Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc103_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 28 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031683 G-protein beta/gamma-subunit complex binding 1.771E-20 4.960E-19 1.948E-18 4.960E-19 7 24
2 GO:0003924 GTPase activity 3.747E-13 4.525E-12 1.777E-11 1.049E-11 7 236
3 GO:0031821 G protein-coupled serotonin receptor binding 4.848E-13 4.525E-12 1.777E-11 1.357E-11 4 7
4 GO:0001664 G protein-coupled receptor binding 1.134E-12 7.937E-12 3.117E-11 3.175E-11 7 276
5 GO:0005525 GTP binding 1.041E-11 5.831E-11 2.290E-10 2.916E-10 7 378
6 GO:0032561 guanyl ribonucleotide binding 1.523E-11 6.202E-11 2.436E-10 4.265E-10 7 399
7 GO:0019001 guanyl nucleotide binding 1.550E-11 6.202E-11 2.436E-10 4.341E-10 7 400
8 GO:0032794 GTPase activating protein binding 4.207E-8 1.472E-7 5.783E-7 1.178E-6 3 18
9 GO:0031752 D5 dopamine receptor binding 4.824E-7 1.501E-6 5.893E-6 1.351E-5 2 3
10 GO:0050780 dopamine receptor binding 3.699E-5 1.036E-4 4.068E-4 1.036E-3 2 22
11 GO:0019003 GDP binding 2.718E-4 6.919E-4 2.717E-3 7.611E-3 2 59
12 GO:0031852 mu-type opioid receptor binding 1.714E-3 3.691E-3 1.450E-2 4.799E-2 1 4
13 GO:0051430 corticotropin-releasing hormone receptor 1 binding 1.714E-3 3.691E-3 1.450E-2 4.799E-2 1 4
14 GO:0051429 corticotropin-releasing hormone receptor binding 2.570E-3 5.140E-3 2.018E-2
7.195E-2
 1 6
15 GO:0031628 opioid receptor binding 3.853E-3 7.191E-3 2.824E-2
1.079E-1
 1 9
16 GO:0031702 type 1 angiotensin receptor binding 4.280E-3 7.490E-3 2.941E-2
1.198E-1
 1 10
17 GO:0031701 angiotensin receptor binding 5.134E-3 8.456E-3 3.321E-2
1.437E-1
 1 12
18 GO:0051428 peptide hormone receptor binding 7.266E-3 1.130E-2 4.439E-2
2.035E-1
 1 17
19 GO:0071855 neuropeptide receptor binding 1.322E-2 1.948E-2
7.648E-2
3.700E-1
 1 31
20 GO:0005089 Rho guanyl-nucleotide exchange factor activity 3.379E-2 4.731E-2
1.858E-1
9.462E-1
 1 80
Show 15 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 192 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 2.102E-14 4.035E-12 2.355E-11 4.035E-12 7 157
2 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 6.504E-14 6.244E-12 3.645E-11 1.249E-11 7 184
3 GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 1.588E-8 8.164E-7 4.766E-6 3.050E-6 4 74
4 GO:0006457 protein folding 1.701E-8 8.164E-7 4.766E-6 3.266E-6 5 236
5 GO:0007266 Rho protein signal transduction 3.505E-5 1.346E-3 7.855E-3 6.729E-3 3 162
6 GO:0007194 negative regulation of adenylate cyclase activity 4.820E-5 1.543E-3 9.004E-3 9.255E-3 2 25
7 GO:0031280 negative regulation of cyclase activity 5.637E-5 1.546E-3 9.026E-3 1.082E-2 2 27
8 GO:0051350 negative regulation of lyase activity 6.518E-5 1.564E-3 9.132E-3 1.251E-2 2 29
9 GO:0008016 regulation of heart contraction 1.157E-4 2.279E-3 1.330E-2 2.221E-2 3 242
10 GO:0007212 dopamine receptor signaling pathway 1.187E-4 2.279E-3 1.330E-2 2.279E-2 2 39
11 GO:1900372 negative regulation of purine nucleotide biosynthetic process 1.445E-4 2.313E-3 1.350E-2 2.775E-2 2 43
12 GO:0030809 negative regulation of nucleotide biosynthetic process 1.445E-4 2.313E-3 1.350E-2 2.775E-2 2 43
13 GO:0060047 heart contraction 1.707E-4 2.416E-3 1.411E-2 3.277E-2 3 276
14 GO:0003015 heart process 1.762E-4 2.416E-3 1.411E-2 3.383E-2 3 279
15 GO:0007265 Ras protein signal transduction 2.968E-4 3.594E-3 2.098E-2
5.699E-2
 3 333
16 GO:1903522 regulation of blood circulation 2.995E-4 3.594E-3 2.098E-2
5.750E-2
 3 334
17 GO:1900543 negative regulation of purine nucleotide metabolic process 3.627E-4 4.096E-3 2.391E-2
6.963E-2
 2 68
18 GO:0045980 negative regulation of nucleotide metabolic process 3.843E-4 4.099E-3 2.393E-2
7.379E-2
 2 70
19 GO:0045761 regulation of adenylate cyclase activity 4.295E-4 4.340E-3 2.533E-2
8.245E-2
 2 74
20 GO:0050805 negative regulation of synaptic transmission 4.529E-4 4.348E-3 2.538E-2
8.697E-2
 2 76
21 GO:0031279 regulation of cyclase activity 6.068E-4 5.538E-3 3.233E-2
1.165E-1
 2 88
22 GO:0051339 regulation of lyase activity 6.346E-4 5.538E-3 3.233E-2
1.218E-1
 2 90
23 GO:0006171 cAMP biosynthetic process 1.258E-3 1.050E-2
6.129E-2
2.415E-1
 2 127
24 GO:0008360 regulation of cell shape 1.702E-3 1.308E-2
7.634E-2
3.268E-1
 2 148
25 GO:1900371 regulation of purine nucleotide biosynthetic process 1.748E-3 1.308E-2
7.634E-2
3.356E-1
 2 150
26 GO:0030808 regulation of nucleotide biosynthetic process 1.771E-3 1.308E-2
7.634E-2
3.400E-1
 2 151
27 GO:0052652 cyclic purine nucleotide metabolic process 1.889E-3 1.312E-2
7.656E-2
3.626E-1
 2 156
28 GO:0009190 cyclic nucleotide biosynthetic process 1.913E-3 1.312E-2
7.656E-2
3.672E-1
 2 157
29 GO:0046058 cAMP metabolic process 2.010E-3 1.331E-2
7.768E-2
3.859E-1
 2 161
30 GO:0030168 platelet activation 2.186E-3 1.399E-2
8.166E-2
4.197E-1
 2 168
31 GO:0031584 activation of phospholipase D activity 3.004E-3 1.860E-2
1.086E-1
5.767E-1
 1 7
32 GO:0009187 cyclic nucleotide metabolic process 3.263E-3 1.958E-2
1.143E-1
6.265E-1
 2 206
33 GO:1900542 regulation of purine nucleotide metabolic process 3.946E-3 2.287E-2
1.335E-1
7.577E-1
 2 227
34 GO:0006140 regulation of nucleotide metabolic process 4.223E-3 2.287E-2
1.335E-1
8.108E-1
 2 235
35 GO:1904322 cellular response to forskolin 4.289E-3 2.287E-2
1.335E-1
8.234E-1
 1 10
36 GO:1904321 response to forskolin 4.289E-3 2.287E-2
1.335E-1
8.234E-1
 1 10
37 GO:0051924 regulation of calcium ion transport 4.508E-3 2.339E-2
1.366E-1
8.655E-1
 2 243
38 GO:0009152 purine ribonucleotide biosynthetic process 4.952E-3 2.487E-2
1.452E-1
9.509E-1
 2 255
39 GO:0001973 adenosine receptor signaling pathway 5.144E-3 2.487E-2
1.452E-1
9.877E-1
 1 12
40 GO:0006164 purine nucleotide biosynthetic process 5.182E-3 2.487E-2
1.452E-1
9.949E-1
 2 261
41 GO:0009260 ribonucleotide biosynthetic process 5.456E-3 2.525E-2
1.474E-1
1.000E0
 2 268
42 GO:0046390 ribose phosphate biosynthetic process 5.615E-3 2.525E-2
1.474E-1
1.000E0
 2 272
43 GO:0072522 purine-containing compound biosynthetic process 5.656E-3 2.525E-2
1.474E-1
1.000E0
 2 273
44 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 7.708E-3 2.968E-2
1.732E-1
1.000E0
 1 18
45 GO:1905145 cellular response to acetylcholine 7.708E-3 2.968E-2
1.732E-1
1.000E0
 1 18
46 GO:1903831 signal transduction involved in cellular response to ammonium ion 7.708E-3 2.968E-2
1.732E-1
1.000E0
 1 18
47 GO:1905144 response to acetylcholine 7.708E-3 2.968E-2
1.732E-1
1.000E0
 1 18
48 GO:0095500 acetylcholine receptor signaling pathway 7.708E-3 2.968E-2
1.732E-1
1.000E0
 1 18
49 GO:0098926 postsynaptic signal transduction 7.708E-3 2.968E-2
1.732E-1
1.000E0
 1 18
50 GO:0009165 nucleotide biosynthetic process 7.743E-3 2.968E-2
1.732E-1
1.000E0
 2 321
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005834 heterotrimeric G-protein complex 5.565E-19 1.558E-17 6.119E-17 1.558E-17 7 38
2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 1.146E-15 1.605E-14 6.301E-14 3.209E-14 7 107
3 GO:0019897 extrinsic component of plasma membrane 1.418E-14 1.323E-13 5.197E-13 3.970E-13 7 152
4 GO:0009898 cytoplasmic side of plasma membrane 3.019E-14 2.113E-13 8.299E-13 8.453E-13 7 169
5 GO:0098562 cytoplasmic side of membrane 5.528E-14 3.096E-13 1.216E-12 1.548E-12 7 184
6 GO:0019898 extrinsic component of membrane 1.029E-12 4.801E-12 1.886E-11 2.881E-11 7 278
7 GO:0030496 midbody 1.981E-5 7.925E-5 3.112E-4 5.547E-4 3 137
8 GO:0098857 membrane microdomain 3.025E-4 8.859E-4 3.479E-3 8.469E-3 3 343
9 GO:0045121 membrane raft 3.025E-4 8.859E-4 3.479E-3 8.469E-3 3 343
10 GO:0031526 brush border membrane 3.164E-4 8.859E-4 3.479E-3 8.859E-3 2 65
11 GO:0005903 brush border 1.239E-3 3.154E-3 1.239E-2 3.469E-2 2 129
12 GO:0098862 cluster of actin-based cell projections 2.263E-3 5.280E-3 2.074E-2
6.336E-2
 2 175
13 GO:0098852 lytic vacuole membrane 5.561E-3 1.112E-2 4.368E-2
1.557E-1
 2 277
14 GO:0005765 lysosomal membrane 5.561E-3 1.112E-2 4.368E-2
1.557E-1
 2 277
15 GO:0031253 cell projection membrane 7.902E-3 1.475E-2
5.792E-2
2.212E-1
 2 332
16 GO:0042588 zymogen granule 1.003E-2 1.691E-2
6.641E-2
2.809E-1
 1 24
17 GO:0005925 focal adhesion 1.094E-2 1.691E-2
6.641E-2
3.062E-1
 2 393
18 GO:0005924 cell-substrate adherens junction 1.120E-2 1.691E-2
6.641E-2
3.137E-1
 2 398
19 GO:0030055 cell-substrate junction 1.148E-2 1.691E-2
6.641E-2
3.213E-1
 2 403
20 GO:0005912 adherens junction 1.628E-2 2.279E-2
8.950E-2
4.558E-1
 2 484
21 GO:0043198 dendritic shaft 2.491E-2 3.321E-2
1.304E-1
6.975E-1
 1 60
Show 16 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 150 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004751 Paroxysmal ventricular tachycardia 6.373E-4 3.038E-2
1.699E-1
9.560E-2
 1 1
2 HP:0002116 Deficiency of speech development 1.119E-3 3.038E-2
1.699E-1
1.679E-1
 2 92
3 HP:0004451 Postauricular skin tag 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
4 HP:3000077 Abnormal mandible condylar process morphology 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
5 HP:0009902 Cleft helix 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
6 HP:0008537 Cleft at the superior portion of the pinna 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
7 HP:0005790 Short mandibular condyles 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
8 HP:0007628 Mandibular condyle hypoplasia 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
9 HP:0007627 Mandibular condyle aplasia 1.911E-3 3.038E-2
1.699E-1
2.867E-1
 1 3
10 HP:0009088 Speech articulation difficulties 2.548E-3 3.038E-2
1.699E-1
3.822E-1
 1 4
11 HP:0006936 Speech difficulties 2.548E-3 3.038E-2
1.699E-1
3.822E-1
 1 4
12 HP:0002399 Speech and language difficulties 2.548E-3 3.038E-2
1.699E-1
3.822E-1
 1 4
13 HP:0001345 Psychotic mentation 3.184E-3 3.038E-2
1.699E-1
4.776E-1
 1 5
14 HP:3000003 Abnormal mandibular ramus morphology 3.820E-3 3.038E-2
1.699E-1
5.730E-1
 1 6
15 HP:0003778 Short mandibular rami 3.820E-3 3.038E-2
1.699E-1
5.730E-1
 1 6
16 HP:0004453 Overfolding of the superior helices 3.820E-3 3.038E-2
1.699E-1
5.730E-1
 1 6
17 HP:0008231 Macronodular adrenal hyperplasia 3.820E-3 3.038E-2
1.699E-1
5.730E-1
 1 6
18 HP:0025267 Snoring 3.820E-3 3.038E-2
1.699E-1
5.730E-1
 1 6
19 HP:0009102 Anterior open-bite malocclusion 4.456E-3 3.038E-2
1.699E-1
6.684E-1
 1 7
20 HP:0008621 Hypoplastic pinna 4.456E-3 3.038E-2
1.699E-1
6.684E-1
 1 7
21 HP:0008559 Hypoplastic superior helix 4.456E-3 3.038E-2
1.699E-1
6.684E-1
 1 7
22 HP:0008589 Hypoplastic helices 4.456E-3 3.038E-2
1.699E-1
6.684E-1
 1 7
23 HP:0011763 Pituitary carcinoma 5.091E-3 3.320E-2
1.856E-1
7.637E-1
 1 8
24 HP:0001041 Facial erythema 5.726E-3 3.534E-2
1.976E-1
8.590E-1
 1 9
25 HP:0008291 Pituitary corticotropic cell adenoma 6.361E-3 3.534E-2
1.976E-1
9.542E-1
 1 10
26 HP:0005216 Impaired mastication 6.361E-3 3.534E-2
1.976E-1
9.542E-1
 1 10
27 HP:0011761 Pituitary null cell adenoma 6.361E-3 3.534E-2
1.976E-1
9.542E-1
 1 10
28 HP:0006767 Pituitary prolactin cell adenoma 6.996E-3 3.748E-2
2.095E-1
1.000E0
 1 11
29 HP:0010818 Generalized tonic seizures 7.630E-3 3.947E-2
2.207E-1
1.000E0
 1 12
30 HP:0012743 Abdominal obesity 8.264E-3 4.132E-2
2.310E-1
1.000E0
 1 13
31 HP:0003154 Increased circulating ACTH level 1.017E-2 4.919E-2
2.750E-1
1.000E0
 1 16
Show 26 more annotations

5: Mouse Phenotype [Display Chart] 8 input genes in category / 343 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004621 lumbar vertebral fusion 1.687E-7 5.787E-5 3.713E-4 5.787E-5 3 16
2 MP:0008687 increased interleukin-2 secretion 8.231E-6 1.093E-3 7.014E-3 2.823E-3 3 56
3 MP:0008568 abnormal interleukin secretion 1.215E-5 1.093E-3 7.014E-3 4.169E-3 5 495
4 MP:0009818 abnormal thromboxane level 1.459E-5 1.093E-3 7.014E-3 5.005E-3 2 8
5 MP:0009549 decreased platelet aggregation 1.688E-5 1.093E-3 7.014E-3 5.790E-3 3 71
6 MP:0008148 abnormal sternocostal joint morphology 1.912E-5 1.093E-3 7.014E-3 6.559E-3 3 74
7 MP:0009548 abnormal platelet aggregation 3.680E-5 1.644E-3 1.055E-2 1.262E-2 3 92
8 MP:0000154 rib fusion 4.181E-5 1.644E-3 1.055E-2 1.434E-2 3 96
9 MP:0006298 abnormal platelet activation 4.313E-5 1.644E-3 1.055E-2 1.479E-2 3 97
10 MP:0004625 abnormal rib joint morphology 6.810E-5 2.336E-3 1.499E-2 2.336E-2 3 113
11 MP:0008560 increased tumor necrosis factor secretion 8.147E-5 2.373E-3 1.522E-2 2.794E-2 3 120
12 MP:0003049 abnormal lumbar vertebrae morphology 9.201E-5 2.373E-3 1.522E-2 3.156E-2 3 125
13 MP:0005464 abnormal platelet physiology 9.647E-5 2.373E-3 1.522E-2 3.309E-2 3 127
14 MP:0008783 decreased B cell apoptosis 9.855E-5 2.373E-3 1.522E-2 3.380E-2 2 20
15 MP:0010082 sternebra fusion 1.089E-4 2.373E-3 1.522E-2 3.735E-2 2 21
16 MP:0008686 abnormal interleukin-2 secretion 1.107E-4 2.373E-3 1.522E-2 3.796E-2 3 133
17 MP:0030804 abnormal synovial joint morphology 1.373E-4 2.671E-3 1.714E-2 4.709E-2 3 143
18 MP:0005348 increased T cell proliferation 1.401E-4 2.671E-3 1.714E-2 4.807E-2 3 144
19 MP:0005617 increased susceptibility to type IV hypersensitivity reaction 1.553E-4 2.804E-3 1.799E-2
5.327E-2
 2 25
20 MP:0003026 decreased vasoconstriction 1.816E-4 3.114E-3 1.998E-2
6.228E-2
 2 27
21 MP:0004609 vertebral fusion 1.951E-4 3.187E-3 2.045E-2
6.692E-2
 3 161
22 MP:0003189 fused joints 2.413E-4 3.762E-3 2.414E-2
8.277E-2
 3 173
23 MP:0008177 increased germinal center B cell number 2.725E-4 4.064E-3 2.607E-2
9.347E-2
 2 33
24 MP:0000708 thymus hyperplasia 3.621E-4 5.175E-3 3.321E-2
1.242E-1
 2 38
25 MP:0008146 asymmetric sternocostal joints 4.015E-4 5.508E-3 3.534E-2
1.377E-1
 2 40
26 MP:0004803 increased susceptibility to autoimmune diabetes 4.642E-4 6.077E-3 3.899E-2
1.592E-1
 2 43
27 MP:0008102 lymph node hyperplasia 4.861E-4 6.077E-3 3.899E-2
1.667E-1
 2 44
28 MP:0000157 abnormal sternum morphology 5.230E-4 6.077E-3 3.899E-2
1.794E-1
 3 225
29 MP:0000459 abnormal presacral vertebrae morphology 5.298E-4 6.077E-3 3.899E-2
1.817E-1
 3 226
30 MP:0000740 impaired smooth muscle contractility 5.315E-4 6.077E-3 3.899E-2
1.823E-1
 2 46
31 MP:0000155 asymmetric rib joints 6.032E-4 6.527E-3 4.188E-2
2.069E-1
 2 49
32 MP:0008556 abnormal tumor necrosis factor secretion 6.089E-4 6.527E-3 4.188E-2
2.089E-1
 3 237
33 MP:0008661 decreased interleukin-10 secretion 7.057E-4 7.335E-3 4.706E-2
2.421E-1
 2 53
34 MP:0000250 abnormal vasoconstriction 8.742E-4 8.819E-3
5.659E-2
2.998E-1
 2 59
35 MP:0004322 abnormal sternebra morphology 9.650E-4 8.984E-3
5.764E-2
3.310E-1
 2 62
36 MP:0002551 abnormal blood coagulation 1.001E-3 8.984E-3
5.764E-2
3.432E-1
 3 281
37 MP:0000150 abnormal rib morphology 1.001E-3 8.984E-3
5.764E-2
3.432E-1
 3 281
38 MP:0004508 abnormal pectoral girdle bone morphology 1.001E-3 8.984E-3
5.764E-2
3.432E-1
 3 281
39 MP:0009676 abnormal hemostasis 1.021E-3 8.984E-3
5.764E-2
3.504E-1
 3 283
40 MP:0008176 abnormal germinal center B cell morphology 1.229E-3 1.028E-2
6.595E-2
4.214E-1
 2 70
41 MP:0013680 abnormal germinal center B cell number 1.229E-3 1.028E-2
6.595E-2
4.214E-1
 2 70
42 MP:0008781 abnormal B cell apoptosis 1.299E-3 1.061E-2
6.809E-2
4.457E-1
 2 72
43 MP:0005094 abnormal T cell proliferation 1.723E-3 1.374E-2
8.818E-2
5.910E-1
 3 339
44 MP:0008659 abnormal interleukin-10 secretion 1.934E-3 1.507E-2
9.672E-2
6.634E-1
 2 88
45 MP:0000709 enlarged thymus 1.978E-3 1.507E-2
9.672E-2
6.783E-1
 2 89
46 MP:0005606 increased bleeding time 2.066E-3 1.541E-2
9.887E-2
7.088E-1
 2 91
47 MP:0002534 abnormal type IV hypersensitivity reaction 2.250E-3 1.642E-2
1.053E-1
7.716E-1
 2 95
48 MP:0001828 abnormal T cell activation 2.375E-3 1.697E-2
1.089E-1
8.145E-1
 3 379
49 MP:0008182 decreased marginal zone B cell number 2.489E-3 1.742E-2
1.118E-1
8.538E-1
 2 100
50 MP:0002932 abnormal joint morphology 2.912E-3 1.998E-2
1.282E-1
9.988E-1
 3 407
Show 45 more annotations

6: Domain [Display Chart] 8 input genes in category / 30 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00275 G alpha SMART 5.697E-22 4.273E-21 1.707E-20 1.709E-20 7 16
2 PF00503 G-alpha Pfam 5.697E-22 4.273E-21 1.707E-20 1.709E-20 7 16
3 IPR011025 GproteinA insert InterPro 5.697E-22 4.273E-21 1.707E-20 1.709E-20 7 16
4 1.10.400.10 - Gene3D 5.697E-22 4.273E-21 1.707E-20 1.709E-20 7 16
5 IPR001019 Gprotein alpha su InterPro 9.685E-22 5.811E-21 2.322E-20 2.906E-20 7 17
6 IPR001408 Gprotein alpha I InterPro 1.631E-16 8.153E-16 3.257E-15 4.892E-15 5 8
7 IPR000469 Gprotein alpha 12/13 InterPro 1.596E-7 6.838E-7 2.732E-6 4.787E-6 2 2
8 PF00610 DEP Pfam 9.357E-3 2.668E-2
1.066E-1
2.807E-1
 1 22
9 PS50186 DEP PROSITE 9.357E-3 2.668E-2
1.066E-1
2.807E-1
 1 22
10 SM00049 DEP SMART 9.357E-3 2.668E-2
1.066E-1
2.807E-1
 1 22
11 IPR000591 DEP dom InterPro 9.781E-3 2.668E-2
1.066E-1
2.934E-1
 1 23
12 IPR001331 GDS CDC24 CS InterPro 1.654E-2 4.134E-2
1.651E-1
4.961E-1
 1 39
13 PS00741 DH 1 PROSITE 2.659E-2 4.987E-2
1.992E-1
7.978E-1
 1 63
14 SM00325 RhoGEF SMART 2.868E-2 4.987E-2
1.992E-1
8.603E-1
 1 68
15 PS50010 DH 2 PROSITE 2.951E-2 4.987E-2
1.992E-1
8.852E-1
 1 70
16 PF00621 RhoGEF Pfam 2.951E-2 4.987E-2
1.992E-1
8.852E-1
 1 70
17 IPR000219 DH-domain InterPro 2.992E-2 4.987E-2
1.992E-1
8.977E-1
 1 71
18 1.20.900.10 - Gene3D 2.992E-2 4.987E-2
1.992E-1
8.977E-1
 1 71
Show 13 more annotations

7: Pathway [Display Chart] 8 input genes in category / 122 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 138069 S1P4 pathway BioSystems: Pathway Interaction Database 2.988E-21 3.646E-19 1.963E-18 3.646E-19 7 14
2 137931 Sphingosine 1-phosphate (S1P) pathway BioSystems: Pathway Interaction Database 1.012E-19 6.170E-18 3.323E-17 1.235E-17 7 21
3 137982 S1P5 pathway BioSystems: Pathway Interaction Database 1.517E-19 6.170E-18 3.323E-17 1.851E-17 6 8
4 138059 S1P2 pathway BioSystems: Pathway Interaction Database 3.011E-19 9.184E-18 4.946E-17 3.674E-17 7 24
5 138063 S1P3 pathway BioSystems: Pathway Interaction Database 1.030E-18 2.513E-17 1.353E-16 1.256E-16 7 28
6 83086 Long-term depression BioSystems: KEGG 3.352E-16 6.815E-15 3.670E-14 4.089E-14 7 60
7 137928 LPA receptor mediated events BioSystems: Pathway Interaction Database 6.040E-16 1.053E-14 5.669E-14 7.369E-14 7 65
8 137937 S1P1 pathway BioSystems: Pathway Interaction Database 3.475E-13 5.300E-12 2.854E-11 4.240E-11 5 20
9 1269585 G-protein activation BioSystems: REACTOME 2.657E-12 3.602E-11 1.940E-10 3.242E-10 5 29
10 1383060 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding BioSystems: REACTOME 2.148E-11 2.620E-10 1.411E-9 2.620E-9 5 43
11 1269587 PLC beta mediated events BioSystems: REACTOME 3.420E-11 3.793E-10 2.043E-9 4.172E-9 5 47
12 1269586 G-protein mediated events BioSystems: REACTOME 3.817E-11 3.880E-10 2.090E-9 4.656E-9 5 48
13 1269584 Opioid Signalling BioSystems: REACTOME 7.257E-10 6.811E-9 3.668E-8 8.854E-8 5 85
14 1268694 Chaperonin-mediated protein folding BioSystems: REACTOME 1.578E-9 1.375E-8 7.405E-8 1.925E-7 5 99
15 1268693 Protein folding BioSystems: REACTOME 2.128E-9 1.731E-8 9.320E-8 2.596E-7 5 105
16 P05917 Opioid proopiomelanocortin pathway PantherDB 2.498E-9 1.792E-8 9.653E-8 3.047E-7 4 32
17 P05916 Opioid prodynorphin pathway PantherDB 2.498E-9 1.792E-8 9.653E-8 3.047E-7 4 32
18 P05913 Enkephalin release PantherDB 2.841E-9 1.824E-8 9.825E-8 3.467E-7 4 33
19 1269352 Signal amplification BioSystems: REACTOME 2.841E-9 1.824E-8 9.825E-8 3.467E-7 4 33
20 1144995 Sphingolipid signaling pathway BioSystems: KEGG 3.845E-9 2.346E-8 1.263E-7 4.691E-7 5 118
21 P00040 Metabotropic glutamate receptor group II pathway PantherDB 9.400E-9 5.461E-8 2.941E-7 1.147E-6 4 44
22 1269577 G alpha (z) signalling events BioSystems: REACTOME 1.346E-8 7.464E-8 4.019E-7 1.642E-6 4 48
23 P05912 Dopamine receptor mediated signaling pathway PantherDB 1.871E-8 9.872E-8 5.316E-7 2.282E-6 4 52
24 983748 cGMP-PKG signaling pathway BioSystems: KEGG 1.963E-8 9.872E-8 5.316E-7 2.395E-6 5 163
25 P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway PantherDB 2.023E-8 9.872E-8 5.316E-7 2.468E-6 4 53
26 1268817 Inhibition of adenylate cyclase pathway BioSystems: REACTOME 7.895E-8 3.568E-7 1.921E-6 9.632E-6 3 15
27 1268818 Adenylate cyclase inhibitory pathway BioSystems: REACTOME 7.895E-8 3.568E-7 1.921E-6 9.632E-6 3 15
28 377263 GABAergic synapse BioSystems: KEGG 1.596E-7 6.956E-7 3.746E-6 1.948E-5 4 88
29 552665 Morphine addiction BioSystems: KEGG 1.828E-7 7.691E-7 4.142E-6 2.231E-5 4 91
30 698773 Circadian entrainment BioSystems: KEGG 2.270E-7 9.229E-7 4.970E-6 2.769E-5 4 96
31 799177 Estrogen signaling pathway BioSystems: KEGG 2.467E-7 9.707E-7 5.228E-6 3.009E-5 4 98
32 537443 Retrograde endocannabinoid signaling BioSystems: KEGG 2.786E-7 1.030E-6 5.546E-6 3.399E-5 4 101
33 83092 Melanogenesis BioSystems: KEGG 2.786E-7 1.030E-6 5.546E-6 3.399E-5 4 101
34 147809 Chagas disease (American trypanosomiasis) BioSystems: KEGG 2.899E-7 1.039E-6 5.595E-6 3.536E-5 4 102
35 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 3.048E-7 1.039E-6 5.595E-6 3.719E-5 5 282
36 1269353 ADP signalling through P2Y purinoceptor 12 BioSystems: REACTOME 3.066E-7 1.039E-6 5.595E-6 3.740E-5 3 23
37 P05730 Endogenous cannabinoid signaling PantherDB 3.503E-7 1.155E-6 6.220E-6 4.273E-5 3 24
38 217716 Cholinergic synapse BioSystems: KEGG 4.226E-7 1.336E-6 7.194E-6 5.155E-5 4 112
39 169642 Toxoplasmosis BioSystems: KEGG 4.380E-7 1.336E-6 7.194E-6 5.343E-5 4 113
40 525336 Serotonergic synapse BioSystems: KEGG 4.380E-7 1.336E-6 7.194E-6 5.343E-5 4 113
41 213818 Glutamatergic synapse BioSystems: KEGG 4.538E-7 1.350E-6 7.271E-6 5.536E-5 4 114
42 952858 Platelet activation BioSystems: KEGG 6.159E-7 1.789E-6 9.635E-6 7.514E-5 4 123
43 469199 Dopaminergic synapse BioSystems: KEGG 7.692E-7 2.182E-6 1.175E-5 9.385E-5 4 130
44 P05915 Opioid proenkephalin pathway PantherDB 8.563E-7 2.374E-6 1.279E-5 1.045E-4 3 32
45 1492886 Apelin signaling pathway BioSystems: KEGG 9.774E-7 2.650E-6 1.427E-5 1.192E-4 4 138
46 1269575 G alpha (s) signalling events BioSystems: REACTOME 1.225E-6 3.196E-6 1.721E-5 1.494E-4 4 146
47 P05731 GABA-B receptor II signaling PantherDB 1.231E-6 3.196E-6 1.721E-5 1.502E-4 3 36
48 M3494 Thrombin signaling and protease-activated receptors MSigDB C2 BIOCARTA (v6.0) 1.339E-6 3.404E-6 1.833E-5 1.634E-4 3 37
49 952859 Oxytocin signaling pathway BioSystems: KEGG 1.477E-6 3.679E-6 1.981E-5 1.803E-4 4 153
50 83105 Pathways in cancer BioSystems: KEGG 1.623E-6 3.959E-6 2.132E-5 1.979E-4 5 395
Show 45 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 1011 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2508088 Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse. Pubmed 2.695E-25 2.725E-22 2.042E-21 2.725E-22 7 12
2 8858601 G protein gene expression during mouse oocyte growth and maturation, and preimplantation embryo development. Pubmed 4.027E-22 2.036E-19 1.526E-18 4.072E-19 7 28
3 8552586 The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. Pubmed 1.364E-21 4.598E-19 3.447E-18 1.379E-18 6 10
4 1302014 Evolution of the mammalian G protein alpha subunit multigene family. Pubmed 3.501E-21 8.849E-19 6.634E-18 3.540E-18 7 37
5 8986788 GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits. Pubmed 1.737E-18 3.512E-16 2.632E-15 1.756E-15 5 7
6 12509430 Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. Pubmed 4.631E-18 7.803E-16 5.850E-15 4.682E-15 5 8
7 8521505 The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Pubmed 2.084E-17 3.009E-15 2.256E-14 2.107E-14 5 10
8 16892066 Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Pubmed 1.064E-16 1.195E-14 8.959E-14 1.076E-13 5 13
9 8208289 Structural determinants for activation of the alpha-subunit of a heterotrimeric G protein. Pubmed 1.064E-16 1.195E-14 8.959E-14 1.076E-13 5 13
10 11118617 Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). Pubmed 2.482E-16 2.509E-14 1.881E-13 2.509E-13 5 15
11 11248120 Most central nervous system D2 dopamine receptors are coupled to their effectors by Go. Pubmed 7.897E-16 6.141E-14 4.604E-13 7.984E-13 4 4
12 11771389 Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins. Pubmed 7.897E-16 6.141E-14 4.604E-13 7.984E-13 4 4
13 18832081 The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics. Pubmed 7.897E-16 6.141E-14 4.604E-13 7.984E-13 4 4
14 2820999 Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium. Pubmed 3.948E-15 2.661E-13 1.995E-12 3.991E-12 4 5
15 12860983 Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor. Pubmed 3.948E-15 2.661E-13 1.995E-12 3.991E-12 4 5
16 11253162 Characterization of RGS5 in regulation of G protein-coupled receptor signaling. Pubmed 1.184E-14 7.043E-13 5.280E-12 1.197E-11 4 6
17 9647645 The mammalian calcium-binding protein, nucleobindin (CALNUC), is a Golgi resident protein. Pubmed 1.184E-14 7.043E-13 5.280E-12 1.197E-11 4 6
18 15251452 CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins. Pubmed 2.763E-14 1.552E-12 1.163E-11 2.794E-11 4 7
19 26755700 The LGN protein promotes planar proliferative divisions in the neocortex but apicobasal asymmetric terminal divisions in the retina. Pubmed 1.657E-13 8.378E-12 6.281E-11 1.676E-10 4 10
20 8588930 Analysis of G protein alpha subunit mRNA abundance in preimplantation mouse embryos using a rapid, quantitative RT-PCR approach. Pubmed 1.657E-13 8.378E-12 6.281E-11 1.676E-10 4 10
21 10926822 RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. Pubmed 3.906E-13 1.881E-11 1.410E-10 3.949E-10 4 12
22 2902634 Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Pubmed 1.077E-12 4.536E-11 3.401E-10 1.089E-9 4 15
23 7937899 Mechanism of GTP hydrolysis by G-protein alpha subunits. Pubmed 1.077E-12 4.536E-11 3.401E-10 1.089E-9 4 15
24 24478091 G proteins Gαi1/3 are critical targets for Bordetella pertussis toxin-induced vasoactive amine sensitization. Pubmed 1.077E-12 4.536E-11 3.401E-10 1.089E-9 4 15
25 29342363 Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
26 19401591 Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
27 17418106 Go but not Gi2 or Gi3 is required for muscarinic regulation of heart rate and heart rate variability in mice. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
28 16962188 Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
29 15788486 Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
30 18156202 G(o) controls the hyperpolarization-activated current in embryonic stem cell-derived cardiocytes. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
31 17484771 Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
32 23467353 Differential control of opioid antinociception to thermal stimuli in a knock-in mouse expressing regulator of G-protein signaling-insensitive Gαo protein. Pubmed 6.031E-12 1.906E-10 1.428E-9 6.098E-9 3 3
33 21931697 Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
34 11168387 CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
35 15488169 Analysis of RGSZ1 protein interaction with Galphai subunits. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
36 10364213 Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
37 17635935 Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
38 22706085 Defective macrophage migration in Gαi2- but not Gαi3-deficient mice. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
39 28145731 Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
40 18583341 Activation of Galpha (i) and subsequent uncoupling of receptor-Galpha(i) signaling by Pasteurella multocida toxin. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
41 1902575 Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
42 26373672 An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
43 12379657 Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
44 12297509 Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
45 11069896 Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors. Pubmed 2.412E-11 5.420E-10 4.063E-9 2.439E-8 3 4
46 10598579 Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins. Pubmed 6.030E-11 1.150E-9 8.623E-9 6.097E-8 3 5
47 9660808 Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane. Pubmed 6.030E-11 1.150E-9 8.623E-9 6.097E-8 3 5
48 12297512 Coordinated signaling through both G12/13 and G(i) pathways is sufficient to activate GPIIb/IIIa in human platelets. Pubmed 6.030E-11 1.150E-9 8.623E-9 6.097E-8 3 5
49 24415754 HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration. Pubmed 6.030E-11 1.150E-9 8.623E-9 6.097E-8 3 5
50 16298104 G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2). Pubmed 6.030E-11 1.150E-9 8.623E-9 6.097E-8 3 5
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 353 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TSHR TSHR interactions 3.982E-15 1.406E-12 9.059E-12 1.406E-12 6 43
2 int:GNG3 GNG3 interactions 1.687E-14 1.984E-12 1.279E-11 5.953E-12 5 16
3 int:RGS16 RGS16 interactions 1.687E-14 1.984E-12 1.279E-11 5.953E-12 5 16
4 int:RGS19 RGS19 interactions 1.298E-13 1.145E-11 7.382E-11 4.582E-11 5 23
5 int:RGS5 RGS5 interactions 1.197E-12 8.450E-11 5.446E-10 4.225E-10 4 8
6 int:NUCB1 NUCB1 interactions 3.702E-12 2.178E-10 1.404E-9 1.307E-9 5 43
7 int:RIC8A RIC8A interactions 6.581E-12 3.319E-10 2.139E-9 2.323E-9 5 48
8 int:RGS10 RGS10 interactions 1.221E-11 5.390E-10 3.474E-9 4.312E-9 4 13
9 int:RGS7 RGS7 interactions 3.107E-11 1.219E-9 7.855E-9 1.097E-8 4 16
10 int:NGB NGB interactions 5.223E-11 1.676E-9 1.080E-8 1.844E-8 4 18
11 int:GPSM2 GPSM2 interactions 5.223E-11 1.676E-9 1.080E-8 1.844E-8 4 18
12 int:RGS14 RGS14 interactions 8.266E-11 2.245E-9 1.447E-8 2.918E-8 4 20
13 int:GNG4 GNG4 interactions 8.266E-11 2.245E-9 1.447E-8 2.918E-8 4 20
14 int:RGS20 RGS20 interactions 1.181E-10 2.977E-9 1.919E-8 4.167E-8 5 84
15 int:OPRD1 OPRD1 interactions 2.990E-10 7.038E-9 4.536E-8 1.056E-7 4 27
16 int:GNAI1 GNAI1 interactions 3.339E-10 7.366E-9 4.747E-8 1.179E-7 5 103
17 int:PTPRU PTPRU interactions 4.046E-10 8.401E-9 5.414E-8 1.428E-7 4 29
18 int:DUSP22 DUSP22 interactions 4.663E-10 9.145E-9 5.894E-8 1.646E-7 5 110
19 int:GNB1 GNB1 interactions 1.005E-9 1.868E-8 1.204E-7 3.549E-7 5 128
20 int:DRD5 DRD5 interactions 1.211E-9 2.137E-8 1.377E-7 4.274E-7 3 6
21 int:S1PR4 S1PR4 interactions 2.118E-9 3.399E-8 2.191E-7 7.477E-7 3 7
22 int:RGS18 RGS18 interactions 2.118E-9 3.399E-8 2.191E-7 7.477E-7 3 7
23 int:CCR5 CCR5 interactions 2.531E-9 3.884E-8 2.503E-7 8.933E-7 4 45
24 int:S1PR5 S1PR5 interactions 7.258E-9 1.025E-7 6.605E-7 2.562E-6 3 10
25 int:CNR1 CNR1 interactions 7.258E-9 1.025E-7 6.605E-7 2.562E-6 3 10
26 int:GPSM3 GPSM3 interactions 9.977E-9 1.355E-7 8.731E-7 3.522E-6 3 11
27 int:GNAO1 GNAO1 interactions 1.377E-8 1.801E-7 1.161E-6 4.862E-6 4 68
28 int:ADORA1 ADORA1 interactions 1.729E-8 2.179E-7 1.405E-6 6.102E-6 3 13
29 int:RGS4 RGS4 interactions 2.749E-8 3.235E-7 2.085E-6 9.704E-6 3 15
30 int:ADRA2A ADRA2A interactions 2.749E-8 3.235E-7 2.085E-6 9.704E-6 3 15
31 int:GNG7 GNG7 interactions 3.383E-8 3.852E-7 2.483E-6 1.194E-5 3 16
32 int:PCP2 PCP2 interactions 4.107E-8 4.393E-7 2.831E-6 1.450E-5 3 17
33 int:GNG10 GNG10 interactions 4.107E-8 4.393E-7 2.831E-6 1.450E-5 3 17
34 int:RGS12 RGS12 interactions 5.850E-8 6.073E-7 3.914E-6 2.065E-5 3 19
35 int:GNAI3 GNAI3 interactions 1.080E-7 1.089E-6 7.021E-6 3.813E-5 4 113
36 int:NCF2 NCF2 interactions 1.763E-7 1.728E-6 1.114E-5 6.222E-5 3 27
37 int:TBXA2R TBXA2R interactions 2.707E-7 2.514E-6 1.620E-5 9.554E-5 3 31
38 int:F2R F2R interactions 2.707E-7 2.514E-6 1.620E-5 9.554E-5 3 31
39 int:S1PR1 S1PR1 interactions 2.986E-7 2.635E-6 1.698E-5 1.054E-4 3 32
40 int:GNB3 GNB3 interactions 2.986E-7 2.635E-6 1.698E-5 1.054E-4 3 32
41 int:GNG5 GNG5 interactions 3.284E-7 2.827E-6 1.822E-5 1.159E-4 3 33
42 int:GNAI2 GNAI2 interactions 3.376E-7 2.838E-6 1.829E-5 1.192E-4 4 150
43 int:DRD2 DRD2 interactions 4.295E-7 3.509E-6 2.261E-5 1.516E-4 3 36
44 int:MTNR1A MTNR1A interactions 4.374E-7 3.509E-6 2.261E-5 1.544E-4 4 160
45 int:GNG2 GNG2 interactions 6.405E-7 5.024E-6 3.238E-5 2.261E-4 3 41
46 int:AGAP2 AGAP2 interactions 9.264E-7 7.109E-6 4.582E-5 3.270E-4 4 193
47 int:HOXB5 HOXB5 interactions 1.572E-6 1.180E-5 7.608E-5 5.548E-4 3 55
48 int:HRH4 HRH4 interactions 1.786E-6 1.286E-5 8.291E-5 6.304E-4 2 5
49 int:S1PR3 S1PR3 interactions 1.786E-6 1.286E-5 8.291E-5 6.304E-4 2 5
50 int:CD81 CD81 interactions 2.284E-6 1.613E-5 1.039E-4 8.063E-4 4 242
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7p22.2 7p22.2 2.306E-3 8.475E-3 2.303E-2 1.845E-2 1 10
2 7q21 7q21 2.997E-3 8.475E-3 2.303E-2 2.397E-2 1 13
3 1p13 1p13 3.917E-3 8.475E-3 2.303E-2 3.134E-2 1 17
4 17q24.3 17q24.3 4.377E-3 8.475E-3 2.303E-2 3.502E-2 1 19
5 22q11.22 22q11.22 5.297E-3 8.475E-3 2.303E-2 4.237E-2 1 23
6 20q13.13 20q13.13 8.509E-3 9.724E-3 2.643E-2
6.807E-2
 1 37
7 16q13 16q13 8.509E-3 9.724E-3 2.643E-2
6.807E-2
 1 37
8 3p21.31 3p21.31 2.353E-2 2.353E-2
6.395E-2
1.882E-1
 1 103
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 108 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 1 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 722 Rho guanine nucleotide exchange factors genenames.org 3.628E-3 1.088E-2 1.995E-2 1.088E-2 1 66
2 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 8.354E-3 1.132E-2 2.076E-2 2.506E-2 1 152
3 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 1.132E-2 1.132E-2 2.076E-2 3.397E-2 1 206

13: Coexpression [Display Chart] 8 input genes in category / 827 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8430 Genes down-regulated in CD8 T cells: stem cell memory versus effector memory. MSigDB C7: Immunologic Signatures (v6.0) 3.400E-5 2.136E-2
1.558E-1
 2.812E-2 3 199
2 16790086-tableW1 Rat Liver Perez-Carreon06 290genes GeneSigDB 5.166E-5 2.136E-2
1.558E-1
 4.272E-2 3 229
3 M1433 Genes down-regulated during myeloid differentiation induced by tretinoin (ATRA) [PubChem=444795] and IL3 [GeneID=3652] in the EML cell line (myeloid progenitor). MSigDB C2: CGP Curated Gene Sets (v6.0) 9.825E-5 2.708E-2
1.976E-1
8.125E-2
 2 44

14: Coexpression Atlas [Display Chart] 8 input genes in category / 728 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC2 Top 200 Genes Kidney10XCellRanger Six2KI E14 Endo Endo Subtype E14-Six2KI-Endo-C13-KC2 Top 200 Genes 3.633E-6 2.645E-3 1.896E-2 2.645E-3 4 335
2 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid Tabula Muris Consortium 3.688E-5 1.343E-2
9.624E-2
 2.685E-2 3 193
3 gudmap developingGonad e11.5 ovary + mesonephros k2 500 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.492E-4 3.622E-2
2.596E-1
1.814E-1
 2 66
4 10X Human 68K PBMC Dendritic Subtype Dendritic-Dendritic c2 Top 200 Genes 10X Human 68K PBMC Dendritic Subtype Dendritic-Dendritic c2 Top 200 Genes 2.683E-4 3.622E-2
2.596E-1
1.953E-1
 3 377
5 gudmap developingGonad e12.5 testes k1 500 DevelopingGonad e12.5 testes emap-29069 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.846E-4 3.622E-2
2.596E-1
2.800E-1
 2 82
6 gudmap developingGonad e11.5 testes and mesonephros 500 DevelopingGonad e11.5 testes and mesonephros emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.085E-4 3.622E-2
2.596E-1
2.974E-1
 3 435
7 gudmap developingGonad e11.5 testes 500 DevelopingGonad e11.5 testes emap-3226 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.140E-4 3.622E-2
2.596E-1
3.014E-1
 3 437
8 gudmap developingGonad e14.5 testes 500 k5 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.489E-4 3.622E-2
2.596E-1
3.996E-1
 2 98
9 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Top 40 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hGaba Top 40 GSE76381_EmbryoMoleculeCountsPMLog2 6.908E-4 3.622E-2
2.596E-1
5.029E-1
 2 110
10 gudmap developingGonad P2 testes 500 k1 DevelopingGonad P2 testes emap-30171 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.076E-4 3.622E-2
2.596E-1
5.880E-1
 2 119
11 gudmap developingGonad e18.5 testes 500 k5 DevelopingGonad e18.5 testes emap-11164 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.334E-4 3.622E-2
2.596E-1
6.795E-1
 2 128
12 gudmap developingGonad e11.5 testes and mesonephros k3 500 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.037E-3 3.622E-2
2.596E-1
7.552E-1
 2 135
13 gudmap developingGonad P2 epididymis 1000 k1 DevelopingGonad P2 epididymis emap-30199 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.053E-3 3.622E-2
2.596E-1
7.664E-1
 2 136
14 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.1.5 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt mature-like mature-like Subtype M.1.5 Top 100 Genes 1.053E-3 3.622E-2
2.596E-1
7.664E-1
 2 136
15 Facebase ST1 e10.5 NeuroEpith FlankLateral 500 3 e10.5 NeuroEpith FlankLateral top-relative-expression-ranked 500 3 FaceBase_ST1 1.099E-3 3.622E-2
2.596E-1
8.001E-1
 1 3
16 gudmap developingKidney e15.5 1000 k1 DevelopingKidney e15.5 anlage of loop of Henle emap-31283 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.147E-3 3.622E-2
2.596E-1
8.348E-1
 2 142
17 gudmap developingGonad e11.5 testes k3 500 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.179E-3 3.622E-2
2.596E-1
8.583E-1
 2 144
18 gudmap developingGonad e12.5 ovary k4 1000 DevelopingGonad e12.5 ovary emap-28876 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.278E-3 3.622E-2
2.596E-1
9.305E-1
 2 150
19 gudmap developingGonad e11.5 ovary + mesonephros k4 1000 DevelopingGonad e11.5 ovary + mesonephros emap-3226 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.381E-3 3.622E-2
2.596E-1
1.000E0
 2 156
20 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 k2 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.399E-3 3.622E-2
2.596E-1
1.000E0
 2 157
21 gudmap developingGonad e12.5 testes k5 1000 DevelopingGonad e12.5 testes emap-29069 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.417E-3 3.622E-2
2.596E-1
1.000E0
 2 158
22 gudmap developingGonad e11.5 testes and mesonephros k4 1000 DevelopingGonad e11.5 testes and mesonephros emap-3226 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.525E-3 3.622E-2
2.596E-1
1.000E0
 2 164
23 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma TCGA-Bone and Soft Tissue 1.675E-3 3.622E-2
2.596E-1
1.000E0
 2 172
24 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal/IMM f Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Immune cells (IMM)/late fetal/IMM f Fetal, Development 1.831E-3 3.622E-2
2.596E-1
1.000E0
 1 5
25 gudmap developingGonad e14.5 testes 1000 k2 DevelopingGonad e14.5 testes emap-6710 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.853E-3 3.622E-2
2.596E-1
1.000E0
 2 181
26 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic A cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic A cell Tabula Muris Consortium 1.853E-3 3.622E-2
2.596E-1
1.000E0
 2 181
27 gudmap developingGonad e14.5 epididymis 1000 k2 DevelopingGonad e14.5 epididymis emap-29141 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.914E-3 3.622E-2
2.596E-1
1.000E0
 2 184
28 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hEndo Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hEndo Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 1.997E-3 3.622E-2
2.596E-1
1.000E0
 2 188
29 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hEndo Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hEndo Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.997E-3 3.622E-2
2.596E-1
1.000E0
 2 188
30 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Overall Top 200 Genes 2.060E-3 3.622E-2
2.596E-1
1.000E0
 2 191
31 10X Human 68K PBMC CD14+ Monocyte Overall Top 200 Genes 10X Human 68K PBMC CD14+ Monocyte Overall Top 200 Genes 2.081E-3 3.622E-2
2.596E-1
1.000E0
 2 192
32 Glioblastoma Single Cell Merged Immune cell Overall Top 200 Genes Glioblastoma Single Cell Merged Immune cell Overall Top 200 Genes 2.103E-3 3.622E-2
2.596E-1
1.000E0
 2 193
33 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney NephrogenicRest Wilms EN-A/Kidney NephrogenicRest Wilms EN2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-A/Kidney NephrogenicRest Wilms EN-A/Kidney NephrogenicRest Wilms EN2 Adult, Development, and Cancer types 2.103E-3 3.622E-2
2.596E-1
1.000E0
 2 193
34 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Top 200 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Top 200 2.124E-3 3.622E-2
2.596E-1
1.000E0
 2 194
35 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Overall Top 200 Genes 10X Human 8K PBMC Dendritic cells (S100A9, S100A8, LYZ) Overall Top 200 Genes 2.124E-3 3.622E-2
2.596E-1
1.000E0
 2 194
36 10X Human 8K PBMC Myeloid Overall Top 200 Genes 10X Human 8K PBMC Myeloid Overall Top 200 Genes 2.146E-3 3.622E-2
2.596E-1
1.000E0
 2 195
37 10X Human 8K PBMC Dendritic cells (FCGR3A, RHOC, MS4A7) Top 200 10X Human 8K PBMC Dendritic cells (FCGR3A, RHOC, MS4A7) Top 200 2.146E-3 3.622E-2
2.596E-1
1.000E0
 2 195
38 10X Human 68K PBMC Dendritic Overall Top 200 Genes 10X Human 68K PBMC Dendritic Overall Top 200 Genes 2.146E-3 3.622E-2
2.596E-1
1.000E0
 2 195
39 10X Human 8K PBMC Dendritic cells (FCGR3A, RHOC, MS4A7) Overall Top 200 Genes 10X Human 8K PBMC Dendritic cells (FCGR3A, RHOC, MS4A7) Overall Top 200 Genes 2.146E-3 3.622E-2
2.596E-1
1.000E0
 2 195
40 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte Tabula Muris Consortium 2.167E-3 3.622E-2
2.596E-1
1.000E0
 2 196
41 10X Human 8K PBMC Dendritic cells (FCER1A, HLA-DPA1, HLA-DRB5) Overall Top 200 Genes 10X Human 8K PBMC Dendritic cells (FCER1A, HLA-DPA1, HLA-DRB5) Overall Top 200 Genes 2.189E-3 3.622E-2
2.596E-1
1.000E0
 2 197
42 Immune cells (IMM)/Immune cells (IMM) f Immune cells (IMM)/Immune cells (IMM) f 2.189E-3 3.622E-2
2.596E-1
1.000E0
 2 197
43 gudmap developingGonad e11.5 testes k2 1000 DevelopingGonad e11.5 testes emap-3226 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.189E-3 3.622E-2
2.596E-1
1.000E0
 2 197
44 Immune cells (IMM) Immune cells (IMM) 2.189E-3 3.622E-2
2.596E-1
1.000E0
 2 197
45 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.459E-3 3.892E-2
2.790E-1
1.000E0
 2 209
46 Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-B Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-B Lungmap CCHMC 2.459E-3 3.892E-2
2.790E-1
1.000E0
 2 209
47 Sample Type by Project: Shred 1/TCGA-B cell/Diffuse large B-cell lymphoma /DLBCL/3 Sample Type by Project: Shred 1/TCGA-B cell/Diffuse large B-cell lymphoma /DLBCL/3 TCGA-B cell 2.563E-3 3.943E-2
2.827E-1
1.000E0
 1 7
48 Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-D Lungmap Mouse Lung PND1 Endothelial Subtype Vascular Endothelial-D Lungmap CCHMC 2.600E-3 3.943E-2
2.827E-1
1.000E0
 2 215
49 Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Neutrophil Top 200 Genes Human Cell Atlas Human Cell Atlas Myeloid Myeloid Subtype Neutrophil Top 200 Genes 3.280E-3 4.796E-2
3.438E-1
1.000E0
 2 242
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Medulla Wilms U U/Kidney Normal-Medulla Wilms U22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Medulla Wilms U U/Kidney Normal-Medulla Wilms U22 Adult, Development, and Cancer types 3.294E-3 4.796E-2
3.438E-1
1.000E0
 1 9
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 30 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5631 MODULE 87 Genes in the cancer module 87. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.335E-6 1.301E-4 5.196E-4 1.301E-4 3 44
2 M12584 MODULE 289 Genes in the cancer module 289. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.851E-5 1.478E-3 5.903E-3 2.955E-3 3 124
3 M13751 MODULE 123 Genes in the cancer module 123. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.524E-4 7.524E-3 3.006E-2 2.257E-2 3 247
4 M18480 MODULE 159 Translation regulation. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.745E-3 1.309E-2
5.229E-2
5.236E-2
 2 81

16: MicroRNA [Display Chart] 8 input genes in category / 326 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 AAGCACA,MIR-218:MSigDB AAGCACA,MIR-218:MSigDB MSigDB 7.322E-6 1.129E-3 7.188E-3 2.387E-3 3 370
2 CTTTGTA,MIR-524:MSigDB CTTTGTA,MIR-524:MSigDB MSigDB 9.878E-6 1.129E-3 7.188E-3 3.220E-3 3 409
3 hsa-miR-30b-5p:Functional MTI Functional MTI miRTarbase 1.039E-5 1.129E-3 7.188E-3 3.388E-3 3 416
4 hsa-miR-411-5p.1:TargetScan hsa-miR-411-5p.1 TargetScan 4.470E-5 3.643E-3 2.319E-2 1.457E-2 2 92
5 hsa-miR-1231:PITA hsa-miR-1231:PITA TOP PITA 1.205E-4 7.858E-3
5.002E-2
 3.929E-2 2 151
6 hsa-miR-1307:mirSVR lowEffct hsa-miR-1307:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.808E-4 9.823E-3
6.253E-2
5.894E-2
 2 185
7 hsa-miR-222:PITA hsa-miR-222:PITA TOP PITA 3.839E-4 1.421E-2
9.045E-2
1.252E-1
 2 270
8 hsa-miR-221:PITA hsa-miR-221:PITA TOP PITA 3.925E-4 1.421E-2
9.045E-2
1.279E-1
 2 273
9 hsa-miR-624:PITA hsa-miR-624:PITA TOP PITA 4.011E-4 1.421E-2
9.045E-2
1.308E-1
 2 276
10 hsa-miR-23b-3p:Functional MTI Functional MTI miRTarbase 5.448E-4 1.421E-2
9.045E-2
1.776E-1
 2 322
11 hsa-miR-30e-5p:Functional MTI Functional MTI miRTarbase 6.320E-4 1.421E-2
9.045E-2
2.060E-1
 2 347
12 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 6.612E-4 1.421E-2
9.045E-2
2.156E-1
 2 355
13 hsa-miR-129-1-3p:TargetScan hsa-miR-129-1-3p TargetScan 6.686E-4 1.421E-2
9.045E-2
2.180E-1
 2 357
14 hsa-miR-129-2-3p:TargetScan hsa-miR-129-2-3p TargetScan 6.686E-4 1.421E-2
9.045E-2
2.180E-1
 2 357
15 hsa-miR-30d-5p:Functional MTI Functional MTI miRTarbase 7.101E-4 1.421E-2
9.045E-2
2.315E-1
 2 368
16 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 7.410E-4 1.421E-2
9.045E-2
2.416E-1
 2 376
17 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 7.410E-4 1.421E-2
9.045E-2
2.416E-1
 2 376
18 hsa-miR-222-3p:Functional MTI Functional MTI miRTarbase 8.129E-4 1.462E-2
9.304E-2
2.650E-1
 2 394
19 hsa-miR-450a-5p:TargetScan hsa-miR-450a-5p TargetScan 8.856E-4 1.462E-2
9.304E-2
2.887E-1
 1 8
20 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 8.967E-4 1.462E-2
9.304E-2
2.923E-1
 2 414
21 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.002E-3 1.468E-2
9.348E-2
3.268E-1
 2 438
22 hsa-miR-3124:mirSVR highEffct hsa-miR-3124:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.107E-3 1.468E-2
9.348E-2
3.609E-1
 1 10
23 hsa-miR-320c:PITA hsa-miR-320c:PITA TOP PITA 1.206E-3 1.468E-2
9.348E-2
3.933E-1
 2 481
24 hsa-miR-320d:PITA hsa-miR-320d:PITA TOP PITA 1.206E-3 1.468E-2
9.348E-2
3.933E-1
 2 481
25 hsa-miR-320a:PITA hsa-miR-320a:PITA TOP PITA 1.206E-3 1.468E-2
9.348E-2
3.933E-1
 2 481
26 hsa-miR-320b:PITA hsa-miR-320b:PITA TOP PITA 1.206E-3 1.468E-2
9.348E-2
3.933E-1
 2 481
27 hsa-miR-539:PITA hsa-miR-539:PITA TOP PITA 1.216E-3 1.468E-2
9.348E-2
3.965E-1
 2 483
28 hsa-miR-1306:PITA hsa-miR-1306:PITA TOP PITA 2.544E-3 2.962E-2
1.886E-1
8.294E-1
 1 23
29 hsa-miR-126-3p.1:TargetScan hsa-miR-126-3p.1 TargetScan 2.655E-3 2.984E-2
1.900E-1
8.655E-1
 1 24
30 hsa-miR-323b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.876E-3 3.125E-2
1.989E-1
9.375E-1
 1 26
31 hsa-miR-410-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.986E-3 3.140E-2
1.999E-1
9.735E-1
 1 27
32 hsa-miR-494-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.097E-3 3.155E-2
2.008E-1
1.000E0
 1 28
33 hsa-miR-1277:PITA hsa-miR-1277:PITA TOP PITA 3.318E-3 3.277E-2
2.086E-1
1.000E0
 1 30
34 hsa-miR-409-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.428E-3 3.287E-2
2.092E-1
1.000E0
 1 31
35 hsa-miR-7152-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 3.604E-2
2.294E-1
1.000E0
 1 35
36 hsa-miR-219b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.201E-3 3.804E-2
2.421E-1
1.000E0
 1 38
37 hsa-miR-6772-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 3.809E-2
2.425E-1
1.000E0
 1 42
38 CAGTCAC,MIR-134:MSigDB CAGTCAC,MIR-134:MSigDB MSigDB 5.193E-3 3.809E-2
2.425E-1
1.000E0
 1 47
39 GCTGAGT,MIR-512-5P:MSigDB GCTGAGT,MIR-512-5P:MSigDB MSigDB 5.414E-3 3.809E-2
2.425E-1
1.000E0
 1 49
40 hsa-miR-3960:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.809E-2
2.425E-1
1.000E0
 1 54
41 hsa-miR-8072:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.965E-3 3.809E-2
2.425E-1
1.000E0
 1 54
42 hsa-miR-885-3p:PITA hsa-miR-885-3p:PITA TOP PITA 6.075E-3 3.809E-2
2.425E-1
1.000E0
 1 55
43 hsa-miR-3145-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.185E-3 3.809E-2
2.425E-1
1.000E0
 1 56
44 hsa-miR-3937:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.515E-3 3.809E-2
2.425E-1
1.000E0
 1 59
45 CTAGGAA,MIR-384:MSigDB CTAGGAA,MIR-384:MSigDB MSigDB 6.625E-3 3.809E-2
2.425E-1
1.000E0
 1 60
46 hsa-miR-138-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.736E-3 3.809E-2
2.425E-1
1.000E0
 1 61
47 hsa-miR-4258:mirSVR highEffct hsa-miR-4258:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.846E-3 3.809E-2
2.425E-1
1.000E0
 1 62
48 hsa-miR-92b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.846E-3 3.809E-2
2.425E-1
1.000E0
 1 62
49 hsa-miR-3134:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 3.809E-2
2.425E-1
1.000E0
 1 63
50 AAGTCCA,MIR-422A:MSigDB AAGTCCA,MIR-422A:MSigDB MSigDB 7.066E-3 3.809E-2
2.425E-1
1.000E0
 1 64
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 1553 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011957432 Gi-2 Stitch 9.896E-12 1.537E-8 1.218E-7 1.537E-8 6 195
2 ctd:D006143 Guanabenz CTD 3.380E-9 2.625E-6 2.080E-5 5.249E-6 3 10
3 ctd:D012110 Reserpine CTD 4.824E-8 2.497E-5 1.979E-4 7.492E-5 4 119
4 CID011957431 GI-1 Stitch 7.553E-8 2.932E-5 2.324E-4 1.173E-4 4 133
5 CID000024546 magnesium fluoride Stitch 6.552E-7 1.627E-4 1.290E-3 1.018E-3 3 53
6 CID000004016 NSC-351907 Stitch 6.676E-7 1.627E-4 1.290E-3 1.037E-3 4 229
7 CID000133014 alpha-methylhomocysteine-thiolactone Stitch 7.335E-7 1.627E-4 1.290E-3 1.139E-3 3 55
8 CID000002124 aluminum fluoride Stitch 1.250E-6 2.427E-4 1.924E-3 1.942E-3 4 268
9 ctd:D006220 Haloperidol CTD 3.374E-6 5.823E-4 4.615E-3 5.240E-3 4 344
10 ctd:D002713 Chlorine CTD 4.409E-6 6.848E-4 5.427E-3 6.848E-3 4 368
11 ctd:D003024 Clozapine CTD 5.663E-6 7.996E-4 6.337E-3 8.795E-3 4 392
12 CID000000807 iodine Stitch 8.783E-6 1.137E-3 9.008E-3 1.364E-2 3 125
13 CID011957433 GI-3 Stitch 1.428E-5 1.615E-3 1.280E-2 2.218E-2 3 147
14 ctd:D004155 Diphenhydramine CTD 1.456E-5 1.615E-3 1.280E-2 2.261E-2 2 17
15 CID000123651 hp 5B Stitch 1.830E-5 1.889E-3 1.497E-2 2.842E-2 2 19
16 CID000643998 GDP-b-S Stitch 1.946E-5 1.889E-3 1.497E-2 3.023E-2 3 163
17 CID000056801 salmeterol xinafoate Stitch 2.706E-5 2.412E-3 1.912E-2 4.202E-2 2 23
18 CID000104727 aluminum Stitch 2.796E-5 2.412E-3 1.912E-2 4.342E-2 3 184
19 CID000259185 NSC400385 Stitch 3.474E-5 2.840E-3 2.250E-2
5.395E-2
 2 26
20 ctd:C520612 N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid CTD 6.350E-5 4.931E-3 3.908E-2
9.862E-2
 2 35
21 CID005289342 SC45647 Stitch 7.105E-5 5.255E-3 4.165E-2
1.103E-1
 2 37
22 CID000014917 fluoride Stitch 9.547E-5 6.739E-3
5.341E-2
1.483E-1
 3 278
23 CID000002049 tyrphostin AG1296 Stitch 1.008E-4 6.806E-3
5.394E-2
1.565E-1
 2 44
24 ctd:D003000 Clonidine CTD 1.579E-4 1.022E-2
8.099E-2
2.453E-1
 2 55
25 ctd:D030421 Peroxynitrous Acid CTD 1.757E-4 1.091E-2
8.651E-2
2.729E-1
 2 58
26 ctd:D026423 S-Nitroso-N-Acetylpenicillamine CTD 2.141E-4 1.279E-2
1.013E-1
3.324E-1
 2 64
27 CID000003987 oleoyl-lysophosphatidic acid Stitch 2.635E-4 1.516E-2
1.201E-1
4.092E-1
 3 392
28 ctd:D014527 Uric Acid CTD 3.181E-4 1.764E-2
1.398E-1
4.940E-1
 2 78
29 CID005317848 4-guanidino-1-butanol Stitch 3.502E-4 1.876E-2
1.487E-1
5.439E-1
 1 1
30 ctd:C097284 manganese(III)-tetrakis(4-benzoic acid)porphyrin CTD 3.689E-4 1.909E-2
1.513E-1
5.728E-1
 2 84
31 ctd:D002112 Calcifediol CTD 4.328E-4 2.168E-2
1.718E-1
6.721E-1
 2 91
32 ctd:D010852 Picrotoxin CTD 4.715E-4 2.288E-2
1.814E-1
7.323E-1
 2 95
33 ctd:D009599 Nitroprusside CTD 6.429E-4 3.026E-2
2.398E-1
9.985E-1
 2 111
34 ctd:C007517 diphenyleneiodonium CTD 6.898E-4 3.028E-2
2.399E-1
1.000E0
 2 115
35 CID000023039 Alstonine hydrochloride Stitch 7.018E-4 3.028E-2
2.399E-1
1.000E0
 2 116
36 ctd:D010424 Pentobarbital CTD 7.018E-4 3.028E-2
2.399E-1
1.000E0
 2 116
37 CID006326976 diphosphonic acid Stitch 1.050E-3 3.641E-2
2.886E-1
1.000E0
 1 3
38 CID006398525 Sulcrate Stitch 1.138E-3 3.641E-2
2.886E-1
1.000E0
 2 148
39 ctd:C080703 SK&F 83959 CTD 1.231E-3 3.641E-2
2.886E-1
1.000E0
 2 154
40 ctd:D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine CTD 1.378E-3 3.641E-2
2.886E-1
1.000E0
 2 163
41 ctd:D024502 alpha-Tocopherol CTD 1.463E-3 3.641E-2
2.886E-1
1.000E0
 2 168
42 CID000446755 P-NE Stitch 1.480E-3 3.641E-2
2.886E-1
1.000E0
 2 169
43 ctd:D017974 Uranium Compounds CTD 1.585E-3 3.641E-2
2.886E-1
1.000E0
 2 175
44 2410 UP Perhexiline maleate [6724-53-4]; Up 200; 10.2uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.676E-3 3.641E-2
2.886E-1
1.000E0
 2 180
45 CID000125992 ethoxy idazoxan Stitch 1.750E-3 3.641E-2
2.886E-1
1.000E0
 1 5
46 606 DN (+/-)-thalidomide; Down 200; 100uM; MCF7; HG-U133A Broad Institute CMAP Down 1.943E-3 3.641E-2
2.886E-1
1.000E0
 2 194
47 2293 DN Griseofulvin [126-07-8]; Down 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.943E-3 3.641E-2
2.886E-1
1.000E0
 2 194
48 3943 DN Methyl benzethonium chloride [25155-18-4]; Down 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.943E-3 3.641E-2
2.886E-1
1.000E0
 2 194
49 5313 UP Hesperidin [520-26-3]; Up 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.963E-3 3.641E-2
2.886E-1
1.000E0
 2 195
50 1419 UP Oxolinic acid [14698-29-4]; Up 200; 15.4uM; HL60; HG-U133A Broad Institute CMAP Up 1.963E-3 3.641E-2
2.886E-1
1.000E0
 2 195
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 159 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0002622 Amnesia DisGeNET Curated 2.686E-4 5.606E-3 3.167E-2 4.271E-2 2 51
2 C0038587 Substance Withdrawal Syndrome DisGeNET Curated 3.358E-4 5.606E-3 3.167E-2
5.339E-2
 2 57
3 OMIN:603483 EUKARYOTIC TRANSLATION INITIATION FACTOR 4E-BINDING PROTEIN 3; EIF4EBP3 OMIM 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
4 C0030591 Paroxysmal ventricular tachycardia DisGeNET Curated 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
5 cv:CN180194 Early infantile epileptic encephalopathy 17 Clinical Variations 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
6 cv:C0340485 Familial ventricular tachycardia Clinical Variations 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
7 C4025323 Postauricular skin tag DisGeNET Curated 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
8 cv:C1865295 Auriculocondylar syndrome 1 Clinical Variations 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
9 C3809606 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 17 DisGeNET Curated 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
10 OMIN:192605 VENTRICULAR TACHYCARDIA, FAMILIAL OMIM 4.937E-4 5.606E-3 3.167E-2
7.849E-2
 1 1
11 C4280432 Failure of development of condylar head of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
12 C4280435 Absence of the condylar process of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
13 C4280430 Failure of development of the condylar process of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
14 C4280429 Underdevelopment of condylar neck of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
15 C4280436 Absence of the condylar neck of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
16 C4280434 Agenesis of condylar head of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
17 C4280426 Hypotrophic condylar process of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
18 C4280423 Small condylar neck of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
19 C4280425 Hypotrophic mandibular condyle DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
20 C4280424 Small condylar head of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
21 C4280433 Agenesis of condylar neck of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
22 C4280428 Hypoplasia of condylar head of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
23 C0399572 Hypoplasia of mandibular condyle DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
24 C4280431 Failure of development of condylar neck of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
25 C1865302 Cleft at the superior portion of the pinna DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
26 C4280437 Absence of the condylar head of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
27 C4280427 Hypoplasia of condylar neck of mandible DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
28 C0399570 Mandibular condyle aplasia DisGeNET Curated 9.871E-4 5.606E-3 3.167E-2
1.570E-1
 1 2
29 C0037672 Somnambulism DisGeNET BeFree 1.480E-3 7.356E-3 4.155E-2
2.354E-1
 1 3
30 C0239043 Difficulty chewing DisGeNET Curated 1.480E-3 7.356E-3 4.155E-2
2.354E-1
 1 3
31 C1865313 Speech articulation difficulties DisGeNET Curated 1.480E-3 7.356E-3 4.155E-2
2.354E-1
 1 3
32 C0340485 Familial ventricular tachycardia DisGeNET Curated 1.480E-3 7.356E-3 4.155E-2
2.354E-1
 1 3
33 C1865305 Hypoplastic superior helix DisGeNET Curated 1.973E-3 8.965E-3
5.065E-2
3.138E-1
 1 4
34 C1865304 Overfolding of the superior helices DisGeNET Curated 1.973E-3 8.965E-3
5.065E-2
3.138E-1
 1 4
35 C4024598 Anterior open-bite malocclusion DisGeNET Curated 1.973E-3 8.965E-3
5.065E-2
3.138E-1
 1 4
36 20081125:Gudbjartsson Height GWAS 2.120E-3 9.363E-3
5.290E-2
3.371E-1
 2 144
37 C0264478 Sequoiosis DisGeNET BeFree 2.466E-3 1.032E-2
5.830E-2
3.921E-1
 1 5
38 C0030508 Parasomnia DisGeNET BeFree 2.466E-3 1.032E-2
5.830E-2
3.921E-1
 1 5
39 C1836508 Hypertonic seizures DisGeNET Curated 3.943E-3 1.552E-2
8.767E-2
6.270E-1
 1 8
40 C1865295 Auriculo-condylar syndrome DisGeNET Curated 3.943E-3 1.552E-2
8.767E-2
6.270E-1
 1 8
41 C0553665 Skin endocrine disorder DisGeNET BeFree 4.002E-3 1.552E-2
8.767E-2
6.363E-1
 2 199
42 C1827301 Extensively Drug-Resistant Tuberculosis DisGeNET BeFree 4.927E-3 1.822E-2
1.029E-1
7.834E-1
 1 10
43 C0268575 Isovaleryl-CoA dehydrogenase deficiency DisGeNET Curated 4.927E-3 1.822E-2
1.029E-1
7.834E-1
 1 10
44 C0007570 Celiac Disease DisGeNET Curated 6.098E-3 2.204E-2
1.245E-1
9.696E-1
 2 247
45 C2931919 X-linked infantile spasm syndrome DisGeNET BeFree 6.401E-3 2.262E-2
1.278E-1
1.000E0
 1 13
46 C0947785 [D]Sleep disturbances (& [hypersomnia] or [insomnia]) DisGeNET BeFree 6.892E-3 2.382E-2
1.346E-1
1.000E0
 1 14
47 C0427086 Involuntary Movements DisGeNET BeFree 7.383E-3 2.498E-2
1.411E-1
1.000E0
 1 15
48 C0024586 Malignant Carcinoid Syndrome DisGeNET Curated 7.873E-3 2.557E-2
1.445E-1
1.000E0
 1 16
49 20081125:Levy Blood pressure GWAS 8.364E-3 2.557E-2
1.445E-1
1.000E0
 1 17
50 C0014742 Erythema Multiforme DisGeNET Curated 8.364E-3 2.557E-2
1.445E-1
1.000E0
 1 17
Show 45 more annotations