Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc88_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 27 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1905030 voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential 5.920E-12 7.992E-11 3.110E-10 1.598E-10 4 21
2 GO:0005248 voltage-gated sodium channel activity 5.920E-12 7.992E-11 3.110E-10 1.598E-10 4 21
3 GO:0005272 sodium channel activity 6.528E-11 5.876E-10 2.286E-9 1.763E-9 4 37
4 GO:0031402 sodium ion binding 5.166E-9 3.487E-8 1.357E-7 1.395E-7 3 16
5 GO:0015081 sodium ion transmembrane transporter activity 1.342E-8 7.246E-8 2.820E-7 3.623E-7 4 136
6 GO:0031420 alkali metal ion binding 1.633E-8 7.348E-8 2.859E-7 4.409E-7 3 23
7 GO:0022832 voltage-gated channel activity 6.098E-8 2.058E-7 8.008E-7 1.646E-6 4 198
8 GO:0005244 voltage-gated ion channel activity 6.098E-8 2.058E-7 8.008E-7 1.646E-6 4 198
9 GO:0005261 cation channel activity 3.500E-7 1.050E-6 4.086E-6 9.450E-6 4 306
10 GO:0022836 gated channel activity 4.793E-7 1.294E-6 5.036E-6 1.294E-5 4 331
11 GO:0015077 monovalent inorganic cation transmembrane transporter activity 7.899E-7 1.939E-6 7.545E-6 2.133E-5 4 375
12 GO:0005216 ion channel activity 1.291E-6 2.731E-6 1.063E-5 3.485E-5 4 424
13 GO:0046873 metal ion transmembrane transporter activity 1.315E-6 2.731E-6 1.063E-5 3.551E-5 4 426
14 GO:0022838 substrate-specific channel activity 1.469E-6 2.834E-6 1.103E-5 3.967E-5 4 438
15 GO:0015267 channel activity 1.947E-6 3.314E-6 1.290E-5 5.258E-5 4 470
16 GO:0022803 passive transmembrane transporter activity 1.964E-6 3.314E-6 1.290E-5 5.303E-5 4 471
17 GO:0043522 leucine zipper domain binding 3.479E-3 5.525E-3 2.150E-2
9.393E-2
 1 13
18 GO:0030275 LRR domain binding 5.348E-3 8.022E-3 3.122E-2
1.444E-1
 1 20
19 GO:0097472 cyclin-dependent protein kinase activity 9.344E-3 1.261E-2 4.909E-2
2.523E-1
 1 35
20 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 9.344E-3 1.261E-2 4.909E-2
2.523E-1
 1 35
21 GO:0048365 Rac GTPase binding 1.120E-2 1.441E-2
5.606E-2
3.025E-1
 1 42
22 GO:0017048 Rho GTPase binding 2.310E-2 2.835E-2
1.103E-1
6.236E-1
 1 87
Show 17 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 85 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019228 neuronal action potential 1.009E-10 5.748E-9 2.889E-8 8.577E-9 4 41
2 GO:0086010 membrane depolarization during action potential 1.352E-10 5.748E-9 2.889E-8 1.150E-8 4 44
3 GO:0019226 transmission of nerve impulse 1.573E-9 4.457E-8 2.240E-7 1.337E-7 4 80
4 GO:0060078 regulation of postsynaptic membrane potential 3.897E-9 7.768E-8 3.904E-7 3.313E-7 4 100
5 GO:0051899 membrane depolarization 4.569E-9 7.768E-8 3.904E-7 3.884E-7 4 104
6 GO:0035725 sodium ion transmembrane transport 1.199E-8 1.699E-7 8.538E-7 1.019E-6 4 132
7 GO:0001508 action potential 1.435E-8 1.743E-7 8.758E-7 1.220E-6 4 138
8 GO:0035637 multicellular organismal signaling 6.024E-8 6.400E-7 3.216E-6 5.120E-6 4 197
9 GO:0006814 sodium ion transport 9.051E-8 8.548E-7 4.296E-6 7.694E-6 4 218
10 GO:0042391 regulation of membrane potential 9.411E-7 8.000E-6 4.020E-5 8.000E-5 4 391
11 GO:0034765 regulation of ion transmembrane transport 1.725E-6 1.333E-5 6.698E-5 1.466E-4 4 455
12 GO:0034762 regulation of transmembrane transport 2.014E-6 1.426E-5 7.169E-5 1.712E-4 4 473
13 GO:0046684 response to pyrethroid 1.342E-3 8.147E-3 4.094E-2
1.141E-1
 1 5
14 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress 1.342E-3 8.147E-3 4.094E-2
1.141E-1
 1 5
15 GO:0098870 action potential propagation 2.146E-3 1.140E-2
5.730E-2
1.824E-1
 1 8
16 GO:0019227 neuronal action potential propagation 2.146E-3 1.140E-2
5.730E-2
1.824E-1
 1 8
17 GO:0015871 choline transport 2.950E-3 1.475E-2
7.413E-2
2.508E-1
 1 11
18 GO:0017085 response to insecticide 3.486E-3 1.646E-2
8.273E-2
2.963E-1
 1 13
19 GO:0050884 neuromuscular process controlling posture 4.289E-3 1.919E-2
9.643E-2
3.646E-1
 1 16
20 GO:0071236 cellular response to antibiotic 4.824E-3 2.050E-2
1.030E-1
4.100E-1
 1 18
21 GO:0071470 cellular response to osmotic stress 6.962E-3 2.793E-2
1.404E-1
5.918E-1
 1 26
22 GO:0097237 cellular response to toxic substance 7.229E-3 2.793E-2
1.404E-1
6.145E-1
 1 27
23 GO:0090659 walking behavior 1.096E-2 3.817E-2
1.918E-1
9.317E-1
 1 41
24 GO:0007628 adult walking behavior 1.096E-2 3.817E-2
1.918E-1
9.317E-1
 1 41
25 GO:0050775 positive regulation of dendrite morphogenesis 1.123E-2 3.817E-2
1.918E-1
9.543E-1
 1 42
26 GO:0045773 positive regulation of axon extension 1.202E-2 3.931E-2
1.976E-1
1.000E0
 1 45
27 GO:0046677 response to antibiotic 1.362E-2 4.288E-2
2.155E-1
1.000E0
 1 51
Show 22 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 34 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001518 voltage-gated sodium channel complex 9.099E-13 3.094E-11 1.274E-10 3.094E-11 4 14
2 GO:0034706 sodium channel complex 2.163E-12 3.677E-11 1.514E-10 7.355E-11 4 17
3 GO:0034703 cation channel complex 3.488E-8 3.953E-7 1.628E-6 1.186E-6 4 176
4 GO:0034702 ion channel complex 2.629E-7 2.235E-6 9.204E-6 8.940E-6 4 291
5 GO:1902495 transmembrane transporter complex 4.196E-7 2.557E-6 1.053E-5 1.426E-5 4 327
6 GO:1990351 transporter complex 4.512E-7 2.557E-6 1.053E-5 1.534E-5 4 333
7 GO:0043194 axon initial segment 4.289E-6 2.083E-5 8.579E-5 1.458E-4 2 13
8 GO:0033268 node of Ranvier 6.596E-6 2.803E-5 1.155E-4 2.243E-4 2 16
9 GO:0014704 intercalated disc 9.046E-5 3.293E-4 1.356E-3 3.076E-3 2 58
10 GO:0030315 T-tubule 9.685E-5 3.293E-4 1.356E-3 3.293E-3 2 60
11 GO:0044291 cell-cell contact zone 1.358E-4 4.181E-4 1.722E-3 4.618E-3 2 71
12 GO:0044304 main axon 1.476E-4 4.181E-4 1.722E-3 5.017E-3 2 74
13 GO:0042383 sarcolemma 6.219E-4 1.626E-3 6.698E-3 2.114E-2 2 152
14 GO:0044294 dendritic growth cone 1.311E-3 3.184E-3 1.311E-2 4.457E-2 1 5
15 GO:0033267 axon part 2.536E-3 5.749E-3 2.367E-2
8.623E-2
 2 309
16 GO:0044292 dendrite terminus 3.406E-3 7.237E-3 2.980E-2
1.158E-1
 1 13
17 GO:0033270 paranode region of axon 3.929E-3 7.858E-3 3.236E-2
1.336E-1
 1 15
18 GO:0005911 cell-cell junction 4.592E-3 8.673E-3 3.572E-2
1.561E-1
 2 418
19 GO:0032839 dendrite cytoplasm 5.497E-3 9.837E-3 4.051E-2
1.869E-1
 1 21
20 GO:0032838 plasma membrane bounded cell projection cytoplasm 1.642E-2 2.791E-2
1.149E-1
5.582E-1
 1 63
21 GO:0032587 ruffle membrane 2.184E-2 3.537E-2
1.456E-1
7.427E-1
 1 84
22 GO:0030018 Z disc 3.083E-2 4.765E-2
1.962E-1
1.000E0
 1 119
Show 17 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 447 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007270 Atypical absence seizure 3.536E-7 1.580E-4 1.056E-3 1.580E-4 3 22
2 HP:0002121 Absence seizure 5.665E-6 7.521E-4 5.025E-3 2.532E-3 3 54
3 HP:0200134 Epileptic encephalopathy 1.043E-5 7.521E-4 5.025E-3 4.663E-3 3 66
4 HP:0002373 Febrile seizures 1.247E-5 7.521E-4 5.025E-3 5.574E-3 3 70
5 HP:0011146 Dialeptic seizures 1.302E-5 7.521E-4 5.025E-3 5.819E-3 3 71
6 HP:0005484 Postnatal microcephaly 1.358E-5 7.521E-4 5.025E-3 6.072E-3 3 72
7 HP:0025356 Psychomotor retardation 1.514E-5 7.521E-4 5.025E-3 6.769E-3 2 8
8 HP:0031475 Nonconvulsive status epilepticus 1.514E-5 7.521E-4 5.025E-3 6.769E-3 2 8
9 HP:0011151 Obtundation status 1.514E-5 7.521E-4 5.025E-3 6.769E-3 2 8
10 HP:0006813 Hemiclonic seizures 1.946E-5 8.700E-4 5.813E-3 8.700E-3 2 9
11 HP:0002123 Generalized myoclonic seizures 2.325E-5 9.060E-4 6.053E-3 1.039E-2 3 86
12 HP:0012534 Dysesthesia 2.432E-5 9.060E-4 6.053E-3 1.087E-2 2 10
13 HP:0002266 Focal clonic seizures 2.972E-5 9.713E-4 6.489E-3 1.328E-2 2 11
14 HP:0011182 Interictal epileptiform activity 3.042E-5 9.713E-4 6.489E-3 1.360E-2 3 94
15 HP:0001270 Motor delay 4.142E-5 1.234E-3 8.247E-3 1.852E-2 4 379
16 HP:0002133 Status epilepticus 5.020E-5 1.402E-3 9.370E-3 2.244E-2 3 111
17 HP:0007359 Focal-onset seizure 6.347E-5 1.669E-3 1.115E-2 2.837E-2 3 120
18 HP:0007334 Generalized tonic-clonic seizures with focal onset 8.251E-5 2.049E-3 1.369E-2 3.688E-2 2 18
19 HP:0012469 Infantile spasms 1.615E-4 3.799E-3 2.538E-2
7.217E-2
 2 25
20 HP:0002197 Generalized-onset seizure 2.594E-4 5.671E-3 3.789E-2
1.159E-1
 3 192
21 HP:0011153 Focal motor seizure 2.664E-4 5.671E-3 3.789E-2
1.191E-1
 2 32
22 HP:0002384 Focal impaired awareness seizure 3.972E-4 8.071E-3
5.392E-2
1.776E-1
 2 39
23 HP:0011097 Epileptic spasms 6.031E-4 1.172E-2
7.831E-2
2.696E-1
 2 48
24 HP:0001336 Myoclonus 7.471E-4 1.392E-2
9.297E-2
3.340E-1
 3 274
25 HP:0100021 Cerebral palsy 9.432E-4 1.686E-2
1.127E-1
4.216E-1
 2 60
26 HP:0100704 Cerebral visual impairment 1.073E-3 1.832E-2
1.224E-1
4.796E-1
 2 64
27 HP:0002357 Dysphasia 1.107E-3 1.832E-2
1.224E-1
4.947E-1
 2 65
28 HP:0002521 Hypsarrhythmia 1.211E-3 1.933E-2
1.292E-1
5.414E-1
 2 68
29 HP:0001298 Encephalopathy 1.390E-3 2.143E-2
1.432E-1
6.215E-1
 3 338
30 HP:0011809 Paradoxical myotonia 1.699E-3 2.373E-2
1.586E-1
7.595E-1
 1 2
31 HP:0007667 Peripheral cystoid retinal degeneration 1.699E-3 2.373E-2
1.586E-1
7.595E-1
 1 2
32 HP:0030824 Mizuo phenomenon 1.699E-3 2.373E-2
1.586E-1
7.595E-1
 1 2
33 HP:0002353 EEG abnormality 1.758E-3 2.382E-2
1.591E-1
7.860E-1
 3 366
34 HP:0011198 EEG with generalized epileptiform discharges 2.024E-3 2.660E-2
1.777E-1
9.045E-1
 2 88
35 HP:0001337 Tremor 2.136E-3 2.728E-2
1.822E-1
9.547E-1
 3 391
36 HP:0012899 Handgrip myotonia 2.548E-3 3.078E-2
2.056E-1
1.000E0
 1 3
37 HP:0010521 Gait apraxia 2.548E-3 3.078E-2
2.056E-1
1.000E0
 1 3
38 HP:0002069 Generalized tonic-clonic seizures 2.818E-3 3.161E-2
2.112E-1
1.000E0
 2 104
39 HP:0001268 Mental deterioration 3.082E-3 3.161E-2
2.112E-1
1.000E0
 3 443
40 HP:0002489 Psychomotor regression 3.082E-3 3.161E-2
2.112E-1
1.000E0
 3 443
41 HP:0002059 Cerebral atrophy 3.376E-3 3.161E-2
2.112E-1
1.000E0
 3 457
42 HP:0011195 EEG with focal sharp slow waves 3.396E-3 3.161E-2
2.112E-1
1.000E0
 1 4
43 HP:0012726 Episodic hypokalemia 3.396E-3 3.161E-2
2.112E-1
1.000E0
 1 4
44 HP:0003752 Episodic flaccid weakness 3.396E-3 3.161E-2
2.112E-1
1.000E0
 1 4
45 HP:0031165 Multifocal seizures 3.396E-3 3.161E-2
2.112E-1
1.000E0
 1 4
46 HP:0025425 Laryngospasm 3.396E-3 3.161E-2
2.112E-1
1.000E0
 1 4
47 HP:0030178 Abnormality of central nervous system electrophysiology 3.619E-3 3.161E-2
2.112E-1
1.000E0
 3 468
48 HP:0007369 Atrophy/Degeneration affecting the cerebrum 3.756E-3 3.161E-2
2.112E-1
1.000E0
 3 474
49 HP:0000992 Cutaneous photosensitivity 3.802E-3 3.161E-2
2.112E-1
1.000E0
 2 121
50 HP:0003401 Paresthesia 3.990E-3 3.161E-2
2.112E-1
1.000E0
 2 124
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 151 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002690 akinesia 5.127E-5 7.741E-3 4.333E-2 7.741E-3 2 24
2 MP:0001951 abnormal breathing pattern 3.923E-4 1.458E-2
8.163E-2
5.924E-2
 3 359
3 MP:0002272 abnormal nervous system electrophysiology 3.923E-4 1.458E-2
8.163E-2
5.924E-2
 3 359
4 MP:0012444 thin hippocampus molecular cell layer 4.829E-4 1.458E-2
8.163E-2
7.291E-2
 1 1
5 MP:0012446 thin hippocampus stratum oriens 4.829E-4 1.458E-2
8.163E-2
7.291E-2
 1 1
6 MP:0002327 abnormal respiratory function 6.499E-4 1.636E-2
9.155E-2
9.813E-2
 3 426
7 MP:0011150 abnormal hippocampus stratum oriens morphology 9.655E-4 2.083E-2
1.166E-1
1.458E-1
 1 2
8 MP:0000813 abnormal hippocampus layer morphology 1.176E-3 2.219E-2
1.242E-1
1.775E-1
 2 114
9 MP:0008286 abnormal hippocampus molecular cell layer 1.448E-3 2.429E-2
1.360E-1
2.187E-1
 1 3
10 MP:0002194 maximal tonic hindlimb extension seizures 1.930E-3 2.650E-2
1.483E-1
2.915E-1
 1 4
11 MP:0004037 increased muscle relaxation 1.930E-3 2.650E-2
1.483E-1
2.915E-1
 1 4
12 MP:0006110 ventricular fibrillation 2.894E-3 3.642E-2
2.039E-1
4.370E-1
 1 6
13 MP:0009357 abnormal seizure response to inducing agent 3.399E-3 3.948E-2
2.210E-1
5.132E-1
 2 195
14 MP:0008143 abnormal dendrite morphology 4.541E-3 4.847E-2
2.713E-1
6.857E-1
 2 226
15 MP:0008770 decreased survivor rate 5.234E-3 4.847E-2
2.713E-1
7.903E-1
 2 243
16 MP:0001954 respiratory distress 5.840E-3 4.847E-2
2.713E-1
8.818E-1
 2 257
17 MP:0006109 fibrillation 6.263E-3 4.847E-2
2.713E-1
9.457E-1
 1 13
18 MP:0001513 limb grasping 6.338E-3 4.847E-2
2.713E-1
9.570E-1
 2 268
19 MP:0005292 improved glucose tolerance 6.523E-3 4.847E-2
2.713E-1
9.850E-1
 2 272
20 MP:0010748 abnormal visual evoked potential 6.743E-3 4.847E-2
2.713E-1
1.000E0
 1 14
21 MP:0009938 abnormal hippocampus granule cell morphology 6.743E-3 4.847E-2
2.713E-1
1.000E0
 1 14
22 MP:0010831 lethality, incomplete penetrance 7.692E-3 4.847E-2
2.713E-1
1.000E0
 2 296
23 MP:0009732 ventricular premature beat 7.703E-3 4.847E-2
2.713E-1
1.000E0
 1 16
24 MP:0003996 clonic seizures 7.703E-3 4.847E-2
2.713E-1
1.000E0
 1 16
Show 19 more annotations

6: Domain [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF06512 Na trans assoc Pfam 2.046E-13 1.705E-12 6.505E-12 5.114E-12 4 10
2 IPR001696 Na channel asu InterPro 2.046E-13 1.705E-12 6.505E-12 5.114E-12 4 10
3 IPR010526 Na trans assoc InterPro 2.046E-13 1.705E-12 6.505E-12 5.114E-12 4 10
4 IPR024583 Na trans cytopl InterPro 1.825E-10 9.123E-10 3.481E-9 4.562E-9 3 6
5 PF11933 Na trans cytopl Pfam 1.825E-10 9.123E-10 3.481E-9 4.562E-9 3 6
6 1.20.120.350 - Gene3D 3.840E-10 1.371E-9 5.233E-9 9.600E-9 4 57
7 IPR027359 Channel four-helix dom InterPro 3.840E-10 1.371E-9 5.233E-9 9.600E-9 4 57
8 SM00015 IQ SMART 1.616E-9 5.049E-9 1.927E-8 4.039E-8 4 81
9 IPR000048 IQ motif EF-hand-BS InterPro 2.480E-9 6.890E-9 2.629E-8 6.201E-8 4 90
10 PS50096 IQ PROSITE 2.834E-9 7.085E-9 2.704E-8 7.085E-8 4 93
11 PF00520 Ion trans Pfam 6.471E-9 1.348E-8 5.144E-8 1.618E-7 4 114
12 IPR005821 Ion trans dom InterPro 6.471E-9 1.348E-8 5.144E-8 1.618E-7 4 114
13 PF00612 IQ Pfam 5.187E-7 9.976E-7 3.807E-6 1.297E-5 3 71
14 IPR028826 Na channel a4su InterPro 2.669E-4 4.170E-4 1.591E-3 6.672E-3 1 1
15 IPR008051 Na channel a1su InterPro 2.669E-4 4.170E-4 1.591E-3 6.672E-3 1 1
16 IPR008052 Na channel a4su mammal InterPro 2.669E-4 4.170E-4 1.591E-3 6.672E-3 1 1
17 IPR011992 EF-hand-dom pair InterPro 2.268E-3 3.336E-3 1.273E-2
5.671E-2
 2 287
Show 12 more annotations

7: Pathway [Display Chart] 4 input genes in category / 7 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270325 Interaction between L1 and Ankyrins BioSystems: REACTOME 2.739E-11 1.917E-10 4.971E-10 1.917E-10 4 30
2 1339117 Phase 0 - rapid depolarisation BioSystems: REACTOME 1.783E-10 6.239E-10 1.618E-9 1.248E-9 4 47
3 1270323 L1CAM interactions BioSystems: REACTOME 4.247E-9 9.910E-9 2.569E-8 2.973E-8 4 102
4 1339115 Cardiac conduction BioSystems: REACTOME 1.622E-8 2.839E-8 7.362E-8 1.136E-7 4 142
5 1269868 Muscle contraction BioSystems: REACTOME 7.002E-8 9.802E-8 2.542E-7 4.901E-7 4 204
6 83088 Taste transduction BioSystems: KEGG 2.612E-4 3.047E-4 7.901E-4 1.828E-3 2 83
7 469199 Dopaminergic synapse BioSystems: KEGG 4.112E-2 4.112E-2
1.066E-1
2.879E-1
 1 130
Show 2 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 736 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15746173 Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart. Pubmed 7.106E-15 2.615E-12 1.877E-11 5.230E-12 4 9
2 16382098 International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pubmed 7.106E-15 2.615E-12 1.877E-11 5.230E-12 4 9
3 12610651 Sodium channels SCN1A, SCN2A and SCN3A in familial autism. Pubmed 1.077E-12 1.132E-10 8.130E-10 7.927E-10 3 3
4 23859570 SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis. Pubmed 1.077E-12 1.132E-10 8.130E-10 7.927E-10 3 3
5 14973256 Early expression of sodium channel transcripts and sodium current by cajal-retzius cells in the preplate of the embryonic mouse neocortex. Pubmed 1.077E-12 1.132E-10 8.130E-10 7.927E-10 3 3
6 18784617 Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression. Pubmed 1.077E-12 1.132E-10 8.130E-10 7.927E-10 3 3
7 17544618 Characterization of 5' untranslated regions of the voltage-gated sodium channels SCN1A, SCN2A, and SCN3A and identification of cis-conserved noncoding sequences. Pubmed 1.077E-12 1.132E-10 8.130E-10 7.927E-10 3 3
8 17537961 Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. Pubmed 4.308E-12 3.523E-10 2.529E-9 3.171E-9 3 4
9 8974318 Use of recombinant inbred strains for studying genetic determinants of responses to alcohol. Pubmed 4.308E-12 3.523E-10 2.529E-9 3.171E-9 3 4
10 17724025 Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. Pubmed 1.077E-11 6.097E-10 4.377E-9 7.926E-9 3 5
11 1679748 Three brain sodium channel alpha-subunit genes are clustered on the proximal segment of mouse chromosome 2. Pubmed 1.077E-11 6.097E-10 4.377E-9 7.926E-9 3 5
12 24337656 Case-control association study of polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, SCN3A, SCN1B, and SCN2B and epilepsy. Pubmed 1.077E-11 6.097E-10 4.377E-9 7.926E-9 3 5
13 8812438 A new sodium channel alpha-subunit gene (Scn9a) from Schwann cells maps to the Scn1a, Scn2a, Scn3a cluster of mouse chromosome 2. Pubmed 1.077E-11 6.097E-10 4.377E-9 7.926E-9 3 5
14 23652591 A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. Pubmed 2.154E-11 1.132E-9 8.129E-9 1.585E-8 3 6
15 15123669 Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. Pubmed 2.369E-10 1.090E-8 7.822E-8 1.743E-7 3 12
16 8169823 Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice. Pubmed 2.369E-10 1.090E-8 7.822E-8 1.743E-7 3 12
17 9726281 Confirmation of quantitative trait loci for alcohol preference in mice. Pubmed 3.079E-10 1.333E-8 9.570E-8 2.266E-7 3 13
18 27690330 Mapping of a FEB3 homologous febrile seizure locus on mouse chromosome 2 containing candidate genes Scn1a and Scn3a. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
19 11245985 Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
20 23965409 Correlations in timing of sodium channel expression, epilepsy, and sudden death in Dravet syndrome. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
21 19694741 Differential role of sodium channels SCN1A and SCN2A gene polymorphisms with epilepsy and multiple drug resistance in the north Indian population. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
22 21377452 The developmental changes of Na(v)1.1 and Na(v)1.2 expression in the human hippocampus and temporal lobe. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
23 1317301 Differential expression of two sodium channel subtypes in human brain. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
24 27153334 Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
25 10827969 Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
26 20346423 Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
27 15249644 Severe epilepsy, retardation, and dysmorphic features with a 2q deletion including SCN1A and SCN2A. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
28 26311622 Missense mutations in sodium channel SCN1A and SCN2A predispose children to encephalopathy with severe febrile seizures. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
29 28784306 Nav1.2 is expressed in caudal ganglionic eminence-derived disinhibitory interneurons: Mutually exclusive distributions of Nav1.1 and Nav1.2. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
30 24990319 Electrophysiological Differences between the Same Pore Region Mutation in SCN1A and SCN3A. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
31 29649454 Association between SCN1A and SCN2A mutations and clinical/EEG features in Chinese patients from epilepsy or severe seizures. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
32 23016767 Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy. Pubmed 1.371E-8 3.154E-7 2.264E-6 1.009E-5 2 2
33 16052353 Identification of functional voltage-gated Na(+) channels in cultured human pulmonary artery smooth muscle cells. Pubmed 4.113E-8 7.966E-7 5.719E-6 3.027E-5 2 3
34 19270815 Gene-to-gene interaction between sodium channel-related genes in determining the risk of antiepileptic drug resistance. Pubmed 4.113E-8 7.966E-7 5.719E-6 3.027E-5 2 3
35 28518218 Comparison and optimization of in silico algorithms for predicting the pathogenicity of sodium channel variants in epilepsy. Pubmed 4.113E-8 7.966E-7 5.719E-6 3.027E-5 2 3
36 19284629 Voltage-gated sodium channels in taste bud cells. Pubmed 4.113E-8 7.966E-7 5.719E-6 3.027E-5 2 3
37 25155934 Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy. Pubmed 4.113E-8 7.966E-7 5.719E-6 3.027E-5 2 3
38 17928448 Reduced sodium current in Purkinje neurons from Nav1.1 mutant mice: implications for ataxia in severe myoclonic epilepsy in infancy. Pubmed 4.113E-8 7.966E-7 5.719E-6 3.027E-5 2 3
39 8751373 Report and abstracts of the Fourth International Workshop on Human Chromosome 2 Mapping 1996. Pubmed 5.147E-8 9.713E-7 6.973E-6 3.788E-5 3 67
40 26637798 Targeted DNA Sequencing from Autism Spectrum Disorder Brains Implicates Multiple Genetic Mechanisms. Pubmed 8.226E-8 1.477E-6 1.060E-5 6.054E-5 2 4
41 21156207 Neuronal voltage-gated ion channels are genetic modifiers of generalized epilepsy with febrile seizures plus. Pubmed 8.226E-8 1.477E-6 1.060E-5 6.054E-5 2 4
42 25818041 Diagnostic yield of genetic testing in epileptic encephalopathy in childhood. Pubmed 2.879E-7 5.044E-6 3.621E-5 2.119E-4 2 7
43 9412493 Interaction of muscle and brain sodium channels with multiple members of the syntrophin family of dystrophin-associated proteins. Pubmed 3.838E-7 6.569E-6 4.716E-5 2.825E-4 2 8
44 16985003 Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Pubmed 4.491E-7 7.513E-6 5.394E-5 3.306E-4 3 137
45 25344690 Common variants associated with general and MMR vaccine-related febrile seizures. Pubmed 6.167E-7 9.868E-6 7.084E-5 4.539E-4 2 10
46 20602612 Genetic profile of patients with epilepsy on first-line antiepileptic drugs and potential directions for personalized treatment. Pubmed 6.167E-7 9.868E-6 7.084E-5 4.539E-4 2 10
47 24579881 Exome sequencing identifies a de novo SCN2A mutation in a patient with intractable seizures, severe intellectual disability, optic atrophy, muscular hypotonia, and brain abnormalities. Pubmed 1.309E-4 1.794E-4 1.288E-3
9.635E-2
 1 1
48 22780858 Dravet syndrome: seizure control and gait in adults with different SCN1A mutations. Pubmed 1.309E-4 1.794E-4 1.288E-3
9.635E-2
 1 1
49 23064044 Validation of high-resolution DNA melting analysis for mutation scanning of the CDKL5 gene: identification of novel mutations. Pubmed 1.309E-4 1.794E-4 1.288E-3
9.635E-2
 1 1
50 22591750 Acute encephalopathy with a novel point mutation in the SCN2A gene. Pubmed 1.309E-4 1.794E-4 1.288E-3
9.635E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 44 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NEDD4L NEDD4L interactions 1.711E-5 7.529E-4 3.292E-3 7.529E-4 3 214
2 int:SNTA1 SNTA1 interactions 2.587E-4 5.692E-3 2.489E-2 1.138E-2 2 91
3 int:SCN4B SCN4B interactions 8.471E-4 1.242E-2
5.432E-2
 3.727E-2 1 3
4 int:ARHGEF10L ARHGEF10L interactions 1.412E-3 1.242E-2
5.432E-2
6.211E-2
 1 5
5 int:SCN1A SCN1A interactions 1.412E-3 1.242E-2
5.432E-2
6.211E-2
 1 5
6 int:SCN3A SCN3A interactions 1.976E-3 1.419E-2
6.205E-2
8.693E-2
 1 7
7 int:SCN2A SCN2A interactions 2.258E-3 1.419E-2
6.205E-2
9.934E-2
 1 8
8 int:SCN4A SCN4A interactions 3.103E-3 1.707E-2
7.463E-2
1.365E-1
 1 11
9 int:PRKG2 PRKG2 interactions 3.667E-3 1.772E-2
7.746E-2
1.613E-1
 1 13
10 int:CDKL5 CDKL5 interactions 5.074E-3 1.772E-2
7.746E-2
2.233E-1
 1 18
11 int:CEP83 CEP83 interactions 5.637E-3 1.772E-2
7.746E-2
2.480E-1
 1 20
12 int:HDGFL3 HDGFL3 interactions 5.637E-3 1.772E-2
7.746E-2
2.480E-1
 1 20
13 int:SAR1B SAR1B interactions 5.637E-3 1.772E-2
7.746E-2
2.480E-1
 1 20
14 int:GPALPP1 GPALPP1 interactions 5.637E-3 1.772E-2
7.746E-2
2.480E-1
 1 20
15 int:SNTB1 SNTB1 interactions 6.199E-3 1.818E-2
7.951E-2
2.728E-1
 1 22
16 int:SERPINB8 SERPINB8 interactions 7.603E-3 2.091E-2
9.143E-2
3.346E-1
 1 27
17 int:RNF130 RNF130 interactions 8.726E-3 2.258E-2
9.876E-2
3.839E-1
 1 31
18 int:UBAP2 UBAP2 interactions 1.041E-2 2.339E-2
1.023E-1
4.579E-1
 1 37
19 int:SKIV2L SKIV2L interactions 1.125E-2 2.339E-2
1.023E-1
4.949E-1
 1 40
20 int:MPP3 MPP3 interactions 1.153E-2 2.339E-2
1.023E-1
5.072E-1
 1 41
21 int:HDGFL2 HDGFL2 interactions 1.209E-2 2.339E-2
1.023E-1
5.318E-1
 1 43
22 int:LRP8 LRP8 interactions 1.237E-2 2.339E-2
1.023E-1
5.441E-1
 1 44
23 int:SNTB2 SNTB2 interactions 1.237E-2 2.339E-2
1.023E-1
5.441E-1
 1 44
24 int:RABL6 RABL6 interactions 1.349E-2 2.339E-2
1.023E-1
5.933E-1
 1 48
25 int:ANK3 ANK3 interactions 1.349E-2 2.339E-2
1.023E-1
5.933E-1
 1 48
26 int:DLG2 DLG2 interactions 1.488E-2 2.339E-2
1.023E-1
6.548E-1
 1 53
27 int:DHX16 DHX16 interactions 1.488E-2 2.339E-2
1.023E-1
6.548E-1
 1 53
28 int:REST REST interactions 1.488E-2 2.339E-2
1.023E-1
6.548E-1
 1 53
29 int:DHX38 DHX38 interactions 1.739E-2 2.639E-2
1.154E-1
7.652E-1
 1 62
30 int:MACF1 MACF1 interactions 1.934E-2 2.836E-2
1.240E-1
8.509E-1
 1 69
31 int:KLHL20 KLHL20 interactions 2.073E-2 2.850E-2
1.246E-1
9.121E-1
 1 74
32 int:PATJ PATJ interactions 2.128E-2 2.850E-2
1.246E-1
9.365E-1
 1 76
33 int:LRP2 LRP2 interactions 2.156E-2 2.850E-2
1.246E-1
9.487E-1
 1 77
34 int:MGMT MGMT interactions 2.239E-2 2.850E-2
1.246E-1
9.853E-1
 1 80
35 int:PRKCG PRKCG interactions 2.267E-2 2.850E-2
1.246E-1
9.976E-1
 1 81
36 int:DLG3 DLG3 interactions 2.350E-2 2.873E-2
1.256E-1
1.000E0
 1 84
37 int:SLC9A3R1 SLC9A3R1 interactions 2.931E-2 3.485E-2
1.524E-1
1.000E0
 1 105
38 int:DLG1 DLG1 interactions 3.069E-2 3.493E-2
1.528E-1
1.000E0
 1 110
39 int:ERBIN ERBIN interactions 3.096E-2 3.493E-2
1.528E-1
1.000E0
 1 111
40 int:PSEN1 PSEN1 interactions 3.261E-2 3.588E-2
1.569E-1
1.000E0
 1 117
41 int:LRP1 LRP1 interactions 3.838E-2 4.119E-2
1.801E-1
1.000E0
 1 138
42 int:MECP2 MECP2 interactions 4.466E-2 4.678E-2
2.046E-1
1.000E0
 1 161
Show 37 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q24.3 2q24.3 2.844E-6 1.138E-5 2.370E-5 1.138E-5 2 19
2 2q24 2q24 1.586E-3 3.172E-3 6.608E-3 6.344E-3 1 11
3 Xp22 Xp22 3.889E-3 4.320E-3 9.001E-3 1.556E-2 1 27
4 17q23.3 17q23.3 4.320E-3 4.320E-3 9.001E-3 1.728E-2 1 30

11: Transcription Factor Binding Site [Display Chart] 4 input genes in category / 54 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1203 Sodium voltage-gated channel alpha subunits genenames.org 1.380E-13 2.760E-13 4.140E-13 2.760E-13 4 9
2 496 Cyclin dependent kinases genenames.org 7.126E-3 7.126E-3 1.069E-2 1.425E-2 1 26

13: Coexpression [Display Chart] 5 input genes in category / 244 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7144 Genes down-regulated in CD8A+ [GeneID=925] splenic dendritic cells: wildtype versus IFNB1 [GeneID=3456] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 4.733E-2
2.876E-1
1.766E-1
 2 199
2 M1481 Genes down-regulated in GH3 cells (pituitary cancer) after treatment with LIF [GeneID=3976]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.512E-3 4.733E-2
2.876E-1
3.689E-1
 1 7
3 M1676 Genes whose expression negatively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.290E-3 4.733E-2
2.876E-1
5.586E-1
 2 356
4 M1047 Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing inv(16) translocation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.185E-3 4.733E-2
2.876E-1
7.772E-1
 2 421
5 17325667-Table1a Human Stomach Mahadevan07 20genes OverExpressedGIST-RvsGIST-S GeneSigDB 3.669E-3 4.733E-2
2.876E-1
8.952E-1
 1 17
6 M2440 Genes up-regulated during neuronal differentiation of SH-SY5Y cells (neuroblastoma) in response to stimulation by tretinoin (all-trans retinoic acid, ATRA) [PubChem=444795] and BDNF [GeneID=627]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.884E-3 4.733E-2
2.876E-1
9.477E-1
 1 18
7 15374961-TableS2 Human Brain Freije04 595genes GeneSigDB 4.020E-3 4.733E-2
2.876E-1
9.809E-1
 2 474
8 M18876 Top genes up-regulated in the GIST (gastrointestinal stromal tumor) cell line resistant to imatinib [PubChem=5291] compared to the parental cell line sensitive to the drug. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.961E-3 4.733E-2
2.876E-1
1.000E0
 1 23
9 M14487 Genes directly up-regulated by CD44 [GeneID=960] stimulation of B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.822E-3 4.733E-2
2.876E-1
1.000E0
 1 27
10 12446012-Table3 Mouse Immune Carmody02 40genes GeneSigDB 7.112E-3 4.733E-2
2.876E-1
1.000E0
 1 33
11 19749798-TableS3 Human Lung Olaussen09 58genes GeneSigDB 8.186E-3 4.733E-2
2.876E-1
1.000E0
 1 38
12 M4519 Neurologically relevant transcripts with highest abundance fold range in brain tissue among mouse strains. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.615E-3 4.733E-2
2.876E-1
1.000E0
 1 40
13 M1802 Genes down-regulated in ex-vivo colonic tissue after treatment with IL22 [GeneID=50616]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.044E-3 4.733E-2
2.876E-1
1.000E0
 1 42
14 M17794 Down-regulated genes associated with poor survival prognosis of patients with metastatic neuroblastoma that lack MYCN [GeneID=4613] amplification. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.902E-3 4.733E-2
2.876E-1
1.000E0
 1 46
15 M8645 Genes up-regulated in the nucleus accumbens (a major reward center in brain) 2 weeks after induction of deltaFosB, a FOSB [GeneID=2354] splice variant. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.033E-2 4.733E-2
2.876E-1
1.000E0
 1 48
16 17068154-Table3 Human Leukemia Dijkman07 63genes GeneSigDB 1.033E-2 4.733E-2
2.876E-1
1.000E0
 1 48
17 M3274 Top up-regulated marker genes for medulloblastoma classification: desmoplastic vs classic morphology. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.333E-2 4.733E-2
2.876E-1
1.000E0
 1 62
18 M999 Genes down-regulated in hematopoietic progenitor cells (HPC) of T lymphocyte and NK (natural killer) lineage. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.354E-2 4.733E-2
2.876E-1
1.000E0
 1 63
19 18537973-SuppTable1a Human Lymphoma Miyazaki08 121genes GeneSigDB 1.440E-2 4.733E-2
2.876E-1
1.000E0
 1 67
20 18787207-Table1 Mouse Viral Craft08 83genes GeneSigDB 1.589E-2 4.733E-2
2.876E-1
1.000E0
 1 74
21 M1956 Genes with intermediate-CpG-density promoters (ICP) bearing the tri-methylation mark at H3K27 (H3K27me3) in MCV6 cells (embryonic fibroblasts trapped in a differentiated state). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.589E-2 4.733E-2
2.876E-1
1.000E0
 1 74
22 M18559 Genes up-rgulated in CD34+ [GeneID=947] hematopoetic cells by expression of NUP98-HOXA9 fusion [GeneID=4928;3205] off a retroviral vector at 6h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.824E-2 4.733E-2
2.876E-1
1.000E0
 1 85
23 19286929-SuppTable2h Mouse Lung Rangasamy09 98genes GeneSigDB 1.824E-2 4.733E-2
2.876E-1
1.000E0
 1 85
24 18308945-Table1 Human StemCell Huang08 100genes GeneSigDB 1.930E-2 4.733E-2
2.876E-1
1.000E0
 1 90
25 M2154 Genes down-regulated in MCF7 cells (breast cancer) at 6 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.951E-2 4.733E-2
2.876E-1
1.000E0
 1 91
26 M14698 Genes up-regulated in the common lymphoid progenitor (CLP, defined as CD34+CD38-CD7+ [GeneID=947;952;924]) compared to a multipotent cord blood cell (defined as CD34+CD38+CD7-). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.015E-2 4.733E-2
2.876E-1
1.000E0
 1 94
27 12594241-Table2 Human Lymphoma deVos03 104genes GeneSigDB 2.100E-2 4.733E-2
2.876E-1
1.000E0
 1 98
28 20032505-TableS8 Human Leukemia Stam09 150genes Figure6 GeneSigDB 2.121E-2 4.733E-2
2.876E-1
1.000E0
 1 99
29 20032505-TableS7 Human Leukemia Stam09 150genes Figure5 GeneSigDB 2.121E-2 4.733E-2
2.876E-1
1.000E0
 1 99
30 19749798-TableS2 Human Lung Olaussen09 174genes GeneSigDB 2.376E-2 4.733E-2
2.876E-1
1.000E0
 1 111
31 M6677 Genes down-regulated in bone marrow-derived macrophages at 180 min of stimulation with IL10 [GeneID=3486] and LPS: wildtype versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.440E-2 4.733E-2
2.876E-1
1.000E0
 1 114
32 M8936 Genes down-regulated in T reg: wildtype versus HDAC9 [GeneID=9734] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.461E-2 4.733E-2
2.876E-1
1.000E0
 1 115
33 16818636-TableS1 Human Leukemia Takeda06 172genes GeneSigDB 2.588E-2 4.733E-2
2.876E-1
1.000E0
 1 121
34 16707426-SuppTable2 Human Prostate Zhang06 128genes GeneSigDB 2.609E-2 4.733E-2
2.876E-1
1.000E0
 1 122
35 M481 Genes up-regulated in CD4 [GeneID=920] T cells from healthy donors: activated by anti-CD3 and anti-CD28 versus nitric oxide [PubChem=145068] treatment. MSigDB C7: Immunologic Signatures (v6.0) 2.609E-2 4.733E-2
2.876E-1
1.000E0
 1 122
36 19797726-SuppTable1a Human Lymphoma VanLoo09 135genes GeneSigDB 2.672E-2 4.733E-2
2.876E-1
1.000E0
 1 125
37 M1896 Genes down-regulated in dendritic cells (12 days): control versus 25-hydroxyvitamin D3 [PubChem=1593]. MSigDB C7: Immunologic Signatures (v6.0) 2.736E-2 4.733E-2
2.876E-1
1.000E0
 1 128
38 M6759 Genes down-regulated in splenic 33D1+ dendritic cells versus CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.757E-2 4.733E-2
2.876E-1
1.000E0
 1 129
39 M1894 Genes up-regulated in dendritic cells (5 days): control versus 25-hydroxyvitamin D3 [PubChem=1593]. MSigDB C7: Immunologic Signatures (v6.0) 2.757E-2 4.733E-2
2.876E-1
1.000E0
 1 129
40 M2906 Genes up-regulated in skin from BALB/c mice after injection of: control versus Trypanosoma cruzi (strain Y). MSigDB C7: Immunologic Signatures (v6.0) 2.863E-2 4.733E-2
2.876E-1
1.000E0
 1 134
41 M2798 Genes up-regulated in retina cells from NRL [Gene ID=4901] knockout mice. MSigDB C6: Oncogenic Signatures (v6.0) 2.905E-2 4.733E-2
2.876E-1
1.000E0
 1 136
42 M8904 Genes up-regulated in pro-B cells versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.989E-2 4.733E-2
2.876E-1
1.000E0
 1 140
43 M2748 Genes up-regulated in MCF10A cells (breast cancer) upon knockdown of BRCA1 [Gene ID=672] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 2.989E-2 4.733E-2
2.876E-1
1.000E0
 1 140
44 M463 Genes down-regulated in CD4 [GeneID=920] T cells: control versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 2.989E-2 4.733E-2
2.876E-1
1.000E0
 1 140
45 M422 Genes down-regulated in dendritic cells: immature versus mature inhibitory treated by prostaglandin E2 [PubChem=5280360]. MSigDB C7: Immunologic Signatures (v6.0) 3.010E-2 4.733E-2
2.876E-1
1.000E0
 1 141
46 M2774 Genes up-regulated in DAOY cells (medulloblastoma) upon knockdown of ALK [Gene ID=238] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 3.032E-2 4.733E-2
2.876E-1
1.000E0
 1 142
47 M2892 Genes up-regulated in epithelial kidney cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.053E-2 4.733E-2
2.876E-1
1.000E0
 1 143
48 M2875 Genes up-regulated in four lineages of epithelial cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.053E-2 4.733E-2
2.876E-1
1.000E0
 1 143
49 M2506 Genes up-regulated in the neural crest stem cells (NCS), defined as p75+/HNK1+ [GeneID=4804;27087]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.116E-2 4.733E-2
2.876E-1
1.000E0
 1 146
50 M6708 Genes down-regulated in endothelial cells: untreated versus exposed to E. burgdoferi. MSigDB C7: Immunologic Signatures (v6.0) 3.116E-2 4.733E-2
2.876E-1
1.000E0
 1 146
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 529 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkF Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkF Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.068E-7 1.094E-4 7.493E-4 1.094E-4 3 61
2 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.835E-6 8.423E-4 5.769E-3 2.558E-3 3 173
3 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Overall Top 200 Genes BrainMap 6.307E-6 8.423E-4 5.769E-3 3.337E-3 3 189
4 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 7.143E-6 8.423E-4 5.769E-3 3.779E-3 3 197
5 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Subtype Neuron.excitatory.Slc17a6.Rora Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Subtype Neuron.excitatory.Slc17a6.Rora Top 200 Genes BrainMap 1.530E-5 8.423E-4 5.769E-3 8.096E-3 3 254
6 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Top 200 BrainMap 1.530E-5 8.423E-4 5.769E-3 8.096E-3 3 254
7 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkG Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkG Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.548E-5 8.423E-4 5.769E-3 8.191E-3 3 255
8 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkA Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkA Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.071E-5 8.423E-4 5.769E-3 1.095E-2 3 281
9 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.076E-5 8.423E-4 5.769E-3 1.098E-2 2 32
10 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkD Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkD Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.183E-5 8.423E-4 5.769E-3 1.155E-2 3 286
11 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap 2.543E-5 8.423E-4 5.769E-3 1.345E-2 3 301
12 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Overall Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Overall Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.787E-5 8.423E-4 5.769E-3 1.474E-2 2 37
13 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkI Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkI Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.804E-5 8.423E-4 5.769E-3 1.483E-2 3 311
14 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap 2.831E-5 8.423E-4 5.769E-3 1.498E-2 3 312
15 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Gad1,Gad2 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Gad1,Gad2 Top 200 Genes 2.858E-5 8.423E-4 5.769E-3 1.512E-2 3 313
16 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkF Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkF Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 2.858E-5 8.423E-4 5.769E-3 1.512E-2 3 313
17 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.025E-5 8.423E-4 5.769E-3 1.600E-2 3 319
18 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkC Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkC Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.025E-5 8.423E-4 5.769E-3 1.600E-2 3 319
19 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkB Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkB Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.025E-5 8.423E-4 5.769E-3 1.600E-2 3 319
20 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 PosteriorCortex Top 200 Genes BrainMap 3.258E-5 8.616E-4 5.901E-3 1.723E-2 3 327
21 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hGaba Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hGaba Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 3.956E-5 9.952E-4 6.816E-3 2.093E-2 3 349
22 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hNbGaba Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hNbGaba Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.163E-5 9.952E-4 6.816E-3 2.202E-2 3 355
23 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkG Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkG Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 4.327E-5 9.952E-4 6.816E-3 2.289E-2 2 46
24 BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5 FrontalCortex Top 200 Genes BrainMap 4.597E-5 1.013E-3 6.940E-3 2.432E-2 3 367
25 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkA Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkA Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 5.119E-5 1.083E-3 7.419E-3 2.708E-2 2 50
26 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkD Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkD Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 5.757E-5 1.171E-3 8.022E-3 3.045E-2 2 53
27 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkI Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkI Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 5.978E-5 1.171E-3 8.022E-3 3.162E-2 2 54
28 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 6.903E-5 1.304E-3 8.932E-3 3.652E-2 2 58
29 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkC Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkC Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 7.390E-5 1.348E-3 9.233E-3 3.909E-2 2 60
30 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 7.839E-5 1.382E-3 9.468E-3 4.147E-2 3 439
31 BM Top 100 - thalamus BM Top 100 - thalamus Body Map 8.152E-5 1.391E-3 9.528E-3 4.312E-2 2 63
32 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkB Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkB Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 8.680E-5 1.435E-3 9.828E-3 4.592E-2 2 65
33 BM Top 100 - vestibular nuclei superior BM Top 100 - vestibular nuclei superior Body Map 9.787E-5 1.569E-3 1.075E-2
5.177E-2
 2 69
34 BM Top 100 - midbrain BM Top 100 - midbrain Body Map 1.066E-4 1.610E-3 1.103E-2
5.639E-2
 2 72
35 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hNbGaba Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hNbGaba Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.066E-4 1.610E-3 1.103E-2
5.639E-2
 2 72
36 BM Top 100 - cerebral cortex BM Top 100 - cerebral cortex Body Map 1.096E-4 1.610E-3 1.103E-2
5.797E-2
 2 73
37 BM Top 100 - occipital lobe BM Top 100 - occipital lobe Body Map 1.126E-4 1.610E-3 1.103E-2
5.958E-2
 2 74
38 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hGaba Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Subtype hGaba Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.157E-4 1.611E-3 1.103E-2
6.121E-2
 2 75
39 BM Top 100 - parietal lobe BM Top 100 - parietal lobe Body Map 1.188E-4 1.612E-3 1.104E-2
6.285E-2
 2 76
40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 2.492E-4 3.295E-3 2.257E-2
1.318E-1
 2 110
41 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k1 500 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.216E-4 4.150E-3 2.842E-2
1.702E-1
 2 125
42 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/5/2 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Oligodendroglioma/5/2 TCGA-Brain 5.197E-4 5.895E-3 4.037E-2
2.749E-1
 2 159
43 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Top 200 BrainMap 6.007E-4 5.895E-3 4.037E-2
3.178E-1
 2 171
44 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Overall Top 200 Genes BrainMap 6.007E-4 5.895E-3 4.037E-2
3.178E-1
 2 171
45 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg10 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr/Cspg10 BrainMap 6.652E-4 5.895E-3 4.037E-2
3.519E-1
 2 180
46 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 6.800E-4 5.895E-3 4.037E-2
3.597E-1
 2 182
47 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 6.875E-4 5.895E-3 4.037E-2
3.637E-1
 2 183
48 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOMTN Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 6.875E-4 5.895E-3 4.037E-2
3.637E-1
 2 183
49 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 7.025E-4 5.895E-3 4.037E-2
3.716E-1
 2 185
50 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hOPC Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 7.025E-4 5.895E-3 4.037E-2
3.716E-1
 2 185
Show 45 more annotations

15: Computational [Display Chart] 3 input genes in category / 18 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 218 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-628-5p:PITA hsa-miR-628-5p:PITA TOP PITA 1.043E-7 2.273E-5 1.356E-4 2.273E-5 3 159
2 hsa-miR-223:PITA hsa-miR-223:PITA TOP PITA 3.212E-7 2.926E-5 1.745E-4 7.002E-5 3 231
3 hsa-miR-1207-3p:PITA hsa-miR-1207-3p:PITA TOP PITA 5.485E-7 2.926E-5 1.745E-4 1.196E-4 3 276
4 hsa-miR-223-3p:TargetScan hsa-miR-223-3p TargetScan 5.851E-7 2.926E-5 1.745E-4 1.276E-4 3 282
5 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 7.479E-7 2.926E-5 1.745E-4 1.630E-4 3 306
6 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 1.008E-6 2.926E-5 1.745E-4 2.198E-4 3 338
7 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 1.008E-6 2.926E-5 1.745E-4 2.198E-4 3 338
8 hsa-miR-132-3p:TargetScan hsa-miR-132-3p TargetScan 1.208E-6 2.926E-5 1.745E-4 2.634E-4 3 359
9 hsa-miR-212-3p:TargetScan hsa-miR-212-3p TargetScan 1.208E-6 2.926E-5 1.745E-4 2.634E-4 3 359
10 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 1.609E-6 3.189E-5 1.902E-4 3.508E-4 3 395
11 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 1.609E-6 3.189E-5 1.902E-4 3.508E-4 3 395
12 hsa-miR-1289:PITA hsa-miR-1289:PITA TOP PITA 1.817E-5 3.300E-4 1.968E-3 3.960E-3 2 98
13 hsa-miR-1267:PITA hsa-miR-1267:PITA TOP PITA 4.380E-5 7.027E-4 4.191E-3 9.548E-3 2 152
14 hsa-let-7i*:mirSVR highEffct hsa-let-7i*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.555E-5 7.027E-4 4.191E-3 9.929E-3 2 155
15 hsa-miR-660:PITA hsa-miR-660:PITA TOP PITA 5.288E-5 7.027E-4 4.191E-3 1.153E-2 2 167
16 hsa-miR-502-3p:PITA hsa-miR-502-3p:PITA TOP PITA 5.415E-5 7.027E-4 4.191E-3 1.181E-2 2 169
17 hsa-miR-501-3p:PITA hsa-miR-501-3p:PITA TOP PITA 5.480E-5 7.027E-4 4.191E-3 1.195E-2 2 170
18 hsa-miR-514:PITA hsa-miR-514:PITA TOP PITA 5.807E-5 7.033E-4 4.194E-3 1.266E-2 2 175
19 hsa-miR-556-3p:PITA hsa-miR-556-3p:PITA TOP PITA 6.845E-5 7.540E-4 4.497E-3 1.492E-2 2 190
20 hsa-miR-542-3p:PITA hsa-miR-542-3p:PITA TOP PITA 6.918E-5 7.540E-4 4.497E-3 1.508E-2 2 191
21 hsa-miR-1826:PITA hsa-miR-1826:PITA TOP PITA 7.359E-5 7.639E-4 4.556E-3 1.604E-2 2 197
22 hsa-miR-499-5p:PITA hsa-miR-499-5p:PITA TOP PITA 9.513E-5 9.427E-4 5.622E-3 2.074E-2 2 224
23 hsa-miR-1246:PITA hsa-miR-1246:PITA TOP PITA 1.029E-4 9.755E-4 5.818E-3 2.244E-2 2 233
24 hsa-miR-371-5p:PITA hsa-miR-371-5p:PITA TOP PITA 1.119E-4 1.017E-3 6.064E-3 2.440E-2 2 243
25 hsa-miR-1244:PITA hsa-miR-1244:PITA TOP PITA 1.301E-4 1.107E-3 6.603E-3 2.836E-2 2 262
26 hsa-miR-633:PITA hsa-miR-633:PITA TOP PITA 1.341E-4 1.107E-3 6.603E-3 2.923E-2 2 266
27 hsa-miR-298:PITA hsa-miR-298:PITA TOP PITA 1.371E-4 1.107E-3 6.603E-3 2.989E-2 2 269
28 hsa-miR-371a-5p:TargetScan hsa-miR-371a-5p TargetScan 1.433E-4 1.116E-3 6.654E-3 3.124E-2 2 275
29 hsa-miR-509-3-5p:PITA hsa-miR-509-3-5p:PITA TOP PITA 1.637E-4 1.190E-3 7.096E-3 3.569E-2 2 294
30 hsa-miR-509-5p:PITA hsa-miR-509-5p:PITA TOP PITA 1.637E-4 1.190E-3 7.096E-3 3.569E-2 2 294
31 hsa-miR-557:PITA hsa-miR-557:PITA TOP PITA 1.750E-4 1.192E-3 7.112E-3 3.816E-2 2 304
32 hsa-miR-507:PITA hsa-miR-507:PITA TOP PITA 1.750E-4 1.192E-3 7.112E-3 3.816E-2 2 304
33 hsa-miR-139-5p:TargetScan hsa-miR-139-5p TargetScan 1.879E-4 1.235E-3 7.368E-3 4.096E-2 2 315
34 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 1.927E-4 1.235E-3 7.368E-3 4.200E-2 2 319
35 hsa-miR-140-3p:PITA hsa-miR-140-3p:PITA TOP PITA 2.049E-4 1.276E-3 7.612E-3 4.467E-2 2 329
36 hsa-miR-499-3p:PITA hsa-miR-499-3p:PITA TOP PITA 2.253E-4 1.364E-3 8.135E-3 4.911E-2 2 345
37 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 2.358E-4 1.389E-3 8.286E-3
5.140E-2
 2 353
38 hsa-miR-183-5p.1:TargetScan hsa-miR-183-5p.1 TargetScan 2.562E-4 1.470E-3 8.765E-3
5.585E-2
 2 368
39 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 3.040E-4 1.699E-3 1.013E-2
6.627E-2
 2 401
40 hsa-miR-140-3p.1:TargetScan hsa-miR-140-3p.1 TargetScan 4.348E-4 2.369E-3 1.413E-2
9.478E-2
 2 480
41 hsa-miR-518b:Functional MTI Functional MTI miRTarbase 9.686E-4 5.150E-3 3.072E-2
2.112E-1
 1 14
42 hsa-miR-933:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.453E-3 7.540E-3 4.497E-2
3.167E-1
 1 21
43 hsa-miR-4783-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.075E-3 1.052E-2
6.273E-2
4.523E-1
 1 30
44 hsa-miR-1284:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.387E-3 1.678E-2
1.001E-1
7.383E-1
 1 49
45 hsa-miR-4509:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.939E-3 1.908E-2
1.138E-1
8.587E-1
 1 57
46 GTGTCAA,MIR-514:MSigDB GTGTCAA,MIR-514:MSigDB MSigDB 4.077E-3 1.932E-2
1.152E-1
8.888E-1
 1 59
47 hsa-miR-4744:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.211E-2
1.319E-1
1.000E0
 1 69
48 ATGTCAC,MIR-489:MSigDB ATGTCAC,MIR-489:MSigDB MSigDB 5.801E-3 2.620E-2
1.563E-1
1.000E0
 1 84
49 hsa-miR-877-5p:TargetScan hsa-miR-877-5p TargetScan 6.145E-3 2.620E-2
1.563E-1
1.000E0
 1 89
50 AACTGAC,MIR-223:MSigDB AACTGAC,MIR-223:MSigDB MSigDB 6.420E-3 2.620E-2
1.563E-1
1.000E0
 1 93
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 631 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 DB00909 Zonisamide Drug Bank 1.049E-12 6.620E-10 4.651E-9 6.620E-10 4 17
2 ctd:C475726 APETx1, Anthopleura elegantissima CTD 1.007E-10 3.177E-8 2.232E-7 6.354E-8 3 6
3 ctd:D012604 Scorpion Venoms CTD 4.105E-9 8.634E-7 6.066E-6 2.590E-6 3 18
4 ctd:C502265 mu-conotoxin KIIIA, Conus kinoshitai CTD 3.834E-8 4.927E-6 3.461E-5 2.419E-5 2 2
5 CID000002337 benzocaine Stitch 3.904E-8 4.927E-6 3.461E-5 2.463E-5 3 37
6 ctd:C561228 N-(2-methyl-3-(4-(4-(4-(trifluoromethoxy)benzyloxy)piperidin-1-yl)-1,3,5-triazin-2-ylamino)phenyl)acetamide CTD 1.150E-7 1.209E-5 8.497E-5 7.257E-5 2 3
7 CID000037165 saxitoxin Stitch 2.191E-7 1.612E-5 1.133E-4 1.382E-4 3 65
8 DB00818 Propofol Drug Bank 2.300E-7 1.612E-5 1.133E-4 1.451E-4 2 4
9 DB06716 Fospropofol Drug Bank 2.300E-7 1.612E-5 1.133E-4 1.451E-4 2 4
10 ctd:C044267 fenpropathrin CTD 5.749E-7 3.627E-5 2.548E-4 3.627E-4 2 6
11 CID011051569 fluorocyclobutane Stitch 8.047E-7 4.616E-5 3.243E-4 5.078E-4 2 7
12 ctd:C489827 2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate CTD 1.073E-6 5.642E-5 3.963E-4 6.770E-4 2 8
13 CID000003878 lamotrigine Stitch 1.267E-6 6.149E-5 4.320E-4 7.994E-4 3 116
14 ctd:C017180 decamethrin CTD 2.641E-6 1.190E-4 8.361E-4 1.666E-3 3 148
15 CID005317623 20(S)-Propanaxidiol Stitch 2.987E-6 1.257E-4 8.829E-4 1.885E-3 2 13
16 CID000008914 nonanol Stitch 4.021E-6 1.586E-4 1.114E-3 2.537E-3 2 15
17 CID000002554 carbamazepine Stitch 4.679E-6 1.724E-4 1.211E-3 2.952E-3 3 179
18 CID000005657 NSC7524 Stitch 4.918E-6 1.724E-4 1.211E-3 3.103E-3 3 182
19 ctd:C100442 PD 150606 CTD 5.207E-6 1.729E-4 1.215E-3 3.286E-3 2 17
20 CID000071249 diprafenone Stitch 6.546E-6 1.967E-4 1.382E-3 4.130E-3 2 19
21 CID005288877 AC1NRC8M Stitch 6.546E-6 1.967E-4 1.382E-3 4.130E-3 2 19
22 CID000001775 phenytoin Stitch 8.572E-6 2.459E-4 1.727E-3 5.409E-3 3 219
23 CID000079091 1-chloro-1,2,2-trifluorocyclobutane Stitch 1.056E-5 2.897E-4 2.035E-3 6.664E-3 2 24
24 CID000024365 Multicide Stitch 1.148E-5 2.897E-4 2.035E-3 7.243E-3 2 25
25 CID005322157 AC1NT1AF Stitch 1.148E-5 2.897E-4 2.035E-3 7.243E-3 2 25
26 CID000004853 Pirmenolum Stitch 1.243E-5 2.922E-4 2.052E-3 7.845E-3 2 26
27 CID006437089 PbTx-1 Stitch 1.343E-5 2.922E-4 2.052E-3 8.472E-3 2 27
28 CID000004450 nefopam Stitch 1.343E-5 2.922E-4 2.052E-3 8.472E-3 2 27
29 CID000031958 AC1L1MOZ Stitch 1.343E-5 2.922E-4 2.052E-3 8.472E-3 2 27
30 CID000007175 paraben Stitch 1.446E-5 3.041E-4 2.136E-3 9.123E-3 2 28
31 ctd:C052570 cyfluthrin CTD 1.553E-5 3.161E-4 2.221E-3 9.798E-3 2 29
32 CID000038945 tocainide Stitch 1.664E-5 3.280E-4 2.305E-3 1.050E-2 2 30
33 CID000005658 NSC93767 Stitch 1.897E-5 3.626E-4 2.548E-3 1.197E-2 2 32
34 CID000107927 5-hydroxypropafenone Stitch 2.145E-5 3.980E-4 2.796E-3 1.353E-2 2 34
35 CID000009643 1,2-dichlorohexafluorocyclobutane Stitch 2.545E-5 4.462E-4 3.134E-3 1.606E-2 2 37
36 CID000060803 sipatrigine Stitch 2.545E-5 4.462E-4 3.134E-3 1.606E-2 2 37
37 CID000002218 aprindine Stitch 2.687E-5 4.582E-4 3.219E-3 1.695E-2 2 38
38 CID000071273 S-ropivacaine Stitch 2.980E-5 4.822E-4 3.388E-3 1.881E-2 2 40
39 ctd:D013779 Tetrodotoxin CTD 2.980E-5 4.822E-4 3.388E-3 1.881E-2 2 40
40 CID011708451 2 IMA Stitch 3.133E-5 4.942E-4 3.472E-3 1.977E-2 2 41
41 CID000004820 pilsicainide Stitch 3.953E-5 5.938E-4 4.172E-3 2.494E-2 2 46
42 CID000005620 spiradoline Stitch 3.953E-5 5.938E-4 4.172E-3 2.494E-2 2 46
43 CID000107720 indoxacarb Stitch 4.490E-5 6.589E-4 4.629E-3 2.833E-2 2 49
44 ctd:D010672 Phenytoin CTD 4.890E-5 7.012E-4 4.926E-3 3.085E-2 3 392
45 CID005366189 AC1NSN3X Stitch 5.461E-5 7.491E-4 5.263E-3 3.446E-2 2 54
46 CID000141233 sodiosodium Stitch 5.461E-5 7.491E-4 5.263E-3 3.446E-2 2 54
47 CID000005546 triamterene Stitch 6.306E-5 8.352E-4 5.867E-3 3.979E-2 2 58
48 CID000020382 tetradotoxin Stitch 6.353E-5 8.352E-4 5.867E-3 4.009E-2 3 428
49 CID000005734 zonisamide Stitch 7.212E-5 9.101E-4 6.394E-3 4.550E-2 2 62
50 CID000446091 NA-1 Stitch 7.212E-5 9.101E-4 6.394E-3 4.550E-2 2 62
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 335 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0085584 Encephalopathies DisGeNET Curated 9.266E-8 1.434E-5 9.170E-5 3.104E-5 4 191
2 C3887898 Infantile Spasm DisGeNET Curated 1.092E-7 1.434E-5 9.170E-5 3.659E-5 3 37
3 C4021759 Generalized myoclonic seizures DisGeNET Curated 1.285E-7 1.434E-5 9.170E-5 4.303E-5 3 39
4 C1848924 Infantile onset DisGeNET Curated 2.243E-7 1.477E-5 9.443E-5 7.513E-5 4 238
5 C0270844 Seizures, Tonic DisGeNET BeFree 2.285E-7 1.477E-5 9.443E-5 7.654E-5 2 3
6 C0006111 Brain Diseases DisGeNET Curated 2.646E-7 1.477E-5 9.443E-5 8.863E-5 4 248
7 C1096063 Drug Resistant Epilepsy DisGeNET BeFree 3.890E-7 1.528E-5 9.767E-5 1.303E-4 3 56
8 C0543888 Epileptic encephalopathy DisGeNET Curated 4.106E-7 1.528E-5 9.767E-5 1.375E-4 3 57
9 C0037769 West Syndrome DisGeNET Curated 4.106E-7 1.528E-5 9.767E-5 1.375E-4 3 57
10 C0014550 Epilepsies, Myoclonic DisGeNET Curated 4.561E-7 1.528E-5 9.767E-5 1.528E-4 3 59
11 C0494475 Tonic - clonic seizures DisGeNET Curated 6.716E-7 2.045E-5 1.307E-4 2.250E-4 3 67
12 OMIN:604233 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS; GEFS+ OMIM 7.614E-7 2.064E-5 1.319E-4 2.551E-4 2 5
13 C0751778 Myoclonic Epilepsies, Progressive DisGeNET Curated 8.009E-7 2.064E-5 1.319E-4 2.683E-4 3 71
14 C4023511 Obtundation status DisGeNET Curated 1.598E-6 3.570E-5 2.282E-4 5.355E-4 2 7
15 C1858672 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 1 DisGeNET Curated 1.598E-6 3.570E-5 2.282E-4 5.355E-4 2 7
16 C0151611 Electroencephalogram abnormal DisGeNET Curated 2.471E-6 4.830E-5 3.088E-4 8.278E-4 3 103
17 C0027066 Myoclonus DisGeNET Curated 2.695E-6 4.830E-5 3.088E-4 9.027E-4 3 106
18 C3502809 Generalized Epilepsy with Febrile Seizures Plus DisGeNET BeFree 2.740E-6 4.830E-5 3.088E-4 9.178E-4 2 9
19 C0752323 Focal Clonic Seizures DisGeNET Curated 2.740E-6 4.830E-5 3.088E-4 9.178E-4 2 9
20 C0036857 Severe mental retardation (I.Q. 20-34) DisGeNET Curated 9.137E-6 1.530E-4 9.784E-4 3.061E-3 3 159
21 C1866862 Highly variable severity DisGeNET Curated 1.040E-5 1.583E-4 1.012E-3 3.484E-3 3 166
22 C1861403 Variable expressivity DisGeNET Curated 1.040E-5 1.583E-4 1.012E-3 3.484E-3 3 166
23 C0391957 idiopathic epilepsy DisGeNET BeFree 1.444E-5 2.103E-4 1.344E-3 4.837E-3 2 20
24 C0393706 Early infantile epileptic encephalopathy with suppression bursts DisGeNET Curated 1.922E-5 2.683E-4 1.715E-3 6.439E-3 2 23
25 C0751122 Infantile Severe Myoclonic Epilepsy DisGeNET Curated 2.278E-5 3.053E-4 1.952E-3 7.633E-3 2 25
26 C0751495 Seizures, Focal DisGeNET Curated 2.665E-5 3.434E-4 2.195E-3 8.928E-3 2 27
27 C0856975 Autistic behavior DisGeNET Curated 4.256E-5 5.281E-4 3.376E-3 1.426E-2 2 34
28 C0014547 Epilepsies, Partial DisGeNET Curated 5.331E-5 6.158E-4 3.937E-3 1.786E-2 2 38
29 C0014548 Epilepsy, Generalized DisGeNET Curated 5.331E-5 6.158E-4 3.937E-3 1.786E-2 2 38
30 C0270850 Idiopathic generalized epilepsy DisGeNET Curated 1.124E-4 1.183E-3 7.561E-3 3.764E-2 2 55
31 C0349506 Photosensitivity of skin DisGeNET Curated 1.124E-4 1.183E-3 7.561E-3 3.764E-2 2 55
32 C1720983 Channelopathies DisGeNET BeFree 1.165E-4 1.183E-3 7.561E-3 3.903E-2 2 56
33 C0009952 Febrile Convulsions DisGeNET Curated 1.165E-4 1.183E-3 7.561E-3 3.903E-2 2 56
34 C0423224 Sunken eyes DisGeNET Curated 1.476E-4 1.413E-3 9.034E-3 4.946E-2 2 63
35 C0014306 Enophthalmos DisGeNET Curated 1.476E-4 1.413E-3 9.034E-3 4.946E-2 2 63
36 C1510586 Autism Spectrum Disorders DisGeNET Curated 1.858E-4 1.436E-3 9.178E-3
6.224E-2
 3 436
37 C0026826 Muscle Hypertonia DisGeNET Curated 2.885E-4 1.436E-3 9.178E-3
9.664E-2
 2 88
38 OMIN:607745 CONVULSIONS, BENIGN FAMILIAL INFANTILE, 3; BFIC3 OMIM 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
39 OMIN:168300 PARAMYOTONIA CONGENITA OF VON EULENBURG; PMC OMIM 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
40 OMIN:609634 MIGRAINE, FAMILIAL HEMIPLEGIC, 3; FHM3 OMIM 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
41 C4023515 Dialeptic seizures DisGeNET Curated 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
42 C0149886 Seizure, Febrile, Simple DisGeNET BeFree 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
43 C0751359 Percussion Myotonia DisGeNET Curated 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
44 cv:C3150987 Early infantile epileptic encephalopathy 11 Clinical Variations 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
45 OMIN:608390 MYOTONIA, POTASSIUM-AGGRAVATED OMIM 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
46 C1839333 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 2 DisGeNET Curated 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
47 cv:CN128785 Angelman syndrome-like Clinical Variations 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
48 C2750061 Hypokalemic Periodic Paralysis, Type 2 DisGeNET Curated 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
49 C4023179 Paradoxical myotonia DisGeNET Curated 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
50 cv:C1858673 Generalized epilepsy with febrile seizures plus, type 2 Clinical Variations 3.085E-4 1.436E-3 9.178E-3
1.034E-1
 1 1
Show 45 more annotations