|
|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
|
1
|
11096062
|
The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
|
Pubmed
|
4.094E-18
|
4.413E-15
|
3.336E-14
|
4.413E-15
|
5
|
6
|
|
2
|
16303767
|
Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16.
|
Pubmed
|
5.582E-14
|
3.009E-11
|
2.275E-10
|
6.018E-11
|
4
|
6
|
|
3
|
11825910
|
Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
|
Pubmed
|
1.302E-13
|
3.510E-11
|
2.654E-10
|
1.404E-10
|
4
|
7
|
|
4
|
11890701
|
Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs.
|
Pubmed
|
1.302E-13
|
3.510E-11
|
2.654E-10
|
1.404E-10
|
4
|
7
|
|
5
|
20577052
|
Autophagy is essential for mouse sense of balance.
|
Pubmed
|
1.227E-12
|
2.646E-10
|
2.000E-9
|
1.323E-9
|
4
|
11
|
|
6
|
21684337
|
Alteration of autophagosomal proteins (LC3, GABARAP and GATE-16) in Lewy body disease.
|
Pubmed
|
1.777E-11
|
2.737E-9
|
2.069E-8
|
1.916E-8
|
3
|
3
|
|
7
|
19533740
|
Comparative modeling of human NSF reveals a possible binding mode of GABARAP and GATE-16.
|
Pubmed
|
1.777E-11
|
2.737E-9
|
2.069E-8
|
1.916E-8
|
3
|
3
|
|
8
|
19056683
|
The TP53INP2 protein is required for autophagy in mammalian cells.
|
Pubmed
|
1.777E-10
|
1.902E-8
|
1.438E-7
|
1.915E-7
|
3
|
5
|
|
9
|
22421968
|
TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.
|
Pubmed
|
1.777E-10
|
1.902E-8
|
1.438E-7
|
1.915E-7
|
3
|
5
|
|
10
|
23052835
|
Autophagy appears during the development of the mouse lower first molar.
|
Pubmed
|
1.777E-10
|
1.902E-8
|
1.438E-7
|
1.915E-7
|
3
|
5
|
|
11
|
20855536
|
Germline variation in apoptosis pathway genes and risk of non-Hodgkin's lymphoma.
|
Pubmed
|
1.940E-10
|
1.902E-8
|
1.438E-7
|
2.092E-7
|
4
|
35
|
|
12
|
17580304
|
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
|
Pubmed
|
3.553E-10
|
3.191E-8
|
2.413E-7
|
3.830E-7
|
3
|
6
|
|
13
|
20562859
|
Network organization of the human autophagy system.
|
Pubmed
|
9.033E-10
|
6.700E-8
|
5.065E-7
|
9.737E-7
|
6
|
433
|
|
14
|
18946037
|
FADD and caspase-8 control the outcome of autophagic signaling in proliferating T cells.
|
Pubmed
|
9.944E-10
|
6.700E-8
|
5.065E-7
|
1.072E-6
|
3
|
8
|
|
15
|
25771791
|
Autophagy receptor NDP52 regulates pathogen-containing autophagosome maturation.
|
Pubmed
|
9.944E-10
|
6.700E-8
|
5.065E-7
|
1.072E-6
|
3
|
8
|
|
16
|
22470510
|
DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
|
Pubmed
|
9.944E-10
|
6.700E-8
|
5.065E-7
|
1.072E-6
|
3
|
8
|
|
17
|
26040720
|
Regulation of endoplasmic reticulum turnover by selective autophagy.
|
Pubmed
|
1.491E-9
|
8.462E-8
|
6.397E-7
|
1.608E-6
|
3
|
9
|
|
18
|
29251248
|
The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.
|
Pubmed
|
1.491E-9
|
8.462E-8
|
6.397E-7
|
1.608E-6
|
3
|
9
|
|
19
|
21617041
|
Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth.
|
Pubmed
|
1.491E-9
|
8.462E-8
|
6.397E-7
|
1.608E-6
|
3
|
9
|
|
20
|
30217973
|
HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα.
|
Pubmed
|
2.130E-9
|
1.044E-7
|
7.892E-7
|
2.296E-6
|
3
|
10
|
|
21
|
19250911
|
A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
|
Pubmed
|
2.130E-9
|
1.044E-7
|
7.892E-7
|
2.296E-6
|
3
|
10
|
|
22
|
20010802
|
Nix is a selective autophagy receptor for mitochondrial clearance.
|
Pubmed
|
2.130E-9
|
1.044E-7
|
7.892E-7
|
2.296E-6
|
3
|
10
|
|
23
|
23043107
|
ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.
|
Pubmed
|
2.929E-9
|
1.373E-7
|
1.038E-6
|
3.157E-6
|
3
|
11
|
|
24
|
26098576
|
Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins.
|
Pubmed
|
6.458E-9
|
2.901E-7
|
2.193E-6
|
6.961E-6
|
3
|
14
|
|
25
|
26347139
|
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
|
Pubmed
|
1.718E-8
|
7.407E-7
|
5.600E-6
|
1.852E-5
|
3
|
19
|
|
26
|
25127057
|
TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
|
Pubmed
|
2.021E-8
|
8.377E-7
|
6.334E-6
|
2.178E-5
|
3
|
20
|
|
27
|
22354992
|
Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
|
Pubmed
|
5.179E-8
|
2.068E-6
|
1.563E-5
|
5.582E-5
|
3
|
27
|
|
28
|
24899049
|
Tougu Xiaotong capsule promotes chondrocyte autophagy by regulating the Atg12/LC3 conjugation systems.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
29
|
11461150
|
The subcellular distribution of GABARAP and its ability to interact with NSF suggest a role for this protein in the intracellular transport of GABA(A) receptors.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
30
|
24036476
|
Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
31
|
12507496
|
GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
32
|
30218067
|
Autophagy differentially regulates TNF receptor Fn14 by distinct mammalian Atg8 proteins.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
33
|
23671684
|
Enrichment of GABARAP relative to LC3 in the axonal initial segments of neurons.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
34
|
28320742
|
Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
35
|
21497758
|
LC3 and GATE-16 N termini mediate membrane fusion processes required for autophagosome biogenesis.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
36
|
19285958
|
The MAP1-LC3 conjugation system is involved in lipid droplet formation.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
37
|
18688877
|
Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response.
|
Pubmed
|
7.541E-8
|
2.197E-6
|
1.661E-5
|
8.129E-5
|
2
|
2
|
|
38
|
23907538
|
Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
|
Pubmed
|
1.262E-7
|
3.581E-6
|
2.707E-5
|
1.361E-4
|
3
|
36
|
|
39
|
20010805
|
The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
40
|
25498145
|
PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
41
|
27764541
|
Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
42
|
24191030
|
Structural basis of ATG3 recognition by the autophagic ubiquitin-like protein ATG12.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
43
|
24240988
|
Autophagy proteins regulate ERK phosphorylation.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
44
|
21460636
|
Dissecting the involvement of LC3B and GATE-16 in p62 recruitment into autophagosomes.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
45
|
27864321
|
Atg8 family LC3/GABARAP proteins are crucial for autophagosome-lysosome fusion but not autophagosome formation during PINK1/Parkin mitophagy and starvation.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
46
|
22033522
|
Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
47
|
22959883
|
Alteration of autophagosomal proteins in the brain of multiple system atrophy.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
48
|
27748808
|
Autophagy is involved in aldosteroneâ??induced mesangial cell proliferation.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
49
|
19635843
|
Autophagy pathway intersects with HIV-1 biosynthesis and regulates viral yields in macrophages.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|
|
50
|
11146101
|
Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
|
Pubmed
|
2.262E-7
|
4.689E-6
|
3.545E-5
|
2.438E-4
|
2
|
3
|