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1: GO: Molecular Function [Display Chart] 530 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044212 transcription regulatory region DNA binding 1.193E-24 2.701E-22 1.850E-21 6.323E-22 38 862
2 GO:0000975 regulatory region DNA binding 1.351E-24 2.701E-22 1.850E-21 7.159E-22 38 865
3 GO:0001067 regulatory region nucleic acid binding 1.529E-24 2.701E-22 1.850E-21 8.102E-22 38 868
4 GO:0003690 double-stranded DNA binding 4.543E-22 6.019E-20 4.124E-19 2.408E-19 35 824
5 GO:0000976 transcription regulatory region sequence-specific DNA binding 6.713E-20 7.116E-18 4.875E-17 3.558E-17 31 705
6 GO:1990837 sequence-specific double-stranded DNA binding 2.324E-19 2.053E-17 1.406E-16 1.232E-16 31 736
7 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding 2.838E-18 2.149E-16 1.472E-15 1.504E-15 29 678
8 GO:0008134 transcription factor binding 7.666E-18 5.079E-16 3.480E-15 4.063E-15 27 585
9 GO:0003682 chromatin binding 4.999E-17 2.944E-15 2.017E-14 2.650E-14 25 516
10 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding 5.555E-16 2.944E-14 2.017E-13 2.944E-13 26 632
11 GO:0001012 RNA polymerase II regulatory region DNA binding 6.963E-16 3.355E-14 2.298E-13 3.690E-13 26 638
12 GO:0001047 core promoter binding 1.775E-14 7.838E-13 5.370E-12 9.405E-12 15 165
13 GO:0001046 core promoter sequence-specific DNA binding 6.354E-14 2.590E-12 1.775E-11 3.368E-11 13 115
14 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding 8.694E-14 3.291E-12 2.255E-11 4.608E-11 19 358
15 GO:0000982 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding 1.590E-11 5.619E-10 3.850E-9 8.429E-9 17 365
16 GO:0000987 core promoter proximal region sequence-specific DNA binding 5.988E-10 1.983E-8 1.359E-7 3.173E-7 16 399
17 GO:0001159 core promoter proximal region DNA binding 6.439E-10 2.007E-8 1.375E-7 3.412E-7 16 401
18 GO:0001085 RNA polymerase II transcription factor binding 1.015E-9 2.990E-8 2.048E-7 5.381E-7 10 118
19 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding 1.892E-9 5.278E-8 3.616E-7 1.003E-6 13 259
20 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 2.917E-9 7.731E-8 5.297E-7 1.546E-6 8 66
21 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding 2.263E-8 5.710E-7 3.912E-6 1.199E-5 14 380
22 GO:0001158 enhancer sequence-specific DNA binding 4.576E-8 1.102E-6 7.552E-6 2.425E-5 8 93
23 GO:0035326 enhancer binding 1.277E-7 2.943E-6 2.016E-5 6.770E-5 8 106
24 GO:0000989 transcription factor activity, transcription factor binding 2.405E-7 5.312E-6 3.639E-5 1.275E-4 16 612
25 GO:0000988 transcription factor activity, protein binding 2.626E-7 5.566E-6 3.813E-5 1.392E-4 16 616
26 GO:0043425 bHLH transcription factor binding 5.973E-7 1.218E-5 8.342E-5 3.166E-4 5 30
27 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding 8.237E-7 1.599E-5 1.096E-4 4.366E-4 7 93
28 GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding 8.752E-7 1.599E-5 1.096E-4 4.638E-4 6 59
29 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding 8.752E-7 1.599E-5 1.096E-4 4.638E-4 6 59
30 GO:0033613 activating transcription factor binding 1.069E-6 1.888E-5 1.294E-4 5.665E-4 6 61
31 GO:0019900 kinase binding 1.249E-6 2.135E-5 1.463E-4 6.619E-4 16 693
32 GO:0070888 E-box binding 1.331E-6 2.205E-5 1.511E-4 7.055E-4 5 35
33 GO:0001102 RNA polymerase II activating transcription factor binding 2.031E-6 3.263E-5 2.235E-4 1.077E-3 5 38
34 GO:0019904 protein domain specific binding 2.539E-6 3.957E-5 2.711E-4 1.346E-3 16 732
35 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 2.637E-6 3.993E-5 2.735E-4 1.397E-3 6 71
36 GO:0003712 transcription cofactor activity 2.791E-6 4.110E-5 2.816E-4 1.479E-3 14 566
37 GO:0019901 protein kinase binding 8.229E-6 1.179E-4 8.075E-4 4.361E-3 14 622
38 GO:0003713 transcription coactivator activity 8.708E-6 1.215E-4 8.321E-4 4.615E-3 10 311
39 GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding 1.386E-5 1.883E-4 1.290E-3 7.345E-3 7 142
40 GO:0046982 protein heterodimerization activity 1.696E-5 2.248E-4 1.540E-3 8.991E-3 13 575
41 GO:0008140 cAMP response element binding protein binding 1.913E-5 2.473E-4 1.694E-3 1.014E-2 3 10
42 GO:0001221 transcription cofactor binding 2.159E-5 2.725E-4 1.867E-3 1.145E-2 4 30
43 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding 2.834E-5 3.493E-4 2.393E-3 1.502E-2 6 107
44 GO:0042826 histone deacetylase binding 4.258E-5 5.129E-4 3.514E-3 2.257E-2 6 115
45 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding 6.800E-5 8.009E-4 5.487E-3 3.604E-2 7 182
46 GO:0071837 HMG box domain binding 2.679E-4 3.087E-3 2.115E-2
1.420E-1
 3 23
47 GO:0070491 repressing transcription factor binding 3.384E-4 3.816E-3 2.614E-2
1.793E-1
 4 60
48 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding 4.263E-4 4.707E-3 3.225E-2
2.259E-1
 5 114
49 GO:0035035 histone acetyltransferase binding 5.972E-4 6.459E-3 4.425E-2
3.165E-1
 3 30
50 GO:0001618 virus receptor activity 6.436E-4 6.822E-3 4.674E-2
3.411E-1
 4 71
Show 45 more annotations

2: GO: Biological Process [Display Chart] 3498 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000122 negative regulation of transcription from RNA polymerase II promoter 2.534E-16 8.865E-13 7.746E-12 8.865E-13 29 810
2 GO:0008285 negative regulation of cell proliferation 8.083E-14 1.414E-10 1.235E-9 2.827E-10 25 718
3 GO:0002521 leukocyte differentiation 1.108E-12 1.292E-9 1.129E-8 3.877E-9 21 535
4 GO:0030097 hemopoiesis 4.166E-12 3.644E-9 3.183E-8 1.457E-8 25 858
5 GO:0002520 immune system development 6.688E-12 4.679E-9 4.088E-8 2.340E-8 26 956
6 GO:0048534 hematopoietic or lymphoid organ development 1.324E-11 7.718E-9 6.743E-8 4.631E-8 25 905
7 GO:0009314 response to radiation 1.205E-10 6.022E-8 5.262E-7 4.216E-7 18 481
8 GO:0048511 rhythmic process 1.624E-10 7.101E-8 6.205E-7 5.681E-7 16 368
9 GO:1903706 regulation of hemopoiesis 1.980E-10 7.697E-8 6.725E-7 6.927E-7 16 373
10 GO:1902105 regulation of leukocyte differentiation 3.699E-10 1.294E-7 1.130E-6 1.294E-6 14 278
11 GO:0048872 homeostasis of number of cells 4.459E-10 1.418E-7 1.239E-6 1.560E-6 14 282
12 GO:0050776 regulation of immune response 4.900E-10 1.428E-7 1.248E-6 1.714E-6 23 902
13 GO:0034097 response to cytokine 5.427E-10 1.460E-7 1.276E-6 1.898E-6 22 825
14 GO:0010942 positive regulation of cell death 1.122E-9 2.803E-7 2.449E-6 3.925E-6 20 699
15 GO:0002573 myeloid leukocyte differentiation 2.278E-9 5.152E-7 4.502E-6 7.968E-6 12 215
16 GO:0043065 positive regulation of apoptotic process 2.357E-9 5.152E-7 4.502E-6 8.244E-6 19 653
17 GO:0043068 positive regulation of programmed cell death 2.738E-9 5.634E-7 4.923E-6 9.578E-6 19 659
18 GO:0030099 myeloid cell differentiation 3.289E-9 6.391E-7 5.584E-6 1.150E-5 15 389
19 GO:0043620 regulation of DNA-templated transcription in response to stress 4.421E-9 8.024E-7 7.011E-6 1.546E-5 8 70
20 GO:0016032 viral process 4.588E-9 8.024E-7 7.011E-6 1.605E-5 20 759
21 GO:0044764 multi-organism cellular process 6.250E-9 1.041E-6 9.097E-6 2.186E-5 20 773
22 GO:0010243 response to organonitrogen compound 7.842E-9 1.247E-6 1.089E-5 2.743E-5 21 867
23 GO:0035710 CD4-positive, alpha-beta T cell activation 8.594E-9 1.307E-6 1.142E-5 3.006E-5 8 76
24 GO:0097193 intrinsic apoptotic signaling pathway 1.045E-8 1.522E-6 1.330E-5 3.654E-5 13 301
25 GO:0044419 interspecies interaction between organisms 1.315E-8 1.770E-6 1.546E-5 4.602E-5 20 808
26 GO:0044403 symbiosis, encompassing mutualism through parasitism 1.315E-8 1.770E-6 1.546E-5 4.602E-5 20 808
27 GO:0045637 regulation of myeloid cell differentiation 1.745E-8 2.261E-6 1.976E-5 6.105E-5 11 206
28 GO:0002761 regulation of myeloid leukocyte differentiation 2.644E-8 3.304E-6 2.886E-5 9.250E-5 9 124
29 GO:0045596 negative regulation of cell differentiation 4.277E-8 5.159E-6 4.508E-5 1.496E-4 18 699
30 GO:0001816 cytokine production 4.663E-8 5.437E-6 4.750E-5 1.631E-4 18 703
31 GO:0007159 leukocyte cell-cell adhesion 5.013E-8 5.657E-6 4.943E-5 1.754E-4 16 550
32 GO:0097190 apoptotic signaling pathway 5.196E-8 5.680E-6 4.963E-5 1.818E-4 17 628
33 GO:0045597 positive regulation of cell differentiation 5.536E-8 5.791E-6 5.060E-5 1.936E-4 21 971
34 GO:0071345 cellular response to cytokine stimulus 5.771E-8 5.791E-6 5.060E-5 2.019E-4 18 713
35 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 5.828E-8 5.791E-6 5.060E-5 2.039E-4 7 64
36 GO:0001817 regulation of cytokine production 5.960E-8 5.791E-6 5.060E-5 2.085E-4 17 634
37 GO:0046631 alpha-beta T cell activation 6.295E-8 5.952E-6 5.200E-5 2.202E-4 9 137
38 GO:0002684 positive regulation of immune system process 6.474E-8 5.960E-6 5.207E-5 2.265E-4 21 980
39 GO:1901698 response to nitrogen compound 6.702E-8 6.011E-6 5.252E-5 2.344E-4 21 982
40 GO:0060537 muscle tissue development 6.878E-8 6.015E-6 5.255E-5 2.406E-4 14 419
41 GO:0051707 response to other organism 7.430E-8 6.188E-6 5.407E-5 2.599E-4 21 988
42 GO:0043207 response to external biotic stimulus 7.430E-8 6.188E-6 5.407E-5 2.599E-4 21 988
43 GO:1902532 negative regulation of intracellular signal transduction 7.864E-8 6.397E-6 5.590E-5 2.751E-4 15 494
44 GO:1903707 negative regulation of hemopoiesis 9.116E-8 7.247E-6 6.332E-5 3.189E-4 9 143
45 GO:0045321 leukocyte activation 1.158E-7 9.001E-6 7.864E-5 4.050E-4 19 833
46 GO:0071417 cellular response to organonitrogen compound 1.454E-7 1.105E-5 9.658E-5 5.085E-4 15 518
47 GO:0002252 immune effector process 1.766E-7 1.314E-5 1.148E-4 6.177E-4 19 856
48 GO:0009991 response to extracellular stimulus 2.912E-7 2.115E-5 1.848E-4 1.019E-3 16 626
49 GO:0014706 striated muscle tissue development 2.964E-7 2.115E-5 1.848E-4 1.037E-3 13 401
50 GO:0060337 type I interferon signaling pathway 3.023E-7 2.115E-5 1.848E-4 1.058E-3 7 81
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 367 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000785 chromatin 1.632E-13 5.989E-11 3.883E-10 5.989E-11 21 489
2 GO:0000790 nuclear chromatin 2.326E-11 4.268E-9 2.767E-8 8.535E-9 16 326
3 GO:0044427 chromosomal part 1.027E-10 1.256E-8 8.143E-8 3.768E-8 23 841
4 GO:0005694 chromosome 9.607E-10 8.814E-8 5.715E-7 3.526E-7 23 943
5 GO:0005667 transcription factor complex 1.401E-9 1.028E-7 6.667E-7 5.141E-7 15 369
6 GO:0044454 nuclear chromosome part 4.036E-9 2.469E-7 1.601E-6 1.481E-6 17 533
7 GO:0000228 nuclear chromosome 1.092E-8 5.728E-7 3.714E-6 4.009E-6 17 570
8 GO:0044451 nucleoplasm part 1.463E-8 6.710E-7 4.351E-6 5.368E-6 19 738
9 GO:0016605 PML body 1.193E-6 4.866E-5 3.155E-4 4.379E-4 7 100
10 GO:0016604 nuclear body 5.082E-6 1.865E-4 1.209E-3 1.865E-3 11 368
11 GO:0005730 nucleolus 2.462E-5 8.214E-4 5.326E-3 9.035E-3 16 894
12 GO:0000775 chromosome, centromeric region 6.716E-5 2.054E-3 1.332E-2 2.465E-2 7 185
13 GO:0000792 heterochromatin 1.169E-4 3.300E-3 2.139E-2 4.289E-2 5 88
14 GO:0048471 perinuclear region of cytoplasm 1.556E-4 4.080E-3 2.645E-2
5.712E-2
 13 728
15 GO:0000118 histone deacetylase complex 3.806E-4 9.313E-3
6.038E-2
1.397E-1
 4 63
16 GO:0005851 eukaryotic translation initiation factor 2B complex 4.310E-4 9.886E-3
6.410E-2
1.582E-1
 2 6
17 GO:0098687 chromosomal region 5.831E-4 1.259E-2
8.162E-2
2.140E-1
 8 345
18 GO:0044798 nuclear transcription factor complex 8.183E-4 1.668E-2
1.082E-1
3.003E-1
 5 134
19 GO:0017053 transcriptional repressor complex 9.419E-4 1.819E-2
1.180E-1
3.457E-1
 4 80
20 GO:0000791 euchromatin 1.324E-3 2.430E-2
1.575E-1
4.860E-1
 3 40
21 GO:0005720 nuclear heterochromatin 1.527E-3 2.668E-2
1.730E-1
5.602E-1
 3 42
22 GO:0071564 npBAF complex 1.857E-3 3.097E-2
2.008E-1
6.813E-1
 2 12
23 GO:0071565 nBAF complex 2.542E-3 3.751E-2
2.432E-1
9.328E-1
 2 14
24 GO:0016580 Sin3 complex 2.542E-3 3.751E-2
2.432E-1
9.328E-1
 2 14
25 GO:0090575 RNA polymerase II transcription factor complex 2.568E-3 3.751E-2
2.432E-1
9.423E-1
 4 105
26 GO:0016363 nuclear matrix 2.657E-3 3.751E-2
2.432E-1
9.752E-1
 4 106
27 GO:0016514 SWI/SNF complex 2.922E-3 3.797E-2
2.462E-1
1.000E0
 2 15
28 GO:0043240 Fanconi anaemia nuclear complex 2.922E-3 3.797E-2
2.462E-1
1.000E0
 2 15
29 GO:0098802 plasma membrane receptor complex 3.000E-3 3.797E-2
2.462E-1
1.000E0
 5 180
30 GO:0070822 Sin3-type complex 3.758E-3 4.598E-2
2.981E-1
1.000E0
 2 17
Show 25 more annotations

4: Human Phenotype [Display Chart] 365 annotations before applied cutoff / 1813 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 2972 annotations before applied cutoff / 9208 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002398 abnormal bone marrow cell morphology/development 3.055E-10 6.134E-7 5.259E-6 9.078E-7 25 567
2 MP:0002123 abnormal definitive hematopoiesis 4.128E-10 6.134E-7 5.259E-6 1.227E-6 32 940
3 MP:0013693 abnormal hemopoiesis 8.285E-10 8.208E-7 7.038E-6 2.462E-6 32 966
4 MP:0008037 abnormal T cell morphology 2.297E-7 1.468E-4 1.259E-3 6.826E-4 28 964
5 MP:0000172 abnormal bone marrow cell number 2.470E-7 1.468E-4 1.259E-3 7.342E-4 13 213
6 MP:0005013 increased lymphocyte cell number 9.207E-7 4.526E-4 3.880E-3 2.736E-3 23 730
7 MP:0002221 abnormal lymph organ size 1.311E-6 4.526E-4 3.880E-3 3.896E-3 27 986
8 MP:0013659 abnormal erythroid lineage cell morphology 1.339E-6 4.526E-4 3.880E-3 3.981E-3 25 864
9 MP:0002401 abnormal lymphopoiesis 1.370E-6 4.526E-4 3.880E-3 4.073E-3 21 634
10 MP:0008866 chromosomal instability 2.069E-6 6.150E-4 5.273E-3 6.150E-3 9 112
11 MP:0010094 abnormal chromosome stability 2.400E-6 6.205E-4 5.320E-3 7.133E-3 9 114
12 MP:0006387 abnormal T cell number 2.505E-6 6.205E-4 5.320E-3 7.446E-3 25 894
13 MP:0002413 abnormal megakaryocyte progenitor cell morphology 3.201E-6 7.317E-4 6.274E-3 9.512E-3 9 118
14 MP:0004939 abnormal B cell morphology 3.564E-6 7.565E-4 6.486E-3 1.059E-2 21 673
15 MP:0000689 abnormal spleen morphology 3.897E-6 7.721E-4 6.621E-3 1.158E-2 26 979
16 MP:0002224 abnormal spleen size 4.788E-6 8.696E-4 7.456E-3 1.423E-2 22 744
17 MP:0005016 decreased lymphocyte cell number 4.974E-6 8.696E-4 7.456E-3 1.478E-2 26 992
18 MP:0005018 decreased T cell number 5.400E-6 8.916E-4 7.645E-3 1.605E-2 21 691
19 MP:0002444 abnormal T cell physiology 8.833E-6 1.352E-3 1.159E-2 2.625E-2 20 655
20 MP:0002144 abnormal B cell differentiation 9.096E-6 1.352E-3 1.159E-2 2.703E-2 14 340
21 MP:0000691 enlarged spleen 1.112E-5 1.574E-3 1.349E-2 3.305E-2 17 498
22 MP:0002417 abnormal megakaryocyte morphology 1.255E-5 1.695E-3 1.454E-2 3.730E-2 8 106
23 MP:0005460 abnormal leukopoiesis 1.346E-5 1.739E-3 1.491E-2 4.000E-2 21 733
24 MP:0000321 increased bone marrow cell number 1.428E-5 1.741E-3 1.492E-2 4.245E-2 6 52
25 MP:0012762 abnormal alpha-beta T cell morphology 1.524E-5 1.741E-3 1.492E-2 4.530E-2 21 739
26 MP:0005091 increased double-positive T cell number 1.598E-5 1.741E-3 1.492E-2 4.748E-2 6 53
27 MP:0002019 abnormal tumor incidence 1.657E-5 1.741E-3 1.492E-2 4.924E-2 22 804
28 MP:0002447 abnormal erythrocyte morphology 1.689E-5 1.741E-3 1.492E-2
5.021E-2
 22 805
29 MP:0002389 abnormal Peyer's patch follicle morphology 1.698E-5 1.741E-3 1.492E-2
5.048E-2
 5 32
30 MP:0013660 abnormal bone marrow hematopoietic cell morphology 1.881E-5 1.864E-3 1.598E-2
5.591E-2
 8 112
31 MP:0002166 altered tumor susceptibility 2.171E-5 2.081E-3 1.785E-2
6.452E-2
 22 818
32 MP:0000350 abnormal cell proliferation 2.336E-5 2.170E-3 1.860E-2
6.943E-2
 24 949
33 MP:0002145 abnormal T cell differentiation 2.514E-5 2.264E-3 1.942E-2
7.472E-2
 15 423
34 MP:0002020 increased tumor incidence 2.824E-5 2.468E-3 2.116E-2
8.392E-2
 20 709
35 MP:0002391 abnormal Peyer's patch germinal center morphology 3.660E-5 3.028E-3 2.596E-2
1.088E-1
 4 19
36 MP:0002458 abnormal B cell number 3.722E-5 3.028E-3 2.596E-2
1.106E-1
 18 604
37 MP:0012765 decreased alpha-beta T cell number 3.770E-5 3.028E-3 2.596E-2
1.120E-1
 14 386
38 MP:0008171 abnormal mature B cell morphology 3.974E-5 3.108E-3 2.665E-2
1.181E-1
 18 607
39 MP:0008195 abnormal professional antigen presenting cell morphology 4.528E-5 3.451E-3 2.959E-2
1.346E-1
 24 988
40 MP:0011704 decreased fibroblast proliferation 4.674E-5 3.472E-3 2.977E-2
1.389E-1
 8 127
41 MP:0009332 abnormal splenocyte morphology 5.677E-5 4.041E-3 3.465E-2
1.687E-1
 6 66
42 MP:0013152 abnormal organ/body region tumor incidence 5.711E-5 4.041E-3 3.465E-2
1.697E-1
 18 624
43 MP:0002459 abnormal B cell physiology 6.603E-5 4.564E-3 3.913E-2
1.962E-1
 18 631
44 MP:0002435 abnormal effector T cell morphology 7.403E-5 4.899E-3 4.200E-2
2.200E-1
 19 697
45 MP:0002452 abnormal professional antigen presenting cell physiology 7.418E-5 4.899E-3 4.200E-2
2.204E-1
 23 952
46 MP:0004028 chromosome breakage 7.926E-5 5.029E-3 4.312E-2
2.355E-1
 6 70
47 MP:0001793 altered susceptibility to infection 8.053E-5 5.029E-3 4.312E-2
2.393E-1
 16 524
48 MP:0012763 abnormal alpha-beta T cell number 8.123E-5 5.029E-3 4.312E-2
2.414E-1
 17 582
49 MP:0006410 abnormal common myeloid progenitor cell morphology 8.872E-5 5.352E-3 4.589E-2
2.637E-1
 8 139
50 MP:0002006 neoplasm 9.003E-5 5.352E-3 4.589E-2
2.676E-1
 22 898
Show 45 more annotations

6: Domain [Display Chart] 693 annotations before applied cutoff / 16924 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00036 BZIP BASIC PROSITE 5.631E-7 1.095E-4 7.795E-4 3.903E-4 6 52
2 SM00338 BRLZ SMART 5.631E-7 1.095E-4 7.795E-4 3.903E-4 6 52
3 IPR004827 TF bZIP InterPro 6.320E-7 1.095E-4 7.795E-4 4.380E-4 6 53
4 PS50217 BZIP PROSITE 6.320E-7 1.095E-4 7.795E-4 4.380E-4 6 53
5 IPR008917 Euk TF DNA-bd InterPro 2.325E-6 3.222E-4 2.294E-3 1.611E-3 5 37
6 PF00010 HLH Pfam 3.256E-6 3.302E-4 2.351E-3 2.256E-3 7 108
7 PS50888 HLH PROSITE 4.403E-6 3.302E-4 2.351E-3 3.052E-3 7 113
8 G3DSA:4.10.280.10 HLH DNA bd Gene3D 4.403E-6 3.302E-4 2.351E-3 3.052E-3 7 113
9 SM00353 HLH SMART 4.669E-6 3.302E-4 2.351E-3 3.236E-3 7 114
10 IPR011598 HLH DNA-bd InterPro 4.948E-6 3.302E-4 2.351E-3 3.429E-3 7 115
11 IPR001092 HLH DNA-bd dom InterPro 5.241E-6 3.302E-4 2.351E-3 3.632E-3 7 116
12 PF00170 bZIP 1 Pfam 4.465E-5 2.380E-3 1.694E-2 3.094E-2 4 34
13 IPR011616 bZIP 1 InterPro 4.465E-5 2.380E-3 1.694E-2 3.094E-2 4 34
14 PF11928 DUF3446 Pfam 1.012E-4 3.693E-3 2.629E-2
7.016E-2
 2 3
15 IPR016374 TF GATA-1/2/3 InterPro 1.012E-4 3.693E-3 2.629E-2
7.016E-2
 2 3
16 IPR021849 DUF3446 InterPro 1.012E-4 3.693E-3 2.629E-2
7.016E-2
 2 3
17 IPR000812 TFIIB-related InterPro 1.012E-4 3.693E-3 2.629E-2
7.016E-2
 2 3
18 PS00782 TFIIB PROSITE 1.012E-4 3.693E-3 2.629E-2
7.016E-2
 2 3
19 PS51134 ZF TFIIB PROSITE 1.012E-4 3.693E-3 2.629E-2
7.016E-2
 2 3
20 IPR013137 Znf TFIIB InterPro 2.017E-4 6.656E-3 4.738E-2
1.398E-1
 2 4
21 PF08271 TFIIB Zn Ribbon Pfam 2.017E-4 6.656E-3 4.738E-2
1.398E-1
 2 4
22 PF08725 Integrin b cyt Pfam 5.004E-4 1.240E-2
8.828E-2
3.468E-1
 2 6
23 G3DSA:1.20.5.630 Integrin bsu cyt Gene3D 5.004E-4 1.240E-2
8.828E-2
3.468E-1
 2 6
24 IPR014836 Integrin bsu cyt InterPro 5.004E-4 1.240E-2
8.828E-2
3.468E-1
 2 6
25 IPR012896 Integrin bsu tail InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
26 IPR012012 Integrin bsu subgr InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
27 SM00964 STAT int SMART 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
28 G3DSA:1.20.1050.20 STAT alpha Gene3D 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
29 PF02865 STAT int Pfam 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
30 IPR013799 STAT TF prot interaction InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
31 IPR013801 STAT TF DNA-bd InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
32 PF07965 Integrin B tail Pfam 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
33 IPR001217 STAT TF core InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
34 IPR012345 STAT TF DNA-bd sub InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
35 PF02864 STAT bind Pfam 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
36 G3DSA:1.10.532.10 STAT protein interaction Gene3D 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
37 PF01017 STAT alpha Pfam 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
38 G3DSA:2.60.40.630 STAT DNA bd sub Gene3D 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
39 IPR015988 STAT TF coiled-coil InterPro 6.979E-4 1.240E-2
8.828E-2
4.836E-1
 2 7
40 PF00362 Integrin beta Pfam 9.270E-4 1.494E-2
1.064E-1
6.424E-1
 2 8
41 SM00187 INB SMART 9.270E-4 1.494E-2
1.064E-1
6.424E-1
 2 8
42 IPR013800 STAT TF alpha InterPro 9.270E-4 1.494E-2
1.064E-1
6.424E-1
 2 8
43 IPR002369 Integrin bsu N InterPro 9.270E-4 1.494E-2
1.064E-1
6.424E-1
 2 8
44 IPR019817 Interferon reg fac CS InterPro 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
45 IPR001169 Integrin bsu C InterPro 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
46 PS51507 IRF 2 PROSITE 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
47 PS00243 INTEGRIN BETA PROSITE 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
48 IPR015812 Integrin bsu InterPro 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
49 SM00348 IRF SMART 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
50 PS00601 IRF 1 PROSITE 1.187E-3 1.582E-2
1.126E-1
8.228E-1
 2 9
Show 45 more annotations

7: Pathway [Display Chart] 889 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 523016 Transcriptional misregulation in cancer BioSystems: KEGG 1.391E-8 1.237E-5 9.111E-5 1.237E-5 12 179
2 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 1.596E-7 7.096E-5 5.228E-4 1.419E-4 8 78
3 M19336 Type I Interferon (alpha/beta IFN) Pathway MSigDB C2 BIOCARTA (v5.1) 4.391E-7 1.165E-4 8.586E-4 3.903E-4 4 9
4 138040 IFN-gamma pathway BioSystems: Pathway Interaction Database 6.208E-7 1.165E-4 8.586E-4 5.519E-4 6 40
5 755437 Type III interferon signaling BioSystems: WikiPathways 7.274E-7 1.165E-4 8.586E-4 6.467E-4 4 10
6 187104 Interferon alpha/beta signaling BioSystems: REACTOME 7.865E-7 1.165E-4 8.586E-4 6.992E-4 7 66
7 137932 IL6-mediated signaling events BioSystems: Pathway Interaction Database 9.675E-7 1.229E-4 9.053E-4 8.601E-4 6 43
8 198782 EGFR1 Signaling Pathway BioSystems: WikiPathways 1.190E-6 1.322E-4 9.744E-4 1.058E-3 10 177
9 137929 IL27-mediated signaling events BioSystems: Pathway Interaction Database 1.559E-6 1.540E-4 1.134E-3 1.386E-3 5 26
10 198918 Type II interferon signaling (IFNG) BioSystems: WikiPathways 2.413E-6 2.145E-4 1.581E-3 2.145E-3 6 50
11 138014 Glucocorticoid receptor regulatory network BioSystems: Pathway Interaction Database 3.469E-6 2.803E-4 2.065E-3 3.084E-3 7 82
12 920977 RB in Cancer BioSystems: WikiPathways 5.165E-6 3.826E-4 2.819E-3 4.592E-3 7 87
13 373901 HTLV-I infection BioSystems: KEGG 6.370E-6 4.356E-4 3.210E-3 5.663E-3 11 263
14 138012 Signaling mediated by p38-alpha and p38-beta BioSystems: Pathway Interaction Database 7.275E-6 4.620E-4 3.404E-3 6.467E-3 5 35
15 187103 Interferon Signaling BioSystems: REACTOME 8.270E-6 4.901E-4 3.611E-3 7.352E-3 9 173
16 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 1.248E-5 6.726E-4 4.956E-3 1.109E-2 6 66
17 187196 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 1.299E-5 6.726E-4 4.956E-3 1.155E-2 8 139
18 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 1.362E-5 6.726E-4 4.956E-3 1.211E-2 6 67
19 377873 Herpes simplex infection BioSystems: KEGG 1.616E-5 7.559E-4 5.570E-3 1.436E-2 9 188
20 694606 Hepatitis B BioSystems: KEGG 1.859E-5 8.069E-4 5.945E-3 1.653E-2 8 146
21 187106 Interferon gamma signaling BioSystems: REACTOME 1.906E-5 8.069E-4 5.945E-3 1.694E-2 6 71
22 M2579 Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. MSigDB C2 BIOCARTA (v5.1) 2.574E-5 1.010E-3 7.442E-3 2.288E-2 5 45
23 672462 Prolactin Signaling Pathway BioSystems: WikiPathways 2.613E-5 1.010E-3 7.442E-3 2.323E-2 6 75
24 585562 Epstein-Barr virus infection BioSystems: KEGG 2.972E-5 1.067E-3 7.865E-3 2.642E-2 9 203
25 83077 Jak-STAT signaling pathway BioSystems: KEGG 3.002E-5 1.067E-3 7.865E-3 2.669E-2 8 156
26 138073 C-MYB transcription factor network BioSystems: Pathway Interaction Database 3.271E-5 1.099E-3 8.094E-3 2.908E-2 6 78
27 658418 Viral carcinogenesis BioSystems: KEGG 3.336E-5 1.099E-3 8.094E-3 2.966E-2 9 206
28 137993 Calcineurin-regulated NFAT-dependent transcription in lymphocytes BioSystems: Pathway Interaction Database 3.541E-5 1.124E-3 8.283E-3 3.148E-2 5 48
29 169351 Validated targets of C-MYC transcriptional activation BioSystems: Pathway Interaction Database 4.056E-5 1.243E-3 9.162E-3 3.606E-2 6 81
30 138027 Regulation of Androgen receptor activity BioSystems: Pathway Interaction Database 4.328E-5 1.282E-3 9.449E-3 3.847E-2 5 50
31 PW:0000209 JAK-STAT signaling Pathway Ontology 7.339E-5 2.086E-3 1.537E-2
6.524E-2
 4 29
32 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 7.518E-5 2.086E-3 1.537E-2
6.684E-2
 5 56
33 193147 Osteoclast differentiation BioSystems: KEGG 7.832E-5 2.086E-3 1.537E-2
6.962E-2
 7 132
34 217173 Influenza A BioSystems: KEGG 7.978E-5 2.086E-3 1.537E-2
7.093E-2
 8 179
35 198832 Adipogenesis BioSystems: WikiPathways 8.215E-5 2.087E-3 1.537E-2
7.303E-2
 7 133
36 137939 Direct p53 effectors BioSystems: Pathway Interaction Database 8.613E-5 2.127E-3 1.567E-2
7.657E-2
 7 134
37 M1909 EGF Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 9.606E-5 2.308E-3 1.701E-2
8.540E-2
 4 31
38 M2529 PDGF Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 1.091E-4 2.553E-3 1.881E-2
9.701E-2
 4 32
39 169353 Validated targets of C-MYC transcriptional repression BioSystems: Pathway Interaction Database 1.227E-4 2.798E-3 2.061E-2
1.091E-1
 5 62
40 137933 IL4-mediated signaling events BioSystems: Pathway Interaction Database 1.325E-4 2.945E-3 2.170E-2
1.178E-1
 5 63
41 138057 ErbB1 downstream signaling BioSystems: Pathway Interaction Database 1.557E-4 3.375E-3 2.487E-2
1.384E-1
 6 103
42 169350 Signaling events mediated by TCPTP BioSystems: Pathway Interaction Database 1.745E-4 3.694E-3 2.722E-2
1.551E-1
 4 36
43 137965 a4b1 and a4b7 Integrin signaling BioSystems: Pathway Interaction Database 1.831E-4 3.786E-3 2.789E-2
1.628E-1
 2 3
44 219801 Integrated Breast Cancer Pathway BioSystems: WikiPathways 2.052E-4 4.146E-3 3.055E-2
1.824E-1
 7 154
45 83105 Pathways in cancer BioSystems: KEGG 2.383E-4 4.708E-3 3.469E-2
2.119E-1
 10 327
46 M8066 IL22 Soluble Receptor Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 2.455E-4 4.745E-3 3.496E-2
2.183E-1
 3 16
47 198901 SIDS Susceptibility Pathways BioSystems: WikiPathways 2.595E-4 4.909E-3 3.617E-2
2.307E-1
 7 160
48 M6778 IL-10 Anti-inflammatory Signaling Pathway MSigDB C2 BIOCARTA (v5.1) 2.964E-4 5.490E-3 4.045E-2
2.635E-1
 3 17
49 198885 IL-2 Signaling pathway BioSystems: WikiPathways 3.199E-4 5.804E-3 4.276E-2
2.844E-1
 4 42
50 137912 Hedgehog signaling events mediated by Gli proteins BioSystems: Pathway Interaction Database 3.506E-4 6.165E-3 4.543E-2
3.117E-1
 4 43
Show 45 more annotations

8: Pubmed [Display Chart] 29565 annotations before applied cutoff / 51818 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 25609649 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Pubmed 6.858E-21 2.028E-16 2.204E-15 2.028E-16 24 849
2 11438660 A conserved alpha-helical motif mediates the interaction of Sp1-like transcriptional repressors with the corepressor mSin3A. Pubmed 1.575E-15 2.329E-11 2.532E-10 4.658E-11 6 8
3 18950845 Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. Pubmed 2.063E-13 2.033E-9 2.210E-8 6.099E-9 9 89
4 20936779 A human MAP kinase interactome. Pubmed 1.247E-12 9.216E-9 1.002E-7 3.686E-8 14 486
5 18950845:gr Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study. GeneRIF 1.126E-11 6.659E-8 7.239E-7 3.330E-7 8 88
6 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 1.455E-11 7.168E-8 7.792E-7 4.301E-7 12 371
7 24952347 DNMT3L interacts with transcription factors to target DNMT3L/DNMT3B to specific DNA sequences: role of the DNMT3L/DNMT3B/p65-NF¿B complex in the (de-)methylation of TRAF1. Pubmed 1.722E-10 7.271E-7 7.905E-6 5.090E-6 7 74
8 14559996 mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad. Pubmed 2.479E-10 9.163E-7 9.962E-6 7.331E-6 5 18
9 9184233 Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. Pubmed 5.333E-10 1.642E-6 1.785E-5 1.577E-5 4 7
10 15302935 Large-scale characterization of HeLa cell nuclear phosphoproteins. Pubmed 5.553E-10 1.642E-6 1.785E-5 1.642E-5 14 773
11 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 1.039E-9 2.422E-6 2.633E-5 3.072E-5 11 422
12 19692168:gr Genetic susceptibility to distinct bladder cancer subphenotypes. GeneRIF 1.039E-9 2.422E-6 2.633E-5 3.072E-5 11 422
13 16878156 Cooperation between Myc and YY1 provides novel silencing transcriptional targets of alpha3beta1-integrin in tumour cells. Pubmed 1.065E-9 2.422E-6 2.633E-5 3.149E-5 4 8
14 9819382 TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3. Pubmed 3.185E-9 5.539E-6 6.022E-5 9.417E-5 4 10
15 20980339:gr Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway. GeneRIF 3.185E-9 5.539E-6 6.022E-5 9.417E-5 4 10
16 20980339 Hepatitis B viraemia: its heritability and association with common genetic variation in the interferon gamma signalling pathway. Pubmed 3.185E-9 5.539E-6 6.022E-5 9.417E-5 4 10
17 11238380 Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes. Pubmed 3.185E-9 5.539E-6 6.022E-5 9.417E-5 4 10
18 20398657 The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor. Pubmed 4.816E-9 6.462E-6 7.025E-5 1.424E-4 5 31
19 17923090 Acetylation-dependent signal transduction for type I interferon receptor. Pubmed 4.997E-9 6.462E-6 7.025E-5 1.477E-4 4 11
20 19625176:gr PTEN identified as important risk factor of chronic obstructive pulmonary disease. GeneRIF 5.118E-9 6.462E-6 7.025E-5 1.513E-4 10 376
21 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 5.118E-9 6.462E-6 7.025E-5 1.513E-4 10 376
22 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 5.802E-9 6.462E-6 7.025E-5 1.715E-4 10 381
23 18676680:gr Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. GeneRIF 5.802E-9 6.462E-6 7.025E-5 1.715E-4 10 381
24 19170196:gr Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. GeneRIF 6.098E-9 6.462E-6 7.025E-5 1.803E-4 10 383
25 19453261 High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Pubmed 6.098E-9 6.462E-6 7.025E-5 1.803E-4 10 383
26 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 6.098E-9 6.462E-6 7.025E-5 1.803E-4 10 383
27 19453261:gr High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. GeneRIF 6.098E-9 6.462E-6 7.025E-5 1.803E-4 10 383
28 10702714 Viral inhibition of interferon signal transduction. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
29 11804954 Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
30 17351669 STAT activation and differential complex formation dictate selectivity of interferon responses. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
31 22496215:gr Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. GeneRIF 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
32 8078932 The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
33 8943351 Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
34 11804954:gr Roles of Stat1, Stat2, and interferon regulatory factor-9 (IRF-9) in interferon tau regulation of IRF-1. GeneRIF 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
35 12036432 Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
36 24065129 IFNß-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage. Pubmed 7.869E-9 6.462E-6 7.025E-5 2.326E-4 3 3
37 20503287:gr Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. GeneRIF 9.370E-9 7.195E-6 7.822E-5 2.770E-4 8 204
38 20503287 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Pubmed 9.370E-9 7.195E-6 7.822E-5 2.770E-4 8 204
39 19258923 Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pubmed 9.734E-9 7.195E-6 7.822E-5 2.878E-4 8 205
40 19258923:gr Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. GeneRIF 9.734E-9 7.195E-6 7.822E-5 2.878E-4 8 205
41 17703412 Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Pubmed 1.050E-8 7.391E-6 8.035E-5 3.104E-4 8 207
42 17703412:gr Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. GeneRIF 1.050E-8 7.391E-6 8.035E-5 3.104E-4 8 207
43 10319872 c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function. Pubmed 3.137E-8 1.973E-5 2.145E-4 9.274E-4 3 4
44 12824180 Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. Pubmed 3.137E-8 1.973E-5 2.145E-4 9.274E-4 3 4
45 26397446 Interferon-stimulated gene factor 3 complex is required for the induction of sterile ¿ motif and HD domain-containing protein 1 expression by interferon-¿ in SMMC-7721 cells. Pubmed 3.137E-8 1.973E-5 2.145E-4 9.274E-4 3 4
46 20403236 [A novel molecular mechanism of interferon alpha-regulated expression of retinoic acid-induced gene G]. Pubmed 3.137E-8 1.973E-5 2.145E-4 9.274E-4 3 4
47 20403236:gr [A novel molecular mechanism of interferon alpha-regulated expression of retinoic acid-induced gene G]. GeneRIF 3.137E-8 1.973E-5 2.145E-4 9.274E-4 3 4
48 22242598 Human CCAAT/enhancer-binding protein ß interacts with chromatin remodeling complexes of the imitation switch subfamily. Pubmed 4.724E-8 2.910E-5 3.163E-4 1.397E-3 5 48
49 19730683:gr The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. GeneRIF 5.440E-8 3.217E-5 3.497E-4 1.608E-3 6 99
50 19730683 The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. Pubmed 5.440E-8 3.217E-5 3.497E-4 1.608E-3 6 99
Show 45 more annotations

9: Interaction [Display Chart] 3704 annotations before applied cutoff / 16535 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:EP300 EP300 interactions 3.038E-19 7.277E-16 6.400E-15 1.125E-15 28 501
2 int:CREBBP CREBBP interactions 3.929E-19 7.277E-16 6.400E-15 1.455E-15 25 371
3 int:HDAC1 HDAC1 interactions 3.723E-18 4.596E-15 4.042E-14 1.379E-14 28 551
4 int:SPI1 SPI1 interactions 1.749E-15 1.619E-12 1.424E-11 6.477E-12 12 59
5 int:JUN JUN interactions 3.638E-15 2.695E-12 2.370E-11 1.347E-11 19 265
6 int:SIN3A SIN3A interactions 3.677E-14 2.014E-11 1.771E-10 1.362E-10 17 221
7 int:SP1 SP1 interactions 3.806E-14 2.014E-11 1.771E-10 1.410E-10 18 260
8 int:RELA RELA interactions 8.925E-14 4.132E-11 3.634E-10 3.306E-10 19 316
9 int:SMARCA4 SMARCA4 interactions 3.981E-12 1.638E-9 1.441E-8 1.474E-8 16 251
10 int:PML PML interactions 1.938E-11 6.661E-9 5.858E-8 7.180E-8 15 235
11 int:KAT2B KAT2B interactions 1.978E-11 6.661E-9 5.858E-8 7.327E-8 14 195
12 int:TBP TBP interactions 1.239E-10 3.826E-8 3.365E-7 4.591E-7 13 183
13 int:MAF MAF interactions 1.390E-10 3.960E-8 3.483E-7 5.149E-7 7 25
14 int:HDAC2 HDAC2 interactions 3.549E-10 9.390E-8 8.258E-7 1.315E-6 16 339
15 int:SMARCA5 SMARCA5 interactions 6.541E-10 1.562E-7 1.374E-6 2.423E-6 11 132
16 int:RUNX1 RUNX1 interactions 6.747E-10 1.562E-7 1.374E-6 2.499E-6 10 100
17 int:NCOR1 NCOR1 interactions 8.803E-10 1.865E-7 1.640E-6 3.261E-6 12 173
18 int:CSNK2A1 CSNK2A1 interactions 9.062E-10 1.865E-7 1.640E-6 3.357E-6 18 476
19 int:BRCA1 BRCA1 interactions 1.097E-9 2.066E-7 1.817E-6 4.065E-6 19 544
20 int:TAL1 TAL1 interactions 1.116E-9 2.066E-7 1.817E-6 4.133E-6 8 52
21 int:HDAC3 HDAC3 interactions 1.507E-9 2.658E-7 2.338E-6 5.582E-6 13 224
22 int:STAT3 STAT3 interactions 1.614E-9 2.717E-7 2.389E-6 5.977E-6 14 272
23 int:STAT1 STAT1 interactions 2.573E-9 4.144E-7 3.644E-6 9.530E-6 12 190
24 int:CREB1 CREB1 interactions 3.881E-9 5.990E-7 5.268E-6 1.437E-5 11 156
25 int:SMARCA2 SMARCA2 interactions 4.078E-9 6.042E-7 5.314E-6 1.510E-5 10 120
26 int:RB1 RB1 interactions 6.584E-9 9.379E-7 8.249E-6 2.439E-5 13 253
27 int:SIN3B SIN3B interactions 6.997E-9 9.598E-7 8.441E-6 2.592E-5 8 65
28 int:CEBPA CEBPA interactions 8.418E-9 1.114E-6 9.793E-6 3.118E-5 12 211
29 int:MECP2 MECP2 interactions 8.948E-9 1.143E-6 1.005E-5 3.314E-5 8 67
30 int:SP3 SP3 interactions 1.184E-8 1.462E-6 1.286E-5 4.385E-5 7 45
31 int:BCL3 BCL3 interactions 1.624E-8 1.940E-6 1.706E-5 6.015E-5 7 47
32 int:NR5A1 NR5A1 interactions 1.891E-8 2.189E-6 1.925E-5 7.006E-5 7 48
33 int:NFATC1 NFATC1 interactions 3.364E-8 3.776E-6 3.320E-5 1.246E-4 8 79
34 int:IRF9 IRF9 interactions 3.469E-8 3.779E-6 3.323E-5 1.285E-4 6 31
35 int:ESR1 ESR1 interactions 4.405E-8 4.662E-6 4.100E-5 1.632E-4 20 758
36 int:FOSL1 FOSL1 interactions 5.165E-8 5.314E-6 4.674E-5 1.913E-4 6 33
37 int:SMARCB1 SMARCB1 interactions 5.912E-8 5.918E-6 5.205E-5 2.190E-4 9 119
38 int:IFNAR2 IFNAR2 interactions 7.173E-8 6.991E-6 6.149E-5 2.657E-4 5 18
39 int:TAF6 TAF6 interactions 1.316E-7 1.200E-5 1.055E-4 4.874E-4 7 63
40 int:HDAC9 HDAC9 interactions 1.316E-7 1.200E-5 1.055E-4 4.874E-4 7 63
41 int:CEBPB CEBPB interactions 1.328E-7 1.200E-5 1.055E-4 4.919E-4 8 94
42 int:MAFK MAFK interactions 2.747E-7 2.423E-5 2.131E-4 1.018E-3 5 23
43 int:MXI1 MXI1 interactions 3.453E-7 2.975E-5 2.616E-4 1.279E-3 5 24
44 int:CDK8 CDK8 interactions 4.195E-7 3.522E-5 3.098E-4 1.554E-3 8 109
45 int:POLR2A POLR2A interactions 4.279E-7 3.522E-5 3.098E-4 1.585E-3 12 302
46 int:MAPK1 MAPK1 interactions 4.923E-7 3.964E-5 3.486E-4 1.823E-3 12 306
47 int:SATB1 SATB1 interactions 6.012E-7 4.738E-5 4.167E-4 2.227E-3 6 49
48 int:GABPB1 GABPB1 interactions 7.827E-7 6.040E-5 5.311E-4 2.899E-3 5 28
49 int:JUNB JUNB interactions 8.620E-7 6.516E-5 5.730E-4 3.193E-3 6 52
50 int:EGR1 EGR1 interactions 9.671E-7 7.164E-5 6.300E-4 3.582E-3 6 53
Show 45 more annotations

10: Cytoband [Display Chart] 94 annotations before applied cutoff / 34661 genes in category

No results to display

11: Transcription Factor Binding Site [Display Chart] 534 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 15 annotations before applied cutoff / 6751 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 KLF Kruppel-like factors genenames.org 3.381E-9 5.072E-8 1.683E-7 5.072E-8 5 17
2 CD CD molecules genenames.org 5.096E-4 2.880E-3 9.556E-3 7.644E-3 6 276
3 ZBTB Zinc fingers, C2H2 and BTB domain containing genenames.org 7.350E-4 2.880E-3 9.556E-3 1.102E-2 3 47
4 FANC Fanconi anemia, complementation groups genenames.org 7.680E-4 2.880E-3 9.556E-3 1.152E-2 2 11
5 ZRANB Zinc fingers, RAN binding-type genenames.org 1.911E-2 4.906E-2
1.628E-1
2.867E-1
 1 5
6 MXD MAX dimerization proteins genenames.org 2.289E-2 4.906E-2
1.628E-1
3.434E-1
 1 6
7 SMC Structural maintenance of chromosomes proteins genenames.org 2.289E-2 4.906E-2
1.628E-1
3.434E-1
 1 6
Show 2 more annotations

13: Coexpression [Display Chart] 5877 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v5.1) 3.609E-14 2.121E-10 1.963E-9 2.121E-10 15 200
2 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.277E-10 1.257E-6 1.163E-5 2.514E-6 14 323
3 M16311 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with EGF [GeneID=1950]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.105E-8 2.162E-5 2.002E-4 6.497E-5 7 58
4 M1417 Genes down-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]). MSigDB C2: CGP Curated Gene Sets (v5.1) 2.776E-8 2.162E-5 2.002E-4 1.631E-4 7 66
5 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.795E-8 2.162E-5 2.002E-4 1.642E-4 8 101
6 GSE41978 ID2 KO VS BIM KO KLRG1 LOW EFFECTOR CD8 TCELL UP Genes up-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 [GeneID=10219] knockout versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.860E-8 2.162E-5 2.002E-4 2.269E-4 10 199
7 GSE37533 PPARG1 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 4.047E-8 2.162E-5 2.002E-4 2.379E-4 10 200
8 M3497 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 40 min. MSigDB C7: Immunologic Signatures (v5.1) 4.047E-8 2.162E-5 2.002E-4 2.379E-4 10 200
9 GSE42021 TREG VS TCONV PLN UP Genes up-regulated in cells from peripheral lymph nodes: T reg versus T conv. MSigDB C7: Immunologic Signatures (v5.1) 4.047E-8 2.162E-5 2.002E-4 2.379E-4 10 200
10 M3504 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 120 min. MSigDB C7: Immunologic Signatures (v5.1) 4.047E-8 2.162E-5 2.002E-4 2.379E-4 10 200
11 GSE37533 PPARG1 FOXP3 VS PPARG2 FOXP3 TRANSDUCED CD4 TCELL PIOGLITAZONE TREATED DN Genes down-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v5.1) 4.047E-8 2.162E-5 2.002E-4 2.379E-4 10 200
12 M17211 Transcription factors down-regulated in LNCaP cells (prostate cancer) by expression of GR [GeneID=2908] off a lentiviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.918E-8 4.857E-5 4.496E-4 5.829E-4 4 10
13 M12391 Top 50 genes up-regulated in A549 cells (lung cancer) expressing STAT3 [GeneID=6774] off an adenovirus vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.185E-7 5.358E-5 4.959E-4 6.965E-4 6 49
14 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.569E-7 6.585E-5 6.095E-4 9.219E-4 9 175
15 M1869 Genes up-regulated in bone marrow progenitors by constitutively active NOTCH1 [GeneID=4851]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.706E-7 6.683E-5 6.186E-4 1.002E-3 6 52
16 M5897 Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. MSigDB H: Hallmark Gene Sets (v5.1) 1.919E-7 6.893E-5 6.380E-4 1.128E-3 7 87
17 GSE26488 CTRL VS PEPTIDE INJECTION OT2 THYMOCYTE DN Genes down-regulated in double positive thymocytes from OT-2 transgenic mice: control versus injected with agonist peptide. MSigDB C7: Immunologic Signatures (v5.1) 1.994E-7 6.893E-5 6.380E-4 1.172E-3 9 180
18 M6782 Genes up-regulated in T24 (bladder cancer) cells in response to the photodynamic therapy (PDT) stress. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.687E-7 8.773E-5 8.121E-4 1.579E-3 17 811
19 M6150 Genes down-regulated in monocyte-derived macrophages: untreated versus stimulated by interferon alpha. MSigDB C7: Immunologic Signatures (v5.1) 3.599E-7 1.013E-4 9.378E-4 2.115E-3 9 193
20 M8244 Genes changed in INA-6 cells (multiple myeloma, MM) by re-addition of IL6 [GeneID=3569] after its initial withdrawal for 12h. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.398E-7 1.013E-4 9.378E-4 2.584E-3 8 144
21 M3022 Genes down-regulated in comparison of naive versus effector CD8 T cells at contraction (day 15 after LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
22 GSE22140 GERMFREE VS SPF MOUSE CD4 TCELL UP Genes up-regulated in healthy CD4 [GeneID=920] T cells: germ free versus specific pathogen free. MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
23 GSE32164 RESTING DIFFERENTIATED VS ALTERNATIVELY ACT M2 MACROPHAGE DN Genes down-regulated in macrophages: resting differentiated versus alternatively activated M2. MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
24 M5832 Genes down-regulated in comparison of naive CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
25 M3502 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 80 min. MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
26 GSE37533 PPARG2 FOXP3 VS FOXP3 TRANSDUCED CD4 TCELL DN Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
27 M3499 Genes down-regulated in comparison of unstimulated macrophage cells versus macrophage cells stimulated with LPS (TLR4 agonist) for 60 min. MSigDB C7: Immunologic Signatures (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
28 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v5.1) 4.857E-7 1.013E-4 9.378E-4 2.855E-3 9 200
29 M14079 Breast cancer compendium: 100 transcription regulators showing most correlated expression with the 9 'embryonic stem cell' transcription factors that are preferentially and coordinately overexpressed in the high-grade, ER-negative breast cancer tumors. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.999E-7 1.013E-4 9.378E-4 2.938E-3 7 100
30 M8144 Genes up-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.201E-7 1.019E-4 9.431E-4 3.057E-3 18 952
31 M13941 Clusters 1 and 2: genes up-regulated in B2264-19/3 cells (primary B lymphocytes) within 30-60 min after activation of LMP1 (an oncogene encoded by Epstein-Barr virus, EBV). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.214E-7 1.368E-4 1.266E-3 4.240E-3 6 66
32 M17915 Genes up-regulated in HL-60 cells (acute promyelocytic leukemia, APL) after treatment with the aminopeptidase inhibitor tosedostat (CHR-2797) [PubChem=15547703] for 24 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.643E-7 1.587E-4 1.469E-3 5.080E-3 16 782
33 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v5.1) 1.026E-6 1.828E-4 1.692E-3 6.032E-3 8 161
34 M2858 Genes up-regulated in NOMO-1 and SKM-1 cells (AML) after knockdown of STK33 [Gene ID=65975] by RNAi. MSigDB C6: Oncogenic Signatures (v5.1) 1.179E-6 2.022E-4 1.871E-3 6.929E-3 10 288
35 M7928 Genes up-regulated in the MM1S cells (multiple myeloma) after treatment with aplidin [PubChem=44152164], a marine-derived compound with potential anti-cancer properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.204E-6 2.022E-4 1.871E-3 7.075E-3 12 439
36 M11516 Selected genes changed in K562 (immortalized erythroleukemia) cells induced by hemin [PubChem=26945] treatment to express erythroid properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.316E-6 2.148E-4 1.988E-3 7.732E-3 6 73
37 M6818 Genes down-regulated in dendritic cells: untreated versus anti-FcgRIIB. MSigDB C7: Immunologic Signatures (v5.1) 1.615E-6 2.566E-4 2.375E-3 9.494E-3 8 171
38 M4389 Selected genes down-regulated in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts) at 12 h time point. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.842E-6 2.848E-4 2.636E-3 1.082E-2 5 43
39 M15031 Genes up-regulated in MCF10A cells (breast cancer) by expression of LSM1 [GeneID=27257] off a letiviral vector. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.070E-6 3.119E-4 2.887E-3 1.216E-2 5 44
40 GSE37605 FOXP3 FUSION GFP VS IRES GFP TREG C57BL6 UP Genes up-regulated in T reg (FOXP3+ [GeneID=50943]) cells from B6 mice: Foxp3-Fusion-GFP versus Foxp3-ires-GFP. MSigDB C7: Immunologic Signatures (v5.1) 2.574E-6 3.782E-4 3.501E-3 1.513E-2 8 182
41 M13183 Genes down-regulated in P493-6 cells (B lymphocyte, Burkitt's lymphoma model) by MYC [GeneID=4609] and up-regulated by RNAi knockdown of TFRC [GeneID=7037]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.807E-6 4.024E-4 3.725E-3 1.650E-2 6 83
42 M14666 Genes modulated in HeLa cells (cervical carcinoma) by TNF [GeneID=7124] not via NFKB pathway. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.306E-6 4.626E-4 4.282E-3 1.943E-2 4 22
43 GSE40685 TREG VS FOXP3 KO TREG PRECURSOR UP Genes up-regulated in CD4: FOXP3+ [GeneID=50943] T reg versus FOXP3 [GeneID=50943] knockout T reg precursor. MSigDB C7: Immunologic Signatures (v5.1) 4.294E-6 5.070E-4 4.693E-3 2.524E-2 8 195
44 M2504 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were not affected by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.792E-6 5.070E-4 4.693E-3 2.816E-2 10 337
45 M3186 Genes down-regulated in comparison of IgD+ peripheral blood B cells versus IgD- naive tonsil B cells. MSigDB C7: Immunologic Signatures (v5.1) 4.988E-6 5.070E-4 4.693E-3 2.932E-2 8 199
46 GSE17186 NAIVE VS CD21LOW TRANSITIONAL BCELL UP Genes up-regulated in B lymphocytes: naïve versus transitional CR2 [GeneID=1380] low. MSigDB C7: Immunologic Signatures (v5.1) 5.176E-6 5.070E-4 4.693E-3 3.042E-2 8 200
47 M3454 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus T cells from cord blood. MSigDB C7: Immunologic Signatures (v5.1) 5.176E-6 5.070E-4 4.693E-3 3.042E-2 8 200
48 GSE21360 PRIMARY VS TERTIARY MEMORY CD8 TCELL DN Genes down-regulated in memory CD8 T cells: 1' versus 3'. MSigDB C7: Immunologic Signatures (v5.1) 5.176E-6 5.070E-4 4.693E-3 3.042E-2 8 200
49 M5526 Genes up-regulated in comparison of neutrophils versus effector memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v5.1) 5.176E-6 5.070E-4 4.693E-3 3.042E-2 8 200
50 GSE39152 BRAIN VS SPLEEN CD103 NEG MEMORY CD8 TCELL UP Genes up-regulated in memory CD8 T cells, ITGAE- [GeneID=3682] population: brain versus spleen sources. MSigDB C7: Immunologic Signatures (v5.1) 5.176E-6 5.070E-4 4.693E-3 3.042E-2 8 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2479 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 endothelial Top 500 All endothelial Top 500 All Brain Map - Barres 1.066E-6 2.018E-3 1.694E-2 2.643E-3 13 496
2 mendel RNAseq e17.5 Urothelium ShhCreRFP 2500 K1 mendel RNAseq e17.5 Urothelium ShhCreRFP 2500 K1 Gudmap RNAseq 1.628E-6 2.018E-3 1.694E-2 4.036E-3 18 989
3 PCBC ratio EB BM CD34+ vs EB blastocyst cfr-2X-p05 EB BM CD34+ vs EB blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.560E-6 2.942E-3 2.469E-2 8.826E-3 6 83
4 microglia Top 500 All microglia Top 500 All Brain Map - Barres 3.251E-5 2.015E-2
1.691E-1
8.058E-2
 11 491
5 gudmap RNAseq p2 Glomerlular Endothelial 2500 K2 gudmap RNAseq p2 Glomerlular Endothelial 2500 K2 Gudmap RNAseq 6.028E-5 2.968E-2
2.491E-1
1.494E-1
 8 270
6 JC hmvEC 2500 K4 JC hmvEC top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 7.778E-5 2.968E-2
2.491E-1
1.928E-1
 11 541
7 GSM538309 500 NK cells, NK.MCMV1.Sp, CD3-,NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 8.881E-5 2.968E-2
2.491E-1
2.202E-1
 9 367
8 gudmap dev gonad e11.5 F GonMes Sma k3 500 dev gonad e11.5 F GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 9.947E-5 2.968E-2
2.491E-1
2.466E-1
 6 149
9 GSM399362 500 alpha beta T cells, T.4+8int.Th, 4+ 8int TCRhi, Thymus, avg-3 Immgen.org, GSE15907 1.311E-4 2.968E-2
2.491E-1
3.251E-1
 8 302
10 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 500 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.386E-4 2.968E-2
2.491E-1
3.435E-1
 4 53
11 GSM399394 500 alpha beta T cells, T.DP69+.Th, 4+ 8+ TCRlo/int 69+, Thymus, avg-3 Immgen.org, GSE15907 1.403E-4 2.968E-2
2.491E-1
3.479E-1
 8 305
12 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 1000 k2 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.478E-4 2.968E-2
2.491E-1
3.663E-1
 5 101
13 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 k1 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.703E-4 2.968E-2
2.491E-1
4.222E-1
 3 22
14 OPC Top 500 All OPC Top 500 All Brain Map - Barres 1.732E-4 2.968E-2
2.491E-1
4.294E-1
 10 494
15 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 Gudmap RNAseq 1.796E-4 2.968E-2
2.491E-1
4.452E-1
 9 403
16 Lungmap Mouse e18.5 Epithelial (GSE52583) SubClass Clara Top 500 Cluster 4 Mouse Lung E18.5 Epithelial Clara c4 Lungmap Mouse Single Cell (Lungmap.net) 1.917E-4 2.970E-2
2.493E-1
4.752E-1
 6 168
17 GSM605756 500 alpha beta T cells, T.4.Pa.BDC, 4+ 8- BDC+, Pancreas, avg-2 Immgen.org, GSE15907 2.302E-4 3.329E-2
2.794E-1
5.706E-1
 8 328
18 GSM538329 500 alpha beta T cells, NKT.4-.Sp, TCRbeta+ aGalCer tet+ CD4-, Spleen, avg-3 Immgen.org, GSE15907 2.498E-4 3.329E-2
2.794E-1
6.192E-1
 8 332
19 gudmap dev gonad e11.5 M GonMes Sma k3 500 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 2.551E-4 3.329E-2
2.794E-1
6.325E-1
 4 62
20 gudmap RNAseq p2 CD2APMEISWT 2500 K4 gudmap RNAseq p2 CD2APMEISWT 2500 K4 Gudmap RNAseq 2.720E-4 3.371E-2
2.829E-1
6.742E-1
 13 843
21 GSM399400 500 alpha beta T cells, T.DPsm.Th, 4+ 8+ TCR-/lo FSClo, Thymus, avg-3 Immgen.org, GSE15907 3.109E-4 3.579E-2
3.003E-1
7.707E-1
 8 343
22 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 k5 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.176E-4 3.579E-2
3.003E-1
7.873E-1
 5 119
23 GSM538318 500 alpha beta T cells, NKT.4+.Lv, CD45 TCRb aGalCer-loaded CD1d tet CD4, Liver, avg-4 Immgen.org, GSE15907 3.626E-4 3.908E-2
3.280E-1
8.989E-1
 8 351
24 gudmap developingKidney e15.5 Endothelial cells 1000 DevelopingKidney e15.5 Endothelial cells emap-29965 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 3.884E-4 3.950E-2
3.315E-1
9.629E-1
 12 761
25 GSM538409 500 alpha beta T cells, T.8Nve.MLN, 4- 8+ 25- 62Lhi 44lo, Lymph Node, avg-3 Immgen.org, GSE15907 3.984E-4 3.950E-2
3.315E-1
9.876E-1
 8 356
26 GSM538371 500 alpha beta T cells, T.4Mem44h62l.Sp, CD4 TCRb CD44hi CD62Llo, Spleen, avg-3 Immgen.org, GSE15907 4.212E-4 4.005E-2
3.361E-1
1.000E0
 8 359
27 gudmap dev gonad e11.5 M GonMes Sma k4 200 dev gonad e11.5 M GonMes Sma k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.362E-4 4.005E-2
3.361E-1
1.000E0
 3 30
28 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr mesench 100 k4 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr mesench emap-3087 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 5.032E-4 4.455E-2
3.739E-1
1.000E0
 2 7
29 GSM538323 100 alpha beta T cells, NKT.4+.Sp, TCRb aGalCer-loaded CD1d-tetramer CD4, Spleen, avg-2 Immgen.org, GSE15907 5.847E-4 4.861E-2
4.080E-1
1.000E0
 4 77
30 GSM399367 500 alpha beta T cells, T.4int8+.Th, 4int 8+ TCRhi, Thymus, avg-3 Immgen.org, GSE15907 5.964E-4 4.861E-2
4.080E-1
1.000E0
 7 289
31 gudmap developingKidney e15.5 Endothelial cells 1000 k4 DevelopingKidney e15.5 Endothelial cells emap-29965 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.443E-4 4.861E-2
4.080E-1
1.000E0
 4 79
32 gudmap developingKidney e15.5 Endothelial cells 500 DevelopingKidney e15.5 Endothelial cells emap-29965 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 6.555E-4 4.861E-2
4.080E-1
1.000E0
 8 384
33 GSM605820 500 Myeloid Cells, DC.103+11b-.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 6.555E-4 4.861E-2
4.080E-1
1.000E0
 8 384
34 GSM538332 500 alpha beta T cells, NKT.44+NK1.1+.Th, aGC CD1d tet CD3e CD44 NK1.1, Thymus, avg-3 Immgen.org, GSE15907 6.667E-4 4.861E-2
4.080E-1
1.000E0
 8 385
Show 29 more annotations

15: Computational [Display Chart] 432 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 123 Genes in module 123 MSigDb: C4 - CM: Cancer Modules 1.541E-12 6.659E-10 4.426E-9 6.659E-10 18 240
2 module 98 Genes in module 98 MSigDb: C4 - CM: Cancer Modules 5.400E-11 1.166E-8 7.753E-8 2.333E-8 20 381
3 module 198 Genes in module 198 MSigDb: C4 - CM: Cancer Modules 2.589E-8 3.728E-6 2.478E-5 1.118E-5 15 292
4 module 197 Genes in module 197 MSigDb: C4 - CM: Cancer Modules 2.260E-7 2.441E-5 1.622E-4 9.764E-5 11 170
5 module 252 Genes in module 252 MSigDb: C4 - CM: Cancer Modules 5.489E-7 4.742E-5 3.152E-4 2.371E-4 12 227
6 module 46 Genes in module 46 MSigDb: C4 - CM: Cancer Modules 2.618E-5 1.885E-3 1.253E-2 1.131E-2 13 386
7 module 75 Genes in module 75 MSigDb: C4 - CM: Cancer Modules 5.495E-4 3.391E-2
2.254E-1
2.374E-1
 11 391
8 module 15 Genes in module 15 MSigDb: C4 - CM: Cancer Modules 8.864E-4 4.786E-2
3.181E-1
3.829E-1
 10 350
Show 3 more annotations

16: MicroRNA [Display Chart] 1962 annotations before applied cutoff / 19844 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 miR-93:PicTar miR-93:PicTar PicTar 2.053E-6 3.017E-3 2.462E-2 4.029E-3 14 581
2 miR-372:PicTar miR-372:PicTar PicTar 3.680E-6 3.017E-3 2.462E-2 7.220E-3 14 611
3 hsa-miR-106a:TargetScan hsa-miR-106a:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
4 hsa-miR-20b:TargetScan hsa-miR-20b:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
5 hsa-miR-519d:TargetScan hsa-miR-519d:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
6 hsa-miR-93:TargetScan hsa-miR-93:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
7 hsa-miR-20a:TargetScan hsa-miR-20a:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
8 hsa-miR-17:TargetScan hsa-miR-17:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
9 hsa-miR-106b:TargetScan hsa-miR-106b:TargetScan TargetScan 1.384E-5 3.017E-3 2.462E-2 2.716E-2 17 986
10 miR-20a:PicTar miR-20a:PicTar PicTar 1.977E-5 3.346E-3 2.730E-2 3.880E-2 13 615
11 miR-106b:PicTar miR-106b:PicTar PicTar 2.046E-5 3.346E-3 2.730E-2 4.014E-2 13 617
12 hsa-miR-200c:PITA hsa-miR-200c:PITA TOP PITA 2.217E-5 3.346E-3 2.730E-2 4.350E-2 15 815
13 hsa-miR-200b:PITA hsa-miR-200b:PITA TOP PITA 2.217E-5 3.346E-3 2.730E-2 4.350E-2 15 815
14 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 2.572E-5 3.461E-3 2.824E-2
5.047E-2
 11 453
15 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 2.788E-5 3.461E-3 2.824E-2
5.470E-2
 11 457
16 miR-142-3p:PicTar miR-142-3p:PicTar PicTar 2.823E-5 3.461E-3 2.824E-2
5.538E-2
 7 167
17 miR-200b:PicTar miR-200b:PicTar PicTar 3.331E-5 3.702E-3 3.021E-2
6.535E-2
 11 466
18 miR-200c:PicTar miR-200c:PicTar PicTar 3.397E-5 3.702E-3 3.021E-2
6.664E-2
 11 467
19 miR-19b:PicTar miR-19b:PicTar PicTar 3.962E-5 3.932E-3 3.208E-2
7.774E-2
 12 564
20 hsa-miR-610:PITA hsa-miR-610:PITA TOP PITA 4.037E-5 3.932E-3 3.208E-2
7.921E-2
 6 120
21 miR-19a:PicTar miR-19a:PicTar PicTar 4.242E-5 3.932E-3 3.208E-2
8.324E-2
 12 568
22 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 4.609E-5 3.932E-3 3.208E-2
9.043E-2
 11 483
23 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 4.609E-5 3.932E-3 3.208E-2
9.043E-2
 11 483
24 ACACTAC,MIR-142-3P:MSigDB ACACTAC,MIR-142-3P:MSigDB MSigDB 4.853E-5 3.967E-3 3.237E-2
9.521E-2
 6 124
25 hsa-miR-142-3p:TargetScan hsa-miR-142-3p:TargetScan TargetScan 5.158E-5 4.048E-3 3.303E-2
1.012E-1
 8 250
26 hsa-miR-106b:PITA hsa-miR-106b:PITA TOP PITA 7.342E-5 4.623E-3 3.772E-2
1.440E-1
 14 800
27 hsa-miR-106a:PITA hsa-miR-106a:PITA TOP PITA 7.342E-5 4.623E-3 3.772E-2
1.440E-1
 14 800
28 hsa-miR-20a:PITA hsa-miR-20a:PITA TOP PITA 7.342E-5 4.623E-3 3.772E-2
1.440E-1
 14 800
29 hsa-miR-17:PITA hsa-miR-17:PITA TOP PITA 7.342E-5 4.623E-3 3.772E-2
1.440E-1
 14 800
30 hsa-miR-93:PITA hsa-miR-93:PITA TOP PITA 7.342E-5 4.623E-3 3.772E-2
1.440E-1
 14 800
31 hsa-miR-20b:PITA hsa-miR-20b:PITA TOP PITA 7.342E-5 4.623E-3 3.772E-2
1.440E-1
 14 800
32 hsa-miR-519d:PITA hsa-miR-519d:PITA TOP PITA 7.540E-5 4.623E-3 3.772E-2
1.479E-1
 14 802
33 hsa-miR-548k:PITA hsa-miR-548k:PITA TOP PITA 9.070E-5 5.004E-3 4.083E-2
1.780E-1
 11 521
34 hsa-miR-429:PITA hsa-miR-429:PITA TOP PITA 9.298E-5 5.004E-3 4.083E-2
1.824E-1
 14 818
35 CAGTATT,MIR-200B:MSigDB CAGTATT,MIR-200B:MSigDB MSigDB 9.436E-5 5.004E-3 4.083E-2
1.851E-1
 10 434
36 CAGTATT,MIR-429:MSigDB CAGTATT,MIR-429:MSigDB MSigDB 9.436E-5 5.004E-3 4.083E-2
1.851E-1
 10 434
37 CAGTATT,MIR-200C:MSigDB CAGTATT,MIR-200C:MSigDB MSigDB 9.436E-5 5.004E-3 4.083E-2
1.851E-1
 10 434
38 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 1.096E-4 5.660E-3 4.618E-2
2.151E-1
 10 442
39 hsa-miR-1283:PITA hsa-miR-1283:PITA TOP PITA 1.280E-4 6.324E-3
5.160E-2
2.512E-1
 12 638
40 hsa-miR-19b:PITA hsa-miR-19b:PITA TOP PITA 1.322E-4 6.324E-3
5.160E-2
2.593E-1
 13 741
41 hsa-miR-19a:PITA hsa-miR-19a:PITA TOP PITA 1.322E-4 6.324E-3
5.160E-2
2.593E-1
 13 741
42 hsa-miR-144:TargetScan hsa-miR-144:TargetScan TargetScan 1.459E-4 6.456E-3
5.268E-2
2.862E-1
 12 647
43 GCACTTT,MIR-17-5P:MSigDB GCACTTT,MIR-17-5P:MSigDB MSigDB 1.580E-4 6.456E-3
5.268E-2
3.099E-1
 11 555
44 GCACTTT,MIR-106B:MSigDB GCACTTT,MIR-106B:MSigDB MSigDB 1.580E-4 6.456E-3
5.268E-2
3.099E-1
 11 555
45 GCACTTT,MIR-106A:MSigDB GCACTTT,MIR-106A:MSigDB MSigDB 1.580E-4 6.456E-3
5.268E-2
3.099E-1
 11 555
46 GCACTTT,MIR-20B:MSigDB GCACTTT,MIR-20B:MSigDB MSigDB 1.580E-4 6.456E-3
5.268E-2
3.099E-1
 11 555
47 GCACTTT,MIR-519D:MSigDB GCACTTT,MIR-519D:MSigDB MSigDB 1.580E-4 6.456E-3
5.268E-2
3.099E-1
 11 555
48 GCACTTT,MIR-20A:MSigDB GCACTTT,MIR-20A:MSigDB MSigDB 1.580E-4 6.456E-3
5.268E-2
3.099E-1
 11 555
49 hsa-miR-338-5p:PITA hsa-miR-338-5p:PITA TOP PITA 2.002E-4 8.017E-3
6.541E-2
3.928E-1
 13 773
50 miR-142-5p:PicTar miR-142-5p:PicTar PicTar 2.180E-4 8.556E-3
6.981E-2
4.278E-1
 8 308
Show 45 more annotations

17: Drug [Display Chart] 18621 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000005562 A25618 Stitch 1.391E-19 2.590E-15 2.696E-14 2.590E-15 30 777
2 CID000003154 Cosopt Stitch 5.657E-12 5.266E-8 5.482E-7 1.053E-7 16 341
3 D014118 Toxins, Biological CTD 9.287E-12 5.765E-8 6.000E-7 1.729E-7 20 619
4 D003474 Curcumin CTD 1.894E-11 8.817E-8 9.178E-7 3.527E-7 22 804
5 965 UP felodipine; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 2.722E-11 1.014E-7 1.055E-6 5.068E-7 12 170
6 D000111 Acetylcysteine CTD 1.511E-10 4.169E-7 4.340E-6 2.814E-6 20 724
7 D004137 Dinitrochlorobenzene CTD 1.567E-10 4.169E-7 4.340E-6 2.919E-6 15 362
8 5310 UP Puromycin dihydrochloride [58-58-2]; Up 200; 7.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.274E-10 9.947E-7 1.035E-5 7.958E-6 11 168
9 C007262 deoxynivalenol CTD 5.559E-10 1.150E-6 1.197E-5 1.035E-5 16 465
10 CID000004261 MS-275 Stitch 2.176E-9 4.052E-6 4.218E-5 4.052E-5 10 149
11 1520 UP Azacyclonol [115-46-8]; Up 200; 15uM; MCF7; HT HG-U133A Broad Institute CMAP 3.000E-9 5.078E-6 5.286E-5 5.586E-5 10 154
12 C093642 SB 203580 CTD 5.057E-9 7.847E-6 8.168E-5 9.416E-5 13 329
13 486 UP calmidazolium chloride; Up 200; 5uM; MCF7; HG-U133A Broad Institute CMAP 5.847E-9 8.376E-6 8.719E-5 1.089E-4 10 165
14 D002211 Capsaicin CTD 8.260E-9 1.060E-5 1.104E-4 1.538E-4 15 484
15 D019821 Simvastatin CTD 8.542E-9 1.060E-5 1.104E-4 1.591E-4 16 563
16 949 UP 5255229; Up 200; 13uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.221E-9 1.073E-5 1.117E-4 1.717E-4 10 173
17 C113580 U 0126 CTD 1.155E-8 1.203E-5 1.253E-4 2.150E-4 14 422
18 CID000001292 PPCM Stitch 1.163E-8 1.203E-5 1.253E-4 2.166E-4 7 59
19 CID000032744 polyinosinic-polycytidylic acid Stitch 1.276E-8 1.250E-5 1.301E-4 2.375E-4 12 291
20 D003520 Cyclophosphamide CTD 2.034E-8 1.893E-5 1.971E-4 3.787E-4 16 599
21 D009538 Nicotine CTD 2.166E-8 1.920E-5 1.999E-4 4.033E-4 20 968
22 C027576 4-hydroxy-2-nonenal CTD 2.431E-8 2.058E-5 2.142E-4 4.527E-4 18 783
23 C005961 bis(tri-n-butyltin)oxide CTD 2.968E-8 2.385E-5 2.483E-4 5.527E-4 15 533
24 D010081 Oxazolone CTD 3.112E-8 2.385E-5 2.483E-4 5.795E-4 11 253
25 C430898 AGN 194204 CTD 3.202E-8 2.385E-5 2.483E-4 5.962E-4 9 147
26 C038459 curdlan CTD 4.064E-8 2.911E-5 3.030E-4 7.568E-4 8 107
27 6823 UP Terfenadine [50679-08-8]; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP 4.279E-8 2.951E-5 3.072E-4 7.968E-4 9 152
28 D004008 Diclofenac CTD 5.164E-8 3.325E-5 3.461E-4 9.615E-4 15 556
29 CID000193659 EW-1 Stitch 5.178E-8 3.325E-5 3.461E-4 9.641E-4 5 22
30 1010 UP thioridazine hydrochloride; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 5.357E-8 3.325E-5 3.461E-4 9.975E-4 9 156
31 C568608 PCI 5002 CTD 5.719E-8 3.435E-5 3.576E-4 1.065E-3 17 735
32 1791 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; PC3; HT HG-U133A Broad Institute CMAP 5.979E-8 3.479E-5 3.622E-4 1.113E-3 9 158
33 C008493 methylselenic acid CTD 6.229E-8 3.491E-5 3.634E-4 1.160E-3 13 407
34 CID000435143 NSC-364372 Stitch 6.374E-8 3.491E-5 3.634E-4 1.187E-3 14 484
35 7188 UP Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 8.241E-8 4.384E-5 4.564E-4 1.534E-3 9 164
36 5324 UP Digoxin [20830-75-5]; Up 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP 9.145E-8 4.718E-5 4.911E-4 1.703E-3 9 166
37 1626 UP Etoposide [33419-42-0]; Up 200; 6.8uM; HL60; HG-U133A Broad Institute CMAP 9.628E-8 4.718E-5 4.911E-4 1.793E-3 9 167
38 4801 UP Digitoxigenin [143-62-4]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP 9.628E-8 4.718E-5 4.911E-4 1.793E-3 9 167
39 C020806 tetrabromobisphenol A CTD 1.052E-7 4.948E-5 5.151E-4 1.959E-3 16 675
40 CID000114777 theaflavin Stitch 1.065E-7 4.948E-5 5.151E-4 1.984E-3 10 224
41 D000841 Anisomycin CTD 1.089E-7 4.948E-5 5.151E-4 2.029E-3 7 81
42 CID000176155 SB203580 Stitch 1.155E-7 5.043E-5 5.250E-4 2.151E-3 17 772
43 CID000213546 poly(I-C Stitch 1.179E-7 5.043E-5 5.250E-4 2.196E-3 9 171
44 C061133 tamibarotene CTD 1.192E-7 5.043E-5 5.250E-4 2.219E-3 15 593
45 CID000005040 NSC226080 Stitch 1.412E-7 5.844E-5 6.083E-4 2.630E-3 17 783
46 992 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.508E-7 6.106E-5 6.356E-4 2.809E-3 9 176
47 6493 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP 1.583E-7 6.272E-5 6.528E-4 2.948E-3 9 177
48 2850 UP Nifuroxazide [965-52-6]; Up 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.661E-7 6.443E-5 6.707E-4 3.093E-3 9 178
49 CID000200878 P-38 Stitch 1.826E-7 6.669E-5 6.942E-4 3.399E-3 15 613
50 CID000107707 Zlllal Stitch 1.826E-7 6.669E-5 6.942E-4 3.399E-3 15 613
Show 45 more annotations

18: Disease [Display Chart] 2008 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0598766 Leukemogenesis DisGeNET BeFree 1.959E-14 3.933E-11 3.218E-10 3.933E-11 26 660
2 umls:C0085669 Acute leukemia DisGeNET BeFree 1.196E-12 1.201E-9 9.827E-9 2.402E-9 21 478
3 umls:C0023470 Myeloid Leukemia DisGeNET Curated 4.957E-12 3.318E-9 2.715E-8 9.953E-9 20 458
4 umls:C0023449 Acute lymphocytic leukemia DisGeNET Curated 1.547E-11 7.764E-9 6.353E-8 3.105E-8 25 811
5 umls:C1961102 Precursor Cell Lymphoblastic Leukemia Lymphoma DisGeNET Curated 8.322E-11 3.342E-8 2.735E-7 1.671E-7 23 733
6 umls:C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 4.040E-10 1.352E-7 1.106E-6 8.112E-7 18 461
7 umls:C2931822 Nasopharyngeal carcinoma DisGeNET Curated 2.845E-9 8.161E-7 6.678E-6 5.713E-6 20 656
8 umls:C1333064 Classical Hodgkin's Lymphoma DisGeNET BeFree 5.573E-9 1.296E-6 1.061E-5 1.119E-5 10 126
9 umls:C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 5.811E-9 1.296E-6 1.061E-5 1.167E-5 16 419
10 umls:C0015625 Fanconi Anemia DisGeNET Curated 3.665E-8 7.168E-6 5.865E-5 7.359E-5 12 245
11 umls:C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 4.232E-8 7.168E-6 5.865E-5 8.497E-5 14 358
12 umls:C0011615 Dermatitis, Atopic DisGeNET Curated 4.284E-8 7.168E-6 5.865E-5 8.601E-5 15 419
13 umls:C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 1.092E-7 1.686E-5 1.380E-4 2.192E-4 11 219
14 umls:C0023492 Leukemia, T-Cell DisGeNET Curated 1.415E-7 1.968E-5 1.611E-4 2.841E-4 13 334
15 umls:C0013595 Eczema DisGeNET Curated 1.470E-7 1.968E-5 1.611E-4 2.953E-4 14 396
16 umls:C0280100 Solid tumour DisGeNET BeFree 2.228E-7 2.796E-5 2.287E-4 4.473E-4 19 772
17 umls:C0206180 Ki-1+ Anaplastic Large Cell Lymphoma DisGeNET Curated 4.297E-7 5.076E-5 4.153E-4 8.629E-4 11 251
18 umls:C0079744 Diffuse Large B-Cell Lymphoma DisGeNET Curated 4.775E-7 5.327E-5 4.359E-4 9.588E-4 15 505
19 umls:C0019829 Hodgkin Disease DisGeNET Curated 8.548E-7 8.844E-5 7.236E-4 1.716E-3 12 328
20 umls:C0011644 Scleroderma DisGeNET BeFree 8.809E-7 8.844E-5 7.236E-4 1.769E-3 9 166
21 umls:C0014859 Esophageal Neoplasms DisGeNET Curated 1.704E-6 1.579E-4 1.292E-3 3.421E-3 15 559
22 umls:C0040128 Thyroid Diseases DisGeNET Curated 1.730E-6 1.579E-4 1.292E-3 3.474E-3 7 93
23 umls:C2745900 Promyelocytic leukemia DisGeNET BeFree 2.170E-6 1.894E-4 1.550E-3 4.357E-3 10 238
24 umls:C0853879 Invasive breast carcinoma DisGeNET BeFree 2.918E-6 2.441E-4 1.998E-3 5.859E-3 12 369
25 umls:C0042769 Virus Diseases DisGeNET Curated 3.235E-6 2.598E-4 2.126E-3 6.496E-3 17 750
26 umls:C0085110 Severe Combined Immunodeficiency DisGeNET Curated 4.112E-6 3.175E-4 2.598E-3 8.256E-3 14 524
27 umls:C0079772 T-Cell Lymphoma DisGeNET Curated 4.614E-6 3.410E-4 2.791E-3 9.264E-3 10 259
28 umls:C0023452 Leukemia, Lymphocytic, Acute, L1 DisGeNET Curated 4.756E-6 3.410E-4 2.791E-3 9.549E-3 12 387
29 umls:C0023448 Lymphoid leukemia DisGeNET Curated 5.449E-6 3.773E-4 3.087E-3 1.094E-2 9 207
30 umls:C0033860 Psoriasis DisGeNET Curated 7.172E-6 4.801E-4 3.928E-3 1.440E-2 15 629
31 umls:C0432487 Post-transplant lymphoproliferative disorder DisGeNET BeFree 9.292E-6 6.019E-4 4.925E-3 1.866E-2 4 22
32 umls:C0034067 Pulmonary Emphysema DisGeNET Curated 1.238E-5 7.601E-4 6.219E-3 2.486E-2 8 174
33 umls:C0014175 Endometriosis DisGeNET Curated 1.249E-5 7.601E-4 6.219E-3 2.508E-2 15 659
34 umls:C0024305 Lymphoma, Non-Hodgkin DisGeNET Curated 1.766E-5 1.043E-3 8.534E-3 3.546E-2 10 302
35 umls:C0004364 Autoimmune Diseases DisGeNET Curated 1.837E-5 1.054E-3 8.624E-3 3.689E-2 16 767
36 umls:C0024138 Lupus Erythematosus, Discoid DisGeNET BeFree 1.978E-5 1.103E-3 9.026E-3 3.971E-2 10 306
37 umls:C0409974 Lupus Erythematosus DisGeNET BeFree 2.091E-5 1.135E-3 9.287E-3 4.200E-2 10 308
38 umls:C2004493 Leukemia, B-Cell DisGeNET BeFree 2.247E-5 1.188E-3 9.717E-3 4.513E-2 6 92
39 umls:C0036421 Systemic Scleroderma DisGeNET Curated 2.356E-5 1.213E-3 9.927E-3 4.732E-2 13 531
40 umls:C0007847 Malignant tumor of cervix DisGeNET BeFree 2.979E-5 1.496E-3 1.224E-2
5.982E-2
 17 889
41 umls:C0033578 Prostatic Neoplasms DisGeNET Curated 3.199E-5 1.558E-3 1.275E-2
6.424E-2
 18 988
42 umls:C0008312 Primary biliary cirrhosis DisGeNET Curated 3.258E-5 1.558E-3 1.275E-2
6.543E-2
 9 259
43 umls:C1168401 Squamous cell carcinoma of the head and neck DisGeNET Curated 4.321E-5 2.018E-3 1.651E-2
8.676E-2
 16 823
44 umls:C1332153 Acute Myeloid Leukemia Arising from Previous Myelodysplastic Syndrome DisGeNET BeFree 4.933E-5 2.251E-3 1.842E-2
9.906E-2
 4 33
45 umls:C0019163 Hepatitis B DisGeNET Curated 5.342E-5 2.271E-3 1.858E-2
1.073E-1
 15 747
46 umls:C0546837 Malignant neoplasm of esophagus DisGeNET Curated 5.363E-5 2.271E-3 1.858E-2
1.077E-1
 13 575
47 umls:C0026499 Monosomy DisGeNET BeFree 5.390E-5 2.271E-3 1.858E-2
1.082E-1
 7 157
48 umls:C0024312 Lymphopenia DisGeNET Curated 5.453E-5 2.271E-3 1.858E-2
1.095E-1
 5 66
49 umls:C0004943 Behcet Syndrome DisGeNET Curated 5.641E-5 2.271E-3 1.858E-2
1.133E-1
 8 215
50 umls:C0152018 Esophageal carcinoma DisGeNET Curated 5.655E-5 2.271E-3 1.858E-2
1.136E-1
 13 578
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