Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc90_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 68 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005114 type II transforming growth factor beta receptor binding 1.809E-9 1.230E-7 5.908E-7 1.230E-7 3 8
2 GO:0050431 transforming growth factor beta binding 2.631E-8 8.946E-7 4.297E-6 1.789E-6 3 18
3 GO:0005160 transforming growth factor beta receptor binding 7.511E-7 1.702E-5 8.179E-5 5.107E-5 3 53
4 GO:0005024 transforming growth factor beta-activated receptor activity 5.420E-6 6.375E-5 3.062E-4 3.686E-4 2 10
5 GO:0034713 type I transforming growth factor beta receptor binding 5.420E-6 6.375E-5 3.062E-4 3.686E-4 2 10
6 GO:0019955 cytokine binding 5.625E-6 6.375E-5 3.062E-4 3.825E-4 3 103
7 GO:0019838 growth factor binding 1.477E-5 1.434E-4 6.891E-4 1.004E-3 3 142
8 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 3.316E-5 2.819E-4 1.354E-3 2.255E-3 2 24
9 GO:0005126 cytokine receptor binding 1.229E-4 9.283E-4 4.460E-3 8.355E-3 3 289
10 GO:0004674 protein serine/threonine kinase activity 4.595E-4 3.005E-3 1.444E-2 3.125E-2 3 452
11 GO:0019199 transmembrane receptor protein kinase activity 4.861E-4 3.005E-3 1.444E-2 3.306E-2 2 91
12 GO:0002135 CTP binding 7.501E-4 4.251E-3 2.042E-2
5.101E-2
 1 2
13 GO:0017098 sulfonylurea receptor binding 1.125E-3 5.542E-3 2.662E-2
7.650E-2
 1 3
14 GO:0005025 transforming growth factor beta receptor activity, type I 1.500E-3 5.542E-3 2.662E-2
1.020E-1
 1 4
15 GO:0034714 type III transforming growth factor beta receptor binding 1.500E-3 5.542E-3 2.662E-2
1.020E-1
 1 4
16 GO:0032551 pyrimidine ribonucleoside binding 1.500E-3 5.542E-3 2.662E-2
1.020E-1
 1 4
17 GO:0032564 dATP binding 1.500E-3 5.542E-3 2.662E-2
1.020E-1
 1 4
18 GO:0002134 UTP binding 1.500E-3 5.542E-3 2.662E-2
1.020E-1
 1 4
19 GO:0030911 TPR domain binding 1.874E-3 5.542E-3 2.662E-2
1.275E-1
 1 5
20 GO:0032558 adenyl deoxyribonucleotide binding 1.874E-3 5.542E-3 2.662E-2
1.275E-1
 1 5
21 GO:0051022 Rho GDP-dissociation inhibitor binding 1.874E-3 5.542E-3 2.662E-2
1.275E-1
 1 5
22 GO:0001884 pyrimidine nucleoside binding 1.874E-3 5.542E-3 2.662E-2
1.275E-1
 1 5
23 GO:0032557 pyrimidine ribonucleotide binding 1.874E-3 5.542E-3 2.662E-2
1.275E-1
 1 5
24 GO:0032554 purine deoxyribonucleotide binding 2.249E-3 6.117E-3 2.939E-2
1.529E-1
 1 6
25 GO:0051021 GDP-dissociation inhibitor binding 2.249E-3 6.117E-3 2.939E-2
1.529E-1
 1 6
26 GO:0005534 galactose binding 2.623E-3 6.861E-3 3.296E-2
1.784E-1
 1 7
27 GO:0032552 deoxyribonucleotide binding 2.998E-3 7.549E-3 3.627E-2
2.038E-1
 1 8
28 GO:0098748 endocytic adaptor activity 3.372E-3 7.906E-3 3.798E-2
2.293E-1
 1 9
29 GO:0035615 clathrin adaptor activity 3.372E-3 7.906E-3 3.798E-2
2.293E-1
 1 9
30 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity 3.746E-3 8.216E-3 3.947E-2
2.547E-1
 1 10
31 GO:0030235 nitric-oxide synthase regulator activity 3.746E-3 8.216E-3 3.947E-2
2.547E-1
 1 10
32 GO:0036122 BMP binding 4.120E-3 8.239E-3 3.958E-2
2.801E-1
 1 11
33 GO:0070411 I-SMAD binding 4.120E-3 8.239E-3 3.958E-2
2.801E-1
 1 11
34 GO:0019103 pyrimidine nucleotide binding 4.120E-3 8.239E-3 3.958E-2
2.801E-1
 1 11
35 GO:0048185 activin binding 4.867E-3 9.456E-3 4.543E-2
3.310E-1
 1 13
36 GO:0048156 tau protein binding 5.241E-3 9.899E-3 4.756E-2
3.564E-1
 1 14
37 GO:0023026 MHC class II protein complex binding 5.987E-3 1.100E-2
5.286E-2
4.071E-1
 1 16
38 GO:0023023 MHC protein complex binding 7.107E-3 1.272E-2
6.109E-2
4.832E-1
 1 19
39 GO:0097472 cyclin-dependent protein kinase activity 1.306E-2 2.220E-2
1.066E-1
8.879E-1
 1 35
40 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 1.306E-2 2.220E-2
1.066E-1
8.879E-1
 1 35
41 GO:0005048 signal sequence binding 1.565E-2 2.596E-2
1.247E-1
1.000E0
 1 42
42 GO:0030276 clathrin binding 2.450E-2 3.967E-2
1.906E-1
1.000E0
 1 66
43 GO:0046332 SMAD binding 2.853E-2 4.512E-2
2.168E-1
1.000E0
 1 77
44 GO:0048029 monosaccharide binding 2.963E-2 4.579E-2
2.200E-1
1.000E0
 1 80
Show 39 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 523 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 3.619E-9 7.830E-7 5.354E-6 1.893E-6 4 61
2 GO:0060389 pathway-restricted SMAD protein phosphorylation 4.404E-9 7.830E-7 5.354E-6 2.304E-6 4 64
3 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 5.989E-9 7.830E-7 5.354E-6 3.132E-6 4 69
4 GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus 5.989E-9 7.830E-7 5.354E-6 3.132E-6 4 69
5 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 3.296E-8 2.873E-6 1.965E-5 1.724E-5 4 105
6 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 3.296E-8 2.873E-6 1.965E-5 1.724E-5 4 105
7 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.978E-8 2.972E-6 2.032E-5 2.081E-5 4 110
8 GO:0090288 negative regulation of cellular response to growth factor stimulus 9.089E-8 5.942E-6 4.063E-5 4.754E-5 4 135
9 GO:0070483 detection of hypoxia 1.211E-7 7.038E-6 4.812E-5 6.334E-5 2 2
10 GO:0007179 transforming growth factor beta receptor signaling pathway 3.154E-7 1.650E-5 1.128E-4 1.650E-4 4 184
11 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation 5.947E-7 2.828E-5 1.933E-4 3.110E-4 3 49
12 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 6.689E-7 2.915E-5 1.993E-4 3.498E-4 4 222
13 GO:0071560 cellular response to transforming growth factor beta stimulus 7.706E-7 3.032E-5 2.073E-4 4.030E-4 4 230
14 GO:0071559 response to transforming growth factor beta 8.115E-7 3.032E-5 2.073E-4 4.244E-4 4 233
15 GO:0090287 regulation of cellular response to growth factor stimulus 1.182E-6 3.957E-5 2.705E-4 6.181E-4 4 256
16 GO:0003032 detection of oxygen 1.210E-6 3.957E-5 2.705E-4 6.331E-4 2 5
17 GO:0060485 mesenchyme development 1.336E-6 4.111E-5 2.811E-4 6.988E-4 4 264
18 GO:0010717 regulation of epithelial to mesenchymal transition 1.761E-6 5.117E-5 3.499E-4 9.210E-4 3 70
19 GO:0060840 artery development 3.767E-6 9.907E-5 6.774E-4 1.970E-3 3 90
20 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 3.788E-6 9.907E-5 6.774E-4 1.981E-3 4 343
21 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 5.997E-6 1.462E-4 1.000E-3 3.136E-3 3 105
22 GO:0042307 positive regulation of protein import into nucleus 6.170E-6 1.462E-4 1.000E-3 3.227E-3 3 106
23 GO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation 6.650E-6 1.462E-4 1.000E-3 3.478E-3 2 11
24 GO:1904591 positive regulation of protein import 6.711E-6 1.462E-4 1.000E-3 3.510E-3 3 109
25 GO:0060391 positive regulation of SMAD protein signal transduction 7.979E-6 1.669E-4 1.141E-3 4.173E-3 2 12
26 GO:0001837 epithelial to mesenchymal transition 8.305E-6 1.671E-4 1.142E-3 4.344E-3 3 117
27 GO:0046824 positive regulation of nucleocytoplasmic transport 1.088E-5 2.103E-4 1.438E-3 5.690E-3 3 128
28 GO:0050680 negative regulation of epithelial cell proliferation 1.140E-5 2.103E-4 1.438E-3 5.961E-3 3 130
29 GO:2000736 regulation of stem cell differentiation 1.166E-5 2.103E-4 1.438E-3 6.100E-3 3 131
30 GO:1900182 positive regulation of protein localization to nucleus 1.364E-5 2.377E-4 1.625E-3 7.131E-3 3 138
31 GO:0060390 regulation of SMAD protein signal transduction 1.450E-5 2.446E-4 1.672E-3 7.582E-3 2 16
32 GO:0003272 endocardial cushion formation 1.848E-5 3.020E-4 2.065E-3 9.663E-3 2 18
33 GO:0060491 regulation of cell projection assembly 2.730E-5 4.326E-4 2.958E-3 1.428E-2 3 174
34 GO:0014031 mesenchymal cell development 3.332E-5 5.041E-4 3.447E-3 1.742E-2 3 186
35 GO:0042306 regulation of protein import into nucleus 3.440E-5 5.041E-4 3.447E-3 1.799E-2 3 188
36 GO:0003203 endocardial cushion morphogenesis 3.618E-5 5.041E-4 3.447E-3 1.892E-2 2 25
37 GO:0048864 stem cell development 3.663E-5 5.041E-4 3.447E-3 1.916E-2 3 192
38 GO:1904589 regulation of protein import 3.663E-5 5.041E-4 3.447E-3 1.916E-2 3 192
39 GO:0048762 mesenchymal cell differentiation 4.137E-5 5.533E-4 3.783E-3 2.164E-2 3 200
40 GO:0060317 cardiac epithelial to mesenchymal transition 4.232E-5 5.533E-4 3.783E-3 2.213E-2 2 27
41 GO:0032967 positive regulation of collagen biosynthetic process 4.893E-5 6.242E-4 4.268E-3 2.559E-2 2 29
42 GO:0051491 positive regulation of filopodium assembly 5.242E-5 6.376E-4 4.359E-3 2.741E-2 2 30
43 GO:0010714 positive regulation of collagen metabolic process 5.242E-5 6.376E-4 4.359E-3 2.741E-2 2 30
44 GO:0001937 negative regulation of endothelial cell proliferation 6.359E-5 7.537E-4 5.154E-3 3.326E-2 2 33
45 GO:0043627 response to estrogen 6.604E-5 7.537E-4 5.154E-3 3.454E-2 3 234
46 GO:1900180 regulation of protein localization to nucleus 6.689E-5 7.537E-4 5.154E-3 3.498E-2 3 235
47 GO:0046822 regulation of nucleocytoplasmic transport 6.774E-5 7.537E-4 5.154E-3 3.543E-2 3 236
48 GO:0003007 heart morphogenesis 8.232E-5 8.970E-4 6.133E-3 4.305E-2 3 252
49 GO:0003197 endocardial cushion development 8.459E-5 9.029E-4 6.174E-3 4.424E-2 2 38
50 GO:0032965 regulation of collagen biosynthetic process 9.382E-5 9.814E-4 6.711E-3 4.907E-2 2 40
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 83 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070022 transforming growth factor beta receptor complex 6.934E-7 5.755E-5 2.879E-4 5.755E-5 2 4
2 GO:1902554 serine/threonine protein kinase complex 3.694E-4 8.708E-3 4.356E-2 3.066E-2 2 81
3 GO:1902911 protein kinase complex 4.764E-4 8.708E-3 4.356E-2 3.954E-2 2 92
4 GO:0060205 cytoplasmic vesicle lumen 6.082E-4 8.708E-3 4.356E-2
5.048E-2
 2 104
5 GO:0031983 vesicle lumen 6.557E-4 8.708E-3 4.356E-2
5.442E-2
 2 108
6 GO:0097226 sperm mitochondrial sheath 7.344E-4 8.708E-3 4.356E-2
6.095E-2
 1 2
7 GO:0072563 endothelial microparticle 7.344E-4 8.708E-3 4.356E-2
6.095E-2
 1 2
8 GO:0097524 sperm plasma membrane 1.468E-3 1.523E-2
7.620E-2
1.219E-1
 1 4
9 GO:0098802 plasma membrane receptor complex 1.805E-3 1.665E-2
8.328E-2
1.498E-1
 2 180
10 GO:0016323 basolateral plasma membrane 3.285E-3 2.467E-2
1.234E-1
2.726E-1
 2 244
11 GO:0061695 transferase complex, transferring phosphorus-containing groups 3.285E-3 2.467E-2
1.234E-1
2.726E-1
 2 244
12 GO:0030139 endocytic vesicle 3.862E-3 2.467E-2
1.234E-1
3.205E-1
 2 265
13 GO:0036020 endolysosome membrane 4.399E-3 2.467E-2
1.234E-1
3.651E-1
 1 12
14 GO:0032797 SMN complex 4.765E-3 2.467E-2
1.234E-1
3.955E-1
 1 13
15 GO:0030122 AP-2 adaptor complex 4.765E-3 2.467E-2
1.234E-1
3.955E-1
 1 13
16 GO:0030128 clathrin coat of endocytic vesicle 5.131E-3 2.467E-2
1.234E-1
4.259E-1
 1 14
17 GO:0016324 apical plasma membrane 6.101E-3 2.467E-2
1.234E-1
5.064E-1
 2 335
18 GO:0034719 SMN-Sm protein complex 6.227E-3 2.467E-2
1.234E-1
5.169E-1
 1 17
19 GO:0036019 endolysosome 6.227E-3 2.467E-2
1.234E-1
5.169E-1
 1 17
20 GO:0071682 endocytic vesicle lumen 6.227E-3 2.467E-2
1.234E-1
5.169E-1
 1 17
21 GO:0043235 receptor complex 6.243E-3 2.467E-2
1.234E-1
5.182E-1
 2 339
22 GO:0030132 clathrin coat of coated pit 6.958E-3 2.625E-2
1.313E-1
5.775E-1
 1 19
23 GO:0030125 clathrin vesicle coat 9.146E-3 3.301E-2
1.651E-1
7.592E-1
 1 25
24 GO:0045177 apical part of cell 9.803E-3 3.390E-2
1.696E-1
8.136E-1
 2 428
25 GO:0031012 extracellular matrix 1.052E-2 3.493E-2
1.747E-1
8.732E-1
 2 444
26 GO:0030131 clathrin adaptor complex 1.097E-2 3.501E-2
1.751E-1
9.103E-1
 1 30
Show 21 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 361 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0030872 Abnormal cardiac ventricular function 1.199E-6 2.083E-4 1.347E-3 4.328E-4 3 51
2 HP:0004944 Dilatation of the cerebral artery 1.684E-6 2.083E-4 1.347E-3 6.081E-4 3 57
3 HP:0000965 Cutis marmorata 2.634E-6 2.083E-4 1.347E-3 9.510E-4 3 66
4 HP:0002138 Subarachnoid hemorrhage 2.758E-6 2.083E-4 1.347E-3 9.956E-4 3 67
5 HP:0012703 Abnormality of the subarachnoid space 2.885E-6 2.083E-4 1.347E-3 1.042E-3 3 68
6 HP:0002326 Transient ischemic attack 5.892E-6 3.545E-4 2.293E-3 2.127E-3 3 86
7 HP:0001342 Cerebral hemorrhage 1.312E-5 5.439E-4 3.518E-3 4.737E-3 3 112
8 HP:0002140 Ischemic stroke 1.874E-5 5.439E-4 3.518E-3 6.765E-3 3 126
9 HP:0012180 Cystic medial necrosis 2.109E-5 5.439E-4 3.518E-3 7.615E-3 2 13
10 HP:0012763 Paroxysmal dyspnea 2.109E-5 5.439E-4 3.518E-3 7.615E-3 2 13
11 HP:0004954 Dilatation of the descending aortic 2.109E-5 5.439E-4 3.518E-3 7.615E-3 2 13
12 HP:0012499 Descending aortic dissection 2.109E-5 5.439E-4 3.518E-3 7.615E-3 2 13
13 HP:0004959 Descending thoracic aorta aneurysm 2.109E-5 5.439E-4 3.518E-3 7.615E-3 2 13
14 HP:0200146 Mucoid extracellular matrix accumulation 2.109E-5 5.439E-4 3.518E-3 7.615E-3 2 13
15 HP:0002617 Dilatation 2.361E-5 5.552E-4 3.591E-3 8.522E-3 3 136
16 HP:0012163 Carotid artery dilatation 2.461E-5 5.552E-4 3.591E-3 8.883E-3 2 14
17 HP:0002105 Hemoptysis 4.079E-5 8.662E-4 5.602E-3 1.473E-2 3 163
18 HP:0100775 Dural ectasia 4.621E-5 8.779E-4 5.678E-3 1.668E-2 2 19
19 HP:0004933 Ascending aortic dissection 4.621E-5 8.779E-4 5.678E-3 1.668E-2 2 19
20 HP:0002170 Intracranial hemorrhage 5.411E-5 9.487E-4 6.136E-3 1.953E-2 3 179
21 HP:0010303 Abnormal spinal meningeal morphology 5.673E-5 9.487E-4 6.136E-3 2.048E-2 2 21
22 HP:0002637 Cerebral ischemia 5.977E-5 9.487E-4 6.136E-3 2.158E-2 3 185
23 HP:0005162 Left ventricular dysfunction 6.239E-5 9.487E-4 6.136E-3 2.252E-2 2 22
24 HP:0005116 Arterial tortuosity 6.833E-5 9.487E-4 6.136E-3 2.467E-2 2 23
25 HP:0012727 Thoracic aortic aneurysm 6.833E-5 9.487E-4 6.136E-3 2.467E-2 2 23
26 HP:0002631 Dilatation of ascending aorta 6.833E-5 9.487E-4 6.136E-3 2.467E-2 2 23
27 HP:0004948 Vascular tortuosity 8.773E-5 1.173E-3 7.586E-3 3.167E-2 2 26
28 HP:0009145 Abnormal cerebral artery morphology 9.403E-5 1.212E-3 7.841E-3 3.395E-2 3 215
29 HP:0004950 Peripheral arterial stenosis 1.096E-4 1.364E-3 8.820E-3 3.955E-2 2 29
30 HP:0004953 Dilatation of abdominal aorta 1.513E-4 1.820E-3 1.177E-2
5.461E-2
 2 34
31 HP:0100545 Arterial stenosis 1.686E-4 1.902E-3 1.230E-2
6.088E-2
 3 261
32 HP:0005114 Abnormalities of the peripheral arteries 1.686E-4 1.902E-3 1.230E-2
6.088E-2
 3 261
33 HP:0011106 Hypovolemia 2.319E-4 2.508E-3 1.622E-2
8.371E-2
 2 42
34 HP:0005112 Abdominal aortic aneurysm 2.432E-4 2.508E-3 1.622E-2
8.778E-2
 2 43
35 HP:0011104 Abnormality of blood volume homeostasis 2.432E-4 2.508E-3 1.622E-2
8.778E-2
 2 43
36 HP:0001933 Subcutaneous hemorrhage 2.539E-4 2.546E-3 1.647E-2
9.166E-2
 3 299
37 HP:0005120 Abnormal cardiac atrium morphology 2.643E-4 2.578E-3 1.668E-2
9.540E-2
 3 303
38 HP:0000577 Exotropia 3.706E-4 3.520E-3 2.277E-2
1.338E-1
 2 53
39 HP:0002647 Aortic dissection 4.442E-4 4.112E-3 2.659E-2
1.604E-1
 2 58
40 HP:0001297 Stroke 4.627E-4 4.176E-3 2.701E-2
1.671E-1
 3 365
41 HP:0005344 Abnormal carotid artery morphology 4.755E-4 4.187E-3 2.708E-2
1.717E-1
 2 60
42 HP:0005111 Dilatation of the ascending aorta 5.079E-4 4.365E-3 2.823E-2
1.833E-1
 2 62
43 HP:0011029 Internal hemorrhage 5.348E-4 4.490E-3 2.904E-2
1.931E-1
 3 383
44 HP:0006830 Severe neonatal hypotonia in males 6.373E-4 5.229E-3 3.382E-2
2.301E-1
 1 1
45 HP:0000592 Blue sclerae 7.241E-4 5.809E-3 3.757E-2
2.614E-1
 2 74
46 HP:0004942 Aortic aneurysm 7.841E-4 6.154E-3 3.980E-2
2.831E-1
 2 77
47 HP:0001647 Bicuspid aortic valve 8.678E-4 6.393E-3 4.135E-2
3.133E-1
 2 81
48 HP:0031567 Abnormal aortic valve cusp morphology 8.678E-4 6.393E-3 4.135E-2
3.133E-1
 2 81
49 HP:0001659 Aortic regurgitation 8.678E-4 6.393E-3 4.135E-2
3.133E-1
 2 81
50 HP:0001634 Mitral valve prolapse 9.782E-4 6.916E-3 4.473E-2
3.531E-1
 2 86
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 281 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0001719 absent vitelline blood vessels 7.782E-6 2.157E-3 1.341E-2 2.187E-3 3 77
2 MP:0005243 hemothorax 1.535E-5 2.157E-3 1.341E-2 4.314E-3 2 11
3 MP:0010856 dilated respiratory conducting tubes 6.430E-5 6.023E-3 3.745E-2 1.807E-2 2 22
4 MP:0003229 abnormal vitelline vasculature morphology 2.335E-4 1.641E-2
1.020E-1
6.562E-2
 3 240
5 MP:0004178 neck telangiectases 5.794E-4 2.035E-2
1.265E-1
1.628E-1
 1 1
6 MP:0004177 tail telangiectases 5.794E-4 2.035E-2
1.265E-1
1.628E-1
 1 1
7 MP:0003609 small scrotum 5.794E-4 2.035E-2
1.265E-1
1.628E-1
 1 1
8 MP:0004176 ear telangiectases 5.794E-4 2.035E-2
1.265E-1
1.628E-1
 1 1
9 MP:0001634 internal hemorrhage 6.920E-4 2.161E-2
1.343E-1
1.944E-1
 3 347
10 MP:0002295 abnormal pulmonary circulation 8.883E-4 2.459E-2
1.529E-1
2.496E-1
 2 81
11 MP:0010531 gastrointestinal arteriovenous malformation 1.159E-3 2.459E-2
1.529E-1
3.256E-1
 1 2
12 MP:0000260 abnormal angiogenesis 1.251E-3 2.459E-2
1.529E-1
3.517E-1
 3 425
13 MP:0004391 abnormal respiratory conducting tube morphology 1.350E-3 2.459E-2
1.529E-1
3.795E-1
 2 100
14 MP:0001429 dehydration 1.350E-3 2.459E-2
1.529E-1
3.795E-1
 2 100
15 MP:0004950 abnormal brain vasculature morphology 1.350E-3 2.459E-2
1.529E-1
3.795E-1
 2 100
16 MP:0014012 abnormal cranial blood vasculature morphology 1.432E-3 2.459E-2
1.529E-1
4.024E-1
 2 103
17 MP:0005592 abnormal vascular smooth muscle morphology 1.488E-3 2.459E-2
1.529E-1
4.180E-1
 2 105
18 MP:0003641 small lung 1.970E-3 3.012E-2
1.873E-1
5.536E-1
 2 121
19 MP:0009889 persistence of medial edge epithelium during palatal shelf fusion 2.316E-3 3.012E-2
1.873E-1
6.508E-1
 1 4
20 MP:0013139 moribund 2.316E-3 3.012E-2
1.873E-1
6.508E-1
 1 4
21 MP:0005312 pericardial effusion 2.590E-3 3.012E-2
1.873E-1
7.279E-1
 2 139
22 MP:0011575 dilated aorta bulb 2.894E-3 3.012E-2
1.873E-1
8.133E-1
 1 5
23 MP:0012732 abnormal perineural vascular plexus morphology 2.894E-3 3.012E-2
1.873E-1
8.133E-1
 1 5
24 MP:0003752 increased oral papilloma incidence 2.894E-3 3.012E-2
1.873E-1
8.133E-1
 1 5
25 MP:0010530 cerebral arteriovenous malformation 2.894E-3 3.012E-2
1.873E-1
8.133E-1
 1 5
26 MP:0000265 atretic vasculature 2.894E-3 3.012E-2
1.873E-1
8.133E-1
 1 5
27 MP:0030356 premature lambdoid suture closure 2.894E-3 3.012E-2
1.873E-1
8.133E-1
 1 5
28 MP:0012501 abnormal pericardial cavity morphology 3.089E-3 3.100E-2
1.927E-1
8.680E-1
 2 152
29 MP:0000767 abnormal smooth muscle morphology 3.210E-3 3.110E-2
1.934E-1
9.020E-1
 2 155
30 MP:0030350 premature coronal suture closure 3.472E-3 3.252E-2
2.022E-1
9.757E-1
 1 6
31 MP:0001176 abnormal lung development 3.673E-3 3.329E-2
2.070E-1
1.000E0
 2 166
32 MP:0004175 telangiectases 4.050E-3 3.347E-2
2.081E-1
1.000E0
 1 7
33 MP:0005299 abnormal eye posterior chamber morphology 4.050E-3 3.347E-2
2.081E-1
1.000E0
 1 7
34 MP:0002669 abnormal scrotum morphology 4.050E-3 3.347E-2
2.081E-1
1.000E0
 1 7
35 MP:0004881 abnormal lung size 4.590E-3 3.514E-2
2.185E-1
1.000E0
 2 186
36 MP:0010949 decreased Clara cell number 4.628E-3 3.514E-2
2.185E-1
1.000E0
 1 8
37 MP:0011902 increased hematopoietic stem cell proliferation 4.628E-3 3.514E-2
2.185E-1
1.000E0
 1 8
38 MP:0003115 abnormal respiratory system development 4.835E-3 3.575E-2
2.223E-1
1.000E0
 2 191
39 MP:0005023 abnormal wound healing 5.446E-3 3.924E-2
2.440E-1
1.000E0
 2 203
40 MP:0030006 decreased retinal apoptosis 5.782E-3 3.963E-2
2.464E-1
1.000E0
 1 10
41 MP:0010661 ascending aorta aneurysm 5.782E-3 3.963E-2
2.464E-1
1.000E0
 1 10
42 MP:0002052 decreased tumor incidence 6.147E-3 4.113E-2
2.557E-1
1.000E0
 2 216
43 MP:0002270 abnormal pulmonary alveolus morphology 6.484E-3 4.188E-2
2.604E-1
1.000E0
 2 222
44 MP:0000164 abnormal cartilage development 6.656E-3 4.188E-2
2.604E-1
1.000E0
 2 225
45 MP:0010658 thoracic aorta aneurysm 6.935E-3 4.188E-2
2.604E-1
1.000E0
 1 12
46 MP:0009874 abnormal interdigital cell death 6.935E-3 4.188E-2
2.604E-1
1.000E0
 1 12
47 MP:0001718 abnormal visceral yolk sac morphology 7.005E-3 4.188E-2
2.604E-1
1.000E0
 2 231
48 MP:0002726 abnormal pulmonary vein morphology 7.511E-3 4.221E-2
2.624E-1
1.000E0
 1 13
49 MP:0004044 aortic dissection 7.511E-3 4.221E-2
2.624E-1
1.000E0
 1 13
50 MP:0010996 increased aorta wall thickness 7.511E-3 4.221E-2
2.624E-1
1.000E0
 1 13
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 81 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR015618 TGFB3 InterPro 3.736E-4 9.308E-3 4.633E-2 3.026E-2 1 1
2 2.60.40.1150 - Gene3D 7.471E-4 9.308E-3 4.633E-2
6.052E-2
 1 2
3 IPR013037 Clathrin b-adaptin app Ig-like InterPro 7.471E-4 9.308E-3 4.633E-2
6.052E-2
 1 2
4 IPR016342 AP complex bsu 1 2 4 InterPro 1.121E-3 9.308E-3 4.633E-2
9.076E-2
 1 3
5 PF09066 B2-adapt-app C Pfam 1.121E-3 9.308E-3 4.633E-2
9.076E-2
 1 3
6 IPR019805 Heat shock protein 90 CS InterPro 1.121E-3 9.308E-3 4.633E-2
9.076E-2
 1 3
7 IPR016319 TGF-beta InterPro 1.121E-3 9.308E-3 4.633E-2
9.076E-2
 1 3
8 IPR020575 Hsp90 N InterPro 1.494E-3 9.308E-3 4.633E-2
1.210E-1
 1 4
9 SM01020 B2-adapt-app C SMART 1.494E-3 9.308E-3 4.633E-2
1.210E-1
 1 4
10 IPR015151 B-adaptin app sub C InterPro 1.494E-3 9.308E-3 4.633E-2
1.210E-1
 1 4
11 PF00183 HSP90 Pfam 1.494E-3 9.308E-3 4.633E-2
1.210E-1
 1 4
12 PS00298 HSP90 PROSITE 1.494E-3 9.308E-3 4.633E-2
1.210E-1
 1 4
13 IPR001404 Hsp90 fam InterPro 1.494E-3 9.308E-3 4.633E-2
1.210E-1
 1 4
14 IPR026739 AP beta InterPro 1.867E-3 1.058E-2
5.268E-2
1.512E-1
 1 5
15 3.30.310.10 - Gene3D 2.240E-3 1.058E-2
5.268E-2
1.814E-1
 1 6
16 IPR012295 Beta2 adaptin/TBP C dom InterPro 2.240E-3 1.058E-2
5.268E-2
1.814E-1
 1 6
17 PS51256 GS PROSITE 2.613E-3 1.058E-2
5.268E-2
2.116E-1
 1 7
18 IPR003605 GS dom InterPro 2.613E-3 1.058E-2
5.268E-2
2.116E-1
 1 7
19 PF08515 TGF beta GS Pfam 2.613E-3 1.058E-2
5.268E-2
2.116E-1
 1 7
20 SM00467 GS SMART 2.613E-3 1.058E-2
5.268E-2
2.116E-1
 1 7
21 IPR009028 Coatomer/calthrin app sub C InterPro 2.986E-3 1.133E-2
5.642E-2
2.418E-1
 1 8
22 IPR008152 Clathrin a/b/g-adaptin app Ig InterPro 3.358E-3 1.133E-2
5.642E-2
2.720E-1
 1 9
23 SM00809 Alpha adaptinC2 SMART 3.358E-3 1.133E-2
5.642E-2
2.720E-1
 1 9
24 PF02883 Alpha adaptinC2 Pfam 3.358E-3 1.133E-2
5.642E-2
2.720E-1
 1 9
25 IPR000472 Activin recp InterPro 3.731E-3 1.162E-2
5.786E-2
3.022E-1
 1 10
26 PF01064 Activin recp Pfam 3.731E-3 1.162E-2
5.786E-2
3.022E-1
 1 10
27 IPR013041 Coatomer/clathrin app Ig-like InterPro 4.476E-3 1.295E-2
6.445E-2
3.625E-1
 1 12
28 IPR000333 TGFB receptor InterPro 4.476E-3 1.295E-2
6.445E-2
3.625E-1
 1 12
29 PF01602 Adaptin N Pfam 5.592E-3 1.466E-2
7.299E-2
4.529E-1
 1 15
30 IPR002553 Clathrin/coatomer adapt-like N InterPro 5.592E-3 1.466E-2
7.299E-2
4.529E-1
 1 15
31 IPR001507 ZP dom InterPro 6.335E-3 1.466E-2
7.299E-2
5.132E-1
 1 17
32 PF00100 Zona pellucida Pfam 6.335E-3 1.466E-2
7.299E-2
5.132E-1
 1 17
33 PF02984 Cyclin C Pfam 6.335E-3 1.466E-2
7.299E-2
5.132E-1
 1 17
34 IPR004367 Cyclin C-dom InterPro 6.335E-3 1.466E-2
7.299E-2
5.132E-1
 1 17
35 SM01332 Cyclin C SMART 6.335E-3 1.466E-2
7.299E-2
5.132E-1
 1 17
36 SM00387 HATPase c SMART 6.707E-3 1.509E-2
7.512E-2
5.433E-1
 1 18
37 PF02518 HATPase c Pfam 7.079E-3 1.550E-2
7.714E-2
5.734E-1
 1 19
38 3.30.565.10 - Gene3D 7.821E-3 1.667E-2
8.299E-2
6.335E-1
 1 21
39 IPR003594 HATPase C InterPro 8.192E-3 1.701E-2
8.470E-2
6.636E-1
 1 22
40 PS00292 CYCLINS PROSITE 1.042E-2 2.009E-2
1.000E-1
8.437E-1
 1 28
41 IPR001111 TGF-b N InterPro 1.042E-2 2.009E-2
1.000E-1
8.437E-1
 1 28
42 PF00688 TGFb propeptide Pfam 1.042E-2 2.009E-2
1.000E-1
8.437E-1
 1 28
43 IPR015615 TGF-beta-rel InterPro 1.190E-2 2.141E-2
1.066E-1
9.637E-1
 1 32
44 IPR017948 TGFb CS InterPro 1.190E-2 2.141E-2
1.066E-1
9.637E-1
 1 32
45 PF00134 Cyclin N Pfam 1.227E-2 2.141E-2
1.066E-1
9.936E-1
 1 33
46 IPR006671 Cyclin N InterPro 1.227E-2 2.141E-2
1.066E-1
9.936E-1
 1 33
47 IPR020568 Ribosomal S5 D2-typ fold InterPro 1.301E-2 2.141E-2
1.066E-1
1.000E0
 1 35
48 PS00250 TGF BETA 1 PROSITE 1.374E-2 2.141E-2
1.066E-1
1.000E0
 1 37
49 IPR001839 TGF-b C InterPro 1.374E-2 2.141E-2
1.066E-1
1.000E0
 1 37
50 PF00019 TGF beta Pfam 1.374E-2 2.141E-2
1.066E-1
1.000E0
 1 37
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 208 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138024 TGF-beta receptor signaling BioSystems: Pathway Interaction Database 2.241E-6 4.661E-4 2.758E-3 4.661E-4 3 51
2 921162 FoxO signaling pathway BioSystems: KEGG 3.953E-5 2.184E-3 1.292E-2 8.222E-3 3 132
3 M18933 TGF beta signaling pathway MSigDB C2 BIOCARTA (v6.0) 4.613E-5 2.184E-3 1.292E-2 9.595E-3 2 19
4 M18215 Role of Tob in T-cell activation MSigDB C2 BIOCARTA (v6.0) 5.662E-5 2.184E-3 1.292E-2 1.178E-2 2 21
5 M11420 CTCF: First Multivalent Nuclear Factor MSigDB C2 BIOCARTA (v6.0) 6.817E-5 2.184E-3 1.292E-2 1.418E-2 2 23
6 137968 ALK1 signaling events BioSystems: Pathway Interaction Database 7.435E-5 2.184E-3 1.292E-2 1.547E-2 2 24
7 138010 Glypican 1 network BioSystems: Pathway Interaction Database 8.751E-5 2.184E-3 1.292E-2 1.820E-2 2 26
8 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 8.751E-5 2.184E-3 1.292E-2 1.820E-2 2 26
9 1269525 Downregulation of TGF-beta receptor signaling BioSystems: REACTOME 9.448E-5 2.184E-3 1.292E-2 1.965E-2 2 27
10 1269524 TGF-beta receptor signaling activates SMADs BioSystems: REACTOME 1.507E-4 3.135E-3 1.855E-2 3.135E-2 2 34
11 M17400 ALK in cardiac myocytes MSigDB C2 BIOCARTA (v6.0) 1.788E-4 3.381E-3 2.000E-2 3.719E-2 2 37
12 M862 p38 MAPK Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 2.092E-4 3.627E-3 2.146E-2 4.352E-2 2 40
13 373901 HTLV-I infection BioSystems: KEGG 2.829E-4 4.400E-3 2.603E-2
5.884E-2
 3 256
14 102279 Endocytosis BioSystems: KEGG 2.961E-4 4.400E-3 2.603E-2
6.160E-2
 3 260
15 83106 Colorectal cancer BioSystems: KEGG 4.722E-4 6.548E-3 3.875E-2
9.823E-2
 2 60
16 1383017 The role of GTSE1 in G2/M progression after G2 checkpoint BioSystems: REACTOME 5.207E-4 6.574E-3 3.890E-2
1.083E-1
 2 63
17 83108 Pancreatic cancer BioSystems: KEGG 5.373E-4 6.574E-3 3.890E-2
1.118E-1
 2 64
18 83116 Chronic myeloid leukemia BioSystems: KEGG 6.611E-4 7.639E-3 4.520E-2
1.375E-1
 2 71
19 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 7.771E-4 8.507E-3
5.034E-2
1.616E-1
 2 77
20 83064 TGF-beta signaling pathway BioSystems: KEGG 9.241E-4 9.282E-3
5.493E-2
1.922E-1
 2 84
21 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.909E-4 9.282E-3
5.493E-2
2.061E-1
 2 87
22 83105 Pathways in cancer BioSystems: KEGG 1.009E-3 9.282E-3
5.493E-2
2.098E-1
 3 395
23 1269803 Regulation of PLK1 Activity at G2/M Transition BioSystems: REACTOME 1.060E-3 9.282E-3
5.493E-2
2.205E-1
 2 90
24 P00052 TGF-beta signaling pathway PantherDB 1.084E-3 9.282E-3
5.493E-2
2.254E-1
 2 91
25 1269116 vRNP Assembly BioSystems: REACTOME 1.124E-3 9.282E-3
5.493E-2
2.338E-1
 1 2
26 1270330 EPH-Ephrin signaling BioSystems: REACTOME 1.180E-3 9.282E-3
5.493E-2
2.455E-1
 2 95
27 119304 Progesterone-mediated oocyte maturation BioSystems: KEGG 1.205E-3 9.282E-3
5.493E-2
2.506E-1
 2 96
28 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 1.281E-3 9.514E-3
5.630E-2
2.664E-1
 2 99
29 147809 Chagas disease (American trypanosomiasis) BioSystems: KEGG 1.359E-3 9.747E-3
5.767E-2
2.827E-1
 2 102
30 1469482 Th17 cell differentiation BioSystems: KEGG 1.494E-3 1.036E-2
6.130E-2
3.108E-1
 2 107
31 83054 Cell cycle BioSystems: KEGG 2.000E-3 1.342E-2
7.940E-2
4.160E-1
 2 124
32 694606 Hepatitis B BioSystems: KEGG 2.686E-3 1.579E-2
9.342E-2
5.586E-1
 2 144
33 1268902 TGFBR2 Kinase Domain Mutants in Cancer BioSystems: REACTOME 2.809E-3 1.579E-2
9.342E-2
5.842E-1
 1 5
34 1268904 TGFBR1 LBD Mutants in Cancer BioSystems: REACTOME 2.809E-3 1.579E-2
9.342E-2
5.842E-1
 1 5
35 1268900 Loss of Function of TGFBR2 in Cancer BioSystems: REACTOME 2.809E-3 1.579E-2
9.342E-2
5.842E-1
 1 5
36 1269756 G2/M DNA replication checkpoint BioSystems: REACTOME 2.809E-3 1.579E-2
9.342E-2
5.842E-1
 1 5
37 1269802 Cyclin B2 mediated events BioSystems: REACTOME 2.809E-3 1.579E-2
9.342E-2
5.842E-1
 1 5
38 749777 Hippo signaling pathway BioSystems: KEGG 3.065E-3 1.678E-2
9.927E-2
6.375E-1
 2 154
39 1268898 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 3.369E-3 1.709E-2
1.011E-1
7.008E-1
 1 6
40 1269901 Scavenging by Class F Receptors BioSystems: REACTOME 3.369E-3 1.709E-2
1.011E-1
7.008E-1
 1 6
41 1269155 Uptake and function of diphtheria toxin BioSystems: REACTOME 3.369E-3 1.709E-2
1.011E-1
7.008E-1
 1 6
42 1268899 SMAD2/3 MH2 Domain Mutants in Cancer BioSystems: REACTOME 3.930E-3 1.777E-2
1.052E-1
8.175E-1
 1 7
43 1268897 Loss of Function of SMAD2/3 in Cancer BioSystems: REACTOME 3.930E-3 1.777E-2
1.052E-1
8.175E-1
 1 7
44 PW:0000614 altered transforming growth factor-beta Smad dependent signaling Pathway Ontology 3.930E-3 1.777E-2
1.052E-1
8.175E-1
 1 7
45 1269816 Activation of NIMA Kinases NEK9, NEK6, NEK7 BioSystems: REACTOME 3.930E-3 1.777E-2
1.052E-1
8.175E-1
 1 7
46 1269106 Nef Mediated CD8 Down-regulation BioSystems: REACTOME 3.930E-3 1.777E-2
1.052E-1
8.175E-1
 1 7
47 1269799 G2/M Transition BioSystems: REACTOME 4.345E-3 1.868E-2
1.105E-1
9.037E-1
 2 184
48 1269797 Mitotic G2-G2/M phases BioSystems: REACTOME 4.438E-3 1.868E-2
1.105E-1
9.230E-1
 2 186
49 1268905 TGFBR1 KD Mutants in Cancer BioSystems: REACTOME 4.490E-3 1.868E-2
1.105E-1
9.340E-1
 1 8
50 1268903 Loss of Function of TGFBR1 in Cancer BioSystems: REACTOME 4.490E-3 1.868E-2
1.105E-1
9.340E-1
 1 8
Show 45 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 2867 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1326540 Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells. Pubmed 3.769E-11 1.081E-7 9.227E-7 1.081E-7 3 5
2 9872992 Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily. Pubmed 6.216E-10 5.940E-7 5.072E-6 1.782E-6 3 11
3 17168649 A role for TGF-beta signaling in neurodegeneration: evidence from genetically engineered models. Pubmed 6.216E-10 5.940E-7 5.072E-6 1.782E-6 3 11
4 22560297 Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Pubmed 1.222E-8 8.755E-6 7.476E-5 3.502E-5 4 167
5 29065449 Chronic Venous Insufficiency: Transforming Growth Factor-β Isoforms and Soluble Endoglin Concentration in Different States of Wound Healing. Pubmed 2.879E-8 1.179E-5 1.007E-4 8.255E-5 2 2
6 18257072 Tissue-specific expression of Cre recombinase from the Tgfb3 locus. Pubmed 2.879E-8 1.179E-5 1.007E-4 8.255E-5 2 2
7 18156205 Severe intrauterine growth restriction pregnancies have increased placental endoglin levels: hypoxic regulation via transforming growth factor-beta 3. Pubmed 2.879E-8 1.179E-5 1.007E-4 8.255E-5 2 2
8 10433915 Pathogenesis of cleft palate in TGF-beta3 knockout mice. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
9 11850637 Crystal structure of the human TbetaR2 ectodomain--TGF-beta3 complex. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
10 21423151 TGF-β signalling is mediated by two autonomously functioning TβRI:TβRII pairs. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
11 21465483 Regulation of endothelial barrier function by TGF-β type I receptor ALK5: potential role of contractile mechanisms and heat shock protein 90. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
12 12429842 Transforming growth factor-beta receptors interact with AP2 by direct binding to beta2 subunit. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
13 18243111 Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
14 21170488 The role of the TGF-β coreceptor endoglin in cancer. Pubmed 8.637E-8 1.681E-5 1.436E-4 2.476E-4 2 3
15 15342483 TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Pubmed 8.796E-8 1.681E-5 1.436E-4 2.522E-4 3 53
16 22848678 HILI inhibits TGF-β signaling by interacting with Hsp90 and promoting TβR degradation. Pubmed 1.727E-7 2.358E-5 2.014E-4 4.952E-4 2 4
17 28633389 Multiple Soluble TGF-β Receptors in Addition to Soluble Endoglin Are Elevated in Preeclamptic Serum and They Synergistically Inhibit TGF-β Signaling. Pubmed 1.727E-7 2.358E-5 2.014E-4 4.952E-4 2 4
18 23548068 Variation in endoglin pathway genes is associated with preeclampsia: a case-control candidate gene association study. Pubmed 1.727E-7 2.358E-5 2.014E-4 4.952E-4 2 4
19 18974388 S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology. Pubmed 1.727E-7 2.358E-5 2.014E-4 4.952E-4 2 4
20 23103542 Differential response of epithelial stem cell populations in hair follicles to TGF-β signaling. Pubmed 1.727E-7 2.358E-5 2.014E-4 4.952E-4 2 4
21 28662367 Inhibition of the miR-17-92 Cluster Separates Stages of Palatogenesis. Pubmed 1.727E-7 2.358E-5 2.014E-4 4.952E-4 2 4
22 18591668 Critical regulation of TGFbeta signaling by Hsp90. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
23 12607775 Transforming growth factors beta1, beta2 and beta3 and their receptors are differentially expressed in human peritoneal fibroblasts in response to hypoxia. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
24 1333888 TGF beta signals through a heteromeric protein kinase receptor complex. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
25 12838410 Reduced programmed cell death in the retina and defects in lens and cornea of Tgfbeta2(-/-) Tgfbeta3(-/-) double-deficient mice. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
26 20856203 Critical role of endoglin in tumor cell plasticity of Ewing sarcoma and melanoma. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
27 12060054 Transforming growth factor-beta 1, 2, 3 and receptor type I and II in diabetic foot ulcers. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
28 15702480 Interaction and functional interplay between endoglin and ALK-1, two components of the endothelial transforming growth factor-beta receptor complex. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
29 12015308 Extracellular and cytoplasmic domains of endoglin interact with the transforming growth factor-beta receptors I and II. Pubmed 2.879E-7 2.846E-5 2.430E-4 8.253E-4 2 5
30 19299629 Sequencing of TGF-beta pathway genes in familial cases of intracranial aneurysm. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
31 11157754 Type III TGF-beta receptor-independent signalling of TGF-beta2 via TbetaRII-B, an alternatively spliced TGF-beta type II receptor. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
32 15020715 HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
33 9856985 Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
34 20042635 ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
35 19736306 Endoglin phosphorylation by ALK2 contributes to the regulation of prostate cancer cell migration. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
36 20301312 Loeys-Dietz Syndrome Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
37 26680585 ShcA Protects against Epithelial-Mesenchymal Transition through Compartmentalized Inhibition of TGF-β-Induced Smad Activation. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
38 7852346 The soluble exoplasmic domain of the type II transforming growth factor (TGF)-beta receptor. A heterogeneously glycosylated protein with high affinity and selectivity for TGF-beta ligands. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
39 24474796 Thymocyte apoptosis drives the intrathymic generation of regulatory T cells. Pubmed 4.318E-7 3.174E-5 2.710E-4 1.238E-3 2 6
40 17634193 Inhibition of Tgf beta signaling by endogenous retinoic acid is essential for primary lung bud induction. Pubmed 6.044E-7 3.851E-5 3.288E-4 1.733E-3 2 7
41 10757800 STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Pubmed 6.044E-7 3.851E-5 3.288E-4 1.733E-3 2 7
42 15761148 Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity. Pubmed 6.044E-7 3.851E-5 3.288E-4 1.733E-3 2 7
43 24760528 Vitamin D deficiency causes airway hyperresponsiveness, increases airway smooth muscle mass, and reduces TGF-β expression in the lungs of female BALB/c mice. Pubmed 6.044E-7 3.851E-5 3.288E-4 1.733E-3 2 7
44 19757385 TGFbeta3 is expressed in differentiating muscle of the embryonic mouse tongue. Pubmed 6.044E-7 3.851E-5 3.288E-4 1.733E-3 2 7
45 18945958 TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Pubmed 6.044E-7 3.851E-5 3.288E-4 1.733E-3 2 7
46 20603020 TGF-beta signaling specifies axons during brain development. Pubmed 8.058E-7 4.915E-5 4.197E-4 2.310E-3 2 8
47 23868260 LRG1 promotes angiogenesis by modulating endothelial TGF-β signalling. Pubmed 8.058E-7 4.915E-5 4.197E-4 2.310E-3 2 8
48 14729481 Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Pubmed 1.036E-6 6.188E-5 5.283E-4 2.970E-3 2 9
49 20346356 TGFbeta signaling in male germ cells regulates gonocyte quiescence and fertility in mice. Pubmed 1.295E-6 7.139E-5 6.095E-4 3.712E-3 2 10
50 17314099 NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling. Pubmed 1.295E-6 7.139E-5 6.095E-4 3.712E-3 2 10
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 1158 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TGFBR2 TGFBR2 interactions 1.967E-16 2.278E-13 1.739E-12 2.278E-13 7 104
2 int:TGFBR1 TGFBR1 interactions 1.298E-11 7.514E-9 5.735E-8 1.503E-8 6 199
3 int:ACVRL1 ACVRL1 interactions 1.079E-10 4.166E-8 3.179E-7 1.250E-7 4 25
4 int:TGFB3 TGFB3 interactions 1.719E-8 4.977E-6 3.798E-5 1.991E-5 3 15
5 int:ENG ENG interactions 3.081E-8 7.061E-6 5.389E-5 3.568E-5 3 18
6 int:TGFB2 TGFB2 interactions 3.658E-8 7.061E-6 5.389E-5 4.236E-5 3 19
7 int:KLHL1 KLHL1 interactions 2.009E-6 2.908E-4 2.219E-3 2.326E-3 2 6
8 int:AMHR2 AMHR2 interactions 2.009E-6 2.908E-4 2.219E-3 2.326E-3 2 6
9 int:ACVR1 ACVR1 interactions 4.683E-6 6.025E-4 4.599E-3 5.423E-3 3 92
10 int:ENC1 ENC1 interactions 1.604E-5 1.691E-3 1.291E-2 1.857E-2 2 16
11 int:EPHA2 EPHA2 interactions 1.801E-5 1.691E-3 1.291E-2 2.086E-2 3 144
12 int:PPP6C PPP6C interactions 1.995E-5 1.691E-3 1.291E-2 2.310E-2 3 149
13 int:FBXO34 FBXO34 interactions 2.044E-5 1.691E-3 1.291E-2 2.367E-2 2 18
14 int:TSSK1B TSSK1B interactions 2.044E-5 1.691E-3 1.291E-2 2.367E-2 2 18
15 int:STK35 STK35 interactions 2.804E-5 2.165E-3 1.652E-2 3.248E-2 2 21
16 int:NUAK2 NUAK2 interactions 3.377E-5 2.444E-3 1.866E-2 3.911E-2 2 23
17 int:PREB PREB interactions 4.682E-5 3.189E-3 2.434E-2
5.422E-2
 2 27
18 int:LARP4B LARP4B interactions 5.041E-5 3.243E-3 2.475E-2
5.838E-2
 2 28
19 int:CDK14 CDK14 interactions 5.799E-5 3.535E-3 2.698E-2
6.716E-2
 2 30
20 int:TGFBR3 TGFBR3 interactions 6.610E-5 3.827E-3 2.921E-2
7.654E-2
 2 32
21 int:NEK8 NEK8 interactions 7.474E-5 4.121E-3 3.145E-2
8.654E-2
 2 34
22 int:CKS2 CKS2 interactions 8.390E-5 4.416E-3 3.370E-2
9.715E-2
 2 36
23 int:FBXL12 FBXL12 interactions 1.201E-4 6.046E-3 4.615E-2
1.391E-1
 2 43
24 int:ITK ITK interactions 1.376E-4 6.638E-3
5.066E-2
1.593E-1
 2 46
25 int:SMAD6 SMAD6 interactions 1.829E-4 8.459E-3
6.456E-2
2.118E-1
 2 53
26 int:CKS1B CKS1B interactions 1.899E-4 8.459E-3
6.456E-2
2.199E-1
 2 54
27 int:ACVR2B ACVR2B interactions 2.043E-4 8.762E-3
6.688E-2
2.366E-1
 2 56
28 int:SCRIB SCRIB interactions 3.195E-4 1.322E-2
1.009E-1
3.700E-1
 2 70
29 int:BMPR2 BMPR2 interactions 3.381E-4 1.350E-2
1.030E-1
3.915E-1
 2 72
30 int:SMURF1 SMURF1 interactions 3.913E-4 1.482E-2
1.131E-1
4.531E-1
 3 406
31 int:PDPK1 PDPK1 interactions 3.967E-4 1.482E-2
1.131E-1
4.594E-1
 2 78
32 int:CDK7 CDK7 interactions 4.934E-4 1.786E-2
1.363E-1
5.714E-1
 2 87
33 int:DAB2 DAB2 interactions 5.163E-4 1.798E-2
1.372E-1
5.979E-1
 2 89
34 int:TTC1 TTC1 interactions 5.279E-4 1.798E-2
1.372E-1
6.113E-1
 2 90
35 int:VCAM1 VCAM1 interactions 5.501E-4 1.820E-2
1.389E-1
6.370E-1
 3 456
36 int:RPAP3 RPAP3 interactions 5.880E-4 1.891E-2
1.444E-1
6.809E-1
 2 95
37 int:TAB2 TAB2 interactions 6.643E-4 2.079E-2
1.587E-1
7.693E-1
 2 101
38 int:SMAD7 SMAD7 interactions 7.591E-4 2.081E-2
1.588E-1
8.790E-1
 2 108
39 int:STRAP STRAP interactions 7.591E-4 2.081E-2
1.588E-1
8.790E-1
 2 108
40 int:TRIM73 TRIM73 interactions 7.907E-4 2.081E-2
1.588E-1
9.156E-1
 1 2
41 int:RRH RRH interactions 7.907E-4 2.081E-2
1.588E-1
9.156E-1
 1 2
42 int:STYK1 STYK1 interactions 7.907E-4 2.081E-2
1.588E-1
9.156E-1
 1 2
43 int:ISX ISX interactions 7.907E-4 2.081E-2
1.588E-1
9.156E-1
 1 2
44 int:STK32B STK32B interactions 7.907E-4 2.081E-2
1.588E-1
9.156E-1
 1 2
45 int:CDC25C CDC25C interactions 8.305E-4 2.137E-2
1.631E-1
9.618E-1
 2 113
46 int:BMPR1A BMPR1A interactions 8.900E-4 2.230E-2
1.702E-1
1.000E0
 2 117
47 int:SOCS6 SOCS6 interactions 9.051E-4 2.230E-2
1.702E-1
1.000E0
 2 118
48 int:AP2B1 AP2B1 interactions 9.514E-4 2.289E-2
1.747E-1
1.000E0
 2 121
49 int:PAK1 PAK1 interactions 9.829E-4 2.289E-2
1.747E-1
1.000E0
 2 123
50 int:ATR ATR interactions 9.988E-4 2.289E-2
1.747E-1
1.000E0
 2 124
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q11.2-q12 17q11.2-q12 1.413E-3 7.769E-3 2.014E-2 9.891E-3 1 7
2 14q24 14q24 2.220E-3 7.769E-3 2.014E-2 1.554E-2 1 11
3 9q22 9q22 3.831E-3 8.939E-3 2.318E-2 2.682E-2 1 19
4 12p12.3 12p12.3 6.445E-3 9.023E-3 2.340E-2 4.512E-2 1 32
5 15q22.2 15q22.2 6.445E-3 9.023E-3 2.340E-2 4.512E-2 1 32
6 9q34.11 9q34.11 1.186E-2 1.383E-2 3.586E-2
8.299E-2
 1 59
7 14q32.33 14q32.33 4.728E-2 4.728E-2
1.226E-1
3.310E-1
 1 239
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 75 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 586 Heat shock 90kDa proteins genenames.org 1.648E-3 6.920E-3 1.695E-2 9.888E-3 1 5
2 345 Type 1 receptor serine/threonine kinases|CD molecules genenames.org 2.307E-3 6.920E-3 1.695E-2 1.384E-2 1 7
3 473 Cyclins genenames.org 9.527E-3 1.905E-2 4.668E-2
5.716E-2
 1 29

13: Coexpression [Display Chart] 7 input genes in category / 1235 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M4011 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 24 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.858E-7 2.295E-4 1.766E-3 2.295E-4 4 200
2 16585153-Table1 Mouse Skin Hagendoorn06 54genes GeneSigDB 3.724E-7 2.299E-4 1.770E-3 4.599E-4 3 52
3 15073102-Table1d Human Breast Glinsky04 14genes survival GeneSigDB 4.310E-6 1.277E-3 9.830E-3 5.323E-3 2 11
4 15073102-Table1c Human Breast Glinsky04 12genes survival GeneSigDB 4.310E-6 1.277E-3 9.830E-3 5.323E-3 2 11
5 M208 Genes up-regulated in DLD-1 cells (colon cancer) in response to hypoxia; might not be direct targets of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.171E-6 1.277E-3 9.830E-3 6.386E-3 2 12
6 M12112 Angiogenic markers up-regulated in lymph endothelial cells upon infection with KSHV (Kaposi's sarcoma herpes virus). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.221E-5 2.486E-3 1.913E-2 1.507E-2 3 165
7 M11701 Selected genes up-regulated during invasion of lymphatic vessels during metastasis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.487E-5 2.486E-3 1.913E-2 1.836E-2 2 20
8 11823860-SuppTable2 Human Breast van'tVeer02 231genes PoorPrognosisSignature GeneSigDB 1.610E-5 2.486E-3 1.913E-2 1.989E-2 3 181
9 M5431 Genes down-regulated in comparison of mast cells versus macrophages. MSigDB C7: Immunologic Signatures (v6.0) 2.139E-5 2.935E-3 2.259E-2 2.641E-2 3 199
10 20156340-GENIUS-ERposHER2neg signature Human Breast HaibeKains10 229genes GENIUS ERposHER2neg GeneSigDB 2.886E-5 3.240E-3 2.494E-2 3.564E-2 3 220
11 18698033-tableS1-AURKA Human Breast Desmedt08 229genes AURKA Module GeneSigDB 2.886E-5 3.240E-3 2.494E-2 3.564E-2 3 220
12 17295094-GeneList Human Breast VandenEynden07 269genes-hypoxia angiogenesis GeneSigDB 4.914E-5 5.057E-3 3.892E-2
6.068E-2
 3 263
13 M1249 Genes up-regulated in B cell lymphoma tumors expressing an activated form of MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.717E-5 6.213E-3 4.782E-2
8.295E-2
 2 42
14 18778486-TableS3 Human Breast Karlsson08 46genes GeneSigDB 7.043E-5 6.213E-3 4.782E-2
8.698E-2
 2 43
15 11823860-Figure2 Human Breast van'tVeer02 70genes Mammaprint GeneSigDB 1.073E-4 7.149E-3
5.503E-2
1.325E-1
 2 53
16 18794116-Table1 Mouse Lymphoma Clasper08 56genes GeneSigDB 1.114E-4 7.149E-3
5.503E-2
1.376E-1
 2 54
17 M5896 Genes up-regulated in response to TGFB1 [GeneID=7040]. MSigDB H: Hallmark Gene Sets (v6.0) 1.114E-4 7.149E-3
5.503E-2
1.376E-1
 2 54
18 M14693 The optimal set of 70 prognostic markers predicting poor breast cancer clinical outcome (defined as developing metastases with 5 years). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.156E-4 7.149E-3
5.503E-2
1.428E-1
 2 55
19 17069664-SuppTable2 Human Breast Nuyten06 70genes hypoxia GeneSigDB 1.156E-4 7.149E-3
5.503E-2
1.428E-1
 2 55
20 M500 Genes whose expression is significantly and positively correlated with poor breast cancer clinical outcome (defined as developing distant metastases in less than 5 years). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.199E-4 7.149E-3
5.503E-2
1.481E-1
 2 56
21 17210682-Table2b Human Colon Grade07 101genes GeneSigDB 1.287E-4 7.149E-3
5.503E-2
1.589E-1
 2 58
22 17899371-GeneTable4 Human Breast Lauss08 374genes GeneSigDB 1.290E-4 7.149E-3
5.503E-2
1.593E-1
 3 364
23 20165955-Table2 Human Liver Simon10 81genes GeneSigDB 1.331E-4 7.149E-3
5.503E-2
1.644E-1
 2 59
24 M3274 Top up-regulated marker genes for medulloblastoma classification: desmoplastic vs classic morphology. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.471E-4 7.569E-3
5.826E-2
1.817E-1
 2 62
25 16533762-Table1 Human Uterine Matsumura06 67genes GeneSigDB 1.668E-4 8.238E-3
6.340E-2
2.059E-1
 2 66
26 16513839-Table3 Human Prostate Nanni06 70genes GeneSigDB 1.770E-4 8.409E-3
6.472E-2
2.186E-1
 2 68
27 M170 Genes down-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.154E-4 9.767E-3
7.517E-2
2.661E-1
 2 75
28 16488994-SuppTable1b Mouse Lung Lu06 856genes Array MEO430Av2 GeneSigDB 2.304E-4 9.767E-3
7.517E-2
2.846E-1
 3 443
29 19699293-TableS3 Human Breast Bienkowska09 103genes GeneSigDB 2.391E-4 9.767E-3
7.517E-2
2.953E-1
 2 79
30 16488994-SuppTable1a Mouse Lung Lu06 856genes Array MG U74Av2 GeneSigDB 2.398E-4 9.767E-3
7.517E-2
2.961E-1
 3 449
31 M1395 Up-regulated genes in the B lymphocyte developmental signature, based on expression profiling of lymphomas from the Emu-myc transgenic mice: the Pre-BI stage. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.452E-4 9.767E-3
7.517E-2
3.028E-1
 2 80
32 17284527-Table2 Human Lypmhoma Leval07 96genes GeneSigDB 2.703E-4 1.043E-2
8.029E-2
3.338E-1
 2 84
33 18199535-SuppTable3 Human StemCell Amundson08 138genes GeneSigDB 6.069E-4 2.210E-2
1.701E-1
7.496E-1
 2 126
34 16611997-Table2 Mouse StemCell Affar06 131genes GeneSigDB 6.166E-4 2.210E-2
1.701E-1
7.614E-1
 2 127
35 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.262E-4 2.210E-2
1.701E-1
7.734E-1
 2 128
36 M2902 Genes up-regulated in epithelial prostate cancer cell lines over-expressing an oncogenic form of KRAS [Gene ID=3845] gene. MSigDB C6: Oncogenic Signatures (v6.0) 7.484E-4 2.534E-2
1.950E-1
9.242E-1
 2 140
37 18427120-DataS5 Human Breast Crawford08 187genes GeneSigDB 7.590E-4 2.534E-2
1.950E-1
9.374E-1
 2 141
38 M11513 Genes down-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.043E-4 2.677E-2
2.060E-1
1.000E0
 2 154
39 M13108 Genes down-regulated in Wilm's tumor samples compared to fetal kidney. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.012E-3 2.677E-2
2.060E-1
1.000E0
 2 163
40 M8949 Genes up-regulated in T conv cells from aged PPARG [GeneID=5468] knockout: visceral adipose tissue versus lymph node. MSigDB C7: Immunologic Signatures (v6.0) 1.024E-3 2.677E-2
2.060E-1
1.000E0
 2 164
41 M6817 Genes up-regulated in dendritic cells: untreated versus anti-FcgRIIB. MSigDB C7: Immunologic Signatures (v6.0) 1.100E-3 2.677E-2
2.060E-1
1.000E0
 2 170
42 20368555-TS-2 Human Breast Barry10 205genes GeneSigDB 1.178E-3 2.677E-2
2.060E-1
1.000E0
 2 176
43 M3456 Genes identified by ChIP within the high-affinity group of MYC [GeneID=4609] targets. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.259E-3 2.677E-2
2.060E-1
1.000E0
 2 182
44 M2812 Genes down-regulated in CD34+ hematopoietic progenitor cells after knockdown of RPS14 [Gene ID=6208] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.329E-3 2.677E-2
2.060E-1
1.000E0
 2 187
45 M7943 Genes up-regulated in macrophages (12h): IFNG, TNF [GeneID=3458;7124] and rosiglitazone [PubChem=77999] versus rosiglitazone [PubChem=77999] and IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 1.429E-3 2.677E-2
2.060E-1
1.000E0
 2 194
46 M5491 Genes up-regulated in comparison of macrophages versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.677E-2
2.060E-1
1.000E0
 2 199
47 M8274 Genes down-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.677E-2
2.060E-1
1.000E0
 2 199
48 M8444 Genes down-regulated in lung innate lymphoid cells versus spleen CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.677E-2
2.060E-1
1.000E0
 2 199
49 M3701 Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with LPS (TLR4 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.677E-2
2.060E-1
1.000E0
 2 199
50 12606954-table1c Human Prostate Bigler03 6genes GeneSigDB 1.512E-3 2.677E-2
2.060E-1
1.000E0
 1 5
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 1245 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-A Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-A Lungmap CCHMC 8.132E-5 2.476E-2
1.908E-1
1.012E-1
 3 294
2 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D Lungmap CCHMC 8.465E-5 2.476E-2
1.908E-1
1.054E-1
 3 298
3 GSM605778 500 gamma delta T cells, Tgd.vg1+vd6+.Th.TCRbko, TCRd+ Vg1.1+ Vd6.3+, Thymus, avg-3 Immgen.org, GSE15907 1.125E-4 2.476E-2
1.908E-1
1.401E-1
 3 328
4 GSM476675 500 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 1.352E-4 2.476E-2
1.908E-1
1.683E-1
 3 349
5 GSM605784 500 gamma delta T cells, Tgd.vg1+vd6-.Th.TCRbko, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 1.519E-4 2.476E-2
1.908E-1
1.891E-1
 3 363
6 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 1.646E-4 2.476E-2
1.908E-1
2.049E-1
 3 373
7 10X Human 8K PBMC unknown Subtype unknown-unknown Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-unknown Top 200 Genes 1.780E-4 2.476E-2
1.908E-1
2.216E-1
 3 383
8 GSM605799 500 gamma delta T cells, Tgd.vg2-24ahi.Th.TCRbko, TCRd+ Vg2- CD24+, Thymus, avg-3 Immgen.org, GSE15907 1.964E-4 2.476E-2
1.908E-1
2.446E-1
 3 396
9 GSM605793 500 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 2.208E-4 2.476E-2
1.908E-1
2.749E-1
 3 412
10 Lungmap Mouse Lung E16.5 Myofibroblast Subtype Migrating Myofibroblast Lungmap Mouse Lung E16.5 Myofibroblast Subtype Migrating Myofibroblast Lungmap CCHMC 2.288E-4 2.476E-2
1.908E-1
2.849E-1
 3 417
11 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 2.370E-4 2.476E-2
1.908E-1
2.950E-1
 3 422
12 GSM476655 500 gamma delta T cells, Tgd.vg2+24ahi.Th, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 2.386E-4 2.476E-2
1.908E-1
2.971E-1
 3 423
13 gudmap developingKidney e14.5 whole kidney - Wnt4 KO 200 k2 DevelopingKidney e14.5 whole kidney - Wnt4 KO emap-6674 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.892E-4 2.533E-2
1.951E-1
3.600E-1
 2 82
14 GSM476675 100 gamma delta T cells, Tgd.Th, TCRd+ CD3e+, Thymus, avg-3 Immgen.org, GSE15907 3.034E-4 2.533E-2
1.951E-1
3.778E-1
 2 84
15 GSM605793 100 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 3.107E-4 2.533E-2
1.951E-1
3.868E-1
 2 85
16 GSM476655 100 gamma delta T cells, Tgd.vg2+24ahi.Th, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 3.255E-4 2.533E-2
1.951E-1
4.052E-1
 2 87
17 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Synpr/Synpr,Pcdh11x BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Synpr/Synpr,Pcdh11x BrainMap 4.828E-4 3.468E-2
2.672E-1
6.011E-1
 2 106
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT9 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT9 Adult, Development, and Cancer types 5.198E-4 3.468E-2
2.672E-1
6.471E-1
 2 110
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Normal-Cortex Wilms T U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Normal-Cortex Wilms T U Adult, Development, and Cancer types 5.292E-4 3.468E-2
2.672E-1
6.589E-1
 2 111
Show 14 more annotations

15: Computational [Display Chart] 7 input genes in category / 86 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 358 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-6826-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.785E-5 1.003E-2
6.477E-2
 3.503E-2 2 157
2 hsa-miR-549:PITA hsa-miR-549:PITA TOP PITA 1.107E-4 1.003E-2
6.477E-2
 3.963E-2 2 167
3 hsa-miR-642:PITA hsa-miR-642:PITA TOP PITA 1.107E-4 1.003E-2
6.477E-2
 3.963E-2 2 167
4 hsa-miR-619:PITA hsa-miR-619:PITA TOP PITA 1.120E-4 1.003E-2
6.477E-2
 4.011E-2 2 168
5 hsa-miR-140-5p:PITA hsa-miR-140-5p:PITA TOP PITA 3.170E-4 2.246E-2
1.451E-1
1.135E-1
 2 283
6 hsa-miR-1271:PITA hsa-miR-1271:PITA TOP PITA 5.003E-4 2.246E-2
1.451E-1
1.791E-1
 2 356
7 hsa-miR-96:PITA hsa-miR-96:PITA TOP PITA 5.059E-4 2.246E-2
1.451E-1
1.811E-1
 2 358
8 hsa-miR-101-3p:Functional MTI Functional MTI miRTarbase 6.088E-4 2.246E-2
1.451E-1
2.180E-1
 2 393
9 hsa-let-7f-5p:Functional MTI Functional MTI miRTarbase 6.212E-4 2.246E-2
1.451E-1
2.224E-1
 2 397
10 hsa-miR-204-5p:Functional MTI Functional MTI miRTarbase 6.274E-4 2.246E-2
1.451E-1
2.246E-1
 2 399
11 hsa-miR-10a-5p:Functional MTI Functional MTI miRTarbase 8.426E-4 2.332E-2
1.507E-1
3.017E-1
 2 463
12 hsa-miR-1306:mirSVR lowEffct hsa-miR-1306:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.426E-4 2.332E-2
1.507E-1
3.017E-1
 2 463
13 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 9.162E-4 2.332E-2
1.507E-1
3.280E-1
 2 483
14 hsa-miR-425*:mirSVR lowEffct hsa-miR-425*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.695E-4 2.332E-2
1.507E-1
3.471E-1
 2 497
15 hsa-miR-490-3p:mirSVR highEffct hsa-miR-490-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 9.773E-4 2.332E-2
1.507E-1
3.499E-1
 2 499
16 hsa-miR-1306:PITA hsa-miR-1306:PITA TOP PITA 2.227E-3 3.835E-2
2.477E-1
7.971E-1
 1 23
17 hsa-miR-6798-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.710E-3 3.835E-2
2.477E-1
9.702E-1
 1 28
18 hsa-miR-656-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.807E-3 3.835E-2
2.477E-1
1.000E0
 1 29
19 hsa-miR-6755-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.193E-3 3.835E-2
2.477E-1
1.000E0
 1 33
20 hsa-miR-1298:PITA hsa-miR-1298:PITA TOP PITA 3.290E-3 3.835E-2
2.477E-1
1.000E0
 1 34
21 hsa-miR-1228-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.352E-3 3.835E-2
2.477E-1
1.000E0
 1 45
22 hsa-miR-342-5p:PITA hsa-miR-342-5p:PITA TOP PITA 4.449E-3 3.835E-2
2.477E-1
1.000E0
 1 46
23 hsa-miR-4703-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 3.835E-2
2.477E-1
1.000E0
 1 49
24 hsa-miR-550a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 3.835E-2
2.477E-1
1.000E0
 1 49
25 hsa-miR-200c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-3 3.835E-2
2.477E-1
1.000E0
 1 50
26 hsa-miR-4781-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-3 3.835E-2
2.477E-1
1.000E0
 1 50
27 hsa-miR-1278:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.932E-3 3.835E-2
2.477E-1
1.000E0
 1 51
28 hsa-miR-600:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.028E-3 3.835E-2
2.477E-1
1.000E0
 1 52
29 hsa-miR-8083:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 3.835E-2
2.477E-1
1.000E0
 1 53
30 hsa-miR-500b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.607E-3 3.835E-2
2.477E-1
1.000E0
 1 58
31 hsa-miR-1244:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.703E-3 3.835E-2
2.477E-1
1.000E0
 1 59
32 CCAGGTT,MIR-490:MSigDB CCAGGTT,MIR-490:MSigDB MSigDB 5.992E-3 3.835E-2
2.477E-1
1.000E0
 1 62
33 hsa-miR-219a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.089E-3 3.835E-2
2.477E-1
1.000E0
 1 63
34 hsa-miR-362-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.089E-3 3.835E-2
2.477E-1
1.000E0
 1 63
35 hsa-miR-3156-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.835E-2
2.477E-1
1.000E0
 1 64
36 hsa-miR-4679:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.667E-3 3.835E-2
2.477E-1
1.000E0
 1 69
37 hsa-miR-5590-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.860E-3 3.835E-2
2.477E-1
1.000E0
 1 71
38 CTCAAGA,MIR-526B:MSigDB CTCAAGA,MIR-526B:MSigDB MSigDB 6.956E-3 3.835E-2
2.477E-1
1.000E0
 1 72
39 hsa-miR-4677-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.149E-3 3.835E-2
2.477E-1
1.000E0
 1 74
40 hsa-miR-499b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.149E-3 3.835E-2
2.477E-1
1.000E0
 1 74
41 hsa-miR-374a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 3.835E-2
2.477E-1
1.000E0
 1 75
42 hsa-miR-6815-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.341E-3 3.835E-2
2.477E-1
1.000E0
 1 76
43 hsa-miR-6865-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.438E-3 3.835E-2
2.477E-1
1.000E0
 1 77
44 hsa-miR-379:PITA hsa-miR-379:PITA TOP PITA 7.438E-3 3.835E-2
2.477E-1
1.000E0
 1 77
45 hsa-miR-4732-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.534E-3 3.835E-2
2.477E-1
1.000E0
 1 78
46 hsa-miR-3943:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.534E-3 3.835E-2
2.477E-1
1.000E0
 1 78
47 hsa-miR-3688-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.630E-3 3.835E-2
2.477E-1
1.000E0
 1 79
48 hsa-miR-3529-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 3.835E-2
2.477E-1
1.000E0
 1 83
49 hsa-miR-135b-5p:Functional MTI Functional MTI miRTarbase 8.015E-3 3.835E-2
2.477E-1
1.000E0
 1 83
50 hsa-miR-769-5p:PITA hsa-miR-769-5p:PITA TOP PITA 8.015E-3 3.835E-2
2.477E-1
1.000E0
 1 83
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 2030 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000005263 lysosphingomyelin Stitch 1.178E-5 1.003E-2
8.221E-2
 2.392E-2 3 161
2 2167 DN Benzocaine [94-09-7]; Down 200; 24.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.222E-5 1.003E-2
8.221E-2
 4.511E-2 3 199
3 ctd:C007350 nitrofen CTD 3.791E-5 1.003E-2
8.221E-2
7.696E-2
 3 238
4 CID000002384 AC1L1DK5 Stitch 3.976E-5 1.003E-2
8.221E-2
8.071E-2
 2 32
5 ctd:D014800 Vitallium CTD 4.083E-5 1.003E-2
8.221E-2
8.289E-2
 3 244
6 CID000011178 zinc stearate Stitch 6.245E-5 1.003E-2
8.221E-2
1.268E-1
 2 40
7 CID000015625 dioxin Stitch 1.163E-4 1.003E-2
8.221E-2
2.360E-1
 3 347
8 CID000124013 Bouin's solution Stitch 1.509E-4 1.003E-2
8.221E-2
3.064E-1
 2 62
9 CID000079689 polyoxyethylene (10 Stitch 1.558E-4 1.003E-2
8.221E-2
3.164E-1
 2 63
10 CID000005526 tranexamic acid Stitch 1.608E-4 1.003E-2
8.221E-2
3.265E-1
 2 64
11 ctd:C000621033 napabucasin CTD 1.608E-4 1.003E-2
8.221E-2
3.265E-1
 2 64
12 CID000005372 NSC717865 Stitch 1.618E-4 1.003E-2
8.221E-2
3.285E-1
 3 388
13 CID009549240 3 tp Stitch 1.711E-4 1.003E-2
8.221E-2
3.473E-1
 2 66
14 CID000065947 prulifloxacin Stitch 1.925E-4 1.003E-2
8.221E-2
3.908E-1
 2 70
15 CID000005291 imatinib Stitch 2.192E-4 1.003E-2
8.221E-2
4.450E-1
 3 430
16 CID000015967 azar Stitch 2.210E-4 1.003E-2
8.221E-2
4.487E-1
 2 75
17 ctd:D003975 Diazepam CTD 2.210E-4 1.003E-2
8.221E-2
4.487E-1
 2 75
18 CID005282473 Zinostatino Stitch 2.391E-4 1.003E-2
8.221E-2
4.854E-1
 2 78
19 ctd:C064116 S-(1,1,2,2-tetrafluoroethyl)cysteine CTD 2.391E-4 1.003E-2
8.221E-2
4.854E-1
 2 78
20 ctd:C025340 manganese chloride CTD 2.640E-4 1.003E-2
8.221E-2
5.359E-1
 3 458
21 ctd:C084656 paricalcitol CTD 3.043E-4 1.003E-2
8.221E-2
6.178E-1
 2 88
22 DB03093 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
23 DB08557 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
24 DB07317 (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
25 DB03899 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
26 DB08787 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
27 DB06964 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
28 DB03504 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
29 DB06961 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
30 DB08436 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
31 DB07495 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
32 DB08442 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
33 DB08789 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
34 DB07601 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
35 DB08443 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
36 CID000122861 AC1L3VEN Stitch 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
37 DB02550 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
38 DB02359 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
39 DB07325 N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
40 DB08786 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
41 DB03749 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
42 DB03809 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
43 DB06956 N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
44 DB02840 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
45 DB07324 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
46 DB07100 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
47 CID000077692 2h PCA Stitch 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
48 DB08194 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
49 DB04505 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
50 DB07319 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE Drug Bank 3.065E-4 1.003E-2
8.221E-2
6.221E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 458 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C4022878 Descending aortic dissection DisGeNET Curated 1.245E-5 9.500E-4 6.370E-3 5.701E-3 2 13
2 C1836653 Ascending aortic dissection DisGeNET Curated 1.245E-5 9.500E-4 6.370E-3 5.701E-3 2 13
3 C2674574 Aortic aneurysm, familial thoracic 3 DisGeNET Curated 1.245E-5 9.500E-4 6.370E-3 5.701E-3 2 13
4 C1836635 Loeys-Dietz Aortic Aneurysm Syndrome DisGeNET Curated 1.245E-5 9.500E-4 6.370E-3 5.701E-3 2 13
5 C0392775 Cystic medial necrosis of aorta DisGeNET Curated 1.245E-5 9.500E-4 6.370E-3 5.701E-3 2 13
6 C4025845 Abnormality of the iris DisGeNET Curated 1.452E-5 9.500E-4 6.370E-3 6.650E-3 2 14
7 C0013405 Dyspnea, Paroxysmal DisGeNET Curated 1.452E-5 9.500E-4 6.370E-3 6.650E-3 2 14
8 C0553982 Impaired left ventricular function DisGeNET Curated 1.914E-5 1.096E-3 7.347E-3 8.765E-3 2 16
9 C0023212 Left-Sided Heart Failure DisGeNET Curated 2.726E-5 1.387E-3 9.300E-3 1.248E-2 2 19
10 C0231807 Dyspnea on exertion DisGeNET Curated 4.395E-5 2.013E-3 1.350E-2 2.013E-2 2 24
11 C0266122 Cleft uvula DisGeNET Curated 5.585E-5 2.326E-3 1.559E-2 2.558E-2 2 27
12 C0334533 Arteriovenous hemangioma DisGeNET BeFree 7.885E-5 2.551E-3 1.711E-2 3.611E-2 2 32
13 C0542514 Blue sclera DisGeNET Curated 8.392E-5 2.551E-3 1.711E-2 3.843E-2 2 33
14 C0241240 Tall stature DisGeNET Curated 8.914E-5 2.551E-3 1.711E-2 4.083E-2 2 34
15 C0263401 Cutis marmorata DisGeNET Curated 8.914E-5 2.551E-3 1.711E-2 4.083E-2 2 34
16 C0008479 Chondrosarcoma DisGeNET Curated 9.470E-5 2.551E-3 1.711E-2 4.337E-2 3 230
17 C1282496 Metastasis from malignant tumor of prostate DisGeNET BeFree 9.470E-5 2.551E-3 1.711E-2 4.337E-2 3 230
18 C0149630 Bicuspid aortic valve DisGeNET Curated 1.058E-4 2.648E-3 1.775E-2 4.844E-2 2 37
19 C0003504 Aortic Valve Insufficiency DisGeNET Curated 1.129E-4 2.648E-3 1.775E-2
5.169E-2
 3 244
20 C0936223 Metastatic Prostate Carcinoma DisGeNET BeFree 1.156E-4 2.648E-3 1.775E-2
5.296E-2
 3 246
21 C0039446 Telangiectasis DisGeNET Curated 1.238E-4 2.700E-3 1.810E-2
5.669E-2
 2 40
22 C0856169 Endothelial dysfunction DisGeNET BeFree 1.410E-4 2.934E-3 1.968E-2
6.456E-2
 3 263
23 C0003706 Arachnodactyly DisGeNET Curated 1.863E-4 3.710E-3 2.487E-2
8.532E-2
 2 49
24 C0008031 Chest Pain DisGeNET Curated 2.436E-4 4.038E-3 2.707E-2
1.116E-1
 2 56
25 C0158646 Cleft palate with cleft lip DisGeNET Curated 2.524E-4 4.038E-3 2.707E-2
1.156E-1
 2 57
26 C0003857 Congenital arteriovenous malformation DisGeNET Curated 2.892E-4 4.038E-3 2.707E-2
1.324E-1
 2 61
27 C0011389 Dental Plaque DisGeNET BeFree 2.892E-4 4.038E-3 2.707E-2
1.324E-1
 2 61
28 C0042133 Uterine Fibroids DisGeNET Curated 3.089E-4 4.038E-3 2.707E-2
1.415E-1
 3 343
29 C0264133 Acquired flat foot DisGeNET Curated 4.142E-4 4.038E-3 2.707E-2
1.897E-1
 2 73
30 C0016202 Flatfoot DisGeNET Curated 4.142E-4 4.038E-3 2.707E-2
1.897E-1
 2 73
31 OMIN:107970 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1; ARVD1 OMIM 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
32 C0033740 Protozoan Infections DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
33 C4083047 MULTIPLE SELF-HEALING SQUAMOUS EPITHELIOMA, SUSCEPTIBILITY TO DisGeNET Curated 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
34 C0684550 Secondary malignant neoplasm of vertebral column DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
35 C0264969 Aneurysm of celiac artery DisGeNET Curated 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
36 OMIN:187300 TELANGIECTASIA, HEREDITARY HEMORRHAGIC, OF RENDU, OSLER, AND WEBER; HHT OMIM 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
37 C4225631 HEREDITARY HEMORRHAGIC TELANGIECTASIA 1 DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
38 C4023119 Mesenteric artery aneurysm DisGeNET Curated 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
39 C1857692 Venous varicosities of celiac and mesenteric vessels DisGeNET Curated 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
40 C0276871 Infection by Trypanosoma evansi DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
41 C3825353 Protozoan diseases DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
42 C1862511 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 1 (disorder) DisGeNET Curated 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
43 cv:C0039445 Osler hemorrhagic telangiectasia syndrome Clinical Variations 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
44 cv:CN182633 Rienhoff syndrome Clinical Variations 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
45 C0302883 SMITH DISEASE DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
46 C4086114 Canine Mammary Carcinoma DisGeNET BeFree 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
47 C0742747 High-output congestive heart failure DisGeNET Curated 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
48 cv:C1862511 Arrhythmogenic right ventricular cardiomyopathy, type 1 Clinical Variations 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
49 cv:C0546476 Multiple self healing squamous epithelioma Clinical Variations 4.320E-4 4.038E-3 2.707E-2
1.978E-1
 1 1
50 C0162810 Cicatrix, Hypertrophic DisGeNET BeFree 4.490E-4 4.112E-3 2.757E-2
2.056E-1
 2 76
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