Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc52_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 22 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008119 thiopurine S-methyltransferase activity 9.644E-4 2.121E-2
7.827E-2
 2.122E-2 1 2
2 GO:0005412 glucose:sodium symporter activity 1.928E-3 2.121E-2
7.827E-2
 4.241E-2 1 4
3 GO:0050839 cell adhesion molecule binding 4.228E-3 3.100E-2
1.144E-1
9.301E-2
 2 208
4 GO:0005355 glucose transmembrane transporter activity 8.650E-3 3.698E-2
1.365E-1
1.903E-1
 1 18
5 GO:0015149 hexose transmembrane transporter activity 9.128E-3 3.698E-2
1.365E-1
2.008E-1
 1 19
6 GO:0015145 monosaccharide transmembrane transporter activity 1.008E-2 3.698E-2
1.365E-1
2.219E-1
 1 21
7 GO:0051119 sugar transmembrane transporter activity 1.581E-2 4.968E-2
1.834E-1
3.477E-1
 1 33
Show 2 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 149 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules 4.283E-16 6.381E-14 3.564E-13 6.381E-14 6 27
2 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 2.708E-10 2.017E-8 1.127E-7 4.035E-8 6 230
3 GO:0045216 cell-cell junction organization 3.330E-8 1.654E-6 9.236E-6 4.961E-6 5 230
4 GO:0034330 cell junction organization 5.912E-8 2.202E-6 1.230E-5 8.809E-6 5 258
5 GO:0007043 cell-cell junction assembly 7.851E-8 2.340E-6 1.307E-5 1.170E-5 4 95
6 GO:0070830 bicellular tight junction assembly 1.512E-6 3.319E-5 1.854E-4 2.253E-4 3 50
7 GO:0034329 cell junction assembly 1.559E-6 3.319E-5 1.854E-4 2.324E-4 4 200
8 GO:0043297 apical junction assembly 2.376E-6 4.426E-5 2.472E-4 3.541E-4 3 58
9 GO:0051260 protein homooligomerization 3.235E-4 5.356E-3 2.991E-2 4.821E-2 3 300
10 GO:0090138 regulation of actin cytoskeleton organization by cell-cell adhesion 4.833E-4 7.201E-3 4.021E-2
7.201E-2
 1 1
11 GO:0042552 myelination 1.463E-3 1.732E-2
9.673E-2
2.180E-1
 2 121
12 GO:0007272 ensheathment of neurons 1.511E-3 1.732E-2
9.673E-2
2.252E-1
 2 123
13 GO:0008366 axon ensheathment 1.511E-3 1.732E-2
9.673E-2
2.252E-1
 2 123
14 GO:1901552 positive regulation of endothelial cell development 1.932E-3 1.799E-2
1.005E-1
2.878E-1
 1 4
15 GO:1903142 positive regulation of establishment of endothelial barrier 1.932E-3 1.799E-2
1.005E-1
2.878E-1
 1 4
16 GO:0001951 intestinal D-glucose absorption 1.932E-3 1.799E-2
1.005E-1
2.878E-1
 1 4
17 GO:0051291 protein heterooligomerization 2.265E-3 1.985E-2
1.109E-1
3.375E-1
 2 151
18 GO:0032463 negative regulation of protein homooligomerization 3.379E-3 2.797E-2
1.562E-1
5.034E-1
 1 7
19 GO:0002318 myeloid progenitor cell differentiation 3.860E-3 3.027E-2
1.691E-1
5.752E-1
 1 8
20 GO:1901550 regulation of endothelial cell development 5.786E-3 3.812E-2
2.129E-1
8.621E-1
 1 12
21 GO:1903140 regulation of establishment of endothelial barrier 5.786E-3 3.812E-2
2.129E-1
8.621E-1
 1 12
22 GO:0032460 negative regulation of protein oligomerization 5.786E-3 3.812E-2
2.129E-1
8.621E-1
 1 12
23 GO:0002064 epithelial cell development 5.885E-3 3.812E-2
2.129E-1
8.769E-1
 2 246
24 GO:0046498 S-adenosylhomocysteine metabolic process 6.266E-3 3.890E-2
2.173E-1
9.337E-1
 1 13
25 GO:0001780 neutrophil homeostasis 7.227E-3 3.988E-2
2.227E-1
1.000E0
 1 15
26 GO:0002523 leukocyte migration involved in inflammatory response 7.227E-3 3.988E-2
2.227E-1
1.000E0
 1 15
27 GO:0045603 positive regulation of endothelial cell differentiation 7.227E-3 3.988E-2
2.227E-1
1.000E0
 1 15
28 GO:0032462 regulation of protein homooligomerization 7.708E-3 4.101E-2
2.290E-1
1.000E0
 1 16
29 GO:1904659 glucose transmembrane transport 8.667E-3 4.305E-2
2.404E-1
1.000E0
 1 18
30 GO:0046500 S-adenosylmethionine metabolic process 8.667E-3 4.305E-2
2.404E-1
1.000E0
 1 18
31 GO:0061436 establishment of skin barrier 1.011E-2 4.857E-2
2.712E-1
1.000E0
 1 21
Show 26 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 29 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005923 bicellular tight junction 1.227E-17 2.201E-16 8.719E-16 3.560E-16 8 115
2 GO:0070160 tight junction 1.518E-17 2.201E-16 8.719E-16 4.402E-16 8 118
3 GO:0043296 apical junction complex 3.587E-17 3.467E-16 1.374E-15 1.040E-15 8 131
4 GO:0005911 cell-cell junction 1.078E-15 7.812E-15 3.095E-14 3.125E-14 9 418
5 GO:0016327 apicolateral plasma membrane 6.974E-14 4.045E-13 1.602E-12 2.023E-12 5 19
6 GO:0016328 lateral plasma membrane 1.685E-6 8.145E-6 3.227E-5 4.887E-5 3 53
7 GO:0043220 Schmidt-Lanterman incisure 2.074E-5 8.594E-5 3.404E-4 6.015E-4 2 15
8 GO:0043218 compact myelin 3.375E-5 1.223E-4 4.847E-4 9.787E-4 2 19
9 GO:0016324 apical plasma membrane 4.178E-4 1.346E-3 5.333E-3 1.212E-2 3 335
10 GO:0045177 apical part of cell 8.538E-4 2.476E-3 9.809E-3 2.476E-2 3 428
11 GO:0033010 paranodal junction 2.359E-3 6.219E-3 2.464E-2
6.841E-2
 1 5
12 GO:0043209 myelin sheath 3.831E-3 9.258E-3 3.668E-2
1.111E-1
 2 202
13 GO:0033270 paranode region of axon 7.062E-3 1.575E-2
6.241E-2
2.048E-1
 1 15
14 GO:0030057 desmosome 1.221E-2 2.530E-2
1.002E-1
3.542E-1
 1 26
Show 9 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 109 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 8 input genes in category / 179 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0006316 increased urine sodium level 1.347E-6 2.411E-4 1.390E-3 2.411E-4 3 31
2 MP:0006274 abnormal urine sodium level 1.176E-5 1.053E-3 6.071E-3 2.105E-3 3 63
3 MP:0011459 increased urine chloride ion level 5.457E-5 3.256E-3 1.878E-2 9.768E-3 2 15
4 MP:0011458 abnormal urine chloride ion level 1.429E-4 5.560E-3 3.207E-2 2.559E-2 2 24
5 MP:0005619 increased urine potassium level 1.553E-4 5.560E-3 3.207E-2 2.780E-2 2 25
6 MP:0011977 abnormal sodium ion homeostasis 2.098E-4 6.259E-3 3.610E-2 3.755E-2 3 165
7 MP:0001211 wrinkled skin 3.815E-4 9.233E-3
5.325E-2
6.829E-2
 2 39
8 MP:0004820 abnormal urine potassium level 4.428E-4 9.233E-3
5.325E-2
7.926E-2
 2 42
9 MP:0010107 abnormal renal reabsorbtion 4.642E-4 9.233E-3
5.325E-2
8.310E-2
 2 43
10 MP:0001429 dehydration 2.489E-3 3.947E-2
2.276E-1
4.456E-1
 2 100
11 MP:0012007 abnormal chloride level 3.057E-3 3.947E-2
2.276E-1
5.472E-1
 2 111
12 MP:0011923 abnormal bladder urine volume 3.087E-3 3.947E-2
2.276E-1
5.526E-1
 1 4
13 MP:0011466 increased urine urea nitrogen level 3.087E-3 3.947E-2
2.276E-1
5.526E-1
 1 4
14 MP:0011447 abnormal renal glucose reabsorption 3.087E-3 3.947E-2
2.276E-1
5.526E-1
 1 4
15 MP:0011978 abnormal potassium ion homeostasis 4.231E-3 4.873E-2
2.810E-1
7.573E-1
 2 131
16 MP:0009643 abnormal urine homeostasis 4.438E-3 4.873E-2
2.810E-1
7.944E-1
 3 472
17 MP:0010109 abnormal renal sodium reabsorbtion 4.628E-3 4.873E-2
2.810E-1
8.283E-1
 1 6
Show 12 more annotations

6: Domain [Display Chart] 9 input genes in category / 37 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS01346 CLAUDIN PROSITE 1.042E-16 1.928E-15 8.100E-15 3.856E-15 6 22
2 IPR017974 Claudin CS InterPro 1.042E-16 1.928E-15 8.100E-15 3.856E-15 6 22
3 IPR006187 Claudin InterPro 5.257E-16 6.484E-15 2.724E-14 1.945E-14 6 28
4 PF00822 PMP22 Claudin Pfam 5.348E-15 4.947E-14 2.078E-13 1.979E-13 6 40
5 IPR004031 PMP22/EMP/MP20/Claudin InterPro 1.134E-14 8.391E-14 3.526E-13 4.196E-13 6 45
6 IPR003551 Claudin5 InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
7 IPR003925 Claudin6 InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
8 IPR003552 Claudin7 InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
9 IPR003548 Claudin1 InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
10 IPR003549 Claudin3 InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
11 IPR005411 Claudin2 InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
12 IPR002958 Occludin InterPro 4.804E-4 1.481E-3 6.223E-3 1.777E-2 1 1
13 PF07303 Occludin ELL Pfam 2.879E-3 7.102E-3 2.984E-2
1.065E-1
 1 6
14 IPR010844 Occludin ELL InterPro 2.879E-3 7.102E-3 2.984E-2
1.065E-1
 1 6
15 IPR031176 ELL/occludin InterPro 2.879E-3 7.102E-3 2.984E-2
1.065E-1
 1 6
16 IPR018212 Na/solute symporter CS InterPro 3.837E-3 8.874E-3 3.728E-2
1.420E-1
 1 8
17 PS00456 NA SOLUT SYMP 1 PROSITE 5.273E-3 1.013E-2 4.257E-2
1.951E-1
 1 11
18 PS00457 NA SOLUT SYMP 2 PROSITE 5.751E-3 1.013E-2 4.257E-2
2.128E-1
 1 12
19 PS50283 NA SOLUT SYMP 3 PROSITE 5.751E-3 1.013E-2 4.257E-2
2.128E-1
 1 12
20 PF00474 SSF Pfam 5.751E-3 1.013E-2 4.257E-2
2.128E-1
 1 12
21 IPR001734 Na/solute symporter InterPro 5.751E-3 1.013E-2 4.257E-2
2.128E-1
 1 12
22 PF01284 MARVEL Pfam 1.290E-2 2.062E-2
8.663E-2
4.772E-1
 1 27
23 IPR008253 Marvel InterPro 1.337E-2 2.062E-2
8.663E-2
4.948E-1
 1 28
24 PS51225 MARVEL PROSITE 1.337E-2 2.062E-2
8.663E-2
4.948E-1
 1 28
Show 19 more annotations

7: Pathway [Display Chart] 9 input genes in category / 33 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83083 Leukocyte transendothelial migration BioSystems: KEGG 3.441E-16 1.136E-14 4.643E-14 1.136E-14 8 114
2 83069 Cell adhesion molecules (CAMs) BioSystems: KEGG 2.484E-15 4.099E-14 1.676E-13 8.198E-14 8 145
3 83071 Tight junction BioSystems: KEGG 9.116E-15 9.826E-14 4.018E-13 3.008E-13 8 170
4 1270236 Tight junction interactions BioSystems: REACTOME 1.191E-14 9.826E-14 4.018E-13 3.930E-13 6 31
5 173973 Hepatitis C BioSystems: KEGG 4.299E-13 2.837E-12 1.160E-11 1.419E-11 7 131
6 1270233 Cell-cell junction organization BioSystems: REACTOME 9.880E-13 5.434E-12 2.222E-11 3.261E-11 6 62
7 1270232 Cell junction organization BioSystems: REACTOME 9.288E-12 4.378E-11 1.790E-10 3.065E-10 6 89
8 1270231 Cell-Cell communication BioSystems: REACTOME 1.137E-10 4.688E-10 1.917E-9 3.751E-9 6 134
9 83103 Pathogenic Escherichia coli infection BioSystems: KEGG 6.763E-4 2.480E-3 1.014E-2 2.232E-2 2 55
10 PW:0000561 sodium-glucose cotransporter mediated glucose transport Pathway Ontology 1.445E-3 4.770E-3 1.950E-2 4.770E-2 1 2
11 1269926 Na+-dependent glucose transporters BioSystems: REACTOME 4.330E-3 1.299E-2
5.312E-2
1.429E-1
 1 6
12 1269927 Inositol transporters BioSystems: REACTOME 5.050E-3 1.389E-2
5.679E-2
1.667E-1
 1 7
13 1270290 Apoptotic cleavage of cell adhesion proteins BioSystems: REACTOME 7.926E-3 2.012E-2
8.227E-2
2.616E-1
 1 11
14 PW:0000398 homocysteine metabolic Pathway Ontology 1.294E-2 3.050E-2
1.247E-1
4.271E-1
 1 18
15 138054 Nectin adhesion pathway BioSystems: Pathway Interaction Database 1.793E-2 3.699E-2
1.512E-1
5.918E-1
 1 25
16 PW:0000048 methionine cycle/metabolic Pathway Ontology 1.793E-2 3.699E-2
1.512E-1
5.918E-1
 1 25
Show 11 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 1244 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10601346 Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins. Pubmed 1.213E-24 1.508E-21 1.162E-20 1.508E-21 7 12
2 15366020 Expression patterns of claudin family of tight junction membrane proteins in developing mouse submandibular gland. Pubmed 5.254E-24 3.268E-21 2.518E-20 6.536E-21 7 14
3 9892664 Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Pubmed 5.457E-22 2.263E-19 1.743E-18 6.789E-19 6 8
4 17075866 Expression of claudins in murine tooth development. Pubmed 9.003E-21 2.800E-18 2.157E-17 1.120E-17 6 11
5 18480174 Biology of claudins. Pubmed 3.616E-19 8.996E-17 6.930E-16 4.498E-16 6 18
6 11283726 Multifunctional strands in tight junctions. Pubmed 1.057E-18 1.315E-16 1.013E-15 1.315E-15 6 21
7 12231346 Claudin-based barrier in simple and stratified cellular sheets. Pubmed 1.057E-18 1.315E-16 1.013E-15 1.315E-15 6 21
8 12475568 Tight junction proteins. Pubmed 1.057E-18 1.315E-16 1.013E-15 1.315E-15 6 21
9 11247307 The roles of claudin superfamily proteins in paracellular transport. Pubmed 1.057E-18 1.315E-16 1.013E-15 1.315E-15 6 21
10 10690502 Tight junctions of the blood-brain barrier. Pubmed 1.057E-18 1.315E-16 1.013E-15 1.315E-15 6 21
11 19706201 The claudins. Pubmed 1.966E-18 2.038E-16 1.570E-15 2.445E-15 6 23
12 18036336 Structure and function of claudins. Pubmed 1.966E-18 2.038E-16 1.570E-15 2.445E-15 6 23
13 22275141 Dynamic distribution of claudin proteins in pancreatic epithelia undergoing morphogenesis or neoplastic transformation. Pubmed 4.482E-18 4.289E-16 3.304E-15 5.575E-15 6 26
14 22946046 Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury. Pubmed 1.042E-17 9.258E-16 7.132E-15 1.296E-14 5 8
15 24840331 HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy. Pubmed 2.344E-17 1.944E-15 1.498E-14 2.916E-14 5 9
16 17182288 The temporal and spatial expression of Claudins in epidermal development and the accelerated program of epidermal differentiation in K14-CaSR transgenic mice. Pubmed 4.688E-17 3.430E-15 2.643E-14 5.831E-14 5 10
17 11923212 Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Pubmed 4.688E-17 3.430E-15 2.643E-14 5.831E-14 5 10
18 17103306 Transepithelial leak in Barrett's esophagus. Pubmed 1.421E-15 9.823E-14 7.568E-13 1.768E-12 4 4
19 22155109 Probiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function. Pubmed 2.161E-15 1.415E-13 1.090E-12 2.689E-12 5 19
20 20478039 Divergent expression of claudin -1, -3, -4, -5 and -7 in developing human lung. Pubmed 7.106E-15 3.844E-13 2.961E-12 8.840E-12 4 5
21 17418912 Distinct claudin expression profile in histologic subtypes of lung cancer. Pubmed 7.106E-15 3.844E-13 2.961E-12 8.840E-12 4 5
22 9824655 Tight junction proteins. Pubmed 7.106E-15 3.844E-13 2.961E-12 8.840E-12 4 5
23 18550469 Expression of occludin and claudins 1, 3, 4, and 7 in urothelial carcinoma of the upper urinary tract. Pubmed 7.106E-15 3.844E-13 2.961E-12 8.840E-12 4 5
24 19924644 Claudins in human cancer: a review. Pubmed 9.946E-14 5.155E-12 3.971E-11 1.237E-10 4 8
25 16520537 Developmental changes in the expression of tight junction protein claudins in murine metanephroi and embryonic kidneys. Pubmed 2.983E-13 1.325E-11 1.021E-10 3.711E-10 4 10
26 11585919 claudin-18, a novel downstream target gene for the T/EBP/NKX2.1 homeodomain transcription factor, encodes lung- and stomach-specific isoforms through alternative splicing. Pubmed 2.983E-13 1.325E-11 1.021E-10 3.711E-10 4 10
27 29617460 Loss of HAI-2 in mice with decreased prostasin activity leads to an early-onset intestinal failure resembling congenital tufting enteropathy. Pubmed 2.983E-13 1.325E-11 1.021E-10 3.711E-10 4 10
28 20375010 Claudin association with CD81 defines hepatitis C virus entry. Pubmed 2.983E-13 1.325E-11 1.021E-10 3.711E-10 4 10
29 22819673 EpCAM contributes to formation of functional tight junction in the intestinal epithelium by recruiting claudin proteins. Pubmed 7.030E-13 3.016E-11 2.323E-10 8.745E-10 4 12
30 18817843 Expression of Claudin-1, Claudin-3 and Claudin-5 in human blood-brain barrier mimicking cell line ECV304 is inducible by glioma-conditioned media. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
31 9786950 A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
32 25323998 The effect of claudin-5 overexpression on the interactions of claudin-1 and -2 and barrier function in retinal cells. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
33 21098027 Claudin-2 forms homodimers and is a component of a high molecular weight protein complex. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
34 28415153 Polar and charged extracellular residues conserved among barrier-forming claudins contribute to tight junction strand formation. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
35 12909588 Role of claudin interactions in airway tight junctional permeability. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
36 10562289 Manner of interaction of heterogeneous claudin species within and between tight junction strands. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
37 17283368 Tight junction proteins in gallbladder epithelium: different expression in acute acalculous and calculous cholecystitis. Pubmed 9.047E-12 3.042E-10 2.343E-9 1.125E-8 3 3
38 22178591 Pancreas-specific deletion of Prox1 affects development and disrupts homeostasis of the exocrine pancreas. Pubmed 2.489E-11 8.147E-10 6.276E-9 3.096E-8 4 27
39 10508613 Ca(2+)-independent cell-adhesion activity of claudins, a family of integral membrane proteins localized at tight junctions. Pubmed 3.618E-11 1.023E-9 7.881E-9 4.501E-8 3 4
40 19231096 Diagnostic utility of expression of claudins in non-small cell lung cancer: different expression profiles in squamous cell carcinomas and adenocarcinomas. Pubmed 3.618E-11 1.023E-9 7.881E-9 4.501E-8 3 4
41 24815833 Expression of claudins-1, -4, -5, -7 and occludin in hepatocellular carcinoma and their relation with classic clinicopathological features and patients' survival. Pubmed 3.618E-11 1.023E-9 7.881E-9 4.501E-8 3 4
42 9441748 Analysis of a human gene homologous to rat ventral prostate.1 protein. Pubmed 3.618E-11 1.023E-9 7.881E-9 4.501E-8 3 4
43 18802961 Hepatitis C virus envelope components alter localization of hepatocyte tight junction-associated proteins and promote occludin retention in the endoplasmic reticulum. Pubmed 3.618E-11 1.023E-9 7.881E-9 4.501E-8 3 4
44 20204275 Claudin expression profiles in Epstein-Barr virus-associated nasopharyngeal carcinoma. Pubmed 3.618E-11 1.023E-9 7.881E-9 4.501E-8 3 4
45 18329007 Methamphetamine alters blood brain barrier permeability via the modulation of tight junction expression: Implication for HIV-1 neuropathogenesis in the context of drug abuse. Pubmed 9.045E-11 2.344E-9 1.806E-8 1.125E-7 3 5
46 15070779 Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins. Pubmed 9.045E-11 2.344E-9 1.806E-8 1.125E-7 3 5
47 19661441 Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines. Pubmed 9.045E-11 2.344E-9 1.806E-8 1.125E-7 3 5
48 10508865 Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. Pubmed 9.045E-11 2.344E-9 1.806E-8 1.125E-7 3 5
49 18538010 HIV-1 Tat protein alter the tight junction integrity and function of retinal pigment epithelium: an in vitro study. Pubmed 5.063E-10 1.285E-8 9.903E-8 6.299E-7 3 8
50 14698084 Expression patterns of claudins, tight junction adhesion molecules, in the inner ear. Pubmed 7.594E-10 1.889E-8 1.456E-7 9.447E-7 3 9
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 97 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TJP1 TJP1 interactions 7.801E-17 7.567E-15 3.902E-14 7.567E-15 8 134
2 int:CLDN3 CLDN3 interactions 7.620E-9 3.696E-7 1.906E-6 7.392E-7 3 9
3 int:WNK4 WNK4 interactions 5.071E-8 1.640E-6 8.456E-6 4.919E-6 3 16
4 int:CLDN5 CLDN5 interactions 1.378E-6 3.341E-5 1.723E-4 1.336E-4 2 4
5 int:TJP2 TJP2 interactions 6.024E-6 1.169E-4 6.027E-4 5.843E-4 3 75
6 int:TJP3 TJP3 interactions 1.261E-5 2.038E-4 1.051E-3 1.223E-3 2 11
7 int:CLDN1 CLDN1 interactions 1.787E-5 2.476E-4 1.277E-3 1.733E-3 2 13
8 int:MPDZ MPDZ interactions 2.150E-4 2.606E-3 1.344E-2 2.085E-2 2 44
9 int:SYNE4 SYNE4 interactions 9.596E-4 9.861E-3
5.085E-2
9.308E-2
 2 93
10 int:CLDN6 CLDN6 interactions 1.017E-3 9.861E-3
5.085E-2
9.861E-2
 1 2
11 int:SLC5A1 SLC5A1 interactions 1.524E-3 1.344E-2
6.933E-2
1.479E-1
 1 3
12 int:ITGAX ITGAX interactions 2.540E-3 1.895E-2
9.772E-2
2.463E-1
 1 5
13 int:HGD HGD interactions 2.540E-3 1.895E-2
9.772E-2
2.463E-1
 1 5
14 int:EPCAM EPCAM interactions 3.047E-3 2.111E-2
1.089E-1
2.955E-1
 1 6
15 int:MFAP4 MFAP4 interactions 3.554E-3 2.298E-2
1.185E-1
3.447E-1
 1 7
16 int:CLDN7 CLDN7 interactions 4.567E-3 2.577E-2
1.329E-1
4.430E-1
 1 9
17 int:F2RL2 F2RL2 interactions 4.567E-3 2.577E-2
1.329E-1
4.430E-1
 1 9
18 int:MPZL2 MPZL2 interactions 5.074E-3 2.577E-2
1.329E-1
4.921E-1
 1 10
19 int:JAM3 JAM3 interactions 5.074E-3 2.577E-2
1.329E-1
4.921E-1
 1 10
20 int:CLDN2 CLDN2 interactions 5.580E-3 2.577E-2
1.329E-1
5.412E-1
 1 11
21 int:JAM2 JAM2 interactions 5.580E-3 2.577E-2
1.329E-1
5.412E-1
 1 11
22 int:MAN1A1 MAN1A1 interactions 6.086E-3 2.683E-2
1.384E-1
5.903E-1
 1 12
23 int:GJB1 GJB1 interactions 7.097E-3 2.993E-2
1.543E-1
6.884E-1
 1 14
24 int:SYT12 SYT12 interactions 9.116E-3 3.684E-2
1.900E-1
8.842E-1
 1 18
25 int:CLEC7A CLEC7A interactions 1.113E-2 4.319E-2
2.227E-1
1.000E0
 1 22
26 int:ITGAM ITGAM interactions 1.163E-2 4.341E-2
2.239E-1
1.000E0
 1 23
27 int:C4A C4A interactions 1.264E-2 4.541E-2
2.342E-1
1.000E0
 1 25
28 int:PREB PREB interactions 1.365E-2 4.727E-2
2.438E-1
1.000E0
 1 27
29 int:MMP14 MMP14 interactions 1.415E-2 4.732E-2
2.441E-1
1.000E0
 1 28
30 int:AQP2 AQP2 interactions 1.465E-2 4.737E-2
2.443E-1
1.000E0
 1 29
31 int:LNX1 LNX1 interactions 1.550E-2 4.850E-2
2.501E-1
1.000E0
 2 387
Show 26 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Xq22.3-q23 Xq22.3-q23 6.923E-4 3.691E-3 1.003E-2 5.538E-3 1 3
2 3q28-q29 3q28-q29 9.229E-4 3.691E-3 1.003E-2 7.384E-3 1 4
3 5q13.1 5q13.1 1.384E-3 3.691E-3 1.003E-2 1.107E-2 1 6
4 11q25 11q25 7.133E-3 1.325E-2 3.601E-2
5.707E-2
 1 31
5 22q12.3 22q12.3 8.280E-3 1.325E-2 3.601E-2
6.624E-2
 1 36
6 7q11.23 7q11.23 2.353E-2 3.137E-2
8.527E-2
1.882E-1
 1 103
7 22q11.21 22q11.21 2.782E-2 3.179E-2
8.640E-2
2.225E-1
 1 122
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 70 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 9 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 488 Claudins genenames.org 1.681E-16 8.403E-16 1.919E-15 8.403E-16 6 23

13: Coexpression [Display Chart] 9 input genes in category / 746 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5915 Genes encoding components of apical junction complex. MSigDB H: Hallmark Gene Sets (v6.0) 6.599E-7 4.923E-4 3.541E-3 4.923E-4 4 200
2 20521089-SuppTable1b Human Breast Blick10 11genes EMT down GeneSigDB 6.043E-6 1.681E-3 1.209E-2 4.508E-3 2 10
3 M18160 Genes down-regulated by ESRRA [GeneID=2101] only. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.479E-6 1.681E-3 1.209E-2 5.579E-3 3 105
4 19168792-TableS2 Human Leukemia Figueroa09 567genes GeneSigDB 1.243E-5 1.681E-3 1.209E-2 9.274E-3 4 419
5 M2574 Genes consistently down-regulated in mammary stem cells both in mouse and human species. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.352E-5 1.681E-3 1.209E-2 1.008E-2 4 428
6 M18855 Up-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.352E-5 1.681E-3 1.209E-2 1.008E-2 4 428
7 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.857E-5 1.980E-3 1.424E-2 1.386E-2 4 464
8 15994935-Table3a Human Kidney Yang05 50genes UpExpressedClass1 GeneSigDB 4.697E-5 4.192E-3 3.015E-2 3.504E-2 2 27
9 19584277-Table2 Human Breast Marella09 30genes GeneSigDB 5.058E-5 4.192E-3 3.015E-2 3.773E-2 2 28
10 M9893 Genes whose expression increases with age in normal kidney, excluding those with higher expression in blood. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.922E-5 4.942E-3 3.555E-2
5.164E-2
 3 221
11 14695345-Table1b Mouse Viral Politi04 40genes DownRegulated GeneSigDB 7.497E-5 4.942E-3 3.555E-2
5.593E-2
 2 34
12 M14590 Genes up-regulated in MDA-MB-231 cells (breast cancer) after knockdown of ZEB1 [GeneID=6935] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.950E-5 4.942E-3 3.555E-2
5.931E-2
 2 35
13 19036130-TableS1b Mouse Viral Mendoza-Villanueva08 350genes GeneSigDB 1.199E-4 6.301E-3 4.532E-2
8.945E-2
 3 266
14 M6875 Genes up-regulated in preneoplastic mammary tissues and whose expression is maintained in tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.262E-4 6.301E-3 4.532E-2
9.412E-2
 2 44
15 M19432 Genes up-regulated during pubertal mammary gland development between week 4 and 5. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.267E-4 6.301E-3 4.532E-2
9.452E-2
 3 271
16 M16956 Genes up-regulated in hepatocellular carcinoma (HCC) cells with hepatic stem cell properties. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.441E-4 6.718E-3 4.832E-2
1.075E-1
 2 47
17 M16407 Genes in the expression cluster 'LT-HSC Shared': up-regulated in long term hematopoietic stem cells (LT-HSC) from adult bone marrow and fetal liver. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.728E-4 7.582E-3
5.454E-2
1.289E-1
 3 301
18 M2777 Genes whose expression peaked at 240 min after stimulation of MCF10A cells with serum. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.123E-4 8.799E-3
6.329E-2
1.584E-1
 2 57
19 M5370 Genes down-regulated in follicular thyroid adenoma (FTA) compared to other thyroid tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.023E-4 1.187E-2
8.538E-2
2.256E-1
 2 68
20 20421987-TableS4 Human Lung Hou10 518genes GeneSigDB 3.430E-4 1.280E-2
9.203E-2
2.559E-1
 3 380
21 18435859-Table1 Mouse Breast Piechocki08 140genes GeneSigDB 3.978E-4 1.413E-2
1.016E-1
2.967E-1
 2 78
22 M2299 Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout compared to normal 9.5 dpc embryos. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.176E-4 1.755E-2
1.262E-1
3.861E-1
 2 89
23 15297395-SuppTable1 Human Lymphoma Sriuranpong04 670genes Epithelium(N)Metaplastic/DisplasticLesions(R)Carcinoma(T) GeneSigDB 5.848E-4 1.897E-2
1.364E-1
4.362E-1
 3 456
24 17483316-Table2 Rat StemCell Stemmer07 134genes GeneSigDB 6.790E-4 1.986E-2
1.429E-1
5.065E-1
 2 102
25 15845616-SuppTable3 Mouse Uterine Jeong05 634genes GeneSigDB 6.873E-4 1.986E-2
1.429E-1
5.128E-1
 3 482
26 M1719 Genes enriched in choroid plexus cells in the brain identified through correlation-based searches seeded with the choroid plexus cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.923E-4 1.986E-2
1.429E-1
5.165E-1
 2 103
27 15297395-SuppTable3 Human Lymphoma Sriuranpong04 170genes GeneSigDB 8.618E-4 2.336E-2
1.680E-1
6.429E-1
 2 115
28 M13788 Genes up-regulated during pubertal mammary gland development between week 5 and 6. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.767E-4 2.336E-2
1.680E-1
6.540E-1
 2 116
29 15785748-Table2 Human Uterine Santin05 139genes GeneSigDB 1.001E-3 2.565E-2
1.845E-1
7.466E-1
 2 124
30 M5888 Cluster 2: late ATM [GeneID=472] dependent genes induced by ionizing radiation treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.049E-3 2.565E-2
1.845E-1
7.828E-1
 2 127
31 M4034 Genes expressed in at least one prostate cancer cell line but not in normal prostate epithelial cells or stromal cells MSigDB C2: CGP Curated Gene Sets (v6.0) 1.066E-3 2.565E-2
1.845E-1
7.951E-1
 2 128
32 M9016 Genes down-regulated in polysomal and total RNA samples from SW480 cells (primary colorectal carcinoma, CRC) compared to the SW620 cells (lymph node metastasis from the same individual). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.202E-3 2.802E-2
2.015E-1
8.965E-1
 2 136
33 M929 Genes up-regulated in colorectal adenoma compared to normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.255E-3 2.837E-2
2.040E-1
9.361E-1
 2 139
34 M2194 Genes down-regulated in liver samples of liver-specific knockout of HNF4A [GeneID=3172]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.440E-3 3.063E-2
2.203E-1
1.000E0
 2 149
35 M366 Up-regulated genes from the 324 genes identified by two analytical methods as changed in the mammary tumors induced by transgenic expression of ERBB2 [GeneID=2064]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.459E-3 3.063E-2
2.203E-1
1.000E0
 2 150
36 15785748-Table3 Human Uterine Santin05 178genes GeneSigDB 1.478E-3 3.063E-2
2.203E-1
1.000E0
 2 151
37 15284076-Table3 Human Lung not cancer Golpon04 4genes GeneSigDB 1.555E-3 3.094E-2
2.226E-1
1.000E0
 1 4
38 M11857 Genes down-regulated in HCT8/S11 cells (colon cancer) engineered to stably express NTN1 [GeneID=1630] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.617E-3 3.094E-2
2.226E-1
1.000E0
 2 158
39 M17424 Differentiation markers for normal alveolar epithelium cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.944E-3 3.094E-2
2.226E-1
1.000E0
 1 5
40 M2776 Cluster 1: genes up-regulated in lung tissue samples from mice with oncogenic form of KRAS [GeneID=3845] and inactivated PTEN [GeneID=5728]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.113E-3 3.094E-2
2.226E-1
1.000E0
 2 181
41 M8668 Genes up-regulated in monocytes (6h): untreated versus muramyl dipeptide [PubChem=11620162] andM. tuberculosis 19 kDa lipopeptide. MSigDB C7: Immunologic Signatures (v6.0) 2.253E-3 3.094E-2
2.226E-1
1.000E0
 2 187
42 M2827 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL21 [Gene ID=59067]. MSigDB C6: Oncogenic Signatures (v6.0) 2.277E-3 3.094E-2
2.226E-1
1.000E0
 2 188
43 M2768 Genes up-regulated during late stages of differentiation of embryoid bodies from J1 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 2.349E-3 3.094E-2
2.226E-1
1.000E0
 2 191
44 15208663-SuppTable1a Human Colon Kim04 285genes GeneSigDB 2.447E-3 3.094E-2
2.226E-1
1.000E0
 2 195
45 M8587 Genes down-regulated in macrophages versus dendritic cells sorted as ITGAX int [GeneID=3687] and EMR1 int [GeneID=2015]. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 3.094E-2
2.226E-1
1.000E0
 2 197
46 M10001 Genes up-regulated in dendritic cells with IFNAR1 [GeneID=3454] knockout: CD8A [GeneID=925] versus ITGAM+ [GeneID=3684]. MSigDB C7: Immunologic Signatures (v6.0) 2.497E-3 3.094E-2
2.226E-1
1.000E0
 2 197
47 M6294 Genes down-regulated in macrophages: untreated versus stimulated by IFNG [GeneID=3458] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.094E-2
2.226E-1
1.000E0
 2 198
48 M3200 Genes up-regulated in comparison of naive B cell versus dark zone germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.521E-3 3.094E-2
2.226E-1
1.000E0
 2 198
49 M8693 Genes up-regulated in monocytes (6h): M. tuberculosis 19 kDa lipopeptide versus M. tuberculosis 19 kDa lipopeptide and muramyl dipeptide [PubChem=11620162]. MSigDB C7: Immunologic Signatures (v6.0) 2.547E-3 3.094E-2
2.226E-1
1.000E0
 2 199
50 M5130 Genes down-regulated in comparison of ex vivo CD4 [GeneID=920] dendritic cells (DC) versus cultured CD4 [GeneID=920] DCs. MSigDB C7: Immunologic Signatures (v6.0) 2.572E-3 3.094E-2
2.226E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 1332 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingKidney e15.5 Medullary collecting duct 200 k3 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.632E-9 2.174E-6 1.690E-5 2.174E-6 4 43
2 gudmap kidney e15.5 Podocyte MafB 500 kidney e15.5 Podocyte MafB top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.542E-9 2.359E-6 1.833E-5 4.718E-6 6 413
3 gudmap developingKidney e15.5 early proxim tubul 1000 k2 DevelopingKidney e15.5 early proxim tubul emap-28005 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.974E-8 8.766E-6 6.813E-5 2.630E-5 4 79
4 gudmap developingKidney e15.5 Medullary collecting duct 500 k2 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.827E-8 1.274E-5 9.904E-5 5.097E-5 4 93
5 gudmap developingKidney e15.5 ureter tip flank cortic collct 500 k1 DevelopingKidney e15.5 ureter tip flank cortic collct emap-27752 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.071E-7 2.350E-5 1.826E-4 1.427E-4 4 120
6 gudmap developingKidney e15.5 cortic collect duct 1000 k3 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.223E-7 2.350E-5 1.826E-4 1.628E-4 4 124
7 PCBC ratio MESO-30 blastocyst vs MESO-30 fibroblast cfr-2X-p05 MESO-30 blastocyst vs MESO-30 fibroblast-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.735E-7 2.350E-5 1.826E-4 2.311E-4 5 375
8 PCBC ratio MESO-30 from-ESC vs MESO-30 from-OSKM - NLT cfr-2X-p05 Mesoderm Day 30-reprogram NA vs Mesoderm Day 30-reprogram OSKM - NLT-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.735E-7 2.350E-5 1.826E-4 2.311E-4 5 375
9 PCBC ratio MESO-30 from-ESC vs MESO-30 from-plasmid cfr-2X-p05 Mesoderm Day 30-method NA vs Mesoderm Day 30-method plasmid-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.735E-7 2.350E-5 1.826E-4 2.311E-4 5 375
10 gudmap developingKidney e15.5 early proxim tubul 500 DevelopingKidney e15.5 early proxim tubul emap-28005 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.190E-7 2.350E-5 1.826E-4 2.916E-4 5 393
11 gudmap developingLowerUrinaryTract e15.5 urothelium 500 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.245E-7 2.350E-5 1.826E-4 2.991E-4 5 395
12 gudmap kidney e10.5 UretericTrunk HoxB7 500 kidney e10.5 UretericTrunk HoxB7 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.274E-7 2.350E-5 1.826E-4 3.029E-4 5 396
13 gudmap kidney e10.5 UretericTip HoxB7 200 kidney e10.5 UretericTip HoxB7 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.293E-7 2.350E-5 1.826E-4 3.055E-4 4 145
14 gudmap developingKidney e15.5 S-shaped body 500 DevelopingKidney e15.5 S-shaped body emap-27855 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.573E-7 2.448E-5 1.903E-4 3.428E-4 5 406
15 gudmap developingKidney e15.5 Medullary collecting duct 200 DevelopingKidney e15.5 Medullary collecting duct emap-28063 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.404E-7 2.767E-5 2.150E-4 4.534E-4 4 160
16 gudmap developingKidney e15.5 S-shaped body 200 DevelopingKidney e15.5 S-shaped body emap-27855 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.578E-7 2.767E-5 2.150E-4 4.766E-4 4 162
17 gudmap developingKidney e11.5 ureteric bud 200 DevelopingKidney e11.5 ureteric bud emap-3844 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.578E-7 2.767E-5 2.150E-4 4.766E-4 4 162
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal fetal kidney EN-B/Kidney Normal fetal kidney EN11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal fetal kidney EN-B/Kidney Normal fetal kidney EN11 Adult, Development, and Cancer types 3.739E-7 2.767E-5 2.150E-4 4.980E-4 3 37
19 gudmap developingKidney e15.5 early proxim tubul 500 k2 DevelopingKidney e15.5 early proxim tubul emap-28005 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.396E-7 2.818E-5 2.190E-4 5.856E-4 3 39
20 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/4/1 Sample Type by Project: Shred 1/TCGA-Uterus/Uterine Carcinoma/Uterine Carcinosarcoma Heterologous Type/4/1 TCGA-Uterus 4.443E-7 2.818E-5 2.190E-4 5.918E-4 4 171
21 gudmap developingKidney e15.5 Medullary collecting duct 1000 k3 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.443E-7 2.818E-5 2.190E-4 5.918E-4 4 171
22 gudmap kidney P4 CapMesRenVes Crym 200 kidney P4 CapMesRenVes Crym top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.874E-7 2.951E-5 2.293E-4 6.492E-4 4 175
23 gudmap developingKidney e15.5 ureter tip flank cortic collct 1000 k4 DevelopingKidney e15.5 ureter tip flank cortic collct emap-27752 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.087E-7 3.525E-5 2.740E-4 8.108E-4 4 185
24 gudmap kidney e10.5 UretericTip HoxB7 k3 1000 kidney e10.5 UretericTip HoxB7 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.378E-6 7.645E-5 5.942E-4 1.835E-3 4 227
25 Facebase ST1 e10.5 RathkePouch 100 e10.5 RathkePouch top-relative-expression-ranked 100 FaceBase_ST1 2.291E-6 1.221E-4 9.487E-4 3.052E-3 3 67
26 Facebase ST1 e9.5 OticVesic 100 e9.5 OticVesic top-relative-expression-ranked 100 FaceBase_ST1 2.849E-6 1.460E-4 1.135E-3 3.795E-3 3 72
27 gudmap kidney e10.5 UretericTrunk HoxB7 k3 200 kidney e10.5 UretericTrunk HoxB7 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.096E-6 1.473E-4 1.145E-3 4.123E-3 3 74
28 Facebase ST1 e9.5 OlfacPlacod 100 e9.5 OlfacPlacod top-relative-expression-ranked 100 FaceBase_ST1 3.096E-6 1.473E-4 1.145E-3 4.123E-3 3 74
29 gudmap developingLowerUrinaryTract e15.5 Urothelium 1000 k5 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.219E-6 1.479E-4 1.149E-3 4.288E-3 4 281
30 gudmap RNAseq e15.5 Podocytes 2500 K4 gudmap RNAseq e15.5 Podocytes 2500 K4 Gudmap RNAseq 3.501E-6 1.554E-4 1.208E-3 4.663E-3 4 287
31 gudmap developingKidney e15.5 cortic collect duct 500 k2 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.773E-6 1.621E-4 1.260E-3 5.025E-3 3 79
32 Facebase ST1 e10.5 ColumEpith Maxil 100 e10.5 ColumEpith Maxil top-relative-expression-ranked 100 FaceBase_ST1 4.069E-6 1.694E-4 1.316E-3 5.419E-3 3 81
33 Facebase ST1 e10.5 Nasal Pit 100 e10.5 Nasal Pit top-relative-expression-ranked 100 FaceBase_ST1 4.222E-6 1.704E-4 1.325E-3 5.624E-3 3 82
34 gudmap developingKidney e11.5 ureteric bud 100 DevelopingKidney e11.5 ureteric bud emap-3844 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.706E-6 1.844E-4 1.433E-3 6.269E-3 3 85
35 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/epithelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Trachea/epithelial cell Tabula Muris Consortium 5.048E-6 1.921E-4 1.493E-3 6.724E-3 3 87
36 Facebase ST1 e10.5 RathkePouch 500 1 e10.5 RathkePouch top-relative-expression-ranked 500 1 FaceBase_ST1 5.407E-6 2.000E-4 1.555E-3 7.202E-3 3 89
37 facebase RNAseq e9.5 OlfPlac 2500 K2 facebase RNAseq e9.5 OlfPlac 2500 K2 Gudmap RNAseq 6.014E-6 2.165E-4 1.683E-3 8.011E-3 4 329
38 Facebase RNAseq e10.5 Olfactory Pit 100 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 100 FaceBase_RNAseq 7.681E-6 2.692E-4 2.092E-3 1.023E-2 3 100
39 Facebase RNAseq e10.5 Olfactory Pit 500 K1 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 8.643E-6 2.952E-4 2.294E-3 1.151E-2 3 104
40 gudmap kidney e10.5 UretericTip HoxB7 500 kidney e10.5 UretericTip HoxB7 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.108E-5 3.689E-4 2.867E-3 1.476E-2 4 384
41 gudmap developingLowerUrinaryTract e13.5 bladder epithelial cells 500 DevelopingLowerUrinaryTract e13.5 bladder epithelial cells emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.214E-5 3.761E-4 2.923E-3 1.617E-2 4 393
42 gudmap developingKidney e15.5 Medullary collecting duct 500 DevelopingKidney e15.5 Medullary collecting duct emap-28063 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.226E-5 3.761E-4 2.923E-3 1.633E-2 4 394
43 gudmap kidney P4 CapMesRenVes Crym 500 kidney P4 CapMesRenVes Crym top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.288E-5 3.761E-4 2.923E-3 1.716E-2 4 399
44 gudmap developingLowerUrinaryTract e15.5 Urothelium 500 k1 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.296E-5 3.761E-4 2.923E-3 1.726E-2 3 119
45 gudmap developingKidney e11.5 ureteric bud 500 DevelopingKidney e11.5 ureteric bud emap-3844 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.314E-5 3.761E-4 2.923E-3 1.750E-2 4 401
46 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.327E-5 3.761E-4 2.923E-3 1.768E-2 4 402
47 facebase RNAseq e10.5 OlfacPit 2500 K1 facebase RNAseq e10.5 OlfacPit 2500 K1 Gudmap RNAseq 1.327E-5 3.761E-4 2.923E-3 1.768E-2 4 402
48 gudmap developingKidney e15.5 ureter tip 500 flank cortic collct DevelopingKidney e15.5 ureter tip flank cortic collct emap-27752 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.380E-5 3.829E-4 2.976E-3 1.838E-2 4 406
49 Facebase ST1 e11.5 Emin MedNasl SingCel 500 2 e11.5 Emin MedNasl SingCel top-relative-expression-ranked 500 2 FaceBase_ST1 1.466E-5 3.985E-4 3.097E-3 1.952E-2 3 124
50 gudmap developingKidney e15.5 1000 k2 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.689E-5 4.499E-4 3.497E-3 2.250E-2 3 130
Show 45 more annotations

15: Computational [Display Chart] 7 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19525 MODULE 139 Genes in the cancer module 139. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.252E-3 1.868E-2
7.127E-2
 3.130E-2 2 79
2 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.184E-3 1.868E-2
7.127E-2
5.460E-2
 3 416
3 M8449 MODULE 180 Genes in the cancer module 180. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.862E-3 1.868E-2
7.127E-2
7.156E-2
 2 120
4 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.988E-3 1.868E-2
7.127E-2
7.471E-2
 3 464
5 M16667 MODULE 342 Genes in the cancer module 342. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.854E-3 4.427E-2
1.689E-1
2.214E-1
 2 214

16: MicroRNA [Display Chart] 9 input genes in category / 164 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6124:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.222E-4 3.302E-2
1.876E-1
 3.643E-2 2 181
2 hsa-miR-3148:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.027E-4 3.302E-2
1.876E-1
6.604E-2
 2 244
3 hsa-miR-1295a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.731E-3 4.023E-2
2.285E-1
6.120E-1
 1 30
4 hsa-miR-4305:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.724E-3 4.023E-2
2.285E-1
7.748E-1
 1 38
5 hsa-miR-1243:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 4.023E-2
2.285E-1
8.155E-1
 1 40
6 hsa-miR-5579-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.345E-3 4.023E-2
2.285E-1
8.765E-1
 1 43
7 hsa-miR-1228-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.593E-3 4.023E-2
2.285E-1
9.172E-1
 1 45
8 hsa-miR-5704:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 4.023E-2
2.285E-1
9.375E-1
 1 46
9 hsa-miR-3670:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.964E-3 4.023E-2
2.285E-1
9.782E-1
 1 48
10 hsa-miR-345-5p:Functional MTI Functional MTI miRTarbase 6.336E-3 4.023E-2
2.285E-1
1.000E0
 1 51
11 hsa-miR-4777-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.832E-3 4.023E-2
2.285E-1
1.000E0
 1 55
12 hsa-miR-3117-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.955E-3 4.023E-2
2.285E-1
1.000E0
 1 56
13 hsa-miR-5003-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.451E-3 4.023E-2
2.285E-1
1.000E0
 1 60
14 hsa-miR-523-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
15 hsa-miR-526a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
16 hsa-miR-519c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
17 hsa-miR-520c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
18 hsa-miR-518f-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
19 hsa-miR-518d-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
20 hsa-miR-518e-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
21 hsa-miR-519a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
22 hsa-miR-519b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.023E-2
2.285E-1
1.000E0
 1 61
23 hsa-miR-522-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.698E-3 4.023E-2
2.285E-1
1.000E0
 1 62
24 hsa-miR-301b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.069E-3 4.023E-2
2.285E-1
1.000E0
 1 65
25 hsa-miR-1285-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.193E-3 4.023E-2
2.285E-1
1.000E0
 1 66
26 hsa-miR-653-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.440E-3 4.023E-2
2.285E-1
1.000E0
 1 68
27 hsa-miR-301a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.440E-3 4.023E-2
2.285E-1
1.000E0
 1 68
28 hsa-miR-299-3p:Functional MTI Functional MTI miRTarbase 8.811E-3 4.023E-2
2.285E-1
1.000E0
 1 71
29 hsa-miR-5100:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.935E-3 4.023E-2
2.285E-1
1.000E0
 1 72
30 ACACTCC,MIR-122A:MSigDB ACACTCC,MIR-122A:MSigDB MSigDB 9.058E-3 4.023E-2
2.285E-1
1.000E0
 1 73
31 hsa-miR-4491:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.058E-3 4.023E-2
2.285E-1
1.000E0
 1 73
32 hsa-miR-4657:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.058E-3 4.023E-2
2.285E-1
1.000E0
 1 73
33 hsa-miR-4461:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.182E-3 4.023E-2
2.285E-1
1.000E0
 1 74
34 hsa-miR-4663:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.800E-3 4.023E-2
2.285E-1
1.000E0
 1 79
35 hsa-miR-15a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.800E-3 4.023E-2
2.285E-1
1.000E0
 1 79
36 hsa-miR-337-3p:Functional MTI Functional MTI miRTarbase 1.005E-2 4.023E-2
2.285E-1
1.000E0
 1 81
37 hsa-miR-4717-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.005E-2 4.023E-2
2.285E-1
1.000E0
 1 81
38 hsa-miR-378g:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.017E-2 4.023E-2
2.285E-1
1.000E0
 1 82
39 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.029E-2 4.023E-2
2.285E-1
1.000E0
 1 83
40 hsa-miR-376c-3p:Functional MTI Functional MTI miRTarbase 1.042E-2 4.023E-2
2.285E-1
1.000E0
 1 84
41 hsa-miR-10b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.054E-2 4.023E-2
2.285E-1
1.000E0
 1 85
42 hsa-miR-4802-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.054E-2 4.023E-2
2.285E-1
1.000E0
 1 85
43 hsa-miR-1224-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.023E-2
2.285E-1
1.000E0
 1 91
44 hsa-miR-6833-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.023E-2
2.285E-1
1.000E0
 1 91
45 hsa-miR-576-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.023E-2
2.285E-1
1.000E0
 1 91
46 CCAGGGG,MIR-331:MSigDB CCAGGGG,MIR-331:MSigDB MSigDB 1.153E-2 4.023E-2
2.285E-1
1.000E0
 1 93
47 hsa-miR-212-3p:Functional MTI Functional MTI miRTarbase 1.165E-2 4.023E-2
2.285E-1
1.000E0
 1 94
48 hsa-miR-3620-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.177E-2 4.023E-2
2.285E-1
1.000E0
 1 95
49 hsa-miR-548u:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.251E-2 4.101E-2
2.329E-1
1.000E0
 1 101
50 hsa-miR-7161-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.276E-2 4.101E-2
2.329E-1
1.000E0
 1 103
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 1561 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID016122585 2ntf Stitch 1.031E-13 1.610E-10 1.277E-9 1.610E-10 5 24
2 CID000003383 D& Stitch 6.510E-10 3.797E-7 3.011E-6 1.016E-6 4 36
3 CID000011510 N-hydroxyurethane Stitch 7.297E-10 3.797E-7 3.011E-6 1.139E-6 4 37
4 CID000001930 elaidamide Stitch 2.336E-9 9.117E-7 7.230E-6 3.647E-6 4 49
5 CID000001293 R1-methanandamide Stitch 3.226E-9 1.007E-6 7.988E-6 5.036E-6 4 53
6 CID004633871 AC1NDYYW Stitch 5.366E-9 1.396E-6 1.107E-5 8.377E-6 4 60
7 CID000003230 18b-glycyrrhetic acid Stitch 2.014E-8 4.491E-6 3.562E-5 3.144E-5 4 83
8 CID000024918 lanthanum nitrate Stitch 4.086E-8 7.973E-6 6.323E-5 6.378E-5 3 19
9 CID000004247 monodansylcadaverine Stitch 6.773E-8 1.175E-5 9.316E-5 1.057E-4 4 112
10 CID000498506 dihydroxy(oxo)azanium Stitch 8.526E-8 1.299E-5 1.031E-4 1.331E-4 3 24
11 ctd:C006551 2-amino-2-methyl-1-propanol CTD 9.157E-8 1.299E-5 1.031E-4 1.429E-4 5 345
12 CID000011427 methionine hydroxy analog Stitch 1.095E-7 1.424E-5 1.129E-4 1.709E-4 3 26
13 ctd:D010365 Patulin CTD 2.751E-7 3.303E-5 2.620E-4 4.295E-4 3 35
14 ctd:C042577 diallyl trisulfide CTD 3.457E-7 3.855E-5 3.057E-4 5.397E-4 4 168
15 ctd:C099089 illite CTD 4.140E-7 4.308E-5 3.416E-4 6.462E-4 2 3
16 ctd:C007262 deoxynivalenol CTD 4.866E-7 4.747E-5 3.765E-4 7.596E-4 5 483
17 ctd:C028009 diallyl disulfide CTD 1.098E-6 1.006E-4 7.981E-4 1.715E-3 3 55
18 ctd:C005705 sanguinarine CTD 1.160E-6 1.006E-4 7.981E-4 1.811E-3 3 56
19 CID000081462 BT-B Stitch 1.510E-6 1.179E-4 9.348E-4 2.357E-3 4 243
20 CID000000453 hexitol Stitch 1.510E-6 1.179E-4 9.348E-4 2.357E-3 4 243
21 CID000007452 dinitrobenzene Stitch 2.595E-6 1.929E-4 1.530E-3 4.051E-3 3 73
22 ctd:C011730 clay CTD 2.895E-6 2.054E-4 1.629E-3 4.520E-3 2 7
23 ctd:D006886 Hydroxychloroquine CTD 4.961E-6 3.367E-4 2.670E-3 7.745E-3 2 9
24 ctd:C100082 malaoxon CTD 7.577E-6 4.928E-4 3.908E-3 1.183E-2 2 11
25 CID000388945 epo906 Stitch 9.951E-6 6.214E-4 4.928E-3 1.553E-2 3 114
26 CID000002954 4',6-diamidino-2-phenylindole Stitch 1.132E-5 6.797E-4 5.390E-3 1.767E-2 3 119
27 CID000024763 inulin Stitch 1.580E-5 8.889E-4 7.050E-3 2.467E-2 3 133
28 CID011287714 (2R)-2-amino-5-[[amino-(2-methoxyethylamino)methylene]amino]valeric acid Stitch 1.651E-5 8.889E-4 7.050E-3 2.578E-2 2 16
29 ctd:D010208 Papaverine CTD 1.651E-5 8.889E-4 7.050E-3 2.578E-2 2 16
30 CID000000689 AC1Q6S3U Stitch 2.696E-5 1.403E-3 1.113E-2 4.209E-2 3 159
31 ctd:D004178 Diquat CTD 2.958E-5 1.489E-3 1.181E-2 4.617E-2 3 164
32 CID011966247 Cytochrome Cc(3) Stitch 4.463E-5 2.177E-3 1.727E-2
6.968E-2
 2 26
33 ctd:D007455 Iodine CTD 6.380E-5 3.018E-3 2.393E-2
9.959E-2
 2 31
34 CID004145138 AC1N5HQS Stitch 7.241E-5 3.325E-3 2.637E-2
1.130E-1
 2 33
35 ctd:C070055 2,3',4,4',5-pentachlorobiphenyl CTD 9.126E-5 4.070E-3 3.228E-2
1.425E-1
 2 37
36 ctd:C569107 1-(2-chlorobenzyl)-5'-phenyl-3'H-spiro(indoline-3,2'-(1,3,4)thiadiazol)-2-one CTD 1.236E-4 5.359E-3 4.250E-2
1.929E-1
 2 43
37 ctd:D017965 gamma-Linolenic Acid CTD 1.294E-4 5.461E-3 4.331E-2
2.021E-1
 2 44
38 CID000087177 maltulose Stitch 1.354E-4 5.564E-3 4.412E-2
2.114E-1
 2 45
39 CID000065702 trofosfamide Stitch 1.542E-4 6.173E-3 4.895E-2
2.407E-1
 2 48
40 CID000025423 monochloramine Stitch 1.811E-4 7.069E-3
5.606E-2
2.828E-1
 2 52
41 CID000008830 DNBS Stitch 2.255E-4 8.587E-3
6.810E-2
3.521E-1
 2 58
42 CID000372705 AC1L85AO Stitch 3.011E-4 1.119E-2
8.876E-2
4.700E-1
 2 67
43 CID004636205 AC1NE3ZI Stitch 3.194E-4 1.159E-2
9.195E-2
4.985E-1
 2 69
44 ctd:C049864 ginsenoside Re CTD 3.382E-4 1.200E-2
9.514E-2
5.279E-1
 2 71
45 CID000550880 1,4-pentanediamine Stitch 3.773E-4 1.230E-2
9.756E-2
5.890E-1
 2 75
46 CID006338557 O-EC Stitch 3.874E-4 1.230E-2
9.756E-2
6.048E-1
 2 76
47 ctd:C024948 actinidine CTD 3.940E-4 1.230E-2
9.756E-2
6.151E-1
 1 1
48 ctd:C087758 difructose anhydride III CTD 3.940E-4 1.230E-2
9.756E-2
6.151E-1
 1 1
49 ctd:D001974 Bromosuccinimide CTD 3.940E-4 1.230E-2
9.756E-2
6.151E-1
 1 1
50 ctd:C120646 luteolin 4'-O-glucoside CTD 3.940E-4 1.230E-2
9.756E-2
6.151E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 181 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0021167 Incontinence DisGeNET BeFree 2.367E-9 2.142E-7 1.238E-6 4.285E-7 3 6
2 C0339273 Corneal dystrophy, Lattice type 3 DisGeNET Curated 2.367E-9 2.142E-7 1.238E-6 4.285E-7 3 6
3 C0677055 CARCINOMA OF VULVA DisGeNET BeFree 6.470E-9 3.904E-7 2.256E-6 1.171E-6 4 45
4 C1843355 ICHTHYOSIS, LEUKOCYTE VACUOLES, ALOPECIA, AND SCLEROSING CHOLANGITIS DisGeNET Curated 8.224E-7 3.721E-5 2.150E-4 1.488E-4 2 3
5 C0008373 Cholesteatoma DisGeNET Curated 1.504E-5 5.445E-4 3.146E-3 2.723E-3 2 11
6 C0008313 Cholangitis, Sclerosing DisGeNET Curated 2.132E-5 6.431E-4 3.716E-3 3.859E-3 2 13
7 C2004489 Regurgitation DisGeNET BeFree 5.183E-5 1.340E-3 7.744E-3 9.381E-3 2 20
8 C0022104 Irritable Bowel Syndrome DisGeNET Curated 8.324E-5 1.883E-3 1.088E-2 1.507E-2 3 165
9 C0010276 Craniopharyngioma DisGeNET Curated 9.555E-5 1.922E-3 1.110E-2 1.729E-2 2 27
10 C0553665 Skin endocrine disorder DisGeNET BeFree 1.451E-4 2.438E-3 1.409E-2 2.626E-2 3 199
11 C1176475 Ductal Carcinoma DisGeNET Curated 1.517E-4 2.438E-3 1.409E-2 2.745E-2 3 202
12 C0393819 Polyradiculoneuropathy, Chronic Inflammatory Demyelinating DisGeNET BeFree 1.616E-4 2.438E-3 1.409E-2 2.925E-2 2 35
13 C0349530 Early gastric cancer DisGeNET BeFree 2.010E-4 2.799E-3 1.617E-2 3.639E-2 2 39
14 C0206624 Hepatoblastoma DisGeNET Curated 2.197E-4 2.841E-3 1.641E-2 3.977E-2 3 229
15 C0020758 Congenital ichthyosis DisGeNET Curated 3.052E-4 3.683E-3 2.128E-2
5.524E-2
 2 48
16 C0442874 Neuropathy DisGeNET Curated 3.528E-4 3.866E-3 2.234E-2
6.387E-2
 3 269
17 C2919945 Cavernous Hemangioma of Brain DisGeNET Curated 3.865E-4 3.866E-3 2.234E-2
6.996E-2
 2 54
18 cv:C1843355 Ichthyosis, leukocyte vacuoles, alopecia, and sclerosing cholangitis Clinical Variations 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
19 OMIN:606824 GLUCOSE/GALACTOSE MALABSORPTION; GGM OMIM 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
20 C2931662 Baraitser Brett Piesowicz syndrome DisGeNET Curated 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
21 cv:C0268186 Congenital glucose-galactose malabsorption Clinical Variations 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
22 cv:C3489725 Band-like calcification with simplified gyration and polymicrogyria Clinical Variations 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
23 OMIN:251290 BAND-LIKE CALCIFICATION WITH SIMPLIFIED GYRATION AND POLYMICROGYRIA; BLCPMG OMIM 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
24 C3151000 HEMORRHAGIC DESTRUCTION OF THE BRAIN, SUBEPENDYMAL CALCIFICATION, AND CATARACTS DisGeNET Curated 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
25 OMIN:607626 ICHTHYOSIS, LEUKOCYTE VACUOLES, ALOPECIA, AND SCLEROSING CHOLANGITIS OMIM 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
26 cv:C3151000 Hemorrhagic destruction of the brain, subependymal calcification, and cataracts Clinical Variations 5.554E-4 3.866E-3 2.234E-2
1.005E-1
 1 1
27 C0020757 Ichthyoses DisGeNET Curated 6.310E-4 4.230E-3 2.444E-2
1.142E-1
 2 69
28 C0238339 Hereditary pancreatitis DisGeNET Curated 6.869E-4 4.287E-3 2.477E-2
1.243E-1
 2 72
29 C4082937 Necrotizing enterocolitis in fetus OR newborn DisGeNET BeFree 6.869E-4 4.287E-3 2.477E-2
1.243E-1
 2 72
30 C0349555 Vaginal intraepithelial neoplasia grade 2 DisGeNET BeFree 1.110E-3 6.091E-3 3.520E-2
2.010E-1
 1 2
31 C0235840 Neonatal diarrhea DisGeNET BeFree 1.110E-3 6.091E-3 3.520E-2
2.010E-1
 1 2
32 C1843359 Orthokeratosis DisGeNET Curated 1.110E-3 6.091E-3 3.520E-2
2.010E-1
 1 2
33 C3489725 Pseudo-TORCH syndrome DisGeNET Curated 1.110E-3 6.091E-3 3.520E-2
2.010E-1
 1 2
34 C0206687 Carcinoma, Endometrioid DisGeNET Curated 1.426E-3 7.592E-3 4.387E-2
2.581E-1
 2 104
35 C0349554 Vaginal intraepithelial neoplasia grade 1 DisGeNET BeFree 1.665E-3 7.932E-3 4.584E-2
3.014E-1
 1 3
36 C1112601 Hypertonic dehydration DisGeNET Curated 1.665E-3 7.932E-3 4.584E-2
3.014E-1
 1 3
37 C0752244 Rathke Cleft Cysts DisGeNET BeFree 1.665E-3 7.932E-3 4.584E-2
3.014E-1
 1 3
38 C1847425 Abnormal glucose oral tolerance test DisGeNET Curated 1.665E-3 7.932E-3 4.584E-2
3.014E-1
 1 3
39 C0007621 Neoplastic Cell Transformation DisGeNET Curated 1.740E-3 8.074E-3 4.666E-2
3.149E-1
 2 115
40 C1153706 Endometrial adenocarcinoma DisGeNET BeFree 1.987E-3 8.990E-3
5.195E-2
3.596E-1
 2 123
41 C0566602 Primary sclerosing cholangitis DisGeNET Curated 2.149E-3 9.132E-3
5.277E-2
3.890E-1
 2 128
42 C3245525 Familial renal glucosuria DisGeNET BeFree 2.220E-3 9.132E-3
5.277E-2
4.018E-1
 1 4
43 C0334036 Apocrine metaplasia DisGeNET BeFree 2.220E-3 9.132E-3
5.277E-2
4.018E-1
 1 4
44 C1858051 NORTH AMERICAN INDIAN CHILDHOOD CIRRHOSIS DisGeNET Curated 2.220E-3 9.132E-3
5.277E-2
4.018E-1
 1 4
45 C1873509 Hypotrichosis of the scalp DisGeNET Curated 3.328E-3 1.315E-2
7.599E-2
6.024E-1
 1 6
46 C0010709 Cyst DisGeNET Curated 3.373E-3 1.315E-2
7.599E-2
6.106E-1
 2 161
47 C1336076 Sporadic Breast Carcinoma DisGeNET BeFree 3.415E-3 1.315E-2
7.599E-2
6.180E-1
 2 162
48 C0206682 Follicular thyroid carcinoma DisGeNET Curated 3.753E-3 1.405E-2
8.120E-2
6.792E-1
 2 170
49 C3495427 Fanconi-Bickel Syndrome DisGeNET Curated 3.882E-3 1.405E-2
8.120E-2
7.026E-1
 1 7
50 C0268186 Congenital glucose-galactose malabsorption DisGeNET Curated 3.882E-3 1.405E-2
8.120E-2
7.026E-1
 1 7
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