Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc101_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 69 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019789 SUMO transferase activity 1.184E-7 8.171E-6 3.937E-5 8.171E-6 3 25
2 GO:0051718 DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates 4.824E-7 1.664E-5 8.019E-5 3.328E-5 2 3
3 GO:0003886 DNA (cytosine-5-)-methyltransferase activity 9.645E-7 2.218E-5 1.069E-4 6.655E-5 2 4
4 GO:0061665 SUMO ligase activity 1.607E-6 2.772E-5 1.336E-4 1.109E-4 2 5
5 GO:0045322 unmethylated CpG binding 4.497E-6 6.206E-5 2.990E-4 3.103E-4 2 8
6 GO:0035258 steroid hormone receptor binding 5.772E-6 6.638E-5 3.198E-4 3.983E-4 3 89
7 GO:0035257 nuclear hormone receptor binding 3.420E-5 3.371E-4 1.624E-3 2.360E-3 3 161
8 GO:0008757 S-adenosylmethionine-dependent methyltransferase activity 4.849E-5 3.512E-4 1.692E-3 3.346E-3 3 181
9 GO:0051427 hormone receptor binding 5.011E-5 3.512E-4 1.692E-3 3.457E-3 3 183
10 GO:0008168 methyltransferase activity 7.872E-5 3.512E-4 1.692E-3 5.431E-3 3 213
11 GO:0061659 ubiquitin-like protein ligase activity 8.319E-5 3.512E-4 1.692E-3 5.740E-3 3 217
12 GO:0008022 protein C-terminus binding 9.141E-5 3.512E-4 1.692E-3 6.307E-3 3 224
13 GO:0016741 transferase activity, transferring one-carbon groups 9.263E-5 3.512E-4 1.692E-3 6.391E-3 3 225
14 GO:0003714 transcription corepressor activity 1.054E-4 3.512E-4 1.692E-3 7.271E-3 3 235
15 GO:0070735 protein-glycine ligase activity 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
16 GO:0043773 coenzyme F420-0 gamma-glutamyl ligase activity 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
17 GO:0070737 protein-glycine ligase activity, elongating 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
18 GO:0043774 coenzyme F420-2 alpha-glutamyl ligase activity 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
19 GO:0070738 tubulin-glycine ligase activity 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
20 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
21 GO:0070736 protein-glycine ligase activity, initiating 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
22 GO:0018169 ribosomal S6-glutamic acid ligase activity 1.150E-4 3.512E-4 1.692E-3 7.932E-3 3 242
23 GO:0070740 tubulin-glutamic acid ligase activity 1.192E-4 3.512E-4 1.692E-3 8.227E-3 3 245
24 GO:0070739 protein-glutamic acid ligase activity 1.221E-4 3.512E-4 1.692E-3 8.428E-3 3 247
25 GO:0050681 androgen receptor binding 1.308E-4 3.609E-4 1.739E-3 9.023E-3 2 41
26 GO:0016881 acid-amino acid ligase activity 1.374E-4 3.646E-4 1.757E-3 9.479E-3 3 257
27 GO:0031625 ubiquitin protein ligase binding 1.642E-4 4.097E-4 1.974E-3 1.133E-2 3 273
28 GO:0044389 ubiquitin-like protein ligase binding 1.715E-4 4.097E-4 1.974E-3 1.183E-2 3 277
29 GO:0030331 estrogen receptor binding 1.722E-4 4.097E-4 1.974E-3 1.188E-2 2 47
30 GO:0016879 ligase activity, forming carbon-nitrogen bonds 2.024E-4 4.655E-4 2.243E-3 1.396E-2 3 293
31 GO:0043035 chromatin insulator sequence binding 4.287E-4 9.244E-4 4.454E-3 2.958E-2 1 1
32 GO:0061656 SUMO conjugating enzyme activity 4.287E-4 9.244E-4 4.454E-3 2.958E-2 1 1
33 GO:0009008 DNA-methyltransferase activity 5.508E-4 1.142E-3 5.502E-3 3.801E-2 2 84
34 GO:0016874 ligase activity 5.627E-4 1.142E-3 5.502E-3 3.883E-2 3 415
35 GO:0019787 ubiquitin-like protein transferase activity 6.719E-4 1.325E-3 6.383E-3 4.636E-2 3 441
36 GO:0042826 histone deacetylase binding 1.011E-3 1.938E-3 9.339E-3
6.978E-2
 2 114
37 GO:0043398 HLH domain binding 1.286E-3 2.398E-3 1.155E-2
8.871E-2
 1 3
38 GO:0071535 RING-like zinc finger domain binding 1.714E-3 3.112E-3 1.500E-2
1.183E-1
 1 4
39 GO:0046974 histone methyltransferase activity (H3-K9 specific) 2.570E-3 4.433E-3 2.136E-2
1.773E-1
 1 6
40 GO:0031749 D2 dopamine receptor binding 2.570E-3 4.433E-3 2.136E-2
1.773E-1
 1 6
41 GO:0003713 transcription coactivator activity 7.209E-3 1.194E-2
5.752E-2
4.974E-1
 2 310
42 GO:1990841 promoter-specific chromatin binding 7.266E-3 1.194E-2
5.752E-2
5.014E-1
 1 17
43 GO:0035259 glucocorticoid receptor binding 8.118E-3 1.303E-2
6.277E-2
5.601E-1
 1 19
44 GO:0008327 methyl-CpG binding 9.394E-3 1.409E-2
6.790E-2
6.482E-1
 1 22
45 GO:0050998 nitric-oxide synthase binding 9.394E-3 1.409E-2
6.790E-2
6.482E-1
 1 22
46 GO:0050780 dopamine receptor binding 9.394E-3 1.409E-2
6.790E-2
6.482E-1
 1 22
47 GO:0043425 bHLH transcription factor binding 1.279E-2 1.878E-2
9.049E-2
8.826E-1
 1 30
48 GO:0061650 ubiquitin-like protein conjugating enzyme activity 1.364E-2 1.961E-2
9.447E-2
9.411E-1
 1 32
49 GO:0018024 histone-lysine N-methyltransferase activity 1.955E-2 2.754E-2
1.327E-1
1.000E0
 1 46
50 GO:0042054 histone methyltransferase activity 2.502E-2 3.453E-2
1.664E-1
1.000E0
 1 59
Show 45 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 294 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0018205 peptidyl-lysine modification 2.449E-11 7.199E-9 4.509E-8 7.199E-9 7 426
2 GO:0016571 histone methylation 1.862E-7 2.737E-5 1.714E-4 5.474E-5 4 136
3 GO:0051567 histone H3-K9 methylation 2.822E-7 2.765E-5 1.732E-4 8.296E-5 3 33
4 GO:0008213 protein alkylation 5.005E-7 2.943E-5 1.843E-4 1.472E-4 4 174
5 GO:0006479 protein methylation 5.005E-7 2.943E-5 1.843E-4 1.472E-4 4 174
6 GO:0061647 histone H3-K9 modification 7.830E-7 3.837E-5 2.403E-4 2.302E-4 3 46
7 GO:0090116 C-5 methylation of cytosine 9.684E-7 4.067E-5 2.547E-4 2.847E-4 2 4
8 GO:0046499 S-adenosylmethioninamine metabolic process 1.614E-6 5.272E-5 3.301E-4 4.744E-4 2 5
9 GO:0010424 DNA methylation on cytosine within a CG sequence 1.614E-6 5.272E-5 3.301E-4 4.744E-4 2 5
10 GO:0031060 regulation of histone methylation 2.041E-6 5.565E-5 3.485E-4 6.002E-4 3 63
11 GO:0032776 DNA methylation on cytosine 2.420E-6 5.565E-5 3.485E-4 7.115E-4 2 6
12 GO:0006306 DNA methylation 2.461E-6 5.565E-5 3.485E-4 7.234E-4 3 67
13 GO:0006305 DNA alkylation 2.461E-6 5.565E-5 3.485E-4 7.234E-4 3 67
14 GO:0040029 regulation of gene expression, epigenetic 2.683E-6 5.634E-5 3.528E-4 7.887E-4 4 265
15 GO:0043414 macromolecule methylation 3.019E-6 5.918E-5 3.706E-4 8.877E-4 4 273
16 GO:0010216 maintenance of DNA methylation 3.387E-6 6.224E-5 3.898E-4 9.959E-4 2 7
17 GO:0071383 cellular response to steroid hormone stimulus 3.838E-6 6.638E-5 4.157E-4 1.128E-3 4 290
18 GO:0044728 DNA methylation or demethylation 4.370E-6 6.638E-5 4.157E-4 1.285E-3 3 81
19 GO:0043045 DNA methylation involved in embryo development 4.516E-6 6.638E-5 4.157E-4 1.328E-3 2 8
20 GO:1901538 changes to DNA methylation involved in embryo development 4.516E-6 6.638E-5 4.157E-4 1.328E-3 2 8
21 GO:0009048 dosage compensation by inactivation of X chromosome 5.804E-6 8.126E-5 5.089E-4 1.707E-3 2 9
22 GO:0032259 methylation 7.997E-6 1.069E-4 6.693E-4 2.351E-3 4 349
23 GO:0006304 DNA modification 8.501E-6 1.086E-4 6.800E-4 2.499E-3 3 101
24 GO:0007549 dosage compensation 8.864E-6 1.086E-4 6.800E-4 2.606E-3 2 11
25 GO:0051573 negative regulation of histone H3-K9 methylation 1.063E-5 1.209E-4 7.571E-4 3.127E-3 2 12
26 GO:0034968 histone lysine methylation 1.069E-5 1.209E-4 7.571E-4 3.143E-3 3 109
27 GO:0046498 S-adenosylhomocysteine metabolic process 1.257E-5 1.368E-4 8.569E-4 3.694E-3 2 13
28 GO:0018022 peptidyl-lysine methylation 1.392E-5 1.461E-4 9.152E-4 4.092E-3 3 119
29 GO:0006342 chromatin silencing 1.500E-5 1.520E-4 9.521E-4 4.409E-3 3 122
30 GO:0033235 positive regulation of protein sumoylation 1.691E-5 1.657E-4 1.038E-3 4.971E-3 2 15
31 GO:0030518 intracellular steroid hormone receptor signaling pathway 2.077E-5 1.892E-4 1.185E-3 6.106E-3 3 136
32 GO:0045814 negative regulation of gene expression, epigenetic 2.123E-5 1.892E-4 1.185E-3 6.242E-3 3 137
33 GO:0016570 histone modification 2.124E-5 1.892E-4 1.185E-3 6.243E-3 4 447
34 GO:0051571 positive regulation of histone H3-K4 methylation 2.189E-5 1.893E-4 1.185E-3 6.436E-3 2 17
35 GO:0016925 protein sumoylation 2.265E-5 1.903E-4 1.192E-3 6.660E-3 3 140
36 GO:0016569 covalent chromatin modification 2.418E-5 1.947E-4 1.219E-3 7.109E-3 4 462
37 GO:0006349 regulation of gene expression by genetic imprinting 2.462E-5 1.947E-4 1.219E-3 7.239E-3 2 18
38 GO:0031056 regulation of histone modification 2.516E-5 1.947E-4 1.219E-3 7.397E-3 3 145
39 GO:0031061 negative regulation of histone methylation 3.056E-5 2.304E-4 1.443E-3 8.985E-3 2 20
40 GO:0033189 response to vitamin A 3.714E-5 2.663E-4 1.668E-3 1.092E-2 2 22
41 GO:0051570 regulation of histone H3-K9 methylation 3.714E-5 2.663E-4 1.668E-3 1.092E-2 2 22
42 GO:1902275 regulation of chromatin organization 3.906E-5 2.734E-4 1.712E-3 1.148E-2 3 168
43 GO:0006346 methylation-dependent chromatin silencing 4.436E-5 2.964E-4 1.856E-3 1.304E-2 2 24
44 GO:0031000 response to caffeine 4.436E-5 2.964E-4 1.856E-3 1.304E-2 2 24
45 GO:0033233 regulation of protein sumoylation 4.820E-5 3.149E-4 1.972E-3 1.417E-2 2 25
46 GO:0043401 steroid hormone mediated signaling pathway 5.550E-5 3.547E-4 2.221E-3 1.632E-2 3 189
47 GO:0051569 regulation of histone H3-K4 methylation 6.518E-5 3.992E-4 2.500E-3 1.916E-2 2 29
48 GO:0071514 genetic imprinting 6.518E-5 3.992E-4 2.500E-3 1.916E-2 2 29
49 GO:0009755 hormone-mediated signaling pathway 9.819E-5 5.891E-4 3.690E-3 2.887E-2 3 229
50 GO:0031062 positive regulation of histone methylation 1.067E-4 6.276E-4 3.930E-3 3.138E-2 2 37
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 34 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000775 chromosome, centromeric region 5.833E-7 1.983E-5 8.168E-5 1.983E-5 4 185
2 GO:0000792 heterochromatin 5.059E-6 6.348E-5 2.614E-4 1.720E-4 3 87
3 GO:0098687 chromosomal region 6.892E-6 6.348E-5 2.614E-4 2.343E-4 4 344
4 GO:0016605 PML body 7.469E-6 6.348E-5 2.614E-4 2.539E-4 3 99
5 GO:0000793 condensed chromosome 6.889E-5 4.684E-4 1.929E-3 2.342E-3 3 208
6 GO:0005720 nuclear heterochromatin 1.316E-4 7.458E-4 3.071E-3 4.475E-3 2 42
7 GO:0016604 nuclear body 3.602E-4 1.749E-3 7.205E-3 1.225E-2 3 364
8 GO:1990356 sumoylated E2 ligase complex 4.197E-4 1.784E-3 7.346E-3 1.427E-2 1 1
9 GO:0000794 condensed nuclear chromosome 7.035E-4 2.658E-3 1.094E-2 2.392E-2 2 97
10 GO:0000785 chromatin 8.435E-4 2.868E-3 1.181E-2 2.868E-2 3 487
11 GO:0033553 rDNA heterochromatin 1.678E-3 5.186E-3 2.136E-2
5.705E-2
 1 4
12 GO:0016607 nuclear speck 2.971E-3 8.419E-3 3.467E-2
1.010E-1
 2 201
13 GO:0005677 chromatin silencing complex 3.772E-3 9.160E-3 3.772E-2
1.282E-1
 1 9
14 GO:0001650 fibrillar center 3.772E-3 9.160E-3 3.772E-2
1.282E-1
 1 9
15 GO:0005652 nuclear lamina 5.444E-3 1.234E-2
5.082E-2
1.851E-1
 1 13
16 GO:0043196 varicosity 6.279E-3 1.334E-2
5.495E-2
2.135E-1
 1 15
17 GO:0000790 nuclear chromatin 7.537E-3 1.501E-2
6.183E-2
2.563E-1
 2 324
18 GO:0005721 pericentric heterochromatin 7.948E-3 1.501E-2
6.183E-2
2.702E-1
 1 19
19 GO:0000795 synaptonemal complex 1.625E-2 2.909E-2
1.198E-1
5.527E-1
 1 39
20 GO:0001917 photoreceptor inner segment 1.915E-2 3.255E-2
1.341E-1
6.510E-1
 1 46
21 GO:0005657 replication fork 2.778E-2 4.483E-2
1.846E-1
9.446E-1
 1 67
22 GO:0044452 nucleolar part 2.901E-2 4.483E-2
1.846E-1
9.863E-1
 1 70
23 GO:0044304 main axon 3.064E-2 4.530E-2
1.866E-1
1.000E0
 1 74
Show 18 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 166 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 8 input genes in category / 233 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0013503 abnormal embryonic tissue cell apoptosis 2.803E-4 4.685E-2
2.825E-1
6.530E-2
 3 182
2 MP:0008877 abnormal DNA methylation 6.032E-4 4.685E-2
2.825E-1
1.405E-1
 2 49
3 MP:0006386 absent somites 6.032E-4 4.685E-2
2.825E-1
1.405E-1
 2 49

6: Domain [Display Chart] 8 input genes in category / 96 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00095 C5 MTASE 2 PROSITE 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
2 PF00145 DNA methylase Pfam 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
3 PS51679 SAM MT C5 PROSITE 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
4 PS51466 PINIT PROSITE 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
5 PF14324 PINIT Pfam 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
6 IPR023321 PINIT InterPro 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
7 PS00094 C5 MTASE 1 PROSITE 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
8 IPR018117 C5 DNA meth AS InterPro 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
9 IPR001525 C5 MeTfrase InterPro 9.569E-7 1.021E-5 5.253E-5 9.186E-5 2 4
10 PF02891 zf-MIZ Pfam 3.347E-6 2.921E-5 1.503E-4 3.213E-4 2 7
11 PS51044 ZF SP RING PROSITE 3.347E-6 2.921E-5 1.503E-4 3.213E-4 2 7
12 IPR004181 Znf MIZ InterPro 4.462E-6 3.569E-5 1.837E-4 4.283E-4 2 8
13 1.10.720.30 - Gene3D 3.337E-5 2.464E-4 1.268E-3 3.204E-3 2 21
14 PF02037 SAP Pfam 3.670E-5 2.517E-4 1.295E-3 3.523E-3 2 22
15 SM00513 SAP SMART 4.019E-5 2.572E-4 1.324E-3 3.858E-3 2 23
16 IPR003034 SAP dom InterPro 4.763E-5 2.690E-4 1.384E-3 4.573E-3 2 25
17 PS50800 SAP PROSITE 4.763E-5 2.690E-4 1.384E-3 4.573E-3 2 25
18 IPR027741 DNM1 InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
19 IPR017198 DNMT1 meta InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
20 IPR027227 PIAS1 InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
21 IPR030488 DNMT3B InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
22 IPR022702 Cytosine MeTrfase1 RFD InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
23 IPR027228 PIAS2 InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
24 PF12047 DNMT1-RFD Pfam 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
25 IPR027230 Ubc9 InterPro 4.270E-4 1.640E-3 8.439E-3 4.099E-2 1 1
26 IPR011381 Histone H3-K9 MeTrfase InterPro 8.539E-4 2.928E-3 1.507E-2
8.197E-2
 1 2
27 IPR031303 C5 meth CS InterPro 8.539E-4 2.928E-3 1.507E-2
8.197E-2
 1 2
28 PS51579 SAM MT43 SUVAR39 3 PROSITE 8.539E-4 2.928E-3 1.507E-2
8.197E-2
 1 2
29 3.40.50.150 - Gene3D 1.111E-3 3.673E-3 1.890E-2
1.066E-1
 2 120
30 IPR029063 SAM-dependent MTases InterPro 1.148E-3 3.673E-3 1.890E-2
1.102E-1
 2 122
31 IPR025766 ADD InterPro 1.707E-3 5.121E-3 2.636E-2
1.639E-1
 1 4
32 PS51533 ADD PROSITE 1.707E-3 5.121E-3 2.636E-2
1.639E-1
 1 4
33 PF06464 DMAP binding Pfam 2.133E-3 5.715E-3 2.941E-2
2.048E-1
 1 5
34 IPR010506 DMAP1-bd InterPro 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
35 PF02212 GED Pfam 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
36 PF01031 Dynamin M Pfam 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
37 IPR003130 GED InterPro 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
38 PS51388 GED PROSITE 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
39 IPR020850 GED dom InterPro 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
40 SM01137 DMAP binding SMART 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
41 IPR000375 Dynamin central InterPro 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
42 IPR019762 Dynamin GTPase CS InterPro 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
43 SM00302 GED SMART 2.560E-3 5.715E-3 2.941E-2
2.457E-1
 1 6
44 PF05033 Pre-SET Pfam 2.986E-3 5.850E-3 3.011E-2
2.866E-1
 1 7
45 IPR007728 Pre-SET dom InterPro 2.986E-3 5.850E-3 3.011E-2
2.866E-1
 1 7
46 PS50867 PRE SET PROSITE 2.986E-3 5.850E-3 3.011E-2
2.866E-1
 1 7
47 SM00468 PreSET SMART 2.986E-3 5.850E-3 3.011E-2
2.866E-1
 1 7
48 SM00053 DYNc SMART 2.986E-3 5.850E-3 3.011E-2
2.866E-1
 1 7
49 PS00410 G DYNAMIN 1 PROSITE 2.986E-3 5.850E-3 3.011E-2
2.866E-1
 1 7
50 SM00439 BAH SMART 4.688E-3 8.037E-3 4.137E-2
4.501E-1
 1 11
Show 45 more annotations

7: Pathway [Display Chart] 8 input genes in category / 103 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138029 Sumoylation by RanBP2 regulates transcriptional repression BioSystems: Pathway Interaction Database 2.867E-8 2.953E-6 1.540E-5 2.953E-6 3 11
2 1339111 SUMOylation of chromatin organization proteins BioSystems: REACTOME 2.166E-6 1.116E-4 5.821E-4 2.231E-4 2 4
3 1268744 SUMOylation of DNA damage response and repair proteins BioSystems: REACTOME 1.295E-5 4.447E-4 2.320E-3 1.334E-3 3 78
4 413353 Methionine degradation BioSystems: KEGG 1.981E-5 5.102E-4 2.662E-3 2.041E-3 2 11
5 1268743 SUMO E3 ligases SUMOylate target proteins BioSystems: REACTOME 3.076E-5 5.502E-4 2.870E-3 3.168E-3 3 104
6 1268738 SUMOylation BioSystems: REACTOME 3.639E-5 5.502E-4 2.870E-3 3.748E-3 3 110
7 1269737 Negative epigenetic regulation of rRNA expression BioSystems: REACTOME 3.739E-5 5.502E-4 2.870E-3 3.851E-3 3 111
8 P00038 JAK/STAT signaling pathway PantherDB 4.316E-5 5.557E-4 2.899E-3 4.446E-3 2 16
9 1339110 SUMOylation of transcription factors BioSystems: REACTOME 4.890E-5 5.597E-4 2.920E-3 5.037E-3 2 17
10 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 7.011E-5 7.222E-4 3.767E-3 7.222E-3 3 137
11 1269734 Epigenetic regulation of gene expression BioSystems: REACTOME 9.553E-5 8.945E-4 4.666E-3 9.839E-3 3 152
12 P00035 Interferon-gamma signaling pathway PantherDB 1.354E-4 1.152E-3 6.011E-3 1.395E-2 2 28
13 PW:0000209 JAK-STAT signaling Pathway Ontology 1.454E-4 1.152E-3 6.011E-3 1.498E-2 2 29
14 1309114 Formation of Incision Complex in GG-NER BioSystems: REACTOME 3.220E-4 2.369E-3 1.236E-2 3.317E-2 2 43
15 104488 Cysteine and methionine metabolism BioSystems: KEGG 3.528E-4 2.422E-3 1.264E-2 3.634E-2 2 45
16 137916 Regulation of retinoblastoma protein BioSystems: Pathway Interaction Database 5.468E-4 3.433E-3 1.791E-2
5.632E-2
 2 56
17 138085 Coregulation of Androgen receptor activity BioSystems: Pathway Interaction Database 5.665E-4 3.433E-3 1.791E-2
5.835E-2
 2 57
18 852705 MicroRNAs in cancer BioSystems: KEGG 7.022E-4 4.018E-3 2.096E-2
7.232E-2
 3 299
19 1269740 DNA methylation BioSystems: REACTOME 7.592E-4 4.116E-3 2.147E-2
7.820E-2
 2 66
20 1269735 PRC2 methylates histones and DNA BioSystems: REACTOME 9.794E-4 5.044E-3 2.631E-2
1.009E-1
 2 75
21 1309112 Global Genome Nucleotide Excision Repair (GG-NER) BioSystems: REACTOME 1.256E-3 6.160E-3 3.214E-2
1.294E-1
 2 85
22 PW:0000416 sentrinization Pathway Ontology 1.927E-3 9.020E-3 4.706E-2
1.984E-1
 1 3
23 1269739 NoRC negatively regulates rRNA expression BioSystems: REACTOME 2.018E-3 9.036E-3 4.714E-2
2.078E-1
 2 108
24 1309111 Nucleotide Excision Repair BioSystems: REACTOME 2.168E-3 9.304E-3 4.853E-2
2.233E-1
 2 112
25 1339139 Activation of HOX genes during differentiation BioSystems: REACTOME 2.777E-3 1.100E-2
5.739E-2
2.860E-1
 2 127
26 1339140 Activation of anterior HOX genes in hindbrain development during early embryogenesis BioSystems: REACTOME 2.777E-3 1.100E-2
5.739E-2
2.860E-1
 2 127
27 PW:0000294 altered ubiquitin/proteasome degradation Pathway Ontology 3.209E-3 1.181E-2
6.159E-2
3.306E-1
 1 5
28 PW:0000144 ubiquitin/proteasome degradation Pathway Ontology 3.209E-3 1.181E-2
6.159E-2
3.306E-1
 1 5
29 83077 Jak-STAT signaling pathway BioSystems: KEGG 4.157E-3 1.476E-2
7.702E-2
4.282E-1
 2 156
30 1268742 SUMO is transferred from E1 to E2 (UBE2I, UBC9) BioSystems: REACTOME 4.490E-3 1.542E-2
8.043E-2
4.625E-1
 1 7
31 MAP00271 Methionine metabolism MAP00271 Methionine metabolism GenMAPP 5.130E-3 1.705E-2
8.893E-2
5.284E-1
 1 8
32 M5248 Jak-STAT Pathway MSigDB C2 BIOCARTA (v6.0) 5.770E-3 1.737E-2
9.063E-2
5.943E-1
 1 9
33 1269892 Formation of annular gap junctions BioSystems: REACTOME 5.770E-3 1.737E-2
9.063E-2
5.943E-1
 1 9
34 M7772 fl-arrestins in GPCR Desensitization MSigDB C2 BIOCARTA (v6.0) 6.409E-3 1.737E-2
9.063E-2
6.602E-1
 1 10
35 1268739 Processing and activation of SUMO BioSystems: REACTOME 6.409E-3 1.737E-2
9.063E-2
6.602E-1
 1 10
36 1269891 Gap junction degradation BioSystems: REACTOME 6.409E-3 1.737E-2
9.063E-2
6.602E-1
 1 10
37 M477 Gamma-aminobutyric Acid Receptor Life Cycle MSigDB C2 BIOCARTA (v6.0) 6.409E-3 1.737E-2
9.063E-2
6.602E-1
 1 10
38 1427845 Negative regulation of activity of TFAP2 (AP-2) family transcription factors BioSystems: REACTOME 6.409E-3 1.737E-2
9.063E-2
6.602E-1
 1 10
39 M668 Role of fl-arrestins in the activation and targeting of MAP kinases MSigDB C2 BIOCARTA (v6.0) 7.687E-3 2.030E-2
1.059E-1
7.918E-1
 1 12
40 1269315 Regulation of IFNG signaling BioSystems: REACTOME 8.963E-3 2.252E-2
1.175E-1
9.232E-1
 1 14
41 1269476 Retrograde neurotrophin signalling BioSystems: REACTOME 8.963E-3 2.252E-2
1.175E-1
9.232E-1
 1 14
42 M111 Roles of fl-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling MSigDB C2 BIOCARTA (v6.0) 9.601E-3 2.300E-2
1.200E-1
9.889E-1
 1 15
43 SMP00033 Methionine Metabolism SMPDB 9.601E-3 2.300E-2
1.200E-1
9.889E-1
 1 15
44 138015 Regulation of cytoplasmic and nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 1.215E-2 2.780E-2
1.450E-1
1.000E0
 1 19
45 M5940 Endocytotic role of NDK, Phosphins and Dynamin MSigDB C2 BIOCARTA (v6.0) 1.215E-2 2.780E-2
1.450E-1
1.000E0
 1 19
46 PW:0000015 Alzheimer disease Pathway Ontology 1.532E-2 3.431E-2
1.790E-1
1.000E0
 1 24
47 1270350 DNA Repair BioSystems: REACTOME 1.655E-2 3.626E-2
1.892E-1
1.000E0
 2 319
48 138052 Ephrin B reverse signaling BioSystems: Pathway Interaction Database 1.722E-2 3.678E-2
1.919E-1
1.000E0
 1 27
49 137936 IL12 signaling mediated by STAT4 BioSystems: Pathway Interaction Database 1.786E-2 3.678E-2
1.919E-1
1.000E0
 1 28
50 1269885 Gap junction trafficking BioSystems: REACTOME 1.786E-2 3.678E-2
1.919E-1
1.000E0
 1 28
Show 45 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 2662 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14752048 Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Pubmed 5.526E-14 1.471E-10 1.245E-9 1.471E-10 4 8
2 22072770 Contributions of CTCF and DNA methyltransferases DNMT1 and DNMT3B to Epstein-Barr virus restricted latency. Pubmed 6.031E-12 8.028E-9 6.795E-8 1.606E-8 3 3
3 15123615 Dynamin interacts with members of the sumoylation machinery. Pubmed 2.412E-11 1.605E-8 1.359E-7 6.422E-8 3 4
4 16148010 FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family. Pubmed 2.412E-11 1.605E-8 1.359E-7 6.422E-8 3 4
5 16154161 SUMO-1 modification of centrosomal protein hNinein promotes hNinein nuclear localization. Pubmed 6.030E-11 1.784E-8 1.510E-7 1.605E-7 3 5
6 15229330 Control of peroxisome proliferator-activated receptor gamma2 stability and activity by SUMOylation. Pubmed 6.030E-11 1.784E-8 1.510E-7 1.605E-7 3 5
7 12177000 PIAS1 and PIASxalpha function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. Pubmed 6.030E-11 1.784E-8 1.510E-7 1.605E-7 3 5
8 18413740 DNA methyltransferase 1 and 3B activate BAG-1 expression via recruitment of CTCFL/BORIS and modulation of promoter histone methylation. Pubmed 6.030E-11 1.784E-8 1.510E-7 1.605E-7 3 5
9 23202365 Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Pubmed 6.030E-11 1.784E-8 1.510E-7 1.605E-7 3 5
10 11867732 Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity. Pubmed 1.206E-10 2.469E-8 2.090E-7 3.210E-7 3 6
11 12867029 Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Pubmed 1.206E-10 2.469E-8 2.090E-7 3.210E-7 3 6
12 18157120 Developmentally regulated transcription of mammalian telomeres by DNA-dependent RNA polymerase II. Pubmed 1.206E-10 2.469E-8 2.090E-7 3.210E-7 3 6
13 16029420 Sumoylation modulates transcriptional activity of MITF in a promoter-specific manner. Pubmed 1.206E-10 2.469E-8 2.090E-7 3.210E-7 3 6
14 14609633 Association of the nucleocapsid protein of the Seoul and Hantaan hantaviruses with small ubiquitin-like modifier-1-related molecules. Pubmed 2.110E-10 3.304E-8 2.797E-7 5.617E-7 3 7
15 22162396 RNA-binding protein L1TD1 interacts with LIN28 via RNA and is required for human embryonic stem cell self-renewal and cancer cell proliferation. Pubmed 2.110E-10 3.304E-8 2.797E-7 5.617E-7 3 7
16 17283066 An acetylation/deacetylation-SUMOylation switch through a phylogenetically conserved psiKXEP motif in the tumor suppressor HIC1 regulates transcriptional repression activity. Pubmed 2.110E-10 3.304E-8 2.797E-7 5.617E-7 3 7
17 18656483 ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator. Pubmed 2.110E-10 3.304E-8 2.797E-7 5.617E-7 3 7
18 15120635 DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Pubmed 5.063E-10 6.739E-8 5.704E-7 1.348E-6 3 9
19 17533377 A crosstalk between hSiah2 and Pias E3-ligases modulates Pias-dependent activation. Pubmed 5.063E-10 6.739E-8 5.704E-7 1.348E-6 3 9
20 20972456 SUMO E3 ligase activity of TRIM proteins. Pubmed 5.063E-10 6.739E-8 5.704E-7 1.348E-6 3 9
21 22578841 An acetylation switch regulates SUMO-dependent protein interaction networks. Pubmed 7.233E-10 9.168E-8 7.760E-7 1.925E-6 3 10
22 24292684 CRL4B promotes tumorigenesis by coordinating with SUV39H1/HP1/DNMT3A in DNA methylation-based epigenetic silencing. Pubmed 3.373E-9 4.082E-7 3.455E-6 8.980E-6 3 16
23 24025402 An ENU mutagenesis screen identifies novel and known genes involved in epigenetic processes in the mouse. Pubmed 4.914E-9 5.688E-7 4.814E-6 1.308E-5 3 18
24 16524884 Specification of SUMO1- and SUMO2-interacting motifs. Pubmed 9.271E-9 9.872E-7 8.356E-6 2.468E-5 3 22
25 21233130 Rex1/Zfp42 as an epigenetic regulator for genomic imprinting. Pubmed 9.271E-9 9.872E-7 8.356E-6 2.468E-5 3 22
26 18499700 Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
27 24098518 Influence of DNMT genotype on global and site specific DNA methylation patterns in neonates and pregnant women. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
28 17067458 [Expression of DNA methyltransferases in salivary adenoid cystic carcinoma and its association with the CpG islands methylation of tumor suppressor genes]. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
29 25038421 DNA methyltransferase haplotype is associated with Alzheimer's disease. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
30 27169697 Age-dependent expression of DNMT1 and DNMT3B in PBMCs from a large European population enrolled in the MARK-AGE study. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
31 28300471 Decoupling of DNA methylation and activity of intergenic LINE-1 promoters in colorectal cancer. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
32 11932749 DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
33 14559786 Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
34 19798569 Two-stage case-control study of DNMT-1 and DNMT-3B gene variants and breast cancer risk. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
35 19965618 The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
36 18563322 Suppressing effects of down-regulating DNMT1 and DNMT3b expression on the growth of human cholangiocarcinoma cell line. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
37 25746661 Deregulation of DNMT1, DNMT3B and miR-29s in Burkitt lymphoma suggests novel contribution for disease pathogenesis. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
38 21592522 State-dependent changes in the expression of DNA methyltransferases in mood disorder patients. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
39 17657744 Association of the SUV39H1 histone methyltransferase with the DNA methyltransferase 1 at mRNA expression level in primary colorectal cancer. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
40 19399408 Effects on biological behavior of bladder carcinoma T24 cells via silencing DNMT1 and/or DNMT3b with shRNA in vitro. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
41 22559742 Ectopic ERK expression induces phenotypic conversion of C10 cells and alters DNA methyltransferase expression. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
42 23302691 H1 linker histone promotes epigenetic silencing by regulating both DNA methylation and histone H3 methylation. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
43 22236544 DNMT3B (C46359T) polymorphisms and immunoexpression of DNMT3b and DNMT1 proteins in oral lichen planus. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
44 21229291 Epigenetic regulation of DNA methyltransferases: DNMT1 and DNMT3B in gliomas. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
45 19450230 SUMOylation enhances DNA methyltransferase 1 activity. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
46 23079992 Association of DNMT1 and DNMT3B polymorphisms with breast cancer risk in Han Chinese women from South China. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
47 26339596 Effect of 50 Hz Extremely Low-Frequency Electromagnetic Fields on the DNA Methylation and DNA Methyltransferases in Mouse Spermatocyte-Derived Cell Line GC-2. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
48 23636699 No evidence for cumulative effects in a Dnmt3b hypomorph across multiple generations. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
49 19465937 DNA methyltransferase-mediated transcriptional silencing in malignant glioma: a combined whole-genome microarray and promoter array analysis. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
50 25420499 Mechanistic and biological significance of DNA methyltransferase 1 upregulated by growth factors in human hepatocellular carcinoma. Pubmed 3.839E-8 2.004E-6 1.696E-5 1.022E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 930 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:DNMT3A DNMT3A interactions 2.938E-14 2.733E-11 2.026E-10 2.733E-11 6 59
2 int:HIC1 HIC1 interactions 7.758E-13 3.607E-10 2.674E-9 7.215E-10 5 32
3 int:DNMT3B DNMT3B interactions 1.254E-10 3.888E-8 2.882E-7 1.166E-7 5 85
4 int:ZNF451 ZNF451 interactions 6.122E-10 1.423E-7 1.055E-6 5.693E-7 4 32
5 int:PIAS1 PIAS1 interactions 2.396E-9 4.457E-7 3.304E-6 2.228E-6 5 152
6 int:SUMO1 SUMO1 interactions 5.937E-9 9.203E-7 6.822E-6 5.522E-6 5 182
7 int:FLI1 FLI1 interactions 1.387E-7 1.842E-5 1.366E-4 1.290E-4 3 25
8 int:SETDB1 SETDB1 interactions 3.467E-7 3.721E-5 2.758E-4 3.225E-4 4 151
9 int:SUMO1P1 SUMO1P1 interactions 3.601E-7 3.721E-5 2.758E-4 3.349E-4 3 34
10 int:MBD1 MBD1 interactions 6.405E-7 5.957E-5 4.416E-4 5.957E-4 3 41
11 int:UBE2I UBE2I interactions 7.209E-7 6.095E-5 4.518E-4 6.704E-4 5 476
12 int:MITF MITF interactions 8.519E-7 6.602E-5 4.894E-4 7.923E-4 3 45
13 int:NR1H3 NR1H3 interactions 1.105E-6 7.341E-5 5.442E-4 1.028E-3 3 49
14 int:SP3 SP3 interactions 1.105E-6 7.341E-5 5.442E-4 1.028E-3 3 49
15 int:GLUL GLUL interactions 1.249E-6 7.742E-5 5.739E-4 1.161E-3 3 51
16 int:GRM8 GRM8 interactions 1.786E-6 9.769E-5 7.242E-4 1.661E-3 2 5
17 int:ZFP57 ZFP57 interactions 1.786E-6 9.769E-5 7.242E-4 1.661E-3 2 5
18 int:NR1H2 NR1H2 interactions 1.946E-6 1.005E-4 7.453E-4 1.810E-3 3 59
19 int:SMAD4 SMAD4 interactions 3.133E-6 1.473E-4 1.092E-3 2.913E-3 4 262
20 int:PML PML interactions 3.229E-6 1.473E-4 1.092E-3 3.003E-3 4 264
21 int:SIRT1 SIRT1 interactions 3.327E-6 1.473E-4 1.092E-3 3.094E-3 4 266
22 int:PLAG1 PLAG1 interactions 3.748E-6 1.585E-4 1.175E-3 3.486E-3 2 7
23 int:SREBF2 SREBF2 interactions 4.362E-6 1.764E-4 1.307E-3 4.057E-3 3 77
24 int:SUMO3 SUMO3 interactions 4.713E-6 1.826E-4 1.354E-3 4.383E-3 3 79
25 int:SIAH2 SIAH2 interactions 5.673E-6 2.110E-4 1.564E-3 5.276E-3 3 84
26 int:PLAGL2 PLAGL2 interactions 6.423E-6 2.297E-4 1.703E-3 5.973E-3 2 9
27 int:UHRF1 UHRF1 interactions 6.754E-6 2.327E-4 1.725E-3 6.282E-3 3 89
28 int:PIAS2 PIAS2 interactions 7.222E-6 2.399E-4 1.778E-3 6.717E-3 3 91
29 int:TRIM55 TRIM55 interactions 7.712E-6 2.473E-4 1.833E-3 7.172E-3 3 93
30 int:TRIM27 TRIM27 interactions 8.206E-6 2.544E-4 1.886E-3 7.632E-3 4 334
31 int:DNM1 DNM1 interactions 8.485E-6 2.546E-4 1.887E-3 7.891E-3 3 96
32 int:CLDN2 CLDN2 interactions 9.808E-6 2.798E-4 2.074E-3 9.122E-3 2 11
33 int:SNIP1 SNIP1 interactions 1.018E-5 2.798E-4 2.074E-3 9.471E-3 3 102
34 int:SUZ12 SUZ12 interactions 1.044E-5 2.798E-4 2.074E-3 9.713E-3 4 355
35 int:TRIM63 TRIM63 interactions 1.111E-5 2.798E-4 2.074E-3 1.033E-2 3 105
36 int:UHRF2 UHRF2 interactions 1.111E-5 2.798E-4 2.074E-3 1.033E-2 3 105
37 int:CHMP4B CHMP4B interactions 1.143E-5 2.798E-4 2.074E-3 1.063E-2 3 106
38 int:PIAS4 PIAS4 interactions 1.143E-5 2.798E-4 2.074E-3 1.063E-2 3 106
39 int:DNMT1 DNMT1 interactions 1.385E-5 3.304E-4 2.449E-3 1.288E-2 3 113
40 int:CBX1 CBX1 interactions 1.618E-5 3.679E-4 2.727E-3 1.505E-2 3 119
41 int:PLAGL1 PLAGL1 interactions 1.622E-5 3.679E-4 2.727E-3 1.508E-2 2 14
42 int:KLF3 KLF3 interactions 1.871E-5 4.056E-4 3.007E-3 1.740E-2 2 15
43 int:MTA1 MTA1 interactions 1.875E-5 4.056E-4 3.007E-3 1.744E-2 3 125
44 int:BAZ2A BAZ2A interactions 3.044E-5 6.434E-4 4.769E-3 2.831E-2 2 19
45 int:PPARG PPARG interactions 3.639E-5 7.521E-4 5.575E-3 3.384E-2 3 156
46 int:MBD4 MBD4 interactions 3.737E-5 7.554E-4 5.600E-3 3.475E-2 2 21
47 int:EHMT2 EHMT2 interactions 3.925E-5 7.766E-4 5.757E-3 3.650E-2 3 160
48 int:DAXX DAXX interactions 4.786E-5 9.216E-4 6.831E-3 4.451E-2 3 171
49 int:EGR2 EGR2 interactions 4.908E-5 9.216E-4 6.831E-3 4.564E-2 2 24
50 int:CREB1 CREB1 interactions 4.955E-5 9.216E-4 6.831E-3 4.608E-2 3 173
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16q21-q22.3 16q21-q22.3 2.020E-4 1.414E-3 3.666E-3 1.414E-3 1 1
2 20q11.2 20q11.2 5.441E-3 1.879E-2 4.871E-2 3.808E-2 1 27
3 18q21.1 18q21.1 8.051E-3 1.879E-2 4.871E-2
5.636E-2
 1 40
4 9q34 9q34 1.086E-2 1.900E-2 4.926E-2
7.599E-2
 1 54
5 Xp11.23 Xp11.23 2.022E-2 2.831E-2
7.341E-2
1.416E-1
 1 101

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 127 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F Q3 V$E2F Q3 3.062E-4 8.110E-3 4.400E-2 3.889E-2 3 177
2 V$E2F1 Q6 V$E2F1 Q6 3.270E-4 8.110E-3 4.400E-2 4.153E-2 3 181
3 V$E2F Q6 01 V$E2F Q6 01 3.433E-4 8.110E-3 4.400E-2 4.360E-2 3 184
4 V$E2F Q3 01 V$E2F Q3 01 3.544E-4 8.110E-3 4.400E-2 4.501E-2 3 186
5 V$E2F1 Q6 01 V$E2F1 Q6 01 3.715E-4 8.110E-3 4.400E-2 4.718E-2 3 189
6 V$E2F 03 V$E2F 03 3.831E-4 8.110E-3 4.400E-2 4.866E-2 3 191
7 V$LXR DR4 Q3 V$LXR DR4 Q3 1.539E-3 2.792E-2
1.515E-1
1.954E-1
 2 74
Show 2 more annotations

12: Gene Family [Display Chart] 8 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 85 Zinc fingers MIZ-type|SMC5-6 protein complex genenames.org 3.549E-6 2.129E-5 5.217E-5 2.129E-5 2 7
2 136 Zinc fingers CXXC-type genenames.org 5.265E-3 1.580E-2 3.870E-2 3.159E-2 1 12
3 1147 PHD finger proteins|Lysine methyltransferases|PWWP domain containing genenames.org 9.635E-3 1.927E-2 4.721E-2
5.781E-2
 1 22
4 487 Lysine methyltransferases|RNA binding motif containing genenames.org 1.486E-2 2.147E-2
5.260E-2
8.913E-2
 1 34
5 102 Ubiquitin conjugating enzymes E2 genenames.org 1.789E-2 2.147E-2
5.260E-2
1.073E-1
 1 41

13: Coexpression [Display Chart] 8 input genes in category / 849 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16458 Selected gradually up-regulated genes in the TLX1 [GeneID=3195] Tet On iEBHX15-4 cells (pro-erythroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.961E-6 1.665E-3 1.219E-2 1.665E-3 3 77
2 M4925 Up-regulated genes classifying non-tumor lung tissues by age after incution of lung cancer by urethane injection [PubChem=5641]: early (24-26 weeks) vs late (46 weeks). MSigDB C2: CGP Curated Gene Sets (v6.0) 8.452E-6 3.588E-3 2.627E-2 7.176E-3 3 125
3 M1770 Genes required for epigenetic silencing of FAS [GeneID=355] by activated KRAS [GeneID=3845] in NIH 3T3 cells, based on RNAi screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.386E-5 5.860E-3 4.291E-2 2.875E-2 2 26
4 M8861 Genes down-regulated in lymphoid primed multipotent progenitors versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 5.860E-3 4.291E-2 2.930E-2 3 200
5 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 3.451E-5 5.860E-3 4.291E-2 2.930E-2 3 200
6 M7933 Cluster 1: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.642E-4 3.368E-2
2.466E-1
2.243E-1
 2 72
7 M1421 Cell proliferation genes down-regulated by histone deacetylase (HDAC) inhibitors SAHA and depsipeptide [PubChem=5311;5352062]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.944E-4 3.368E-2
2.466E-1
2.499E-1
 2 76
8 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.174E-4 3.368E-2
2.466E-1
2.694E-1
 3 423
9 18535662-TableS1b Mouse Lymphoma Wu08 1114genes GeneSigDB 5.031E-4 3.634E-2
2.661E-1
4.271E-1
 3 495
10 M5908 Genes defining response to androgens. MSigDB H: Hallmark Gene Sets (v6.0) 5.193E-4 3.634E-2
2.661E-1
4.409E-1
 2 101
11 M2895 Genes up-regulated in MEF cells (embryonic fibroblasts) isolated from RB1 [GeneID=5925] knockout mice: chronic loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.725E-4 3.634E-2
2.661E-1
5.709E-1
 2 115
12 M360 Genes up-regulated in macrophages differentiated in the presence of IL4 [GeneID=3565] and dexamethasone [PubChem=5743] for 5 days versus those subsequently treated with TGFB1 [GeneID=7040] for 3h. MSigDB C7: Immunologic Signatures (v6.0) 1.095E-3 3.634E-2
2.661E-1
9.295E-1
 2 147
13 M18811 Genes constituting the XPRSS-Int network: intersection of genes whose expression correlates with BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200] in a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.426E-3 3.634E-2
2.661E-1
1.000E0
 2 168
14 M3487 Genes up-regulated in naive CD4 [GeneID=920] T cells from adult blood versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.634E-2
2.661E-1
1.000E0
 2 198
15 M4302 Genes down-regulated in comparison of effector CD8 IL2RA [GeneID=3559] low T cells versus effector CD8 IL2RA [GeneID=3559] high cells. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.634E-2
2.661E-1
1.000E0
 2 198
16 M7673 Genes up-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes (96h): Pam2CSK4 versus tretinoin [PubChem=444795] and Pam2CSK4. MSigDB C7: Immunologic Signatures (v6.0) 1.972E-3 3.634E-2
2.661E-1
1.000E0
 2 198
17 M5411 Genes down-regulated in comparison of eosinophils versus B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.634E-2
2.661E-1
1.000E0
 2 199
18 M4775 Genes up-regulated in comparison of lineage negative versus CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.634E-2
2.661E-1
1.000E0
 2 199
19 M7651 Genes down-regulated in CD4 [GeneID=920] T cells under specific pathogen free conditions: healthy versus arthritis (KRN model). MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.634E-2
2.661E-1
1.000E0
 2 199
20 M9632 Genes down-regulated in CD4 [GeneID=920] T helper cells (42h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
21 M3070 Genes down-regulated in comparison of effector CD8 T cells KRLG1 Int [GeneID=10219] vs those with KRLG1 Hi. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
22 M4003 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
23 M7549 Genes down-regulated in double positive thymocytes: untreated versus stimulated by anti-CD3. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
24 M9660 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 20h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
25 M9076 Genes up-regulated in memory CD8 T cells: ITGAE- [GeneID=3682] from spleen versus ITGAE+ [GeneID=3682] from brain. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
26 M5604 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells versus those treated with TGFB1 [GeneID=7040] and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
27 M3877 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
28 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
29 M7829 Genes down-regulated in amplified multipotent progenitors versus cultured untreated common dendritic cell progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
30 M8959 Genes up-regulated in lymph node from aged PPARG [GeneID=5468] knockout mice: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
31 M7795 Genes up-regulated in neutrophils: LPS versus stimulated by CSF2 and IFNG [GeneID=1437;3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
32 M6961 Genes down-regulated in plasmacytoid dendritic cells in response to CpG oligodeoxynucleotide 1826: 1h versus 4h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
33 M8266 Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 16h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
34 M4056 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
35 M5157 Genes up-regulated in comparison of macrophages versus macrophages exposed to L.donovani. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
36 M6550 Genes down-regulated in CD8 T cells: control versus over-expressing TERT [GeneID=7015]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
37 M6959 Genes down-regulated in plasmacytoid dendritic cells (4h): CpG oligodeoxynucleotide 1826 versus influenza virus infection. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
38 M7530 Genes up-regulated in stimulated by anti-CD3 double positive thymocytes: ELK1 [GeneID=2002] knockout versus ELK1 and ELK4 [GeneID=2002;2005] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
39 M5997 Genes up-regulated in macrophages treated by IL6 [GeneID=3569]: 100min versus 400min. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
40 M4239 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 1 h versus the untreated cells at 72 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
41 M6039 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 [GeneID=7040] and IL-12 (48h) versus untreated (48h). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
42 M6940 Genes up-regulated in B lymphocytes: CpG oligodeoxynucleotide 1826 versus anti IgM and CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
43 M4787 Genes up-regulated in comparison of lineage negative versus NKT cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
44 M3770 Genes down-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with CpG DNA (TLR9 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
45 M4578 Genes down-regulated in comparison of adult thymic progenitors versus fetal thymic progenitors. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
46 M9845 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4high versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4intermediate. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
47 M9453 Genes down-regulated in CD8 T cells during chronic infection with LCMV-Clone 13: effectors at day 15 versus exhausted at day 30. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.634E-2
2.661E-1
1.000E0
 2 200
48 M224 Methylated germline-specific genes with high-CpG-density promoters (HCP) in primary fibroblasts. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.073E-3 3.667E-2
2.685E-1
1.000E0
 1 6
49 17640171-Table3 Human Breast Lee07 7genes GeneSigDB 2.418E-3 4.106E-2
3.006E-1
1.000E0
 1 7
50 M4163 Up-regulated genes associated with sensitivity and resistance to gamma-secretase (GSI) in T-cell acute lymphoblastic leukemia (T-ALL) cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.418E-3 4.106E-2
3.006E-1
1.000E0
 1 7
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 546 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Lungmap Mouse Lung E16.5 Proliferative fibroblast Subtype Early fibroblastic progenitor Lungmap Mouse Lung E16.5 Proliferative fibroblast Subtype Early fibroblastic progenitor Lungmap CCHMC 9.496E-6 5.185E-3 3.568E-2 5.185E-3 4 427

15: Computational [Display Chart] 8 input genes in category / 97 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 8 input genes in category / 371 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-718:mirSVR highEffct hsa-miR-718:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.707E-5 6.334E-3 4.114E-2 6.334E-3 2 57
2 hsa-miR-3140-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.128E-5 1.082E-2
7.025E-2
 3.016E-2 2 124
3 hsa-miR-375:mirSVR highEffct hsa-miR-375:mirSVR conserved highEffect-0.5 MicroRNA.org 1.527E-4 1.082E-2
7.025E-2
5.666E-2
 2 170
4 hsa-miR-496:PITA hsa-miR-496:PITA TOP PITA 1.527E-4 1.082E-2
7.025E-2
5.666E-2
 2 170
5 hsa-miR-200b-3p:Functional MTI Functional MTI miRTarbase 1.827E-4 1.082E-2
7.025E-2
6.780E-2
 2 186
6 hsa-miR-148a-3p:Functional MTI Functional MTI miRTarbase 2.395E-4 1.082E-2
7.025E-2
8.884E-2
 2 213
7 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 2.417E-4 1.082E-2
7.025E-2
8.967E-2
 2 214
8 hsa-miR-6783-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.624E-4 1.082E-2
7.025E-2
9.734E-2
 2 223
9 hsa-miR-1343-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.624E-4 1.082E-2
7.025E-2
9.734E-2
 2 223
10 hsa-miR-29b-3p:Functional MTI Functional MTI miRTarbase 3.589E-4 1.088E-2
7.064E-2
1.332E-1
 2 261
11 hsa-miR-1301:PITA hsa-miR-1301:PITA TOP PITA 3.616E-4 1.088E-2
7.064E-2
1.342E-1
 2 262
12 hsa-miR-29a-3p:Functional MTI Functional MTI miRTarbase 3.699E-4 1.088E-2
7.064E-2
1.372E-1
 2 265
13 hsa-miR-618:PITA hsa-miR-618:PITA TOP PITA 3.811E-4 1.088E-2
7.064E-2
1.414E-1
 2 269
14 hsa-miR-3181:mirSVR lowEffct hsa-miR-3181:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 5.117E-4 1.356E-2
8.808E-2
1.899E-1
 2 312
15 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 6.538E-4 1.617E-2
1.050E-1
2.426E-1
 2 353
16 hsa-miR-4281:mirSVR lowEffct hsa-miR-4281:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.796E-4 2.040E-2
1.325E-1
3.263E-1
 2 410
17 hsa-miR-132*:mirSVR lowEffct hsa-miR-132*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.532E-4 2.080E-2
1.351E-1
3.537E-1
 2 427
18 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 1.090E-3 2.147E-2
1.395E-1
4.045E-1
 2 457
19 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 1.100E-3 2.147E-2
1.395E-1
4.080E-1
 2 459
20 hsa-miR-369-5p:Functional MTI Functional MTI miRTarbase 1.218E-3 2.259E-2
1.467E-1
4.517E-1
 1 11
21 hsa-miR-8088:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.328E-3 2.346E-2
1.524E-1
4.928E-1
 1 12
22 hsa-miR-29c-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.439E-3 2.426E-2
1.576E-1
5.338E-1
 1 13
23 hsa-miR-4798-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.549E-3 2.499E-2
1.623E-1
5.748E-1
 1 14
24 hsa-miR-196b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.771E-3 2.737E-2
1.778E-1
6.569E-1
 1 16
25 hsa-miR-652:PITA hsa-miR-652:PITA TOP PITA 1.992E-3 2.956E-2
1.920E-1
7.389E-1
 1 18
26 hsa-miR-3171:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 4.452E-2
2.891E-1
1.000E0
 1 42
27 GTAAACC,MIR-299-5P:MSigDB GTAAACC,MIR-299-5P:MSigDB MSigDB 5.414E-3 4.452E-2
2.891E-1
1.000E0
 1 49
28 hsa-miR-598:PITA hsa-miR-598:PITA TOP PITA 5.414E-3 4.452E-2
2.891E-1
1.000E0
 1 49
29 hsa-miR-548q:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.414E-3 4.452E-2
2.891E-1
1.000E0
 1 49
30 hsa-miR-1278:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.634E-3 4.452E-2
2.891E-1
1.000E0
 1 51
31 hsa-miR-1322:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.854E-3 4.452E-2
2.891E-1
1.000E0
 1 53
32 hsa-miR-6740-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.075E-3 4.452E-2
2.891E-1
1.000E0
 1 55
33 hsa-miR-126-3p:Functional MTI Functional MTI miRTarbase 6.295E-3 4.452E-2
2.891E-1
1.000E0
 1 57
34 CAAGGAT,MIR-362:MSigDB CAAGGAT,MIR-362:MSigDB MSigDB 6.405E-3 4.452E-2
2.891E-1
1.000E0
 1 58
35 GTGGTGA,MIR-197:MSigDB GTGGTGA,MIR-197:MSigDB MSigDB 7.286E-3 4.452E-2
2.891E-1
1.000E0
 1 66
36 hsa-miR-4666b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.506E-3 4.452E-2
2.891E-1
1.000E0
 1 68
37 hsa-miR-6789-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.616E-3 4.452E-2
2.891E-1
1.000E0
 1 69
38 hsa-miR-566:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.616E-3 4.452E-2
2.891E-1
1.000E0
 1 69
39 hsa-miR-6126:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.726E-3 4.452E-2
2.891E-1
1.000E0
 1 70
40 AAGGGAT,MIR-188:MSigDB AAGGGAT,MIR-188:MSigDB MSigDB 7.836E-3 4.452E-2
2.891E-1
1.000E0
 1 71
41 hsa-miR-4720-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.276E-3 4.452E-2
2.891E-1
1.000E0
 1 75
42 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.496E-3 4.452E-2
2.891E-1
1.000E0
 1 77
43 hsa-miR-7108-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.606E-3 4.452E-2
2.891E-1
1.000E0
 1 78
44 hsa-miR-217:Functional MTI Functional MTI miRTarbase 8.825E-3 4.452E-2
2.891E-1
1.000E0
 1 80
45 hsa-miR-4304:mirSVR highEffct hsa-miR-4304:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.935E-3 4.452E-2
2.891E-1
1.000E0
 1 81
46 hsa-miR-339-3p:mirSVR highEffct hsa-miR-339-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.155E-3 4.452E-2
2.891E-1
1.000E0
 1 83
47 hsa-miR-133b:Functional MTI Functional MTI miRTarbase 9.265E-3 4.452E-2
2.891E-1
1.000E0
 1 84
48 AGGCACT,MIR-515-3P:MSigDB AGGCACT,MIR-515-3P:MSigDB MSigDB 9.375E-3 4.452E-2
2.891E-1
1.000E0
 1 85
49 hsa-miR-1183:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.375E-3 4.452E-2
2.891E-1
1.000E0
 1 85
50 hsa-miR-1234:mirSVR highEffct hsa-miR-1234:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.704E-3 4.452E-2
2.891E-1
1.000E0
 1 88
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 1427 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C581203 SGI-1027 CTD 3.220E-7 4.595E-4 3.603E-3 4.595E-4 2 3
2 CID000446591 AC1O6W2C Stitch 1.882E-6 1.008E-3 7.903E-3 2.685E-3 3 75
3 CID000001404 AC1L1BEH Stitch 2.119E-6 1.008E-3 7.903E-3 3.024E-3 3 78
4 CID000099207 epsilon-rhodomycinone Stitch 3.860E-6 1.147E-3 8.995E-3 5.508E-3 2 9
5 CID000000340 3-methylcatechol Stitch 4.223E-6 1.147E-3 8.995E-3 6.026E-3 3 98
6 CID000075233 5-bromocytosine Stitch 4.824E-6 1.147E-3 8.995E-3 6.883E-3 2 10
7 CID000444208 C-E6 Stitch 7.072E-6 1.148E-3 9.001E-3 1.009E-2 2 12
8 CID000160128 AC1L4N3B Stitch 8.357E-6 1.148E-3 9.001E-3 1.193E-2 2 13
9 ctd:C067134 8-oxo-7-hydrodeoxyguanosine CTD 8.357E-6 1.148E-3 9.001E-3 1.193E-2 2 13
10 CID000000597 cytosine Stitch 9.024E-6 1.148E-3 9.001E-3 1.288E-2 4 441
11 CID000327966 AC1L71LN Stitch 9.431E-6 1.148E-3 9.001E-3 1.346E-2 3 128
12 CID000000624 ST013873 Stitch 9.654E-6 1.148E-3 9.001E-3 1.378E-2 3 129
13 CID000408161 N-methyl-5H-purin-6-amine Stitch 1.638E-5 1.798E-3 1.410E-2 2.337E-2 2 18
14 CID001356208 AC1LXO3B Stitch 2.706E-5 2.543E-3 1.994E-2 3.861E-2 2 23
15 7085 DN GW8510; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.706E-5 2.543E-3 1.994E-2 3.861E-2 3 182
16 ctd:D003676 Deferoxamine CTD 2.888E-5 2.543E-3 1.994E-2 4.120E-2 3 186
17 1225 DN 17-AAG; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.125E-5 2.543E-3 1.994E-2 4.460E-2 3 191
18 CID000016861 5-fluorocytidine Stitch 3.207E-5 2.543E-3 1.994E-2 4.577E-2 2 25
19 1407 UP Etodolac [41340-25-4]; Up 200; 14uM; HL60; HG-U133A Broad Institute CMAP Up 3.480E-5 2.613E-3 2.049E-2 4.966E-2 3 198
20 CID000012232 dimethyl disulfide Stitch 4.338E-5 2.947E-3 2.311E-2
6.190E-2
 2 29
21 CID000151108 quebrachitol Stitch 4.338E-5 2.947E-3 2.311E-2
6.190E-2
 2 29
22 CID000000193 S-adenosyl-D-homocysteine Stitch 4.893E-5 3.174E-3 2.489E-2
6.983E-2
 3 222
23 ctd:C479580 procyanidin B2 CTD 5.637E-5 3.360E-3 2.634E-2
8.044E-2
 2 33
24 CID000065040 5-methylcytosine Stitch 5.651E-5 3.360E-3 2.634E-2
8.064E-2
 3 233
25 ctd:D004391 Dust CTD 6.019E-5 3.436E-3 2.694E-2
8.589E-2
 3 238
26 CID000067955 N6-methyladenine Stitch 6.350E-5 3.485E-3 2.733E-2
9.062E-2
 2 35
27 CID000092918 5-methylcytidine Stitch 7.105E-5 3.755E-3 2.945E-2
1.014E-1
 2 37
28 CID000001835 5-methyl-2'-deoxycytidine Stitch 8.317E-5 4.093E-3 3.209E-2
1.187E-1
 2 40
29 CID000474523 22,26-azasterol Stitch 8.742E-5 4.093E-3 3.209E-2
1.248E-1
 2 41
30 ctd:C031763 1,3-butadiene CTD 8.742E-5 4.093E-3 3.209E-2
1.248E-1
 2 41
31 CID000444708 N-methylmesoporphyrin Stitch 9.178E-5 4.093E-3 3.209E-2
1.310E-1
 2 42
32 ctd:C009684 withaferin A CTD 9.178E-5 4.093E-3 3.209E-2
1.310E-1
 2 42
33 CID000003763 isoflurane Stitch 9.649E-5 4.172E-3 3.272E-2
1.377E-1
 3 279
34 CID002867154 AC1MF7BR Stitch 1.008E-4 4.231E-3 3.317E-2
1.438E-1
 2 44
35 CID000100016 zebularine Stitch 1.357E-4 5.532E-3 4.338E-2
1.936E-1
 2 51
36 ctd:C023617 pregna-4,17-diene-3,16-dione CTD 1.697E-4 6.726E-3
5.274E-2
2.421E-1
 2 57
37 CID000001079 S-adenosylmethionine Stitch 1.967E-4 7.574E-3
5.939E-2
2.808E-1
 3 355
38 CID000002336 benzo(a)pyrene Stitch 2.017E-4 7.574E-3
5.939E-2
2.878E-1
 3 358
39 ctd:D053119 Benzophenanthridines CTD 2.346E-4 8.586E-3
6.732E-2
3.348E-1
 2 67
40 ctd:C037219 quinoline CTD 2.417E-4 8.623E-3
6.761E-2
3.449E-1
 2 68
41 CID011497471 R A J Stitch 2.863E-4 9.965E-3
7.813E-2
4.086E-1
 2 74
42 DB01099 Flucytosine Drug Bank 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
43 ctd:C569675 5-(N,N-dimethylaminomethyl)-3-(4-nitrophenyl)-4,5-dihydroisoxazole CTD 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
44 ctd:C508801 NSC 303530 CTD 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
45 DB01262 Decitabine Drug Bank 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
46 ctd:C009765 lac dye CTD 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
47 DB00928 Azacitidine Drug Bank 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
48 ctd:C508802 NSC 401077 CTD 3.502E-4 1.041E-2
8.164E-2
4.998E-1
 1 1
49 CID000001099 sulfite Stitch 3.651E-4 1.063E-2
8.336E-2
5.209E-1
 3 438
50 CID003036909 CTDs Stitch 4.328E-4 1.235E-2
9.684E-2
6.176E-1
 2 91
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 349 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1336076 Sporadic Breast Carcinoma DisGeNET BeFree 5.294E-5 9.572E-3
6.158E-2
 1.847E-2 3 162
2 C0024131 Lupus Vulgaris DisGeNET BeFree 2.942E-4 9.572E-3
6.158E-2
1.027E-1
 3 289
3 C0409974 Lupus Erythematosus DisGeNET BeFree 3.156E-4 9.572E-3
6.158E-2
1.102E-1
 3 296
4 C0024138 Lupus Erythematosus, Discoid DisGeNET Curated 3.381E-4 9.572E-3
6.158E-2
1.180E-1
 3 303
5 C0030809 Pemphigus Vulgaris DisGeNET BeFree 3.973E-4 9.572E-3
6.158E-2
1.387E-1
 2 62
6 C0004936 Mental disorders DisGeNET Curated 4.005E-4 9.572E-3
6.158E-2
1.398E-1
 3 321
7 C0019187 Hepatitis, Alcoholic DisGeNET Curated 4.234E-4 9.572E-3
6.158E-2
1.478E-1
 2 64
8 C1856689 FRIEDREICH ATAXIA 1 DisGeNET Curated 4.367E-4 9.572E-3
6.158E-2
1.524E-1
 2 65
9 C0004903 Beckwith-Wiedemann Syndrome DisGeNET Curated 4.367E-4 9.572E-3
6.158E-2
1.524E-1
 2 65
10 cv:C1858804 Cerebellar ataxia, deafness, and narcolepsy Clinical Variations 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
11 cv:CN180640 Mental retardation, autosomal dominant 21 Clinical Variations 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
12 C1858804 Cerebellar Ataxia, Deafness, and Narcolepsy DisGeNET BeFree 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
13 cv:C3279885 NEUROPATHY, HEREDITARY SENSORY, TYPE IE Clinical Variations 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
14 cv:C0398788 Centromeric instability of chromosomes 1,9 and 16 and immunodeficiency Clinical Variations 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
15 C4225357 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 31 DisGeNET Curated 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
16 OMIN:242860 IMMUNODEFICIENCY-CENTROMERIC INSTABILITY-FACIAL ANOMALIES SYNDROME OMIM 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
17 C3809686 MENTAL RETARDATION, AUTOSOMAL DOMINANT 21 DisGeNET Curated 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
18 C3279885 Hereditary Sensory and Autonomic Neuropathy Type Ie DisGeNET Curated 4.937E-4 9.572E-3
6.158E-2
1.723E-1
 1 1
19 C3807295 CEREBELLAR ATAXIA, DEAFNESS, AND NARCOLEPSY, AUTOSOMAL DOMINANT DisGeNET Curated 9.871E-4 1.635E-2
1.052E-1
3.445E-1
 1 2
20 C0238288 Muscular Dystrophy, Facioscapulohumeral DisGeNET Curated 1.010E-3 1.635E-2
1.052E-1
3.525E-1
 2 99
21 C0032927 Precancerous Conditions DisGeNET Curated 1.012E-3 1.635E-2
1.052E-1
3.533E-1
 3 441
22 C0028960 Oligospermia DisGeNET Curated 1.030E-3 1.635E-2
1.052E-1
3.596E-1
 2 100
23 C0206687 Carcinoma, Endometrioid DisGeNET Curated 1.114E-3 1.690E-2
1.087E-1
3.887E-1
 2 104
24 C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 1.203E-3 1.749E-2
1.125E-1
4.197E-1
 3 468
25 C0432222 Spondyloenchondrodysplasia DisGeNET Curated 1.480E-3 1.987E-2
1.278E-1
5.167E-1
 1 3
26 C0410192 Muscular Dystrophy, Scapulohumeral DisGeNET Curated 1.480E-3 1.987E-2
1.278E-1
5.167E-1
 1 3
27 C0035372 Rett Syndrome DisGeNET Curated 1.654E-3 2.138E-2
1.376E-1
5.774E-1
 2 127
28 C0262404 Cerebellar degeneration DisGeNET Curated 1.894E-3 2.361E-2
1.519E-1
6.610E-1
 2 136
29 C0595948 Atypical absence seizure DisGeNET Curated 2.466E-3 2.777E-2
1.786E-1
8.607E-1
 1 5
30 C0398788 Immunodeficiency syndrome, variable DisGeNET Curated 2.466E-3 2.777E-2
1.786E-1
8.607E-1
 1 5
31 C4023479 EEG with focal sharp slow waves DisGeNET Curated 2.466E-3 2.777E-2
1.786E-1
8.607E-1
 1 5
32 C3241937 Nonalcoholic Steatohepatitis DisGeNET BeFree 2.871E-3 3.037E-2
1.954E-1
1.000E0
 2 168
33 C1861305 TARSAL-CARPAL COALITION SYNDROME DisGeNET Curated 2.905E-3 3.037E-2
1.954E-1
1.000E0
 2 169
34 C1834671 FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY 1B DisGeNET Curated 2.959E-3 3.037E-2
1.954E-1
1.000E0
 1 6
35 C0019189 Hepatitis, Chronic DisGeNET Curated 3.181E-3 3.172E-2
2.041E-1
1.000E0
 2 177
36 C1838319 Primitive reflexes (palmomental, snout, glabellar) DisGeNET Curated 3.451E-3 3.225E-2
2.075E-1
1.000E0
 1 7
37 C1850601 Brainstem abnormalities DisGeNET Curated 3.451E-3 3.225E-2
2.075E-1
1.000E0
 1 7
38 C1860789 Leukemia, Megakaryoblastic, of Down Syndrome DisGeNET Curated 3.943E-3 3.225E-2
2.075E-1
1.000E0
 1 8
39 C0748607 Recurrent seizures DisGeNET BeFree 3.943E-3 3.225E-2
2.075E-1
1.000E0
 1 8
40 C1836508 Hypertonic seizures DisGeNET Curated 3.943E-3 3.225E-2
2.075E-1
1.000E0
 1 8
41 C1176475 Ductal Carcinoma DisGeNET Curated 4.121E-3 3.225E-2
2.075E-1
1.000E0
 2 202
42 C0494463 Alzheimer Disease, Late Onset DisGeNET BeFree 4.363E-3 3.225E-2
2.075E-1
1.000E0
 2 208
43 C0206659 Embryonal Carcinoma DisGeNET BeFree 4.404E-3 3.225E-2
2.075E-1
1.000E0
 2 209
44 C0699739 Sensory Neuropathy, Hereditary DisGeNET BeFree 4.435E-3 3.225E-2
2.075E-1
1.000E0
 1 9
45 C0021125 Impulsive Behavior DisGeNET Curated 4.435E-3 3.225E-2
2.075E-1
1.000E0
 1 9
46 C1656427 early onset schizophrenia DisGeNET Curated 4.435E-3 3.225E-2
2.075E-1
1.000E0
 1 9
47 C0009451 Communicating Hydrocephalus DisGeNET Curated 4.435E-3 3.225E-2
2.075E-1
1.000E0
 1 9
48 C0238111 Lennox-Gastaut syndrome DisGeNET Curated 4.435E-3 3.225E-2
2.075E-1
1.000E0
 1 9
49 C1134719 Invasive Ductal Breast Carcinoma DisGeNET Curated 4.654E-3 3.315E-2
2.133E-1
1.000E0
 2 215
50 C0036631 Seminoma DisGeNET Curated 4.782E-3 3.338E-2
2.147E-1
1.000E0
 2 218
Show 45 more annotations