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1: GO: Molecular Function [Display Chart] 431 annotations before applied cutoff / 18819 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004812 aminoacyl-tRNA ligase activity 6.780E-10 9.741E-8 6.472E-7 2.922E-7 8 44
2 GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds 6.780E-10 9.741E-8 6.472E-7 2.922E-7 8 44
3 GO:0016875 ligase activity, forming carbon-oxygen bonds 6.780E-10 9.741E-8 6.472E-7 2.922E-7 8 44
4 GO:0003697 single-stranded DNA binding 9.155E-6 9.865E-4 6.555E-3 3.946E-3 7 105
5 GO:0001069 regulatory region RNA binding 1.458E-4 1.257E-2
8.352E-2
6.285E-2
 2 3
6 GO:0043021 ribonucleoprotein complex binding 2.308E-4 1.658E-2
1.102E-1
9.949E-2
 6 123
7 GO:0000049 tRNA binding 3.837E-4 2.363E-2
1.570E-1
1.654E-1
 4 49
8 GO:0016874 ligase activity 6.980E-4 3.443E-2
2.288E-1
3.008E-1
 10 415
9 GO:0055131 C3HC4-type RING finger domain binding 7.190E-4 3.443E-2
2.288E-1
3.099E-1
 2 6
10 GO:0042299 lupeol synthase activity 1.330E-3 3.821E-2
2.539E-1
5.732E-1
 2 8
11 GO:0080011 baruol synthase activity 1.330E-3 3.821E-2
2.539E-1
5.732E-1
 2 8
12 GO:0034784 pivalyl-CoA mutase activity 1.330E-3 3.821E-2
2.539E-1
5.732E-1
 2 8
13 GO:0042300 beta-amyrin synthase activity 1.330E-3 3.821E-2
2.539E-1
5.732E-1
 2 8
14 GO:0034951 o-hydroxylaminobenzoate mutase activity 1.330E-3 3.821E-2
2.539E-1
5.732E-1
 2 8
15 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 1.330E-3 3.821E-2
2.539E-1
5.732E-1
 2 8
16 GO:0031559 oxidosqualene cyclase activity 1.702E-3 4.325E-2
2.874E-1
7.336E-1
 2 9
17 GO:0003729 mRNA binding 1.706E-3 4.325E-2
2.874E-1
7.353E-1
 6 180
Show 12 more annotations

2: GO: Biological Process [Display Chart] 2277 annotations before applied cutoff / 18785 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006412 translation 1.250E-9 1.026E-6 8.522E-6 2.847E-6 22 667
2 GO:0006418 tRNA aminoacylation for protein translation 1.599E-9 1.026E-6 8.522E-6 3.641E-6 8 49
3 GO:0034660 ncRNA metabolic process 2.188E-9 1.026E-6 8.522E-6 4.981E-6 20 563
4 GO:0043039 tRNA aminoacylation 2.622E-9 1.026E-6 8.522E-6 5.971E-6 8 52
5 GO:0043043 peptide biosynthetic process 2.742E-9 1.026E-6 8.522E-6 6.243E-6 22 696
6 GO:0043038 amino acid activation 3.071E-9 1.026E-6 8.522E-6 6.992E-6 8 53
7 GO:0044265 cellular macromolecule catabolic process 3.154E-9 1.026E-6 8.522E-6 7.181E-6 26 978
8 GO:0043604 amide biosynthetic process 2.155E-8 6.135E-6 5.097E-5 4.908E-5 22 780
9 GO:0006402 mRNA catabolic process 4.160E-8 1.053E-5 8.745E-5 9.473E-5 12 218
10 GO:0006399 tRNA metabolic process 5.394E-8 1.228E-5 1.020E-4 1.228E-4 11 180
11 GO:0006518 peptide metabolic process 9.398E-8 1.945E-5 1.616E-4 2.140E-4 22 848
12 GO:0006401 RNA catabolic process 1.629E-7 3.091E-5 2.568E-4 3.709E-4 12 247
13 GO:0010608 posttranscriptional regulation of gene expression 2.268E-7 3.973E-5 3.301E-4 5.165E-4 16 478
14 GO:0000956 nuclear-transcribed mRNA catabolic process 1.543E-6 2.510E-4 2.085E-3 3.513E-3 10 202
15 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay 2.097E-6 3.184E-4 2.645E-3 4.776E-3 8 121
16 GO:0016071 mRNA metabolic process 3.832E-6 5.453E-4 4.530E-3 8.725E-3 17 665
17 GO:0006450 regulation of translational fidelity 5.011E-6 6.711E-4 5.576E-3 1.141E-2 4 17
18 GO:0006417 regulation of translation 6.132E-6 7.506E-4 6.236E-3 1.396E-2 12 349
19 GO:0035967 cellular response to topologically incorrect protein 6.568E-6 7.506E-4 6.236E-3 1.496E-2 8 141
20 GO:0019080 viral gene expression 6.593E-6 7.506E-4 6.236E-3 1.501E-2 9 187
21 GO:0044033 multi-organism metabolic process 1.492E-5 1.572E-3 1.306E-2 3.397E-2 9 207
22 GO:0034248 regulation of cellular amide metabolic process 1.518E-5 1.572E-3 1.306E-2 3.457E-2 12 382
23 GO:0032479 regulation of type I interferon production 1.792E-5 1.760E-3 1.462E-2 4.080E-2 7 117
24 GO:0019941 modification-dependent protein catabolic process 1.855E-5 1.760E-3 1.462E-2 4.224E-2 15 598
25 GO:0032606 type I interferon production 2.000E-5 1.822E-3 1.514E-2 4.555E-2 7 119
26 GO:0043632 modification-dependent macromolecule catabolic process 2.165E-5 1.896E-3 1.575E-2 4.930E-2 15 606
27 GO:0006448 regulation of translational elongation 2.998E-5 2.528E-3 2.100E-2
6.826E-2
 4 26
28 GO:0019083 viral transcription 3.290E-5 2.675E-3 2.223E-2
7.491E-2
 8 176
29 GO:0030968 endoplasmic reticulum unfolded protein response 3.541E-5 2.780E-3 2.310E-2
8.063E-2
 7 130
30 GO:0034655 nucleobase-containing compound catabolic process 3.675E-5 2.790E-3 2.318E-2
8.369E-2
 12 418
31 GO:0034620 cellular response to unfolded protein 4.098E-5 3.010E-3 2.501E-2
9.332E-2
 7 133
32 GO:0035966 response to topologically incorrect protein 4.514E-5 3.212E-3 2.668E-2
1.028E-1
 8 184
33 GO:0051603 proteolysis involved in cellular protein catabolic process 5.951E-5 4.106E-3 3.412E-2
1.355E-1
 15 662
34 GO:0006396 RNA processing 6.522E-5 4.368E-3 3.629E-2
1.485E-1
 18 914
35 GO:0019058 viral life cycle 7.003E-5 4.556E-3 3.785E-2
1.595E-1
 12 447
36 GO:0006613 cotranslational protein targeting to membrane 7.557E-5 4.780E-3 3.971E-2
1.721E-1
 6 101
37 GO:0044270 cellular nitrogen compound catabolic process 9.574E-5 5.831E-3 4.844E-2
2.180E-1
 12 462
38 GO:0046700 heterocycle catabolic process 9.971E-5 5.831E-3 4.844E-2
2.270E-1
 12 464
39 GO:0034976 response to endoplasmic reticulum stress 1.021E-4 5.831E-3 4.844E-2
2.325E-1
 9 265
40 GO:0044257 cellular protein catabolic process 1.024E-4 5.831E-3 4.844E-2
2.332E-1
 15 695
41 GO:0034470 ncRNA processing 1.123E-4 6.237E-3
5.182E-2
2.557E-1
 11 399
42 GO:0019439 aromatic compound catabolic process 1.218E-4 6.603E-3
5.486E-2
2.773E-1
 12 474
43 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process 1.286E-4 6.810E-3
5.657E-2
2.928E-1
 5 70
44 GO:0010498 proteasomal protein catabolic process 1.831E-4 9.477E-3
7.874E-2
4.170E-1
 11 422
45 GO:0071426 ribonucleoprotein complex export from nucleus 1.956E-4 9.680E-3
8.042E-2
4.453E-1
 6 120
46 GO:0006405 RNA export from nucleus 1.956E-4 9.680E-3
8.042E-2
4.453E-1
 6 120
47 GO:0006986 response to unfolded protein 2.207E-4 1.028E-2
8.543E-2
5.025E-1
 7 174
48 GO:0031329 regulation of cellular catabolic process 2.209E-4 1.028E-2
8.543E-2
5.030E-1
 14 663
49 GO:0071166 ribonucleoprotein complex localization 2.237E-4 1.028E-2
8.543E-2
5.093E-1
 6 123
50 GO:0032480 negative regulation of type I interferon production 2.258E-4 1.028E-2
8.543E-2
5.141E-1
 4 43
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 308 annotations before applied cutoff / 19172 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005925 focal adhesion 8.802E-5 1.128E-2
7.118E-2
 2.711E-2 11 393
2 GO:0005924 cell-substrate adherens junction 9.843E-5 1.128E-2
7.118E-2
 3.032E-2 11 398
3 GO:0030055 cell-substrate junction 1.099E-4 1.128E-2
7.118E-2
 3.384E-2 11 403
4 GO:0044429 mitochondrial part 4.466E-4 2.319E-2
1.463E-1
1.375E-1
 17 988
5 GO:0097413 Lewy body 4.641E-4 2.319E-2
1.463E-1
1.429E-1
 2 5
6 GO:0032982 myosin filament 5.108E-4 2.319E-2
1.463E-1
1.573E-1
 3 23
7 GO:0005912 adherens junction 5.272E-4 2.319E-2
1.463E-1
1.624E-1
 11 484
8 GO:0070161 anchoring junction 7.244E-4 2.489E-2
1.570E-1
2.231E-1
 11 503
9 GO:0005759 mitochondrial matrix 7.273E-4 2.489E-2
1.570E-1
2.240E-1
 10 425
10 GO:0016460 myosin II complex 8.268E-4 2.547E-2
1.607E-1
2.547E-1
 3 27
11 GO:0022625 cytosolic large ribosomal subunit 1.177E-3 2.999E-2
1.892E-1
3.624E-1
 4 67
12 GO:0005840 ribosome 1.225E-3 2.999E-2
1.892E-1
3.773E-1
 7 235
13 GO:0005730 nucleolus 1.266E-3 2.999E-2
1.892E-1
3.899E-1
 15 894
14 GO:0022626 cytosolic ribosome 1.399E-3 3.078E-2
1.942E-1
4.309E-1
 5 119
15 GO:0016234 inclusion body 1.702E-3 3.495E-2
2.205E-1
5.243E-1
 4 74
16 GO:1990904 ribonucleoprotein complex 2.047E-3 3.647E-2
2.301E-1
6.306E-1
 13 751
17 GO:0030529 intracellular ribonucleoprotein complex 2.047E-3 3.647E-2
2.301E-1
6.306E-1
 13 751
18 GO:0005694 chromosome 2.131E-3 3.647E-2
2.301E-1
6.565E-1
 15 943
Show 13 more annotations

4: Human Phenotype [Display Chart] 166 annotations before applied cutoff / 1813 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 1518 annotations before applied cutoff / 9208 genes in category

No results to display

6: Domain [Display Chart] 751 annotations before applied cutoff / 16924 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001412 aa-tRNA-synth I CS InterPro 7.759E-6 3.669E-3 2.642E-2 5.827E-3 4 18
2 PS00178 AA TRNA LIGASE I PROSITE 9.772E-6 3.669E-3 2.642E-2 7.339E-3 4 19
3 IPR004009 Myosin N InterPro 1.638E-4 2.171E-2
1.563E-1
1.230E-1
 3 15
4 PF02736 Myosin N Pfam 1.638E-4 2.171E-2
1.563E-1
1.230E-1
 3 15
5 PF01576 Myosin tail 1 Pfam 2.422E-4 2.171E-2
1.563E-1
1.819E-1
 3 17
6 IPR002928 Myosin tail InterPro 2.422E-4 2.171E-2
1.563E-1
1.819E-1
 3 17
7 IPR014729 Rossmann-like a/b/a fold InterPro 2.477E-4 2.171E-2
1.563E-1
1.861E-1
 4 42
8 G3DSA:3.40.50.620 Rossmann-like a/b/a fold Gene3D 2.477E-4 2.171E-2
1.563E-1
1.861E-1
 4 42
9 IPR006195 Aminoacyl-tRNA-synth II InterPro 2.891E-4 2.171E-2
1.563E-1
2.171E-1
 3 18
10 PS50862 AA TRNA LIGASE II PROSITE 2.891E-4 2.171E-2
1.563E-1
2.171E-1
 3 18
11 PF00458 WHEP-TRS Pfam 5.249E-4 2.658E-2
1.914E-1
3.942E-1
 2 5
12 IPR000738 WHEP-TRS InterPro 5.249E-4 2.658E-2
1.914E-1
3.942E-1
 2 5
13 PS00762 WHEP TRS 1 PROSITE 5.249E-4 2.658E-2
1.914E-1
3.942E-1
 2 5
14 PS51185 WHEP TRS 2 PROSITE 5.249E-4 2.658E-2
1.914E-1
3.942E-1
 2 5
15 IPR000626 Ubiquitin InterPro 5.663E-4 2.658E-2
1.914E-1
4.253E-1
 4 52
16 IPR019955 Ubiquitin supergroup InterPro 5.663E-4 2.658E-2
1.914E-1
4.253E-1
 4 52
17 PS50053 UBIQUITIN 2 PROSITE 6.091E-4 2.691E-2
1.937E-1
4.575E-1
 4 53
18 IPR013155 V/L/I-tRNA-synth anticodon-bd InterPro 7.836E-4 2.942E-2
2.118E-1
5.885E-1
 2 6
19 PF08264 Anticodon 1 Pfam 7.836E-4 2.942E-2
2.118E-1
5.885E-1
 2 6
20 IPR009008 Val/Leu/Ile-tRNA-synth edit InterPro 7.836E-4 2.942E-2
2.118E-1
5.885E-1
 2 6
21 G3DSA:1.10.287.10 S15 NS1 RNA bd Gene3D 1.092E-3 3.565E-2
2.566E-1
8.199E-1
 2 7
22 PF00133 tRNA-synt 1 Pfam 1.092E-3 3.565E-2
2.566E-1
8.199E-1
 2 7
23 IPR002300 Aminoacyl-tRNA-synth Ia InterPro 1.092E-3 3.565E-2
2.566E-1
8.199E-1
 2 7
24 IPR009068 S15 NS1 RNA-bd InterPro 1.449E-3 4.326E-2
3.114E-1
1.000E0
 2 8
25 IPR015650 Myosin hc InterPro 1.854E-3 4.326E-2
3.114E-1
1.000E0
 2 9
26 PF00063 Myosin head Pfam 2.298E-3 4.326E-2
3.114E-1
1.000E0
 3 36
27 IPR001609 Myosin head motor dom InterPro 2.298E-3 4.326E-2
3.114E-1
1.000E0
 3 36
28 SM00242 MYSc SMART 2.298E-3 4.326E-2
3.114E-1
1.000E0
 3 36
29 PS00299 UBIQUITIN 1 PROSITE 2.298E-3 4.326E-2
3.114E-1
1.000E0
 3 36
30 IPR002314 aa-tRNA-synt IIb cons-dom InterPro 2.805E-3 4.326E-2
3.114E-1
1.000E0
 2 11
31 PF00587 tRNA-synt 2b Pfam 2.805E-3 4.326E-2
3.114E-1
1.000E0
 2 11
32 SM00213 UBQ SMART 3.578E-3 4.326E-2
3.114E-1
1.000E0
 3 42
33 IPR020103 PsdUridine synth cat dom InterPro 3.940E-3 4.326E-2
3.114E-1
1.000E0
 2 13
34 PF00240 ubiquitin Pfam 4.353E-3 4.326E-2
3.114E-1
1.000E0
 3 45
35 IPR018936 PI3/4 kinase CS InterPro 5.253E-3 4.326E-2
3.114E-1
1.000E0
 2 15
36 IPR001023 Hsp70 InterPro 5.253E-3 4.326E-2
3.114E-1
1.000E0
 2 15
37 IPR009080 tRNAsynth 1a anticodon-bd InterPro 5.253E-3 4.326E-2
3.114E-1
1.000E0
 2 15
38 G3DSA:1.10.1070.11 PI3/4 kinase cat Gene3D 5.975E-3 4.326E-2
3.114E-1
1.000E0
 2 16
39 SM00146 PI3Kc SMART 5.975E-3 4.326E-2
3.114E-1
1.000E0
 2 16
40 PF00012 HSP70 Pfam 5.975E-3 4.326E-2
3.114E-1
1.000E0
 2 16
41 PS01036 HSP70 3 PROSITE 6.739E-3 4.326E-2
3.114E-1
1.000E0
 2 17
42 PS00297 HSP70 1 PROSITE 6.739E-3 4.326E-2
3.114E-1
1.000E0
 2 17
43 PS00329 HSP70 2 PROSITE 6.739E-3 4.326E-2
3.114E-1
1.000E0
 2 17
44 PF08315 cwf18 Pfam 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
45 IPR005485 Ribosomal L5 euk InterPro 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
46 PF01777 Ribosomal L27e Pfam 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
47 IPR023033 Ala tRNA synth euk/bac InterPro 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
48 IPR019192 Ribosomal L28 mit InterPro 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
49 IPR023184 Ubol cytC Rdtase hinge dom InterPro 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
50 PS50935 SSB PROSITE 7.381E-3 4.326E-2
3.114E-1
1.000E0
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 619 annotations before applied cutoff / 10916 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 105980 tRNA Aminoacylation BioSystems: REACTOME 1.744E-9 1.080E-6 7.564E-6 1.080E-6 8 42
2 105981 Cytosolic tRNA aminoacylation BioSystems: REACTOME 3.620E-8 1.120E-5 7.850E-5 2.241E-5 6 24
3 83030 Aminoacyl-tRNA biosynthesis BioSystems: KEGG 7.198E-8 1.485E-5 1.040E-4 4.455E-5 8 66
4 MAP00970 Aminoacyl tRNA biosynthesis MAP00970 Aminoacyl tRNA biosynthesis GenMAPP 2.994E-7 4.634E-5 3.246E-4 1.853E-4 5 18
5 160950 Processing of Capped Intron-Containing Pre-mRNA BioSystems: REACTOME 2.625E-5 3.250E-3 2.277E-2 1.625E-2 8 143
6 106229 snRNP Assembly BioSystems: REACTOME 6.593E-5 4.218E-3 2.955E-2 4.081E-2 5 51
7 106228 Metabolism of non-coding RNA BioSystems: REACTOME 6.593E-5 4.218E-3 2.955E-2 4.081E-2 5 51
8 366241 Nonsense Mediated Decay Enhanced by the Exon Junction Complex BioSystems: REACTOME 6.686E-5 4.218E-3 2.955E-2 4.139E-2 8 163
9 366240 Nonsense-Mediated Decay BioSystems: REACTOME 6.686E-5 4.218E-3 2.955E-2 4.139E-2 8 163
10 105904 Unfolded Protein Response BioSystems: REACTOME 6.814E-5 4.218E-3 2.955E-2 4.218E-2 6 83
11 106068 Influenza Life Cycle BioSystems: REACTOME 2.013E-4 1.027E-2
7.192E-2
1.246E-1
 8 191
12 PW:0000241 schizophrenia Pathway Ontology 2.096E-4 1.027E-2
7.192E-2
1.298E-1
 2 3
13 366242 Nonsense Mediated Decay Independent of the Exon Junction Complex BioSystems: REACTOME 2.156E-4 1.027E-2
7.192E-2
1.335E-1
 7 145
14 106067 Influenza Infection BioSystems: REACTOME 2.401E-4 1.062E-2
7.439E-2
1.487E-1
 8 196
15 105951 mRNA Splicing BioSystems: REACTOME 3.553E-4 1.374E-2
9.630E-2
2.199E-1
 6 112
16 105952 mRNA Splicing - Major Pathway BioSystems: REACTOME 3.553E-4 1.374E-2
9.630E-2
2.199E-1
 6 112
17 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 5.089E-4 1.853E-2
1.298E-1
3.150E-1
 7 167
18 106230 Metabolism of proteins BioSystems: REACTOME 5.961E-4 2.050E-2
1.436E-1
3.690E-1
 15 689
19 105982 Mitochondrial tRNA aminoacylation BioSystems: REACTOME 6.903E-4 2.249E-2
1.576E-1
4.273E-1
 3 21
20 105906 Activation of Chaperones by IRE1alpha BioSystems: REACTOME 8.724E-4 2.700E-2
1.892E-1
5.400E-1
 4 51
21 198843 mRNA processing BioSystems: WikiPathways 9.932E-4 2.928E-2
2.051E-1
6.148E-1
 6 136
22 105978 Eukaryotic Translation Termination BioSystems: REACTOME 1.154E-3 3.248E-2
2.275E-1
7.145E-1
 6 140
23 105965 Translation BioSystems: REACTOME 1.788E-3 4.659E-2
3.264E-1
1.000E0
 7 207
24 105907 PERK regulated gene expression BioSystems: REACTOME 1.806E-3 4.659E-2
3.264E-1
1.000E0
 3 29
25 106080 Export of Viral Ribonucleoproteins from Nucleus BioSystems: REACTOME 1.995E-3 4.939E-2
3.460E-1
1.000E0
 3 30
Show 20 more annotations

8: Pubmed [Display Chart] 8596 annotations before applied cutoff / 51818 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22268729 Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. Pubmed 1.194E-18 1.027E-14 9.892E-14 1.027E-14 22 613
2 19738201 Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Pubmed 2.441E-17 1.049E-13 1.011E-12 2.099E-13 22 708
3 22623428 Proteomic analysis of ¿4ß1 integrin adhesion complexes reveals ¿-subunit-dependent protein recruitment. Pubmed 7.990E-17 2.289E-13 2.206E-12 6.868E-13 19 491
4 22681889 The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Pubmed 4.098E-15 8.806E-12 8.486E-11 3.523E-11 21 803
5 25963833 Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Pubmed 1.230E-13 2.115E-10 2.038E-9 1.058E-9 20 845
6 22586326 Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Pubmed 2.157E-12 3.090E-9 2.977E-8 1.854E-8 17 653
7 20458337 MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Pubmed 2.698E-12 3.313E-9 3.192E-8 2.319E-8 16 563
8 21319273 An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. Pubmed 3.855E-12 4.143E-9 3.992E-8 3.314E-8 14 397
9 18457437 Identification of intracellular proteins associated with the EBV-encoded nuclear antigen 5 using an efficient TAP procedure and FT-ICR mass spectrometry. Pubmed 1.165E-11 1.113E-8 1.073E-7 1.002E-7 10 152
10 23443559 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Pubmed 1.774E-11 1.525E-8 1.470E-7 1.525E-7 16 639
11 23246001 SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. Pubmed 5.068E-11 3.961E-8 3.817E-7 4.357E-7 11 239
12 23125841 Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1. Pubmed 5.541E-11 3.969E-8 3.825E-7 4.763E-7 11 241
13 25147182 Quantitative Lys-¿-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. Pubmed 6.614E-11 4.373E-8 4.214E-7 5.685E-7 13 401
14 23398456 The P-body component USP52/PAN2 is a novel regulator of HIF1A mRNA stability. Pubmed 9.281E-11 5.699E-8 5.492E-7 7.978E-7 12 328
15 22079093 Proteomic analysis of the 20S proteasome (PSMA3)-interacting proteins reveals a functional link between the proteasome and mRNA metabolism. Pubmed 1.636E-10 9.378E-8 9.037E-7 1.407E-6 8 93
16 20020773 Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery. Pubmed 5.067E-10 2.722E-7 2.623E-6 4.355E-6 10 223
17 17620599 Functional specialization of beta-arrestin interactions revealed by proteomic analysis. Pubmed 1.009E-9 5.100E-7 4.915E-6 8.670E-6 11 317
18 24797263 Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress. Pubmed 1.227E-9 5.861E-7 5.648E-6 1.055E-5 11 323
19 20877624 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. Pubmed 3.767E-9 1.619E-6 1.560E-5 3.239E-5 16 926
20 20877624:gr Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. GeneRIF 3.767E-9 1.619E-6 1.560E-5 3.239E-5 16 926
21 11790298 Directed proteomic analysis of the human nucleolus. Pubmed 5.227E-9 2.139E-6 2.062E-5 4.493E-5 9 208
22 21423176 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ß-Pix in negative regulation of focal adhesion maturation. Pubmed 5.548E-9 2.168E-6 2.089E-5 4.769E-5 10 286
23 15461802 A genome annotation-driven approach to cloning the human ORFeome. Pubmed 7.213E-9 2.696E-6 2.598E-5 6.200E-5 10 294
24 16009940 Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways. Pubmed 8.263E-9 2.960E-6 2.852E-5 7.103E-5 8 152
25 26641092 The Activation-Induced Assembly of an RNA/Protein Interactome Centered on the Splicing Factor U2AF2 Regulates Gene Expression in Human CD4 T Cells. Pubmed 1.743E-8 5.993E-6 5.775E-5 1.498E-4 9 239
26 25567808 Molecular determinants of force production in human skeletal muscle fibers: effects of myosin isoform expression and cross-sectional area. Pubmed 1.813E-8 5.993E-6 5.775E-5 1.558E-4 3 3
27 21630459 Proteomic characterization of the human sperm nucleus. Pubmed 2.768E-8 8.811E-6 8.491E-5 2.379E-4 11 437
28 21081666 Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Pubmed 3.364E-8 1.033E-5 9.953E-5 2.892E-4 9 258
29 17289661 Molecular composition of IMP1 ribonucleoprotein granules. Pubmed 4.236E-8 1.252E-5 1.206E-4 3.641E-4 5 36
30 19380743 Charting the molecular network of the drug target Bcr-Abl. Pubmed 4.369E-8 1.252E-5 1.206E-4 3.756E-4 9 266
31 23463506 The intracellular interactome of tetraspanin-enriched microdomains reveals their function as sorting machineries toward exosomes. Pubmed 1.093E-7 3.032E-5 2.922E-4 9.399E-4 8 212
32 19928837 The SMN interactome includes Myb-binding protein 1a. Pubmed 1.508E-7 4.051E-5 3.903E-4 1.296E-3 5 46
33 27499296 Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Pubmed 1.583E-7 4.124E-5 3.974E-4 1.361E-3 10 409
34 15635413 Nucleolar proteome dynamics. Pubmed 1.977E-7 4.998E-5 4.816E-4 1.699E-3 10 419
35 19167051 Importin 8 is a gene silencing factor that targets argonaute proteins to distinct mRNAs. Pubmed 3.154E-7 7.746E-5 7.465E-4 2.711E-3 6 101
36 17681147 Ufd1 is a cofactor of gp78 and plays a key role in cholesterol metabolism by regulating the stability of HMG-CoA reductase. Pubmed 3.595E-7 8.584E-5 8.271E-4 3.090E-3 3 6
37 15231747 A protein interaction framework for human mRNA degradation. Pubmed 4.123E-7 9.579E-5 9.231E-4 3.544E-3 9 347
38 12226669 Comprehensive proteomic analysis of the human spliceosome. Pubmed 4.953E-7 1.120E-4 1.080E-3 4.258E-3 6 109
39 25756610 DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Pubmed 5.499E-7 1.212E-4 1.168E-3 4.727E-3 7 179
40 21907836 Interactome study suggests multiple cellular functions of hepatoma-derived growth factor (HDGF). Pubmed 8.499E-7 1.826E-4 1.760E-3 7.306E-3 7 191
41 22944692 A catalogue of putative HIV-1 protease host cell substrates. Pubmed 1.057E-6 2.213E-4 2.132E-3 9.089E-3 6 124
42 24337577 Protein interaction screening for the ankyrin repeats and suppressor of cytokine signaling (SOCS) box (ASB) family identify Asb11 as a novel endoplasmic reticulum resident ubiquitin ligase. Pubmed 1.081E-6 2.213E-4 2.132E-3 9.293E-3 7 198
43 24639526 RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling. Pubmed 1.277E-6 2.494E-4 2.404E-3 1.097E-2 7 203
44 24244333 Profiling of Parkin-binding partners using tandem affinity purification. Pubmed 1.277E-6 2.494E-4 2.404E-3 1.097E-2 7 203
45 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 1.364E-6 2.605E-4 2.510E-3 1.172E-2 9 401
46 25468996 E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Pubmed 1.787E-6 3.316E-4 3.196E-3 1.536E-2 8 307
47 26752685 FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Pubmed 1.813E-6 3.316E-4 3.196E-3 1.559E-2 6 136
48 8722009 Structure and evolution of mammalian ribosomal proteins. Pubmed 2.461E-6 4.343E-4 4.185E-3 2.115E-2 5 80
49 20562859 Network organization of the human autophagy system. Pubmed 2.504E-6 4.343E-4 4.185E-3 2.153E-2 9 432
50 25277244 The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Pubmed 2.526E-6 4.343E-4 4.185E-3 2.171E-2 7 225
Show 45 more annotations

9: Interaction [Display Chart] 3749 annotations before applied cutoff / 16535 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:FBXO6 FBXO6 interactions 4.853E-9 1.819E-5 1.602E-4 1.819E-5 22 623
2 int:ITGA4 ITGA4 interactions 2.865E-8 5.371E-5 4.730E-4 1.074E-4 19 513
3 int:CUL5 CUL5 interactions 6.231E-8 7.786E-5 6.857E-4 2.336E-4 17 429
4 int:VCAM1 VCAM1 interactions 1.124E-7 1.054E-4 9.281E-4 4.215E-4 17 447
5 int:FN1 FN1 interactions 1.899E-7 1.424E-4 1.254E-3 7.120E-4 22 766
6 int:ISG15 ISG15 interactions 9.469E-7 5.916E-4 5.210E-3 3.550E-3 11 208
7 int:STAU1 STAU1 interactions 1.310E-6 6.325E-4 5.570E-3 4.911E-3 13 310
8 int:RPS7 RPS7 interactions 1.350E-6 6.325E-4 5.570E-3 5.060E-3 10 173
9 int:HARS HARS interactions 2.874E-6 1.197E-3 1.054E-2 1.078E-2 6 50
10 int:UBL4A UBL4A interactions 5.177E-6 1.937E-3 1.706E-2 1.941E-2 12 298
11 int:QARS QARS interactions 5.954E-6 1.937E-3 1.706E-2 2.232E-2 8 121
12 int:SIRT7 SIRT7 interactions 6.199E-6 1.937E-3 1.706E-2 2.324E-2 18 664
13 int:CDK2 CDK2 interactions 7.013E-6 2.023E-3 1.781E-2 2.629E-2 18 670
14 int:PARK2 PARK2 interactions 7.753E-6 2.076E-3 1.828E-2 2.907E-2 14 422
15 int:CAND1 CAND1 interactions 1.132E-5 2.572E-3 2.265E-2 4.245E-2 18 694
16 int:RPL26 RPL26 interactions 1.141E-5 2.572E-3 2.265E-2 4.277E-2 7 95
17 int:HIST1H3A HIST1H3A interactions 1.166E-5 2.572E-3 2.265E-2 4.373E-2 11 270
18 int:NPLOC4 NPLOC4 interactions 1.309E-5 2.726E-3 2.400E-2 4.906E-2 7 97
19 int:EEF1A1 EEF1A1 interactions 1.628E-5 3.213E-3 2.830E-2
6.105E-2
 13 391
20 int:CUL7 CUL7 interactions 1.718E-5 3.220E-3 2.836E-2
6.440E-2
 17 647
21 int:HNRNPU HNRNPU interactions 1.822E-5 3.252E-3 2.864E-2
6.830E-2
 15 518
22 int:DDX18 DDX18 interactions 1.939E-5 3.305E-3 2.910E-2
7.271E-2
 7 103
23 int:PAN2 PAN2 interactions 2.185E-5 3.420E-3 3.012E-2
8.192E-2
 12 344
24 int:DCUN1D1 DCUN1D1 interactions 2.190E-5 3.420E-3 3.012E-2
8.209E-2
 10 237
25 int:NPM1 NPM1 interactions 2.340E-5 3.509E-3 3.090E-2
8.771E-2
 16 595
26 int:CUL1 CUL1 interactions 3.292E-5 4.747E-3 4.181E-2
1.234E-1
 17 681
27 int:HIST1H4A HIST1H4A interactions 3.458E-5 4.802E-3 4.229E-2
1.297E-1
 8 154
28 int:MCM2 MCM2 interactions 3.849E-5 5.153E-3 4.538E-2
1.443E-1
 20 909
29 int:RPL32 RPL32 interactions 5.880E-5 7.602E-3
6.695E-2
2.205E-1
 6 84
30 int:RPS19 RPS19 interactions 6.689E-5 8.359E-3
7.361E-2
2.508E-1
 8 169
31 int:AARS AARS interactions 7.198E-5 8.433E-3
7.426E-2
2.698E-1
 5 54
32 int:PRPF4B PRPF4B interactions 7.198E-5 8.433E-3
7.426E-2
2.698E-1
 5 54
33 int:PSMA3 PSMA3 interactions 7.929E-5 9.008E-3
7.933E-2
2.973E-1
 10 276
34 int:NARS NARS interactions 8.583E-5 9.464E-3
8.334E-2
3.218E-1
 5 56
35 int:RPL10 RPL10 interactions 8.835E-5 9.464E-3
8.334E-2
3.312E-1
 11 337
36 int:GARS GARS interactions 9.788E-5 1.019E-2
8.977E-2
3.670E-1
 6 92
37 int:RPA1 RPA1 interactions 1.077E-4 1.091E-2
9.608E-2
4.037E-1
 13 470
38 int:DCP2 DCP2 interactions 1.196E-4 1.108E-2
9.754E-2
4.484E-1
 5 60
39 int:SNRNP70 SNRNP70 interactions 1.201E-4 1.108E-2
9.754E-2
4.502E-1
 7 137
40 int:RPL8 RPL8 interactions 1.211E-4 1.108E-2
9.754E-2
4.541E-1
 8 184
41 int:UPF2 UPF2 interactions 1.240E-4 1.108E-2
9.754E-2
4.647E-1
 6 96
42 int:HDAC5 HDAC5 interactions 1.266E-4 1.108E-2
9.754E-2
4.745E-1
 11 351
43 int:ACAT1 ACAT1 interactions 1.294E-4 1.108E-2
9.754E-2
4.853E-1
 5 61
44 int:OBSL1 OBSL1 interactions 1.300E-4 1.108E-2
9.754E-2
4.873E-1
 15 616
45 int:RPL4 RPL4 interactions 1.457E-4 1.196E-2
1.054E-1
5.464E-1
 8 189
46 int:U2AF2 U2AF2 interactions 1.468E-4 1.196E-2
1.054E-1
5.504E-1
 11 357
47 int:RPS23 RPS23 interactions 1.709E-4 1.337E-2
1.178E-1
6.408E-1
 7 145
48 int:TARDBP TARDBP interactions 1.751E-4 1.337E-2
1.178E-1
6.564E-1
 10 304
49 int:MAP4 MAP4 interactions 1.752E-4 1.337E-2
1.178E-1
6.567E-1
 5 65
50 int:RPS24 RPS24 interactions 1.783E-4 1.337E-2
1.178E-1
6.686E-1
 7 146
Show 45 more annotations

10: Cytoband [Display Chart] 101 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22q11.21 22q11.21 1.509E-9 1.524E-7 7.921E-7 1.524E-7 9 122
2 12q24.2 12q24.2 3.258E-5 1.645E-3 8.550E-3 3.290E-3 3 16
3 6p21.3 6p21.3 5.732E-4 1.930E-2
1.003E-1
5.789E-2
 6 257
4 7p15 7p15 1.795E-3 4.532E-2
2.355E-1
1.813E-1
 2 16

11: Transcription Factor Binding Site [Display Chart] 422 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F Q6 V$E2F Q6 3.911E-5 1.651E-2
1.093E-1
 1.651E-2 9 182
2 V$E2F1 Q6 V$E2F1 Q6 2.337E-4 2.204E-2
1.460E-1
9.861E-2
 8 181
3 V$E2F 02 V$E2F 02 2.613E-4 2.204E-2
1.460E-1
1.103E-1
 8 184
4 V$E2F Q4 V$E2F Q4 2.613E-4 2.204E-2
1.460E-1
1.103E-1
 8 184
5 V$E2F1 Q6 01 V$E2F1 Q6 01 3.134E-4 2.204E-2
1.460E-1
1.323E-1
 8 189
6 V$E2F4DP1 01 V$E2F4DP1 01 3.134E-4 2.204E-2
1.460E-1
1.323E-1
 8 189
7 CCCNNNNNNAAGWT UNKNOWN CCCNNNNNNAAGWT UNKNOWN 7.011E-4 4.226E-2
2.799E-1
2.959E-1
 5 78
Show 2 more annotations

12: Gene Family [Display Chart] 17 annotations before applied cutoff / 6751 genes in category

No results to display

13: Coexpression [Display Chart] 5469 annotations before applied cutoff / 21867 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19666 Genes down-regulated in Caco-2 cells (intestinal epithelium) after coculture with the probiotic bacteria L. casei for 24h. MSigDB C2: CGP Curated Gene Sets (v5.1) 8.806E-10 4.816E-6 4.423E-5 4.816E-6 13 214
2 M7300 Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.556E-9 8.451E-6 7.761E-5 2.492E-5 13 245
3 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v5.1) 4.636E-9 8.451E-6 7.761E-5 2.535E-5 12 200
4 M4772 Genes up-regulated in robust Cluster 2 (rC2) of hepatoblastoma samples compared to those in the robust Cluster 1 (rC1). MSigDB C2: CGP Curated Gene Sets (v5.1) 7.030E-9 9.611E-6 8.827E-5 3.844E-5 19 605
5 M11197 Housekeeping genes identified as expressed across 19 normal tissues. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.500E-7 1.641E-4 1.507E-3 8.204E-4 14 389
6 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.275E-6 1.162E-3 1.067E-2 6.971E-3 12 335
7 M7623 Genes down-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.527E-6 1.193E-3 1.096E-2 8.354E-3 11 281
8 M6890 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v5.1) 2.144E-6 1.466E-3 1.346E-2 1.172E-2 11 291
9 M8244 Genes changed in INA-6 cells (multiple myeloma, MM) by re-addition of IL6 [GeneID=3569] after its initial withdrawal for 12h. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.367E-6 1.976E-3 1.815E-2 1.841E-2 8 144
10 M6129 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 [GeneID=7040] and IL-12 (48h) versus IL4 [GeneID=3565] (48h). MSigDB C7: Immunologic Signatures (v5.1) 3.743E-6 1.976E-3 1.815E-2 2.047E-2 9 195
11 M1865 Up-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.975E-6 1.976E-3 1.815E-2 2.174E-2 12 374
12 M4638 Genes down-regulated in comparison of CD25- T cells treated with IL4 [GeneID=3565] at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v5.1) 4.602E-6 2.042E-3 1.876E-2 2.517E-2 9 200
13 M2099 Genes down-regulated in NB4 cells (acute promyelocytic leukemia, APL) in response to tretinoin [PubChem=444795]; based on Chip-seq data. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.855E-6 2.042E-3 1.876E-2 2.655E-2 18 841
14 M17954 Genes down-regulated in hyppocampus of mice carrying a hemizygotic microdeletion in the 22q11.2 region. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.419E-6 2.397E-3 2.201E-2 3.511E-2 4 20
15 M5922 Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. MSigDB H: Hallmark Gene Sets (v5.1) 6.880E-6 2.397E-3 2.201E-2 3.763E-2 7 113
16 M5075 Cluster 7: genes up-regulated in B493-6 cells (B lymphocytes) by MYC [GeneID=4609] and down-regulated by the combination of MYC and serum. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.013E-6 2.397E-3 2.201E-2 3.835E-2 8 159
17 M14524 Up-regulated genes in colon carcinoma tumors compared to the matched normal mucosa samples. MSigDB C2: CGP Curated Gene Sets (v5.1) 7.725E-6 2.485E-3 2.282E-2 4.225E-2 18 870
18 M18562 Genes down-regulated in response to both hypoxia and overexpression of an active form of HIF1A [GeneID=3091]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.367E-5 4.155E-3 3.816E-2
7.479E-2
 10 289
19 GSE37532 WT VS PPARG KO LN TCONV DN Genes down-regulated in T conv from lymph node of elderly (retired breeder) mice: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 1.473E-5 4.239E-3 3.893E-2
8.053E-2
 8 176
20 M6562 Genes up-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.614E-5 4.404E-3 4.045E-2
8.825E-2
 5 51
21 M19988 Genes down-regulated in metastatic breast cancer tumors having type 2 amplification in the 20q13 region; involves MYBL2, STK6 and ZNF217 [GeneID=4605;6790;7764] MSigDB C2: CGP Curated Gene Sets (v5.1) 1.733E-5 4.404E-3 4.045E-2
9.476E-2
 8 180
22 M4665 Genes down-regulated in glomeruli of kidneys from patients with diabetic nephropathy (type 2 diabetes mellitus). MSigDB C2: CGP Curated Gene Sets (v5.1) 1.772E-5 4.404E-3 4.045E-2
9.689E-2
 12 434
23 GSE46242 TH1 VS ANERGIC TH1 CD4 TCELL WITH EGR2 DELETED DN Genes down-regulated in CD4 [GeneID=920] Th1 cells with EGR2 [GeneID=1959] knockout: control versus anergic. MSigDB C7: Immunologic Signatures (v5.1) 2.860E-5 5.306E-3 4.873E-2
1.564E-1
 8 193
24 M10633 Genes which comprise the top 1% of highly interconnected genes (major hubs) that account for most of gene interactions in the reconstructed regulatory networks from expression profiles in B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.190E-5 5.306E-3 4.873E-2
1.745E-1
 7 143
25 M12113 Genes whose promoters contain E-box motifs and whose expression changed in MYCN-3 cells (neuroblastoma) upon induction of MYCN [GeneID=4613]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.534E-5 5.306E-3 4.873E-2
1.933E-1
 16 794
26 M3347 Genes down-regulated in comparison of dendritic cells (DC) before and 4 h after LPS (TLR4 agonist) stimulation. MSigDB C7: Immunologic Signatures (v5.1) 3.558E-5 5.306E-3 4.873E-2
1.946E-1
 8 199
27 GSE42724 NAIVE BCELL VS PLASMABLAST UP Genes up-regulated in B lymphocytes: naïve versus plasmablasts. MSigDB C7: Immunologic Signatures (v5.1) 3.558E-5 5.306E-3 4.873E-2
1.946E-1
 8 199
28 M5170 Genes up-regulated in comparison of macrophages versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v5.1) 3.558E-5 5.306E-3 4.873E-2
1.946E-1
 8 199
29 GSE25123 WT VS PPARG KO MACROPHAGE DN Genes down-regulated in bone marrow-derived macrophages: wildtype versus PPARG [GeneID=5468] knockout. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
30 GSE16385 MONOCYTE VS 12H ROSIGLITAZONE TREATED MACROPHAGE DN Genes down-regulated in monocytes (12h) versus macrophages (12h) treated with rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
31 GSE22140 GERMFREE VS SPF MOUSE CD4 TCELL UP Genes up-regulated in healthy CD4 [GeneID=920] T cells: germ free versus specific pathogen free. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
32 GSE21927 BALBC VS C57BL6 MONOCYTE TUMOR UP Genes up-regulated in CD11b Tumor from BALBc mouse versus CD11b Tumor from C57BL6 mouse. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
33 M4604 Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
34 M3947 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
35 M5101 Genes down-regulated in comparison of untreated CD8+ dendritic cells (DC) at 16 h versus those treated with IFNG [GeneID=31658] at 16 h. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
36 M5535 Genes down-regulated in comparison of neutrophils versus Th2 cells. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
37 GSE23925 DARK ZONE VS NAIVE BCELL UP Genes up-regulated in B cells: dark zone versus naïve. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
38 GSE37533 PPARG1 FOXP3 VS PPARG2 FOXP3 TRANSDUCED CD4 TCELL PIOGLITAZONE TREATED DN Genes down-regulated in CD4 [GeneID=920] T cells treated with pioglitazone [PubChem=4829] and over-expressing: FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468]. MSigDB C7: Immunologic Signatures (v5.1) 3.687E-5 5.306E-3 4.873E-2
2.016E-1
 8 200
39 M1410 Cluster 4: genes down-regulated in B493-6 cells (B lymphocytes) upon serum stimulation but not affected by MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v5.1) 3.808E-5 5.340E-3 4.904E-2
2.083E-1
 15 712
40 M1345 Genes commonly up-regulated in cancer relative to normal tissue, according to the meta-analysis of the OncoMine gene expression database. MSigDB C2: CGP Curated Gene Sets (v5.1) 4.909E-5 6.712E-3
6.164E-2
2.685E-1
 5 64
41 M3185 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. MSigDB C2: CGP Curated Gene Sets (v5.1) 5.034E-5 6.715E-3
6.167E-2
2.753E-1
 6 105
42 M9221 Genes up-regulated in primary fibroblast culture after treatment with interferon alpha for 6 h. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.579E-5 8.549E-3
7.851E-2
3.598E-1
 5 68
43 M18635 Genes down-regulated in APL (acute promyeolocytic leukemia) blasts expressing PML-RARA fusion [GeneID=5371;5914] compared to normal promyeloblasts. MSigDB C2: CGP Curated Gene Sets (v5.1) 6.722E-5 8.549E-3
7.851E-2
3.676E-1
 14 662
44 M6769 Genes down-regulated in cells from Flt3L Melanom injected mice: splenic DEC205+ dendritic cells versus CD8 T cells. MSigDB C7: Immunologic Signatures (v5.1) 8.538E-5 1.061E-2
9.747E-2
4.670E-1
 7 167
45 M1107 Genes down-regulated in ME-A cells (breast cancer, sensitive to apoptotic stimuli) exposed to doxorubicin [PubChem=31703] in the presence of medium concentrate (MC) from ME-C cells (breast cancer, resistant to apoptotic stimuli). MSigDB C2: CGP Curated Gene Sets (v5.1) 9.184E-5 1.099E-2
1.010E-1
5.023E-1
 15 770
46 M11516 Selected genes changed in K562 (immortalized erythroleukemia) cells induced by hemin [PubChem=26945] treatment to express erythroid properties. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.248E-5 1.099E-2
1.010E-1
5.058E-1
 5 73
47 M17753 Set 'Myc targets2': targets of c-Myc [GeneID=4609] and Max [GeneID=4149] identified by ChIP on chip in a Burkitt's lymphoma cell line; overlap set. MSigDB C2: CGP Curated Gene Sets (v5.1) 9.866E-5 1.148E-2
1.054E-1
5.396E-1
 15 775
48 M6882 Genes up-regulated in monocytes after HCMV infection: untreated versus Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v5.1) 1.104E-4 1.257E-2
1.155E-1
6.036E-1
 7 174
49 M2314 Genes down-regulated in DL23 cells (colon cancer) upon expression of an activated form of FOXO3 [GeneID=2309]. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.213E-4 1.353E-2
1.243E-1
6.632E-1
 4 41
50 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v5.1) 1.282E-4 1.402E-2
1.288E-1
7.012E-1
 8 239
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 2064 annotations before applied cutoff / 20974 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 JC iEC 2500 K5 JC iEC top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 2.481E-6 5.120E-3 4.203E-2 5.120E-3 18 763
2 gudmap developingKidney e12.5 renal vesicle 1000 k1 DevelopingKidney e12.5 renal vesicle emap-27679 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.716E-5 1.771E-2
1.454E-1
 3.541E-2 12 412

15: Computational [Display Chart] 431 annotations before applied cutoff / 9399 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 module 110 Genes in module 110 MSigDb: C4 - CM: Cancer Modules 2.238E-7 3.216E-5 2.137E-4 9.647E-5 5 15
2 module 133 Genes in module 133 MSigDb: C4 - CM: Cancer Modules 2.238E-7 3.216E-5 2.137E-4 9.647E-5 5 15
3 module 160 Genes in module 160 MSigDb: C4 - CM: Cancer Modules 2.238E-7 3.216E-5 2.137E-4 9.647E-5 5 15
4 module 35 Genes in module 35 MSigDb: C4 - CM: Cancer Modules 3.231E-7 3.481E-5 2.313E-4 1.392E-4 5 16
5 MORF HDAC2 Neighborhood of HDAC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.346E-5 3.746E-3 2.489E-2 1.873E-2 11 260
6 MORF BUB1 Neighborhood of BUB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.205E-4 8.659E-3
5.753E-2
5.195E-2
 5 50
7 MORF BUB3 Neighborhood of BUB3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 2.163E-4 1.332E-2
8.848E-2
9.321E-2
 10 260
8 MORF RAD54L Neighborhood of RAD54L MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.043E-4 1.640E-2
1.089E-1
1.312E-1
 6 94
9 MORF EI24 Neighborhood of EI24 MSigDb: C4 - CGN: Cancer Gene Neighborhood 3.916E-4 1.671E-2
1.110E-1
1.688E-1
 7 138
10 MORF RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.091E-4 1.671E-2
1.110E-1
1.763E-1
 7 139
11 module 32 Genes in module 32 MSigDb: C4 - CM: Cancer Modules 4.265E-4 1.671E-2
1.110E-1
1.838E-1
 9 232
12 GNF2 DAP3 Neighborhood of DAP3 MSigDb: C4 - CGN: Cancer Gene Neighborhood 4.981E-4 1.789E-2
1.189E-1
2.147E-1
 6 103
13 GNF2 EIF3S6 Neighborhood of EIF3S6 MSigDb: C4 - CGN: Cancer Gene Neighborhood 7.065E-4 2.342E-2
1.556E-1
3.045E-1
 6 110
14 MORF RAD23A Neighborhood of RAD23A MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.103E-3 3.287E-2
2.184E-1
4.754E-1
 10 320
15 MORF XRCC5 Neighborhood of XRCC5 MSigDb: C4 - CGN: Cancer Gene Neighborhood 1.144E-3 3.287E-2
2.184E-1
4.930E-1
 8 214
Show 10 more annotations

16: MicroRNA [Display Chart] 1834 annotations before applied cutoff / 19844 genes in category

No results to display

17: Drug [Display Chart] 15072 annotations before applied cutoff / 22098 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 D015655 1-Methyl-4-phenylpyridinium CTD 4.251E-8 6.407E-4 6.534E-3 6.407E-4 20 753
2 C517041 (4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) CTD 2.264E-7 1.706E-3 1.740E-2 3.412E-3 15 468
3 C059262 cidofovir CTD 1.120E-6 4.891E-3 4.988E-2 1.689E-2 11 273
4 1916 UP Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HG-U133A Broad Institute CMAP 1.298E-6 4.891E-3 4.988E-2 1.956E-2 9 172
5 5962 UP valinomycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP 1.807E-6 5.209E-3
5.312E-2
 2.724E-2 9 179
6 6427 UP STOCK1N-35215; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 2.073E-6 5.209E-3
5.312E-2
 3.125E-2 9 182
7 612 UP cox-2 inhibitor I; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP 2.954E-6 5.487E-3
5.596E-2
 4.453E-2 9 190
8 CID000446806 3,6-anhydro-D-galactose 2-sulfate Stitch 3.112E-6 5.487E-3
5.596E-2
 4.690E-2 6 65
9 C004656 chloroacetaldehyde CTD 3.277E-6 5.487E-3
5.596E-2
 4.939E-2 11 305
10 543 DN 1,5-Isoquinolinediol; Down 200; 100uM; HL60; HG-U133A Broad Institute CMAP 3.655E-6 5.508E-3
5.617E-2
5.508E-2
 9 195
11 1893 DN Doxylamine succinate [562-10-7]; Down 200; 10.2uM; PC3; HG-U133A Broad Institute CMAP 4.140E-6 5.672E-3
5.784E-2
6.239E-2
 9 198
12 D008687 Metformin CTD 5.609E-6 6.864E-3
6.999E-2
8.453E-2
 12 388
13 D002065 Buspirone CTD 5.920E-6 6.864E-3
6.999E-2
8.923E-2
 15 609
14 CID000068290 valyl Stitch 7.210E-6 7.762E-3
7.916E-2
1.087E-1
 6 75
15 979 UP ionomycin calcium salt; Up 200; 2uM; MCF7; HT HG-U133A EA Broad Institute CMAP 9.005E-6 9.048E-3
9.227E-2
1.357E-1
 8 165
16 941 UP rottlerin; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP 1.120E-5 9.707E-3
9.899E-2
1.688E-1
 8 170
17 1656 UP 15d-PGJ2; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 1.120E-5 9.707E-3
9.899E-2
1.688E-1
 8 170
18 D013759 Dronabinol CTD 1.159E-5 9.707E-3
9.899E-2
1.747E-1
 18 899
19 CID000001023 pyrophosphate Stitch 1.378E-5 1.078E-2
1.099E-1
2.078E-1
 15 654
20 C515564 bromovanin CTD 1.453E-5 1.078E-2
1.099E-1
2.189E-1
 7 127
21 5306 UP Propofol [2078-54-8]; Up 200; 22.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.696E-5 1.078E-2
1.099E-1
2.556E-1
 8 180
22 6205 UP Mefloquine hydrochloride [51773-92-3]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP 1.837E-5 1.078E-2
1.099E-1
2.768E-1
 8 182
23 C061133 tamibarotene CTD 1.973E-5 1.078E-2
1.099E-1
2.974E-1
 14 593
24 3190 UP Fendiline hydrochloride [13636-18-5]; Up 200; 11.4uM; MCF7; HT HG-U133A Broad Institute CMAP 1.987E-5 1.078E-2
1.099E-1
2.995E-1
 8 184
25 D004002 Clodronic Acid CTD 2.006E-5 1.078E-2
1.099E-1
3.023E-1
 9 241
26 1563 DN Quinacrine dihydrochloride dihydrate [6151-30-0]; Down 200; 7.8uM; HL60; HG-U133A Broad Institute CMAP 2.148E-5 1.078E-2
1.099E-1
3.238E-1
 8 186
27 C063855 microcystin RR CTD 2.201E-5 1.078E-2
1.099E-1
3.317E-1
 6 91
28 D007069 Ifosfamide CTD 2.284E-5 1.078E-2
1.099E-1
3.443E-1
 9 245
29 2619 UP Thioguanosine [85-31-4]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP 2.503E-5 1.078E-2
1.099E-1
3.772E-1
 8 190
30 D011345 Fenofibrate CTD 2.505E-5 1.078E-2
1.099E-1
3.776E-1
 14 606
31 6574 UP 5155877; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP 2.698E-5 1.078E-2
1.099E-1
4.066E-1
 8 192
32 6207 UP Clotrimazole [23593-75-1]; Up 200; 11.6uM; MCF7; HT HG-U133A Broad Institute CMAP 2.800E-5 1.078E-2
1.099E-1
4.220E-1
 8 193
33 2101 DN Tranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; PC3; HT HG-U133A Broad Institute CMAP 2.800E-5 1.078E-2
1.099E-1
4.220E-1
 8 193
34 7132 UP Pimozide [2062-78-4]; Up 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP 2.905E-5 1.078E-2
1.099E-1
4.379E-1
 8 194
35 1147 DN 17-AAG; Down 200; 1uM; HL60; HT HG-U133A Broad Institute CMAP 2.905E-5 1.078E-2
1.099E-1
4.379E-1
 8 194
36 6915 DN SB 203580; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP 2.905E-5 1.078E-2
1.099E-1
4.379E-1
 8 194
37 544 DN radicicol; Down 200; 0.1uM; HL60; HG-U133A Broad Institute CMAP 3.014E-5 1.078E-2
1.099E-1
4.542E-1
 8 195
38 4740 DN Sulfamerazine [127-79-7]; Down 200; 15.2uM; MCF7; HT HG-U133A Broad Institute CMAP 3.014E-5 1.078E-2
1.099E-1
4.542E-1
 8 195
39 2761 DN Atropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; MCF7; HT HG-U133A Broad Institute CMAP 3.014E-5 1.078E-2
1.099E-1
4.542E-1
 8 195
40 3370 DN Fluvastatin sodium salt [93957-55-2]; Down 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP 3.241E-5 1.078E-2
1.099E-1
4.885E-1
 8 197
41 1938 DN Cyproheptadine hydrochloride [969-33-5]; Down 200; 12.4uM; PC3; HG-U133A Broad Institute CMAP 3.241E-5 1.078E-2
1.099E-1
4.885E-1
 8 197
42 4415 DN Etilefrine hydrochloride [534-87-2]; Down 200; 18.4uM; MCF7; HT HG-U133A Broad Institute CMAP 3.241E-5 1.078E-2
1.099E-1
4.885E-1
 8 197
43 6801 DN Pyrithyldione [77-04-3]; Down 200; 24uM; MCF7; HT HG-U133A Broad Institute CMAP 3.360E-5 1.078E-2
1.099E-1
5.065E-1
 8 198
44 5983 UP Ozagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; MCF7; HT HG-U133A Broad Institute CMAP 3.360E-5 1.078E-2
1.099E-1
5.065E-1
 8 198
45 1203 UP haloperidol; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.360E-5 1.078E-2
1.099E-1
5.065E-1
 8 198
46 6560 UP Gly-His-Lys acetate salt; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP 3.360E-5 1.078E-2
1.099E-1
5.065E-1
 8 198
47 6426 UP 0225151-0000 [351320-15-5]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP 3.360E-5 1.078E-2
1.099E-1
5.065E-1
 8 198
48 C103505 AM 251 CTD 3.553E-5 1.116E-2
1.138E-1
5.355E-1
 6 99
49 CID005460671 pyrrolysine Stitch 4.923E-5 1.514E-2
1.544E-1
7.420E-1
 3 12
50 D002922 Ciguatoxins CTD 5.234E-5 1.578E-2
1.609E-1
7.889E-1
 16 823
Show 45 more annotations

18: Disease [Display Chart] 1114 annotations before applied cutoff / 16150 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 umls:C0220704 Shprintzen syndrome DisGeNET Curated 2.884E-9 3.213E-6 2.439E-5 3.213E-6 8 56
2 umls:C0012236 DiGeorge Syndrome DisGeNET Curated 1.992E-8 1.109E-5 8.424E-5 2.219E-5 8 71
3 umls:C3266101 22q11 partial monosomy syndrome DisGeNET Curated 6.044E-8 2.244E-5 1.704E-4 6.733E-5 4 7
4 umls:C0795907 CONOTRUNCAL ANOMALY FACE SYNDROME DisGeNET Curated 9.437E-6 2.628E-3 1.996E-2 1.051E-2 3 7
5 umls:C0597647 viral leukemogenesis DisGeNET BeFree 4.295E-5 9.570E-3
7.267E-2
 4.785E-2 2 2
6 umls:C0272214 Persistent lymphocytosis DisGeNET BeFree 1.275E-4 2.113E-2
1.604E-1
1.420E-1
 2 3
7 umls:C0238288 Muscular Dystrophy, Facioscapulohumeral DisGeNET Curated 1.328E-4 2.113E-2
1.604E-1
1.479E-1
 5 75
8 umls:C0795856 Trisomy 15 DisGeNET BeFree 2.539E-4 3.535E-2
2.684E-1
2.828E-1
 2 4
9 umls:C2936346 22q11 Deletion Syndrome DisGeNET Curated 2.888E-4 3.575E-2
2.715E-1
3.218E-1
 3 20
Show 4 more annotations