Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc79_18, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 40 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019888 protein phosphatase regulator activity 2.891E-20 1.157E-18 4.948E-18 1.157E-18 10 76
2 GO:0019208 phosphatase regulator activity 1.361E-19 2.722E-18 1.164E-17 5.443E-18 10 88
3 GO:0004722 protein serine/threonine phosphatase activity 4.568E-9 6.091E-8 2.606E-7 1.827E-7 5 68
4 GO:0004721 phosphoprotein phosphatase activity 8.411E-7 8.411E-6 3.599E-5 3.364E-5 5 192
5 GO:0036033 mediator complex binding 5.267E-6 3.698E-5 1.582E-4 2.107E-4 2 4
6 GO:0016791 phosphatase activity 5.547E-6 3.698E-5 1.582E-4 2.219E-4 5 282
7 GO:0042578 phosphoric ester hydrolase activity 4.197E-5 2.398E-4 1.026E-3 1.679E-3 5 429
8 GO:0051721 protein phosphatase 2A binding 5.131E-4 2.565E-3 1.098E-2 2.052E-2 2 35
9 GO:0008160 protein tyrosine phosphatase activator activity 1.928E-3 8.570E-3 3.667E-2
7.713E-2
 1 2
10 GO:0003823 antigen binding 5.866E-3 2.346E-2
1.004E-1
2.346E-1
 2 120
11 GO:0072542 protein phosphatase activator activity 7.692E-3 2.707E-2
1.158E-1
3.077E-1
 1 8
12 GO:0019903 protein phosphatase binding 8.122E-3 2.707E-2
1.158E-1
3.249E-1
 2 142
13 GO:1990405 protein antigen binding 9.606E-3 2.956E-2
1.265E-1
3.843E-1
 1 10
14 GO:0019211 phosphatase activator activity 1.056E-2 3.018E-2
1.291E-1
4.225E-1
 1 11
15 GO:0048156 tau protein binding 1.342E-2 3.195E-2
1.367E-1
5.370E-1
 1 14
16 GO:0019902 phosphatase binding 1.375E-2 3.195E-2
1.367E-1
5.501E-1
 2 187
17 GO:0050811 GABA receptor binding 1.438E-2 3.195E-2
1.367E-1
5.751E-1
 1 15
18 GO:0043422 protein kinase B binding 1.438E-2 3.195E-2
1.367E-1
5.751E-1
 1 15
19 GO:0008022 protein C-terminus binding 1.934E-2 4.072E-2
1.742E-1
7.736E-1
 2 224
Show 14 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 382 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043666 regulation of phosphoprotein phosphatase activity 1.719E-23 6.565E-21 4.283E-20 6.565E-21 11 67
2 GO:0010921 regulation of phosphatase activity 6.910E-20 1.320E-17 8.611E-17 2.640E-17 11 137
3 GO:0035304 regulation of protein dephosphorylation 4.309E-19 5.486E-17 3.579E-16 1.646E-16 11 161
4 GO:0035303 regulation of dephosphorylation 6.513E-19 6.220E-17 4.058E-16 2.488E-16 11 167
5 GO:0006470 protein dephosphorylation 2.192E-17 1.674E-15 1.092E-14 8.372E-15 12 344
6 GO:0016311 dephosphorylation 4.880E-16 3.107E-14 2.027E-13 1.864E-13 12 445
7 GO:0007062 sister chromatid cohesion 1.550E-9 8.460E-8 5.519E-7 5.922E-7 6 127
8 GO:0000819 sister chromatid segregation 4.785E-8 2.285E-6 1.491E-5 1.828E-5 6 225
9 GO:0051321 meiotic cell cycle 6.514E-8 2.765E-6 1.804E-5 2.488E-5 6 237
10 GO:0098813 nuclear chromosome segregation 1.860E-7 7.104E-6 4.635E-5 7.104E-5 6 283
11 GO:0007059 chromosome segregation 4.839E-7 1.681E-5 1.096E-4 1.849E-4 6 333
12 GO:1903046 meiotic cell cycle process 9.171E-7 2.920E-5 1.905E-4 3.503E-4 5 195
13 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway 2.646E-6 7.774E-5 5.072E-4 1.011E-3 2 3
14 GO:0032876 negative regulation of DNA endoreduplication 8.808E-6 2.326E-4 1.517E-3 3.365E-3 2 5
15 GO:0031952 regulation of protein autophosphorylation 9.133E-6 2.326E-4 1.517E-3 3.489E-3 3 43
16 GO:0007051 spindle organization 1.075E-5 2.566E-4 1.674E-3 4.105E-3 4 148
17 GO:0035307 positive regulation of protein dephosphorylation 1.276E-5 2.868E-4 1.871E-3 4.875E-3 3 48
18 GO:0035306 positive regulation of dephosphorylation 1.359E-5 2.883E-4 1.881E-3 5.190E-3 3 49
19 GO:0006275 regulation of DNA replication 1.943E-5 3.907E-4 2.549E-3 7.424E-3 4 172
20 GO:0032875 regulation of DNA endoreduplication 2.462E-5 4.703E-4 3.068E-3 9.405E-3 2 8
21 GO:0042023 DNA endoreduplication 3.164E-5 5.755E-4 3.755E-3 1.209E-2 2 9
22 GO:0007084 mitotic nuclear envelope reassembly 3.952E-5 6.863E-4 4.477E-3 1.510E-2 2 10
23 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway 4.828E-5 8.019E-4 5.231E-3 1.844E-2 2 11
24 GO:0042532 negative regulation of tyrosine phosphorylation of STAT protein 5.790E-5 9.216E-4 6.013E-3 2.212E-2 2 12
25 GO:0010948 negative regulation of cell cycle process 7.141E-5 1.091E-3 7.119E-3 2.728E-2 4 240
26 GO:0045786 negative regulation of cell cycle 7.519E-5 1.105E-3 7.207E-3 2.872E-2 5 484
27 GO:0007052 mitotic spindle organization 9.926E-5 1.384E-3 9.026E-3 3.792E-2 3 95
28 GO:2000104 negative regulation of DNA-dependent DNA replication 1.050E-4 1.384E-3 9.026E-3 4.012E-2 2 16
29 GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand 1.050E-4 1.384E-3 9.026E-3 4.012E-2 2 16
30 GO:0031468 nuclear envelope reassembly 1.190E-4 1.466E-3 9.565E-3 4.545E-2 2 17
31 GO:0032516 positive regulation of phosphoprotein phosphatase activity 1.190E-4 1.466E-3 9.565E-3 4.545E-2 2 17
32 GO:0007064 mitotic sister chromatid cohesion 1.659E-4 1.981E-3 1.292E-2
6.338E-2
 2 20
33 GO:0048011 neurotrophin TRK receptor signaling pathway 2.829E-4 3.182E-3 2.076E-2
1.080E-1
 2 26
34 GO:0000070 mitotic sister chromatid segregation 2.869E-4 3.182E-3 2.076E-2
1.096E-1
 3 136
35 GO:0006260 DNA replication 2.916E-4 3.182E-3 2.076E-2
1.114E-1
 4 346
36 GO:0016925 protein sumoylation 3.124E-4 3.315E-3 2.162E-2
1.193E-1
 3 140
37 GO:0001556 oocyte maturation 3.286E-4 3.393E-3 2.213E-2
1.255E-1
 2 28
38 GO:0000188 inactivation of MAPK activity 3.527E-4 3.546E-3 2.313E-2
1.347E-1
 2 29
39 GO:0051052 regulation of DNA metabolic process 3.686E-4 3.607E-3 2.353E-2
1.408E-1
 4 368
40 GO:0010922 positive regulation of phosphatase activity 3.777E-4 3.607E-3 2.353E-2
1.443E-1
 2 30
41 GO:0038179 neurotrophin signaling pathway 4.860E-4 4.420E-3 2.884E-2
1.857E-1
 2 34
42 GO:0044786 cell cycle DNA replication 4.860E-4 4.420E-3 2.884E-2
1.857E-1
 2 34
43 GO:0035825 homologous recombination 8.523E-4 7.122E-3 4.646E-2
3.256E-1
 2 45
44 GO:0007131 reciprocal meiotic recombination 8.523E-4 7.122E-3 4.646E-2
3.256E-1
 2 45
45 GO:0090329 regulation of DNA-dependent DNA replication 8.523E-4 7.122E-3 4.646E-2
3.256E-1
 2 45
46 GO:0000226 microtubule cytoskeleton organization 8.818E-4 7.122E-3 4.646E-2
3.369E-1
 4 464
47 GO:1903538 regulation of meiotic cell cycle process involved in oocyte maturation 9.665E-4 7.122E-3 4.646E-2
3.692E-1
 1 1
48 GO:1903537 meiotic cell cycle process involved in oocyte maturation 9.665E-4 7.122E-3 4.646E-2
3.692E-1
 1 1
49 GO:0051232 meiotic spindle elongation 9.665E-4 7.122E-3 4.646E-2
3.692E-1
 1 1
50 GO:0046426 negative regulation of JAK-STAT cascade 9.694E-4 7.122E-3 4.646E-2
3.703E-1
 2 48
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 54 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000159 protein phosphatase type 2A complex 1.768E-30 9.546E-29 4.368E-28 9.546E-29 11 20
2 GO:0008287 protein serine/threonine phosphatase complex 3.892E-25 7.006E-24 3.205E-23 2.102E-23 11 50
3 GO:1903293 phosphatase complex 3.892E-25 7.006E-24 3.205E-23 2.102E-23 11 50
4 GO:0000775 chromosome, centromeric region 2.834E-14 3.826E-13 1.751E-12 1.530E-12 9 185
5 GO:0098687 chromosomal region 7.713E-12 8.330E-11 3.811E-10 4.165E-10 9 344
6 GO:0030893 meiotic cohesin complex 1.944E-11 1.750E-10 8.007E-10 1.050E-9 4 7
7 GO:0008278 cohesin complex 2.742E-10 2.115E-9 9.678E-9 1.481E-8 4 12
8 GO:0000798 nuclear cohesin complex 1.412E-8 8.470E-8 3.875E-7 7.623E-7 3 6
9 GO:0034991 nuclear meiotic cohesin complex 1.412E-8 8.470E-8 3.875E-7 7.623E-7 3 6
10 GO:0000794 condensed nuclear chromosome 1.826E-6 9.858E-6 4.511E-5 9.858E-5 4 97
11 GO:0000922 spindle pole 6.426E-6 3.155E-5 1.443E-4 3.470E-4 4 133
12 GO:0000793 condensed chromosome 3.739E-5 1.683E-4 7.698E-4 2.019E-3 4 208
13 GO:0000800 lateral element 7.613E-5 3.162E-4 1.447E-3 4.111E-3 2 14
14 GO:0005819 spindle 1.711E-4 6.598E-4 3.019E-3 9.237E-3 4 308
15 GO:0000795 synaptonemal complex 6.113E-4 2.201E-3 1.007E-2 3.301E-2 2 39
16 GO:0000777 condensed chromosome kinetochore 3.570E-3 1.205E-2
5.513E-2
1.928E-1
 2 95
17 GO:0000779 condensed chromosome, centromeric region 4.342E-3 1.379E-2
6.310E-2
2.344E-1
 2 105
18 GO:0000776 kinetochore 6.000E-3 1.800E-2
8.236E-2
3.240E-1
 2 124
19 GO:0000778 condensed nuclear chromosome kinetochore 9.406E-3 2.673E-2
1.223E-1
5.079E-1
 1 10
20 GO:0000785 chromatin 1.016E-2 2.744E-2
1.256E-1
5.489E-1
 3 487
21 GO:0001673 male germ cell nucleus 1.966E-2 4.824E-2
2.207E-1
1.000E0
 1 21
22 GO:0000780 condensed nuclear chromosome, centromeric region 1.966E-2 4.824E-2
2.207E-1
1.000E0
 1 21
Show 17 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 435 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0200054 Foot monodactyly 4.022E-8 1.334E-5 8.874E-5 1.750E-5 3 6
2 HP:0000194 Open mouth 6.132E-8 1.334E-5 8.874E-5 2.668E-5 5 95
3 HP:0004523 Long eyebrows 1.125E-7 1.631E-5 1.085E-4 4.893E-5 3 8
4 HP:0010300 Abnormally low-pitched voice 2.407E-7 2.618E-5 1.742E-4 1.047E-4 3 10
5 HP:0000667 Phthisis bulbi 4.407E-7 3.717E-5 2.473E-4 1.917E-4 3 12
6 HP:0001849 Foot oligodactyly 7.283E-7 3.717E-5 2.473E-4 3.168E-4 3 14
7 HP:0007665 Curly eyelashes 9.098E-7 3.717E-5 2.473E-4 3.958E-4 3 15
8 HP:0100580 Barrett esophagus 1.119E-6 3.717E-5 2.473E-4 4.868E-4 3 16
9 HP:0009829 Phocomelia 1.119E-6 3.717E-5 2.473E-4 4.868E-4 3 16
10 HP:0000289 Broad philtrum 1.119E-6 3.717E-5 2.473E-4 4.868E-4 3 16
11 HP:0009937 Facial hirsutism 1.119E-6 3.717E-5 2.473E-4 4.868E-4 3 16
12 HP:0010034 Short 1st metacarpal 1.119E-6 3.717E-5 2.473E-4 4.868E-4 3 16
13 HP:0010026 Aplasia/Hypoplasia of the 1st metacarpal 1.119E-6 3.717E-5 2.473E-4 4.868E-4 3 16
14 HP:0000965 Cutis marmorata 1.196E-6 3.717E-5 2.473E-4 5.204E-4 4 66
15 HP:0009889 Localized hirsutism 1.358E-6 3.886E-5 2.586E-4 5.907E-4 3 17
16 HP:0011338 Abnormality of mouth shape 1.445E-6 3.886E-5 2.586E-4 6.286E-4 5 178
17 HP:0000341 Narrow forehead 1.519E-6 3.886E-5 2.586E-4 6.606E-4 4 70
18 HP:0010009 Abnormality of the 1st metacarpal 1.629E-6 3.936E-5 2.619E-4 7.084E-4 3 18
19 HP:0002021 Pyloric stenosis 2.606E-6 5.488E-5 3.651E-4 1.134E-3 4 80
20 HP:0010241 Short proximal phalanx of finger 2.649E-6 5.488E-5 3.651E-4 1.152E-3 3 21
21 HP:0009851 Aplasia/Hypoplasia of the proximal phalanges of the hand 2.649E-6 5.488E-5 3.651E-4 1.152E-3 3 21
22 HP:0004400 Abnormality of the pylorus 2.879E-6 5.693E-5 3.788E-4 1.252E-3 4 82
23 HP:0000621 Entropion 3.066E-6 5.798E-5 3.858E-4 1.334E-3 3 22
24 HP:0000207 Triangular mouth 4.024E-6 7.293E-5 4.853E-4 1.750E-3 3 24
25 HP:0002580 Volvulus 5.162E-6 8.317E-5 5.534E-4 2.246E-3 3 26
26 HP:0011951 Aspiration pneumonia 5.162E-6 8.317E-5 5.534E-4 2.246E-3 3 26
27 HP:0009660 Short phalanx of the thumb 5.162E-6 8.317E-5 5.534E-4 2.246E-3 3 26
28 HP:0012165 Oligodactyly 5.804E-6 8.706E-5 5.793E-4 2.525E-3 3 27
29 HP:0009834 Abnormal proximal phalanx morphology of the hand 5.804E-6 8.706E-5 5.793E-4 2.525E-3 3 27
30 HP:0002557 Hypoplastic nipples 6.496E-6 9.116E-5 6.065E-4 2.826E-3 3 28
31 HP:0000059 Hypoplastic labia majora 6.496E-6 9.116E-5 6.065E-4 2.826E-3 3 28
32 HP:0009658 Aplasia/Hypoplasia of the phalanges of the thumb 7.241E-6 9.844E-5 6.550E-4 3.150E-3 3 29
33 HP:0008850 Severe postnatal growth retardation 8.041E-6 1.060E-4 7.052E-4 3.498E-3 3 30
34 HP:0100751 Esophageal neoplasm 1.078E-5 1.380E-4 9.181E-4 4.691E-3 3 33
35 HP:0000902 Rib fusion 1.182E-5 1.428E-4 9.504E-4 5.142E-3 3 34
36 HP:0012881 Abnormality of the labia majora 1.182E-5 1.428E-4 9.504E-4 5.142E-3 3 34
37 HP:0012288 Neoplasm of head and neck 1.292E-5 1.519E-4 1.011E-3 5.621E-3 3 35
38 HP:0010880 Increased nuchal translucency 1.409E-5 1.580E-4 1.051E-3 6.128E-3 3 36
39 HP:0000954 Single transverse palmar crease 1.416E-5 1.580E-4 1.051E-3 6.160E-3 4 122
40 HP:0009623 Proximal placement of thumb 1.532E-5 1.666E-4 1.109E-3 6.664E-3 3 37
41 HP:0009926 Epiphora 1.800E-5 1.909E-4 1.270E-3 7.828E-3 3 39
42 HP:0009603 Deviation of the thumb 1.944E-5 1.967E-4 1.309E-3 8.457E-3 3 40
43 HP:0000066 Labial hypoplasia 1.944E-5 1.967E-4 1.309E-3 8.457E-3 3 40
44 HP:0006709 Aplasia/Hypoplasia of the nipples 2.096E-5 2.073E-4 1.379E-3 9.119E-3 3 41
45 HP:0008897 Postnatal growth retardation 2.424E-5 2.316E-4 1.541E-3 1.054E-2 3 43
46 HP:0011361 Congenital abnormal hair pattern 2.449E-5 2.316E-4 1.541E-3 1.065E-2 4 140
47 HP:0000181 Macrostomia 2.664E-5 2.414E-4 1.606E-3 1.159E-2 4 143
48 HP:0000154 Wide mouth 2.664E-5 2.414E-4 1.606E-3 1.159E-2 4 143
49 HP:0002002 Deep philtrum 2.783E-5 2.449E-4 1.629E-3 1.211E-2 3 45
50 HP:0010490 Abnormality of the palmar creases 2.814E-5 2.449E-4 1.629E-3 1.224E-2 4 145
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 13 input genes in category / 224 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 18 input genes in category / 54 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01603 B56 Pfam 4.457E-16 1.203E-14 5.506E-14 2.407E-14 5 5
2 IPR002554 PP2A B56 InterPro 4.457E-16 1.203E-14 5.506E-14 2.407E-14 5 5
3 IPR016024 ARM-type fold InterPro 4.049E-10 7.288E-9 3.335E-8 2.186E-8 8 340
4 IPR011989 ARM-like InterPro 1.391E-7 1.877E-6 8.589E-6 7.509E-6 6 271
5 IPR031090 PP2A A meta InterPro 8.718E-7 9.416E-6 4.308E-5 4.708E-5 2 2
6 1.25.10.10 - Gene3D 1.687E-6 1.176E-5 5.382E-5 9.112E-5 5 222
7 PF04824 Rad21 Rec8 Pfam 2.614E-6 1.176E-5 5.382E-5 1.412E-4 2 3
8 PF04825 Rad21 Rec8 N Pfam 2.614E-6 1.176E-5 5.382E-5 1.412E-4 2 3
9 1.10.10.580 - Gene3D 2.614E-6 1.176E-5 5.382E-5 1.412E-4 2 3
10 IPR023093 Rad21/Rec8 C InterPro 2.614E-6 1.176E-5 5.382E-5 1.412E-4 2 3
11 IPR006909 Rad21/Rec8 C eu InterPro 2.614E-6 1.176E-5 5.382E-5 1.412E-4 2 3
12 IPR006910 Rad21 Rec8 N InterPro 2.614E-6 1.176E-5 5.382E-5 1.412E-4 2 3
13 IPR024704 SMC InterPro 8.704E-6 3.615E-5 1.654E-4 4.700E-4 2 5
14 SM00968 SMC hinge SMART 1.305E-5 4.404E-5 2.015E-4 7.046E-4 2 6
15 IPR010935 SMC hinge InterPro 1.305E-5 4.404E-5 2.015E-4 7.046E-4 2 6
16 PF06470 SMC hinge Pfam 1.305E-5 4.404E-5 2.015E-4 7.046E-4 2 6
17 PF02463 SMC N Pfam 2.433E-5 7.298E-5 3.339E-4 1.314E-3 2 8
18 IPR003395 RecF/RecN/SMC N InterPro 2.433E-5 7.298E-5 3.339E-4 1.314E-3 2 8
19 SM00156 PP2Ac SMART 6.758E-5 1.738E-4 7.951E-4 3.649E-3 2 13
20 IPR006186 Ser/Thr-sp prot-phosphatase InterPro 6.758E-5 1.738E-4 7.951E-4 3.649E-3 2 13
21 PS00125 SER THR PHOSPHATASE PROSITE 6.758E-5 1.738E-4 7.951E-4 3.649E-3 2 13
22 IPR021133 HEAT type 2 InterPro 1.176E-4 2.886E-4 1.320E-3 6.348E-3 2 17
23 PF00149 Metallophos Pfam 3.247E-4 7.306E-4 3.343E-3 1.753E-2 2 28
24 IPR004843 Calcineurin-like PHP ApaH InterPro 3.247E-4 7.306E-4 3.343E-3 1.753E-2 2 28
25 3.60.21.10 - Gene3D 3.733E-4 7.752E-4 3.547E-3 2.016E-2 2 30
26 IPR029052 Metallo-depent PP-like InterPro 3.733E-4 7.752E-4 3.547E-3 2.016E-2 2 30
27 PF02985 HEAT Pfam 9.580E-4 1.674E-3 7.657E-3
5.173E-2
 2 48
28 IPR029683 SMC1A metazoan InterPro 9.608E-4 1.674E-3 7.657E-3
5.188E-2
 1 1
29 IPR004327 Phstyr phstse ac InterPro 9.608E-4 1.674E-3 7.657E-3
5.188E-2
 1 1
30 IPR029685 SMC3 InterPro 9.608E-4 1.674E-3 7.657E-3
5.188E-2
 1 1
31 PF03095 PTPA Pfam 9.608E-4 1.674E-3 7.657E-3
5.188E-2
 1 1
32 IPR000357 HEAT InterPro 1.396E-3 2.356E-3 1.078E-2
7.538E-2
 2 58
33 PS50077 HEAT REPEAT PROSITE 2.026E-3 3.315E-3 1.517E-2
1.094E-1
 2 70
34 PF13499 EF-hand 7 Pfam 2.969E-3 4.710E-3 2.155E-2
1.603E-1
 2 85
35 IPR013020 DNA helicase DNA-repair Rad3 InterPro 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
36 PF13307 Helicase C 2 Pfam 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
37 SM00491 HELICc2 SMART 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
38 SM00488 DEXDc2 SMART 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
39 PS51193 HELICASE ATP BIND 2 PROSITE 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
40 IPR014013 Helic SF1/SF2 ATP-bd DinG/Rad3 InterPro 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
41 IPR006555 ATP-dep Helicase C InterPro 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
42 PF06733 DEAD 2 Pfam 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
43 IPR010614 DEAD 2 InterPro 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
44 IPR006554 Helicase-like DEXD c2 InterPro 3.838E-3 4.710E-3 2.155E-2
2.072E-1
 1 4
45 IPR018247 EF Hand 1 Ca BS InterPro 1.203E-2 1.444E-2
6.606E-2
6.497E-1
 2 175
46 PS00018 EF HAND 1 PROSITE 1.610E-2 1.890E-2
8.646E-2
8.692E-1
 2 204
47 PS50222 EF HAND 2 PROSITE 2.034E-2 2.307E-2
1.055E-1
1.000E0
 2 231
48 IPR002048 EF hand dom InterPro 2.050E-2 2.307E-2
1.055E-1
1.000E0
 2 232
49 IPR011991 WHTH DNA-bd dom InterPro 2.236E-2 2.464E-2
1.127E-1
1.000E0
 2 243
50 1.10.238.10 - Gene3D 2.554E-2 2.758E-2
1.262E-1
1.000E0
 2 261
Show 45 more annotations

7: Pathway [Display Chart] 17 input genes in category / 211 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M1940 Regulation And Function Of ChREBP in Liver MSigDB C2 BIOCARTA (v6.0) 2.350E-27 4.958E-25 2.941E-24 4.958E-25 12 42
2 1268912 AXIN missense mutants destabilize the destruction complex BioSystems: REACTOME 2.457E-24 7.407E-23 4.394E-22 5.185E-22 9 14
3 1268907 truncated APC mutants destabilize the destruction complex BioSystems: REACTOME 2.457E-24 7.407E-23 4.394E-22 5.185E-22 9 14
4 1268913 AMER1 mutants destabilize the destruction complex BioSystems: REACTOME 2.457E-24 7.407E-23 4.394E-22 5.185E-22 9 14
5 1268915 Truncations of AMER1 destabilize the destruction complex BioSystems: REACTOME 2.457E-24 7.407E-23 4.394E-22 5.185E-22 9 14
6 1268910 AXIN mutants destabilize the destruction complex, activating WNT signaling BioSystems: REACTOME 2.457E-24 7.407E-23 4.394E-22 5.185E-22 9 14
7 1268909 APC truncation mutants have impaired AXIN binding BioSystems: REACTOME 2.457E-24 7.407E-23 4.394E-22 5.185E-22 9 14
8 1268917 S45 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 6.140E-24 9.966E-23 5.911E-22 1.296E-21 9 15
9 1268919 S37 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 6.140E-24 9.966E-23 5.911E-22 1.296E-21 9 15
10 1268920 S33 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 6.140E-24 9.966E-23 5.911E-22 1.296E-21 9 15
11 1268918 T41 mutants of beta-catenin aren't phosphorylated BioSystems: REACTOME 6.140E-24 9.966E-23 5.911E-22 1.296E-21 9 15
12 1268921 Misspliced GSK3beta mutants stabilize beta-catenin BioSystems: REACTOME 6.140E-24 9.966E-23 5.911E-22 1.296E-21 9 15
13 1268916 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex BioSystems: REACTOME 6.140E-24 9.966E-23 5.911E-22 1.296E-21 9 15
14 1269597 Beta-catenin phosphorylation cascade BioSystems: REACTOME 2.979E-23 4.190E-22 2.485E-21 6.285E-21 9 17
15 1269348 Platelet sensitization by LDL BioSystems: REACTOME 2.979E-23 4.190E-22 2.485E-21 6.285E-21 9 17
16 1269821 Resolution of Sister Chromatid Cohesion BioSystems: REACTOME 3.176E-22 4.188E-21 2.484E-20 6.702E-20 12 103
17 1269181 CTLA4 inhibitory signaling BioSystems: REACTOME 6.078E-22 7.543E-21 4.474E-20 1.282E-19 9 22
18 1269820 Mitotic Prometaphase BioSystems: REACTOME 8.167E-22 9.573E-21 5.678E-20 1.723E-19 12 111
19 1269286 RAF activation BioSystems: REACTOME 2.492E-21 2.767E-20 1.641E-19 5.258E-19 9 25
20 126909 Oocyte meiosis BioSystems: KEGG 3.282E-21 3.462E-20 2.054E-19 6.924E-19 12 124
21 193328 mRNA surveillance pathway BioSystems: KEGG 2.035E-20 2.044E-19 1.213E-18 4.293E-18 11 91
22 1269601 Disassembly of the destruction complex and recruitment of AXIN to the membrane BioSystems: REACTOME 3.407E-20 3.268E-19 1.938E-18 7.189E-18 9 32
23 1268906 Signaling by WNT in cancer BioSystems: REACTOME 8.562E-20 7.855E-19 4.659E-18 1.807E-17 9 35
24 1269826 Separation of Sister Chromatids BioSystems: REACTOME 1.656E-19 1.456E-18 8.635E-18 3.494E-17 12 170
25 1269288 Negative regulation of MAPK pathway BioSystems: REACTOME 3.306E-19 2.790E-18 1.655E-17 6.976E-17 9 40
26 1269825 Mitotic Anaphase BioSystems: REACTOME 3.587E-19 2.911E-18 1.727E-17 7.569E-17 12 181
27 1269823 Mitotic Metaphase and Anaphase BioSystems: REACTOME 3.839E-19 3.000E-18 1.779E-17 8.100E-17 12 182
28 1144995 Sphingolipid signaling pathway BioSystems: KEGG 4.064E-19 3.063E-18 1.817E-17 8.576E-17 11 118
29 989139 AMPK signaling pathway BioSystems: KEGG 5.416E-19 3.941E-18 2.337E-17 1.143E-16 11 121
30 469199 Dopaminergic synapse BioSystems: KEGG 1.228E-18 8.636E-18 5.123E-17 2.591E-16 11 130
31 908257 Adrenergic signaling in cardiomyocytes BioSystems: KEGG 3.926E-18 2.672E-17 1.585E-16 8.283E-16 11 144
32 1269177 Costimulation by the CD28 family BioSystems: REACTOME 1.152E-16 7.593E-16 4.504E-15 2.430E-14 9 73
33 1269810 M Phase BioSystems: REACTOME 2.648E-16 1.693E-15 1.004E-14 5.587E-14 12 311
34 1269596 Degradation of beta-catenin by the destruction complex BioSystems: REACTOME 4.850E-16 3.010E-15 1.785E-14 1.023E-13 9 85
35 1383020 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling BioSystems: REACTOME 6.035E-16 3.638E-15 2.158E-14 1.273E-13 9 87
36 1269341 Platelet homeostasis BioSystems: REACTOME 9.200E-16 5.392E-15 3.198E-14 1.941E-13 9 91
37 1269191 Negative regulation of the PI3K/AKT network BioSystems: REACTOME 1.246E-15 7.108E-15 4.216E-14 2.630E-13 9 94
38 P00021 FGF signaling pathway PantherDB 2.671E-15 1.483E-14 8.798E-14 5.637E-13 9 102
39 1269519 RHO GTPases Activate Formins BioSystems: REACTOME 9.549E-15 5.166E-14 3.064E-13 2.015E-12 9 117
40 1269188 PIP3 activates AKT signaling BioSystems: REACTOME 1.760E-14 9.282E-14 5.506E-13 3.713E-12 9 125
41 1269473 PI3K/AKT activation BioSystems: REACTOME 2.190E-14 1.100E-13 6.526E-13 4.621E-12 9 128
42 1269384 GAB1 signalosome BioSystems: REACTOME 2.190E-14 1.100E-13 6.526E-13 4.621E-12 9 128
43 1269302 Role of LAT2/NTAL/LAB on calcium mobilization BioSystems: REACTOME 4.094E-14 2.009E-13 1.192E-12 8.638E-12 9 137
44 1270113 PP2A-mediated dephosphorylation of key metabolic factors BioSystems: REACTOME 5.209E-14 2.498E-13 1.482E-12 1.099E-11 5 7
45 692234 PI3K-Akt signaling pathway BioSystems: KEGG 6.124E-14 2.871E-13 1.703E-12 1.292E-11 11 342
46 1269185 Downstream signaling events of B Cell Receptor (BCR) BioSystems: REACTOME 1.237E-12 5.675E-12 3.366E-11 2.610E-10 9 199
47 1269216 ERKs are inactivated BioSystems: REACTOME 3.177E-12 1.397E-11 8.284E-11 6.703E-10 5 13
48 1269775 Inhibition of replication initiation of damaged DNA by RB1/E2F1 BioSystems: REACTOME 3.177E-12 1.397E-11 8.284E-11 6.703E-10 5 13
49 1269183 Signaling by the B Cell Receptor (BCR) BioSystems: REACTOME 5.783E-12 2.490E-11 1.477E-10 1.220E-9 9 236
50 1269599 TCF dependent signaling in response to WNT BioSystems: REACTOME 7.252E-12 3.060E-11 1.815E-10 1.530E-9 9 242
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 1456 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21072166 PP2A1 binding, cell transducing and apoptotic properties of Vpr(77-92): a new functional domain of HIV-1 Vpr proteins. Pubmed 3.932E-37 5.726E-34 4.501E-33 5.726E-34 11 13
2 9013886 Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr. Pubmed 1.835E-36 8.905E-34 7.000E-33 2.672E-33 11 14
3 9400615 Increasing the ratio of PP2A core enzyme to holoenzyme inhibits Tat-stimulated HIV-1 transcription and virus production. Pubmed 1.835E-36 8.905E-34 7.000E-33 2.672E-33 11 14
4 21351466 [Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors]. Pubmed 6.235E-35 1.816E-32 1.427E-31 9.079E-32 11 17
5 17266553 Regulation of HIV-1 transcription by protein phosphatase 1. Pubmed 6.235E-35 1.816E-32 1.427E-31 9.079E-32 11 17
6 23287597 Molecular mechanisms involved in HIV-1-Tat mediated inhibition of telomerase activity in human CD4(+) T lymphocytes. Pubmed 1.603E-34 3.890E-32 3.058E-31 2.334E-31 11 18
7 11531413 HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving regulatory and catalytic subunits of PP2A and acting on both Wee1 and Cdc25. Pubmed 6.558E-32 1.364E-29 1.072E-28 9.548E-29 11 27
8 18782753 A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. Pubmed 6.689E-29 1.217E-26 9.570E-26 9.739E-26 11 46
9 16541025 Shugoshin collaborates with protein phosphatase 2A to protect cohesin. Pubmed 9.414E-27 1.523E-24 1.197E-23 1.371E-23 9 19
10 16541024 Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I. Pubmed 1.929E-25 2.808E-23 2.207E-22 2.808E-22 8 12
11 18971272 Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29. Pubmed 5.013E-25 6.635E-23 5.216E-22 7.299E-22 8 13
12 7592815 Identification of a new family of protein phosphatase 2A regulatory subunits. Pubmed 1.354E-24 1.516E-22 1.192E-21 1.971E-21 7 7
13 8703017 The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm. Pubmed 1.354E-24 1.516E-22 1.192E-21 1.971E-21 7 7
14 15380617 Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit. Pubmed 1.071E-21 1.114E-19 8.754E-19 1.559E-18 7 12
15 16048649 Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription. Pubmed 4.638E-21 4.502E-19 3.539E-18 6.753E-18 7 14
16 12370081 Characterization of the Aalpha and Abeta subunit isoforms of protein phosphatase 2A: differences in expression, subunit interaction, and evolution. Pubmed 1.206E-19 1.097E-17 8.624E-17 1.755E-16 6 8
17 17540176 The tumor suppressor PP2A Abeta regulates the RalA GTPase. Pubmed 4.528E-18 3.878E-16 3.049E-15 6.593E-15 7 32
18 8694763 The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. Pubmed 1.265E-17 9.698E-16 7.623E-15 1.843E-14 5 5
19 8812429 Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. Pubmed 1.265E-17 9.698E-16 7.623E-15 1.843E-14 5 5
20 9847399 Binding specificity of protein phosphatase 2A core enzyme for regulatory B subunits and T antigens. Pubmed 7.591E-17 5.526E-15 4.344E-14 1.105E-13 5 6
21 19156129 An integrated workflow for charting the human interaction proteome: insights into the PP2A system. Pubmed 1.242E-16 8.612E-15 6.770E-14 1.808E-13 8 107
22 11007961 Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. Pubmed 7.081E-16 4.686E-14 3.684E-13 1.031E-12 5 8
23 16456541 B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. Pubmed 1.593E-15 1.008E-13 7.926E-13 2.319E-12 5 9
24 23555304 Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. Pubmed 1.393E-14 8.451E-13 6.644E-12 2.028E-11 6 39
25 11929880 Protein phosphatase 2A holoenzyme assembly: identification of contacts between B-family regulatory and scaffolding A subunits. Pubmed 3.452E-14 1.862E-12 1.463E-11 5.026E-11 4 4
26 15095873 Genomic organisation, chromosomal localisation tissue distribution and developmental regulation of the PR61/B' regulatory subunits of protein phosphatase 2A in mice. Pubmed 3.452E-14 1.862E-12 1.463E-11 5.026E-11 4 4
27 28174209 Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. Pubmed 3.452E-14 1.862E-12 1.463E-11 5.026E-11 4 4
28 18596935 Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice. Pubmed 1.725E-13 8.374E-12 6.583E-11 2.512E-10 4 5
29 11591705 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. Pubmed 1.725E-13 8.374E-12 6.583E-11 2.512E-10 4 5
30 10629059 PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. Pubmed 1.725E-13 8.374E-12 6.583E-11 2.512E-10 4 5
31 21172653 The dependence receptor UNC5H2/B triggers apoptosis via PP2A-mediated dephosphorylation of DAP kinase. Pubmed 5.175E-13 2.355E-11 1.851E-10 7.535E-10 4 6
32 19915589 The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A. Pubmed 5.175E-13 2.355E-11 1.851E-10 7.535E-10 4 6
33 10698523 GSK-3beta-dependent phosphorylation of adenomatous polyposis coli gene product can be modulated by beta-catenin and protein phosphatase 2A complexed with Axin. Pubmed 1.207E-12 5.326E-11 4.187E-10 1.758E-9 4 7
34 17245430 A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. Pubmed 2.414E-12 9.248E-11 7.270E-10 3.514E-9 4 8
35 18432318 Differential expression of the catalytic subunits for PP-1 and PP-2A and the regulatory subunits for PP-2A in mouse eye. Pubmed 2.414E-12 9.248E-11 7.270E-10 3.514E-9 4 8
36 12912990 Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A. Pubmed 2.414E-12 9.248E-11 7.270E-10 3.514E-9 4 8
37 26280018 PLK1 is a binding partner and a negative regulator of FOXO3 tumor suppressor. Pubmed 2.414E-12 9.248E-11 7.270E-10 3.514E-9 4 8
38 11956189 Cyclin G2 associates with protein phosphatase 2A catalytic and regulatory B' subunits in active complexes and induces nuclear aberrations and a G1/S phase cell cycle arrest. Pubmed 2.414E-12 9.248E-11 7.270E-10 3.514E-9 4 8
39 14645548 Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A. Pubmed 4.343E-12 1.621E-10 1.275E-9 6.324E-9 4 9
40 22422068 Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic development. Pubmed 5.466E-12 1.941E-10 1.526E-9 7.959E-9 5 37
41 26811472 Control of APC/C-dependent ubiquitin chain elongation by reversible phosphorylation. Pubmed 5.466E-12 1.941E-10 1.526E-9 7.959E-9 5 37
42 21242291 RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. Pubmed 7.236E-12 2.509E-10 1.972E-9 1.054E-8 4 10
43 12435421 Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5. Pubmed 1.705E-11 5.772E-10 4.538E-9 2.482E-8 4 12
44 16717086 PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. Pubmed 2.462E-11 8.146E-10 6.403E-9 3.584E-8 4 13
45 21514445 Protein phosphatase 2A catalytic subunit α (PP2Acα) maintains survival of committed erythroid cells in fetal liver erythropoiesis through the STAT5 pathway. Pubmed 6.260E-11 2.026E-9 1.592E-8 9.115E-8 4 16
46 17174897 Structure of the protein phosphatase 2A holoenzyme. Pubmed 8.789E-11 2.559E-9 2.012E-8 1.280E-7 3 3
47 17105772 The DNA helicase ChlR1 is required for sister chromatid cohesion in mammalian cells. Pubmed 8.789E-11 2.559E-9 2.012E-8 1.280E-7 3 3
48 10375619 Characterization of the components of the putative mammalian sister chromatid cohesion complex. Pubmed 8.789E-11 2.559E-9 2.012E-8 1.280E-7 3 3
49 8392071 Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. Pubmed 8.789E-11 2.559E-9 2.012E-8 1.280E-7 3 3
50 25972378 Mutations in the PP2A regulatory subunit B family genes PPP2R5B, PPP2R5C and PPP2R5D cause human overgrowth. Pubmed 8.789E-11 2.559E-9 2.012E-8 1.280E-7 3 3
Show 45 more annotations

9: Interaction [Display Chart] 18 input genes in category / 1126 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PPP2R1B PPP2R1B interactions 1.204E-20 1.356E-17 1.031E-16 1.356E-17 11 112
2 int:PRR14 PRR14 interactions 8.914E-20 5.019E-17 3.816E-16 1.004E-16 8 23
3 int:PPP2CA PPP2CA interactions 1.277E-17 4.794E-15 3.646E-14 1.438E-14 12 313
4 int:SGO1 SGO1 interactions 2.934E-17 8.259E-15 6.280E-14 3.304E-14 9 82
5 int:PPP2R1A PPP2R1A interactions 1.766E-16 3.695E-14 2.809E-13 1.988E-13 12 389
6 int:PPP2CB PPP2CB interactions 1.969E-16 3.695E-14 2.809E-13 2.217E-13 10 169
7 int:FAM43A FAM43A interactions 1.299E-15 2.090E-13 1.589E-12 1.463E-12 6 14
8 int:PPP2R5A PPP2R5A interactions 4.454E-15 6.270E-13 4.767E-12 5.016E-12 7 39
9 int:CCNG2 CCNG2 interactions 5.344E-15 6.686E-13 5.084E-12 6.018E-12 6 17
10 int:PPP2R5C PPP2R5C interactions 1.813E-14 2.042E-12 1.553E-11 2.042E-11 7 47
11 int:TBCCD1 TBCCD1 interactions 1.766E-12 1.808E-10 1.375E-9 1.988E-9 5 15
12 int:PPP2R3B PPP2R3B interactions 2.567E-12 2.409E-10 1.832E-9 2.890E-9 5 16
13 int:CCNG1 CCNG1 interactions 3.001E-12 2.599E-10 1.976E-9 3.379E-9 6 44
14 int:CHEK2 CHEK2 interactions 2.081E-11 1.674E-9 1.273E-8 2.343E-8 7 124
15 int:PPP2R5E PPP2R5E interactions 2.586E-11 1.941E-9 1.476E-8 2.912E-8 6 62
16 int:SMC1B SMC1B interactions 5.223E-11 3.675E-9 2.795E-8 5.881E-8 4 8
17 int:PPP2R3A PPP2R3A interactions 9.894E-11 6.553E-9 4.983E-8 1.114E-7 5 31
18 int:PPP2R5D PPP2R5D interactions 1.070E-10 6.696E-9 5.092E-8 1.205E-7 6 78
19 int:DEC1 DEC1 interactions 1.172E-10 6.945E-9 5.281E-8 1.320E-7 5 32
20 int:WNT3A WNT3A interactions 1.380E-10 7.771E-9 5.909E-8 1.554E-7 5 33
21 int:RORC RORC interactions 3.336E-10 1.789E-8 1.360E-7 3.757E-7 5 39
22 int:UNC5B UNC5B interactions 3.684E-10 1.885E-8 1.434E-7 4.148E-7 4 12
23 int:PPP2R2D PPP2R2D interactions 7.406E-10 3.626E-8 2.757E-7 8.339E-7 6 107
24 int:SERTAD4 SERTAD4 interactions 1.014E-9 4.757E-8 3.617E-7 1.142E-6 4 15
25 int:PPP2R2A PPP2R2A interactions 1.902E-9 8.567E-8 6.514E-7 2.142E-6 6 125
26 int:AXIN1 AXIN1 interactions 2.644E-9 1.145E-7 8.707E-7 2.977E-6 6 132
27 int:PTPA PTPA interactions 5.934E-9 2.386E-7 1.815E-6 6.682E-6 5 68
28 int:PPP4C PPP4C interactions 5.934E-9 2.386E-7 1.815E-6 6.682E-6 5 68
29 int:SET SET interactions 1.299E-8 5.044E-7 3.835E-6 1.463E-5 6 172
30 int:CTTNBP2 CTTNBP2 interactions 3.005E-8 1.128E-6 8.577E-6 3.384E-5 4 33
31 int:PPP4R1 PPP4R1 interactions 4.318E-8 1.568E-6 1.193E-5 4.862E-5 4 36
32 int:WFDC5 WFDC5 interactions 4.927E-8 1.734E-6 1.318E-5 5.548E-5 3 8
33 int:SIKE1 SIKE1 interactions 5.404E-8 1.844E-6 1.402E-5 6.085E-5 4 38
34 int:CTTNBP2NL CTTNBP2NL interactions 7.399E-8 2.380E-6 1.810E-5 8.332E-5 4 41
35 int:FOXD4 FOXD4 interactions 7.399E-8 2.380E-6 1.810E-5 8.332E-5 4 41
36 int:SYCP3 SYCP3 interactions 1.054E-7 3.298E-6 2.508E-5 1.187E-4 3 10
37 int:PPP2R2C PPP2R2C interactions 1.814E-7 5.522E-6 4.199E-5 2.043E-4 4 51
38 int:ZNF114 ZNF114 interactions 1.931E-7 5.671E-6 4.313E-5 2.174E-4 3 12
39 int:FGFR1OP2 FGFR1OP2 interactions 1.964E-7 5.671E-6 4.313E-5 2.212E-4 4 52
40 int:STK25 STK25 interactions 2.470E-7 6.953E-6 5.287E-5 2.781E-4 4 55
41 int:CRY1 CRY1 interactions 2.799E-7 7.687E-6 5.846E-5 3.152E-4 5 146
42 int:PDCD10 PDCD10 interactions 3.067E-7 8.164E-6 6.208E-5 3.453E-4 4 58
43 int:PPP2R5B PPP2R5B interactions 3.190E-7 8.164E-6 6.208E-5 3.592E-4 3 14
44 int:FBXL16 FBXL16 interactions 3.190E-7 8.164E-6 6.208E-5 3.592E-4 3 14
45 int:INTS1 INTS1 interactions 3.288E-7 8.227E-6 6.256E-5 3.702E-4 4 59
46 int:INTS6 INTS6 interactions 3.520E-7 8.617E-6 6.553E-5 3.964E-4 4 60
47 int:EP400 EP400 interactions 4.575E-7 1.096E-5 8.335E-5 5.152E-4 4 64
48 int:SLMAP SLMAP interactions 5.183E-7 1.191E-5 9.057E-5 5.836E-4 4 66
49 int:PPP2R2B PPP2R2B interactions 5.183E-7 1.191E-5 9.057E-5 5.836E-4 4 66
50 int:PRR14L PRR14L interactions 5.949E-7 1.313E-5 9.987E-5 6.698E-4 3 17
Show 45 more annotations

10: Cytoband [Display Chart] 18 input genes in category / 19 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q32.2-q32.3 1q32.2-q32.3 5.193E-4 9.867E-3 3.501E-2 9.867E-3 1 1
2 Xp11.22-p11.21 Xp11.22-p11.21 2.076E-3 1.972E-2
6.996E-2
 3.944E-2 1 4
3 14q11.2-q12 14q11.2-q12 4.147E-3 2.165E-2
7.682E-2
7.880E-2
 1 8
4 12p11 12p11 4.665E-3 2.165E-2
7.682E-2
8.863E-2
 1 9
5 10q25 10q25 5.698E-3 2.165E-2
7.682E-2
1.083E-1
 1 11
6 Yp11.3 Yp11.3 8.279E-3 2.291E-2
8.128E-2
1.573E-1
 1 16
7 3q13.13 3q13.13 9.309E-3 2.291E-2
8.128E-2
1.769E-1
 1 18
8 11q23.2 11q23.2 9.824E-3 2.291E-2
8.128E-2
1.866E-1
 1 19
9 11q12 11q12 1.085E-2 2.291E-2
8.128E-2
2.062E-1
 1 21
10 Xp22.33 Xp22.33 1.496E-2 2.584E-2
9.166E-2
2.842E-1
 1 29
11 8q24 8q24 1.496E-2 2.584E-2
9.166E-2
2.842E-1
 1 29
12 3q22.1 3q22.1 2.261E-2 3.413E-2
1.211E-1
4.296E-1
 1 44
13 14q23.1 14q23.1 2.413E-2 3.413E-2
1.211E-1
4.586E-1
 1 47
14 8p12 8p12 2.515E-2 3.413E-2
1.211E-1
4.778E-1
 1 49
15 9q34 9q34 2.768E-2 3.506E-2
1.244E-1
5.259E-1
 1 54
16 5q31.1 5q31.1 3.323E-2 3.946E-2
1.400E-1
6.314E-1
 1 65
17 14q32.31 14q32.31 3.574E-2 3.995E-2
1.417E-1
6.791E-1
 1 70
18 19q13.41 19q13.41 4.075E-2 4.175E-2
1.481E-1
7.742E-1
 1 80
19 6p21.1 6p21.1 4.175E-2 4.175E-2
1.481E-1
7.932E-1
 1 82
Show 14 more annotations

11: Transcription Factor Binding Site [Display Chart] 14 input genes in category / 158 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 17 input genes in category / 13 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 696 Protein phosphatase 2 regulatory subunits genenames.org 9.532E-19 1.239E-17 3.941E-17 1.239E-17 7 15
2 1060 Cohesin complex genenames.org 3.642E-11 2.367E-10 7.528E-10 4.734E-10 4 8
3 1371 STRIPAK complex genenames.org 2.503E-9 1.085E-8 3.450E-8 3.254E-8 4 20
4 1266 Protein phosphatase 2 scaffold subunits|STRIPAK complex genenames.org 8.217E-7 2.671E-6 8.493E-6 1.068E-5 2 2
5 761 Structural maintenance of chromosomes proteins|SMC5-6 protein complex genenames.org 1.721E-5 4.474E-5 1.423E-4 2.237E-4 2 7
6 693 Protein phosphatase catalytic subunits genenames.org 6.371E-5 1.380E-4 4.390E-4 8.282E-4 2 13
7 1265 Protein phosphatase 2 modulatory subunits genenames.org 4.664E-3 8.661E-3 2.754E-2
6.063E-2
 1 5
8 570 Proteoglycans|Structural maintenance of chromosomes proteins|Cohesin complex genenames.org 6.523E-3 1.060E-2 3.371E-2
8.480E-2
 1 7
9 1167 INO80 complex |DNA helicases genenames.org 1.577E-2 2.082E-2
6.620E-2
2.050E-1
 1 17
10 863 EF-hand domain containing genenames.org 1.742E-2 2.082E-2
6.620E-2
2.264E-1
 2 219
11 909 Tetratricopeptide repeat domain containing|Cyclophilin peptidylprolyl isomerases genenames.org 1.761E-2 2.082E-2
6.620E-2
2.290E-1
 1 19
12 715 MicroRNAs|Pseudoautosomal region 1 genenames.org 2.311E-2 2.504E-2
7.963E-2
3.005E-1
 1 25
13 499 DEAD-box helicases genenames.org 3.854E-2 3.854E-2
1.226E-1
5.011E-1
 1 42
Show 8 more annotations

13: Coexpression [Display Chart] 18 input genes in category / 1486 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9372 Genes involved in DNA replication, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.035E-11 1.538E-8 1.212E-7 1.538E-8 7 146
2 M15305 Genes constituting the BRCA-centered network (BCN). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.799E-6 1.337E-3 1.054E-2 2.674E-3 4 117
3 17150101-TableS1l Human Breast Troester06 436genes-up-DOX-ZR75-1 GeneSigDB 4.150E-6 2.042E-3 1.609E-2 6.167E-3 5 329
4 M2536 Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.496E-6 2.042E-3 1.609E-2 8.168E-3 3 45
5 M18811 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.580E-6 2.253E-3 1.776E-2 1.126E-2 4 168
6 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 1.046E-5 2.489E-3 1.962E-2 1.555E-2 5 398
7 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.404E-5 2.489E-3 1.962E-2 2.087E-2 5 423
8 M6010 Genes down-regulated in dendritic cells: wildtype versus I ab-/- mice. MSigDB C7: Immunologic Signatures (v6.0) 1.478E-5 2.489E-3 1.962E-2 2.197E-2 4 199
9 M7447 Genes down-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: TGF beta versus TGF beta and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 2.489E-3 1.962E-2 2.241E-2 4 200
10 M2733 Cellular proliferation, growth, apoptosis and Wnt signaling genes down-regulated in SNU638 cells (gastric cancer) by overexpression of SFRP2 [GeneID=6423] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.697E-4 2.522E-2
1.987E-1
2.522E-1
 2 25
11 15741219-Table3 Human StemCell Roth05 33genes GeneSigDB 2.975E-4 3.690E-2
2.908E-1
4.422E-1
 2 33
12 M15589 Genes up-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.953E-4 3.690E-2
2.908E-1
5.873E-1
 2 38
13 15598354-SuppTable7a Human Breast Shen04 45genes UpRegulated GeneSigDB 3.953E-4 3.690E-2
2.908E-1
5.873E-1
 2 38
14 16585155-TableS1 Human Colon Watanabe06 214genes GeneSigDB 4.188E-4 3.690E-2
2.908E-1
6.223E-1
 3 192
15 M13522 Common down-regulated transcripts in fibroblasts expressing either XP/CS or TDD mutant forms of ERCC3 [GeneID=2071], after UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.549E-4 3.690E-2
2.908E-1
6.759E-1
 4 483
16 M7369 Genes down-regulated in the activated CD4 [GeneID=920] T cells (48h): IL-12 and IL18 [GeneID=3606] versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 4.649E-4 3.690E-2
2.908E-1
6.909E-1
 3 199
17 M3563 Genes down-regulated in comparison of resting regulatory T cell (Treg) versus activated regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.690E-2
2.908E-1
7.011E-1
 3 200
18 M5019 Genes down-regulated in comparison of plasmacytoid dendritic cells from LAIV influenza vaccinee at day 7 post-vaccination vesus those from TIV influenza vaccinee at day 7. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.690E-2
2.908E-1
7.011E-1
 3 200
19 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 4.718E-4 3.690E-2
2.908E-1
7.011E-1
 3 200
Show 14 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 742 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 15 input genes in category / 173 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 18 input genes in category / 882 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 1.368E-6 6.032E-4 4.440E-3 1.206E-3 4 338
2 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 1.368E-6 6.032E-4 4.440E-3 1.206E-3 4 338
3 GTGCCAT,MIR-183:MSigDB GTGCCAT,MIR-183:MSigDB MSigDB 9.309E-6 2.737E-3 2.014E-2 8.211E-3 3 165
4 hsa-miR-220c:PITA hsa-miR-220c:PITA TOP PITA 1.755E-5 3.869E-3 2.848E-2 1.548E-2 3 204
5 hsa-miR-423-3p:Functional MTI Functional MTI miRTarbase 2.509E-5 4.060E-3 2.988E-2 2.213E-2 3 230
6 hsa-miR-4306:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.177E-5 4.060E-3 2.988E-2 2.802E-2 3 249
7 hsa-miR-4644:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.254E-5 4.060E-3 2.988E-2 2.870E-2 3 251
8 hsa-miR-183:PITA hsa-miR-183:PITA TOP PITA 3.823E-5 4.060E-3 2.988E-2 3.372E-2 3 265
9 hsa-miR-6876-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.321E-5 4.060E-3 2.988E-2 3.811E-2 2 39
10 hsa-miR-626:Non-Functional MTI Non-Functional MTI miRTarbase 4.780E-5 4.060E-3 2.988E-2 4.216E-2 2 41
11 hsa-miR-4278:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.513E-5 4.060E-3 2.988E-2 4.862E-2 2 44
12 hsa-miR-107:Functional MTI Functional MTI miRTarbase 5.524E-5 4.060E-3 2.988E-2 4.872E-2 3 300
13 hsa-miR-3138:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.297E-5 4.272E-3 3.144E-2
5.554E-2
 2 47
14 hsa-miR-371b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.327E-5 4.875E-3 3.588E-2
7.344E-2
 2 54
15 hsa-miR-132-3p:TargetScan hsa-miR-132-3p TargetScan 9.396E-5 4.875E-3 3.588E-2
8.287E-2
 3 359
16 hsa-miR-185-5p:Functional MTI Functional MTI miRTarbase 9.396E-5 4.875E-3 3.588E-2
8.287E-2
 3 359
17 hsa-miR-212-3p:TargetScan hsa-miR-212-3p TargetScan 9.396E-5 4.875E-3 3.588E-2
8.287E-2
 3 359
18 hsa-miR-183-5p.1:TargetScan hsa-miR-183-5p.1 TargetScan 1.011E-4 4.953E-3 3.645E-2
8.915E-2
 3 368
19 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 1.430E-4 6.361E-3 4.681E-2
1.261E-1
 3 414
20 hsa-miR-5586-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.442E-4 6.361E-3 4.681E-2
1.272E-1
 2 71
21 hsa-miR-5007-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.610E-4 6.627E-3 4.877E-2
1.420E-1
 2 75
22 hsa-miR-3977:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.653E-4 6.627E-3 4.877E-2
1.458E-1
 2 76
23 hsa-miR-6505-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.741E-4 6.677E-3 4.914E-2
1.536E-1
 2 78
24 hsa-miR-103a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.863E-4 6.790E-3 4.997E-2
1.644E-1
 3 453
25 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 1.925E-4 6.790E-3 4.997E-2
1.697E-1
 3 458
26 hsa-miR-4711-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.267E-4 6.967E-3
5.128E-2
1.999E-1
 2 89
27 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 2.304E-4 6.967E-3
5.128E-2
2.032E-1
 3 487
28 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 2.304E-4 6.967E-3
5.128E-2
2.032E-1
 3 487
29 hsa-miR-4425:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.318E-4 6.967E-3
5.128E-2
2.045E-1
 2 90
30 hsa-miR-92a-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.370E-4 6.967E-3
5.128E-2
2.090E-1
 2 91
31 hsa-miR-6732-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.804E-4 7.978E-3
5.872E-2
2.473E-1
 2 99
32 hsa-miR-6805-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.976E-4 8.203E-3
6.037E-2
2.625E-1
 2 102
33 hsa-miR-185-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.586E-4 9.585E-3
7.054E-2
3.163E-1
 2 112
34 hsa-miR-1291:PITA hsa-miR-1291:PITA TOP PITA 4.899E-4 1.271E-2
9.353E-2
4.321E-1
 2 131
35 hsa-miR-505-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.124E-4 1.291E-2
9.504E-2
4.520E-1
 2 134
36 hsa-miR-4756-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.433E-4 1.295E-2
9.531E-2
4.792E-1
 2 138
37 hsa-miR-525-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.433E-4 1.295E-2
9.531E-2
4.792E-1
 2 138
38 hsa-miR-520a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.670E-4 1.316E-2
9.686E-2
5.001E-1
 2 141
39 hsa-miR-510-5p:Functional MTI Functional MTI miRTarbase 6.326E-4 1.431E-2
1.053E-1
5.580E-1
 2 149
40 hsa-miR-1243:PITA hsa-miR-1243:PITA TOP PITA 6.842E-4 1.491E-2
1.097E-1
6.035E-1
 2 155
41 hsa-miR-384:PITA hsa-miR-384:PITA TOP PITA 6.930E-4 1.491E-2
1.097E-1
6.112E-1
 2 156
42 hsa-miR-6794-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.745E-4 1.510E-2
1.111E-1
6.831E-1
 2 165
43 hsa-miR-4716-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.932E-4 1.510E-2
1.111E-1
6.996E-1
 2 167
44 hsa-miR-502-3p:PITA hsa-miR-502-3p:PITA TOP PITA 8.121E-4 1.510E-2
1.111E-1
7.163E-1
 2 169
45 hsa-miR-1265:PITA hsa-miR-1265:PITA TOP PITA 8.217E-4 1.510E-2
1.111E-1
7.247E-1
 2 170
46 hsa-miR-299-5p:PITA hsa-miR-299-5p:PITA TOP PITA 8.217E-4 1.510E-2
1.111E-1
7.247E-1
 2 170
47 hsa-miR-501-3p:PITA hsa-miR-501-3p:PITA TOP PITA 8.217E-4 1.510E-2
1.111E-1
7.247E-1
 2 170
48 hsa-miR-1206:PITA hsa-miR-1206:PITA TOP PITA 8.702E-4 1.510E-2
1.111E-1
7.675E-1
 2 175
49 hsa-miR-3664-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.801E-4 1.510E-2
1.111E-1
7.762E-1
 2 176
50 hsa-miR-519e:PITA hsa-miR-519e:PITA TOP PITA 8.801E-4 1.510E-2
1.111E-1
7.762E-1
 2 176
Show 45 more annotations

17: Drug [Display Chart] 18 input genes in category / 4359 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000133020 AC1L320U Stitch 2.121E-23 9.247E-20 8.283E-19 9.247E-20 9 25
2 CID000002544 cantharidic acid Stitch 1.038E-22 2.263E-19 2.027E-18 4.527E-19 9 29
3 CID006437058 dinophysistoxin-1 Stitch 2.089E-22 3.035E-19 2.719E-18 9.106E-19 9 31
4 CID000003225 endothall Stitch 9.738E-22 1.061E-18 9.505E-18 4.245E-18 9 36
5 CID000002545 NSC190421 Stitch 4.556E-20 3.972E-17 3.558E-16 1.986E-16 9 53
6 CID000003422 AC1L1FWE Stitch 2.314E-17 1.681E-14 1.506E-13 1.009E-13 9 102
7 CID000440646 tautomycin Stitch 8.982E-17 5.593E-14 5.010E-13 3.915E-13 9 118
8 CID000445433 microcystin-LR Stitch 2.051E-16 1.117E-13 1.001E-12 8.939E-13 9 129
9 CID000447564 Ph-F Stitch 5.658E-16 2.741E-13 2.455E-12 2.467E-12 9 144
10 CID011530041 inhibitor 1 Stitch 6.425E-16 2.800E-13 2.508E-12 2.800E-12 9 146
11 CID000914489 AC1LIZYF Stitch 2.462E-15 9.755E-13 8.737E-12 1.073E-11 9 169
12 CID000000378 p-nitrophenyl phosphate Stitch 8.687E-15 3.156E-12 2.827E-11 3.787E-11 9 194
13 CID000448772 32 P Stitch 1.061E-13 3.557E-11 3.186E-10 4.624E-10 10 405
14 CID000002505 C2-ceramide Stitch 4.008E-13 1.248E-10 1.118E-9 1.747E-9 9 296
15 CID000004122 nocodazole Stitch 5.528E-13 1.606E-10 1.439E-9 2.410E-9 10 478
16 CID000002534 NSC611747 Stitch 1.905E-12 5.191E-10 4.650E-9 8.306E-9 9 352
17 CID006443962 phoslactomycin A Stitch 1.759E-6 4.510E-4 4.040E-3 7.667E-3 2 3
18 CID006441265 Microcystin Ll Stitch 3.516E-6 8.515E-4 7.627E-3 1.533E-2 2 4
19 CID004478245 AC1NAK0T Stitch 5.857E-6 1.344E-3 1.204E-2 2.553E-2 2 5
20 ctd:D002166 Camptothecin CTD 7.075E-6 1.542E-3 1.381E-2 3.084E-2 4 163
21 ctd:C012606 4-vinyl-1-cyclohexene dioxide CTD 8.355E-6 1.734E-3 1.553E-2 3.642E-2 4 170
22 ctd:C076221 dinophysistoxin 2 CTD 8.782E-6 1.740E-3 1.559E-2 3.828E-2 2 6
23 CID000024403 TSPP Stitch 1.171E-5 2.219E-3 1.988E-2
5.103E-2
 3 57
24 6643 DN Thioguanosine [85-31-4]; Down 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.435E-5 2.555E-3 2.289E-2
6.256E-2
 4 195
25 2892 UP Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.494E-5 2.555E-3 2.289E-2
6.512E-2
 4 197
26 6139 UP D-cycloserine [68-41-7]; Up 200; 39.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.524E-5 2.555E-3 2.289E-2
6.643E-2
 4 198
27 CID000134856 N-methyldehydroalanine Stitch 1.638E-5 2.644E-3 2.368E-2
7.139E-2
 2 8
28 CID000007104 B on A Stitch 2.331E-5 3.629E-3 3.251E-2
1.016E-1
 5 464
29 DB00163 Vitamin E Drug Bank 2.630E-5 3.953E-3 3.541E-2
1.146E-1
 2 10
30 ctd:C051904 dinophysistoxin 1 CTD 3.213E-5 4.668E-3 4.181E-2
1.400E-1
 2 11
31 ctd:C501517 UCF 101 CTD 4.552E-5 6.200E-3
5.554E-2
1.984E-1
 2 13
32 ctd:C108637 aspartyl-glutamyl-valyl-aspartal CTD 4.552E-5 6.200E-3
5.554E-2
1.984E-1
 2 13
33 CID005494429 motuporin Stitch 5.308E-5 7.011E-3
6.280E-2
2.314E-1
 2 14
34 CID000007413 cyclohexane-1-carboxylate Stitch 7.921E-5 9.921E-3
8.887E-2
3.453E-1
 2 17
35 CID000005235 sodium fluoride Stitch 7.966E-5 9.921E-3
8.887E-2
3.472E-1
 3 108
36 ctd:C068329 clofarabine CTD 1.221E-4 1.478E-2
1.324E-1
5.322E-1
 2 21
37 CID000446186 1i32 Stitch 1.350E-4 1.590E-2
1.424E-1
5.883E-1
 3 129
38 CID000004607 Bactocill Stitch 1.544E-4 1.771E-2
1.586E-1
6.730E-1
 3 135
39 CID000010736 CAP palmitate Stitch 1.602E-4 1.791E-2
1.604E-1
6.985E-1
 2 24
40 CID000098527 Nexus Stitch 2.191E-4 2.338E-2
2.094E-1
9.550E-1
 3 152
41 CID000005510 tolnaftate Stitch 2.691E-4 2.338E-2
2.094E-1
1.000E0
 2 31
42 CID000161280 deoxycytosine Stitch 3.053E-4 2.338E-2
2.094E-1
1.000E0
 2 33
43 3998 DN Etifenin [63245-28-3]; Down 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.484E-4 2.338E-2
2.094E-1
1.000E0
 3 178
44 CID010197840 (3S,4R,5R)-5-methylolpiperidine-2,3,4-triol Stitch 3.843E-4 2.338E-2
2.094E-1
1.000E0
 2 37
45 CID000007264 2a-c Stitch 3.843E-4 2.338E-2
2.094E-1
1.000E0
 2 37
46 6735 DN Neostigmine bromide [114-80-7]; Down 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 4.088E-4 2.338E-2
2.094E-1
1.000E0
 3 188
47 4688 UP Dilazep dihydrochloride [20153-98-4]; Up 200; 6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.152E-4 2.338E-2
2.094E-1
1.000E0
 3 189
48 7062 UP GW8510; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.348E-4 2.338E-2
2.094E-1
1.000E0
 3 192
49 997 UP chlorpromazine hydrochloride; Up 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 4.414E-4 2.338E-2
2.094E-1
1.000E0
 3 193
50 1297 DN Suloctidil [54063-56-8]; Down 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 4.414E-4 2.338E-2
2.094E-1
1.000E0
 3 193
Show 45 more annotations

18: Disease [Display Chart] 18 input genes in category / 300 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0270972 Cornelia De Lange Syndrome DisGeNET Curated 6.302E-9 1.723E-6 1.082E-5 1.890E-6 4 21
2 C0271007 Phthisis bulbi DisGeNET Curated 1.149E-8 1.723E-6 1.082E-5 3.447E-6 3 5
3 C4023915 Abnormally low-pitched voice DisGeNET Curated 2.297E-8 1.723E-6 1.082E-5 6.890E-6 3 6
4 C2673670 Curly eyelashes DisGeNET Curated 2.297E-8 1.723E-6 1.082E-5 6.890E-6 3 6
5 C0263401 Cutis marmorata DisGeNET Curated 4.839E-8 2.904E-6 1.824E-5 1.452E-5 4 34
6 C1849311 Short first metacarpals DisGeNET Curated 1.888E-7 9.441E-6 5.931E-5 5.665E-5 3 11
7 C0432355 Hypoplasia of nipple DisGeNET Curated 6.386E-7 2.113E-5 1.328E-4 1.916E-4 3 16
8 C0566899 Small labia majora DisGeNET Curated 6.386E-7 2.113E-5 1.328E-4 1.916E-4 3 16
9 C1857641 Severe postnatal growth retardation DisGeNET Curated 6.386E-7 2.113E-5 1.328E-4 1.916E-4 3 16
10 C0339063 Cellulitis of eyelid DisGeNET Curated 7.749E-7 2.113E-5 1.328E-4 2.325E-4 3 17
11 C1865572 Proximally placed thumbs DisGeNET Curated 7.749E-7 2.113E-5 1.328E-4 2.325E-4 3 17
12 C0005741 Blepharitis DisGeNET Curated 1.103E-6 2.757E-5 1.732E-4 3.308E-4 3 19
13 C1857079 Atretic auditory canal DisGeNET Curated 2.010E-6 3.768E-5 2.368E-4 6.029E-4 3 23
14 C1840305 Absent external auditory canals DisGeNET Curated 2.010E-6 3.768E-5 2.368E-4 6.029E-4 3 23
15 C1866190 Atresia of the external auditory canal DisGeNET Curated 2.010E-6 3.768E-5 2.368E-4 6.029E-4 3 23
16 C1398325 Absent auditory canals DisGeNET Curated 2.010E-6 3.768E-5 2.368E-4 6.029E-4 3 23
17 C0158761 Radioulnar Synostosis DisGeNET Curated 2.607E-6 4.600E-5 2.890E-4 7.820E-4 3 25
18 C1854630 Growth Deficiency and Mental Retardation with Facial Dysmorphism DisGeNET Curated 3.494E-6 5.516E-5 3.466E-4 1.048E-3 2 3
19 C1858501 Spinocerebellar Ataxia 12 DisGeNET Curated 3.494E-6 5.516E-5 3.466E-4 1.048E-3 2 3
20 C1842366 Low anterior hairline DisGeNET Curated 4.585E-6 6.878E-5 4.321E-4 1.376E-3 3 30
21 C1844813 Widely spaced teeth DisGeNET Curated 5.073E-6 7.247E-5 4.553E-4 1.522E-3 3 31
22 C1862095 Bilateral single transverse palmar creases DisGeNET Curated 6.739E-6 9.190E-5 5.774E-4 2.022E-3 3 34
23 C1849211 Generalized hirsutism DisGeNET Curated 8.030E-6 1.047E-4 6.580E-4 2.409E-3 3 36
24 C1853738 Long eyelashes DisGeNET Curated 8.733E-6 1.092E-4 6.858E-4 2.620E-3 3 37
25 C0575802 Small hand DisGeNET Curated 1.026E-5 1.231E-4 7.733E-4 3.077E-3 3 39
26 C0431447 Synophrys DisGeNET Curated 1.108E-5 1.236E-4 7.765E-4 3.324E-3 3 40
27 C4020849 Bowed and upward slanting eyebrows DisGeNET Curated 1.195E-5 1.236E-4 7.765E-4 3.584E-3 3 41
28 C0600104 Obsessive compulsive behavior DisGeNET Curated 1.195E-5 1.236E-4 7.765E-4 3.584E-3 3 41
29 C1868571 Thick, flared eyebrows DisGeNET Curated 1.195E-5 1.236E-4 7.765E-4 3.584E-3 3 41
30 C1849955 Limited elbow movement DisGeNET Curated 1.743E-5 1.697E-4 1.066E-3 5.230E-3 2 6
31 C0265660 Syndactyly of the toes DisGeNET Curated 1.810E-5 1.697E-4 1.066E-3 5.429E-3 3 47
32 C1167713 Corneal diameter decreased DisGeNET Curated 1.810E-5 1.697E-4 1.066E-3 5.429E-3 3 47
33 C0266544 Microcornea DisGeNET Curated 1.929E-5 1.754E-4 1.102E-3 5.787E-3 3 48
34 C0578038 Thin lips DisGeNET Curated 2.053E-5 1.760E-4 1.106E-3 6.160E-3 3 49
35 C1853487 Bushy eyebrows DisGeNET Curated 2.053E-5 1.760E-4 1.106E-3 6.160E-3 3 49
36 C1866195 Downturned corners of mouth DisGeNET Curated 2.318E-5 1.891E-4 1.188E-3 6.953E-3 3 51
37 C0392475 Roberts-SC phocomelia syndrome DisGeNET Curated 2.439E-5 1.891E-4 1.188E-3 7.317E-3 2 7
38 C0036857 Severe mental retardation (I.Q. 20-34) DisGeNET Curated 2.453E-5 1.891E-4 1.188E-3 7.360E-3 4 159
39 C1855728 Low posterior hairline DisGeNET Curated 2.458E-5 1.891E-4 1.188E-3 7.374E-3 3 52
40 C3714581 Multicystic Dysplastic Kidney DisGeNET Curated 2.912E-5 2.184E-4 1.372E-3 8.736E-3 3 55
41 C1257806 Chromosomal Instability DisGeNET Curated 3.250E-5 2.378E-4 1.494E-3 9.750E-3 2 8
42 C1386048 Intrauterine retardation DisGeNET Curated 3.735E-5 2.581E-4 1.621E-3 1.121E-2 4 177
43 C0021296 Infant, Small for Gestational Age DisGeNET Curated 3.735E-5 2.581E-4 1.621E-3 1.121E-2 4 177
44 C0025995 Micromelia DisGeNET Curated 3.785E-5 2.581E-4 1.621E-3 1.135E-2 3 60
45 C0239174 Late tooth eruption DisGeNET Curated 3.978E-5 2.652E-4 1.666E-3 1.193E-2 3 61
46 C0015934 Fetal Growth Retardation DisGeNET Curated 4.534E-5 2.957E-4 1.858E-3 1.360E-2 4 186
47 C0042580 Vesico-Ureteral Reflux DisGeNET Curated 4.815E-5 3.073E-4 1.931E-3 1.444E-2 3 65
48 C1840077 Anteverted nostril DisGeNET Curated 5.028E-5 3.143E-4 1.974E-3 1.508E-2 4 191
49 C0233315 Premature birth of newborn DisGeNET Curated 5.273E-5 3.228E-4 2.028E-3 1.582E-2 3 67
50 C1848673 Hypoplastic feet DisGeNET Curated 5.759E-5 3.455E-4 2.171E-3 1.728E-2 3 69
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