|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
11003834
|
Positive and negative interactions of GDNF, NTN and ART in developing sensory neuron subpopulations, and their collaboration with neurotrophins.
|
Pubmed
|
3.990E-17
|
9.854E-14
|
8.950E-13
|
1.971E-13
|
5
|
7
|
2
|
9448325
|
Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptor.
|
Pubmed
|
3.990E-17
|
9.854E-14
|
8.950E-13
|
1.971E-13
|
5
|
7
|
3
|
22855506
|
Differential RET signaling pathways drive development of the enteric lymphoid and nervous systems.
|
Pubmed
|
1.504E-15
|
2.476E-12
|
2.248E-11
|
7.427E-12
|
5
|
12
|
4
|
10712625
|
A dynamic regulation of GDNF-family receptors correlates with a specific trophic dependency of cranial motor neuron subpopulations during development.
|
Pubmed
|
1.209E-13
|
1.195E-10
|
1.085E-9
|
5.973E-10
|
4
|
6
|
5
|
9786421
|
Neurturin mRNA expression suggests roles in trigeminal innervation of the first branchial arch and in tooth formation.
|
Pubmed
|
1.209E-13
|
1.195E-10
|
1.085E-9
|
5.973E-10
|
4
|
6
|
6
|
15204970
|
The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction.
|
Pubmed
|
2.821E-13
|
1.991E-10
|
1.808E-9
|
1.394E-9
|
4
|
7
|
7
|
17322904
|
Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.
|
Pubmed
|
2.821E-13
|
1.991E-10
|
1.808E-9
|
1.394E-9
|
4
|
7
|
8
|
10331972
|
A rapid and dynamic regulation of GDNF-family ligands and receptors correlate with the developmental dependency of cutaneous sensory innervation.
|
Pubmed
|
1.015E-12
|
6.268E-10
|
5.693E-9
|
5.015E-9
|
4
|
9
|
9
|
10482239
|
GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion.
|
Pubmed
|
3.987E-12
|
2.188E-9
|
1.987E-8
|
1.969E-8
|
4
|
12
|
10
|
12810600
|
Crucial role of TrkB ligands in the survival and phenotypic differentiation of developing locus coeruleus noradrenergic neurons.
|
Pubmed
|
8.059E-12
|
3.980E-9
|
3.615E-8
|
3.980E-8
|
4
|
14
|
11
|
19580811
|
Autocrine regulation of early embryonic development by the artemin-GFRA3 (GDNF family receptor-alpha 3) signaling system in mice.
|
Pubmed
|
3.080E-11
|
1.268E-8
|
1.151E-7
|
1.521E-7
|
3
|
3
|
12
|
18313696
|
Altered expression of neurotrophic factors in patients with major depression.
|
Pubmed
|
3.080E-11
|
1.268E-8
|
1.151E-7
|
1.521E-7
|
3
|
3
|
13
|
9415430
|
Expression of GDNF and its receptors in developing tooth is developmentally regulated and suggests multiple roles in innervation and organogenesis.
|
Pubmed
|
1.232E-10
|
3.380E-8
|
3.070E-7
|
6.084E-7
|
3
|
4
|
14
|
23884957
|
Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain.
|
Pubmed
|
1.232E-10
|
3.380E-8
|
3.070E-7
|
6.084E-7
|
3
|
4
|
15
|
17490619
|
Crosstalk between VEGF-A/VEGFR2 and GDNF/RET signaling pathways.
|
Pubmed
|
1.232E-10
|
3.380E-8
|
3.070E-7
|
6.084E-7
|
3
|
4
|
16
|
9749804
|
GFRalpha-3, a protein related to GFRalpha-1, is expressed in developing peripheral neurons and ensheathing cells.
|
Pubmed
|
1.232E-10
|
3.380E-8
|
3.070E-7
|
6.084E-7
|
3
|
4
|
17
|
9452475
|
Identification and characterization of GFRalpha-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family.
|
Pubmed
|
1.232E-10
|
3.380E-8
|
3.070E-7
|
6.084E-7
|
3
|
4
|
18
|
9576965
|
GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family.
|
Pubmed
|
1.232E-10
|
3.380E-8
|
3.070E-7
|
6.084E-7
|
3
|
4
|
19
|
27571008
|
Visceral motor neuron diversity delineates a cellular basis for nipple- and pilo-erection muscle control.
|
Pubmed
|
2.525E-10
|
5.849E-8
|
5.312E-7
|
1.247E-6
|
4
|
31
|
20
|
10829012
|
Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
21
|
10415156
|
Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
22
|
9182803
|
TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
23
|
9334423
|
Neurturin and glial cell line-derived neurotrophic factor receptor-beta (GDNFR-beta), novel proteins related to GDNF and GDNFR-alpha with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in peripheral organs.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
24
|
25275256
|
Circulating levels of neurotrophic factors in autism spectrum disorders.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
25
|
18657279
|
Effects of NGF, NT-3 and GDNF family members on neurite outgrowth and migration from pelvic ganglia from embryonic and newborn mice.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
26
|
9407096
|
GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family.
|
Pubmed
|
3.079E-10
|
5.849E-8
|
5.312E-7
|
1.521E-6
|
3
|
5
|
27
|
23525041
|
Layer V cortical neurons require microglial support for survival during postnatal development.
|
Pubmed
|
4.723E-10
|
8.639E-8
|
7.846E-7
|
2.332E-6
|
4
|
36
|
28
|
16953113
|
Downregulation of neurotrophic factors in the brain of a mouse model of Gaucher disease; implications for neuronal loss in Gaucher disease.
|
Pubmed
|
6.157E-10
|
1.014E-7
|
9.206E-7
|
3.041E-6
|
3
|
6
|
29
|
10860579
|
Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development.
|
Pubmed
|
6.157E-10
|
1.014E-7
|
9.206E-7
|
3.041E-6
|
3
|
6
|
30
|
12397373
|
Expression patterns of neurotrophic factor mRNAs in developing human teeth.
|
Pubmed
|
6.157E-10
|
1.014E-7
|
9.206E-7
|
3.041E-6
|
3
|
6
|
31
|
25525881
|
The cellular and molecular basis of direction selectivity of Aδ-LTMRs.
|
Pubmed
|
1.077E-9
|
1.612E-7
|
1.464E-6
|
5.321E-6
|
3
|
7
|
32
|
16497798
|
Ablation of persephin receptor glial cell line-derived neurotrophic factor family receptor alpha4 impairs thyroid calcitonin production in young mice.
|
Pubmed
|
1.077E-9
|
1.612E-7
|
1.464E-6
|
5.321E-6
|
3
|
7
|
33
|
18417692
|
Neurturin-mediated ret activation is required for retinal function.
|
Pubmed
|
1.077E-9
|
1.612E-7
|
1.464E-6
|
5.321E-6
|
3
|
7
|
34
|
16193506
|
Presence of neurotrophic factors in skeletal muscle correlates with survival of spinal cord motor neurons.
|
Pubmed
|
1.723E-9
|
2.503E-7
|
2.274E-6
|
8.511E-6
|
3
|
8
|
35
|
12917363
|
Neuromuscular development after the prevention of naturally occurring neuronal death by Bax deletion.
|
Pubmed
|
2.584E-9
|
3.359E-7
|
3.051E-6
|
1.276E-5
|
3
|
9
|
36
|
12668632
|
GDNF availability determines enteric neuron number by controlling precursor proliferation.
|
Pubmed
|
2.584E-9
|
3.359E-7
|
3.051E-6
|
1.276E-5
|
3
|
9
|
37
|
20139349
|
Neural crest cell origin and signals for intrinsic neurogenesis in the mammalian respiratory tract.
|
Pubmed
|
2.584E-9
|
3.359E-7
|
3.051E-6
|
1.276E-5
|
3
|
9
|
38
|
25838128
|
Cis and trans RET signaling control the survival and central projection growth of rapidly adapting mechanoreceptors.
|
Pubmed
|
2.584E-9
|
3.359E-7
|
3.051E-6
|
1.276E-5
|
3
|
9
|
39
|
11069590
|
Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo.
|
Pubmed
|
3.691E-9
|
4.240E-7
|
3.851E-6
|
1.823E-5
|
3
|
10
|
40
|
20219210
|
Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.
|
Pubmed
|
3.691E-9
|
4.240E-7
|
3.851E-6
|
1.823E-5
|
3
|
10
|
41
|
18203754
|
Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders.
|
Pubmed
|
3.691E-9
|
4.240E-7
|
3.851E-6
|
1.823E-5
|
3
|
10
|
42
|
15748846
|
GDNF and GFRalpha1 promote differentiation and tangential migration of cortical GABAergic neurons.
|
Pubmed
|
3.691E-9
|
4.240E-7
|
3.851E-6
|
1.823E-5
|
3
|
10
|
43
|
18216204
|
Retrograde signaling onto Ret during motor nerve terminal maturation.
|
Pubmed
|
3.691E-9
|
4.240E-7
|
3.851E-6
|
1.823E-5
|
3
|
10
|
44
|
24107967
|
GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors.
|
Pubmed
|
5.075E-9
|
5.449E-7
|
4.949E-6
|
2.506E-5
|
3
|
11
|
45
|
18305247
|
The neurotrophic effects of glial cell line-derived neurotrophic factor on spinal motoneurons are restricted to fusimotor subtypes.
|
Pubmed
|
5.075E-9
|
5.449E-7
|
4.949E-6
|
2.506E-5
|
3
|
11
|
46
|
11044402
|
Development of cranial parasympathetic ganglia requires sequential actions of GDNF and neurturin.
|
Pubmed
|
5.075E-9
|
5.449E-7
|
4.949E-6
|
2.506E-5
|
3
|
11
|
47
|
29615468
|
Intrahepatic bile ducts guide establishment of the intrahepatic nerve network in developing and regenerating mouse liver.
|
Pubmed
|
1.119E-8
|
1.176E-6
|
1.068E-5
|
5.526E-5
|
3
|
14
|
48
|
29031500
|
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
|
Pubmed
|
1.313E-8
|
1.351E-6
|
1.227E-5
|
6.487E-5
|
5
|
246
|
49
|
24516396
|
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
|
Pubmed
|
1.398E-8
|
1.381E-6
|
1.254E-5
|
6.906E-5
|
3
|
15
|
50
|
20064391
|
Molecular identification of rapidly adapting mechanoreceptors and their developmental dependence on ret signaling.
|
Pubmed
|
1.398E-8
|
1.381E-6
|
1.254E-5
|
6.906E-5
|
3
|
15
|