|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
15760897
|
Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress.
|
Pubmed
|
2.879E-8
|
9.544E-6
|
6.366E-5
|
1.273E-5
|
2
|
2
|
2
|
18403318
|
Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.
|
Pubmed
|
8.637E-8
|
9.544E-6
|
6.366E-5
|
3.818E-5
|
2
|
3
|
3
|
24440759
|
The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: new players in cholesterol metabolism.
|
Pubmed
|
8.637E-8
|
9.544E-6
|
6.366E-5
|
3.818E-5
|
2
|
3
|
4
|
20600027
|
Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis.
|
Pubmed
|
8.637E-8
|
9.544E-6
|
6.366E-5
|
3.818E-5
|
2
|
3
|
5
|
12011452
|
The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6.
|
Pubmed
|
1.727E-7
|
1.527E-5
|
1.018E-4
|
7.635E-5
|
2
|
4
|
6
|
12011453
|
Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain.
|
Pubmed
|
4.318E-7
|
3.181E-5
|
2.121E-4
|
1.908E-4
|
2
|
6
|
7
|
24652767
|
Histopathology reveals correlative and unique phenotypes in a high-throughput mouse phenotyping screen.
|
Pubmed
|
2.969E-5
|
5.587E-4
|
3.726E-3
|
1.312E-2
|
2
|
46
|
8
|
16783635
|
Quantitative trait loci for body size components in mice.
|
Pubmed
|
1.248E-4
|
5.587E-4
|
3.726E-3
|
5.518E-2
|
2
|
94
|
9
|
16862168
|
The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
10
|
20634475
|
p122 protein enhances intracellular calcium increase to acetylcholine: its possible role in the pathogenesis of coronary spastic angina.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
11
|
17888903
|
Morphological changes and nuclear translocation of DLC1 tumor suppressor protein precede apoptosis in human non-small cell lung carcinoma cells.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
12
|
14661059
|
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
13
|
24557030
|
DLC1 expression is reduced in human cutaneous melanoma and correlates with patient survival.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
14
|
24604602
|
Tumor suppressor DLC-1 induces apoptosis and inhibits the growth and invasion of colon cancer cells through the Wnt/β-catenin signaling pathway.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
15
|
28209730
|
Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
16
|
10649492
|
Sequence variants of DLC1 in colorectal and ovarian tumours.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
17
|
16533763
|
Aberrant methylation and deacetylation of deleted in liver cancer-1 gene in prostate cancer: potential clinical applications.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
18
|
9605766
|
Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
19
|
16534142
|
Localization of StarD5 cholesterol binding protein.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
20
|
26846339
|
DLC-1 is an independent prognostic marker and potential therapeutic target in hepatocellular cancer.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
21
|
12770731
|
START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
22
|
18981889
|
Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
23
|
20198346
|
Synergistic antineoplastic effect of DLC1 tumor suppressor protein and histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), on prostate and liver cancer cells: perspectives for therapeutics.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
24
|
22201613
|
Overexpression of TWIST2 correlates with poor prognosis in head and neck squamous cell carcinomas.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
25
|
14633684
|
Genetic and epigenetic alterations of DLC-1 gene in hepatocellular carcinoma.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
26
|
25608809
|
Biological function and molecular mechanism of Twist2.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
27
|
20025523
|
Enhanced generation of myeloid lineages in hematopoietic differentiation from embryonic stem cells by silencing transcriptional repressor Twist-2.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
28
|
23162637
|
Expression of deleted in liver cancer 2 in colorectal cancer and its correlation with clinicopathological parameters.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
29
|
26514520
|
Clinicopathological Significance of DLC-1 Expression in Cancer: a Meta-Analysis.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
30
|
25980009
|
Haploinsufficiency for Stard7 is associated with enhanced allergic responses in lung and skin.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
31
|
17292327
|
DLC-1, a GTPase-activating protein for Rho, is associated with cell proliferation, morphology, and migration in human hepatocellular carcinoma.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
32
|
19766077
|
Association of DLC1 gene polymorphism with susceptibility to hepatocellular carcinoma in Chinese hepatitis B virus carriers.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
33
|
23033213
|
STARD4 knockdown in HepG2 cells disrupts cholesterol trafficking associated with the plasma membrane, ER, and ERC.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
34
|
23511482
|
PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
35
|
22002576
|
Loss of DLC1 is an independent prognostic factor in patients with oral squamous cell carcinoma.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
36
|
12545165
|
DLC-1 gene inhibits human breast cancer cell growth and in vivo tumorigenicity.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
37
|
24329682
|
Inhibitory effects of deleted in liver cancer 1 gene on gallbladder cancer growth through induction of cell cycle arrest and apoptosis.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
38
|
15809452
|
TWIST2 demonstrates differential methylation in immunoglobulin variable heavy chain mutated and unmutated chronic lymphocytic leukemia.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
39
|
21217778
|
A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
40
|
20059974
|
StarD4-mediated translocation of 7-hydroperoxycholesterol to isolated mitochondria: deleterious effects and implications for steroidogenesis under oxidative stress conditions.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
41
|
25728400
|
Chromosome 1p36.22p36.21 duplications/triplication causes Setleis syndrome (focal facial dermal dysplasia type III).
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
42
|
14576202
|
Transcriptional profiling of the heart reveals chamber-specific gene expression patterns.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
43
|
15201975
|
Less frequent promoter hypermethylation of DLC-1 gene in primary breast cancers.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
44
|
18615730
|
Development of a gene-trap vector with a highly sensitive fluorescent protein reporter system for expression profiling.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
45
|
26119818
|
Recurrent Mutations in the Basic Domain of TWIST2 Cause Ablepharon Macrostomia and Barber-Say Syndromes.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
46
|
12813468
|
Transcriptional silencing of the DLC-1 tumor suppressor gene by epigenetic mechanism in gastric cancer cells.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
47
|
23908159
|
Promoter hypermethylation along with LOH, but not mutation, contributes to inactivation of DLC-1 in nasopharyngeal carcinoma.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
48
|
21455586
|
Ursodeoxycholic acid-induced inhibition of DLC1 protein degradation leads to suppression of hepatocellular carcinoma cell growth.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
49
|
24338004
|
GAP-independent functions of DLC1 in metastasis.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|
50
|
26239822
|
Low expression of DLC1 is predictive of poor therapeutic efficiency of fluoropyrimidine and oxaliplatin as adjuvant chemotherapy in gastric cancer.
|
Pubmed
|
1.833E-4
|
5.587E-4
|
3.726E-3
|
8.101E-2
|
1
|
1
|