Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc9_51, positive side

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1: GO: Molecular Function [Display Chart] 51 input genes in category / 259 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019200 carbohydrate kinase activity 6.788E-11 1.758E-8 1.079E-7 1.758E-8 6 26
2 GO:0008443 phosphofructokinase activity 2.449E-10 3.172E-8 1.946E-7 6.344E-8 5 14
3 GO:0005179 hormone activity 1.517E-9 1.310E-7 8.035E-7 3.929E-7 8 124
4 GO:0003872 6-phosphofructokinase activity 1.923E-8 1.245E-6 7.641E-6 4.981E-6 3 3
5 GO:0070095 fructose-6-phosphate binding 1.916E-7 8.269E-6 5.074E-5 4.962E-5 3 5
6 GO:0070061 fructose binding 1.916E-7 8.269E-6 5.074E-5 4.962E-5 3 5
7 GO:0050308 sugar-phosphatase activity 2.277E-6 8.314E-5 5.102E-4 5.897E-4 3 10
8 GO:0048029 monosaccharide binding 2.568E-6 8.314E-5 5.102E-4 6.651E-4 5 80
9 GO:0019203 carbohydrate phosphatase activity 3.124E-6 8.992E-5 5.517E-4 8.092E-4 3 11
10 GO:0017077 oxidative phosphorylation uncoupler activity 7.323E-6 1.897E-4 1.164E-3 1.897E-3 2 2
11 GO:0004332 fructose-bisphosphate aldolase activity 2.193E-5 4.586E-4 2.814E-3 5.680E-3 2 3
12 GO:0004967 glucagon receptor activity 2.193E-5 4.586E-4 2.814E-3 5.680E-3 2 3
13 GO:0033613 activating transcription factor binding 2.302E-5 4.586E-4 2.814E-3 5.961E-3 4 61
14 GO:0003873 6-phosphofructo-2-kinase activity 4.378E-5 8.100E-4 4.970E-3 1.134E-2 2 4
15 GO:0031406 carboxylic acid binding 4.718E-5 8.147E-4 4.999E-3 1.222E-2 6 240
16 GO:0043177 organic acid binding 5.056E-5 8.182E-4 5.021E-3 1.309E-2 6 243
17 GO:0030552 cAMP binding 5.371E-5 8.182E-4 5.021E-3 1.391E-2 3 27
18 GO:0004331 fructose-2,6-bisphosphate 2-phosphatase activity 7.285E-5 9.930E-4 6.093E-3 1.887E-2 2 5
19 GO:0004075 biotin carboxylase activity 7.285E-5 9.930E-4 6.093E-3 1.887E-2 2 5
20 GO:0009374 biotin binding 1.091E-4 1.413E-3 8.668E-3 2.825E-2 2 6
21 GO:0030246 carbohydrate binding 1.314E-4 1.620E-3 9.942E-3 3.403E-2 6 289
22 GO:0016885 ligase activity, forming carbon-carbon bonds 1.524E-4 1.795E-3 1.101E-2 3.948E-2 2 7
23 GO:0033218 amide binding 1.890E-4 2.056E-3 1.262E-2 4.894E-2 6 309
24 GO:0030551 cyclic nucleotide binding 1.905E-4 2.056E-3 1.262E-2 4.934E-2 3 41
25 GO:0016832 aldehyde-lyase activity 2.604E-4 2.698E-3 1.655E-2
6.745E-2
 2 9
26 GO:0016830 carbon-carbon lyase activity 3.651E-4 3.637E-3 2.232E-2
9.456E-2
 3 51
27 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 4.096E-4 3.929E-3 2.411E-2
1.061E-1
 6 357
28 GO:0005536 glucose binding 5.603E-4 5.016E-3 3.078E-2
1.451E-1
 2 13
29 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 5.617E-4 5.016E-3 3.078E-2
1.455E-1
 6 379
30 GO:0000987 proximal promoter sequence-specific DNA binding 7.256E-4 6.264E-3 3.844E-2
1.879E-1
 6 398
31 GO:0033293 monocarboxylic acid binding 1.314E-3 1.098E-2
6.735E-2
3.403E-1
 3 79
32 GO:0003713 transcription coactivator activity 1.540E-3 1.246E-2
7.646E-2
3.988E-1
 5 310
33 GO:0031210 phosphatidylcholine binding 1.786E-3 1.402E-2
8.601E-2
4.626E-1
 2 23
34 GO:0033878 hormone-sensitive lipase activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
35 GO:0004133 glycogen debranching enzyme activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
36 GO:0004736 pyruvate carboxylase activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
37 GO:0004135 amylo-alpha-1,6-glucosidase activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
38 GO:0038021 leptin receptor activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
39 GO:0031768 ghrelin receptor binding 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
40 GO:0061609 fructose-1-phosphate aldolase activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
41 GO:0031769 glucagon receptor binding 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
42 GO:0004134 4-alpha-glucanotransferase activity 2.733E-3 1.685E-2
1.034E-1
7.078E-1
 1 1
43 GO:0050699 WW domain binding 3.663E-3 2.206E-2
1.354E-1
9.486E-1
 2 33
44 GO:0001085 RNA polymerase II transcription factor binding 4.115E-3 2.422E-2
1.486E-1
1.000E0
 3 118
45 GO:0001102 RNA polymerase II activating transcription factor binding 4.834E-3 2.571E-2
1.577E-1
1.000E0
 2 38
46 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 5.434E-3 2.571E-2
1.577E-1
1.000E0
 4 259
47 GO:0008466 glycogenin glucosyltransferase activity 5.459E-3 2.571E-2
1.577E-1
1.000E0
 1 2
48 GO:0052740 1-acyl-2-lysophosphatidylserine acylhydrolase activity 5.459E-3 2.571E-2
1.577E-1
1.000E0
 1 2
49 GO:0003989 acetyl-CoA carboxylase activity 5.459E-3 2.571E-2
1.577E-1
1.000E0
 1 2
50 GO:0004353 glutamate dehydrogenase [NAD(P)+] activity 5.459E-3 2.571E-2
1.577E-1
1.000E0
 1 2
Show 45 more annotations

2: GO: Biological Process [Display Chart] 51 input genes in category / 2007 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006006 glucose metabolic process 8.166E-24 1.639E-20 1.341E-19 1.639E-20 19 229
2 GO:0019318 hexose metabolic process 1.586E-22 1.591E-19 1.302E-18 3.182E-19 19 267
3 GO:0046879 hormone secretion 1.193E-21 7.979E-19 6.528E-18 2.394E-18 20 357
4 GO:0046883 regulation of hormone secretion 1.679E-21 8.426E-19 6.894E-18 3.370E-18 19 302
5 GO:0009914 hormone transport 2.435E-21 9.774E-19 7.997E-18 4.887E-18 20 370
6 GO:0005996 monosaccharide metabolic process 3.322E-21 1.111E-18 9.092E-18 6.668E-18 19 313
7 GO:0030072 peptide hormone secretion 1.812E-20 5.195E-18 4.250E-17 3.636E-17 18 282
8 GO:0090276 regulation of peptide hormone secretion 2.938E-20 6.698E-18 5.480E-17 5.897E-17 17 235
9 GO:0002790 peptide secretion 3.004E-20 6.698E-18 5.480E-17 6.028E-17 18 290
10 GO:0002791 regulation of peptide secretion 4.219E-20 8.468E-18 6.929E-17 8.468E-17 17 240
11 GO:0023061 signal release 8.632E-19 1.520E-16 1.244E-15 1.732E-15 20 498
12 GO:0030073 insulin secretion 9.089E-19 1.520E-16 1.244E-15 1.824E-15 16 231
13 GO:0090087 regulation of peptide transport 1.008E-18 1.556E-16 1.273E-15 2.022E-15 17 289
14 GO:0015833 peptide transport 1.252E-18 1.794E-16 1.468E-15 2.512E-15 18 357
15 GO:0043434 response to peptide hormone 2.226E-18 2.979E-16 2.437E-15 4.468E-15 19 442
16 GO:0050796 regulation of insulin secretion 3.097E-18 3.725E-16 3.048E-15 6.215E-15 15 197
17 GO:0046887 positive regulation of hormone secretion 3.155E-18 3.725E-16 3.048E-15 6.333E-15 14 152
18 GO:0042886 amide transport 4.581E-18 5.107E-16 4.179E-15 9.193E-15 18 384
19 GO:0006091 generation of precursor metabolites and energy 6.909E-18 7.298E-16 5.971E-15 1.387E-14 18 393
20 GO:1901652 response to peptide 9.198E-18 9.230E-16 7.552E-15 1.846E-14 19 477
21 GO:0034284 response to monosaccharide 1.341E-17 1.281E-15 1.048E-14 2.690E-14 15 217
22 GO:0009743 response to carbohydrate 6.924E-17 6.317E-15 5.168E-14 1.390E-13 15 242
23 GO:0090277 positive regulation of peptide hormone secretion 1.595E-16 1.392E-14 1.139E-13 3.202E-13 12 112
24 GO:0002793 positive regulation of peptide secretion 2.465E-16 2.061E-14 1.687E-13 4.948E-13 12 116
25 GO:0032024 positive regulation of insulin secretion 2.857E-16 2.245E-14 1.837E-13 5.735E-13 11 83
26 GO:0009746 response to hexose 2.909E-16 2.245E-14 1.837E-13 5.838E-13 14 209
27 GO:0016051 carbohydrate biosynthetic process 5.977E-16 4.443E-14 3.635E-13 1.200E-12 14 220
28 GO:0006094 gluconeogenesis 1.350E-15 9.675E-14 7.916E-13 2.709E-12 11 95
29 GO:0019319 hexose biosynthetic process 2.162E-15 1.496E-13 1.224E-12 4.339E-12 11 99
30 GO:0061621 canonical glycolysis 2.676E-15 1.678E-13 1.373E-12 5.370E-12 8 26
31 GO:0006735 NADH regeneration 2.676E-15 1.678E-13 1.373E-12 5.370E-12 8 26
32 GO:0061718 glucose catabolic process to pyruvate 2.676E-15 1.678E-13 1.373E-12 5.370E-12 8 26
33 GO:0044262 cellular carbohydrate metabolic process 4.424E-15 2.690E-13 2.201E-12 8.879E-12 15 320
34 GO:0046364 monosaccharide biosynthetic process 4.702E-15 2.776E-13 2.271E-12 9.437E-12 11 106
35 GO:0042593 glucose homeostasis 6.143E-15 3.425E-13 2.802E-12 1.233E-11 14 260
36 GO:0033500 carbohydrate homeostasis 6.143E-15 3.425E-13 2.802E-12 1.233E-11 14 260
37 GO:0061620 glycolytic process through glucose-6-phosphate 7.306E-15 3.885E-13 3.179E-12 1.466E-11 8 29
38 GO:0009749 response to glucose 7.356E-15 3.885E-13 3.179E-12 1.476E-11 13 204
39 GO:0006090 pyruvate metabolic process 9.698E-15 4.929E-13 4.033E-12 1.946E-11 11 113
40 GO:0061615 glycolytic process through fructose-6-phosphate 9.942E-15 4.929E-13 4.033E-12 1.995E-11 8 30
41 GO:0016052 carbohydrate catabolic process 1.007E-14 4.929E-13 4.033E-12 2.021E-11 12 157
42 GO:0006007 glucose catabolic process 2.344E-14 1.120E-12 9.164E-12 4.704E-11 8 33
43 GO:0006165 nucleoside diphosphate phosphorylation 7.892E-14 3.684E-12 3.014E-11 1.584E-10 10 95
44 GO:0046939 nucleotide phosphorylation 1.640E-13 7.483E-12 6.122E-11 3.292E-10 10 102
45 GO:0006734 NADH metabolic process 2.398E-13 1.070E-11 8.751E-11 4.813E-10 8 43
46 GO:0006096 glycolytic process 5.104E-13 2.227E-11 1.822E-10 1.024E-9 9 76
47 GO:0050708 regulation of protein secretion 5.258E-13 2.245E-11 1.837E-10 1.055E-9 15 444
48 GO:0006757 ATP generation from ADP 5.767E-13 2.411E-11 1.973E-10 1.157E-9 9 77
49 GO:0044282 small molecule catabolic process 7.768E-13 3.182E-11 2.603E-10 1.559E-9 14 370
50 GO:0009132 nucleoside diphosphate metabolic process 1.414E-12 5.675E-11 4.643E-10 2.837E-9 10 126
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 51 input genes in category / 111 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005945 6-phosphofructokinase complex 1.805E-8 2.003E-6 1.060E-5 2.003E-6 3 3
2 GO:0005952 cAMP-dependent protein kinase complex 1.945E-4 1.080E-2
5.712E-2
 2.159E-2 2 8
3 GO:0061695 transferase complex, transferring phosphorus-containing groups 4.795E-4 1.774E-2
9.388E-2
5.323E-2
 5 244
4 GO:0034774 secretory granule lumen 1.527E-3 4.195E-2
2.220E-1
1.695E-1
 3 85
5 GO:0043033 isoamylase complex 2.676E-3 4.195E-2
2.220E-1
2.970E-1
 1 1
6 GO:0060205 cytoplasmic vesicle lumen 2.717E-3 4.195E-2
2.220E-1
3.016E-1
 3 104
7 GO:0097546 ciliary base 2.721E-3 4.195E-2
2.220E-1
3.020E-1
 2 29
8 GO:0031983 vesicle lumen 3.023E-3 4.195E-2
2.220E-1
3.356E-1
 3 108
Show 3 more annotations

4: Human Phenotype [Display Chart] 26 input genes in category / 983 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011015 Abnormality of blood glucose concentration 1.501E-8 1.233E-5 9.212E-5 1.475E-5 12 299
2 HP:0012337 Abnormal homeostasis 5.019E-8 1.233E-5 9.212E-5 4.934E-5 5 20
3 HP:0012340 Decreased resting energy expenditure 5.019E-8 1.233E-5 9.212E-5 4.934E-5 5 20
4 HP:0012338 Abnormal energy expenditure 5.019E-8 1.233E-5 9.212E-5 4.934E-5 5 20
5 HP:0000855 Insulin resistance 1.323E-6 2.602E-4 1.943E-3 1.301E-3 8 159
6 HP:0000831 Insulin-resistant diabetes mellitus 3.503E-6 5.217E-4 3.896E-3 3.443E-3 6 80
7 HP:0001943 Hypoglycemia 3.715E-6 5.217E-4 3.896E-3 3.652E-3 9 247
8 HP:0002157 Azotemia 1.034E-5 1.171E-3 8.744E-3 1.016E-2 8 209
9 HP:0004364 Abnormality of nitrogen compound homeostasis 1.190E-5 1.171E-3 8.744E-3 1.169E-2 8 213
10 HP:0003292 Decreased serum leptin 1.230E-5 1.171E-3 8.744E-3 1.209E-2 3 9
11 HP:0004324 Increased body weight 1.310E-5 1.171E-3 8.744E-3 1.288E-2 11 458
12 HP:0004361 Abnormality of circulating leptin level 1.751E-5 1.434E-3 1.071E-2 1.721E-2 3 10
13 HP:0004352 Abnormality of purine metabolism 2.607E-5 1.972E-3 1.472E-2 2.563E-2 6 113
14 HP:0000842 Hyperinsulinemia 4.226E-5 2.845E-3 2.125E-2 4.154E-2 6 123
15 HP:0040214 Abnormal insulin level 4.631E-5 2.845E-3 2.125E-2 4.552E-2 6 125
16 HP:0040215 Abnormal circulating insulin level 4.631E-5 2.845E-3 2.125E-2 4.552E-2 6 125
17 HP:0010932 Abnormality of nucleobase metabolism 5.066E-5 2.929E-3 2.188E-2 4.980E-2 6 127
18 HP:0002594 Pancreatic hypoplasia 7.991E-5 4.364E-3 3.259E-2
7.856E-2
 3 16
19 HP:0100800 Aplasia/Hypoplasia of the pancreas 1.368E-4 7.076E-3
5.284E-2
1.344E-1
 3 19
20 HP:0002149 Hyperuricemia 1.489E-4 7.318E-3
5.465E-2
1.464E-1
 5 96
21 HP:0000825 Hyperinsulinemic hypoglycemia 1.603E-4 7.504E-3
5.604E-2
1.576E-1
 3 20
22 HP:0008245 Pituitary hypothyroidism 1.863E-4 8.326E-3
6.218E-2
1.832E-1
 3 21
23 HP:0004368 Increased purine level 2.077E-4 8.805E-3
6.576E-2
2.042E-1
 5 103
24 HP:0004904 Maturity-onset diabetes of the young 2.150E-4 8.805E-3
6.576E-2
2.113E-1
 3 22
25 HP:0001001 Abnormality of subcutaneous fat tissue 2.536E-4 9.971E-3
7.446E-2
2.493E-1
 4 58
26 HP:0001513 Obesity 2.785E-4 1.053E-2
7.863E-2
2.737E-1
 9 424
27 HP:0009042 Marked muscular hypertrophy 2.905E-4 1.057E-2
7.898E-2
2.855E-1
 2 5
28 HP:0011787 Central hypothyroidism 3.176E-4 1.076E-2
8.039E-2
3.122E-1
 3 25
29 HP:0012094 Abnormal pancreas size 3.176E-4 1.076E-2
8.039E-2
3.122E-1
 3 25
30 HP:0005973 Fructose intolerance 4.342E-4 1.334E-2
9.961E-2
4.268E-1
 2 6
31 HP:0011033 Impairment of fructose metabolism 4.342E-4 1.334E-2
9.961E-2
4.268E-1
 2 6
32 HP:0009017 Loss of gluteal subcutaneous adipose tissue 4.342E-4 1.334E-2
9.961E-2
4.268E-1
 2 6
33 HP:0006476 Abnormality of the pancreatic islet cells 6.675E-4 1.978E-2
1.477E-1
6.561E-1
 3 32
34 HP:0003077 Hyperlipidemia 6.843E-4 1.978E-2
1.477E-1
6.726E-1
 6 204
35 HP:0003074 Hyperglycemia 8.299E-4 2.256E-2
1.685E-1
8.158E-1
 4 79
36 HP:0012093 Abnormality of endocrine pancreas physiology 8.711E-4 2.256E-2
1.685E-1
8.563E-1
 3 35
37 HP:0011016 Abnormality of urine glucose concentration 9.121E-4 2.256E-2
1.685E-1
8.966E-1
 4 81
38 HP:0003076 Glycosuria 9.121E-4 2.256E-2
1.685E-1
8.966E-1
 4 81
39 HP:0002155 Hypertriglyceridemia 9.181E-4 2.256E-2
1.685E-1
9.025E-1
 5 142
40 HP:0000124 Renal tubular dysfunction 9.181E-4 2.256E-2
1.685E-1
9.025E-1
 5 142
41 HP:0040063 Decreased adipose tissue 1.027E-3 2.358E-2
1.761E-1
1.000E0
 3 37
42 HP:0003758 Reduced subcutaneous adipose tissue 1.027E-3 2.358E-2
1.761E-1
1.000E0
 3 37
43 HP:0006274 Reduced pancreatic beta cells 1.032E-3 2.358E-2
1.761E-1
1.000E0
 2 9
44 HP:0009124 Abnormal adipose tissue morphology 1.095E-3 2.445E-2
1.826E-1
1.000E0
 6 223
45 HP:0001397 Hepatic steatosis 1.176E-3 2.570E-2
1.919E-1
1.000E0
 5 150
46 HP:0006279 Beta-cell dysfunction 1.285E-3 2.700E-2
2.017E-1
1.000E0
 2 10
47 HP:0002591 Polyphagia 1.291E-3 2.700E-2
2.017E-1
1.000E0
 3 40
48 HP:0003635 Loss of subcutaneous adipose tissue in limbs 1.565E-3 3.140E-2
2.345E-1
1.000E0
 2 11
49 HP:0100567 Endocrine pancreatic insufficiency 1.565E-3 3.140E-2
2.345E-1
1.000E0
 2 11
50 HP:0008187 Absence of secondary sex characteristics 1.706E-3 3.353E-2
2.504E-1
1.000E0
 3 44
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 46 input genes in category / 1829 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005438 abnormal glycogen homeostasis 8.090E-17 1.480E-13 1.197E-12 1.480E-13 15 156
2 MP:0005437 abnormal glycogen level 5.843E-16 5.343E-13 4.322E-12 1.069E-12 14 140
3 MP:0002694 abnormal pancreas secretion 2.196E-15 1.339E-12 1.083E-11 4.017E-12 15 194
4 MP:0002079 increased circulating insulin level 1.880E-14 8.078E-12 6.535E-11 3.439E-11 15 224
5 MP:0003564 abnormal insulin secretion 2.208E-14 8.078E-12 6.535E-11 4.039E-11 14 181
6 MP:0014195 abnormal endocrine pancreas secretion 2.779E-14 8.325E-12 6.734E-11 5.084E-11 14 184
7 MP:0005280 abnormal fatty acid level 3.186E-14 8.325E-12 6.734E-11 5.828E-11 16 284
8 MP:0003562 abnormal pancreatic beta cell physiology 1.432E-13 3.196E-11 2.585E-10 2.618E-10 14 207
9 MP:0001553 abnormal circulating free fatty acids level 1.747E-13 3.196E-11 2.585E-10 3.196E-10 14 210
10 MP:0010147 abnormal endocrine pancreas physiology 1.747E-13 3.196E-11 2.585E-10 3.196E-10 14 210
11 MP:0010358 abnormal free fatty acids level 3.536E-13 5.879E-11 4.756E-10 6.467E-10 14 221
12 MP:0012778 abnormal liver triglyceride level 8.070E-13 1.202E-10 9.726E-10 1.476E-9 13 186
13 MP:0005281 increased fatty acid level 8.546E-13 1.202E-10 9.726E-10 1.563E-9 12 144
14 MP:0005293 impaired glucose tolerance 1.255E-12 1.639E-10 1.326E-9 2.295E-9 16 360
15 MP:0002693 abnormal pancreas physiology 2.771E-12 3.379E-10 2.733E-9 5.069E-9 15 315
16 MP:0005559 increased circulating glucose level 4.976E-12 5.603E-10 4.533E-9 9.101E-9 16 394
17 MP:0009356 decreased liver triglyceride level 5.208E-12 5.603E-10 4.533E-9 9.526E-9 10 91
18 MP:0005440 increased glycogen level 5.827E-12 5.921E-10 4.789E-9 1.066E-8 9 63
19 MP:0005317 increased triglyceride level 1.306E-11 1.257E-9 1.017E-8 2.389E-8 14 288
20 MP:0001554 increased circulating free fatty acid level 2.029E-11 1.856E-9 1.501E-8 3.712E-8 10 104
21 MP:0005288 abnormal oxygen consumption 2.625E-11 2.287E-9 1.850E-8 4.802E-8 12 192
22 MP:0001552 increased circulating triglyceride level 3.769E-11 3.134E-9 2.535E-8 6.894E-8 12 198
23 MP:0013561 abnormal endocrine gland physiology 9.322E-11 7.413E-9 5.997E-8 1.705E-7 15 403
24 MP:0005292 improved glucose tolerance 9.996E-11 7.617E-9 6.162E-8 1.828E-7 13 272
25 MP:0002727 decreased circulating insulin level 1.516E-10 1.109E-8 8.969E-8 2.772E-7 14 346
26 MP:0003059 decreased insulin secretion 2.576E-10 1.812E-8 1.466E-7 4.712E-7 10 134
27 MP:0005331 insulin resistance 3.820E-10 2.544E-8 2.058E-7 6.987E-7 11 187
28 MP:0002628 hepatic steatosis 3.894E-10 2.544E-8 2.058E-7 7.122E-7 12 242
29 MP:0011019 abnormal adaptive thermogenesis 5.428E-10 3.424E-8 2.769E-7 9.929E-7 9 103
30 MP:0011049 impaired adaptive thermogenesis 6.908E-10 4.211E-8 3.407E-7 1.263E-6 8 71
31 MP:0005449 abnormal food intake 8.487E-10 5.007E-8 4.050E-7 1.552E-6 15 472
32 MP:0004893 decreased adiponectin level 1.167E-9 6.669E-8 5.394E-7 2.134E-6 7 47
33 MP:0011969 abnormal circulating triglyceride level 1.698E-9 9.413E-8 7.615E-7 3.106E-6 14 416
34 MP:0005666 abnormal adipose tissue physiology 2.668E-9 1.435E-7 1.161E-6 4.879E-6 9 123
35 MP:0000189 hypoglycemia 3.080E-9 1.609E-7 1.302E-6 5.632E-6 9 125
36 MP:0005334 abnormal fat pad morphology 4.878E-9 2.478E-7 2.005E-6 8.922E-6 12 302
37 MP:0005318 decreased triglyceride level 7.842E-9 3.876E-7 3.136E-6 1.434E-5 12 315
38 MP:0002970 abnormal white adipose tissue morphology 8.419E-9 4.032E-7 3.261E-6 1.540E-5 12 317
39 MP:0005450 abnormal energy expenditure 8.597E-9 4.032E-7 3.261E-6 1.572E-5 11 251
40 MP:0000010 abnormal abdominal fat pad morphology 9.339E-9 4.270E-7 3.454E-6 1.708E-5 11 253
41 MP:0005448 abnormal energy homeostasis 1.145E-8 5.004E-7 4.048E-6 2.094E-5 11 258
42 MP:0010400 increased liver glycogen level 1.149E-8 5.004E-7 4.048E-6 2.102E-5 6 37
43 MP:0005458 increased percent body fat/body weight 1.217E-8 5.176E-7 4.187E-6 2.226E-5 7 65
44 MP:0010954 abnormal cellular respiration 1.832E-8 7.615E-7 6.160E-6 3.351E-5 9 153
45 MP:0005282 decreased fatty acid level 1.939E-8 7.882E-7 6.376E-6 3.547E-5 9 154
46 MP:0002971 abnormal brown adipose tissue morphology 2.295E-8 9.127E-7 7.382E-6 4.198E-5 9 157
47 MP:0009355 increased liver triglyceride level 2.699E-8 1.050E-6 8.495E-6 4.936E-5 8 112
48 MP:0005668 decreased circulating leptin level 2.895E-8 1.103E-6 8.922E-6 5.294E-5 8 113
49 MP:0005290 decreased oxygen consumption 3.356E-8 1.223E-6 9.889E-6 6.139E-5 7 75
50 MP:0004891 abnormal adiponectin level 3.356E-8 1.223E-6 9.889E-6 6.139E-5 7 75
Show 45 more annotations

6: Domain [Display Chart] 51 input genes in category / 348 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR000023 Phosphofructokinase dom InterPro 1.900E-8 1.102E-6 7.088E-6 6.613E-6 3 3
2 IPR022953 ATP PFK InterPro 1.900E-8 1.102E-6 7.088E-6 6.613E-6 3 3
3 IPR009161 6-Pfructokinase euk InterPro 1.900E-8 1.102E-6 7.088E-6 6.613E-6 3 3
4 PS00433 PHOSPHOFRUCTOKINASE PROSITE 1.900E-8 1.102E-6 7.088E-6 6.613E-6 3 3
5 IPR015912 Phosphofructokinase CS InterPro 1.900E-8 1.102E-6 7.088E-6 6.613E-6 3 3
6 PF00365 PFK Pfam 1.900E-8 1.102E-6 7.088E-6 6.613E-6 3 3
7 IPR002030 Mit uncoupling InterPro 4.109E-6 2.043E-4 1.314E-3 1.430E-3 3 12
8 IPR029768 Aldolase I AS InterPro 2.176E-5 6.310E-4 4.058E-3 7.572E-3 2 3
9 PF00274 Glycolytic Pfam 2.176E-5 6.310E-4 4.058E-3 7.572E-3 2 3
10 PS00158 ALDOLASE CLASS I PROSITE 2.176E-5 6.310E-4 4.058E-3 7.572E-3 2 3
11 IPR000741 FBA I InterPro 2.176E-5 6.310E-4 4.058E-3 7.572E-3 2 3
12 IPR003074 1Cnucl rcpt InterPro 2.176E-5 6.310E-4 4.058E-3 7.572E-3 2 3
13 IPR003094 6Pfruct kin InterPro 4.344E-5 1.008E-3 6.481E-3 1.512E-2 2 4
14 IPR013079 6Phosfructo kin InterPro 4.344E-5 1.008E-3 6.481E-3 1.512E-2 2 4
15 PF01591 6PF2K Pfam 4.344E-5 1.008E-3 6.481E-3 1.512E-2 2 4
16 IPR002113 Aden trnslctor InterPro 5.934E-5 1.094E-3 7.032E-3 2.065E-2 3 28
17 PS50979 BC PROSITE 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
18 SM00878 Biotin carb C SMART 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
19 IPR005482 Biotin COase C InterPro 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
20 PF02785 Biotin carb C Pfam 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
21 PS00188 BIOTIN PROSITE 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
22 IPR001882 Biotin BS InterPro 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
23 IPR011764 Biotin carboxylation dom InterPro 7.227E-5 1.094E-3 7.032E-3 2.515E-2 2 5
24 IPR002067 Mit carrier InterPro 8.915E-5 1.293E-3 8.313E-3 3.102E-2 3 32
25 PS00260 GLUCAGON PROSITE 1.082E-4 1.299E-3 8.352E-3 3.766E-2 2 6
26 SM00070 GLUCA SMART 1.082E-4 1.299E-3 8.352E-3 3.766E-2 2 6
27 PF00123 Hormone 2 Pfam 1.082E-4 1.299E-3 8.352E-3 3.766E-2 2 6
28 IPR000532 Glucagon GIP secretin VIP InterPro 1.082E-4 1.299E-3 8.352E-3 3.766E-2 2 6
29 IPR011054 Rudment hybrid motif InterPro 1.082E-4 1.299E-3 8.352E-3 3.766E-2 2 6
30 IPR005481 BC-like N InterPro 1.512E-4 1.595E-3 1.026E-2
5.263E-2
 2 7
31 IPR005479 CbamoylP synth lsu-like ATP-bd InterPro 1.512E-4 1.595E-3 1.026E-2
5.263E-2
 2 7
32 PF00289 Biotin carb N Pfam 1.512E-4 1.595E-3 1.026E-2
5.263E-2
 2 7
33 PF02786 CPSase L D2 Pfam 1.512E-4 1.595E-3 1.026E-2
5.263E-2
 2 7
34 3.20.20.70 - Gene3D 2.024E-4 2.072E-3 1.332E-2
7.044E-2
 3 42
35 IPR013785 Aldolase TIM InterPro 2.326E-4 2.313E-3 1.487E-2
8.096E-2
 3 44
36 IPR001345 PG/BPGM mutase AS InterPro 2.584E-4 2.430E-3 1.563E-2
8.992E-2
 2 9
37 PF00364 Biotin lipoyl Pfam 2.584E-4 2.430E-3 1.563E-2
8.992E-2
 2 9
38 PS50968 BIOTINYL LIPOYL PROSITE 3.224E-4 2.737E-3 1.760E-2
1.122E-1
 2 10
39 PS00175 PG MUTASE PROSITE 3.224E-4 2.737E-3 1.760E-2
1.122E-1
 2 10
40 SM00855 PGAM SMART 3.224E-4 2.737E-3 1.760E-2
1.122E-1
 2 10
41 IPR000089 Biotin lipoyl InterPro 3.224E-4 2.737E-3 1.760E-2
1.122E-1
 2 10
42 IPR018108 Mitochondrial sb/sol carrier InterPro 4.044E-4 3.060E-3 1.968E-2
1.407E-1
 3 53
43 IPR023395 Mt carrier dom InterPro 4.044E-4 3.060E-3 1.968E-2
1.407E-1
 3 53
44 PS50920 SOLCAR PROSITE 4.044E-4 3.060E-3 1.968E-2
1.407E-1
 3 53
45 PF00153 Mito carr Pfam 4.044E-4 3.060E-3 1.968E-2
1.407E-1
 3 53
46 1.50.40.10 - Gene3D 4.044E-4 3.060E-3 1.968E-2
1.407E-1
 3 53
47 IPR013078 His Pase superF clade-1 InterPro 4.712E-4 3.347E-3 2.152E-2
1.640E-1
 2 12
48 PF00300 His Phos 1 Pfam 4.712E-4 3.347E-3 2.152E-2
1.640E-1
 2 12
49 IPR011053 Single hybrid motif InterPro 4.712E-4 3.347E-3 2.152E-2
1.640E-1
 2 12
50 3.40.50.20 - Gene3D 5.559E-4 3.869E-3 2.488E-2
1.935E-1
 2 13
Show 45 more annotations

7: Pathway [Display Chart] 50 input genes in category / 515 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269959 Glucose metabolism BioSystems: REACTOME 4.004E-18 2.062E-15 1.407E-14 2.062E-15 13 81
2 989139 AMPK signaling pathway BioSystems: KEGG 9.365E-16 2.411E-13 1.645E-12 4.823E-13 13 121
3 1269957 Metabolism of carbohydrates BioSystems: REACTOME 1.745E-14 2.996E-12 2.044E-11 8.987E-12 16 297
4 1269960 Glycolysis BioSystems: REACTOME 3.678E-13 4.736E-11 3.231E-10 1.894E-10 8 32
5 PW:0000640 glycolysis pathway Pathway Ontology 1.212E-12 1.249E-10 8.518E-10 6.243E-10 7 21
6 82930 Fructose and mannose metabolism BioSystems: KEGG 4.294E-11 3.686E-9 2.515E-8 2.212E-8 7 33
7 82926 Glycolysis / Gluconeogenesis BioSystems: KEGG 2.053E-10 1.510E-8 1.030E-7 1.057E-7 8 67
8 1144996 Glucagon signaling pathway BioSystems: KEGG 2.407E-10 1.550E-8 1.057E-7 1.240E-7 9 103
9 137911 FOXA2 and FOXA3 transcription factor networks BioSystems: Pathway Interaction Database 3.726E-10 2.019E-8 1.377E-7 1.919E-7 7 44
10 MAP00051 Fructose and mannose metabolism MAP00051 Fructose and mannose metabolism GenMAPP 3.920E-10 2.019E-8 1.377E-7 2.019E-7 6 24
11 413340 Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate BioSystems: KEGG 5.142E-10 2.408E-8 1.642E-7 2.648E-7 6 25
12 MAP00010 Glycolysis Gluconeogenesis MAP00010 Glycolysis Gluconeogenesis GenMAPP 1.270E-9 5.398E-8 3.683E-7 6.538E-7 7 52
13 PW:0000025 glycolysis/gluconeogenesis Pathway Ontology 1.363E-9 5.398E-8 3.683E-7 7.017E-7 6 29
14 782396 glycolysis BioSystems: BIOCYC 2.479E-9 9.118E-8 6.221E-7 1.277E-6 5 15
15 PW:0000041 fructose and mannose metabolic Pathway Ontology 3.594E-9 1.234E-7 8.419E-7 1.851E-6 5 16
16 MAP00030 Pentose phosphate pathway MAP00030 Pentose phosphate GenMAPP 5.077E-9 1.634E-7 1.115E-6 2.615E-6 5 17
17 83093 Adipocytokine signaling pathway BioSystems: KEGG 9.724E-9 2.946E-7 2.010E-6 5.008E-6 7 69
18 814926 Carbon metabolism BioSystems: KEGG 1.503E-8 4.301E-7 2.934E-6 7.742E-6 8 114
19 1270341 Regulation of gene expression in beta cells BioSystems: REACTOME 1.649E-8 4.471E-7 3.050E-6 8.495E-6 5 21
20 1268750 Incretin synthesis, secretion, and inactivation BioSystems: REACTOME 2.711E-8 6.981E-7 4.763E-6 1.396E-5 5 23
21 PW:0000042 galactose metabolic Pathway Ontology 2.857E-8 7.008E-7 4.781E-6 1.472E-5 4 9
22 MAP00052 Galactose metabolism MAP00052 Galactose metabolism GenMAPP 3.414E-8 7.992E-7 5.453E-6 1.758E-5 5 24
23 777534 Insulin secretion BioSystems: KEGG 4.238E-8 9.489E-7 6.474E-6 2.183E-5 7 85
24 83096 Maturity onset diabetes of the young BioSystems: KEGG 5.252E-8 1.127E-6 7.689E-6 2.705E-5 5 26
25 82928 Pentose phosphate pathway BioSystems: KEGG 1.124E-7 2.316E-6 1.580E-5 5.790E-5 5 30
26 82931 Galactose metabolism BioSystems: KEGG 1.336E-7 2.647E-6 1.806E-5 6.882E-5 5 31
27 1269961 Gluconeogenesis BioSystems: REACTOME 1.579E-7 3.012E-6 2.055E-5 8.132E-5 5 32
28 1270337 Regulation of beta-cell development BioSystems: REACTOME 1.855E-7 3.413E-6 2.328E-5 9.555E-5 5 33
29 1270101 Integration of energy metabolism BioSystems: REACTOME 2.695E-7 4.786E-6 3.265E-5 1.388E-4 7 111
30 835393 superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle BioSystems: BIOCYC 2.921E-7 5.014E-6 3.421E-5 1.504E-4 5 36
31 790012 Biosynthesis of amino acids BioSystems: KEGG 5.023E-7 8.345E-6 5.693E-5 2.587E-4 6 75
32 PW:0000641 gluconeogenesis pathway Pathway Ontology 5.271E-7 8.483E-6 5.788E-5 2.715E-4 4 17
33 1270130 Mitochondrial Uncoupling Proteins BioSystems: REACTOME 6.061E-7 8.918E-6 6.084E-5 3.121E-4 3 5
34 1270132 The proton buffering model BioSystems: REACTOME 6.061E-7 8.918E-6 6.084E-5 3.121E-4 3 5
35 1270131 The fatty acid cycling model BioSystems: REACTOME 6.061E-7 8.918E-6 6.084E-5 3.121E-4 3 5
36 1268751 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) BioSystems: REACTOME 1.064E-6 1.498E-5 1.022E-4 5.477E-4 4 20
37 1017634 cAMP signaling pathway BioSystems: KEGG 1.076E-6 1.498E-5 1.022E-4 5.542E-4 8 198
38 83090 Insulin signaling pathway BioSystems: KEGG 1.184E-6 1.605E-5 1.095E-4 6.100E-4 7 138
39 1268746 Peptide hormone metabolism BioSystems: REACTOME 1.584E-6 2.092E-5 1.427E-4 8.157E-4 6 91
40 1269572 Glucagon-type ligand receptors BioSystems: REACTOME 5.841E-6 7.365E-5 5.025E-4 3.008E-3 4 30
41 1059538 Central carbon metabolism in cancer BioSystems: KEGG 5.863E-6 7.365E-5 5.025E-4 3.020E-3 5 65
42 83042 PPAR signaling pathway BioSystems: KEGG 9.725E-6 1.192E-4 8.135E-4 5.008E-3 5 72
43 82974 Starch and sucrose metabolism BioSystems: KEGG 1.233E-5 1.477E-4 1.008E-3 6.352E-3 4 36
44 PW:0000364 altered leptin system Pathway Ontology 1.581E-5 1.809E-4 1.234E-3 8.141E-3 2 2
45 PW:0000357 energy homeostasis Pathway Ontology 1.581E-5 1.809E-4 1.234E-3 8.141E-3 2 2
46 1270102 Regulation of insulin secretion BioSystems: REACTOME 1.631E-5 1.826E-4 1.246E-3 8.400E-3 5 80
47 1268752 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) BioSystems: REACTOME 1.695E-5 1.857E-4 1.267E-3 8.727E-3 3 13
48 PW:0000045 pentose phosphate Pathway Ontology 2.151E-5 2.307E-4 1.574E-3 1.108E-2 3 14
49 1270107 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion BioSystems: REACTOME 2.302E-5 2.420E-4 1.651E-3 1.186E-2 4 42
50 1269575 G alpha (s) signalling events BioSystems: REACTOME 2.438E-5 2.511E-4 1.713E-3 1.255E-2 6 146
Show 45 more annotations

8: Pubmed [Display Chart] 51 input genes in category / 21204 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18996102 Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. Pubmed 3.367E-24 7.140E-20 7.525E-19 7.140E-20 14 117
2 19491387 Severe obesity is associated with novel single nucleotide polymorphisms of the ESR1 and PPARgamma locus in Han Chinese. Pubmed 4.438E-22 4.705E-18 4.959E-17 9.411E-18 10 32
3 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 1.130E-17 7.985E-14 8.415E-13 2.395E-13 13 250
4 12395215 Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohort. Pubmed 1.168E-16 6.191E-13 6.524E-12 2.476E-12 6 8
5 19367093 Association study between candidate genes and obesity-related phenotypes using a sample of lumberjacks. Pubmed 1.550E-16 6.573E-13 6.928E-12 3.287E-12 7 18
6 28245920 Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Pubmed 2.720E-16 9.614E-13 1.013E-11 5.768E-12 10 109
7 18398047 Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Pubmed 3.500E-16 1.060E-12 1.117E-11 7.421E-12 6 9
8 29728617 Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function. Pubmed 8.273E-16 1.853E-12 1.953E-11 1.754E-11 7 22
9 20468064 Association study of 182 candidate genes in anorexia nervosa. Pubmed 8.553E-16 1.853E-12 1.953E-11 1.814E-11 11 182
10 18828733 Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: linkage of candidate genes using two sib-pair based variance components analyses. Pubmed 8.741E-16 1.853E-12 1.953E-11 1.853E-11 6 10
11 20602615 Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pubmed 1.551E-15 2.990E-12 3.151E-11 3.289E-11 11 192
12 19578796 Association of genetic variants with chronic kidney disease in individuals with different lipid profiles. Pubmed 8.202E-15 1.449E-11 1.527E-10 1.739E-10 10 152
13 22013016 Convergence of the insulin and serotonin programs in the pancreatic β-cell. Pubmed 1.264E-14 2.062E-11 2.173E-10 2.680E-10 7 31
14 22326222 Imprinted gene dosage is critical for the transition to independent life. Pubmed 7.665E-14 1.151E-10 1.214E-9 1.625E-9 6 18
15 20734064 A large-scale candidate gene association study of age at menarche and age at natural menopause. Pubmed 8.145E-14 1.151E-10 1.214E-9 1.727E-9 11 275
16 27185876 Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function. Pubmed 1.597E-13 2.117E-10 2.231E-9 3.387E-9 6 20
17 28049690 Rewiring of embryonic glucose metabolism via suppression of PFK-1 and aldolase during mouse chorioallantoic branching. Pubmed 1.937E-13 2.416E-10 2.546E-9 4.107E-9 5 8
18 23260145 Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Pubmed 2.151E-13 2.534E-10 2.670E-9 4.561E-9 7 45
19 27215380 Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. Pubmed 4.856E-13 5.419E-10 5.711E-9 1.030E-8 8 92
20 20682687 Common variants in 40 genes assessed for diabetes incidence and response to metformin and lifestyle intervention in the diabetes prevention program. Pubmed 5.454E-13 5.783E-10 6.094E-9 1.157E-8 7 51
21 15031110 The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity. Pubmed 1.593E-12 1.609E-9 1.696E-8 3.378E-8 5 11
22 19077438 Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations. Pubmed 2.422E-12 2.061E-9 2.172E-8 5.136E-8 6 30
23 12679465 Body fat mass and macronutrient intake in relation to circulating soluble leptin receptor, free leptin index, adiponectin, and resistin concentrations in healthy humans. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
24 18280066 Change in adipocytokines and ghrelin with menopause. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
25 9133562 Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
26 23663741 Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
27 28195351 Association of ADIPOQ, leptin, LEPR, and resistin polymorphisms with obesity parameters in Hammam Sousse Sahloul Heart Study. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
28 27559858 The Relationship Between Skinfold Thickness and Leptin, Ghrelin, Adiponectin, and Resistin Levels in Infants of Diabetic Mothers. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
29 19273568 Genetic variation in adipokine genes and risk of colorectal cancer. Pubmed 2.819E-12 2.061E-9 2.172E-8 5.978E-8 4 4
30 26220403 14-3-3ζ coordinates adipogenesis of visceral fat. Pubmed 5.464E-12 3.862E-9 4.070E-8 1.159E-7 6 34
31 9584121 Mice lacking the homeodomain transcription factor Nkx2.2 have diabetes due to arrested differentiation of pancreatic beta cells. Pubmed 6.883E-12 4.708E-9 4.962E-8 1.460E-7 5 14
32 24703692 Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice. Pubmed 7.897E-12 5.233E-9 5.515E-8 1.675E-7 6 36
33 19056482 Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome. Pubmed 1.328E-11 8.294E-9 8.741E-8 2.815E-7 7 79
34 12075579 Genetic factors as predictors of weight gain in young adult Dutch men and women. Pubmed 1.408E-11 8.294E-9 8.741E-8 2.986E-7 4 5
35 18510797 No association of defined variability in leptin, leptin receptor, adiponectin, proopiomelanocortin and ghrelin gene with food preferences in the Czech population. Pubmed 1.408E-11 8.294E-9 8.741E-8 2.986E-7 4 5
36 22037645 Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Pubmed 1.408E-11 8.294E-9 8.741E-8 2.986E-7 4 5
37 18723011 A dosage-dependent requirement for Sox9 in pancreatic endocrine cell formation. Pubmed 1.499E-11 8.590E-9 9.053E-8 3.178E-7 5 16
38 29688375 CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Pubmed 1.572E-11 8.772E-9 9.245E-8 3.333E-7 8 141
39 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 2.091E-11 1.071E-8 1.129E-7 4.434E-7 9 229
40 23193182 Islet α-, β-, and δ-cell development is controlled by the Ldb1 coregulator, acting primarily with the islet-1 transcription factor. Pubmed 2.114E-11 1.071E-8 1.129E-7 4.483E-7 6 42
41 18719582 PRDM16 controls a brown fat/skeletal muscle switch. Pubmed 2.121E-11 1.071E-8 1.129E-7 4.498E-7 5 17
42 15944193 NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas. Pubmed 2.121E-11 1.071E-8 1.129E-7 4.498E-7 5 17
43 20857084 Genetic evidence of the programming of beta cell mass and function by glucocorticoids in mice. Pubmed 2.934E-11 1.447E-8 1.525E-7 6.222E-7 5 18
44 20416077 Identification of type 2 diabetes-associated combination of SNPs using support vector machine. Pubmed 3.662E-11 1.726E-8 1.819E-7 7.765E-7 7 91
45 27689697 Mtu1-Mediated Thiouridine Formation of Mitochondrial tRNAs Is Required for Mitochondrial Translation and Is Involved in Reversible Infantile Liver Injury. Pubmed 3.662E-11 1.726E-8 1.819E-7 7.765E-7 7 91
46 16150499 Adiponectin is expressed in the brown adipose tissue and surrounding immature tissues in mouse embryos. Pubmed 4.220E-11 1.864E-8 1.965E-7 8.949E-7 4 6
47 11466580 Association between polymorphisms in candidate genes and morbid obesity. Pubmed 4.220E-11 1.864E-8 1.965E-7 8.949E-7 4 6
48 11089532 Up-regulation of peroxisome proliferator-activated receptors (PPAR-alpha) and PPAR-gamma messenger ribonucleic acid expression in the liver in murine obesity: troglitazone induces expression of PPAR-gamma-responsive adipose tissue-specific genes in the liver of obese diabetic mice. Pubmed 4.220E-11 1.864E-8 1.965E-7 8.949E-7 4 6
49 28324027 Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues. Pubmed 1.447E-10 6.261E-8 6.598E-7 3.068E-6 5 24
50 20855565 Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. Pubmed 1.785E-10 7.512E-8 7.917E-7 3.785E-6 6 59
Show 45 more annotations

9: Interaction [Display Chart] 50 input genes in category / 1376 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PRKAA2 PRKAA2 interactions 9.121E-9 1.255E-5 9.795E-5 1.255E-5 7 96
2 int:GCK GCK interactions 5.519E-8 3.797E-5 2.963E-4 7.594E-5 4 14
3 int:SLC2A2 SLC2A2 interactions 1.175E-6 5.391E-4 4.208E-3 1.617E-3 3 8
4 int:GCG GCG interactions 1.760E-6 5.753E-4 4.490E-3 2.421E-3 3 9
5 int:LEP LEP interactions 2.509E-6 5.753E-4 4.490E-3 3.452E-3 3 10
6 int:TNP1 TNP1 interactions 2.509E-6 5.753E-4 4.490E-3 3.452E-3 3 10
7 int:MEP1B MEP1B interactions 7.550E-6 1.484E-3 1.158E-2 1.039E-2 3 14
8 int:PRKACA PRKACA interactions 1.374E-5 2.143E-3 1.673E-2 1.891E-2 7 283
9 int:POU1F1 POU1F1 interactions 1.402E-5 2.143E-3 1.673E-2 1.929E-2 3 17
10 int:PDX1 PDX1 interactions 1.990E-5 2.685E-3 2.095E-2 2.738E-2 3 19
11 int:GHSR GHSR interactions 2.341E-5 2.685E-3 2.095E-2 3.221E-2 2 3
12 int:GLP2R GLP2R interactions 2.341E-5 2.685E-3 2.095E-2 3.221E-2 2 3
13 int:PFKFB3 PFKFB3 interactions 4.115E-5 4.356E-3 3.399E-2
5.662E-2
 3 24
14 int:PPARGC1A PPARGC1A interactions 6.219E-5 6.112E-3 4.770E-2
8.557E-2
 4 76
15 int:FOXO1 FOXO1 interactions 7.237E-5 6.326E-3 4.937E-2
9.959E-2
 4 79
16 int:FOXA2 FOXA2 interactions 7.356E-5 6.326E-3 4.937E-2
1.012E-1
 3 29
17 int:GOT2 GOT2 interactions 8.157E-5 6.602E-3
5.153E-2
1.122E-1
 3 30
18 int:PLIN1 PLIN1 interactions 1.164E-4 8.638E-3
6.741E-2
1.602E-1
 2 6
19 int:PFKFB2 PFKFB2 interactions 1.193E-4 8.638E-3
6.741E-2
1.641E-1
 3 34
20 int:AKAP13 AKAP13 interactions 1.417E-4 9.752E-3
7.611E-2
1.950E-1
 3 36
21 int:IAPP IAPP interactions 2.165E-4 1.354E-2
1.057E-1
2.980E-1
 2 8
22 int:PALM2-AKAP2 PALM2-AKAP2 interactions 2.165E-4 1.354E-2
1.057E-1
2.980E-1
 2 8
23 int:MCFD2 MCFD2 interactions 2.588E-4 1.471E-2
1.148E-1
3.561E-1
 3 44
24 int:PSMG1 PSMG1 interactions 2.767E-4 1.471E-2
1.148E-1
3.808E-1
 3 45
25 int:LHX3 LHX3 interactions 2.779E-4 1.471E-2
1.148E-1
3.824E-1
 2 9
26 int:FABP1 FABP1 interactions 2.779E-4 1.471E-2
1.148E-1
3.824E-1
 2 9
27 int:LMX1A LMX1A interactions 3.468E-4 1.767E-2
1.379E-1
4.771E-1
 2 10
28 int:GHRL GHRL interactions 5.067E-4 2.490E-2
1.944E-1
6.973E-1
 2 12
29 int:DYNLL1 DYNLL1 interactions 5.768E-4 2.737E-2
2.136E-1
7.937E-1
 5 241
30 int:AKAP14 AKAP14 interactions 5.978E-4 2.742E-2
2.140E-1
8.226E-1
 2 13
31 int:LIPE LIPE interactions 6.962E-4 2.903E-2
2.266E-1
9.579E-1
 2 14
32 int:ITPKB ITPKB interactions 6.962E-4 2.903E-2
2.266E-1
9.579E-1
 2 14
33 int:GJB1 GJB1 interactions 6.962E-4 2.903E-2
2.266E-1
9.579E-1
 2 14
34 int:PLN PLN interactions 8.018E-4 3.245E-2
2.533E-1
1.000E0
 2 15
35 int:HELZ2 HELZ2 interactions 9.147E-4 3.596E-2
2.807E-1
1.000E0
 2 16
36 int:PFKL PFKL interactions 9.742E-4 3.724E-2
2.906E-1
1.000E0
 3 69
37 int:PRKAR2A PRKAR2A interactions 1.102E-3 3.992E-2
3.115E-1
1.000E0
 3 72
38 int:PFKM PFKM interactions 1.102E-3 3.992E-2
3.115E-1
1.000E0
 3 72
39 int:MAFA MAFA interactions 1.296E-3 4.574E-2
3.570E-1
1.000E0
 2 19
40 int:AKAP7 AKAP7 interactions 1.438E-3 4.855E-2
3.789E-1
1.000E0
 2 20
41 int:CDC34 CDC34 interactions 1.447E-3 4.855E-2
3.789E-1
1.000E0
 5 296
Show 36 more annotations

10: Cytoband [Display Chart] 50 input genes in category / 48 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 6q22.1 6q22.1 8.645E-4 1.154E-2
5.146E-2
 4.150E-2 2 30
2 3p11 3p11 1.443E-3 1.154E-2
5.146E-2
6.924E-2
 1 1
3 7p15.3-p15.1 7p15.3-p15.1 1.443E-3 1.154E-2
5.146E-2
6.924E-2
 1 1
4 1p36.23-p33 1p36.23-p33 1.443E-3 1.154E-2
5.146E-2
6.924E-2
 1 1
5 10p15.3-p15.2 10p15.3-p15.2 1.443E-3 1.154E-2
5.146E-2
6.924E-2
 1 1
6 9q21.3-q22.2 9q21.3-q22.2 1.443E-3 1.154E-2
5.146E-2
6.924E-2
 1 1
7 3p22-p21 3p22-p21 2.883E-3 1.538E-2
6.856E-2
1.384E-1
 1 2
8 3q24-q25.1 3q24-q25.1 2.883E-3 1.538E-2
6.856E-2
1.384E-1
 1 2
9 11q13.4-q13.5 11q13.4-q13.5 2.883E-3 1.538E-2
6.856E-2
1.384E-1
 1 2
10 2q36-q37 2q36-q37 4.322E-3 1.596E-2
7.115E-2
2.074E-1
 1 3
11 3p26-p25 3p26-p25 4.322E-3 1.596E-2
7.115E-2
2.074E-1
 1 3
12 13q12.1 13q12.1 4.322E-3 1.596E-2
7.115E-2
2.074E-1
 1 3
13 3q26.1-q26.2 3q26.1-q26.2 4.322E-3 1.596E-2
7.115E-2
2.074E-1
 1 3
14 4q28-q31 4q28-q31 8.625E-3 2.957E-2
1.318E-1
4.140E-1
 1 6
15 10q23.3 10q23.3 1.148E-2 3.445E-2
1.536E-1
5.512E-1
 1 8
16 5q11.1 5q11.1 1.148E-2 3.445E-2
1.536E-1
5.512E-1
 1 8
Show 11 more annotations

11: Transcription Factor Binding Site [Display Chart] 39 input genes in category / 253 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$HNF4 01 V$HNF4 01 1.790E-4 4.528E-2
2.768E-1
 4.528E-2 6 213

12: Gene Family [Display Chart] 34 input genes in category / 25 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 542 Endogenous ligands genenames.org 2.322E-7 5.806E-6 2.215E-5 5.806E-6 7 237
2 1077 6-phosphofructo-2-kinases/fructose-2,6-biphosphatases genenames.org 2.029E-5 2.536E-4 9.678E-4 5.073E-4 2 4
3 269 Glucagon receptor family genenames.org 5.061E-5 4.217E-4 1.609E-3 1.265E-3 2 6
4 522 LIM class homeoboxes genenames.org 2.211E-4 1.382E-3 5.273E-3 5.528E-3 2 12
5 71 Nuclear hormone receptors genenames.org 3.773E-3 1.886E-2
7.199E-2
9.432E-2
 2 49
6 1074 Glucose 6-phosphatases, catalytic genenames.org 5.596E-3 2.166E-2
8.266E-2
1.399E-1
 1 3
7 752 Solute carriers genenames.org 6.065E-3 2.166E-2
8.266E-2
1.516E-1
 4 395
8 1227 HRAS like suppressor family genenames.org 9.310E-3 2.909E-2
1.110E-1
2.327E-1
 1 5
9 1205 DASH family genenames.org 1.301E-2 3.614E-2
1.379E-1
3.253E-1
 1 7
10 1153 Regulatory factor X family genenames.org 1.486E-2 3.714E-2
1.417E-1
3.714E-1
 1 8
11 436 Glycosyltransferase family 8 genenames.org 1.670E-2 3.795E-2
1.448E-1
4.174E-1
 1 9
Show 6 more annotations

13: Coexpression [Display Chart] 51 input genes in category / 3472 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5957 Genes specifically up-regulated in pancreatic beta cells. MSigDB H: Hallmark Gene Sets (v6.0) 2.904E-12 7.771E-9 6.784E-8 1.008E-8 7 40
2 M2270 Genes up-regulated during adipogenesis of 3T3-L1 cells (fibroblast). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.476E-12 7.771E-9 6.784E-8 1.554E-8 6 21
3 M1645 Adipocyte genes induced in 3T3-L1 cells (adipocyte) by constitutively active PPARG [GeneID=5468] or its agonist, TZD [PubChem=5437]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.580E-10 2.986E-7 2.607E-6 8.958E-7 5 17
4 15618438-Table1 Rat Lung not cancer Espinoza05 56genes GeneSigDB 3.587E-10 3.114E-7 2.718E-6 1.246E-6 6 41
5 M13448 Genes involved in gluconeogenesis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.190E-9 5.687E-6 4.965E-5 2.844E-5 5 32
6 M2460 Genes downregulated in the postnatal day 3 pancreata with impaired function of GLIS3 [GeneID=169792]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.758E-8 1.017E-5 8.882E-5 6.104E-5 5 37
7 M1451 Top 100 probe sets contrubuting to the negative side of the 2nd principal component; associated with adipocytic differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.246E-8 1.114E-5 9.727E-5 7.799E-5 6 80
8 M1555 Adipocyte abundant genes down-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.018E-8 1.310E-5 1.144E-4 1.048E-4 6 84
9 M16111 Genes involved in glycolysis; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.219E-7 4.702E-5 4.105E-4 4.232E-4 4 21
10 M2396 Genes down-regulated in pancreatic islets upon knockout of HNF1A [GeneID=6927]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.442E-7 5.007E-5 4.371E-4 5.007E-4 6 109
11 M5905 Genes up-regulated during adipocyte differentiation (adipogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 2.724E-7 8.597E-5 7.505E-4 9.457E-4 7 200
12 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 3.931E-7 1.137E-4 9.930E-4 1.365E-3 9 433
13 M2420 Genes with promoters bound by both PPARG and RXRA [GeneID=5468, 6256] at 8 (but not 0) day time point of adipocyte differentiation of 3T3-L1 cells (preadipocyte) and that were newly modified by H4K20me1. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.796E-7 2.082E-4 1.818E-3 2.707E-3 6 145
14 M9911 Genes negatively correlated with recurrence free survival in patients with hepatitis B-related (HBV) hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.029E-7 2.239E-4 1.955E-3 3.135E-3 5 80
15 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 1.038E-6 2.403E-4 2.097E-3 3.604E-3 7 244
16 M7517 Genes up-regulated in the luminal A subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.152E-6 2.500E-4 2.182E-3 3.999E-3 5 84
17 M13449 Genes down-regulated in hepatoblastoma samples compared to normal liver tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.891E-6 3.861E-4 3.371E-3 6.565E-3 7 267
18 M1524 Adipocyte abundant genes down-regulated in 3T3-L1 cells (fibroblasts induced to differentiate to adipocytes) in response to troglitazone [PubChem=5591] and TNF [GeneID=7124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.203E-6 4.249E-4 3.709E-3 7.648E-3 4 42
19 M1675 Selected genes up-regulated during differentiation of 3T3-L1 cells (fibroblast) into adipocytes in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.123E-6 7.534E-4 6.577E-3 1.431E-2 4 49
20 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v6.0) 5.042E-6 8.753E-4 7.641E-3 1.751E-2 6 200
21 18310505-Table1 Human StemCell Matushansky08 69genes GeneSigDB 6.572E-6 1.087E-3 9.485E-3 2.282E-2 4 55
22 19061838-TableS3 Human Viral Cairo08 588genes GeneSigDB 7.597E-6 1.199E-3 1.047E-2 2.638E-2 8 466
23 M2432 Genes up-regulated during adipogenic differentiation of 3T3-L1 cells (preadipocyte) and down-regulated by troglitazone [PubChem=5591]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.536E-6 1.440E-3 1.257E-2 3.311E-2 3 19
24 M10376 Genes involved in glycogen metabolism; based on literature and sequence annotation resources and converted to Affymetrix HG-U133A probe sets. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.305E-5 1.888E-3 1.648E-2 4.530E-2 3 21
25 M11640 Genes down-regulated in hepatocellular carcinoma (HCC) induced by ciprofibrate [PubChem=2763]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.364E-5 1.895E-3 1.654E-2 4.736E-2 4 66
26 M2424 Genes up-regulated in neonatal cardiac myocytes upon knockdown of BCL3 [GeneID=602] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.437E-5 1.915E-3 1.672E-2 4.991E-2 7 364
27 M1432 Top genes down-regulated at day 5 of Cre-Lox induced APC [GeneID=324] knockout in the intestine. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.489E-5 1.915E-3 1.672E-2
5.170E-2
 7 366
28 16618758-Table1 Mouse StemCell Lien06 29genes GeneSigDB 2.242E-5 2.741E-3 2.393E-2
7.786E-2
 3 25
29 M2584 Genes down-regulated in the ventricles of healthy hearts, compared to atria. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.290E-5 2.741E-3 2.393E-2
7.950E-2
 6 261
30 M1286 Genes from 'subtype S3' signature of hepatocellular carcinoma (HCC): hepatocyte differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.547E-5 2.948E-3 2.574E-2
8.844E-2
 6 266
31 M1820 Genes central for female fertility pathways, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.541E-5 3.965E-3 3.462E-2
1.229E-1
 3 29
32 M215 Selected genes up-regulated in prostate tumors developed by transgenic mice overexpressing VAV3 [GeneID=10451] in prostate epithelium. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.452E-5 4.720E-3 4.120E-2
1.546E-1
 4 89
33 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.486E-5 4.720E-3 4.120E-2
1.558E-1
 7 435
34 16423883-Table3 Mouse Liver Jeong06 39genes GeneSigDB 5.254E-5 5.355E-3 4.675E-2
1.824E-1
 3 33
35 M6145 Genes highly expressed in hepatocellular carcinoma with good survival. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.398E-5 5.355E-3 4.675E-2
1.874E-1
 5 185
36 19808960-Table2 Human Kidney Moore09 38genes GeneSigDB 5.753E-5 5.549E-3 4.844E-2
1.998E-1
 3 34
37 M2652 Genes down-regulated in MCF-7 cells (breast cancer) over-expressing CCND1 [Gene ID=595] gene. MSigDB C6: Oncogenic Signatures (v6.0) 6.280E-5 5.893E-3
5.145E-2
2.180E-1
 5 191
38 15906272-Table4 Mouse StemCell Greijer05 45genes UpRegulatedbyHypoxia GeneSigDB 6.843E-5 6.092E-3
5.319E-2
2.376E-1
 3 36
39 15906272-Table1 Mouse StemCell Greijer05 45genes UpRegulatedunderHypoxia GeneSigDB 6.843E-5 6.092E-3
5.319E-2
2.376E-1
 3 36
40 15845616-Table4 Mouse Uterine Jeong05 121genes GeneSigDB 7.302E-5 6.161E-3
5.378E-2
2.535E-1
 4 101
41 M2026 Genes up-regulated in mesenchymal stem cells during late phase of adipogenesis, defined as days 7 to 14 of culturing with adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.587E-5 6.161E-3
5.378E-2
2.634E-1
 4 102
42 M8263 Genes up-regulated in B lymphocytes stimulated by anti-IgM for 3h: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.625E-5 6.161E-3
5.378E-2
2.647E-1
 5 199
43 M8850 Genes up-regulated in multipotent progenitors versus RAG2 [GeneID=5897] knockout NK cells. MSigDB C7: Immunologic Signatures (v6.0) 7.808E-5 6.161E-3
5.378E-2
2.711E-1
 5 200
44 M8846 Genes down-regulated in NK cells: RAG2 [GeneID=5897] knockout versus RAG2 and ETS1 [GeneID=5897;2113] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.808E-5 6.161E-3
5.378E-2
2.711E-1
 5 200
45 16237459-TableS2 Mouse Lung Kasper05 71genes GeneSigDB 8.061E-5 6.219E-3
5.429E-2
2.799E-1
 3 38
46 15845616-SuppTable3 Mouse Uterine Jeong05 634genes GeneSigDB 8.545E-5 6.449E-3
5.630E-2
2.967E-1
 7 482
47 M4562 Genes up-regulated during in vitro maturation of CD14+ [GeneID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.168E-4 8.463E-3
7.388E-2
4.057E-1
 4 114
48 M1572 Up-regulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction diet since young adulthood. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.170E-4 8.463E-3
7.388E-2
4.062E-1
 3 43
49 16024625-SuppTable2a Human Colon Craene05 185genes GeneSigDB 1.719E-4 1.218E-2
1.063E-1
5.968E-1
 4 126
50 M14072 Genes regulated by hypoxia, based on literature searches. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.906E-4 1.323E-2
1.155E-1
6.617E-1
 5 242
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 51 input genes in category / 3213 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BM Top 100 - adipose tissue subcutaneous BM Top 100 - adipose tissue subcutaneous Body Map 1.667E-8 5.357E-5 4.635E-4 5.357E-5 6 72
2 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/1/3 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/1/3 TCGA-Pancreas 2.255E-7 3.623E-4 3.135E-3 7.246E-4 6 111
3 BM Top 100 - liver BM Top 100 - liver Body Map 1.199E-6 1.284E-3 1.111E-2 3.852E-3 5 80
4 adipose tissue adipose tissue Human Protein Atlas 2.007E-6 1.473E-3 1.275E-2 6.448E-3 6 161
5 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver/hepatocyte Tabula Muris Consortium 2.314E-6 1.473E-3 1.275E-2 7.435E-3 6 165
6 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal and Lobular Carcinoma/6 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal and Lobular Carcinoma/6 TCGA-Breast 2.751E-6 1.473E-3 1.275E-2 8.840E-3 6 170
7 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/6 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/6 TCGA-Breast 4.080E-6 1.873E-3 1.620E-2 1.311E-2 6 182
8 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/type B pancreatic cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/type B pancreatic cell Tabula Muris Consortium 5.225E-6 2.099E-3 1.816E-2 1.679E-2 6 190
9 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 1000 k4 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.666E-6 2.737E-3 2.368E-2 2.463E-2 4 54
10 BM Top 100 - adipose tissue BM Top 100 - adipose tissue Body Map 2.162E-5 6.947E-3
6.011E-2
6.947E-2
 4 70
11 gudmap developingKidney e15.5 S-shaped body 100 k2 DevelopingKidney e15.5 S-shaped body emap-27855 k-means-cluster#2 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 2.665E-5 7.216E-3
6.243E-2
8.562E-2
 3 25
12 BM Top 100 - adipose tissue omental BM Top 100 - adipose tissue omental Body Map 2.695E-5 7.216E-3
6.243E-2
8.659E-2
 4 74
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T regulatory/Kidney Normal-Cortex post-natal kidney T regulatory Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T regulatory/Kidney Normal-Cortex post-natal kidney T regulatory Adult, Development, and Cancer types 3.007E-5 7.433E-3
6.431E-2
9.663E-2
 3 26
14 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Acinar Adenocarcinoma/5 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Acinar Adenocarcinoma/5 TCGA-Lung 4.748E-5 1.044E-2
9.029E-2
1.526E-1
 5 170
15 gudmap developingKidney e15.5 Pelvic Mesenchyme 100 DevelopingKidney e15.5 Pelvic Mesenchyme emap-8241 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.872E-5 1.044E-2
9.029E-2
1.565E-1
 4 86
16 gudmap developingKidney e15.5 Proximal Tubules 500 k4 DevelopingKidney e15.5 Proximal Tubules emap-28005 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.192E-5 1.349E-2
1.168E-1
2.311E-1
 4 95
17 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic D cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic D cell Tabula Muris Consortium 7.463E-5 1.349E-2
1.168E-1
2.398E-1
 5 187
18 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/epithelial cell of proximal tubule Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/epithelial cell of proximal tubule Tabula Muris Consortium 7.848E-5 1.349E-2
1.168E-1
2.521E-1
 5 189
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex post-natal kidney Nephron epithelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex post-natal kidney Nephron epithelium Adult, Development, and Cancer types 7.980E-5 1.349E-2
1.168E-1
2.564E-1
 2 6
20 gudmap developingKidney e15.5 Pelvic Mesenchyme 100 k1 DevelopingKidney e15.5 Pelvic Mesenchyme emap-8241 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.115E-4 1.707E-2
1.477E-1
3.584E-1
 2 7
21 gudmap developingKidney e15.5 Podocyte cells 100 k1 DevelopingKidney e15.5 Podocyte cells emap-27915 k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.115E-4 1.707E-2
1.477E-1
3.584E-1
 2 7
22 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 1.177E-4 1.719E-2
1.487E-1
3.782E-1
 5 206
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Normal-Cortex post-natal kidney MNP RCC2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC2/Kidney Normal-Cortex post-natal kidney MNP RCC2 Adult, Development, and Cancer types 1.293E-4 1.795E-2
1.553E-1
4.156E-1
 3 42
24 BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.A.Gja1 Astrocyte.astrocytes.A.Gja1 Subtype Astrocyte.astrocytes.A.Gja1.Htra1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Astrocyte.astrocytes.A.Gja1 Astrocyte.astrocytes.A.Gja1 Subtype Astrocyte.astrocytes.A.Gja1.Htra1 Top 200 Genes BrainMap 1.407E-4 1.795E-2
1.553E-1
4.522E-1
 6 342
25 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Adenocarcinoma-NOS/1/3 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Adenocarcinoma-NOS/1/3 TCGA-Pancreas 1.410E-4 1.795E-2
1.553E-1
4.531E-1
 4 113
26 Mouse Cell Atlas Mouse Regional GI Enterocytes Enteroendocrine Enteroendocrine Subtype Enteroendocrine Jejunum Top 200 Genes Mouse Cell Atlas Mouse Regional GI Enterocytes Enteroendocrine Enteroendocrine Subtype Enteroendocrine Jejunum Top 200 Genes Mouse Cell Atlas 1.453E-4 1.795E-2
1.553E-1
4.668E-1
 6 344
27 gudmap developingKidney e15.5 S-shaped body 200 k5 DevelopingKidney e15.5 S-shaped body emap-27855 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.591E-4 1.893E-2
1.638E-1
5.111E-1
 3 45
28 gudmap developingLowerUrinaryTract e15.5 Urothelium 500 k3 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.894E-4 2.112E-2
1.828E-1
6.086E-1
 4 122
29 gudmap developingKidney e15.5 stage III -IV renal corpusc 100 k5 DevelopingKidney e15.5 stage III -IV renal corpusc emap-27945 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.907E-4 2.112E-2
1.828E-1
6.126E-1
 2 9
30 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Lobular Carcinoma/6 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Lobular Carcinoma/6 TCGA-Breast 2.179E-4 2.317E-2
2.005E-1
7.002E-1
 3 50
31 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/4/0 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/4/0 TCGA-Pancreas 2.277E-4 2.317E-2
2.005E-1
7.316E-1
 4 128
32 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Medulla post-natal kidney Renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal-Medulla post-natal kidney Renal cell carcinoma Adult, Development, and Cancer types 2.380E-4 2.317E-2
2.005E-1
7.646E-1
 2 10
33 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP3/Kidney Normal-Cortex post-natal kidney MNP3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP3/Kidney Normal-Cortex post-natal kidney MNP3 Adult, Development, and Cancer types 2.380E-4 2.317E-2
2.005E-1
7.646E-1
 2 10
34 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney Tabula Muris Consortium 2.636E-4 2.453E-2
2.123E-1
8.471E-1
 4 133
35 gudmap developingLowerUrinaryTract P2 bladder stroma (LCM) 500 DevelopingLowerUrinaryTract P2 bladder stroma (LCM) emap-30396 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.781E-4 2.453E-2
2.123E-1
8.935E-1
 6 388
36 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/1/3 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/1/3 TCGA-Mesothelium 2.791E-4 2.453E-2
2.123E-1
8.967E-1
 4 135
37 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex post-natal kidney R U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Cortex post-natal kidney R U Adult, Development, and Cancer types 2.904E-4 2.453E-2
2.123E-1
9.331E-1
 2 11
38 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell Adult, Development, and Cancer types 2.904E-4 2.453E-2
2.123E-1
9.331E-1
 2 11
39 gudmap developingKidney e15.5 early proxim tubul 500 DevelopingKidney e15.5 early proxim tubul emap-28005 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.978E-4 2.453E-2
2.123E-1
9.568E-1
 6 393
40 gudmap developingKidney e15.5 cortic collect duct 1000 k1 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.216E-4 2.583E-2
2.235E-1
1.000E0
 3 57
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney NephrogenicRest Wilms CD8 T cell/Kidney NephrogenicRest Wilms IN10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney CD8 T cell/Kidney NephrogenicRest Wilms CD8 T cell/Kidney NephrogenicRest Wilms IN10 Adult, Development, and Cancer types 3.480E-4 2.630E-2
2.276E-1
1.000E0
 2 12
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Cortex post-natal kidney U U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Cortex post-natal kidney U U Adult, Development, and Cancer types 3.480E-4 2.630E-2
2.276E-1
1.000E0
 2 12
43 gudmap kidney adult JuxtaGlom Ren1 Captopr 500 kidney adult JuxtaGlom Ren1 Captopr top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.589E-4 2.630E-2
2.276E-1
1.000E0
 6 407
44 gudmap developingKidney e14.5 whole kidney - wildtype 1000 k5 DevelopingKidney e14.5 whole kidney - wildtype emap-6674 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.912E-4 2.630E-2
2.276E-1
1.000E0
 5 267
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal-Cortex post-natal kidney EN-A Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney Normal-Cortex post-natal kidney EN-A Adult, Development, and Cancer types 4.106E-4 2.630E-2
2.276E-1
1.000E0
 2 13
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP/Kidney Normal-Cortex Wilms MNP Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP/Kidney Normal-Cortex Wilms MNP Adult, Development, and Cancer types 4.106E-4 2.630E-2
2.276E-1
1.000E0
 2 13
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal-Cortex post-natal kidney MNP1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal-Cortex post-natal kidney MNP1 Adult, Development, and Cancer types 4.106E-4 2.630E-2
2.276E-1
1.000E0
 2 13
48 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC1/Kidney Normal-Cortex post-natal kidney MNP RCC1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP RCC1/Kidney Normal-Cortex post-natal kidney MNP RCC1 Adult, Development, and Cancer types 4.106E-4 2.630E-2
2.276E-1
1.000E0
 2 13
49 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/3/3 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/3/3 TCGA-Pancreas 4.164E-4 2.630E-2
2.276E-1
1.000E0
 4 150
50 liver liver Human Protein Atlas 4.187E-4 2.630E-2
2.276E-1
1.000E0
 6 419
Show 45 more annotations

15: Computational [Display Chart] 39 input genes in category / 171 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M18792 MODULE 306 Glycolysis and TCA cycle. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.736E-6 4.679E-4 2.677E-3 4.679E-4 4 26

16: MicroRNA [Display Chart] 51 input genes in category / 1006 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1280:mirSVR lowEffct hsa-miR-1280:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 6.815E-6 6.856E-3
5.136E-2
 6.856E-3 5 372
2 hsa-miR-5692a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.406E-5 1.600E-2
1.198E-1
5.438E-2
 4 289
3 hsa-miR-1185-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.146E-5 1.600E-2
1.198E-1
8.195E-2
 3 117
4 hsa-miR-1185-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.781E-5 1.600E-2
1.198E-1
8.834E-2
 3 120
5 hsa-miR-3163:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.035E-4 1.600E-2
1.198E-1
1.041E-1
 4 342
6 AGGGCAG,MIR-18A:MSigDB AGGGCAG,MIR-18A:MSigDB MSigDB 1.088E-4 1.600E-2
1.198E-1
1.094E-1
 3 129
7 hsa-miR-133a-3p:Functional MTI Functional MTI miRTarbase 1.113E-4 1.600E-2
1.198E-1
1.120E-1
 3 130
8 hsa-miR-423-5p:TargetScan hsa-miR-423-5p TargetScan 1.942E-4 2.442E-2
1.830E-1
1.954E-1
 3 157
9 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 2.659E-4 2.972E-2
2.226E-1
2.675E-1
 4 438
10 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 3.122E-4 3.125E-2
2.341E-1
3.141E-1
 4 457
11 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.498E-4 3.125E-2
2.341E-1
3.519E-1
 4 471
12 hsa-miR-219-5p:mirSVR highEffct hsa-miR-219-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 3.728E-4 3.125E-2
2.341E-1
3.750E-1
 4 479
13 hsa-miR-6734-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.347E-4 4.138E-2
3.100E-1
5.379E-1
 3 222
Show 8 more annotations

17: Drug [Display Chart] 51 input genes in category / 11676 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000439177 glycogen Stitch 6.323E-35 7.383E-31 7.341E-30 7.383E-31 28 443
2 CID000005505 tolbutamide Stitch 7.554E-25 4.410E-21 4.385E-20 8.820E-21 18 198
3 CID000000483 AC1L19C4 Stitch 1.530E-24 5.954E-21 5.920E-20 1.786E-20 14 69
4 CID000000861 D-triiodothyronine Stitch 3.372E-22 9.843E-19 9.786E-18 3.937E-18 20 409
5 CID000181487 AC1L494B Stitch 9.457E-22 2.208E-18 2.196E-17 1.104E-17 12 53
6 ctd:D005632 Fructose CTD 2.478E-21 4.156E-18 4.132E-17 2.893E-17 17 248
7 ctd:D005227 Fatty Acids CTD 2.492E-21 4.156E-18 4.132E-17 2.909E-17 12 57
8 CID000003758 IBMX Stitch 6.077E-20 8.869E-17 8.818E-16 7.095E-16 18 368
9 CID000003426 Laevuflex Stitch 5.189E-19 6.732E-16 6.693E-15 6.058E-15 16 272
10 CID000000719 AC1Q6RZ4 Stitch 6.692E-19 7.813E-16 7.768E-15 7.813E-15 13 123
11 CID000000754 glycerol-3-phosphate Stitch 1.242E-18 1.318E-15 1.311E-14 1.450E-14 15 226
12 CID000000208 glucose-6-P Stitch 1.881E-18 1.830E-15 1.820E-14 2.196E-14 17 366
13 CID000065823 sulfenamido-sulfonamides Stitch 8.309E-18 7.463E-15 7.420E-14 9.702E-14 8 17
14 CID000004829 pioglitazone Stitch 9.378E-18 7.821E-15 7.776E-14 1.095E-13 16 326
15 CID000001060 pyruvic acid Stitch 2.224E-17 1.731E-14 1.721E-13 2.597E-13 17 424
16 CID000000603 allulose 6-phosphate Stitch 2.659E-17 1.940E-14 1.929E-13 3.104E-13 13 162
17 CID000000525 malate Stitch 3.451E-17 2.370E-14 2.356E-13 4.029E-13 14 219
18 CID004369452 T2 D Stitch 6.780E-17 4.398E-14 4.373E-13 7.917E-13 12 127
19 CID000000612 lactate Stitch 8.981E-17 5.519E-14 5.488E-13 1.049E-12 17 461
20 CID000000751 glyceraldehyde Stitch 2.251E-16 1.314E-13 1.307E-12 2.629E-12 12 140
21 ctd:D019301 Oleic Acid CTD 2.649E-16 1.473E-13 1.465E-12 3.093E-12 11 100
22 CID011819083 1 sulfonylurea Stitch 2.920E-16 1.550E-13 1.541E-12 3.410E-12 12 143
23 ctd:C076126 disodium (R,R)-5-(2-((2-(3-chlorophenyl)-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxole-2,3-dicarboxylate CTD 5.260E-16 2.670E-13 2.655E-12 6.141E-12 8 26
24 CID000005437 thiazolidinedione Stitch 7.968E-16 3.774E-13 3.753E-12 9.303E-12 14 274
25 CID000001005 phosphoenolpyruvate Stitch 8.082E-16 3.774E-13 3.753E-12 9.436E-12 13 210
26 CID000011146 tristearin Stitch 9.272E-16 4.164E-13 4.140E-12 1.083E-11 14 277
27 CID000000717 AC1Q6SXM Stitch 1.547E-15 6.690E-13 6.651E-12 1.806E-11 10 79
28 CID000004091 metformin Stitch 3.495E-15 1.457E-12 1.449E-11 4.081E-11 13 235
29 ctd:C108709 oleoyl-estrone CTD 3.850E-15 1.550E-12 1.541E-11 4.495E-11 9 55
30 CID000000716 2-hexulofuranose Stitch 4.776E-15 1.859E-12 1.848E-11 5.576E-11 10 88
31 ctd:D002211 Capsaicin CTD 6.051E-15 2.279E-12 2.266E-11 7.066E-11 16 492
32 CID000000718 fructose-1,6-diphosphate sodium salt Stitch 2.766E-14 1.009E-11 1.003E-10 3.230E-10 11 151
33 CID000398798 TC-3 Stitch 3.353E-14 1.186E-11 1.179E-10 3.914E-10 9 69
34 CID000002436 BRL 37344 Stitch 3.869E-14 1.329E-11 1.321E-10 4.517E-10 8 42
35 CID000000965 mangrove Stitch 6.119E-14 2.041E-11 2.029E-10 7.144E-10 15 468
36 ctd:D001629 Bezafibrate CTD 1.015E-13 3.291E-11 3.272E-10 1.185E-9 12 232
37 CID000121891 mitiglinide Stitch 1.546E-13 4.879E-11 4.851E-10 1.805E-9 7 27
38 CID000119371 AC1L3OOT Stitch 1.736E-13 5.335E-11 5.304E-10 2.027E-9 8 50
39 CID000017513 acadesine Stitch 1.915E-13 5.735E-11 5.702E-10 2.236E-9 10 126
40 CID006918373 oleoyl-estrone Stitch 2.058E-13 6.007E-11 5.972E-10 2.403E-9 7 28
41 CID000099058 6-o-phosphonohexose Stitch 2.621E-13 7.465E-11 7.422E-10 3.061E-9 11 185
42 CID000000481 1-o-phosphonohex-2-ulose Stitch 2.708E-13 7.528E-11 7.485E-10 3.162E-9 7 29
43 CID000003476 glimepiride Stitch 3.342E-13 9.076E-11 9.024E-10 3.903E-9 8 54
44 CID000128440 AD-5075 Stitch 4.504E-13 1.195E-10 1.188E-9 5.259E-9 6 15
45 ctd:D009525 Niacin CTD 5.184E-13 1.345E-10 1.337E-9 6.053E-9 10 139
46 CID000000970 oxaloacetate Stitch 5.529E-13 1.403E-10 1.395E-9 6.455E-9 11 198
47 ctd:C500085 muraglitazar CTD 6.598E-13 1.639E-10 1.630E-9 7.703E-9 14 447
48 ctd:C005274 naringin CTD 8.514E-13 2.071E-10 2.059E-9 9.941E-9 10 146
49 CID000000670 dihydroxyacetone Stitch 8.872E-13 2.114E-10 2.102E-9 1.036E-8 9 98
50 CID000065779 glipentide Stitch 9.494E-13 2.217E-10 2.204E-9 1.109E-8 5 7
Show 45 more annotations

18: Disease [Display Chart] 51 input genes in category / 1427 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0020459 Hyperinsulinism DisGeNET Curated 2.947E-18 4.205E-15 3.297E-14 4.205E-15 18 327
2 C0028756 Obesity, Morbid DisGeNET Curated 5.877E-16 2.846E-13 2.232E-12 8.386E-13 12 109
3 C0271650 Impaired glucose tolerance DisGeNET Curated 5.983E-16 2.846E-13 2.232E-12 8.538E-13 16 303
4 C0020456 Hyperglycemia DisGeNET Curated 8.267E-16 2.949E-13 2.312E-12 1.180E-12 18 450
5 C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 1.219E-15 3.480E-13 2.728E-12 1.740E-12 16 317
6 C0020615 Hypoglycemia DisGeNET Curated 2.065E-15 4.912E-13 3.851E-12 2.947E-12 14 210
7 C0011853 Diabetes Mellitus, Experimental DisGeNET Curated 2.349E-14 4.788E-12 3.754E-11 3.351E-11 11 107
8 C0342276 Maturity onset diabetes mellitus in young DisGeNET Curated 9.800E-14 1.748E-11 1.371E-10 1.398E-10 10 85
9 C0021670 insulinoma DisGeNET Curated 3.032E-13 4.418E-11 3.464E-10 4.326E-10 12 182
10 C0497406 Overweight DisGeNET Curated 3.096E-13 4.418E-11 3.464E-10 4.418E-10 13 238
11 C2711227 Steatohepatitis DisGeNET Curated 9.445E-13 1.225E-10 9.607E-10 1.348E-9 16 487
12 C0021655 Insulin Resistance DisGeNET Curated 1.055E-12 1.254E-10 9.833E-10 1.505E-9 9 72
13 C0242339 Dyslipidemias DisGeNET Curated 1.489E-12 1.634E-10 1.281E-9 2.124E-9 12 208
14 C0015695 Fatty Liver DisGeNET Curated 7.050E-12 7.186E-10 5.634E-9 1.006E-8 14 380
15 C0025517 Metabolic Diseases DisGeNET Curated 1.184E-11 1.127E-9 8.834E-9 1.690E-8 14 395
16 C2362324 Pediatric Obesity DisGeNET Curated 4.409E-11 3.933E-9 3.084E-8 6.292E-8 8 70
17 C3888018 Congenital Hyperinsulinism DisGeNET Curated 6.948E-11 5.832E-9 4.573E-8 9.914E-8 6 23
18 C0032460 Polycystic Ovary Syndrome DisGeNET Curated 1.571E-10 1.245E-8 9.764E-8 2.242E-7 14 480
19 C0023787 Lipodystrophy DisGeNET Curated 6.879E-10 5.166E-8 4.051E-7 9.816E-7 8 98
20 C3241937 Nonalcoholic Steatohepatitis DisGeNET BeFree 2.337E-9 1.668E-7 1.307E-6 3.335E-6 9 168
21 C3714619 Insulin resistance syndrome DisGeNET BeFree 3.450E-9 2.345E-7 1.838E-6 4.924E-6 6 42
22 OMIN:601665 OBESITY OMIM 6.384E-9 4.141E-7 3.247E-6 9.111E-6 5 22
23 C0020473 Hyperlipidemia DisGeNET Curated 1.395E-8 8.656E-7 6.787E-6 1.991E-5 9 206
24 cv:C0011860 Diabetes mellitus type 2 Clinical Variations 2.349E-8 1.397E-6 1.095E-5 3.352E-5 5 28
25 C0085207 Gestational Diabetes DisGeNET Curated 4.227E-8 2.413E-6 1.892E-5 6.033E-5 4 12
26 OMIN:125853 DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM OMIM 6.557E-8 3.599E-6 2.822E-5 9.357E-5 5 34
27 C0017689 Glucagonoma DisGeNET Curated 8.509E-8 4.395E-6 3.446E-5 1.214E-4 4 14
28 C1561643 Chronic Kidney Diseases DisGeNET Curated 8.624E-8 4.395E-6 3.446E-5 1.231E-4 10 340
29 C1522137 Hypertriglyceridemia result DisGeNET Curated 1.020E-7 4.930E-6 3.866E-5 1.455E-4 5 37
30 C0019209 Hepatomegaly DisGeNET Curated 1.036E-7 4.930E-6 3.866E-5 1.479E-4 9 260
31 C0158981 Neonatal diabetes mellitus DisGeNET BeFree 1.172E-7 5.393E-6 4.229E-5 1.672E-4 5 38
32 cv:C0028754 Obesity Clinical Variations 1.540E-7 6.867E-6 5.385E-5 2.198E-4 4 16
33 C0020474 Hyperlipidemia, Familial Combined DisGeNET Curated 1.674E-7 7.239E-6 5.676E-5 2.389E-4 6 79
34 C0020550 Hyperthyroidism DisGeNET Curated 3.901E-7 1.637E-5 1.284E-4 5.567E-4 6 91
35 C3554224 LEPTIN DEFICIENCY OR DYSFUNCTION DisGeNET Curated 5.834E-7 2.313E-5 1.813E-4 8.326E-4 3 6
36 C1837802 Decreased serum leptin DisGeNET Curated 5.834E-7 2.313E-5 1.813E-4 8.326E-4 3 6
37 C0854110 Insulin resistant diabetes DisGeNET Curated 6.104E-7 2.354E-5 1.846E-4 8.710E-4 4 22
38 C0017919 Glycogen Storage Disease DisGeNET Curated 7.372E-7 2.768E-5 2.171E-4 1.052E-3 4 23
39 C0342277 Diabetes mellitus autosomal dominant type II (disorder) DisGeNET Curated 1.019E-6 3.728E-5 2.923E-4 1.454E-3 3 7
40 C1864903 Hyperinsulinaemic hypoglycaemia DisGeNET Curated 1.048E-6 3.740E-5 2.932E-4 1.496E-3 4 25
41 C0017979 Glycosuria DisGeNET Curated 1.950E-6 6.787E-5 5.321E-4 2.782E-3 4 29
42 C0362046 Prediabetes syndrome DisGeNET BeFree 2.105E-6 7.151E-5 5.607E-4 3.004E-3 5 67
43 C0342543 Precocious Puberty, Central DisGeNET Curated 2.434E-6 7.895E-5 6.190E-4 3.474E-3 3 9
44 C0240225 Liver mass DisGeNET BeFree 2.434E-6 7.895E-5 6.190E-4 3.474E-3 3 9
45 C0019158 Hepatitis DisGeNET Curated 3.721E-6 1.180E-4 9.253E-4 5.310E-3 8 297
46 C0162429 Malnutrition DisGeNET Curated 5.072E-6 1.573E-4 1.234E-3 7.237E-3 7 218
47 C4020778 maternal hyperglycemia DisGeNET Curated 6.333E-6 1.923E-4 1.508E-3 9.037E-3 3 12
48 C0006625 Cachexia DisGeNET Curated 6.729E-6 2.001E-4 1.569E-3 9.603E-3 6 148
49 C0349788 Arrhythmogenic Right Ventricular Dysplasia DisGeNET BeFree 8.086E-6 2.344E-4 1.838E-3 1.154E-2 4 41
50 C0232462 Decrease in appetite DisGeNET Curated 8.214E-6 2.344E-4 1.838E-3 1.172E-2 3 13
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