA TOP PITA 2.835E-3 2.338E-2
1.455E-1
8.022E-1
 1 41
31 hsa-miR-518b:PITA hsa-miR-518b:PITA TOP PITA 2.835E-3 2.338E-2
1.455E-1
8.022E-1
 1 41
32 hsa-miR-518a-3p:PITA hsa-miR-518a-3p:PITA TOP PITA 2.835E-3 2.338E-2
1.455E-1
8.022E-1
 1 41
33 hsa-miR-518f:PITA hsa-miR-518f:PITA TOP PITA 2.835E-3 2.338E-2
1.455E-1
8.022E-1
 1 41
34 hsa-miR-376c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.973E-3 2.338E-2
1.455E-1
8.413E-1
 1 43
35 hsa-miR-376b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.973E-3 2.338E-2
1.455E-1
8.413E-1
 1 43
36 hsa-miR-191-5p:TargetScan hsa-miR-191-5p TargetScan 3.042E-3 2.338E-2
1.455E-1
8.608E-1
 1 44
37 hsa-miR-3158-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.180E-3 2.338E-2
1.455E-1
8.999E-1
 1 46
38 hsa-miR-3691-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.249E-3 2.338E-2
1.455E-1
9.194E-1
 1 47
39 hsa-miR-4274:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 2.338E-2
1.455E-1
9.585E-1
 1 49
40 hsa-miR-4320:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 2.338E-2
1.455E-1
9.585E-1
 1 49
41 hsa-miR-517b:PITA hsa-miR-517b:PITA TOP PITA 3.387E-3 2.338E-2
1.455E-1
9.585E-1
 1 49
42 AGTTCTC,MIR-146A:MSigDB AGTTCTC,MIR-146A:MSigDB MSigDB 3.594E-3 2.365E-2
1.472E-1
1.000E0
 1 52
43 AGTTCTC,MIR-146B:MSigDB AGTTCTC,MIR-146B:MSigDB MSigDB 3.594E-3 2.365E-2
1.472E-1
1.000E0
 1 52
44 ACATATC,MIR-190:MSigDB ACATATC,MIR-190:MSigDB MSigDB 3.939E-3 2.530E-2
1.575E-1
1.000E0
 1 57
45 GACAGGG,MIR-339:MSigDB GACAGGG,MIR-339:MSigDB MSigDB 4.284E-3 2.530E-2
1.575E-1
1.000E0
 1 62
46 hsa-miR-4752:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.284E-3 2.530E-2
1.575E-1
1.000E0
 1 62
47 hsa-miR-1251-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.530E-2
1.575E-1
1.000E0
 1 64
48 hsa-miR-4705:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.422E-3 2.530E-2
1.575E-1
1.000E0
 1 64
49 hsa-miR-3908:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.491E-3 2.530E-2
1.575E-1
1.000E0
 1 65
50 hsa-miR-5088-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.530E-2
1.575E-1
1.000E0
 1 66
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 958 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D000726 Androgen Antagonists CTD 3.384E-7 3.242E-4 2.413E-3 3.242E-4 3 75
2 ctd:C038939 enzacamene CTD 1.787E-6 7.133E-4 5.309E-3 1.712E-3 3 130
3 ctd:C118580 octylmethoxycinnamate CTD 2.234E-6 7.133E-4 5.309E-3 2.140E-3 3 140
4 ctd:C038091 butylparaben CTD 3.215E-6 7.700E-4 5.730E-3 3.080E-3 3 158
5 CID000022311 limonene Stitch 2.545E-5 4.877E-3 3.630E-2 2.439E-2 2 37
6 CID000521238 3-octyl acetate Stitch 2.189E-4 2.150E-2
1.600E-1
2.097E-1
 1 1
7 ctd:D008044 Linuron CTD 3.130E-4 2.150E-2
1.600E-1
2.999E-1
 2 129
8 CID000079036 p-mentha-1,8-dien-3-one Stitch 4.378E-4 2.150E-2
1.600E-1
4.194E-1
 1 2
9 CID006433516 simethicone Stitch 4.378E-4 2.150E-2
1.600E-1
4.194E-1
 1 2
10 CID000010659 apiol Stitch 4.378E-4 2.150E-2
1.600E-1
4.194E-1
 1 2
11 CID000440140 planteose Stitch 4.378E-4 2.150E-2
1.600E-1
4.194E-1
 1 2
12 ctd:C035988 procymidone CTD 4.573E-4 2.150E-2
1.600E-1
4.381E-1
 2 156
13 CID000068381 perilla ketone Stitch 6.566E-4 2.150E-2
1.600E-1
6.290E-1
 1 3
14 CID000133208 menthol glucuronide Stitch 6.566E-4 2.150E-2
1.600E-1
6.290E-1
 1 3
15 CID006336690 Gaviscon Stitch 6.566E-4 2.150E-2
1.600E-1
6.290E-1
 1 3
16 CID006337812 6-selenoguanosine-5'-phosphate Stitch 6.566E-4 2.150E-2
1.600E-1
6.290E-1
 1 3
17 CID000128458 2-hydroxysebacate Stitch 6.566E-4 2.150E-2
1.600E-1
6.290E-1
 1 3
18 CID000009026 AC1L1S5M Stitch 6.566E-4 2.150E-2
1.600E-1
6.290E-1
 1 3
19 433 DN 2-propylpentanoic acid; Down 200; 1000uM; PC3; HG-U133A Broad Institute CMAP Down 7.057E-4 2.150E-2
1.600E-1
6.761E-1
 2 194
20 5812 DN Isoetharine mesylate salt [7279-75-6]; Down 200; 12uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.203E-4 2.150E-2
1.600E-1
6.900E-1
 2 196
21 4769 DN Sulfathiazole [72-14-0]; Down 200; 15.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.203E-4 2.150E-2
1.600E-1
6.900E-1
 2 196
22 2063 UP Nalbuphine hydrochloride [23277-43-2]; Up 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.203E-4 2.150E-2
1.600E-1
6.900E-1
 2 196
23 5356 DN Fluoxetine hydrochloride [59333-67-4]; Down 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.276E-4 2.150E-2
1.600E-1
6.970E-1
 2 197
24 2522 UP Napelline [5008-52-6]; Up 200; 11.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 7.276E-4 2.150E-2
1.600E-1
6.970E-1
 2 197
25 6988 UP clozapine; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.276E-4 2.150E-2
1.600E-1
6.970E-1
 2 197
26 1135 DN minocycline; Down 200; 10.5uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 7.349E-4 2.150E-2
1.600E-1
7.041E-1
 2 198
27 6332 DN Proparacaine hydrochloride [5875-06-9]; Down 200; 12uM; PC3; HT HG-U133A Broad Institute CMAP Down 7.423E-4 2.150E-2
1.600E-1
7.112E-1
 2 199
28 3689 UP PNU-0251126 [267429-19-6]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.498E-4 2.150E-2
1.600E-1
7.183E-1
 2 200
29 6475 DN Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.498E-4 2.150E-2
1.600E-1
7.183E-1
 2 200
30 ctd:D010433 Pentylenetetrazole CTD 7.572E-4 2.150E-2
1.600E-1
7.254E-1
 2 201
31 ctd:C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate CTD 8.339E-4 2.150E-2
1.600E-1
7.989E-1
 2 211
32 CID000521496 AC1LAVNU Stitch 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
33 CID000003607 hexetidine Stitch 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
34 ctd:C020763 alpha-latrotoxin CTD 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
35 CID003086011 Dynese Stitch 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
36 CID000439410 (-)-trans-Isopiperitenol Stitch 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
37 CID009863447 KB-141 Stitch 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
38 ctd:C038599 black widow spider venom CTD 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
39 CID006429305 AC1O57X2 Stitch 8.754E-4 2.150E-2
1.600E-1
8.386E-1
 1 4
40 CID000038878 2,3',5,5'-tetrachlorobiphenyl Stitch 1.094E-3 2.466E-2
1.835E-1
1.000E0
 1 5
41 CID000039971 4-hydroxy-2,2',5,5'-tetrachlorobiphenyl Stitch 1.094E-3 2.466E-2
1.835E-1
1.000E0
 1 5
42 CID000151819 diHPA Stitch 1.094E-3 2.466E-2
1.835E-1
1.000E0
 1 5
43 ctd:C029433 lead tetraacetate CTD 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
44 CID000024942 copper phosphate Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
45 CID000020414 isohexadecane Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
46 CID000129183 4'-O-(beta-D-glucopyranosyl)-D-hopantenic acid Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
47 CID000002149 GABOB Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
48 CID000128435 mV GABA Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
49 CID000002527 AC1Q5P7C Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
50 CID006478984 mycophenolic acid and ribavirin Stitch 1.313E-3 2.466E-2
1.835E-1
1.000E0
 1 6
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 320 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0220769 FG syndrome DisGeNET Curated 4.184E-6 1.040E-3 6.599E-3 1.339E-3 2 11
2 C1844806 Weight less than 3rd percentile DisGeNET Curated 1.034E-5 1.040E-3 6.599E-3 3.309E-3 2 17
3 C0041667 Underweight DisGeNET Curated 1.034E-5 1.040E-3 6.599E-3 3.309E-3 2 17
4 C0454651 Specific language impairment DisGeNET BeFree 1.300E-5 1.040E-3 6.599E-3 4.159E-3 2 19
5 C0038379 Strabismus DisGeNET Curated 5.355E-5 3.154E-3 2.002E-2 1.714E-2 3 287
6 C1858120 Generalized hypotonia DisGeNET Curated 5.913E-5 3.154E-3 2.002E-2 1.892E-2 2 40
7 C0543888 Epileptic encephalopathy DisGeNET Curated 1.207E-4 3.291E-3 2.089E-2 3.864E-2 2 57
8 C1854113 Prominent nasal bridge DisGeNET Curated 1.207E-4 3.291E-3 2.089E-2 3.864E-2 2 57
9 C4230640 Convex nasal bridge DisGeNET Curated 1.207E-4 3.291E-3 2.089E-2 3.864E-2 2 57
10 C1510586 Autism Spectrum Disorders DisGeNET Curated 1.858E-4 3.291E-3 2.089E-2
5.945E-2
 3 436
11 C0024433 Macrostomia DisGeNET Curated 1.984E-4 3.291E-3 2.089E-2
6.349E-2
 2 73
12 C2677903 Mental Retardation And Microcephaly With Pontine And Cerebellar Hypoplasia DisGeNET Curated 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
13 OMIN:309520 LUJAN-FRYNS SYNDROME OMIM 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
14 C0334477 Cellular leiomyoma DisGeNET BeFree 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
15 cv:C3280524 Schizophrenia 17 Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
16 OMIN:305450 OPITZ-KAVEGGIA SYNDROME; OKS OMIM 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
17 C0267785 Leiomyomatosis peritonealis disseminata DisGeNET BeFree 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
18 OMIN:300749 MENTAL RETARDATION AND MICROCEPHALY WITH PONTINE AND CEREBELLAR HYPOPLASIA OMIM 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
19 C4025127 Joint swelling onset late infancy DisGeNET Curated 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
20 C0343729 Anal warts DisGeNET BeFree 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
21 C0206649 Neoplasms, Fibroepithelial DisGeNET BeFree 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
22 C3698541 Ohdo syndrome, Maat-Kievit-Brunner type DisGeNET Curated 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
23 C0855056 Metastatic leiomyosarcoma DisGeNET BeFree 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
24 cv:C0220769 FG syndrome Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
25 cv:C3280479 Pitt-Hopkins-like syndrome 2 Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
26 cv:C0796022 X-linked mental retardation with marfanoid habitus syndrome Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
27 cv:C1845546 FG syndrome 4 Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
28 cv:CN169514 Ohdo syndrome, X-linked Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
29 C1845546 FG SYNDROME 4 (disorder) DisGeNET Curated 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
30 cv:C2677903 Mental retardation and microcephaly with pontine and cerebellar hypoplasia Clinical Variations 3.085E-4 3.291E-3 2.089E-2
9.873E-2
 1 1
31 C1262477 Weight decreased DisGeNET Curated 4.028E-4 4.158E-3 2.639E-2
1.289E-1
 2 104
32 C1136249 Mental Retardation, X-Linked DisGeNET Curated 4.424E-4 4.424E-3 2.808E-2
1.416E-1
 2 109
33 C0524528 Pervasive Development Disorder DisGeNET BeFree 5.009E-4 4.857E-3 3.083E-2
1.603E-1
 2 116
34 C0232466 Feeding difficulties DisGeNET Curated 6.001E-4 4.936E-3 3.133E-2
1.920E-1
 2 127
35 C1864887 Cortical Dysplasia-Focal Epilepsy Syndrome DisGeNET Curated 6.170E-4 4.936E-3 3.133E-2
1.974E-1
 1 2
36 C0796094 Blepharophimosis syndrome Ohdo type DisGeNET BeFree 6.170E-4 4.936E-3 3.133E-2
1.974E-1
 1 2
37 C0548883 Low frustration tolerance DisGeNET Curated 6.170E-4 4.936E-3 3.133E-2
1.974E-1
 1 2
38 C0262478 Wrinkled face DisGeNET Curated 6.170E-4 4.936E-3 3.133E-2
1.974E-1
 1 2
39 C1854417 Macrocephaly, postnatal DisGeNET Curated 6.170E-4 4.936E-3 3.133E-2
1.974E-1
 1 2
40 C1970777 Abnormally folded helix DisGeNET Curated 6.170E-4 4.936E-3 3.133E-2
1.974E-1
 1 2
41 C1865014 Long philtrum DisGeNET Curated 6.978E-4 5.446E-3 3.457E-2
2.233E-1
 2 137
42 C0237326 Dyschezia DisGeNET Curated 7.182E-4 5.472E-3 3.473E-2
2.298E-1
 2 139
43 C3275754 Upswept frontal hairline DisGeNET Curated 9.254E-4 6.388E-3 4.055E-2
2.961E-1
 1 3
44 C1185616 Hair whorls DisGeNET Curated 9.254E-4 6.388E-3 4.055E-2
2.961E-1
 1 3
45 C2675540 Upswept frontal hair pattern DisGeNET Curated 9.254E-4 6.388E-3 4.055E-2
2.961E-1
 1 3
46 C4021175 Microtia, first degree DisGeNET Curated 9.254E-4 6.388E-3 4.055E-2
2.961E-1
 1 3
47 C0036857 Severe mental retardation (I.Q. 20-34) DisGeNET Curated 9.383E-4 6.388E-3 4.055E-2
3.003E-1
 2 159
48 C0009806 Constipation DisGeNET Curated 1.022E-3 6.814E-3 4.325E-2
3.271E-1
 2 166
49 C0678230 Congenital Epicanthus DisGeNET Curated 1.200E-3 7.592E-3 4.819E-2
3.841E-1
 2 180
50 C0796022 Lujan Fryns syndrome DisGeNET Curated 1.234E-3 7.592E-3 4.819E-2
3.948E-1
 1 4
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