Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc95_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003684 damaged DNA binding 6.684E-10 1.671E-8 6.377E-8 1.671E-8 4 65
2 GO:0003697 single-stranded DNA binding 4.532E-9 5.665E-8 2.162E-7 1.133E-7 4 104
3 GO:0001094 TFIID-class transcription factor complex binding 1.206E-6 6.697E-6 2.555E-5 3.014E-5 2 7
4 GO:0004520 endodeoxyribonuclease activity 1.229E-6 6.697E-6 2.555E-5 3.072E-5 3 94
5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1.607E-6 6.697E-6 2.555E-5 4.018E-5 2 8
6 GO:0001091 RNA polymerase II basal transcription factor binding 1.607E-6 6.697E-6 2.555E-5 4.018E-5 2 8
7 GO:0004536 deoxyribonuclease activity 1.922E-6 6.865E-6 2.620E-5 4.805E-5 3 109
8 GO:0004519 endonuclease activity 6.948E-6 2.171E-5 8.285E-5 1.737E-4 3 167
9 GO:0004518 nuclease activity 1.815E-5 4.921E-5 1.878E-4 4.537E-4 3 230
10 GO:0001098 basal transcription machinery binding 2.165E-5 4.921E-5 1.878E-4 5.413E-4 2 28
11 GO:0001099 basal RNA polymerase II transcription machinery binding 2.165E-5 4.921E-5 1.878E-4 5.413E-4 2 28
12 GO:0044823 retroviral integrase activity 8.173E-5 1.362E-4 5.198E-4 2.043E-3 2 54
13 GO:0008907 integrase activity 8.173E-5 1.362E-4 5.198E-4 2.043E-3 2 54
14 GO:0044824 retroviral 3' processing activity 8.173E-5 1.362E-4 5.198E-4 2.043E-3 2 54
15 GO:0043765 T/G mismatch-specific endonuclease activity 8.173E-5 1.362E-4 5.198E-4 2.043E-3 2 54
16 GO:0047485 protein N-terminus binding 3.850E-4 5.758E-4 2.197E-3 9.624E-3 2 117
17 GO:0001085 RNA polymerase II transcription factor binding 3.916E-4 5.758E-4 2.197E-3 9.789E-3 2 118
18 GO:0008022 protein C-terminus binding 1.401E-3 1.945E-3 7.424E-3 3.502E-2 2 224
19 GO:0000405 bubble DNA binding 1.874E-3 2.466E-3 9.411E-3 4.686E-2 1 7
20 GO:0042578 phosphoric ester hydrolase activity 5.036E-3 6.295E-3 2.402E-2
1.259E-1
 2 429
21 GO:0017025 TBP-class protein binding 6.148E-3 7.319E-3 2.793E-2
1.537E-1
 1 23
22 GO:0000217 DNA secondary structure binding 6.681E-3 7.592E-3 2.897E-2
1.670E-1
 1 25
23 GO:0031593 polyubiquitin modification-dependent protein binding 1.227E-2 1.333E-2
5.088E-2
3.066E-1
 1 46
24 GO:0043130 ubiquitin binding 2.861E-2 2.980E-2
1.137E-1
7.152E-1
 1 108
25 GO:0032182 ubiquitin-like protein binding 3.357E-2 3.357E-2
1.281E-1
8.393E-1
 1 127
Show 20 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 130 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006293 nucleotide-excision repair, preincision complex stabilization 5.969E-12 3.880E-10 2.114E-9 7.759E-10 4 21
2 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion 5.969E-12 3.880E-10 2.114E-9 7.759E-10 4 21
3 GO:0006289 nucleotide-excision repair 9.789E-12 4.242E-10 2.311E-9 1.273E-9 5 119
4 GO:0070911 global genome nucleotide-excision repair 3.584E-11 1.165E-9 6.347E-9 4.660E-9 4 32
5 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 6.582E-11 1.711E-9 9.324E-9 8.556E-9 4 37
6 GO:0033683 nucleotide-excision repair, DNA incision 8.196E-11 1.776E-9 9.676E-9 1.066E-8 4 39
7 GO:0006283 transcription-coupled nucleotide-excision repair 1.083E-9 2.011E-8 1.096E-7 1.408E-7 4 73
8 GO:0009650 UV protection 2.043E-9 3.319E-8 1.808E-7 2.655E-7 3 12
9 GO:0009411 response to UV 1.521E-8 2.197E-7 1.197E-6 1.977E-6 4 140
10 GO:0006294 nucleotide-excision repair, preincision complex assembly 3.388E-8 4.404E-7 2.400E-6 4.404E-6 3 29
11 GO:1901255 nucleotide-excision repair involved in interstrand cross-link repair 5.767E-8 6.816E-7 3.714E-6 7.497E-6 2 2
12 GO:0031334 positive regulation of protein complex assembly 1.084E-7 1.174E-6 6.397E-6 1.409E-5 4 228
13 GO:0036297 interstrand cross-link repair 1.226E-7 1.226E-6 6.683E-6 1.594E-5 3 44
14 GO:0090305 nucleic acid phosphodiester bond hydrolysis 2.201E-7 2.043E-6 1.113E-5 2.861E-5 4 272
15 GO:0009416 response to light stimulus 5.193E-7 4.501E-6 2.452E-5 6.751E-5 4 337
16 GO:0043254 regulation of protein complex assembly 1.031E-6 8.375E-6 4.563E-5 1.340E-4 4 400
17 GO:0044089 positive regulation of cellular component biogenesis 1.695E-6 1.296E-5 7.061E-5 2.203E-4 4 453
18 GO:0009314 response to radiation 2.135E-6 1.542E-5 8.403E-5 2.776E-4 4 480
19 GO:0035264 multicellular organism growth 8.755E-6 5.990E-5 3.264E-4 1.138E-3 3 180
20 GO:0000717 nucleotide-excision repair, DNA duplex unwinding 1.329E-5 8.641E-5 4.708E-4 1.728E-3 2 22
21 GO:0000715 nucleotide-excision repair, DNA damage recognition 1.456E-5 9.012E-5 4.910E-4 1.893E-3 2 23
22 GO:0065004 protein-DNA complex assembly 1.709E-5 1.010E-4 5.504E-4 2.222E-3 3 225
23 GO:0032205 negative regulation of telomere maintenance 1.869E-5 1.057E-4 5.757E-4 2.430E-3 2 26
24 GO:0071824 protein-DNA complex subunit organization 2.400E-5 1.300E-4 7.083E-4 3.120E-3 3 252
25 GO:0010259 multicellular organism aging 3.419E-5 1.778E-4 9.688E-4 4.445E-3 2 35
26 GO:0032204 regulation of telomere maintenance 1.304E-4 6.522E-4 3.554E-3 1.696E-2 2 68
27 GO:0034644 cellular response to UV 1.504E-4 7.242E-4 3.946E-3 1.955E-2 2 73
28 GO:0032508 DNA duplex unwinding 1.631E-4 7.571E-4 4.125E-3 2.120E-2 2 76
29 GO:0032392 DNA geometric change 1.853E-4 8.305E-4 4.525E-3 2.409E-2 2 81
30 GO:0051053 negative regulation of DNA metabolic process 3.735E-4 1.618E-3 8.818E-3 4.855E-2 2 115
31 GO:2001251 negative regulation of chromosome organization 3.865E-4 1.621E-3 8.832E-3
5.025E-2
 2 117
32 GO:0071482 cellular response to light stimulus 4.066E-4 1.652E-3 8.999E-3
5.285E-2
 2 120
33 GO:0000723 telomere maintenance 5.529E-4 2.178E-3 1.187E-2
7.187E-2
 2 140
34 GO:0032200 telomere organization 6.598E-4 2.523E-3 1.375E-2
8.577E-2
 2 153
35 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair 8.053E-4 2.991E-3 1.630E-2
1.047E-1
 1 3
36 GO:0071478 cellular response to radiation 8.327E-4 3.007E-3 1.638E-2
1.083E-1
 2 172
37 GO:1904431 positive regulation of t-circle formation 1.074E-3 3.692E-3 2.012E-2
1.396E-1
 1 4
38 GO:0006302 double-strand break repair 1.079E-3 3.692E-3 2.012E-2
1.403E-1
 2 196
39 GO:0035166 post-embryonic hemopoiesis 1.610E-3 5.233E-3 2.851E-2
2.093E-1
 1 6
40 GO:0001302 replicative cell aging 1.610E-3 5.233E-3 2.851E-2
2.093E-1
 1 6
41 GO:1904429 regulation of t-circle formation 1.878E-3 5.955E-3 3.245E-2
2.442E-1
 1 7
42 GO:0006310 DNA recombination 1.990E-3 6.066E-3 3.305E-2
2.587E-1
 2 267
43 GO:0006290 pyrimidine dimer repair 2.146E-3 6.066E-3 3.305E-2
2.790E-1
 1 8
44 GO:0090656 t-circle formation 2.146E-3 6.066E-3 3.305E-2
2.790E-1
 1 8
45 GO:0034285 response to disaccharide 2.146E-3 6.066E-3 3.305E-2
2.790E-1
 1 8
46 GO:0009744 response to sucrose 2.146E-3 6.066E-3 3.305E-2
2.790E-1
 1 8
47 GO:0071103 DNA conformation change 2.264E-3 6.262E-3 3.412E-2
2.943E-1
 2 285
48 GO:0033044 regulation of chromosome organization 2.521E-3 6.706E-3 3.654E-2
3.278E-1
 2 301
49 GO:0007568 aging 2.638E-3 6.706E-3 3.654E-2
3.429E-1
 2 308
50 GO:0071214 cellular response to abiotic stimulus 2.638E-3 6.706E-3 3.654E-2
3.429E-1
 2 308
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 29 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000109 nucleotide-excision repair complex 9.099E-13 2.639E-11 1.045E-10 2.639E-11 4 14
2 GO:0000110 nucleotide-excision repair factor 1 complex 8.665E-12 1.256E-10 4.978E-10 2.513E-10 3 3
3 GO:1990391 DNA repair complex 1.481E-10 1.432E-9 5.673E-9 4.296E-9 4 46
4 GO:0070522 ERCC4-ERCC1 complex 1.651E-7 1.197E-6 4.743E-6 4.789E-6 2 3
5 GO:0016591 RNA polymerase II, holoenzyme 1.308E-6 7.587E-6 3.006E-5 3.794E-5 3 98
6 GO:0090575 RNA polymerase II transcription factor complex 1.611E-6 7.788E-6 3.085E-5 4.673E-5 3 105
7 GO:0000428 DNA-directed RNA polymerase complex 2.472E-6 8.577E-6 3.398E-5 7.170E-5 3 121
8 GO:0055029 nuclear DNA-directed RNA polymerase complex 2.472E-6 8.577E-6 3.398E-5 7.170E-5 3 121
9 GO:0030880 RNA polymerase complex 2.662E-6 8.577E-6 3.398E-5 7.719E-5 3 124
10 GO:0044798 nuclear transcription factor complex 3.363E-6 9.751E-6 3.863E-5 9.751E-5 3 134
11 GO:0005662 DNA replication factor A complex 6.596E-6 1.739E-5 6.889E-5 1.913E-4 2 16
12 GO:0005669 transcription factor TFIID complex 1.390E-5 3.358E-5 1.331E-4 4.030E-4 2 23
13 GO:0061695 transferase complex, transferring phosphorus-containing groups 2.033E-5 4.299E-5 1.703E-4 5.896E-4 3 244
14 GO:0043601 nuclear replisome 2.075E-5 4.299E-5 1.703E-4 6.018E-4 2 28
15 GO:0030894 replisome 2.552E-5 4.934E-5 1.955E-4 7.401E-4 2 31
16 GO:0043596 nuclear replication fork 4.496E-5 8.148E-5 3.228E-4 1.304E-3 2 41
17 GO:0005667 transcription factor complex 6.935E-5 1.183E-4 4.687E-4 2.011E-3 3 368
18 GO:0005657 replication fork 1.209E-4 1.948E-4 7.716E-4 3.506E-3 2 67
19 GO:0000784 nuclear chromosome, telomeric region 4.766E-4 7.275E-4 2.882E-3 1.382E-2 2 133
20 GO:0000781 chromosome, telomeric region 7.059E-4 1.024E-3 4.055E-3 2.047E-2 2 162
21 GO:0071942 XPC complex 7.868E-4 1.087E-3 4.304E-3 2.282E-2 1 3
22 GO:0032993 protein-DNA complex 8.995E-4 1.186E-3 4.697E-3 2.608E-2 2 183
23 GO:0098687 chromosomal region 3.133E-3 3.950E-3 1.565E-2
9.085E-2
 2 344
24 GO:0005675 transcription factor TFIIH holo complex 3.406E-3 4.115E-3 1.630E-2
9.877E-2
 1 13
25 GO:0032806 carboxy-terminal domain protein kinase complex 6.019E-3 6.982E-3 2.766E-2
1.746E-1
 1 23
26 GO:0045171 intercellular bridge 1.149E-2 1.282E-2
5.077E-2
3.332E-1
 1 44
27 GO:0000502 proteasome complex 2.030E-2 2.180E-2
8.636E-2
5.886E-1
 1 78
28 GO:1902554 serine/threonine protein kinase complex 2.107E-2 2.182E-2
8.645E-2
6.110E-1
 1 81
29 GO:1902911 protein kinase complex 2.390E-2 2.390E-2
9.470E-2
6.932E-1
 1 92
Show 24 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 538 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003079 Defective DNA repair after ultraviolet radiation damage 1.289E-8 2.311E-6 1.587E-5 6.932E-6 3 8
2 HP:0010649 Flat nasal alae 1.289E-8 2.311E-6 1.587E-5 6.932E-6 3 8
3 HP:0007606 Multiple cutaneous malignancies 1.289E-8 2.311E-6 1.587E-5 6.932E-6 3 8
4 HP:0009755 Ankyloblepharon 6.575E-8 8.844E-6 6.072E-5 3.538E-5 3 13
5 HP:0007537 Severe photosensitivity 1.562E-7 1.681E-5 1.154E-4 8.406E-5 3 17
6 HP:0000621 Entropion 3.536E-7 2.797E-5 1.920E-4 1.902E-4 3 22
7 HP:0000524 Conjunctival telangiectasia 4.065E-7 2.797E-5 1.920E-4 2.187E-4 3 23
8 HP:0000992 Cutaneous photosensitivity 4.159E-7 2.797E-5 1.920E-4 2.237E-4 4 121
9 HP:0008054 Abnormal vasculature of the conjunctiva morphology 5.278E-7 3.155E-5 2.166E-4 2.839E-4 3 25
10 HP:0001029 Poikiloderma 6.710E-7 3.610E-5 2.479E-4 3.610E-4 3 27
11 HP:0006887 Intellectual disability, progressive 9.654E-7 4.369E-5 3.000E-4 5.194E-4 4 149
12 HP:0004493 Craniofacial hyperostosis 1.030E-6 4.369E-5 3.000E-4 5.544E-4 3 31
13 HP:0001059 Pterygium 1.137E-6 4.369E-5 3.000E-4 6.117E-4 3 32
14 HP:0011133 Increased sensitivity to ionizing radiation 1.137E-6 4.369E-5 3.000E-4 6.117E-4 3 32
15 HP:0003254 Abnormality of DNA repair 1.371E-6 4.918E-5 3.377E-4 7.377E-4 3 34
16 HP:0100579 Mucosal telangiectasiae 2.092E-6 6.760E-5 4.641E-4 1.126E-3 3 39
17 HP:0004437 Cranial hyperostosis 2.262E-6 6.760E-5 4.641E-4 1.217E-3 3 40
18 HP:0011018 Abnormality of the cell cycle 2.262E-6 6.760E-5 4.641E-4 1.217E-3 3 40
19 HP:0004330 Increased skull ossification 3.246E-6 8.739E-5 6.000E-4 1.746E-3 3 45
20 HP:0007587 Numerous pigmented freckles 3.249E-6 8.739E-5 6.000E-4 1.748E-3 2 4
21 HP:0000498 Blepharitis 3.708E-6 9.499E-5 6.522E-4 1.995E-3 3 47
22 HP:0002299 Brittle hair 4.480E-6 1.048E-4 7.195E-4 2.410E-3 3 50
23 HP:0100774 Hyperostosis 4.480E-6 1.048E-4 7.195E-4 2.410E-3 3 50
24 HP:0003220 Abnormality of chromosome stability 4.759E-6 1.067E-4 7.325E-4 2.560E-3 3 51
25 HP:0000656 Ectropion 5.991E-6 1.276E-4 8.763E-4 3.223E-3 3 55
26 HP:0002120 Cerebral cortical atrophy 6.168E-6 1.276E-4 8.763E-4 3.318E-3 4 236
27 HP:0001480 Freckling 7.043E-6 1.403E-4 9.636E-4 3.789E-3 3 58
28 HP:0000995 Melanocytic nevus 1.043E-5 1.972E-4 1.354E-3 5.612E-3 3 66
29 HP:0002344 Progressive neurologic deterioration 1.092E-5 1.972E-4 1.354E-3 5.874E-3 3 67
30 HP:0012740 Papilloma 1.142E-5 1.972E-4 1.354E-3 6.145E-3 3 68
31 HP:0100585 Telangiectasia of the skin 1.142E-5 1.972E-4 1.354E-3 6.145E-3 3 68
32 HP:0004431 Complement deficiency 1.194E-5 1.972E-4 1.354E-3 6.423E-3 3 69
33 HP:0002750 Delayed skeletal maturation 1.210E-5 1.972E-4 1.354E-3 6.507E-3 4 279
34 HP:0002703 Abnormality of skull ossification 1.600E-5 2.532E-4 1.738E-3 8.608E-3 3 76
35 HP:0000963 Thin skin 1.665E-5 2.559E-4 1.757E-3 8.956E-3 3 77
36 HP:0002916 Abnormality of chromosome segregation 1.799E-5 2.688E-4 1.846E-3 9.678E-3 3 79
37 HP:0001025 Urticaria 2.166E-5 3.149E-4 2.162E-3 1.165E-2 3 84
38 HP:0000927 Abnormality of skeletal maturation 2.234E-5 3.163E-4 2.172E-3 1.202E-2 4 325
39 HP:0002671 Basal cell carcinoma 2.408E-5 3.322E-4 2.281E-3 1.296E-2 3 87
40 HP:0004334 Dermal atrophy 2.945E-5 3.962E-4 2.720E-3 1.585E-2 3 93
41 HP:0007759 Opacification of the corneal stroma 3.042E-5 3.992E-4 2.741E-3 1.637E-2 3 94
42 HP:0011492 Abnormality of corneal stroma 3.241E-5 4.089E-4 2.808E-3 1.744E-2 3 96
43 HP:0000135 Hypogonadism 3.332E-5 4.089E-4 2.808E-3 1.792E-2 4 359
44 HP:0100726 Kaposi's sarcoma 3.344E-5 4.089E-4 2.808E-3 1.799E-2 3 97
45 HP:0000491 Keratitis 3.449E-5 4.124E-4 2.832E-3 1.856E-2 3 98
46 HP:0002353 EEG abnormality 3.600E-5 4.211E-4 2.891E-3 1.937E-2 4 366
47 HP:0002213 Fine hair 4.008E-5 4.587E-4 3.150E-3 2.156E-2 3 103
48 HP:0005339 Abnormality of complement system 4.753E-5 5.327E-4 3.657E-3 2.557E-2 3 109
49 HP:0005353 Recurrent herpes 5.732E-5 6.293E-4 4.321E-3 3.084E-2 3 116
50 HP:0001315 Reduced tendon reflexes 6.257E-5 6.732E-4 4.622E-3 3.366E-2 4 420
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 348 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008058 abnormal DNA repair 1.003E-7 3.489E-5 2.244E-4 3.489E-5 4 125
2 MP:0001191 abnormal skin condition 2.150E-6 3.741E-4 2.406E-3 7.482E-4 4 268
3 MP:0004201 fetal growth retardation 1.313E-5 1.523E-3 9.795E-3 4.569E-3 3 115
4 MP:0004501 increased incidence of tumors by UV-induction 1.954E-5 1.700E-3 1.093E-2 6.799E-3 2 15
5 MP:0000607 abnormal hepatocyte morphology 4.628E-5 3.019E-3 1.941E-2 1.611E-2 3 175
6 MP:0008943 increased sensitivity to induced cell death 5.204E-5 3.019E-3 1.941E-2 1.811E-2 3 182
7 MP:0008410 increased cellular sensitivity to ultraviolet irradiation 8.626E-5 4.259E-3 2.739E-2 3.002E-2 2 31
8 MP:0005323 dystonia 9.790E-5 4.259E-3 2.739E-2 3.407E-2 2 33
9 MP:0008987 abnormal liver lobule morphology 1.218E-4 4.502E-3 2.895E-2 4.238E-2 3 242
10 MP:0008986 abnormal liver parenchyma morphology 1.423E-4 4.502E-3 2.895E-2 4.952E-2 3 255
11 MP:0008942 abnormal induced cell death 1.423E-4 4.502E-3 2.895E-2 4.952E-2 3 255
12 MP:0008412 increased cellular sensitivity to oxidative stress 1.914E-4 5.552E-3 3.570E-2
6.662E-2
 2 46
13 MP:0001199 thin skin 2.174E-4 5.819E-3 3.742E-2
7.565E-2
 2 49
14 MP:0004197 abnormal fetal growth/weight/body size 2.590E-4 6.438E-3 4.140E-2
9.013E-2
 3 312
15 MP:0011083 lethality at weaning, complete penetrance 3.952E-4 9.169E-3
5.896E-2
1.375E-1
 2 66
16 MP:0003786 premature aging 4.704E-4 1.023E-2
6.579E-2
1.637E-1
 2 72
17 MP:0004142 abnormal muscle tone 7.345E-4 1.504E-2
9.669E-2
2.556E-1
 2 90
18 MP:0005653 phototoxicity 9.655E-4 1.867E-2
1.200E-1
3.360E-1
 1 2
19 MP:0008569 lethality at weaning 1.037E-3 1.871E-2
1.203E-1
3.607E-1
 2 107
20 MP:0011750 abnormal seminiferous tubule epithelium morphology 1.075E-3 1.871E-2
1.203E-1
3.743E-1
 2 109
21 MP:0030003 hippocampus atrophy 1.930E-3 3.053E-2
1.964E-1
6.717E-1
 1 4
22 MP:0000548 long limbs 1.930E-3 3.053E-2
1.964E-1
6.717E-1
 1 4
23 MP:0006167 eyelid edema 2.412E-3 3.588E-2
2.308E-1
8.395E-1
 1 5
24 MP:0002021 increased incidence of induced tumors 2.475E-3 3.588E-2
2.308E-1
8.612E-1
 2 166
25 MP:0002879 increased cellular sensitivity to X-ray irradiation 2.894E-3 3.874E-2
2.491E-1
1.000E0
 1 6
26 MP:0020427 increased hepatocyte karyomegaly 2.894E-3 3.874E-2
2.491E-1
1.000E0
 1 6
27 MP:0003111 abnormal cell nucleus morphology 3.330E-3 4.196E-2
2.698E-1
1.000E0
 2 193
28 MP:0013705 decreased megakaryocyte-erythroid progenitor cell number 3.376E-3 4.196E-2
2.698E-1
1.000E0
 1 7
29 MP:0001349 excessive tearing 3.858E-3 4.414E-2
2.839E-1
1.000E0
 1 8
30 MP:0000478 delayed intestine development 4.339E-3 4.414E-2
2.839E-1
1.000E0
 1 9
31 MP:0013703 abnormal megakaryocyte-erythroid progenitor cell number 4.339E-3 4.414E-2
2.839E-1
1.000E0
 1 9
32 MP:0001788 periorbital edema 4.339E-3 4.414E-2
2.839E-1
1.000E0
 1 9
33 MP:0000601 small liver 4.385E-3 4.414E-2
2.839E-1
1.000E0
 2 222
34 MP:0000160 kyphosis 4.780E-3 4.414E-2
2.839E-1
1.000E0
 2 232
35 MP:0009796 abnormal base-excision repair 4.820E-3 4.414E-2
2.839E-1
1.000E0
 1 10
36 MP:0010699 dilated hair follicles 4.820E-3 4.414E-2
2.839E-1
1.000E0
 1 10
37 MP:0009859 eye opacity 4.820E-3 4.414E-2
2.839E-1
1.000E0
 1 10
38 MP:0013702 abnormal megakaryocyte-erythroid progenitor cell morphology 4.820E-3 4.414E-2
2.839E-1
1.000E0
 1 10
39 MP:0002628 hepatic steatosis 5.192E-3 4.500E-2
2.894E-1
1.000E0
 2 242
40 MP:0003325 decreased liver function 5.301E-3 4.500E-2
2.894E-1
1.000E0
 1 11
41 MP:0013551 decreased cerebellar granule cell precursor proliferation 5.301E-3 4.500E-2
2.894E-1
1.000E0
 1 11
42 MP:0013151 abnormal incidence of induced tumors 5.533E-3 4.573E-2
2.941E-1
1.000E0
 2 250
43 MP:0011174 lipodystrophy 5.782E-3 4.573E-2
2.941E-1
1.000E0
 1 12
44 MP:0013697 decreased granulocyte monocyte progenitor cell number 5.782E-3 4.573E-2
2.941E-1
1.000E0
 1 12
45 MP:0009703 decreased birth body size 5.974E-3 4.620E-2
2.971E-1
1.000E0
 2 260
46 MP:0009701 abnormal birth body size 6.109E-3 4.621E-2
2.972E-1
1.000E0
 2 263
47 MP:0001203 increased sensitivity to skin irradiation 6.263E-3 4.637E-2
2.982E-1
1.000E0
 1 13
48 MP:0009968 abnormal cerebellar granule cell precursor proliferation 6.743E-3 4.693E-2
3.018E-1
1.000E0
 1 14
49 MP:0030038 abnormal periorbital region morphology 6.743E-3 4.693E-2
3.018E-1
1.000E0
 1 14
50 MP:0008411 decreased cellular sensitivity to ultraviolet irradiation 6.743E-3 4.693E-2
3.018E-1
1.000E0
 1 14
Show 45 more annotations

6: Domain [Display Chart] 5 input genes in category / 57 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR011335 Restrct endonuc-II-like InterPro 5.696E-7 3.247E-5 1.503E-4 3.247E-5 2 5
2 IPR010994 RuvA 2-like InterPro 2.050E-6 5.842E-5 2.704E-4 1.168E-4 2 9
3 PF05181 XPA C Pfam 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
4 IPR000465 XPA InterPro 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
5 PS00752 XPA 1 PROSITE 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
6 IPR022652 Znf XPA CS InterPro 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
7 IPR022658 XPA CS InterPro 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
8 IPR006167 XPF InterPro 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
9 IPR004579 ERCC1/RAD10/SWI10 InterPro 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
10 PF01286 XPA N Pfam 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
11 IPR001044 XPG/Rad2 eukaryotes InterPro 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
12 PS00753 XPA 2 PROSITE 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
13 PD013585 DNA repair Rad10 ProDom 2.669E-4 1.170E-3 5.417E-3 1.521E-2 1 1
14 1.10.10.540 - Gene3D 5.337E-4 1.601E-3 7.412E-3 3.042E-2 1 2
15 IPR022656 XPA C InterPro 5.337E-4 1.601E-3 7.412E-3 3.042E-2 1 2
16 IPR015360 XPC-bd InterPro 5.337E-4 1.601E-3 7.412E-3 3.042E-2 1 2
17 3.90.530.10 - Gene3D 5.337E-4 1.601E-3 7.412E-3 3.042E-2 1 2
18 PF09280 XPC-binding Pfam 5.337E-4 1.601E-3 7.412E-3 3.042E-2 1 2
19 IPR004806 Rad23 InterPro 5.337E-4 1.601E-3 7.412E-3 3.042E-2 1 2
20 IPR020819 DNA repair nuc XPF/helicase InterPro 8.005E-4 1.901E-3 8.799E-3 4.563E-2 1 3
21 3.40.50.10130 - Gene3D 8.005E-4 1.901E-3 8.799E-3 4.563E-2 1 3
22 IPR019974 XPG CS InterPro 8.005E-4 1.901E-3 8.799E-3 4.563E-2 1 3
23 SM00279 HhH2 SMART 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
24 IPR006086 XPG-I dom InterPro 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
25 PF00867 XPG I Pfam 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
26 SM00485 XPGN SMART 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
27 IPR020045 5-3 exonuclease C InterPro 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
28 IPR006084 XPG/Rad2 InterPro 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
29 PS00842 XPG 2 PROSITE 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
30 PS00841 XPG 1 PROSITE 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
31 IPR008918 HhH2 InterPro 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
32 SM00484 XPGI SMART 1.067E-3 1.901E-3 8.799E-3
6.083E-2
 1 4
33 IPR006166 ERCC4 domain InterPro 1.334E-3 2.055E-3 9.512E-3
7.603E-2
 1 5
34 IPR006085 XPG DNA repair N InterPro 1.334E-3 2.055E-3 9.512E-3
7.603E-2
 1 5
35 PF00752 XPG N Pfam 1.334E-3 2.055E-3 9.512E-3
7.603E-2
 1 5
36 PF02732 ERCC4 Pfam 1.334E-3 2.055E-3 9.512E-3
7.603E-2
 1 5
37 SM00891 ERCC4 SMART 1.334E-3 2.055E-3 9.512E-3
7.603E-2
 1 5
38 PF00633 HHH Pfam 1.867E-3 2.596E-3 1.201E-2
1.064E-1
 1 7
39 IPR000445 HhH motif InterPro 1.867E-3 2.596E-3 1.201E-2
1.064E-1
 1 7
40 IPR003583 Hlx-hairpin-Hlx DNA-bd motif InterPro 1.867E-3 2.596E-3 1.201E-2
1.064E-1
 1 7
41 SM00278 HhH1 SMART 1.867E-3 2.596E-3 1.201E-2
1.064E-1
 1 7
42 SM00727 STI1 SMART 2.666E-3 3.534E-3 1.636E-2
1.520E-1
 1 10
43 IPR006636 STI1 HS-bd InterPro 2.666E-3 3.534E-3 1.636E-2
1.520E-1
 1 10
44 IPR009061 DNA-bd dom put InterPro 2.933E-3 3.799E-3 1.759E-2
1.672E-1
 1 11
45 3.40.50.1010 - Gene3D 3.199E-3 4.052E-3 1.876E-2
1.823E-1
 1 12
46 IPR029060 PIN domain-like InterPro 3.731E-3 4.623E-3 2.140E-2
2.127E-1
 1 14
47 SM00165 UBA SMART 7.982E-3 9.680E-3 4.481E-2
4.550E-1
 1 30
48 PF00627 UBA Pfam 9.572E-3 1.137E-2
5.262E-2
5.456E-1
 1 36
49 PS00299 UBIQUITIN 1 PROSITE 9.837E-3 1.144E-2
5.297E-2
5.607E-1
 1 37
50 SM00213 UBQ SMART 1.142E-2 1.302E-2
6.029E-2
6.512E-1
 1 43
Show 45 more annotations

7: Pathway [Display Chart] 5 input genes in category / 22 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1309114 Formation of Incision Complex in GG-NER BioSystems: REACTOME 3.865E-13 6.775E-12 2.500E-11 8.503E-12 5 43
2 83044 Nucleotide excision repair BioSystems: KEGG 6.159E-13 6.775E-12 2.500E-11 1.355E-11 5 47
3 1309112 Global Genome Nucleotide Excision Repair (GG-NER) BioSystems: REACTOME 1.317E-11 9.658E-11 3.565E-10 2.897E-10 5 85
4 1309111 Nucleotide Excision Repair BioSystems: REACTOME 5.386E-11 2.962E-10 1.093E-9 1.185E-9 5 112
5 1309115 Dual Incision in GG-NER BioSystems: REACTOME 5.048E-10 2.221E-9 8.199E-9 1.111E-8 4 41
6 1309119 Dual incision in TC-NER BioSystems: REACTOME 3.587E-9 1.315E-8 4.854E-8 7.892E-8 4 66
7 1309117 Transcription-Coupled Nucleotide Excision Repair (TC-NER) BioSystems: REACTOME 7.472E-9 2.348E-8 8.667E-8 1.644E-7 4 79
8 1270350 DNA Repair BioSystems: REACTOME 1.071E-8 2.945E-8 1.087E-7 2.356E-7 5 319
9 1309108 HDR through Single Strand Annealing (SSA) BioSystems: REACTOME 9.019E-5 2.201E-4 8.123E-4 1.984E-3 2 38
10 1309121 Fanconi Anemia Pathway BioSystems: REACTOME 1.000E-4 2.201E-4 8.123E-4 2.201E-3 2 40
11 377262 Fanconi anemia pathway BioSystems: KEGG 1.900E-4 3.800E-4 1.402E-3 4.180E-3 2 55
12 1404797 Platinum drug resistance BioSystems: KEGG 3.353E-4 6.147E-4 2.269E-3 7.376E-3 2 73
13 1309100 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) BioSystems: REACTOME 1.126E-3 1.905E-3 7.031E-3 2.477E-2 2 134
14 1309099 Homology Directed Repair BioSystems: REACTOME 1.228E-3 1.930E-3 7.122E-3 2.702E-2 2 140
15 1309095 DNA Double-Strand Break Repair BioSystems: REACTOME 1.783E-3 2.615E-3 9.653E-3 3.923E-2 2 169
16 1427864 Josephin domain DUBs BioSystems: REACTOME 4.811E-3 6.615E-3 2.441E-2
1.058E-1
 1 12
17 1268722 N-glycan trimming in the ER and Calnexin/Calreticulin cycle BioSystems: REACTOME 1.438E-2 1.861E-2
6.867E-2
3.163E-1
 1 36
18 1309113 DNA Damage Recognition in GG-NER BioSystems: REACTOME 1.557E-2 1.903E-2
7.022E-2
3.425E-1
 1 39
19 1309118 Formation of TC-NER Pre-Incision Complex BioSystems: REACTOME 2.150E-2 2.490E-2
9.189E-2
4.731E-1
 1 54
Show 14 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 1351 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11259578 Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome. Pubmed 6.824E-19 9.219E-16 7.178E-15 9.219E-16 5 11
2 10214908 DNA damage recognition during nucleotide excision repair in mammalian cells. Pubmed 2.290E-17 1.547E-14 1.204E-13 3.094E-14 5 20
3 10583946 Quality control by DNA repair. Pubmed 1.452E-16 6.537E-14 5.090E-13 1.961E-13 5 28
4 19029193 Red meat and poultry intake, polymorphisms in the nucleotide excision repair and mismatch repair pathways and colorectal cancer risk. Pubmed 2.820E-16 9.525E-14 7.416E-13 3.810E-13 4 5
5 16889989 alphaII-Spectrin interacts with five groups of functionally important proteins in the nucleus. Pubmed 4.110E-16 1.110E-13 8.646E-13 5.552E-13 5 34
6 19116388 A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. Pubmed 6.438E-16 1.270E-13 9.888E-13 8.698E-13 5 37
7 15849729 Polymorphisms in the DNA nucleotide excision repair genes and lung cancer risk in Xuan Wei, China. Pubmed 8.460E-16 1.270E-13 9.888E-13 1.143E-12 4 6
8 19434073 Common variations in ERCC2 are associated with response to cisplatin chemotherapy and clinical outcome in osteosarcoma patients. Pubmed 8.460E-16 1.270E-13 9.888E-13 1.143E-12 4 6
9 16284373 Interindividual variation in nucleotide excision repair genes and risk of endometrial cancer. Pubmed 8.460E-16 1.270E-13 9.888E-13 1.143E-12 4 6
10 16537713 Genetic variation in the nucleotide excision repair pathway and bladder cancer risk. Pubmed 1.974E-15 2.424E-13 1.888E-12 2.667E-12 4 7
11 19878615 Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Pubmed 1.974E-15 2.424E-13 1.888E-12 2.667E-12 4 7
12 19270000 Genetic susceptibility to esophageal cancer: the role of the nucleotide excision repair pathway. Pubmed 3.948E-15 4.445E-13 3.461E-12 5.334E-12 4 8
13 19536092 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. Pubmed 5.138E-15 5.340E-13 4.158E-12 6.942E-12 5 55
14 20301571 Xeroderma Pigmentosum Pubmed 7.106E-15 6.858E-13 5.339E-12 9.601E-12 4 9
15 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 1.540E-14 1.387E-12 1.080E-11 2.080E-11 5 68
16 17685459 Polymorphism in nucleotide excision repair gene XPC correlates with bleomycin-induced chromosomal aberrations. Pubmed 1.861E-14 1.571E-12 1.224E-11 2.514E-11 4 11
17 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 2.218E-14 1.763E-12 1.373E-11 2.997E-11 5 73
18 18990748 International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways. Pubmed 2.792E-14 2.095E-12 1.631E-11 3.771E-11 4 12
19 19237606 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Pubmed 4.560E-14 3.242E-12 2.524E-11 6.160E-11 5 84
20 18854777 Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy. Pubmed 7.697E-14 4.952E-12 3.856E-11 1.040E-10 4 15
21 16916636 Cockayne syndrome A and B proteins differentially regulate recruitment of chromatin remodeling and repair factors to stalled RNA polymerase II in vivo. Pubmed 7.697E-14 4.952E-12 3.856E-11 1.040E-10 4 15
22 17078101 Influence of polymorphisms in xenobiotic-metabolizing genes and DNA-repair genes on diepoxybutane-induced SCE frequency. Pubmed 1.342E-13 8.241E-12 6.417E-11 1.813E-10 4 17
23 16195237 Polymorphisms of DNA repair genes and risk of non-small cell lung cancer. Pubmed 2.732E-13 1.605E-11 1.249E-10 3.691E-10 4 20
24 20731661 Comprehensive analysis of DNA repair gene polymorphisms and survival in patients with early stage non-small-cell lung cancer. Pubmed 8.429E-13 4.745E-11 3.694E-10 1.139E-9 4 26
25 15199134 The structure-specific endonuclease Ercc1-Xpf is required to resolve DNA interstrand cross-link-induced double-strand breaks. Pubmed 1.077E-12 5.197E-11 4.046E-10 1.455E-9 3 3
26 15095299 Reduced levels of XPA, ERCC1 and XPF DNA repair proteins in testis tumor cell lines. Pubmed 1.077E-12 5.197E-11 4.046E-10 1.455E-9 3 3
27 16979838 Single-nucleotide polymorphisms in base excision repair, nucleotide excision repair, and double strand break genes as markers for response to radiotherapy in patients with Stage I to II head-and-neck cancer. Pubmed 1.077E-12 5.197E-11 4.046E-10 1.455E-9 3 3
28 8197175 Formation of a ternary complex by human XPA, ERCC1, and ERCC4(XPF) excision repair proteins. Pubmed 1.077E-12 5.197E-11 4.046E-10 1.455E-9 3 3
29 18830263 Polymorphisms in DNA repair and one-carbon metabolism genes and overall survival in diffuse large B-cell lymphoma and follicular lymphoma. Pubmed 3.320E-12 1.547E-10 1.204E-9 4.486E-9 4 36
30 17299578 Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: a meta-analysis. Pubmed 4.308E-12 1.764E-10 1.373E-9 5.820E-9 3 4
31 18204222 Single nucleotide polymorphisms in nucleotide excision repair genes XPA, XPD, XPG and ERCC1 in advanced colorectal cancer patients treated with first-line oxaliplatin/fluoropyrimidine. Pubmed 4.308E-12 1.764E-10 1.373E-9 5.820E-9 3 4
32 20864414 Polymorphisms of nucleotide-excision repair genes may contribute to sperm DNA fragmentation and male infertility. Pubmed 4.308E-12 1.764E-10 1.373E-9 5.820E-9 3 4
33 17932351 Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer risk. Pubmed 4.308E-12 1.764E-10 1.373E-9 5.820E-9 3 4
34 17313739 [Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers]. Pubmed 1.077E-11 3.829E-10 2.981E-9 1.455E-8 3 5
35 16985021 Polymorphisms in nucleotide excision repair genes and DNA repair capacity phenotype in sisters discordant for breast cancer. Pubmed 1.077E-11 3.829E-10 2.981E-9 1.455E-8 3 5
36 15746040 Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer. Pubmed 1.077E-11 3.829E-10 2.981E-9 1.455E-8 3 5
37 17438655 Association between nucleotide excision repair gene polymorphisms and chromosomal damage in coke-oven workers. Pubmed 1.077E-11 3.829E-10 2.981E-9 1.455E-8 3 5
38 20957144 Interactions between exposure to environmental polycyclic aromatic hydrocarbons and DNA repair gene polymorphisms on bulky DNA adducts in human sperm. Pubmed 1.077E-11 3.829E-10 2.981E-9 1.455E-8 3 5
39 18026184 NAT2 and NER genetic variants and sporadic prostate cancer susceptibility in African Americans. Pubmed 2.154E-11 6.928E-10 5.394E-9 2.910E-8 3 6
40 24036546 ERCC1 function in nuclear excision and interstrand crosslink repair pathways is mediated exclusively by the ERCC1-202 isoform. Pubmed 2.154E-11 6.928E-10 5.394E-9 2.910E-8 3 6
41 16399771 Polymorphisms in nucleotide excision repair genes, smoking and breast cancer in African Americans and whites: a population-based case-control study. Pubmed 2.154E-11 6.928E-10 5.394E-9 2.910E-8 3 6
42 18709642 Nucleotide excision repair genes and risk of lung cancer among San Francisco Bay Area Latinos and African Americans. Pubmed 2.154E-11 6.928E-10 5.394E-9 2.910E-8 3 6
43 17575242 Nucleotide excision repair pathway genes and oral premalignant lesions. Pubmed 3.769E-11 1.083E-9 8.436E-9 5.092E-8 3 7
44 19124519 DNA repair gene variants associated with benign breast disease in high cancer risk women. Pubmed 3.769E-11 1.083E-9 8.436E-9 5.092E-8 3 7
45 20429839 Polymorphisms in DNA damage response genes and head and neck cancer risk. Pubmed 3.769E-11 1.083E-9 8.436E-9 5.092E-8 3 7
46 10447254 A summary of mutations in the UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, and trichothiodystrophy. Pubmed 3.769E-11 1.083E-9 8.436E-9 5.092E-8 3 7
47 16492920 Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. Pubmed 3.769E-11 1.083E-9 8.436E-9 5.092E-8 3 7
48 16393248 Gene-environment interaction involved in oral carcinogenesis: molecular epidemiological study for metabolic and DNA repair gene polymorphisms. Pubmed 6.030E-11 1.697E-9 1.322E-8 8.147E-8 3 8
49 20453000 A Large-scale genetic association study of esophageal adenocarcinoma risk. Pubmed 6.372E-11 1.757E-9 1.368E-8 8.609E-8 5 351
50 20644561 A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer. Pubmed 6.845E-11 1.850E-9 1.440E-8 9.248E-8 4 75
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 203 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SPTA1 SPTA1 interactions 4.469E-13 9.071E-11 5.345E-10 9.071E-11 5 62
2 int:GTF2H1 GTF2H1 interactions 1.037E-12 1.053E-10 6.204E-10 2.106E-10 5 73
3 int:XPA XPA interactions 4.389E-11 2.970E-9 1.750E-8 8.911E-9 4 32
4 int:ERCC4 ERCC4 interactions 8.380E-8 4.001E-6 2.358E-5 1.701E-5 3 37
5 int:ERCC1 ERCC1 interactions 9.855E-8 4.001E-6 2.358E-5 2.001E-5 3 39
6 int:ERCC6 ERCC6 interactions 2.381E-7 8.054E-6 4.746E-5 4.832E-5 3 52
7 int:POLR2A POLR2A interactions 6.058E-7 1.757E-5 1.035E-4 1.230E-4 4 333
8 int:UBC UBC interactions 1.699E-6 4.312E-5 2.541E-4 3.450E-4 4 431
9 int:MSH2 MSH2 interactions 6.008E-6 1.355E-4 7.986E-4 1.220E-3 3 151
10 int:SLX4IP SLX4IP interactions 1.611E-5 3.270E-4 1.927E-3 3.270E-3 2 23
11 int:SLX1A SLX1A interactions 1.910E-5 3.524E-4 2.077E-3 3.877E-3 2 25
12 int:USP45 USP45 interactions 3.358E-5 5.681E-4 3.347E-3 6.817E-3 2 33
13 int:SLX1B SLX1B interactions 6.009E-5 9.383E-4 5.529E-3 1.220E-2 2 44
14 int:SLX4 SLX4 interactions 6.573E-5 9.530E-4 5.616E-3 1.334E-2 2 46
15 int:UBL7 UBL7 interactions 7.776E-5 1.052E-3 6.201E-3 1.578E-2 2 50
16 int:XPC XPC interactions 1.710E-4 1.978E-3 1.166E-2 3.471E-2 2 74
17 int:FANCG FANCG interactions 1.756E-4 1.978E-3 1.166E-2 3.566E-2 2 75
18 int:MUS81 MUS81 interactions 1.852E-4 1.978E-3 1.166E-2 3.759E-2 2 77
19 int:TAF10 TAF10 interactions 1.852E-4 1.978E-3 1.166E-2 3.759E-2 2 77
20 int:RPA1 RPA1 interactions 2.109E-4 2.140E-3 1.261E-2 4.281E-2 3 497
21 int:ZFC3H1 ZFC3H1 interactions 2.419E-4 2.284E-3 1.346E-2 4.911E-2 2 88
22 int:UHRF1 UHRF1 interactions 2.475E-4 2.284E-3 1.346E-2
5.024E-2
 2 89
23 int:HMGB1 HMGB1 interactions 4.878E-4 4.305E-3 2.537E-2
9.902E-2
 2 125
24 int:RAD23B RAD23B interactions 5.520E-4 4.669E-3 2.751E-2
1.121E-1
 2 133
25 int:C15orf40 C15orf40 interactions 8.471E-4 6.879E-3 4.053E-2
1.720E-1
 1 3
26 int:C10orf55 C10orf55 interactions 1.129E-3 8.818E-3
5.196E-2
2.293E-1
 1 4
27 int:PAQR3 PAQR3 interactions 1.976E-3 1.485E-2
8.754E-2
4.011E-1
 1 7
28 int:NFKBID NFKBID interactions 2.540E-3 1.841E-2
1.085E-1
5.155E-1
 1 9
29 int:OTUD1 OTUD1 interactions 3.103E-3 2.100E-2
1.237E-1
6.300E-1
 1 11
30 int:TRMT2B TRMT2B interactions 3.103E-3 2.100E-2
1.237E-1
6.300E-1
 1 11
31 int:RPA4 RPA4 interactions 4.230E-3 2.770E-2
1.632E-1
8.587E-1
 1 15
32 int:GTF2H5 GTF2H5 interactions 5.355E-3 3.397E-2
2.002E-1
1.000E0
 1 19
33 int:DBI DBI interactions 5.637E-3 3.467E-2
2.043E-1
1.000E0
 1 20
34 int:ZFAND5 ZFAND5 interactions 6.199E-3 3.595E-2
2.119E-1
1.000E0
 1 22
35 int:NTHL1 NTHL1 interactions 6.199E-3 3.595E-2
2.119E-1
1.000E0
 1 22
36 int:RPA2 RPA2 interactions 6.669E-3 3.709E-2
2.186E-1
1.000E0
 2 470
37 int:MAGIX MAGIX interactions 6.761E-3 3.709E-2
2.186E-1
1.000E0
 1 24
38 int:DEAF1 DEAF1 interactions 7.603E-3 3.811E-2
2.246E-1
1.000E0
 1 27
39 int:NGLY1 NGLY1 interactions 7.603E-3 3.811E-2
2.246E-1
1.000E0
 1 27
40 int:LCP1 LCP1 interactions 7.884E-3 3.811E-2
2.246E-1
1.000E0
 1 28
41 int:ZNF518A ZNF518A interactions 7.884E-3 3.811E-2
2.246E-1
1.000E0
 1 28
42 int:DDI2 DDI2 interactions 7.884E-3 3.811E-2
2.246E-1
1.000E0
 1 28
43 int:ERCC5 ERCC5 interactions 8.165E-3 3.855E-2
2.271E-1
1.000E0
 1 29
44 int:CDKN3 CDKN3 interactions 8.726E-3 3.937E-2
2.320E-1
1.000E0
 1 31
45 int:BTBD9 BTBD9 interactions 9.006E-3 3.937E-2
2.320E-1
1.000E0
 1 32
46 int:PDE12 PDE12 interactions 9.287E-3 3.937E-2
2.320E-1
1.000E0
 1 33
47 int:VPS37B VPS37B interactions 9.287E-3 3.937E-2
2.320E-1
1.000E0
 1 33
48 int:HMGCS1 HMGCS1 interactions 9.567E-3 3.937E-2
2.320E-1
1.000E0
 1 34
49 int:ABAT ABAT interactions 9.847E-3 3.937E-2
2.320E-1
1.000E0
 1 35
50 int:DRAP1 DRAP1 interactions 9.847E-3 3.937E-2
2.320E-1
1.000E0
 1 35
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 13q33 13q33 7.211E-4 2.883E-3 6.582E-3 3.606E-3 1 5
2 16p13.12 16p13.12 1.442E-3 2.883E-3 6.582E-3 7.209E-3 1 10
3 9q22.3 9q22.3 1.730E-3 2.883E-3 6.582E-3 8.650E-3 1 12
4 9q31.2 9q31.2 2.306E-3 2.883E-3 6.582E-3 1.153E-2 1 16
5 19q13.32 19q13.32 1.134E-2 1.134E-2 2.590E-2
5.672E-2
 1 79

11: Transcription Factor Binding Site [Display Chart] 2 input genes in category / 11 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 WCTCNATGGY UNKNOWN WCTCNATGGY UNKNOWN 1.225E-2 4.773E-2
1.441E-1
1.347E-1
 1 60
2 V$PPARA 02 V$PPARA 02 2.118E-2 4.773E-2
1.441E-1
2.330E-1
 1 104
3 V$CEBP C V$CEBP C 3.349E-2 4.773E-2
1.441E-1
3.684E-1
 1 165
4 V$RREB1 01 V$RREB1 01 3.490E-2 4.773E-2
1.441E-1
3.839E-1
 1 172
5 V$NRF2 01 V$NRF2 01 3.912E-2 4.773E-2
1.441E-1
4.303E-1
 1 193
6 V$ETS Q4 V$ETS Q4 3.992E-2 4.773E-2
1.441E-1
4.392E-1
 1 197
7 V$CEBPB 02 V$CEBPB 02 4.273E-2 4.773E-2
1.441E-1
4.700E-1
 1 211
8 V$CACCCBINDINGFACTOR Q6 V$CACCCBINDINGFACTOR Q6 4.473E-2 4.773E-2
1.441E-1
4.920E-1
 1 221
9 V$AP1 Q2 V$AP1 Q2 4.633E-2 4.773E-2
1.441E-1
5.096E-1
 1 229
10 V$AP1 Q4 V$AP1 Q4 4.653E-2 4.773E-2
1.441E-1
5.118E-1
 1 230
11 V$AP1FJ Q2 V$AP1FJ Q2 4.773E-2 4.773E-2
1.441E-1
5.250E-1
 1 236
Show 6 more annotations

12: Gene Family [Display Chart] 5 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268 General transcription factors|Xeroderma pigmentosum complementation groups|DNA helicases|ERCC excision repair associated genenames.org 3.486E-10 1.116E-9 2.324E-9 1.395E-9 3 7
2 1125 Xeroderma pigmentosum complementation groups genenames.org 5.578E-10 1.116E-9 2.324E-9 2.231E-9 3 8
3 1269 Nucleotide excision repair genenames.org 4.937E-3 5.485E-3 1.143E-2 1.975E-2 1 18
4 548 Fanconi anemia complementation groups genenames.org 5.485E-3 5.485E-3 1.143E-2 2.194E-2 1 20

13: Coexpression [Display Chart] 5 input genes in category / 496 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.296E-11 4.611E-8 3.128E-7 4.611E-8 5 230
2 17313671-SuppTable1e Human Leukemia Li07 12genes DNARepair GeneSigDB 1.065E-9 2.642E-7 1.792E-6 5.284E-7 3 12
3 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.490E-7 2.463E-5 1.671E-4 7.389E-5 3 58
4 14562049-Table2 Human StemCell Young03 142genes GeneSigDB 1.564E-6 1.940E-4 1.316E-3 7.760E-4 3 126
5 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 2.646E-6 2.624E-4 1.781E-3 1.312E-3 3 150
6 17906199-SuppTable1 Human Lung Hsu07 45genes GeneSigDB 2.618E-5 1.871E-3 1.269E-2 1.299E-2 2 38
7 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.640E-5 1.871E-3 1.269E-2 1.310E-2 3 323
8 14993899-TableS1 Human Futreal04 427genes ConsensusCancerGenes GeneSigDB 3.773E-5 2.339E-3 1.587E-2 1.871E-2 3 364
9 16434974-Table3 Human StemCell Enk06 67genes GeneSigDB 7.258E-5 4.000E-3 2.714E-2 3.600E-2 2 63
10 M5451 Survival signature genes defined in adjacent liver tissue: genes correlated with good survival of hepatocellular carcinoma (HCC) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.342E-4 1.038E-2
7.040E-2
1.161E-1
 2 113
11 M8411 Genes down-regulated in urothelial cell carcinoma (UCC) tumors with LOH on 9q as compared to the tumors showing retention. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.468E-4 1.038E-2
7.040E-2
1.224E-1
 2 116
12 M12313 Genes up-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.510E-4 1.038E-2
7.040E-2
1.245E-1
 2 117
13 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.004E-4 1.146E-2
7.776E-2
1.490E-1
 2 128
14 M19867 Genes down-regulated in acute myeloid leukemia (AML) with respect to cellular localization of NPM1 [GeneID=4869]: cytoplasmic vs. nucleolar. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.192E-4 1.450E-2
9.838E-2
3.071E-1
 2 184
15 M5182 Genes down-regulated in comparison of dendritic cells exposed to L. major versus macrophages exposed to L. major. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.450E-2
9.838E-2
3.589E-1
 2 199
16 M8430 Genes down-regulated in CD8 T cells: stem cell memory versus effector memory. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 1.450E-2
9.838E-2
3.589E-1
 2 199
17 M3488 Genes down-regulated in naive CD4 [GeneID=920] T cells from adult blood versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
18 M8434 Genes down-regulated in CD8 T cells: central memory versus effector memory. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
19 M3277 Genes up-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC stimulated with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
20 M4084 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
21 M9313 Genes up-regulated in follicular B cells versus day 40 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
22 M3507 Genes up-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 240 min. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
23 M8427 Genes down-regulated in pre-B cells: STAT5 knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
24 M5842 Genes up-regulated in comparison of virus specific (gp33) exhausted CD8 T cells versus the virus specific (gp276) cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
25 M7665 Genes up-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes: non-stimulated versus tretinoin [PubChem=444795] and Pam2CSK4 (96h). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 1.450E-2
9.838E-2
3.625E-1
 2 200
26 M9473 Genes enriched in embryonic, neural and hematopoietic stem cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.751E-4 1.479E-2
1.003E-1
3.844E-1
 2 206
27 M1757 Genes up-regulated after Cre-lox knockout of APC [GeneID=324] in the small intestine that require functional MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.053E-4 1.479E-2
1.004E-1
3.994E-1
 2 210
28 17571080-SuppTable2b Human Leukemia Sun07 283genes GeneSigDB 1.058E-3 1.875E-2
1.272E-1
5.250E-1
 2 241
29 18056454-Table2 Human Breast Mori07 09genes GeneSigDB 1.728E-3 2.955E-2
2.005E-1
8.570E-1
 1 8
30 15831697-TableS2 Human Leukemia Alcalay05 369genes GeneSigDB 1.890E-3 3.124E-2
2.120E-1
9.372E-1
 2 323
31 14683528-Table2a Human Mouth Huang03 18genes GeneSigDB 2.591E-3 4.145E-2
2.812E-1
1.000E0
 1 12
32 18794137-SuppTable1b Human Breast Creighton08 623genes GeneSigDB 2.852E-3 4.421E-2
2.999E-1
1.000E0
 2 398
33 M4625 Genes whose expression peaked at 20 min after stimulation of MCF10A cells with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-3 4.542E-2
3.082E-1
1.000E0
 1 14
34 M8463 Cluster G3: genes increasingly up-regulated in NHEK cells (normal keratinocyte) after 6 h time point upon UV-B irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.238E-3 4.588E-2
3.113E-1
1.000E0
 1 15
35 15896717-Table6 Human Leukemia Bal05 15genes GeneSigDB 3.238E-3 4.588E-2
3.113E-1
1.000E0
 1 15
36 M5304 Amplification hot spot 8: colocolized fragile sites and cancer genes in the 9q11-34 region. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.884E-3 4.878E-2
3.309E-1
1.000E0
 1 18
37 M3062 The 'group 2 set' of genes associated with acquired endocrine therapy resistance in breast tumors expressing ESR1 and ERBB2 [GeneID=2099;2064]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.970E-3 4.878E-2
3.309E-1
1.000E0
 2 471
38 M14665 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.087E-3 4.878E-2
3.309E-1
1.000E0
 2 478
39 M3898 Genes down-regulated in NHEK cells (normal epidermal keratinocytes) after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.205E-3 4.878E-2
3.309E-1
1.000E0
 2 485
40 M18954 Genes up-regulated in HCT116 cells (colon cancer) after treatment with amifostine [PubChem=2141] depending on the presence of TP53 [GeneID=7157]: TP53-positive vs TP53-null cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.878E-2
3.309E-1
1.000E0
 1 20
41 M9634 Cluster 4: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.878E-2
3.309E-1
1.000E0
 1 20
42 16969345-Table2Benign Human Ovarian Biade06 22genes benign GeneSigDB 4.315E-3 4.878E-2
3.309E-1
1.000E0
 1 20
43 M1680 Genes up-regulated by TSA alone [PubChem=5562], with non-hypermethylated promoters, in RKO cells (colorectal cancer). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.530E-3 4.878E-2
3.309E-1
1.000E0
 1 21
44 15077194-table1 Human StemCell Scian04 29genes GeneSigDB 4.530E-3 4.878E-2
3.309E-1
1.000E0
 1 21
45 M2059 Nearest neighbors of HOX11 [GeneID=3195], based on the close agreement of their expression profiles with that of HOX11 in pediatric T cell acute lymphoblastic leukemia (T-ALL). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.961E-3 4.878E-2
3.309E-1
1.000E0
 1 23
46 M2837 Genes up-regulated in oncocytic follicular carcinoma (FTC) vs mitochondrial-rich papillary carcinoma (PTC) types of thyroid cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.961E-3 4.878E-2
3.309E-1
1.000E0
 1 23
47 18234966-Table3 Mouse Ovarian Wang07 25genes GeneSigDB 5.391E-3 4.878E-2
3.309E-1
1.000E0
 1 25
48 M6840 Genes changed similarly in DU-145 cells (prostate cancer) in the absence and presence of a dominant negative form of AKT1 [GeneID=207] upon exposure to HGF [GeneID=3082] for 6 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.607E-3 4.878E-2
3.309E-1
1.000E0
 1 26
49 20081812-Table4 Human Lymphoma Sagaert10 38genes GeneSigDB 5.822E-3 4.878E-2
3.309E-1
1.000E0
 1 27
50 11906190-Table1b-1 Human Colon Iizaka02 31genes GeneSigDB 5.822E-3 4.878E-2
3.309E-1
1.000E0
 1 27
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 207 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 74 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 213 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-372-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.037E-4 1.133E-2
6.731E-2
 4.338E-2 2 328
2 hsa-miR-371a-5p:Functional MTI Functional MTI miRTarbase 2.253E-4 1.133E-2
6.731E-2
 4.798E-2 2 345
3 hsa-miR-373-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.604E-4 1.133E-2
6.731E-2
5.546E-2
 2 371
4 hsa-miR-371b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.618E-4 1.133E-2
6.731E-2
5.575E-2
 2 372
5 hsa-miR-616-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.660E-4 1.133E-2
6.731E-2
5.665E-2
 2 375
6 hsa-miR-6070:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.995E-4 2.416E-2
1.436E-1
1.916E-1
 1 13
7 hsa-miR-3144-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.766E-3 2.416E-2
1.436E-1
5.891E-1
 1 40
8 hsa-miR-7978:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.766E-3 2.416E-2
1.436E-1
5.891E-1
 1 40
9 hsa-miR-7157-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.249E-3 2.416E-2
1.436E-1
6.920E-1
 1 47
10 hsa-miR-5008-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.416E-2
1.436E-1
7.067E-1
 1 48
11 hsa-miR-6737-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.318E-3 2.416E-2
1.436E-1
7.067E-1
 1 48
12 hsa-miR-152-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.416E-2
1.436E-1
7.361E-1
 1 50
13 hsa-miR-3135a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.525E-3 2.416E-2
1.436E-1
7.508E-1
 1 51
14 hsa-miR-4427:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.663E-3 2.416E-2
1.436E-1
7.802E-1
 1 53
15 hsa-miR-96-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 2.416E-2
1.436E-1
8.243E-1
 1 56
16 hsa-miR-3074-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.077E-3 2.416E-2
1.436E-1
8.684E-1
 1 59
17 TACAATC,MIR-508:MSigDB TACAATC,MIR-508:MSigDB MSigDB 4.215E-3 2.416E-2
1.436E-1
8.978E-1
 1 61
18 CCACACA,MIR-147:MSigDB CCACACA,MIR-147:MSigDB MSigDB 4.215E-3 2.416E-2
1.436E-1
8.978E-1
 1 61
19 hsa-miR-4704-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.416E-2
1.436E-1
9.712E-1
 1 66
20 hsa-miR-3606-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.416E-2
1.436E-1
1.000E0
 1 69
21 hsa-miR-1266-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.836E-3 2.416E-2
1.436E-1
1.000E0
 1 70
22 hsa-miR-7843-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.416E-2
1.436E-1
1.000E0
 1 72
23 hsa-miR-7109-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.042E-3 2.416E-2
1.436E-1
1.000E0
 1 73
24 hsa-miR-4461:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.416E-2
1.436E-1
1.000E0
 1 74
25 hsa-miR-3918:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.416E-2
1.436E-1
1.000E0
 1 75
26 hsa-miR-1182:Functional MTI Functional MTI miRTarbase 5.180E-3 2.416E-2
1.436E-1
1.000E0
 1 75
27 hsa-miR-5572:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.318E-3 2.416E-2
1.436E-1
1.000E0
 1 77
28 hsa-miR-4260:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.318E-3 2.416E-2
1.436E-1
1.000E0
 1 77
29 TTGGGAG,MIR-150:MSigDB TTGGGAG,MIR-150:MSigDB MSigDB 5.525E-3 2.416E-2
1.436E-1
1.000E0
 1 80
30 hsa-miR-4499:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.663E-3 2.416E-2
1.436E-1
1.000E0
 1 82
31 hsa-miR-6889-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.732E-3 2.416E-2
1.436E-1
1.000E0
 1 83
32 TCTGATA,MIR-361:MSigDB TCTGATA,MIR-361:MSigDB MSigDB 6.007E-3 2.416E-2
1.436E-1
1.000E0
 1 87
33 hsa-miR-2115-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.076E-3 2.416E-2
1.436E-1
1.000E0
 1 88
34 hsa-miR-6509-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.214E-3 2.416E-2
1.436E-1
1.000E0
 1 90
35 hsa-miR-28-3p:TargetScan hsa-miR-28-3p TargetScan 6.214E-3 2.416E-2
1.436E-1
1.000E0
 1 90
36 hsa-miR-1271-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.283E-3 2.416E-2
1.436E-1
1.000E0
 1 91
37 hsa-miR-2052:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.283E-3 2.416E-2
1.436E-1
1.000E0
 1 91
38 hsa-miR-550a-3-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.283E-3 2.416E-2
1.436E-1
1.000E0
 1 91
39 hsa-miR-4263:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.489E-3 2.416E-2
1.436E-1
1.000E0
 1 94
40 hsa-miR-4436b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.489E-3 2.416E-2
1.436E-1
1.000E0
 1 94
41 hsa-miR-550a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.558E-3 2.416E-2
1.436E-1
1.000E0
 1 95
42 hsa-miR-4432:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.765E-3 2.416E-2
1.436E-1
1.000E0
 1 98
43 hsa-miR-455-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.833E-3 2.416E-2
1.436E-1
1.000E0
 1 99
44 hsa-miR-3611:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.833E-3 2.416E-2
1.436E-1
1.000E0
 1 99
45 hsa-miR-450a-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.902E-3 2.416E-2
1.436E-1
1.000E0
 1 100
46 hsa-let-7c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.971E-3 2.416E-2
1.436E-1
1.000E0
 1 101
47 hsa-miR-6848-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.971E-3 2.416E-2
1.436E-1
1.000E0
 1 101
48 hsa-miR-6846-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.971E-3 2.416E-2
1.436E-1
1.000E0
 1 101
49 hsa-miR-595:Functional MTI Functional MTI miRTarbase 6.971E-3 2.416E-2
1.436E-1
1.000E0
 1 101
50 hsa-miR-5008-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.040E-3 2.416E-2
1.436E-1
1.000E0
 1 102
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 1647 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000006199 psoralen Stitch 5.962E-13 9.819E-10 7.839E-9 9.819E-10 5 84
2 CID000010266 glucamine Stitch 2.135E-12 1.448E-9 1.156E-8 3.517E-9 4 20
3 CID000085645 iodine heptafluoride Stitch 2.638E-12 1.448E-9 1.156E-8 4.344E-9 4 21
4 CID000024401 permanganate Stitch 7.186E-11 2.959E-8 2.362E-7 1.184E-7 4 46
5 CID000001135 thymine Stitch 4.834E-10 1.421E-7 1.135E-6 7.962E-7 5 315
6 CID006437867 D dB Stitch 5.953E-10 1.421E-7 1.135E-6 9.804E-7 4 77
7 CID000043188 IF-7 Stitch 6.040E-10 1.421E-7 1.135E-6 9.948E-7 3 10
8 CID000003199 NSC648766 Stitch 1.284E-9 2.643E-7 2.110E-6 2.114E-6 4 93
9 CID000121904 6-deoxyerythronolide B Stitch 1.523E-9 2.787E-7 2.225E-6 2.508E-6 4 97
10 CID000011254 diepoxybutane Stitch 2.829E-9 4.659E-7 3.720E-6 4.659E-6 4 113
11 CID000005955 4NQO Stitch 3.145E-9 4.709E-7 3.760E-6 5.180E-6 4 116
12 CID000119184 CNDAC Stitch 5.734E-9 7.870E-7 6.284E-6 9.444E-6 3 20
13 CID005289542 UV-C Stitch 1.243E-8 1.538E-6 1.228E-5 2.047E-5 4 163
14 CID000013764 AC1L22FD Stitch 1.307E-8 1.538E-6 1.228E-5 2.153E-5 3 26
15 CID000101109 illudin S Stitch 1.647E-8 1.808E-6 1.444E-5 2.713E-5 3 28
16 CID000150345 AC1L445C Stitch 1.837E-8 1.891E-6 1.510E-5 3.025E-5 3 29
17 CID000023939 platinum Stitch 1.981E-8 1.920E-6 1.533E-5 3.263E-5 4 183
18 CID000126592 NSC668281 Stitch 3.588E-8 3.283E-6 2.621E-5 5.909E-5 3 36
19 CID000022469 N-acetoxy-2-acetylaminofluorene Stitch 3.904E-8 3.384E-6 2.702E-5 6.430E-5 3 37
20 CID000005746 mitomycin C Stitch 5.995E-8 4.937E-6 3.942E-5 9.874E-5 4 241
21 CID000535165 formamidopyrimidine Stitch 7.126E-8 5.589E-6 4.462E-5 1.174E-4 3 45
22 CID005359596 arsenic Stitch 1.004E-7 7.486E-6 5.977E-5 1.653E-4 4 274
23 CID000148189 irofulven Stitch 1.045E-7 7.486E-6 5.977E-5 1.722E-4 3 51
24 CID000002353 berberine Stitch 1.095E-7 7.512E-6 5.998E-5 1.803E-4 4 280
25 CID000065275 O6-methylguanine Stitch 2.513E-7 1.592E-5 1.271E-4 4.139E-4 3 68
26 CID000085040 CPDS Stitch 2.513E-7 1.592E-5 1.271E-4 4.139E-4 3 68
27 CID000038347 4-HC Stitch 2.990E-7 1.824E-5 1.456E-4 4.924E-4 3 72
28 ctd:C547185 riccardin D CTD 3.523E-7 2.072E-5 1.655E-4 5.803E-4 3 76
29 ctd:D058955 Metalloids CTD 3.833E-7 2.177E-5 1.738E-4 6.312E-4 2 5
30 ctd:C057270 cisplatin-DNA adduct CTD 5.749E-7 3.054E-5 2.439E-4 9.468E-4 2 6
31 CID003048164 D 283 Stitch 5.749E-7 3.054E-5 2.439E-4 9.468E-4 2 6
32 CID000025000 cobalt nitrate Stitch 8.047E-7 4.142E-5 3.307E-4 1.325E-3 2 7
33 ctd:C108830 Y 27632 CTD 8.338E-7 4.161E-5 3.323E-4 1.373E-3 3 101
34 CID000004033 nitrogen mustard Stitch 1.021E-6 4.946E-5 3.949E-4 1.682E-3 3 108
35 CID000013369 2-chloroethylamine Stitch 1.379E-6 6.140E-5 4.902E-4 2.272E-3 2 9
36 CID000393111 SJG-136 Stitch 1.379E-6 6.140E-5 4.902E-4 2.272E-3 2 9
37 ctd:D008670 Metals CTD 1.379E-6 6.140E-5 4.902E-4 2.272E-3 2 9
38 CID000119315 8-oxyguanine Stitch 1.787E-6 7.721E-5 6.165E-4 2.943E-3 3 130
39 CID000016590 DADS Stitch 1.828E-6 7.721E-5 6.165E-4 3.011E-3 3 131
40 CID000006377 propylene imine Stitch 2.107E-6 8.463E-5 6.757E-4 3.470E-3 2 11
41 CID009860529 NU7026 Stitch 2.107E-6 8.463E-5 6.757E-4 3.470E-3 2 11
42 CID000064548 AC1L21FQ Stitch 2.987E-6 1.171E-4 9.353E-4 4.920E-3 2 13
43 CID000004609 oxaliplatin Stitch 3.466E-6 1.328E-4 1.060E-3 5.708E-3 3 162
44 CID000005192 sebacate Stitch 4.838E-6 1.811E-4 1.446E-3 7.967E-3 3 181
45 CID000008569 uf-2 Stitch 5.207E-6 1.906E-4 1.522E-3 8.576E-3 2 17
46 ctd:D008148 Lovastatin CTD 7.667E-6 2.702E-4 2.157E-3 1.263E-2 3 211
47 CID000177358 ZD0473 Stitch 8.037E-6 2.702E-4 2.157E-3 1.324E-2 2 21
48 CID000070746 8-azaadenine Stitch 8.037E-6 2.702E-4 2.157E-3 1.324E-2 2 21
49 CID000410956 AC1L908O Stitch 8.037E-6 2.702E-4 2.157E-3 1.324E-2 2 21
50 ctd:C521013 veliparib CTD 8.840E-6 2.855E-4 2.279E-3 1.456E-2 2 22
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 357 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0007107 Malignant neoplasm of larynx DisGeNET BeFree 3.324E-11 1.187E-8 7.661E-8 1.187E-8 5 132
2 C0595989 Carcinoma of larynx DisGeNET Curated 1.234E-10 2.203E-8 1.422E-7 4.406E-8 5 171
3 C1968564 Defective DNA repair after ultraviolet radiation damage DisGeNET Curated 4.934E-10 5.285E-8 3.412E-7 1.761E-7 3 7
4 C0349506 Photosensitivity of skin DisGeNET Curated 5.922E-10 5.285E-8 3.412E-7 2.114E-7 4 55
5 C0009207 Cockayne Syndrome DisGeNET Curated 1.686E-9 1.006E-7 6.497E-7 6.018E-7 4 71
6 C0268141 Xeroderma pigmentosum, group G DisGeNET Curated 1.691E-9 1.006E-7 6.497E-7 6.037E-7 3 10
7 C0239105 Conjunctival telangiectasis DisGeNET Curated 5.128E-9 2.615E-7 1.688E-6 1.831E-6 3 14
8 C0151611 Electroencephalogram abnormal DisGeNET Curated 7.659E-9 3.413E-7 2.204E-6 2.734E-6 4 103
9 C0043346 Xeroderma Pigmentosum DisGeNET Curated 8.604E-9 3.413E-7 2.204E-6 3.072E-6 4 106
10 C0392777 Poikiloderma DisGeNET Curated 1.364E-8 4.871E-7 3.145E-6 4.871E-6 3 19
11 C0020619 Hypogonadism DisGeNET Curated 2.651E-8 8.603E-7 5.554E-6 9.463E-6 4 140
12 C0016689 Freckles DisGeNET Curated 7.673E-8 2.283E-6 1.474E-5 2.739E-5 3 33
13 C1846149 Progressive mental retardation DisGeNET Curated 1.092E-7 3.000E-6 1.937E-5 3.899E-5 3 37
14 C0268135 Xeroderma pigmentosum, group A DisGeNET Curated 1.389E-7 3.305E-6 2.134E-5 4.957E-5 3 40
15 C4022018 Telangiectasia of the skin DisGeNET Curated 1.389E-7 3.305E-6 2.134E-5 4.957E-5 3 40
16 C1842774 Hyperpigmented macules DisGeNET Curated 1.734E-7 3.869E-6 2.498E-5 6.190E-5 3 43
17 C1510497 Lens Opacities DisGeNET Curated 2.024E-7 4.251E-6 2.745E-5 7.227E-5 4 232
18 C0423757 Thin skin DisGeNET Curated 2.277E-7 4.517E-6 2.916E-5 8.130E-5 3 47
19 C0021364 Male infertility DisGeNET Curated 2.438E-7 4.581E-6 2.958E-5 8.704E-5 4 243
20 C0751039 Cockayne Syndrome, Type I DisGeNET Curated 2.752E-7 4.796E-6 3.096E-5 9.825E-5 3 50
21 C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 2.821E-7 4.796E-6 3.096E-5 1.007E-4 4 252
22 C0007117 Basal cell carcinoma DisGeNET Curated 3.102E-7 5.034E-6 3.250E-5 1.108E-4 3 52
23 C1859312 CAMFAK syndrome DisGeNET Curated 4.569E-7 6.524E-6 4.212E-5 1.631E-4 2 4
24 C2931277 Pena Shokeir syndrome Type 2 DisGeNET Curated 4.569E-7 6.524E-6 4.212E-5 1.631E-4 2 4
25 C1968565 Numerous pigmented freckles DisGeNET Curated 4.569E-7 6.524E-6 4.212E-5 1.631E-4 2 4
26 C1836735 hypopigmented skin patch DisGeNET Curated 4.800E-7 6.591E-6 4.256E-5 1.714E-4 3 60
27 C0262444 Dental abnormalities DisGeNET Curated 5.048E-7 6.675E-6 4.309E-5 1.802E-4 3 61
28 C0022568 Keratitis DisGeNET Curated 5.842E-7 7.449E-6 4.809E-5 2.086E-4 3 64
29 C0040427 Tooth Abnormalities DisGeNET Curated 8.714E-7 1.037E-5 6.695E-5 3.111E-4 3 73
30 C0039590 Testicular Neoplasms DisGeNET Curated 8.714E-7 1.037E-5 6.695E-5 3.111E-4 3 73
31 C0259817 Xerosis DisGeNET Curated 1.107E-6 1.235E-5 7.976E-5 3.953E-4 3 79
32 C4280568 Hardened artery wall DisGeNET Curated 1.142E-6 1.235E-5 7.976E-5 4.077E-4 2 6
33 C0268140 Xeroderma pigmentosum, group F DisGeNET Curated 1.142E-6 1.235E-5 7.976E-5 4.077E-4 2 6
34 C0018784 Sensorineural Hearing Loss (disorder) DisGeNET Curated 1.177E-6 1.236E-5 7.979E-5 4.202E-4 4 360
35 C0424688 Small head DisGeNET Curated 1.386E-6 1.413E-5 9.125E-5 4.947E-4 4 375
36 C0016382 Flushing DisGeNET Curated 1.432E-6 1.420E-5 9.169E-5 5.113E-4 3 86
37 C0151908 Dry skin DisGeNET Curated 1.483E-6 1.431E-5 9.239E-5 5.295E-4 3 87
38 C0086543 Cataract DisGeNET Curated 1.705E-6 1.602E-5 1.034E-4 6.088E-4 4 395
39 C0041834 Erythema DisGeNET Curated 1.935E-6 1.772E-5 1.144E-4 6.909E-4 3 95
40 C0220722 Cerebrooculofacioskeletal Syndrome 1 DisGeNET Curated 2.131E-6 1.822E-5 1.177E-4 7.608E-4 2 8
41 C1857121 Neurodevelopmental regression DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
42 C1855019 Psychomotor regression DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
43 C1836550 Loss of developmental milestones DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
44 C1859678 Mental deterioration in childhood DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
45 C1850493 Psychomotor regression, progressive DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
46 C1855009 Psychomotor regression in infants DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
47 C1855996 Psychomotor regression beginning in infancy DisGeNET Curated 2.399E-6 1.822E-5 1.177E-4 8.565E-4 3 102
48 C0870082 Hyperkeratosis DisGeNET Curated 2.619E-6 1.948E-5 1.257E-4 9.349E-4 3 105
49 C0003862 Arthralgia DisGeNET Curated 2.695E-6 1.963E-5 1.268E-4 9.620E-4 3 106
50 C1836830 Developmental regression DisGeNET Curated 2.932E-6 2.093E-5 1.351E-4 1.047E-3 3 109
Show 45 more annotations