Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc114_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 58 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0036310 annealing helicase activity 5.781E-6 1.534E-4 7.129E-4 3.353E-4 2 8
2 GO:0048256 flap endonuclease activity 5.781E-6 1.534E-4 7.129E-4 3.353E-4 2 8
3 GO:0004520 endodeoxyribonuclease activity 1.017E-5 1.534E-4 7.129E-4 5.900E-4 3 94
4 GO:0097617 annealing activity 1.361E-5 1.534E-4 7.129E-4 7.895E-4 2 12
5 GO:0003697 single-stranded DNA binding 1.379E-5 1.534E-4 7.129E-4 7.996E-4 3 104
6 GO:0004536 deoxyribonuclease activity 1.587E-5 1.534E-4 7.129E-4 9.206E-4 3 109
7 GO:0004519 endonuclease activity 5.684E-5 4.471E-4 2.078E-3 3.297E-3 3 167
8 GO:0000217 DNA secondary structure binding 6.167E-5 4.471E-4 2.078E-3 3.577E-3 2 25
9 GO:0004518 nuclease activity 1.470E-4 9.471E-4 4.400E-3 8.524E-3 3 230
10 GO:0051908 double-stranded DNA 5'-3' exodeoxyribonuclease activity 4.823E-4 2.797E-3 1.300E-2 2.797E-2 1 1
11 GO:0008094 DNA-dependent ATPase activity 8.646E-4 4.239E-3 1.969E-2
5.015E-2
 2 93
12 GO:0045145 single-stranded DNA 5'-3' exodeoxyribonuclease activity 9.644E-4 4.239E-3 1.969E-2
5.593E-2
 1 2
13 GO:0048257 3'-flap endonuclease activity 9.644E-4 4.239E-3 1.969E-2
5.593E-2
 1 2
14 GO:0016887 ATPase activity 1.023E-3 4.239E-3 1.969E-2
5.934E-2
 3 446
15 GO:0003917 DNA topoisomerase type I activity 1.928E-3 6.989E-3 3.247E-2
1.118E-1
 1 4
16 GO:0008309 double-stranded DNA exodeoxyribonuclease activity 1.928E-3 6.989E-3 3.247E-2
1.118E-1
 1 4
17 GO:0009378 four-way junction helicase activity 2.409E-3 7.822E-3 3.634E-2
1.397E-1
 1 5
18 GO:0008297 single-stranded DNA exodeoxyribonuclease activity 2.891E-3 7.822E-3 3.634E-2
1.677E-1
 1 6
19 GO:0051880 G-quadruplex DNA binding 2.891E-3 7.822E-3 3.634E-2
1.677E-1
 1 6
20 GO:0035312 5'-3' exodeoxyribonuclease activity 2.891E-3 7.822E-3 3.634E-2
1.677E-1
 1 6
21 GO:0004386 helicase activity 2.914E-3 7.822E-3 3.634E-2
1.690E-1
 2 172
22 GO:0019237 centromeric DNA binding 3.372E-3 7.822E-3 3.634E-2
1.956E-1
 1 7
23 GO:0003696 satellite DNA binding 3.372E-3 7.822E-3 3.634E-2
1.956E-1
 1 7
24 GO:0043140 ATP-dependent 3'-5' DNA helicase activity 3.372E-3 7.822E-3 3.634E-2
1.956E-1
 1 7
25 GO:0000405 bubble DNA binding 3.372E-3 7.822E-3 3.634E-2
1.956E-1
 1 7
26 GO:0008821 crossover junction endodeoxyribonuclease activity 3.853E-3 7.980E-3 3.708E-2
2.234E-1
 1 8
27 GO:0003916 DNA topoisomerase activity 3.853E-3 7.980E-3 3.708E-2
2.234E-1
 1 8
28 GO:0000150 recombinase activity 3.853E-3 7.980E-3 3.708E-2
2.234E-1
 1 8
29 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters 4.814E-3 9.627E-3 4.473E-2
2.792E-1
 1 10
30 GO:0030983 mismatched DNA binding 5.774E-3 1.099E-2
5.107E-2
3.349E-1
 1 12
31 GO:0043138 3'-5' DNA helicase activity 6.254E-3 1.099E-2
5.107E-2
3.627E-1
 1 13
32 GO:0070182 DNA polymerase binding 6.254E-3 1.099E-2
5.107E-2
3.627E-1
 1 13
33 GO:0004523 RNA-DNA hybrid ribonuclease activity 6.254E-3 1.099E-2
5.107E-2
3.627E-1
 1 13
34 GO:0043142 single-stranded DNA-dependent ATPase activity 6.733E-3 1.149E-2
5.337E-2
3.905E-1
 1 14
35 GO:0000400 four-way junction DNA binding 7.692E-3 1.275E-2
5.922E-2
4.461E-1
 1 16
36 GO:0004529 exodeoxyribonuclease activity 8.650E-3 1.320E-2
6.134E-2
5.017E-1
 1 18
37 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 8.650E-3 1.320E-2
6.134E-2
5.017E-1
 1 18
38 GO:0008409 5'-3' exonuclease activity 8.650E-3 1.320E-2
6.134E-2
5.017E-1
 1 18
39 GO:0016894 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 9.607E-3 1.429E-2
6.638E-2
5.572E-1
 1 20
40 GO:0042623 ATPase activity, coupled 1.046E-2 1.517E-2
7.047E-2
6.067E-1
 2 332
41 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters 1.771E-2 2.505E-2
1.164E-1
1.000E0
 1 37
42 GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.245E-2 3.021E-2
1.404E-1
1.000E0
 1 47
43 GO:0004003 ATP-dependent DNA helicase activity 2.245E-2 3.021E-2
1.404E-1
1.000E0
 1 47
44 GO:0016796 exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters 2.292E-2 3.021E-2
1.404E-1
1.000E0
 1 48
45 GO:0044824 retroviral 3' processing activity 2.575E-2 3.111E-2
1.446E-1
1.000E0
 1 54
46 GO:0044823 retroviral integrase activity 2.575E-2 3.111E-2
1.446E-1
1.000E0
 1 54
47 GO:0008907 integrase activity 2.575E-2 3.111E-2
1.446E-1
1.000E0
 1 54
48 GO:0043765 T/G mismatch-specific endonuclease activity 2.575E-2 3.111E-2
1.446E-1
1.000E0
 1 54
49 GO:0004521 endoribonuclease activity 2.716E-2 3.215E-2
1.494E-1
1.000E0
 1 57
50 GO:0003678 DNA helicase activity 3.092E-2 3.587E-2
1.667E-1
1.000E0
 1 65
Show 45 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 233 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006310 DNA recombination 2.238E-17 5.214E-15 3.144E-14 5.214E-15 9 267
2 GO:0000732 strand displacement 4.426E-13 5.156E-11 3.109E-10 1.031E-10 5 26
3 GO:0000731 DNA synthesis involved in DNA repair 1.151E-10 8.940E-9 5.391E-8 2.682E-8 5 75
4 GO:0071897 DNA biosynthetic process 2.162E-8 1.260E-6 7.596E-6 5.039E-6 5 211
5 GO:0051321 meiotic cell cycle 3.868E-8 1.803E-6 1.087E-5 9.013E-6 5 237
6 GO:0000724 double-strand break repair via homologous recombination 7.204E-8 2.504E-6 1.510E-5 1.678E-5 4 93
7 GO:0000725 recombinational repair 7.522E-8 2.504E-6 1.510E-5 1.753E-5 4 94
8 GO:0006260 DNA replication 2.549E-7 7.425E-6 4.478E-5 5.940E-5 5 346
9 GO:0072757 cellular response to camptothecin 6.227E-7 1.612E-5 9.721E-5 1.451E-4 2 3
10 GO:1901796 regulation of signal transduction by p53 class mediator 7.589E-7 1.768E-5 1.066E-4 1.768E-4 4 167
11 GO:1901563 response to camptothecin 1.245E-6 2.579E-5 1.555E-4 2.901E-4 2 4
12 GO:1903046 meiotic cell cycle process 1.410E-6 2.579E-5 1.555E-4 3.285E-4 4 195
13 GO:0006302 double-strand break repair 1.439E-6 2.579E-5 1.555E-4 3.352E-4 4 196
14 GO:0072710 response to hydroxyurea 3.111E-6 4.833E-5 2.914E-4 7.249E-4 2 6
15 GO:0072711 cellular response to hydroxyurea 3.111E-6 4.833E-5 2.914E-4 7.249E-4 2 6
16 GO:0072331 signal transduction by p53 class mediator 4.633E-6 6.747E-5 4.069E-4 1.080E-3 4 263
17 GO:0000733 DNA strand renaturation 7.461E-6 9.150E-5 5.518E-4 1.738E-3 2 9
18 GO:0045003 double-strand break repair via synthesis-dependent strand annealing 7.461E-6 9.150E-5 5.518E-4 1.738E-3 2 9
19 GO:0000730 DNA recombinase assembly 7.461E-6 9.150E-5 5.518E-4 1.738E-3 2 9
20 GO:0000729 DNA double-strand break processing 4.339E-5 4.814E-4 2.903E-3 1.011E-2 2 21
21 GO:0031297 replication fork processing 4.339E-5 4.814E-4 2.903E-3 1.011E-2 2 21
22 GO:0010212 response to ionizing radiation 4.757E-5 5.038E-4 3.038E-3 1.108E-2 3 157
23 GO:0045005 DNA-dependent DNA replication maintenance of fidelity 5.699E-5 5.773E-4 3.481E-3 1.328E-2 2 24
24 GO:0010165 response to X-ray 1.088E-4 1.056E-3 6.368E-3 2.534E-2 2 33
25 GO:0006298 mismatch repair 1.225E-4 1.142E-3 6.886E-3 2.855E-2 2 35
26 GO:0071312 cellular response to alkaloid 1.297E-4 1.162E-3 7.008E-3 3.022E-2 2 36
27 GO:0007131 reciprocal meiotic recombination 2.033E-4 1.634E-3 9.852E-3 4.738E-2 2 45
28 GO:0035825 homologous recombination 2.033E-4 1.634E-3 9.852E-3 4.738E-2 2 45
29 GO:0006312 mitotic recombination 2.033E-4 1.634E-3 9.852E-3 4.738E-2 2 45
30 GO:0071103 DNA conformation change 2.783E-4 2.161E-3 1.303E-2
6.483E-2
 3 285
31 GO:0071479 cellular response to ionizing radiation 3.384E-4 2.464E-3 1.486E-2
7.885E-2
 2 58
32 GO:0070192 chromosome organization involved in meiotic cell cycle 3.384E-4 2.464E-3 1.486E-2
7.885E-2
 2 58
33 GO:0000018 regulation of DNA recombination 3.867E-4 2.731E-3 1.647E-2
9.011E-2
 2 62
34 GO:1902521 response to etoposide 4.833E-4 3.217E-3 1.940E-2
1.126E-1
 1 1
35 GO:1990414 replication-born double-strand break repair via sister chromatid exchange 4.833E-4 3.217E-3 1.940E-2
1.126E-1
 1 1
36 GO:0032508 DNA duplex unwinding 5.808E-4 3.706E-3 2.235E-2
1.353E-1
 2 76
37 GO:0051052 regulation of DNA metabolic process 5.884E-4 3.706E-3 2.235E-2
1.371E-1
 3 368
38 GO:0006282 regulation of DNA repair 6.274E-4 3.847E-3 2.320E-2
1.462E-1
 2 79
39 GO:0032392 DNA geometric change 6.595E-4 3.940E-3 2.376E-2
1.537E-1
 2 81
40 GO:1904631 response to glucoside 9.663E-4 5.492E-3 3.312E-2
2.252E-1
 1 2
41 GO:1990426 mitotic recombination-dependent replication fork processing 9.663E-4 5.492E-3 3.312E-2
2.252E-1
 1 2
42 GO:0007127 meiosis I 1.063E-3 5.899E-3 3.557E-2
2.478E-1
 2 103
43 GO:0009314 response to radiation 1.273E-3 6.898E-3 4.160E-2
2.966E-1
 3 480
44 GO:0045950 negative regulation of mitotic recombination 1.449E-3 7.504E-3 4.525E-2
3.377E-1
 1 3
45 GO:2000819 regulation of nucleotide-excision repair 1.449E-3 7.504E-3 4.525E-2
3.377E-1
 1 3
46 GO:0006261 DNA-dependent DNA replication 1.790E-3 8.700E-3
5.246E-2
4.170E-1
 2 134
47 GO:0002023 reduction of food intake in response to dietary excess 1.932E-3 8.700E-3
5.246E-2
4.501E-1
 1 4
48 GO:0051106 positive regulation of DNA ligation 1.932E-3 8.700E-3
5.246E-2
4.501E-1
 1 4
49 GO:0072719 cellular response to cisplatin 1.932E-3 8.700E-3
5.246E-2
4.501E-1
 1 4
50 GO:0072429 response to intra-S DNA damage checkpoint signaling 1.932E-3 8.700E-3
5.246E-2
4.501E-1
 1 4
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000795 synaptonemal complex 6.596E-7 1.451E-5 5.356E-5 1.451E-5 3 39
2 GO:0000794 condensed nuclear chromosome 1.050E-5 8.184E-5 3.021E-4 2.309E-4 3 97
3 GO:0016605 PML body 1.116E-5 8.184E-5 3.021E-4 2.455E-4 3 99
4 GO:0000800 lateral element 1.798E-5 9.890E-5 3.650E-4 3.956E-4 2 14
5 GO:0001673 male germ cell nucleus 4.142E-5 1.823E-4 6.727E-4 9.113E-4 2 21
6 GO:0043073 germ cell nucleus 6.914E-5 2.535E-4 9.356E-4 1.521E-3 2 27
7 GO:0000793 condensed chromosome 1.025E-4 3.221E-4 1.189E-3 2.255E-3 3 208
8 GO:0016604 nuclear body 5.326E-4 1.465E-3 5.406E-3 1.172E-2 3 364
9 GO:0005712 chiasma 1.887E-3 4.614E-3 1.703E-2 4.152E-2 1 4
10 GO:0048476 Holliday junction resolvase complex 2.359E-3 4.970E-3 1.834E-2
5.189E-2
 1 5
11 GO:0000781 chromosome, telomeric region 2.485E-3 4.970E-3 1.834E-2
5.467E-2
 2 162
12 GO:0032300 mismatch repair complex 7.062E-3 1.295E-2 4.778E-2
1.554E-1
 1 15
13 GO:0045120 pronucleus 9.874E-3 1.671E-2
6.167E-2
2.172E-1
 1 21
14 GO:0098687 chromosomal region 1.075E-2 1.689E-2
6.236E-2
2.365E-1
 2 344
15 GO:0035861 site of double-strand break 1.548E-2 2.270E-2
8.378E-2
3.405E-1
 1 33
16 GO:1990391 DNA repair complex 2.152E-2 2.958E-2
1.092E-1
4.733E-1
 1 46
17 GO:0005657 replication fork 3.120E-2 4.038E-2
1.490E-1
6.864E-1
 1 67
Show 12 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 635 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0002860 Squamous cell carcinoma 6.274E-6 3.984E-3 2.801E-2 3.984E-3 4 237
2 HP:0007378 Neoplasm of the gastrointestinal tract 3.483E-5 1.106E-2
7.777E-2
 2.212E-2 4 363
3 HP:0001402 Hepatocellular carcinoma 8.260E-5 1.302E-2
9.156E-2
5.245E-2
 3 131
4 HP:0100615 Ovarian neoplasm 9.867E-5 1.302E-2
9.156E-2
6.266E-2
 3 139
5 HP:0008069 Neoplasm of the skin 1.025E-4 1.302E-2
9.156E-2
6.511E-2
 4 475
6 HP:0031105 Abnormal uterus morphology 1.867E-4 1.659E-2
1.167E-1
1.186E-1
 3 172
7 HP:0002896 Neoplasm of the liver 1.933E-4 1.659E-2
1.167E-1
1.227E-1
 3 174
8 HP:0100650 Vaginal neoplasm 2.338E-4 1.659E-2
1.167E-1
1.485E-1
 2 30
9 HP:0011133 Increased sensitivity to ionizing radiation 2.664E-4 1.659E-2
1.167E-1
1.692E-1
 2 32
10 HP:0003254 Abnormality of DNA repair 3.012E-4 1.659E-2
1.167E-1
1.912E-1
 2 34
11 HP:0010785 Gonadal neoplasm 3.153E-4 1.659E-2
1.167E-1
2.002E-1
 3 205
12 HP:0003002 Breast carcinoma 3.584E-4 1.659E-2
1.167E-1
2.276E-1
 3 214
13 HP:0010623 Tumours of the breast 3.634E-4 1.659E-2
1.167E-1
2.308E-1
 3 215
14 HP:0002488 Acute leukemia 3.839E-4 1.659E-2
1.167E-1
2.438E-1
 3 219
15 HP:0100013 Neoplasm of the breast 3.945E-4 1.659E-2
1.167E-1
2.505E-1
 3 221
16 HP:0011018 Abnormality of the cell cycle 4.180E-4 1.659E-2
1.167E-1
2.654E-1
 2 40
17 HP:0010787 Genital neoplasm 5.042E-4 1.883E-2
1.324E-1
3.201E-1
 3 240
18 HP:0001009 Telangiectasia 5.558E-4 1.961E-2
1.379E-1
3.529E-1
 3 248
19 HP:0000130 Abnormality of the uterus 6.107E-4 2.041E-2
1.435E-1
3.878E-1
 3 256
20 HP:0003220 Abnormality of chromosome stability 6.812E-4 2.163E-2
1.521E-1
4.325E-1
 2 51
21 HP:0002898 Embryonal neoplasm 7.231E-4 2.187E-2
1.538E-1
4.592E-1
 3 271
22 HP:0000137 Abnormality of the ovary 8.396E-4 2.339E-2
1.645E-1
5.331E-1
 3 285
23 HP:0010614 Fibroma 8.661E-4 2.339E-2
1.645E-1
5.499E-1
 3 288
24 HP:0012316 Fibrous tissue neoplasm 8.840E-4 2.339E-2
1.645E-1
5.613E-1
 3 290
25 HP:0007379 Neoplasm of the genitourinary tract 1.216E-3 2.939E-2
2.067E-1
7.721E-1
 3 323
26 HP:0001875 Neutropenia 1.227E-3 2.939E-2
2.067E-1
7.792E-1
 3 324
27 HP:0011991 Abnormal neutrophil count 1.250E-3 2.939E-2
2.067E-1
7.935E-1
 3 326
28 HP:0030448 Soft tissue sarcoma 1.515E-3 3.303E-2
2.322E-1
9.623E-1
 3 348
29 HP:0002916 Abnormality of chromosome segregation 1.633E-3 3.303E-2
2.322E-1
1.000E0
 2 79
30 HP:0000789 Infertility 1.661E-3 3.303E-2
2.322E-1
1.000E0
 3 359
31 HP:0005598 Facial telangiectasia in butterfly midface distribution 1.699E-3 3.303E-2
2.322E-1
1.000E0
 1 2
32 HP:0030063 Neuroepithelial neoplasm 1.730E-3 3.303E-2
2.322E-1
1.000E0
 3 364
33 HP:0030060 Nervous tissue neoplasm 1.772E-3 3.303E-2
2.322E-1
1.000E0
 3 367
34 HP:0030061 Neuroectodermal neoplasm 1.772E-3 3.303E-2
2.322E-1
1.000E0
 3 367
35 HP:0000144 Decreased fertility 2.010E-3 3.303E-2
2.322E-1
1.000E0
 3 383
36 HP:0005368 Abnormality of humoral immunity 2.010E-3 3.303E-2
2.322E-1
1.000E0
 3 383
37 HP:0100787 Prostate neoplasm 2.024E-3 3.303E-2
2.322E-1
1.000E0
 2 88
38 HP:0003003 Colon cancer 2.024E-3 3.303E-2
2.322E-1
1.000E0
 2 88
39 HP:0002846 Abnormal B cell morphology 2.104E-3 3.303E-2
2.322E-1
1.000E0
 3 389
40 HP:0001874 Abnormality of neutrophils 2.136E-3 3.303E-2
2.322E-1
1.000E0
 3 391
41 HP:0001882 Leukopenia 2.184E-3 3.303E-2
2.322E-1
1.000E0
 3 394
42 HP:0100608 Metrorrhagia 2.184E-3 3.303E-2
2.322E-1
1.000E0
 3 394
43 HP:0010784 Uterine neoplasm 2.307E-3 3.406E-2
2.395E-1
1.000E0
 2 94
44 HP:0100273 Neoplasm of the colon 2.505E-3 3.517E-2
2.473E-1
1.000E0
 2 98
45 HP:0000957 Cafe-au-lait spot 2.505E-3 3.517E-2
2.473E-1
1.000E0
 2 98
46 HP:0005585 Spotty hyperpigmentation 2.548E-3 3.517E-2
2.473E-1
1.000E0
 1 3
47 HP:0100242 Sarcoma 2.636E-3 3.561E-2
2.504E-1
1.000E0
 3 420
48 HP:0001824 Weight loss 2.729E-3 3.583E-2
2.520E-1
1.000E0
 3 425
49 HP:0100031 Neoplasm of the thyroid gland 2.765E-3 3.583E-2
2.520E-1
1.000E0
 2 103
50 HP:0031093 Abnormal breast morphology 3.082E-3 3.791E-2
2.665E-1
1.000E0
 3 443
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 9 input genes in category / 206 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0012431 increased lymphoma incidence 4.106E-5 6.396E-3 3.779E-2 8.459E-3 4 255
2 MP:0010296 increased hemolymphoid system tumor incidence 8.272E-5 6.396E-3 3.779E-2 1.704E-2 4 305
3 MP:0008866 chromosomal instability 1.182E-4 6.396E-3 3.779E-2 2.435E-2 3 119
4 MP:0010094 abnormal chromosome stability 1.242E-4 6.396E-3 3.779E-2 2.559E-2 3 121
5 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality 1.572E-4 6.478E-3 3.827E-2 3.239E-2 3 131
6 MP:0009765 abnormal xenobiotic induced morbidity/mortality 3.455E-4 9.257E-3
5.468E-2
7.117E-2
 3 171
7 MP:0001658 increased mortality induced by gamma-irradiation 3.937E-4 9.257E-3
5.468E-2
8.110E-2
 2 35
8 MP:0008943 increased sensitivity to induced cell death 4.150E-4 9.257E-3
5.468E-2
8.549E-2
 3 182
9 MP:0010383 increased adenoma incidence 4.423E-4 9.257E-3
5.468E-2
9.112E-2
 3 186
10 MP:0020189 abnormal adenoma incidence 4.493E-4 9.257E-3
5.468E-2
9.257E-2
 3 187
11 MP:0003992 increased mortality induced by ionizing radiation 8.050E-4 1.485E-2
8.773E-2
1.658E-1
 2 50
12 MP:0020149 abnormal mortality induced by ionizing radiation 9.043E-4 1.485E-2
8.773E-2
1.863E-1
 2 53
13 MP:0002007 increased cellular sensitivity to gamma-irradiation 9.737E-4 1.485E-2
8.773E-2
2.006E-1
 2 55
14 MP:0012734 abnormal response to radiation 1.009E-3 1.485E-2
8.773E-2
2.079E-1
 2 56
15 MP:0008942 abnormal induced cell death 1.111E-3 1.525E-2
9.011E-2
2.288E-1
 3 255
16 MP:0004966 abnormal inner cell mass proliferation 1.485E-3 1.884E-2
1.113E-1
3.059E-1
 2 68
17 MP:0004028 chromosome breakage 1.663E-3 1.884E-2
1.113E-1
3.426E-1
 2 72
18 MP:0009564 abnormal meiotic configurations 1.738E-3 1.884E-2
1.113E-1
3.579E-1
 1 2
19 MP:0008967 absent chiasmata formation 1.738E-3 1.884E-2
1.113E-1
3.579E-1
 1 2
20 MP:0003702 abnormal chromosome morphology 2.049E-3 2.110E-2
1.247E-1
4.220E-1
 2 80
21 MP:0004227 increased cellular sensitivity to ionizing radiation 2.151E-3 2.110E-2
1.247E-1
4.431E-1
 2 82
22 MP:0009763 increased sensitivity to induced morbidity/mortality 2.718E-3 2.470E-2
1.459E-1
5.599E-1
 3 348
23 MP:0004816 abnormal class switch recombination 2.757E-3 2.470E-2
1.459E-1
5.680E-1
 2 93
24 MP:0012142 absent amniotic cavity 3.473E-3 2.981E-2
1.761E-1
7.153E-1
 1 4
25 MP:0002018 increased malignant tumor incidence 3.841E-3 3.165E-2
1.870E-1
7.913E-1
 3 393
26 MP:0010470 ascending aorta dilation 4.339E-3 3.438E-2
2.031E-1
8.938E-1
 1 5
27 MP:0008058 abnormal DNA repair 4.923E-3 3.756E-2
2.219E-1
1.000E0
 2 125
28 MP:0006265 increased pulse pressure 5.205E-3 3.829E-2
2.262E-1
1.000E0
 1 6
29 MP:0003882 abnormal pulse pressure 6.070E-3 4.186E-2
2.473E-1
1.000E0
 1 7
30 MP:0020148 abnormal sensitivity to induced morbidity/mortality 6.096E-3 4.186E-2
2.473E-1
1.000E0
 3 463
31 MP:0001931 abnormal oogenesis 7.668E-3 4.868E-2
2.876E-1
1.000E0
 2 157
32 MP:0009797 abnormal mismatch repair 7.798E-3 4.868E-2
2.876E-1
1.000E0
 1 9
33 MP:0009871 abnormal aorta tunica adventitia morphology 7.798E-3 4.868E-2
2.876E-1
1.000E0
 1 9
Show 28 more annotations

6: Domain [Display Chart] 9 input genes in category / 129 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR003583 Hlx-hairpin-Hlx DNA-bd motif InterPro 4.303E-6 2.775E-4 1.510E-3 5.550E-4 2 7
2 SM00278 HhH1 SMART 4.303E-6 2.775E-4 1.510E-3 5.550E-4 2 7
3 IPR032199 RMI1 C InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
4 PF01396 zf-C4 Topoisom Pfam 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
5 IPR011941 DNA recomb/repair Rad51 InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
6 IPR033472 DUF1767 InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
7 IPR032641 Exo1 InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
8 SM01161 DUF1767 SMART 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
9 IPR012532 BDHCT InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
10 IPR013498 Topo IA Znf InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
11 PF08072 BDHCT Pfam 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
12 IPR004585 DNA recomb/repair Rad52 InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
13 IPR033309 Mus81 InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
14 IPR028830 Mlh3 InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
15 PF16099 RMI1 C Pfam 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
16 IPR032439 BDHCT assoc InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
17 IPR032437 BLM N InterPro 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
18 PF16202 BLM N Pfam 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
19 PF16204 BDHCT assoc Pfam 4.804E-4 2.950E-3 1.605E-2
6.197E-2
 1 1
20 IPR027420 PolB N InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
21 PF01131 Topoisom bac Pfam 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
22 PF08585 RMI1 N Pfam 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
23 2.70.20.10 - Gene3D 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
24 IPR007232 Rad52 Rad59 Rad22 InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
25 PS50163 RECA 3 PROSITE 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
26 IPR003601 Topo IA 2 InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
27 IPR013824 Topo IA cen sub1 InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
28 SM00436 TOP1Bc SMART 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
29 3.40.50.140 - Gene3D 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
30 SM00956 RQC SMART 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
31 IPR013894 RMI1 N InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
32 IPR023406 Topo IA AS InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
33 IPR013497 Topo IA cen InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
34 1.10.460.10 - Gene3D 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
35 SM00437 TOP1Ac SMART 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
36 IPR003602 Topo IA DNA-bd dom InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
37 1.10.8.310 - Gene3D 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
38 IPR023405 Topo IA core domain InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
39 PF04098 Rad52 Rad22 Pfam 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
40 SM00493 TOPRIM SMART 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
41 IPR000380 Topo IA InterPro 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
42 PS00396 TOPOISOMERASE I PROK PROSITE 9.606E-4 2.950E-3 1.605E-2
1.239E-1
 1 2
43 SM00490 HELICc SMART 1.133E-3 2.950E-3 1.605E-2
1.462E-1
 2 107
44 PF00271 Helicase C Pfam 1.133E-3 2.950E-3 1.605E-2
1.462E-1
 2 107
45 IPR001650 Helicase C InterPro 1.154E-3 2.950E-3 1.605E-2
1.489E-1
 2 108
46 PS51194 HELICASE CTER PROSITE 1.176E-3 2.950E-3 1.605E-2
1.517E-1
 2 109
47 PS51192 HELICASE ATP BIND 1 PROSITE 1.176E-3 2.950E-3 1.605E-2
1.517E-1
 2 109
48 SM00487 DEXDc SMART 1.176E-3 2.950E-3 1.605E-2
1.517E-1
 2 109
49 IPR014001 Helicase ATP-bd InterPro 1.197E-3 2.950E-3 1.605E-2
1.544E-1
 2 110
50 PF08676 MutL C Pfam 1.441E-3 2.950E-3 1.605E-2
1.858E-1
 1 3
Show 45 more annotations

7: Pathway [Display Chart] 9 input genes in category / 38 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1309106 Resolution of D-loop Structures through Holliday Junction Intermediates BioSystems: REACTOME 2.623E-14 5.648E-13 2.388E-12 9.969E-13 6 35
2 1309105 Resolution of D-Loop Structures BioSystems: REACTOME 3.148E-14 5.648E-13 2.388E-12 1.196E-12 6 36
3 1309108 HDR through Single Strand Annealing (SSA) BioSystems: REACTOME 4.459E-14 5.648E-13 2.388E-12 1.695E-12 6 38
4 83046 Homologous recombination BioSystems: KEGG 7.258E-14 6.895E-13 2.915E-12 2.758E-12 6 41
5 1309100 HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) BioSystems: REACTOME 5.054E-13 3.841E-12 1.624E-11 1.920E-11 7 134
6 1309099 Homology Directed Repair BioSystems: REACTOME 6.909E-13 4.376E-12 1.850E-11 2.625E-11 7 140
7 1309102 HDR through Homologous Recombination (HRR) BioSystems: REACTOME 1.924E-12 1.044E-11 4.416E-11 7.311E-11 6 69
8 1309095 DNA Double-Strand Break Repair BioSystems: REACTOME 2.639E-12 1.254E-11 5.300E-11 1.003E-10 7 169
9 1309107 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BioSystems: REACTOME 4.060E-12 1.714E-11 7.248E-11 1.543E-10 5 27
10 1309104 Presynaptic phase of homologous DNA pairing and strand exchange BioSystems: REACTOME 3.298E-11 1.253E-10 5.298E-10 1.253E-9 5 40
11 1309103 Homologous DNA Pairing and Strand Exchange BioSystems: REACTOME 4.820E-11 1.665E-10 7.040E-10 1.832E-9 5 43
12 377262 Fanconi anemia pathway BioSystems: KEGG 1.736E-10 5.499E-10 2.325E-9 6.598E-9 5 55
13 1270350 DNA Repair BioSystems: REACTOME 2.341E-10 6.842E-10 2.893E-9 8.894E-9 7 319
14 1269866 Meiotic recombination BioSystems: REACTOME 2.992E-7 8.120E-7 3.433E-6 1.137E-5 4 89
15 1383080 Regulation of TP53 Activity through Phosphorylation BioSystems: REACTOME 3.573E-7 9.051E-7 3.827E-6 1.358E-5 4 93
16 1269754 G2/M DNA damage checkpoint BioSystems: REACTOME 4.061E-7 9.645E-7 4.078E-6 1.543E-5 4 96
17 1309101 Processing of DNA double-strand break ends BioSystems: REACTOME 4.597E-7 1.028E-6 4.345E-6 1.747E-5 4 99
18 1269865 Meiosis BioSystems: REACTOME 1.065E-6 2.248E-6 9.504E-6 4.046E-5 4 122
19 1383076 Regulation of TP53 Activity BioSystems: REACTOME 3.308E-6 6.617E-6 2.797E-5 1.257E-4 4 162
20 1269753 G2/M Checkpoints BioSystems: REACTOME 4.200E-6 7.979E-6 3.374E-5 1.596E-4 4 172
21 1269742 Cell Cycle Checkpoints BioSystems: REACTOME 8.270E-6 1.496E-5 6.327E-5 3.143E-4 4 204
22 1269654 Transcriptional Regulation by TP53 BioSystems: REACTOME 8.958E-5 1.547E-4 6.542E-4 3.404E-3 4 374
23 83045 Mismatch repair BioSystems: KEGG 1.166E-4 1.927E-4 8.145E-4 4.431E-3 2 23
24 PW:0000662 mismatch repair pathway Pathway Ontology 1.496E-4 2.369E-4 1.002E-3 5.686E-3 2 26
25 1268744 SUMOylation of DNA damage response and repair proteins BioSystems: REACTOME 1.356E-3 2.061E-3 8.713E-3
5.152E-2
 2 78
26 PW:0000098 DNA replication Pathway Ontology 1.445E-3 2.112E-3 8.931E-3
5.492E-2
 1 2
27 1268743 SUMO E3 ligases SUMOylate target proteins BioSystems: REACTOME 2.395E-3 3.370E-3 1.425E-2
9.100E-2
 2 104
28 1268738 SUMOylation BioSystems: REACTOME 2.674E-3 3.629E-3 1.535E-2
1.016E-1
 2 110
29 1270412 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) BioSystems: REACTOME 1.079E-2 1.367E-2
5.781E-2
4.102E-1
 1 15
30 1270413 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) BioSystems: REACTOME 1.079E-2 1.367E-2
5.781E-2
4.102E-1
 1 15
31 1270411 Mismatch Repair BioSystems: REACTOME 1.151E-2 1.411E-2
5.966E-2
4.374E-1
 1 16
32 M10628 ATM Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.437E-2 1.706E-2
7.215E-2
5.461E-1
 1 20
33 M9703 Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility MSigDB C2 BIOCARTA (v6.0) 1.508E-2 1.737E-2
7.343E-2
5.732E-1
 1 21
34 137959 BARD1 signaling events BioSystems: Pathway Interaction Database 2.078E-2 2.322E-2
9.817E-2
7.895E-1
 1 29
35 1309121 Fanconi Anemia Pathway BioSystems: REACTOME 2.856E-2 3.100E-2
1.311E-1
1.000E0
 1 40
36 83108 Pancreatic cancer BioSystems: KEGG 4.534E-2 4.786E-2
2.023E-1
1.000E0
 1 64
37 137987 Regulation of Telomerase BioSystems: Pathway Interaction Database 4.673E-2 4.799E-2
2.029E-1
1.000E0
 1 66
Show 32 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 1435 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 23509288 Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair. Pubmed 7.106E-15 1.020E-11 8.001E-11 1.020E-11 4 5
2 16595695 A double Holliday junction dissolvasome comprising BLM, topoisomerase IIIalpha, and BLAP75. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
3 18203022 Germline mutations in RAD51, RAD51AP1, RAD51B, RAD51C,RAD51D, RAD52 and RAD54L do not contribute to familial chronic lymphocytic leukemia. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
4 18390547 Functional role of BLAP75 in BLM-topoisomerase IIIalpha-dependent holliday junction processing. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
5 19432957 Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
6 16537486 BLAP75/RMI1 promotes the BLM-dependent dissolution of homologous recombination intermediates. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
7 17728255 Holliday junction processing activity of the BLM-Topo IIIalpha-BLAP75 complex. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
8 20445207 Human topoisomerase IIIalpha is a single-stranded DNA decatenase that is stimulated by BLM and RMI1. Pubmed 9.047E-12 1.623E-9 1.273E-8 1.298E-8 3 3
9 20610542 Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. Pubmed 2.489E-11 3.968E-9 3.113E-8 3.571E-8 4 27
10 15775963 BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity. Pubmed 3.618E-11 4.327E-9 3.395E-8 5.192E-8 3 4
11 19112184 Timeless Maintains Genomic Stability and Suppresses Sister Chromatid Exchange during Unperturbed DNA Replication. Pubmed 3.618E-11 4.327E-9 3.395E-8 5.192E-8 3 4
12 20826342 Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex. Pubmed 3.618E-11 4.327E-9 3.395E-8 5.192E-8 3 4
13 20711169 Rif1 provides a new DNA-binding interface for the Bloom syndrome complex to maintain normal replication. Pubmed 9.045E-11 9.271E-9 7.275E-8 1.298E-7 3 5
14 24108125 Monopolar spindle 1 (MPS1) protein-dependent phosphorylation of RecQ-mediated genome instability protein 2 (RMI2) at serine 112 is essential for BLM-Topo III α-RMI1-RMI2 (BTR) protein complex function upon spindle assembly checkpoint (SAC) activation during mitosis. Pubmed 9.045E-11 9.271E-9 7.275E-8 1.298E-7 3 5
15 18270339 Comprehensive analysis of DNA repair gene variants and risk of meningioma. Pubmed 5.584E-10 5.342E-8 4.191E-7 8.012E-7 4 57
16 20064461 FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia. Pubmed 1.085E-9 9.706E-8 7.616E-7 1.557E-6 3 10
17 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 1.150E-9 9.706E-8 7.616E-7 1.650E-6 4 68
18 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 1.536E-9 1.224E-7 9.608E-7 2.204E-6 4 73
19 12973351 A novel ubiquitin ligase is deficient in Fanconi anemia. Pubmed 1.988E-9 1.502E-7 1.178E-6 2.853E-6 3 12
20 19237606 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Pubmed 2.720E-9 1.951E-7 1.531E-6 3.903E-6 4 84
21 20347429 MHF1-MHF2, a histone-fold-containing protein complex, participates in the Fanconi anemia pathway via FANCM. Pubmed 3.289E-9 2.247E-7 1.763E-6 4.720E-6 3 14
22 22343915 FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway. Pubmed 7.369E-9 4.807E-7 3.772E-6 1.058E-5 3 18
23 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 1.098E-8 6.854E-7 5.378E-6 1.576E-5 5 376
24 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 1.173E-8 6.914E-7 5.425E-6 1.684E-5 5 381
25 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 1.204E-8 6.914E-7 5.425E-6 1.728E-5 5 383
26 21466675 Exploring the link between MORF4L1 and risk of breast cancer. Pubmed 1.827E-8 1.008E-6 7.910E-6 2.621E-5 3 24
27 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 1.954E-8 1.039E-6 8.149E-6 2.804E-5 5 422
28 24239288 TopBP1 controls BLM protein level to maintain genome stability. Pubmed 3.296E-8 1.107E-6 8.684E-6 4.729E-5 3 29
29 30279242 HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA. Pubmed 4.053E-8 1.107E-6 8.684E-6 5.816E-5 3 31
30 20813000 Polymorphisms in DNA repair genes and risk of non-Hodgkin lymphoma in a pooled analysis of three studies. Pubmed 4.053E-8 1.107E-6 8.684E-6 5.816E-5 3 31
31 19064572 Polymorphism in the IL18 gene and epithelial ovarian cancer in non-Hispanic white women. Pubmed 4.691E-8 1.107E-6 8.684E-6 6.732E-5 4 170
32 19714462 Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population. Pubmed 4.919E-8 1.107E-6 8.684E-6 7.058E-5 3 33
33 19956565 SUMO modification regulates BLM and RAD51 interaction at damaged replication forks. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
34 11406610 Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
35 15750625 BLM helicase is activated in BCR/ABL leukemia cells to modulate responses to cisplatin. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
36 17656264 MLH3 and EXO1 alterations in familial colorectal cancer patients not fulfilling Amsterdam criteria. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
37 20531307 BLM has early and late functions in homologous recombination repair in mouse embryonic stem cells. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
38 11309417 Regulation and localization of the Bloom syndrome protein in response to DNA damage. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
39 11809887 Differential effects of Rad52p overexpression on gene targeting and extrachromosomal homologous recombination in a human cell line. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
40 18617519 Rad51 protein stimulates the branch migration activity of Rad54 protein. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
41 10438626 Heteroduplex formation by human Rad51 protein: effects of DNA end-structure, hRP-A and hRad52. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
42 24858046 Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
43 18971343 Human exonuclease 1 and BLM helicase interact to resect DNA and initiate DNA repair. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
44 12433984 The Bloom's syndrome helicase stimulates the activity of human topoisomerase IIIalpha. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
45 21113733 Critical interaction domains between bloom syndrome protein and RAD51. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
46 10734115 The Bloom's syndrome gene product interacts with topoisomerase III. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
47 27362509 Roles of C-Terminal Region of Yeast and Human Rad52 in Rad51-Nucleoprotein Filament Formation and ssDNA Annealing. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
48 12531026 Analysis of mouse Rad54 expression and its implications for homologous recombination. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
49 18974064 Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
50 18054789 Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. Pubmed 4.936E-8 1.107E-6 8.684E-6 7.083E-5 2 2
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 394 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:BLM BLM interactions 3.537E-9 1.393E-6 9.134E-6 1.393E-6 5 140
2 int:WRN WRN interactions 1.038E-8 2.046E-6 1.341E-5 4.091E-6 4 55
3 int:RMI2 RMI2 interactions 2.592E-8 3.404E-6 2.231E-5 1.021E-5 3 13
4 int:RMI1 RMI1 interactions 1.829E-7 1.580E-5 1.035E-4 7.207E-5 3 24
5 int:FANCA FANCA interactions 2.005E-7 1.580E-5 1.035E-4 7.898E-5 4 114
6 int:CENPS CENPS interactions 2.641E-7 1.735E-5 1.137E-4 1.041E-4 3 27
7 int:RAD51 RAD51 interactions 4.985E-7 2.806E-5 1.839E-4 1.964E-4 4 143
8 int:MSH2 MSH2 interactions 6.200E-7 3.053E-5 2.001E-4 2.443E-4 4 151
9 int:RPA3 RPA3 interactions 7.409E-7 3.243E-5 2.126E-4 2.919E-4 5 408
10 int:FANCM FANCM interactions 9.592E-7 3.699E-5 2.425E-4 3.779E-4 3 41
11 int:FAAP100 FAAP100 interactions 1.033E-6 3.699E-5 2.425E-4 4.069E-4 3 42
12 int:RPA1 RPA1 interactions 1.962E-6 6.442E-5 4.223E-4 7.731E-4 5 497
13 int:TOP3A TOP3A interactions 2.765E-6 8.379E-5 5.492E-4 1.089E-3 3 58
14 int:HERC2 HERC2 interactions 8.331E-6 2.308E-4 1.513E-3 3.282E-3 4 290
15 int:WEE1 WEE1 interactions 8.789E-6 2.308E-4 1.513E-3 3.463E-3 3 85
16 int:RAMP1 RAMP1 interactions 1.032E-5 2.391E-4 1.567E-3 4.065E-3 2 10
17 int:RAD54L RAD54L interactions 1.032E-5 2.391E-4 1.567E-3 4.065E-3 2 10
18 int:MSH4 MSH4 interactions 1.261E-5 2.759E-4 1.809E-3 4.967E-3 2 11
19 int:XRCC2 XRCC2 interactions 3.500E-5 7.259E-4 4.758E-3 1.379E-2 2 18
20 int:ELK4 ELK4 interactions 4.345E-5 8.559E-4 5.610E-3 1.712E-2 2 20
21 int:MLH1 MLH1 interactions 5.118E-5 8.852E-4 5.802E-3 2.017E-2 3 153
22 int:CCDC69 CCDC69 interactions 5.279E-5 8.852E-4 5.802E-3 2.080E-2 2 22
23 int:RPA2 RPA2 interactions 5.559E-5 8.852E-4 5.802E-3 2.190E-2 4 470
24 int:CHEK1 CHEK1 interactions 5.633E-5 8.852E-4 5.802E-3 2.219E-2 3 158
25 int:CENPX CENPX interactions 5.781E-5 8.852E-4 5.802E-3 2.278E-2 2 23
26 int:UBE2I UBE2I interactions 5.841E-5 8.852E-4 5.802E-3 2.302E-2 4 476
27 int:SLX1A SLX1A interactions 6.851E-5 9.997E-4 6.553E-3 2.699E-2 2 25
28 int:SUMO1 SUMO1 interactions 8.579E-5 1.207E-3 7.913E-3 3.380E-2 3 182
29 int:ATM ATM interactions 1.085E-4 1.474E-3 9.664E-3 4.275E-2 3 197
30 int:EXO1 EXO1 interactions 1.131E-4 1.485E-3 9.733E-3 4.455E-2 2 32
31 int:ERCC4 ERCC4 interactions 1.516E-4 1.927E-3 1.263E-2
5.973E-2
 2 37
32 int:DNA2 DNA2 interactions 1.686E-4 2.076E-3 1.361E-2
6.643E-2
 2 39
33 int:ERCC2 ERCC2 interactions 1.774E-4 2.118E-3 1.389E-2
6.990E-2
 2 40
34 int:RAD51D RAD51D interactions 1.865E-4 2.161E-3 1.416E-2
7.347E-2
 2 41
35 int:ACTR5 ACTR5 interactions 2.052E-4 2.310E-3 1.514E-2
8.086E-2
 2 43
36 int:RAD52 RAD52 interactions 2.249E-4 2.461E-3 1.613E-2
8.861E-2
 2 45
37 int:FAN1 FAN1 interactions 2.454E-4 2.614E-3 1.713E-2
9.670E-2
 2 47
38 int:MARCKSL1 MARCKSL1 interactions 2.560E-4 2.655E-3 1.740E-2
1.009E-1
 2 48
39 int:TERF2 TERF2 interactions 2.723E-4 2.751E-3 1.804E-2
1.073E-1
 3 269
40 int:PALB2 PALB2 interactions 3.007E-4 2.962E-3 1.941E-2
1.185E-1
 2 52
41 int:RECQL5 RECQL5 interactions 3.364E-4 3.233E-3 2.119E-2
1.326E-1
 2 55
42 int:TUBA1A TUBA1A interactions 3.536E-4 3.317E-3 2.174E-2
1.393E-1
 3 294
43 int:TOPBP1 TOPBP1 interactions 4.700E-4 4.307E-3 2.823E-2
1.852E-1
 2 65
44 int:MIB1 MIB1 interactions 5.450E-4 4.880E-3 3.199E-2
2.147E-1
 2 70
45 int:FANCG FANCG interactions 6.254E-4 5.476E-3 3.589E-2
2.464E-1
 2 75
46 int:ATRX ATRX interactions 6.591E-4 5.645E-3 3.700E-2
2.597E-1
 2 77
47 int:RFC1 RFC1 interactions 7.838E-4 6.570E-3 4.307E-2
3.088E-1
 2 84
48 int:PFN1 PFN1 interactions 9.802E-4 8.010E-3
5.251E-2
3.862E-1
 2 94
49 int:ZNF181 ZNF181 interactions 1.017E-3 8.010E-3
5.251E-2
4.005E-1
 1 2
50 int:RAD51AP2 RAD51AP2 interactions 1.017E-3 8.010E-3
5.251E-2
4.005E-1
 1 2
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12p13-p12.2 12p13-p12.2 5.193E-4 4.672E-3 1.322E-2 4.673E-3 1 2
2 17p12-p11.2 17p12-p11.2 1.038E-3 4.672E-3 1.322E-2 9.344E-3 1 4
3 1q42-q43 1q42-q43 1.816E-3 5.449E-3 1.542E-2 1.635E-2 1 7
4 9q21.32 9q21.32 4.923E-3 1.108E-2 3.134E-2 4.431E-2 1 19
5 1p32 1p32 6.990E-3 1.258E-2 3.559E-2
6.291E-2
 1 27
6 15q15.1 15q15.1 1.317E-2 1.975E-2
5.587E-2
1.185E-1
 1 51
7 15q26.1 15q26.1 1.599E-2 2.055E-2
5.814E-2
1.439E-1
 1 62
8 14q24.3 14q24.3 2.440E-2 2.745E-2
7.766E-2
2.196E-1
 1 95
9 11q13 11q13 3.048E-2 3.048E-2
8.623E-2
2.743E-1
 1 119
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 36 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 5 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1027 MutL homologs genenames.org 1.099E-3 2.884E-3 7.065E-3 6.593E-3 1 4
2 1049 Exonucleases|RecQ like helicases genenames.org 1.373E-3 2.884E-3 7.065E-3 8.241E-3 1 5
3 1050 Topoisomerases genenames.org 1.648E-3 2.884E-3 7.065E-3 9.888E-3 1 6
4 135 Zinc fingers GRF-type genenames.org 1.922E-3 2.884E-3 7.065E-3 1.153E-2 1 7
5 544 Exonucleases genenames.org 4.390E-3 5.268E-3 1.291E-2 2.634E-2 1 16
6 548 Fanconi anemia complementation groups genenames.org 5.485E-3 5.485E-3 1.344E-2 3.291E-2 1 20
Show 1 more annotation

13: Coexpression [Display Chart] 9 input genes in category / 861 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.533E-16 6.486E-13 4.758E-12 6.486E-13 8 230
2 M2075 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the S phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.948E-9 8.388E-7 6.153E-6 1.678E-6 5 162
3 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.437E-9 9.685E-7 7.105E-6 3.820E-6 4 58
4 M2431 DNA repair and replication genes up-regulated in melanoma patients who will relapse vs patients who will not. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.454E-9 9.685E-7 7.105E-6 4.696E-6 4 61
5 M4587 Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 3. MSigDB C7: Immunologic Signatures (v6.0) 5.624E-9 9.685E-7 7.105E-6 4.842E-6 5 200
6 17150101-TableS1h Human Breast Troester06 364genes up DOX-MCF7 GeneSigDB 3.143E-8 4.510E-6 3.309E-5 2.706E-5 5 282
7 M2156 Genes up-regulated in MCF7 cells (breast cancer) at 24 h of estradiol [PubChem=5757] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.284E-8 7.299E-6 5.355E-5 5.410E-5 5 324
8 17150101-TableS1l Human Breast Troester06 436genes-up-DOX-ZR75-1 GeneSigDB 6.782E-8 7.299E-6 5.355E-5 5.839E-5 5 329
9 19043454-TableS2 Human Breast Thorner09 217genes GeneSigDB 3.207E-7 3.068E-5 2.251E-4 2.761E-4 4 167
10 M5048 Genes down-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-acute infection versus splenic primary CD8 effector T cells at day 8 post-chronic infection. MSigDB C7: Immunologic Signatures (v6.0) 6.469E-7 4.735E-5 3.474E-4 5.569E-4 4 199
11 M4173 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the untreated cells at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 6.469E-7 4.735E-5 3.474E-4 5.569E-4 4 199
12 M4604 Genes up-regulated in comparison of CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7 versus CD25- T cells treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v6.0) 6.599E-7 4.735E-5 3.474E-4 5.682E-4 4 200
13 17145885-SuppTable2 Human Lung Kobayashi06 320genes GeneSigDB 1.532E-6 1.004E-4 7.366E-4 1.319E-3 4 247
14 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.633E-6 1.004E-4 7.366E-4 1.406E-3 4 251
15 M1915 Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.416E-6 1.387E-4 1.017E-3 2.080E-3 4 277
16 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.273E-6 1.725E-4 1.265E-3 2.818E-3 4 299
17 20103679-ST3-B Human Breast Wood10 416genes GeneSigDB 3.405E-6 1.725E-4 1.265E-3 2.932E-3 4 302
18 M2606 Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 6 h after exposure to ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.956E-6 1.892E-4 1.388E-3 3.406E-3 3 85
19 17471573-Table2 Human Viral Santegoets07 103genes GeneSigDB 4.393E-6 1.957E-4 1.435E-3 3.782E-3 3 88
20 M1916 Genes down-regulated in neural stem cells (NSC) at both 36 h and 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.545E-6 1.957E-4 1.435E-3 3.913E-3 3 89
21 19139136-TableS2 Human Prostate John-Aryankalayil09 450genes GeneSigDB 5.383E-6 2.207E-4 1.619E-3 4.635E-3 4 339
22 18662380-S3-AURKA Human Breast Wirapati08 355genes AURKA Module GeneSigDB 5.705E-6 2.233E-4 1.638E-3 4.912E-3 4 344
23 M2132 Genes down-regulated in RS4;11 cells (MLL, mixed lineage leukemia) in response to SB216763 [PubChem=176158], an inhibitor of GSK3B [GeneID=2932]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.940E-6 2.972E-4 2.180E-3 6.836E-3 4 374
24 18427120-DataS5 Human Breast Crawford08 187genes GeneSigDB 1.812E-5 6.373E-4 4.675E-3 1.560E-2 3 141
25 M19048 Genes down-regulated in T98G cells (glioblastoma) by TNC [GeneID=3371]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.850E-5 6.373E-4 4.675E-3 1.593E-2 3 142
26 M458 Genes down-regulated in CD4 [GeneID=920] T cells infected with Env/Nef deficient HIV-1 viruses versus those infected with HIV-1 viruses lacking Env, Nef and Vpr. MSigDB C7: Immunologic Signatures (v6.0) 2.011E-5 6.545E-4 4.801E-3 1.731E-2 3 146
27 M2114 Set 'Proliferation Cluster': genes defined in human breast tumor expression data. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.052E-5 6.545E-4 4.801E-3 1.767E-2 3 147
28 M3766 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.224E-5 6.839E-4 5.017E-3 1.915E-2 3 151
29 M2969 Genes down-regulated in T reg: induced versus natural. MSigDB C7: Immunologic Signatures (v6.0) 3.635E-5 8.684E-4 6.370E-3 3.130E-2 3 178
30 M2961 Genes down-regulated in natural T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 3.758E-5 8.684E-4 6.370E-3 3.236E-2 3 180
31 M4288 Genes up-regulated in MCF10A cells (breast cancer) grown at low (mesenchymal phenotype) compared to those grown at high (epithelial, basal-like phenotype) confluency. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.758E-5 8.684E-4 6.370E-3 3.236E-2 3 180
32 M1913 Genes down-regulated in neural stem cells (NSC) at 36 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.078E-5 8.684E-4 6.370E-3 3.511E-2 3 185
33 16478745-SuppTable1 Human Breast Sotiriou06 242genes GeneSigDB 4.626E-5 8.684E-4 6.370E-3 3.983E-2 3 193
34 M5150 Genes up-regulated in comparison of dendritic cells (DC) versus DCs exposed to B. malayi (50 worms/well). MSigDB C7: Immunologic Signatures (v6.0) 4.992E-5 8.684E-4 6.370E-3 4.298E-2 3 198
35 M5041 Genes up-regulated in comparison of splenic primary CD8 effector T cells at day 8 post-acute infection versus splenic secondary CD8 effector T cells at day 8 post-acute infection. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 8.684E-4 6.370E-3 4.363E-2 3 199
36 M3072 Genes down-regulated in comparison of naive vs effector CD8 T cells (4-5 days postinfection). MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 8.684E-4 6.370E-3 4.363E-2 3 199
37 M6507 Genes down-regulated in monocyte-derived dendritic cells: LGALS1 [GeneID=3956] versus vehicle. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 8.684E-4 6.370E-3 4.363E-2 3 199
38 M3250 Genes down-regulated in comparison of IgM-memory B cells versus plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 8.684E-4 6.370E-3 4.363E-2 3 199
39 M8274 Genes down-regulated in B lymphocytes with NFATC1 [GeneID=4772] knockout: control versus stimulated by anti-IgM for 8h. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-5 8.684E-4 6.370E-3 4.363E-2 3 199
40 M4593 Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 7. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
41 M9569 Genes up-regulated in T reg from: peripheral lymph nodes versus thymic precursors. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
42 M8277 Genes up-regulated in B lymphocytes stimulated by anti-IgM for 8h: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
43 M5292 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from young donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
44 M9215 Genes down-regulated in CD8 T cells treated by interferon alpha: STAT1 [GeneID=6772] knockout versus STAT4 [GeneID=6775]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
45 M5746 Genes down-regulated in comparison of lymph node conventional T cells versus thymus conventional T cells. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
46 M9122 Genes down-regulated in CD4 T conv over-expressing: FOXP3 [GeneID=50943] versus IKZF4 and FOXP3 [GeneID=64375;50943]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
47 M5300 Genes down-regulated in comparison of untreated CD4 [GeneID=920] memory T cells from old donors versus those treated with TSST at 40 h. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
48 M9767 Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Th1 versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
49 M4622 Genes up-regulated in comparison of untreated CD25+ T effector cells at day 7 versus untreated CD25- T cells at day 7. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
50 M8507 Genes down-regulated in CD8 T cells: control versus over-expressing ID3 [GeneID=3399]. MSigDB C7: Immunologic Signatures (v6.0) 5.144E-5 8.684E-4 6.370E-3 4.429E-2 3 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 9 input genes in category / 261 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap dev gonad e12.5 M GermCellTestis Oct k1 500 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 6.251E-8 1.632E-5 1.002E-4 1.632E-5 4 105
2 gudmap dev gonad e11.5 M PrimGermCell Oct k2 1000 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.293E-6 1.114E-4 6.843E-4 5.985E-4 4 258
3 GSM791117 500 Stem Cells, SC.CMP.BM, Lineage- Kit+ Sca1- CD34+ FcgRlow, Bone marrow, avg-2 Immgen.org, GSE15907 5.257E-6 1.114E-4 6.843E-4 1.372E-3 4 318
4 gudmap kidney e10.5 UretericTip HoxB7 k4 1000 kidney e10.5 UretericTip HoxB7 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 7.510E-6 1.114E-4 6.843E-4 1.960E-3 4 348
5 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 9.877E-6 1.114E-4 6.843E-4 2.578E-3 4 373
6 gudmap dev gonad e11.5 M PrimGermCell Oct 500 dev gonad e11.5 M PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.019E-5 1.114E-4 6.843E-4 2.661E-3 4 376
7 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.019E-5 1.114E-4 6.843E-4 2.661E-3 4 376
8 gudmap dev gonad e11.5 F PrimGermCell Oct 500 dev gonad e11.5 F PrimGermCell Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.131E-5 1.114E-4 6.843E-4 2.951E-3 4 386
9 gudmap dev gonad e12.5 F GermCellOvary Oct k3 500 dev gonad e12.5 F GermCellOvary Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.139E-5 1.114E-4 6.843E-4 2.973E-3 3 114
10 gudmap dev gonad e12.5 M GermCellTestis Oct 500 dev gonad e12.5 M GermCellTestis Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.142E-5 1.114E-4 6.843E-4 2.981E-3 4 387
11 GSM538352 500 B cells, proB.FrA.BM, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.154E-5 1.114E-4 6.843E-4 3.012E-3 4 388
12 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.263E-5 1.114E-4 6.843E-4 3.297E-3 4 397
13 GSM538345 500 B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.288E-5 1.114E-4 6.843E-4 3.363E-3 4 399
14 GSM399397 500 alpha beta T cells, T.DPbl.Th, 4+ 8+ TCR-/lo FSChi, Thymus, avg-3 Immgen.org, GSE15907 1.288E-5 1.114E-4 6.843E-4 3.363E-3 4 399
15 GSM538358 500 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.301E-5 1.114E-4 6.843E-4 3.396E-3 4 400
16 GSM791108 500 Stem Cells, SC.MEP.BM, Lineage- Kit+ Sca1- CD34- FcgR-/low, Bone marrow, avg-2 Immgen.org, GSE15907 1.314E-5 1.114E-4 6.843E-4 3.430E-3 4 401
17 GSM791105 500 Stem Cells, SC.MDP.BM, Sca1- Flt3+ MCSFR+ cKithi, Bone marrow, avg-3 Immgen.org, GSE15907 1.327E-5 1.114E-4 6.843E-4 3.464E-3 4 402
18 GSM399450 500 B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2 Immgen.org, GSE15907 1.327E-5 1.114E-4 6.843E-4 3.464E-3 4 402
19 GSM791129 500 B cells, MLP.BM, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Bone marrow, avg-2 Immgen.org, GSE15907 1.353E-5 1.114E-4 6.843E-4 3.532E-3 4 404
20 GSM538343 500 B cells, proB.CLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R+, Bone marrow, avg-1 Immgen.org, GSE15907 1.366E-5 1.114E-4 6.843E-4 3.567E-3 4 405
21 gudmap dev gonad e12.5 F GermCellOvary Oct 500 dev gonad e12.5 F GermCellOvary Oct top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 1.380E-5 1.114E-4 6.843E-4 3.601E-3 4 406
22 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 1.420E-5 1.114E-4 6.843E-4 3.707E-3 4 409
23 gudmap dev gonad e11.5 M GonadVasMes Flk k3 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.431E-5 1.114E-4 6.843E-4 3.734E-3 3 123
24 GSM791122 500 Fetal Liver, SC.STSL.FL, IgM- CD24- CD117+ IL7R- CD150- CD48- AA4.1+ CD43+, Fetal Liver, avg-2 Immgen.org, GSE15907 1.434E-5 1.114E-4 6.843E-4 3.743E-3 4 410
25 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.434E-5 1.114E-4 6.843E-4 3.743E-3 4 410
26 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 1.476E-5 1.114E-4 6.843E-4 3.852E-3 4 413
27 GSM476660 500 gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.490E-5 1.114E-4 6.843E-4 3.889E-3 4 414
28 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 1.533E-5 1.114E-4 6.843E-4 4.001E-3 4 417
29 GSM538350 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.548E-5 1.114E-4 6.843E-4 4.039E-3 4 418
30 GSM538348 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.562E-5 1.114E-4 6.843E-4 4.077E-3 4 419
31 GSM476664 500 gamma delta T cells, Tgd.vg3+24alo.e17.Th, TCRd+ Vg3+ CD24-, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.562E-5 1.114E-4 6.843E-4 4.077E-3 4 419
32 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 1.577E-5 1.114E-4 6.843E-4 4.116E-3 4 420
33 GSM791136 500 alpha beta T cells, preT.DN2.Th, Lin-/lo CD25hi CD44+ cKit+, Thymus, avg-3 Immgen.org, GSE15907 1.577E-5 1.114E-4 6.843E-4 4.116E-3 4 420
34 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 1.607E-5 1.114E-4 6.843E-4 4.193E-3 4 422
35 GSM538355 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 1.607E-5 1.114E-4 6.843E-4 4.193E-3 4 422
36 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 1.607E-5 1.114E-4 6.843E-4 4.193E-3 4 422
37 GSM791124 500 B cells, MLP.BM, CD19- IgM- CD43+ CD24- AA4.1+ CD45R- CD117+ IL7R-, Bone marrow, avg-2 Immgen.org, GSE15907 1.607E-5 1.114E-4 6.843E-4 4.193E-3 4 422
38 GSM791126 500 Fetal Liver, SC.LTSL.FL, IgM- CD24- CD117+ IL7R- CD150+ CD48- AA4.1+ CD43+, Fetal Liver, avg-3 Immgen.org, GSE15907 1.622E-5 1.114E-4 6.843E-4 4.233E-3 4 423
39 gudmap dev gonad e11.5 F PrimGermCell Oct k3 1000 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.313E-5 1.548E-4 9.511E-4 6.038E-3 4 463
40 gudmap dev gonad e12.5 M GermCellTestis Oct k2 1000 dev gonad e12.5 M GermCellTestis Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.423E-4 9.288E-4 5.706E-3 3.715E-2 3 266
41 gudmap kidney P3 CapMes Crym k4 1000 kidney P3 CapMes Crym k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.388E-4 1.456E-3 8.948E-3
6.233E-2
 3 317
42 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 2.455E-4 1.456E-3 8.948E-3
6.408E-2
 3 320
43 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes 2.455E-4 1.456E-3 8.948E-3
6.408E-2
 3 320
44 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap 2.455E-4 1.456E-3 8.948E-3
6.408E-2
 3 320
45 gudmap dev gonad e13.5 M GermCell Oct k1 1000 dev gonad e13.5 M GermCell Oct k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 2.785E-4 1.615E-3 9.924E-3
7.269E-2
 3 334
46 GSM538347 500 B cells, proB.CLP.BM, AA4.1+ CD117+ IL7R+ CD45R- CD24- CD19- IgM-, Bone marrow, avg-1 Immgen.org, GSE15907 2.884E-4 1.636E-3 1.005E-2
7.527E-2
 3 338
47 gudmap dev gonad e11.5 M PrimGermCell Oct k1 500 dev gonad e11.5 M PrimGermCell Oct k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.394E-4 1.864E-3 1.145E-2
8.858E-2
 2 68
48 GSM605773 500 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 3.442E-4 1.864E-3 1.145E-2
8.985E-2
 3 359
49 gudmap dev gonad e13.5 F MeioticGermCell Oct k2 1000 dev gonad e13.5 F MeioticGermCell Oct k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 3.499E-4 1.864E-3 1.145E-2
9.133E-2
 3 361
50 gudmap dev gonad e11.5 F PrimGermCell Oct k3 500 dev gonad e11.5 F PrimGermCell Oct k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 3.805E-4 1.986E-3 1.220E-2
9.931E-2
 2 72
Show 45 more annotations

15: Computational [Display Chart] 5 input genes in category / 33 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.192E-5 1.232E-3 5.037E-3 2.043E-3 3 187
2 M16797 MODULE 318 Genes in the cancer module 318. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.466E-5 1.232E-3 5.037E-3 2.464E-3 2 28
3 M5468 MODULE 54 Cell cycle (expression cluster). MSigDb: C4 - CM: Cancer Modules (v6.0) 1.691E-4 1.861E-3 7.608E-3 5.582E-3 3 262
4 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.604E-4 2.148E-3 8.784E-3 8.593E-3 3 303
5 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.617E-4 3.707E-3 1.516E-2 1.854E-2 3 393
6 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.297E-3 2.913E-2
1.191E-1
1.748E-1
 2 237
7 M14316 MODULE 392 rRNA processing and DNA repair. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.936E-3 4.213E-2
1.723E-1
2.949E-1
 1 18
Show 2 more annotations

16: MicroRNA [Display Chart] 9 input genes in category / 208 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4321:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.121E-3 4.817E-2
2.850E-1
2.331E-1
 1 9
2 hsa-miR-4296:mirSVR highEffct hsa-miR-4296:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.313E-3 4.817E-2
2.850E-1
2.731E-1
 2 443
3 hsa-miR-4265:mirSVR highEffct hsa-miR-4265:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.342E-3 4.817E-2
2.850E-1
2.792E-1
 2 448
4 hsa-miR-4722-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.432E-3 4.817E-2
2.850E-1
2.979E-1
 2 463
5 hsa-miR-6727-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.444E-3 4.817E-2
2.850E-1
3.005E-1
 2 465
6 hsa-miR-4322:mirSVR highEffct hsa-miR-4322:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.475E-3 4.817E-2
2.850E-1
3.069E-1
 2 470
7 hsa-miR-4279:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.621E-3 4.817E-2
2.850E-1
3.372E-1
 2 493
8 hsa-miR-1301-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.476E-3 4.942E-2
2.924E-1
9.311E-1
 1 36
9 hsa-miR-6502-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.476E-3 4.942E-2
2.924E-1
9.311E-1
 1 36
10 hsa-miR-624-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.724E-3 4.942E-2
2.924E-1
9.827E-1
 1 38
11 hsa-miR-7975:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.973E-3 4.942E-2
2.924E-1
1.000E0
 1 40
12 hsa-miR-6767-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.593E-3 4.942E-2
2.924E-1
1.000E0
 1 45
13 hsa-miR-5571-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.212E-3 4.942E-2
2.924E-1
1.000E0
 1 50
14 hsa-miR-4454:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.203E-3 4.942E-2
2.924E-1
1.000E0
 1 58
15 hsa-miR-4529-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.574E-3 4.942E-2
2.924E-1
1.000E0
 1 61
16 hsa-miR-3127-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.946E-3 4.942E-2
2.924E-1
1.000E0
 1 64
17 hsa-miR-4712-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.193E-3 4.942E-2
2.924E-1
1.000E0
 1 66
18 hsa-miR-6813-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.440E-3 4.942E-2
2.924E-1
1.000E0
 1 68
19 hsa-miR-921:Functional MTI Functional MTI miRTarbase 8.440E-3 4.942E-2
2.924E-1
1.000E0
 1 68
20 hsa-miR-219a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.564E-3 4.942E-2
2.924E-1
1.000E0
 1 69
21 hsa-miR-4645-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.811E-3 4.942E-2
2.924E-1
1.000E0
 1 71
22 hsa-miR-122-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.182E-3 4.942E-2
2.924E-1
1.000E0
 1 74
23 hsa-miR-571:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.306E-3 4.942E-2
2.924E-1
1.000E0
 1 75
24 hsa-miR-874-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.429E-3 4.942E-2
2.924E-1
1.000E0
 1 76
25 hsa-miR-3141:mirSVR highEffct hsa-miR-3141:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.923E-3 4.942E-2
2.924E-1
1.000E0
 1 80
26 hsa-miR-151a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 9.923E-3 4.942E-2
2.924E-1
1.000E0
 1 80
27 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.029E-2 4.942E-2
2.924E-1
1.000E0
 1 83
28 hsa-miR-770-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.066E-2 4.942E-2
2.924E-1
1.000E0
 1 86
29 hsa-miR-493-3p:Functional MTI Functional MTI miRTarbase 1.091E-2 4.942E-2
2.924E-1
1.000E0
 1 88
30 hsa-miR-7855-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 4.942E-2
2.924E-1
1.000E0
 1 90
31 hsa-miR-92a-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.942E-2
2.924E-1
1.000E0
 1 91
32 hsa-miR-4742-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.942E-2
2.924E-1
1.000E0
 1 91
33 hsa-miR-1271-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.942E-2
2.924E-1
1.000E0
 1 91
34 hsa-miR-550a-3-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.942E-2
2.924E-1
1.000E0
 1 91
35 hsa-miR-3934-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.153E-2 4.942E-2
2.924E-1
1.000E0
 1 93
36 hsa-miR-675:mirSVR highEffct hsa-miR-675:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.153E-2 4.942E-2
2.924E-1
1.000E0
 1 93
37 hsa-miR-6073:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.177E-2 4.942E-2
2.924E-1
1.000E0
 1 95
38 hsa-miR-550a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.177E-2 4.942E-2
2.924E-1
1.000E0
 1 95
39 ATAGGAA,MIR-202:MSigDB ATAGGAA,MIR-202:MSigDB MSigDB 1.227E-2 4.942E-2
2.924E-1
1.000E0
 1 99
40 hsa-miR-4792:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.251E-2 4.942E-2
2.924E-1
1.000E0
 1 101
41 hsa-miR-384:Non-Functional MTI Non-Functional MTI miRTarbase 1.251E-2 4.942E-2
2.924E-1
1.000E0
 1 101
42 hsa-miR-1306:mirSVR highEffct hsa-miR-1306:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.251E-2 4.942E-2
2.924E-1
1.000E0
 1 101
43 hsa-miR-3685:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.264E-2 4.942E-2
2.924E-1
1.000E0
 1 102
44 hsa-miR-3174:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.325E-2 4.942E-2
2.924E-1
1.000E0
 1 107
45 hsa-miR-564:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.374E-2 4.942E-2
2.924E-1
1.000E0
 1 111
46 hsa-miR-6823-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.374E-2 4.942E-2
2.924E-1
1.000E0
 1 111
47 hsa-miR-514b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.411E-2 4.942E-2
2.924E-1
1.000E0
 1 114
48 hsa-miR-513c-5p:Functional MTI Functional MTI miRTarbase 1.411E-2 4.942E-2
2.924E-1
1.000E0
 1 114
49 hsa-miR-6877-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.448E-2 4.942E-2
2.924E-1
1.000E0
 1 117
50 hsa-miR-589:PITA hsa-miR-589:PITA TOP PITA 1.461E-2 4.942E-2
2.924E-1
1.000E0
 1 118
Show 45 more annotations

17: Drug [Display Chart] 9 input genes in category / 3311 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011840938 2hzy Stitch 5.108E-17 1.691E-13 1.468E-12 1.691E-13 5 7
2 CID000004156 methyl methanesulfonate Stitch 3.421E-14 5.664E-11 4.917E-10 1.133E-10 8 364
3 CID000002538 NSC302991 Stitch 6.959E-12 7.680E-9 6.668E-8 2.304E-8 7 353
4 CID000005192 sebacate Stitch 1.877E-11 1.553E-8 1.349E-7 6.214E-8 6 181
5 ctd:C547185 riccardin D CTD 4.449E-11 2.946E-8 2.558E-7 1.473E-7 5 76
6 CID000003657 hydroxyurea Stitch 3.845E-9 1.865E-6 1.620E-5 1.273E-5 6 438
7 ctd:C408982 CPG-oligonucleotide CTD 3.944E-9 1.865E-6 1.620E-5 1.306E-5 5 184
8 CID000005746 mitomycin C Stitch 1.527E-8 6.321E-6 5.488E-5 5.057E-5 5 241
9 CID000011254 diepoxybutane Stitch 7.020E-8 2.583E-5 2.242E-4 2.324E-4 4 113
10 CID000004114 8-MOP Stitch 8.359E-8 2.768E-5 2.403E-4 2.768E-4 4 118
11 CID000061437 trichloramine Stitch 4.476E-7 1.347E-4 1.170E-3 1.482E-3 3 41
12 CID006476706 Isonicotinoyl, rifamycin Stitch 1.039E-6 2.866E-4 2.488E-3 3.439E-3 3 54
13 CID000175468 12-bromolaurate Stitch 1.225E-6 3.119E-4 2.708E-3 4.055E-3 3 57
14 CID000131350 saintopin Stitch 2.069E-6 4.829E-4 4.193E-3 6.849E-3 2 6
15 CID011984575 2 rF2 Stitch 2.188E-6 4.829E-4 4.193E-3 7.243E-3 3 69
16 CID000107747 o-AMSA Stitch 4.961E-6 1.027E-3 8.914E-3 1.643E-2 2 9
17 CID006433481 hygromycin A Stitch 6.914E-6 1.347E-3 1.169E-2 2.289E-2 3 101
18 ctd:C059765 amphotericin B, deoxycholate drug combination CTD 9.855E-6 1.813E-3 1.574E-2 3.263E-2 4 390
19 CID000005955 4NQO Stitch 1.049E-5 1.827E-3 1.586E-2 3.472E-2 3 116
20 CID000006235 Trenimon Stitch 2.352E-5 3.893E-3 3.380E-2
7.787E-2
 2 19
21 CID005289542 UV-C Stitch 2.904E-5 4.537E-3 3.939E-2
9.615E-2
 3 163
22 CID000068463 1,6-naphthalenediol Stitch 3.175E-5 4.537E-3 3.939E-2
1.051E-1
 2 22
23 ctd:C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline CTD 3.235E-5 4.537E-3 3.939E-2
1.071E-1
 3 169
24 2499 DN Quercetine dihydrate [6151-25-3]; Down 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 4.659E-5 4.537E-3 3.939E-2
1.543E-1
 3 191
25 6160 DN Oxyphenbutazone [129-20-4]; Down 200; 12.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 4.881E-5 4.537E-3 3.939E-2
1.616E-1
 3 194
26 919 UP carbamazepine; Up 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 4.956E-5 4.537E-3 3.939E-2
1.641E-1
 3 195
27 2454 DN Glycocholic acid [475-31-0]; Down 200; 8.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 4.956E-5 4.537E-3 3.939E-2
1.641E-1
 3 195
28 2315 DN Metoclopramide monohydrochloride [7232-21-5]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.032E-5 4.537E-3 3.939E-2
1.666E-1
 3 196
29 5274 DN Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.109E-5 4.537E-3 3.939E-2
1.691E-1
 3 197
30 3532 DN Loracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.109E-5 4.537E-3 3.939E-2
1.691E-1
 3 197
31 6819 DN Cephalothin sodium salt [58-71-9]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.109E-5 4.537E-3 3.939E-2
1.691E-1
 3 197
32 7320 UP Harmol hydrochloride monohydrate [40580-83-4]; Up 200; 15.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.186E-5 4.537E-3 3.939E-2
1.717E-1
 3 198
33 4435 DN retinoic acid; Down 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.186E-5 4.537E-3 3.939E-2
1.717E-1
 3 198
34 7501 DN Suramin sodium salt; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 5.186E-5 4.537E-3 3.939E-2
1.717E-1
 3 198
35 ctd:C012976 flumequine CTD 5.189E-5 4.537E-3 3.939E-2
1.718E-1
 2 28
36 6325 UP Molsidomine [25717-80-0]; Up 200; 16.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.265E-5 4.537E-3 3.939E-2
1.743E-1
 3 199
37 2960 DN Phensuximide [86-34-0]; Down 200; 21.2uM; HL60; HT HG-U133A Broad Institute CMAP Down 5.265E-5 4.537E-3 3.939E-2
1.743E-1
 3 199
38 4533 UP Homosalate [118-56-9]; Up 200; 15.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 5.344E-5 4.537E-3 3.939E-2
1.769E-1
 3 200
39 4843 DN Zuclopenthixol hydrochloride [633-59-0]; Down 200; 9.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 5.344E-5 4.537E-3 3.939E-2
1.769E-1
 3 200
40 CID000072511 Phleomycin Stitch 5.969E-5 4.941E-3 4.290E-2
1.976E-1
 2 30
41 ctd:D008154 Lucanthone CTD 6.355E-5 5.132E-3 4.456E-2
2.104E-1
 3 212
42 ctd:C010914 2,4-diaminotoluene CTD 1.049E-4 8.038E-3
6.979E-2
3.473E-1
 3 251
43 CID000073670 clofentezine Stitch 1.068E-4 8.038E-3
6.979E-2
3.537E-1
 2 40
44 ctd:C477361 LAQ824 CTD 1.068E-4 8.038E-3
6.979E-2
3.537E-1
 2 40
45 ctd:C030090 phosphoramide mustard CTD 1.236E-4 9.093E-3
7.895E-2
4.092E-1
 2 43
46 ctd:C005246 myristicin CTD 1.354E-4 9.342E-3
8.111E-2
4.484E-1
 2 45
47 CID000002179 amsacrine Stitch 1.354E-4 9.342E-3
8.111E-2
4.484E-1
 2 45
48 CID000005802 5-bromouracil Stitch 1.354E-4 9.342E-3
8.111E-2
4.484E-1
 2 45
49 CID000004638 AC1L1IM7 Stitch 1.416E-4 9.566E-3
8.305E-2
4.687E-1
 2 46
50 CID000115150 ICRF-193 Stitch 1.954E-4 1.294E-2
1.123E-1
6.470E-1
 2 54
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 228 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1333600 Hereditary Malignant Neoplasm DisGeNET BeFree 4.407E-6 5.989E-4 3.599E-3 1.005E-3 3 62
2 C3469521 FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder) DisGeNET Curated 6.767E-6 5.989E-4 3.599E-3 1.543E-3 4 252
3 C0015625 Fanconi Anemia DisGeNET Curated 1.101E-5 5.989E-4 3.599E-3 2.510E-3 4 285
4 C0005859 Bloom Syndrome DisGeNET Curated 1.185E-5 5.989E-4 3.599E-3 2.701E-3 3 86
5 C0231341 Premature aging syndrome DisGeNET Curated 1.313E-5 5.989E-4 3.599E-3 2.995E-3 3 89
6 C1333990 Hereditary Nonpolyposis Colorectal Cancer DisGeNET Curated 2.985E-5 1.134E-3 6.816E-3 6.806E-3 3 117
7 C0346153 Breast Cancer, Familial DisGeNET Curated 5.551E-5 1.808E-3 1.086E-2 1.266E-2 3 144
8 cv:C0346153 Familial cancer of breast Clinical Variations 7.520E-5 1.905E-3 1.145E-2 1.715E-2 2 24
9 OMIN:114480 BREAST CANCER OMIM 7.520E-5 1.905E-3 1.145E-2 1.715E-2 2 24
10 C1859424 Increased chromosomal breakage DisGeNET Curated 9.555E-5 2.179E-3 1.309E-2 2.179E-2 2 27
11 C0376628 Chromosome Breakage DisGeNET Curated 1.348E-4 2.795E-3 1.679E-2 3.074E-2 2 32
12 cv:C0005859 Bloom syndrome Clinical Variations 5.554E-4 7.914E-3 4.755E-2
1.266E-1
 1 1
13 cv:C3281089 Mirror movements 2 Clinical Variations 5.554E-4 7.914E-3 4.755E-2
1.266E-1
 1 1
14 C1858380 COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 7 (disorder) DisGeNET Curated 5.554E-4 7.914E-3 4.755E-2
1.266E-1
 1 1
15 OMIN:210900 BLOOM SYNDROME; BLM OMIM 5.554E-4 7.914E-3 4.755E-2
1.266E-1
 1 1
16 cv:C1858380 Hereditary nonpolyposis colorectal cancer type 7 Clinical Variations 5.554E-4 7.914E-3 4.755E-2
1.266E-1
 1 1
17 C0017185 Gastrointestinal Neoplasms DisGeNET Curated 8.684E-4 1.165E-2
6.998E-2
1.980E-1
 2 81
18 C0016382 Flushing DisGeNET Curated 9.782E-4 1.239E-2
7.445E-2
2.230E-1
 2 86
19 C1832586 DERMATITIS HERPETIFORMIS, FAMILIAL DisGeNET BeFree 1.110E-3 1.266E-2
7.607E-2
2.532E-1
 1 2
20 C4021632 Facial telangiectasia in butterfly midface distribution DisGeNET Curated 1.110E-3 1.266E-2
7.607E-2
2.532E-1
 1 2
21 C0043119 Werner Syndrome DisGeNET Curated 1.217E-3 1.321E-2
7.939E-2
2.775E-1
 2 96
22 C3806179 Spotty hyperpigmentation DisGeNET Curated 1.665E-3 1.460E-2
8.775E-2
3.797E-1
 1 3
23 C1563697 Chromosome Instability Syndromes DisGeNET BeFree 1.665E-3 1.460E-2
8.775E-2
3.797E-1
 1 3
24 C4083046 Absent upper lateral incisors DisGeNET Curated 1.665E-3 1.460E-2
8.775E-2
3.797E-1
 1 3
25 C4275075 Atypical Werner syndrome DisGeNET Curated 1.665E-3 1.460E-2
8.775E-2
3.797E-1
 1 3
26 C1849950 Agenesis of maxillary lateral incisor DisGeNET Curated 1.665E-3 1.460E-2
8.775E-2
3.797E-1
 1 3
27 C0008626 Congenital chromosomal disease DisGeNET Curated 2.122E-3 1.633E-2
9.810E-2
4.839E-1
 3 499
28 C0743101 developmentally delayed DisGeNET BeFree 2.220E-3 1.633E-2
9.810E-2
5.061E-1
 1 4
29 cv:C0024305 Malignant lymphoma, non-Hodgkin Clinical Variations 2.220E-3 1.633E-2
9.810E-2
5.061E-1
 1 4
30 C3806178 Spotty hypopigmentation DisGeNET Curated 2.220E-3 1.633E-2
9.810E-2
5.061E-1
 1 4
31 cv:C0476089 Endometrial carcinoma Clinical Variations 2.220E-3 1.633E-2
9.810E-2
5.061E-1
 1 4
32 C0751688 Malignant Squamous Cell Neoplasm DisGeNET Curated 2.492E-3 1.709E-2
1.027E-1
5.683E-1
 2 138
33 C0004509 Azoospermia DisGeNET Curated 2.528E-3 1.709E-2
1.027E-1
5.764E-1
 2 139
34 C0025284 Meningeal Neoplasms DisGeNET BeFree 2.774E-3 1.709E-2
1.027E-1
6.325E-1
 1 5
35 OMIN:608089 ENDOMETRIAL CANCER OMIM 2.774E-3 1.709E-2
1.027E-1
6.325E-1
 1 5
36 OMIN:605027 LYMPHOMA, NON-HODGKIN, FAMILIAL OMIM 2.774E-3 1.709E-2
1.027E-1
6.325E-1
 1 5
37 C0024145 Chilblain lupus 1 DisGeNET Curated 2.774E-3 1.709E-2
1.027E-1
6.325E-1
 1 5
38 C0346429 Multiple malignancy DisGeNET BeFree 3.927E-3 2.356E-2
1.416E-1
8.954E-1
 2 174
39 C2675520 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 2 DisGeNET Curated 4.435E-3 2.528E-2
1.519E-1
1.000E0
 1 8
40 C0009405 Hereditary Nonpolyposis Colorectal Neoplasms DisGeNET Curated 4.435E-3 2.528E-2
1.519E-1
1.000E0
 1 8
41 C3150659 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 3 DisGeNET Curated 4.989E-3 2.774E-2
1.667E-1
1.000E0
 1 9
42 C0454455 Mirror movements disorder DisGeNET Curated 5.542E-3 2.938E-2
1.766E-1
1.000E0
 1 10
43 C0342510 Ovarian dysgenesis DisGeNET BeFree 5.542E-3 2.938E-2
1.766E-1
1.000E0
 1 10
44 C0239989 Decreased IgM DisGeNET Curated 6.094E-3 3.088E-2
1.855E-1
1.000E0
 1 11
45 C0158733 Hand polydactyly DisGeNET Curated 6.094E-3 3.088E-2
1.855E-1
1.000E0
 1 11
46 C0598935 Tumor Initiation DisGeNET BeFree 7.049E-3 3.350E-2
2.013E-1
1.000E0
 2 235
47 C3809768 IMMUNODEFICIENCY 13 DisGeNET Curated 7.199E-3 3.350E-2
2.013E-1
1.000E0
 1 13
48 C2676676 BREAST-OVARIAN CANCER, FAMILIAL, SUSCEPTIBILITY TO, 1 DisGeNET Curated 7.199E-3 3.350E-2
2.013E-1
1.000E0
 1 13
49 C3160738 FANCONI ANEMIA, COMPLEMENTATION GROUP D2 DisGeNET Curated 7.199E-3 3.350E-2
2.013E-1
1.000E0
 1 13
50 C0271160 Cortical cataract DisGeNET Curated 8.302E-3 3.786E-2
2.275E-1
1.000E0
 1 15
Show 45 more annotations