Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc115_32, positive side

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1: GO: Molecular Function [Display Chart] 32 input genes in category / 179 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0050700 CARD domain binding 5.962E-13 9.862E-11 5.688E-10 1.067E-10 5 8
2 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 1.102E-12 9.862E-11 5.688E-10 1.972E-10 7 46
3 GO:0061134 peptidase regulator activity 8.975E-11 5.355E-9 3.089E-8 1.607E-8 9 222
4 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process 1.627E-10 7.280E-9 4.199E-8 2.912E-8 5 20
5 GO:0016505 peptidase activator activity involved in apoptotic process 3.518E-10 1.259E-8 7.264E-8 6.297E-8 5 23
6 GO:0008384 IkappaB kinase activity 4.580E-9 1.366E-7 7.881E-7 8.199E-7 3 3
7 GO:0016504 peptidase activator activity 9.824E-9 2.512E-7 1.449E-6 1.758E-6 5 43
8 GO:0042834 peptidoglycan binding 9.972E-7 2.231E-5 1.287E-4 1.785E-4 3 12
9 GO:0002020 protease binding 1.436E-6 2.856E-5 1.647E-4 2.570E-4 5 115
10 GO:0097153 cysteine-type endopeptidase activity involved in apoptotic process 2.055E-6 3.679E-5 2.122E-4 3.679E-4 3 15
11 GO:0004869 cysteine-type endopeptidase inhibitor activity 2.831E-6 4.606E-5 2.657E-4 5.067E-4 4 58
12 GO:0004197 cysteine-type endopeptidase activity 1.370E-5 2.044E-4 1.179E-3 2.452E-3 4 86
13 GO:0097110 scaffold protein binding 1.131E-4 1.557E-3 8.982E-3 2.024E-2 3 55
14 GO:0004866 endopeptidase inhibitor activity 2.003E-4 2.539E-3 1.465E-2 3.586E-2 4 171
15 GO:0003725 double-stranded RNA binding 2.128E-4 2.539E-3 1.465E-2 3.809E-2 3 68
16 GO:0061135 endopeptidase regulator activity 2.286E-4 2.558E-3 1.475E-2 4.092E-2 4 177
17 GO:0030414 peptidase inhibitor activity 2.438E-4 2.567E-3 1.480E-2 4.363E-2 4 180
18 GO:0003727 single-stranded RNA binding 3.569E-4 3.494E-3 2.015E-2
6.388E-2
 3 81
19 GO:0008234 cysteine-type peptidase activity 3.709E-4 3.494E-3 2.015E-2
6.639E-2
 4 201
20 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 8.338E-4 7.463E-3 4.304E-2
1.493E-1
 2 25
21 GO:0070260 5'-tyrosyl-DNA phosphodiesterase activity 1.715E-3 1.279E-2
7.376E-2
3.070E-1
 1 1
22 GO:0036317 tyrosyl-RNA phosphodiesterase activity 1.715E-3 1.279E-2
7.376E-2
3.070E-1
 1 1
23 GO:0017024 myosin I binding 1.715E-3 1.279E-2
7.376E-2
3.070E-1
 1 1
24 GO:0032500 muramyl dipeptide binding 1.715E-3 1.279E-2
7.376E-2
3.070E-1
 1 1
25 GO:0004386 helicase activity 3.136E-3 2.245E-2
1.295E-1
5.613E-1
 3 172
26 GO:0070259 tyrosyl-DNA phosphodiesterase activity 3.427E-3 2.272E-2
1.310E-1
6.134E-1
 1 2
27 GO:0032090 Pyrin domain binding 3.427E-3 2.272E-2
1.310E-1
6.134E-1
 1 2
28 GO:0043621 protein self-association 4.141E-3 2.647E-2
1.527E-1
7.412E-1
 2 56
29 GO:0004857 enzyme inhibitor activity 4.370E-3 2.697E-2
1.556E-1
7.823E-1
 4 393
30 GO:0004842 ubiquitin-protein transferase activity 5.252E-3 3.134E-2
1.807E-1
9.402E-1
 4 414
31 GO:0005539 glycosaminoglycan binding 6.154E-3 3.553E-2
2.049E-1
1.000E0
 3 219
32 GO:0019787 ubiquitin-like protein transferase activity 6.554E-3 3.602E-2
2.078E-1
1.000E0
 4 441
33 GO:0089720 caspase binding 6.842E-3 3.602E-2
2.078E-1
1.000E0
 1 4
34 GO:0035877 death effector domain binding 6.842E-3 3.602E-2
2.078E-1
1.000E0
 1 4
35 GO:0004674 protein serine/threonine kinase activity 7.140E-3 3.652E-2
2.106E-1
1.000E0
 4 452
36 GO:0004175 endopeptidase activity 7.418E-3 3.688E-2
2.127E-1
1.000E0
 4 457
37 GO:0019209 kinase activator activity 9.519E-3 4.168E-2
2.404E-1
1.000E0
 2 86
38 GO:0052714 mannosyl-inositol phosphorylceramide phospholipase activity 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
39 GO:0036435 K48-linked polyubiquitin modification-dependent protein binding 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
40 GO:0052715 mannosyl-diinositol phosphorylceramide phospholipase activity 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
41 GO:0004120 photoreceptor cyclic-nucleotide phosphodiesterase activity 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
42 GO:0044688 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
43 GO:0052712 inositol phosphosphingolipid phospholipase activity 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
44 GO:0052713 inositol phosphorylceramide phospholipase activity 1.025E-2 4.168E-2
2.404E-1
1.000E0
 1 6
45 GO:0005000 vasopressin receptor activity 1.194E-2 4.648E-2
2.681E-1
1.000E0
 1 7
46 GO:0005138 interleukin-6 receptor binding 1.194E-2 4.648E-2
2.681E-1
1.000E0
 1 7
Show 41 more annotations

2: GO: Biological Process [Display Chart] 31 input genes in category / 1139 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0002218 activation of innate immune response 2.621E-28 2.985E-25 2.273E-24 2.985E-25 19 256
2 GO:0045089 positive regulation of innate immune response 7.927E-27 4.514E-24 3.438E-23 9.028E-24 19 305
3 GO:0045088 regulation of innate immune response 4.288E-25 1.628E-22 1.240E-21 4.884E-22 19 375
4 GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling 1.023E-24 2.912E-22 2.218E-21 1.165E-21 17 241
5 GO:0031349 positive regulation of defense response 5.183E-24 1.181E-21 8.991E-21 5.903E-21 19 427
6 GO:0007249 I-kappaB kinase/NF-kappaB signaling 7.851E-24 1.490E-21 1.135E-20 8.942E-21 17 271
7 GO:0002758 innate immune response-activating signal transduction 1.512E-22 2.460E-20 1.874E-19 1.722E-19 16 248
8 GO:0001819 positive regulation of cytokine production 2.295E-22 3.268E-20 2.489E-19 2.614E-19 18 418
9 GO:0051092 positive regulation of NF-kappaB transcription factor activity 2.547E-20 3.223E-18 2.455E-17 2.901E-17 13 140
10 GO:0002221 pattern recognition receptor signaling pathway 2.125E-19 2.421E-17 1.843E-16 2.421E-16 13 164
11 GO:0051091 positive regulation of DNA-binding transcription factor activity 7.815E-19 8.092E-17 6.163E-16 8.902E-16 14 247
12 GO:0002757 immune response-activating signal transduction 4.035E-18 3.830E-16 2.917E-15 4.596E-15 16 467
13 GO:2000116 regulation of cysteine-type endopeptidase activity 2.351E-17 2.060E-15 1.569E-14 2.678E-14 13 234
14 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling 5.907E-17 4.806E-15 3.660E-14 6.728E-14 12 181
15 GO:0002753 cytoplasmic pattern recognition receptor signaling pathway 1.647E-16 1.251E-14 9.525E-14 1.876E-13 9 55
16 GO:0051090 regulation of DNA-binding transcription factor activity 5.672E-16 4.038E-14 3.075E-13 6.460E-13 14 395
17 GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process 6.687E-16 4.481E-14 3.412E-13 7.617E-13 12 221
18 GO:2001056 positive regulation of cysteine-type endopeptidase activity 1.393E-14 8.817E-13 6.715E-12 1.587E-11 10 138
19 GO:0052548 regulation of endopeptidase activity 1.977E-14 1.185E-12 9.025E-12 2.252E-11 13 393
20 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process 2.393E-14 1.363E-12 1.038E-11 2.725E-11 9 93
21 GO:0010950 positive regulation of endopeptidase activity 3.725E-14 2.020E-12 1.539E-11 4.242E-11 10 152
22 GO:0052547 regulation of peptidase activity 4.100E-14 2.123E-12 1.617E-11 4.670E-11 13 416
23 GO:0097202 activation of cysteine-type endopeptidase activity 4.697E-14 2.326E-12 1.771E-11 5.349E-11 9 100
24 GO:0009615 response to virus 5.901E-14 2.801E-12 2.133E-11 6.721E-11 13 428
25 GO:0010952 positive regulation of peptidase activity 8.045E-14 3.665E-12 2.791E-11 9.163E-11 10 164
26 GO:0032731 positive regulation of interleukin-1 beta production 8.912E-14 3.904E-12 2.973E-11 1.015E-10 7 34
27 GO:0032611 interleukin-1 beta production 1.044E-13 4.403E-12 3.353E-11 1.189E-10 8 65
28 GO:0050702 interleukin-1 beta secretion 3.068E-13 1.248E-11 9.503E-11 3.494E-10 7 40
29 GO:0032732 positive regulation of interleukin-1 production 4.429E-13 1.734E-11 1.321E-10 5.045E-10 7 42
30 GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 4.568E-13 1.734E-11 1.321E-10 5.203E-10 9 128
31 GO:0031638 zymogen activation 4.905E-13 1.802E-11 1.373E-10 5.587E-10 9 129
32 GO:0070269 pyroptosis 5.082E-13 1.809E-11 1.378E-10 5.789E-10 5 8
33 GO:0032480 negative regulation of type I interferon production 5.284E-13 1.824E-11 1.389E-10 6.019E-10 7 43
34 GO:0032612 interleukin-1 production 5.896E-13 1.975E-11 1.504E-10 6.716E-10 8 80
35 GO:0050701 interleukin-1 secretion 7.425E-13 2.416E-11 1.840E-10 8.457E-10 7 45
36 GO:0032651 regulation of interleukin-1 beta production 2.868E-12 9.075E-11 6.911E-10 3.267E-9 7 54
37 GO:0016485 protein processing 3.666E-12 1.101E-10 8.388E-10 4.176E-9 11 338
38 GO:0050718 positive regulation of interleukin-1 beta secretion 3.675E-12 1.101E-10 8.388E-10 4.186E-9 6 27
39 GO:0050716 positive regulation of interleukin-1 secretion 4.672E-12 1.364E-10 1.039E-9 5.321E-9 6 28
40 GO:0051604 protein maturation 8.665E-12 2.467E-10 1.879E-9 9.870E-9 11 366
41 GO:0050706 regulation of interleukin-1 beta secretion 1.365E-11 3.793E-10 2.889E-9 1.555E-8 6 33
42 GO:0038061 NIK/NF-kappaB signaling 1.528E-11 4.144E-10 3.156E-9 1.741E-8 8 119
43 GO:0032652 regulation of interleukin-1 production 1.718E-11 4.551E-10 3.466E-9 1.957E-8 7 69
44 GO:0002224 toll-like receptor signaling pathway 2.133E-11 5.522E-10 4.206E-9 2.430E-8 8 124
45 GO:0032635 interleukin-6 production 2.758E-11 6.982E-10 5.317E-9 3.142E-8 8 128
46 GO:0050704 regulation of interleukin-1 secretion 2.853E-11 7.064E-10 5.380E-9 3.250E-8 6 37
47 GO:0098586 cellular response to virus 4.694E-11 1.138E-9 8.663E-9 5.347E-8 6 40
48 GO:0051607 defense response to virus 1.240E-10 2.943E-9 2.241E-8 1.413E-7 10 343
49 GO:0001818 negative regulation of cytokine production 1.485E-10 3.451E-9 2.628E-8 1.691E-7 9 243
50 GO:0039528 cytoplasmic pattern recognition receptor signaling pathway in response to virus 1.819E-10 4.144E-9 3.156E-8 2.072E-7 5 21
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 31 input genes in category / 54 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0061702 inflammasome complex 2.340E-20 1.264E-18 5.782E-18 1.264E-18 8 13
2 GO:0044445 cytosolic part 2.368E-12 6.395E-11 2.926E-10 1.279E-10 10 235
3 GO:0032449 CBM complex 3.895E-9 7.011E-8 3.208E-7 2.103E-7 3 3
4 GO:0072558 NLRP1 inflammasome complex 1.556E-8 2.101E-7 9.613E-7 8.404E-7 3 4
5 GO:0097169 AIM2 inflammasome complex 7.764E-8 6.988E-7 3.197E-6 4.193E-6 3 6
6 GO:0072557 IPAF inflammasome complex 7.764E-8 6.988E-7 3.197E-6 4.193E-6 3 6
7 GO:0072559 NLRP3 inflammasome complex 2.169E-7 1.673E-6 7.657E-6 1.171E-5 3 8
8 GO:0008385 IkappaB kinase complex 6.370E-7 4.300E-6 1.967E-5 3.440E-5 3 11
9 GO:0035631 CD40 receptor complex 1.395E-4 8.371E-4 3.830E-3 7.534E-3 2 11
10 GO:0098802 plasma membrane receptor complex 1.983E-4 1.071E-3 4.899E-3 1.071E-2 4 180
11 GO:1902554 serine/threonine protein kinase complex 3.050E-4 1.497E-3 6.850E-3 1.647E-2 3 81
12 GO:0042101 T cell receptor complex 4.303E-4 1.842E-3 8.429E-3 2.323E-2 2 19
13 GO:1902911 protein kinase complex 4.435E-4 1.842E-3 8.429E-3 2.395E-2 3 92
14 GO:0016605 PML body 5.497E-4 2.120E-3 9.701E-3 2.968E-2 3 99
15 GO:0001772 immunological synapse 1.473E-3 5.303E-3 2.426E-2
7.954E-2
 2 35
16 GO:0043235 receptor complex 2.117E-3 6.626E-3 3.032E-2
1.143E-1
 4 339
17 GO:0098857 membrane microdomain 2.209E-3 6.626E-3 3.032E-2
1.193E-1
 4 343
18 GO:0045121 membrane raft 2.209E-3 6.626E-3 3.032E-2
1.193E-1
 4 343
19 GO:0005876 spindle microtubule 4.273E-3 1.214E-2
5.556E-2
2.307E-1
 2 60
20 GO:0061695 transferase complex, transferring phosphorus-containing groups 7.149E-3 1.838E-2
8.411E-2
3.860E-1
 3 244
21 GO:0016323 basolateral plasma membrane 7.149E-3 1.838E-2
8.411E-2
3.860E-1
 3 244
22 GO:0046696 lipopolysaccharide receptor complex 9.720E-3 2.386E-2
1.092E-1
5.249E-1
 1 6
23 GO:0016604 nuclear body 2.091E-2 4.909E-2
2.246E-1
1.000E0
 3 364
Show 18 more annotations

4: Human Phenotype [Display Chart] 22 input genes in category / 1023 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0012123 Posterior uveitis 4.443E-8 4.546E-5 3.413E-4 4.546E-5 4 9
2 HP:0045038 Gastric lymphoma 8.812E-7 4.507E-4 3.384E-3 9.015E-4 3 5
3 HP:0012191 B-cell lymphoma 1.428E-5 1.827E-3 1.372E-2 1.461E-2 3 11
4 HP:0003999 Abnormality of radial epiphyses 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
5 HP:0006353 Hypoplasia of the tooth germ 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
6 HP:0005303 Aortic arch calcification 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
7 HP:0006386 Hypoplastic distal radial epiphyses 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
8 HP:0006112 Expanded phalanges with widened medullary cavities 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
9 HP:0010597 Abnormality of the distal radial epiphysis 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
10 HP:0008102 Expanded metatarsals with widened medullary cavities 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
11 HP:0006232 Expanded metacarpals with widened medullary cavities 2.086E-5 1.827E-3 1.372E-2 2.134E-2 2 2
12 HP:0000554 Uveitis 2.143E-5 1.827E-3 1.372E-2 2.193E-2 6 131
13 HP:0003346 Abnormal immunological laboratory finding 7.178E-5 5.649E-3 4.241E-2
7.344E-2
 8 330
14 HP:0100533 Inflammatory abnormality of the eye 1.265E-4 9.245E-3
6.942E-2
1.294E-1
 7 262
15 HP:0100032 Immunoglobulin abnormality 1.965E-4 1.209E-2
9.080E-2
2.011E-1
 7 281
16 HP:0010701 Abnormal immunoglobulin level 1.965E-4 1.209E-2
9.080E-2
2.011E-1
 7 281
17 HP:0005372 Abnormality of B cell physiology 2.010E-4 1.209E-2
9.080E-2
2.056E-1
 7 282
18 HP:0004962 Thoracic aorta calcification 3.093E-4 1.665E-2
1.250E-1
3.164E-1
 2 6
19 HP:0100550 Tendon rupture 3.093E-4 1.665E-2
1.250E-1
3.164E-1
 2 6
20 HP:0002633 Vasculitis 3.414E-4 1.746E-2
1.311E-1
3.492E-1
 6 215
21 HP:0011123 Inflammatory abnormality of the skin 3.660E-4 1.783E-2
1.339E-1
3.744E-1
 8 416
22 HP:0012378 Fatigue 4.150E-4 1.921E-2
1.442E-1
4.246E-1
 7 317
23 HP:0030043 Hip subluxation 4.318E-4 1.921E-2
1.442E-1
4.418E-1
 2 7
24 HP:0000614 Abnormal nasolacrimal system morphology 4.929E-4 2.101E-2
1.577E-1
5.042E-1
 4 82
25 HP:0001287 Meningitis 6.311E-4 2.583E-2
1.939E-1
6.457E-1
 6 241
26 HP:0011122 Abnormality of skin physiology 7.705E-4 3.032E-2
2.276E-1
7.882E-1
 8 464
27 HP:0001369 Arthritis 8.402E-4 3.184E-2
2.390E-1
8.596E-1
 7 356
28 HP:0012534 Dysesthesia 9.175E-4 3.264E-2
2.450E-1
9.386E-1
 2 10
29 HP:0011450 Unusual CNS infection 9.252E-4 3.264E-2
2.450E-1
9.464E-1
 6 259
30 HP:0001945 Fever 1.051E-3 3.584E-2
2.691E-1
1.000E0
 8 486
31 HP:0000509 Conjunctivitis 1.126E-3 3.600E-2
2.703E-1
1.000E0
 4 102
32 HP:0025337 Red eye 1.126E-3 3.600E-2
2.703E-1
1.000E0
 4 102
33 HP:0002716 Lymphadenopathy 1.292E-3 3.645E-2
2.737E-1
1.000E0
 6 276
34 HP:0005368 Abnormality of humoral immunity 1.300E-3 3.645E-2
2.737E-1
1.000E0
 7 383
35 HP:0004382 Mitral valve calcification 1.338E-3 3.645E-2
2.737E-1
1.000E0
 2 12
36 HP:0004380 Aortic valve calcification 1.338E-3 3.645E-2
2.737E-1
1.000E0
 2 12
37 HP:0003182 Shallow acetabular fossae 1.338E-3 3.645E-2
2.737E-1
1.000E0
 2 12
38 HP:0000971 Abnormality of the sweat gland 1.419E-3 3.645E-2
2.737E-1
1.000E0
 6 281
39 HP:0001045 Vitiligo 1.421E-3 3.645E-2
2.737E-1
1.000E0
 3 49
40 HP:0002846 Abnormal B cell morphology 1.425E-3 3.645E-2
2.737E-1
1.000E0
 7 389
41 HP:0002733 Abnormality of the lymph nodes 1.499E-3 3.741E-2
2.808E-1
1.000E0
 6 284
42 HP:0004313 Decreased antibody level in blood 1.836E-3 4.471E-2
3.357E-1
1.000E0
 5 198
43 HP:0005195 Polyarticular arthropathy 2.111E-3 4.661E-2
3.499E-1
1.000E0
 2 15
44 HP:0004963 Calcification of the aorta 2.111E-3 4.661E-2
3.499E-1
1.000E0
 2 15
45 HP:0000706 Unerupted tooth 2.111E-3 4.661E-2
3.499E-1
1.000E0
 2 15
46 HP:0005764 Polyarticular arthritis 2.111E-3 4.661E-2
3.499E-1
1.000E0
 2 15
47 HP:0010783 Erythema 2.141E-3 4.661E-2
3.499E-1
1.000E0
 5 205
Show 42 more annotations

5: Mouse Phenotype [Display Chart] 29 input genes in category / 932 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008568 abnormal interleukin secretion 7.453E-19 6.946E-16 5.150E-15 6.946E-16 19 495
2 MP:0002406 increased susceptibility to infection 4.685E-18 2.183E-15 1.619E-14 4.367E-15 18 449
3 MP:0002451 abnormal macrophage physiology 7.718E-14 2.398E-11 1.778E-10 7.193E-11 15 434
4 MP:0008656 abnormal interleukin-1 beta secretion 1.473E-12 3.431E-10 2.544E-9 1.373E-9 9 89
5 MP:0008713 abnormal cytokine level 2.139E-12 3.987E-10 2.957E-9 1.994E-9 14 439
6 MP:0008650 abnormal interleukin-1 secretion 2.694E-12 4.184E-10 3.103E-9 2.511E-9 9 95
7 MP:0008835 abnormal intercellular signaling peptide or protein level 3.180E-12 4.234E-10 3.139E-9 2.964E-9 14 452
8 MP:0008636 decreased circulating interleukin-18 level 2.990E-11 3.484E-9 2.583E-8 2.787E-8 5 10
9 MP:0008704 abnormal interleukin-6 secretion 4.090E-11 4.235E-9 3.141E-8 3.812E-8 10 186
10 MP:0008683 abnormal interleukin-18 secretion 5.471E-11 4.945E-9 3.667E-8 5.099E-8 5 11
11 MP:0002418 increased susceptibility to viral infection 5.837E-11 4.945E-9 3.667E-8 5.440E-8 9 133
12 MP:0008706 decreased interleukin-6 secretion 1.755E-10 1.358E-8 1.007E-7 1.636E-7 8 98
13 MP:0008751 abnormal interleukin level 1.894E-10 1.358E-8 1.007E-7 1.765E-7 11 296
14 MP:0020174 abnormal IgG level 3.668E-10 2.442E-8 1.811E-7 3.418E-7 12 411
15 MP:0008555 abnormal interferon secretion 4.355E-10 2.706E-8 2.007E-7 4.059E-7 11 320
16 MP:0010210 abnormal circulating cytokine level 6.868E-10 4.001E-8 2.967E-7 6.401E-7 11 334
17 MP:0008588 abnormal circulating interleukin level 8.134E-10 4.459E-8 3.307E-7 7.581E-7 10 252
18 MP:0020185 altered susceptibility to viral infection 9.253E-10 4.791E-8 3.553E-7 8.624E-7 9 181
19 MP:0002412 increased susceptibility to bacterial infection 1.188E-9 5.829E-8 4.323E-7 1.108E-6 10 262
20 MP:0008634 abnormal circulating interleukin-18 level 1.356E-9 6.039E-8 4.478E-7 1.264E-6 5 19
21 MP:0008658 decreased interleukin-1 beta secretion 1.361E-9 6.039E-8 4.478E-7 1.268E-6 6 42
22 MP:0008685 decreased interleukin-18 secretion 1.726E-9 7.313E-8 5.423E-7 1.609E-6 4 7
23 MP:0008564 increased interferon-beta secretion 3.446E-9 1.396E-7 1.035E-6 3.211E-6 4 8
24 MP:0008556 abnormal tumor necrosis factor secretion 9.953E-9 3.865E-7 2.866E-6 9.277E-6 9 237
25 MP:0002376 abnormal dendritic cell physiology 1.305E-8 4.652E-7 3.450E-6 1.216E-5 8 168
26 MP:0002498 abnormal acute inflammation 1.348E-8 4.652E-7 3.450E-6 1.256E-5 10 337
27 MP:0020186 altered susceptibility to bacterial infection 1.348E-8 4.652E-7 3.450E-6 1.256E-5 10 337
28 MP:0001805 decreased IgG level 2.305E-8 7.674E-7 5.690E-6 2.149E-5 9 261
29 MP:0008558 abnormal interferon-beta secretion 2.694E-8 8.657E-7 6.419E-6 2.510E-5 5 33
30 MP:0008559 abnormal interferon-gamma secretion 3.859E-8 1.199E-6 8.891E-6 3.597E-5 9 277
31 MP:0008734 decreased susceptibility to endotoxin shock 7.248E-8 2.179E-6 1.616E-5 6.755E-5 6 80
32 MP:0008552 abnormal circulating tumor necrosis factor level 1.154E-7 3.362E-6 2.493E-5 1.076E-4 7 146
33 MP:0010377 abnormal gut flora balance 1.868E-7 5.275E-6 3.912E-5 1.741E-4 4 19
34 MP:0020180 abnormal IgM level 2.298E-7 6.259E-6 4.641E-5 2.141E-4 8 243
35 MP:0002460 decreased immunoglobulin level 2.351E-7 6.259E-6 4.641E-5 2.191E-4 9 342
36 MP:0002144 abnormal B cell differentiation 2.659E-7 6.884E-6 5.104E-5 2.478E-4 9 347
37 MP:0008567 decreased interferon-gamma secretion 3.683E-7 9.278E-6 6.880E-5 3.433E-4 7 173
38 MP:0008752 abnormal tumor necrosis factor level 6.473E-7 1.588E-5 1.177E-4 6.033E-4 7 188
39 MP:0005087 decreased acute inflammation 8.875E-7 2.121E-5 1.573E-4 8.271E-4 7 197
40 MP:0001844 autoimmune response 1.299E-6 3.027E-5 2.244E-4 1.211E-3 9 419
41 MP:0005005 abnormal self tolerance 1.352E-6 3.028E-5 2.245E-4 1.260E-3 9 421
42 MP:0008561 decreased tumor necrosis factor secretion 1.430E-6 3.028E-5 2.245E-4 1.332E-3 6 132
43 MP:0020171 abnormal IgA level 1.430E-6 3.028E-5 2.245E-4 1.332E-3 6 132
44 MP:0008750 abnormal interferon level 1.430E-6 3.028E-5 2.245E-4 1.332E-3 6 132
45 MP:0002495 increased IgA level 1.472E-6 3.050E-5 2.261E-4 1.372E-3 5 72
46 MP:0009787 increased susceptibility to infection induced morbidity/mortality 1.561E-6 3.135E-5 2.325E-4 1.455E-3 6 134
47 MP:0005000 abnormal immune tolerance 1.581E-6 3.135E-5 2.325E-4 1.473E-3 9 429
48 MP:0008655 decreased interleukin-1 alpha secretion 1.640E-6 3.185E-5 2.362E-4 1.529E-3 3 9
49 MP:0003103 liver degeneration 1.919E-6 3.606E-5 2.674E-4 1.789E-3 4 33
50 MP:0013296 abnormal susceptibility to induced colitis 1.935E-6 3.606E-5 2.674E-4 1.803E-3 6 139
Show 45 more annotations

6: Domain [Display Chart] 32 input genes in category / 116 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1.10.533.10 - Gene3D 1.424E-47 1.652E-45 8.814E-45 1.652E-45 23 93
2 IPR011029 DEATH-like dom InterPro 7.279E-47 4.222E-45 2.252E-44 8.444E-45 23 99
3 IPR001315 CARD InterPro 1.232E-41 4.764E-40 2.542E-39 1.429E-39 17 31
4 PS50209 CARD PROSITE 5.413E-41 1.570E-39 8.375E-39 6.279E-39 17 33
5 PF00619 CARD Pfam 1.655E-39 3.840E-38 2.049E-37 1.920E-37 16 28
6 IPR007111 NACHT NTPase InterPro 6.911E-26 1.145E-24 6.110E-24 8.017E-24 11 23
7 PS50837 NACHT PROSITE 6.911E-26 1.145E-24 6.110E-24 8.017E-24 11 23
8 PF02758 PYRIN Pfam 3.513E-15 3.704E-14 1.976E-13 4.075E-13 7 22
9 IPR004020 DAPIN InterPro 3.513E-15 3.704E-14 1.976E-13 4.075E-13 7 22
10 SM01289 PYRIN SMART 3.513E-15 3.704E-14 1.976E-13 4.075E-13 7 22
11 PS50824 DAPIN PROSITE 3.513E-15 3.704E-14 1.976E-13 4.075E-13 7 22
12 SM00114 CARD SMART 1.195E-13 1.155E-12 6.162E-12 1.386E-11 6 16
13 3.80.10.10 - Gene3D 8.759E-11 7.816E-10 4.170E-9 1.016E-8 10 321
14 IPR032675 L dom-like InterPro 1.082E-10 8.964E-10 4.783E-9 1.255E-8 10 328
15 PF13516 LRR 6 Pfam 4.129E-10 3.193E-9 1.704E-8 4.790E-8 6 55
16 PF11648 RIG-I C-RD Pfam 4.526E-9 2.917E-8 1.556E-7 5.250E-7 3 3
17 PS51789 RLR CTR PROSITE 4.526E-9 2.917E-8 1.556E-7 5.250E-7 3 3
18 IPR021673 RIG-I C-RD InterPro 4.526E-9 2.917E-8 1.556E-7 5.250E-7 3 3
19 3.40.50.1460 - Gene3D 1.627E-6 8.577E-6 4.576E-5 1.887E-4 3 14
20 IPR001309 Pept C14 p20 InterPro 1.627E-6 8.577E-6 4.576E-5 1.887E-4 3 14
21 IPR029030 Caspase-like dom InterPro 1.627E-6 8.577E-6 4.576E-5 1.887E-4 3 14
22 PS50208 CASPASE P20 PROSITE 1.627E-6 8.577E-6 4.576E-5 1.887E-4 3 14
23 SM01239 IKKbetaNEMObind SMART 2.826E-6 1.311E-5 6.997E-5 3.279E-4 2 2
24 PF12179 IKKbetaNEMObind Pfam 2.826E-6 1.311E-5 6.997E-5 3.279E-4 2 2
25 IPR022007 IKKbetaNEMObind InterPro 2.826E-6 1.311E-5 6.997E-5 3.279E-4 2 2
26 IPR001611 Leu-rich rpt InterPro 5.726E-6 2.555E-5 1.363E-4 6.642E-4 6 271
27 PF16739 CARD 2 Pfam 8.470E-6 3.509E-5 1.872E-4 9.825E-4 2 3
28 IPR031964 CARD dom InterPro 8.470E-6 3.509E-5 1.872E-4 9.825E-4 2 3
29 IPR017350 Pept C14A CASP1-typ InterPro 5.904E-5 2.361E-4 1.260E-3 6.848E-3 2 7
30 PF04851 ResIII Pfam 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
31 PF00653 BIR Pfam 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
32 PS01282 BIR REPEAT 1 PROSITE 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
33 PS50143 BIR REPEAT 2 PROSITE 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
34 SM00238 BIR SMART 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
35 IPR006935 Helicase/UvrB N InterPro 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
36 1.10.1170.10 - Gene3D 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
37 IPR001370 BIR rpt InterPro 7.863E-5 2.465E-4 1.315E-3 9.121E-3 2 8
38 PS01121 CASPASE HIS PROSITE 1.540E-4 4.700E-4 2.507E-3 1.786E-2 2 11
39 IPR002138 Pept C14 p10 InterPro 1.846E-4 4.979E-4 2.656E-3 2.141E-2 2 12
40 IPR033139 Caspase cys AS InterPro 1.846E-4 4.979E-4 2.656E-3 2.141E-2 2 12
41 IPR016129 Caspase his AS InterPro 1.846E-4 4.979E-4 2.656E-3 2.141E-2 2 12
42 PS01122 CASPASE CYS PROSITE 1.846E-4 4.979E-4 2.656E-3 2.141E-2 2 12
43 PS50207 CASPASE P10 PROSITE 1.846E-4 4.979E-4 2.656E-3 2.141E-2 2 12
44 IPR015917 Pept C14A InterPro 2.179E-4 5.617E-4 2.996E-3 2.527E-2 2 13
45 SM00115 CASc SMART 2.179E-4 5.617E-4 2.996E-3 2.527E-2 2 13
46 PS00856 GUANYLATE KINASE 1 PROSITE 6.992E-4 1.726E-3 9.207E-3
8.111E-2
 2 23
47 PS50052 GUANYLATE KINASE 2 PROSITE 6.992E-4 1.726E-3 9.207E-3
8.111E-2
 2 23
48 SM00490 HELICc SMART 7.963E-4 1.839E-3 9.812E-3
9.237E-2
 3 107
49 PF00271 Helicase C Pfam 7.963E-4 1.839E-3 9.812E-3
9.237E-2
 3 107
50 IPR001650 Helicase C InterPro 8.181E-4 1.839E-3 9.812E-3
9.490E-2
 3 108
Show 45 more annotations

7: Pathway [Display Chart] 30 input genes in category / 243 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 122191 NOD-like receptor signaling pathway BioSystems: KEGG 8.158E-27 1.983E-24 1.204E-23 1.983E-24 18 170
2 1269251 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways BioSystems: REACTOME 8.020E-25 9.744E-23 5.917E-22 1.949E-22 13 48
3 1269252 NOD1/2 Signaling Pathway BioSystems: REACTOME 4.150E-15 3.362E-13 2.041E-12 1.008E-12 8 32
4 634527 NF-kappa B signaling pathway BioSystems: KEGG 7.467E-13 4.536E-11 2.755E-10 1.815E-10 9 95
5 1269253 Inflammasomes BioSystems: REACTOME 1.397E-12 6.725E-11 4.084E-10 3.394E-10 6 17
6 125137 Cytosolic DNA-sensing pathway BioSystems: KEGG 1.660E-12 6.725E-11 4.084E-10 4.035E-10 8 64
7 117292 RIG-I-like receptor signaling pathway BioSystems: KEGG 3.508E-12 1.218E-10 7.395E-10 8.525E-10 8 70
8 217173 Influenza A BioSystems: KEGG 4.886E-12 1.484E-10 9.012E-10 1.187E-9 10 173
9 1269259 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways BioSystems: REACTOME 1.585E-11 4.279E-10 2.598E-9 3.851E-9 8 84
10 138030 Canonical NF-kappaB pathway BioSystems: Pathway Interaction Database 1.868E-9 4.539E-8 2.756E-7 4.539E-7 5 23
11 1269220 MyD88-independent TLR3/TLR4 cascade BioSystems: REACTOME 2.843E-9 5.313E-8 3.226E-7 6.907E-7 7 99
12 1269221 TRIF-mediated TLR3/TLR4 signaling BioSystems: REACTOME 2.843E-9 5.313E-8 3.226E-7 6.907E-7 7 99
13 1269219 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 2.843E-9 5.313E-8 3.226E-7 6.907E-7 7 99
14 1269304 CLEC7A (Dectin-1) signaling BioSystems: REACTOME 3.759E-9 6.524E-8 3.962E-7 9.134E-7 7 103
15 1269236 Activated TLR4 signalling BioSystems: REACTOME 8.151E-9 1.320E-7 8.018E-7 1.981E-6 7 115
16 1269257 The AIM2 inflammasome BioSystems: REACTOME 1.263E-8 1.912E-7 1.161E-6 3.068E-6 3 3
17 1383069 TP53 Regulates Transcription of Caspase Activators and Caspases BioSystems: REACTOME 1.338E-8 1.912E-7 1.161E-6 3.251E-6 4 12
18 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 1.543E-8 2.083E-7 1.265E-6 3.749E-6 7 126
19 1269261 NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 BioSystems: REACTOME 1.929E-8 2.467E-7 1.498E-6 4.688E-6 4 13
20 1269264 Negative regulators of RIG-I/MDA5 signaling BioSystems: REACTOME 2.048E-8 2.488E-7 1.511E-6 4.976E-6 5 36
21 1269303 C-type lectin receptors (CLRs) BioSystems: REACTOME 4.496E-8 5.202E-7 3.159E-6 1.092E-5 7 147
22 1269260 TRAF3-dependent IRF activation pathway BioSystems: REACTOME 4.886E-8 5.396E-7 3.277E-6 1.187E-5 4 16
23 1269204 Toll-Like Receptors Cascades BioSystems: REACTOME 5.925E-8 6.260E-7 3.801E-6 1.440E-5 7 153
24 138055 TCR signaling in naive CD8+ T cells BioSystems: Pathway Interaction Database 9.116E-8 9.230E-7 5.605E-6 2.215E-5 5 48
25 137998 TCR signaling in naive CD4+ T cells BioSystems: Pathway Interaction Database 2.850E-7 2.770E-6 1.682E-5 6.925E-5 5 60
26 M9670 TNF/Stress Related Signaling MSigDB C2 BIOCARTA (v6.0) 3.345E-7 3.011E-6 1.828E-5 8.129E-5 4 25
27 1269263 TRAF6 mediated NF-kB activation BioSystems: REACTOME 3.345E-7 3.011E-6 1.828E-5 8.129E-5 4 25
28 138058 BCR signaling pathway BioSystems: Pathway Interaction Database 4.616E-7 4.006E-6 2.433E-5 1.122E-4 5 66
29 1269186 Activation of NF-kappaB in B cells BioSystems: REACTOME 6.210E-7 5.053E-6 3.069E-5 1.509E-4 5 70
30 1269210 TAK1 activates NFkB by phosphorylation and activation of IKKs complex BioSystems: REACTOME 6.239E-7 5.053E-6 3.069E-5 1.516E-4 4 29
31 83081 B cell receptor signaling pathway BioSystems: KEGG 6.669E-7 5.228E-6 3.174E-5 1.621E-4 5 71
32 694606 Hepatitis B BioSystems: KEGG 1.019E-6 7.736E-6 4.698E-5 2.476E-4 6 144
33 1269262 TRAF6 mediated IRF7 activation BioSystems: REACTOME 1.362E-6 9.732E-6 5.909E-5 3.309E-4 4 35
34 137995 HIV-1 Nef: Negative effector of Fas and TNF-alpha BioSystems: Pathway Interaction Database 1.362E-6 9.732E-6 5.909E-5 3.309E-4 4 35
35 1427863 Ovarian tumor domain proteases BioSystems: REACTOME 1.712E-6 1.188E-5 7.217E-5 4.160E-4 4 37
36 1269301 FCERI mediated NF-kB activation BioSystems: REACTOME 1.843E-6 1.244E-5 7.552E-5 4.477E-4 5 87
37 1269254 The NLRP3 inflammasome BioSystems: REACTOME 2.737E-6 1.798E-5 1.092E-4 6.652E-4 3 12
38 1383066 TP53 Regulates Transcription of Cell Death Genes BioSystems: REACTOME 3.810E-6 2.437E-5 1.480E-4 9.259E-4 4 45
39 1269320 Interleukin-1 signaling BioSystems: REACTOME 4.166E-6 2.519E-5 1.529E-4 1.012E-3 4 46
40 83080 T cell receptor signaling pathway BioSystems: KEGG 4.250E-6 2.519E-5 1.529E-4 1.033E-3 5 103
41 1269176 Downstream TCR signaling BioSystems: REACTOME 4.250E-6 2.519E-5 1.529E-4 1.033E-3 5 103
42 377873 Herpes simplex infection BioSystems: KEGG 4.381E-6 2.535E-5 1.539E-4 1.065E-3 6 185
43 1269256 The IPAF inflammasome BioSystems: REACTOME 5.613E-6 3.154E-5 1.915E-4 1.364E-3 2 2
44 137974 Caspase cascade in apoptosis BioSystems: Pathway Interaction Database 5.841E-6 3.154E-5 1.915E-4 1.419E-3 4 50
45 P00054 Toll receptor signaling pathway PantherDB 5.841E-6 3.154E-5 1.915E-4 1.419E-3 4 50
46 469200 Legionellosis BioSystems: KEGG 8.577E-6 4.531E-5 2.751E-4 2.084E-3 4 55
47 1269172 TCR signaling BioSystems: REACTOME 1.055E-5 5.375E-5 3.264E-4 2.564E-3 5 124
48 M13968 HIV-I Nef: negative effector of Fas and TNF MSigDB C2 BIOCARTA (v6.0) 1.062E-5 5.375E-5 3.264E-4 2.580E-3 4 58
49 173973 Hepatitis C BioSystems: KEGG 1.378E-5 6.835E-5 4.151E-4 3.349E-3 5 131
50 213306 Measles BioSystems: KEGG 1.538E-5 7.477E-5 4.540E-4 3.739E-3 5 134
Show 45 more annotations

8: Pubmed [Display Chart] 32 input genes in category / 7417 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12819136 Comparative analysis of apoptosis and inflammation genes of mice and humans. Pubmed 3.332E-28 2.472E-24 2.345E-23 2.472E-24 13 71
2 22002608 Non-canonical inflammasome activation targets caspase-11. Pubmed 1.544E-23 5.726E-20 5.434E-19 1.145E-19 8 11
3 15107016 Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Pubmed 5.149E-21 1.273E-17 1.208E-16 3.819E-17 7 9
4 21565393 NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Pubmed 1.131E-19 2.097E-16 1.989E-15 8.387E-16 7 12
5 19915568 Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Pubmed 2.449E-19 3.632E-16 3.446E-15 1.816E-15 7 13
6 22801494 Novel role of PKR in inflammasome activation and HMGB1 release. Pubmed 1.471E-18 1.511E-15 1.434E-14 1.091E-14 6 7
7 17620097 Polymorphisms in NACHT-LRR (NLR) genes in atopic dermatitis. Pubmed 1.471E-18 1.511E-15 1.434E-14 1.091E-14 6 7
8 23630357 Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. Pubmed 1.630E-18 1.511E-15 1.434E-14 1.209E-14 7 16
9 23064150 RIG-I detects infection with live Listeria by sensing secreted bacterial nucleic acids. Pubmed 5.881E-18 4.847E-15 4.599E-14 4.362E-14 6 8
10 20348425 Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling. Pubmed 1.763E-17 1.308E-14 1.241E-13 1.308E-13 6 9
11 26572062 Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock. Pubmed 4.406E-17 2.971E-14 2.819E-13 3.268E-13 6 10
12 28636595 Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Pubmed 9.687E-17 5.987E-14 5.681E-13 7.185E-13 6 11
13 27670879 CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages. Pubmed 2.974E-16 1.298E-13 1.231E-12 2.206E-12 5 5
14 21978001 NOD-like receptors and RIG-I-like receptors in human eosinophils: activation by NOD1 and NOD2 agonists. Pubmed 2.974E-16 1.298E-13 1.231E-12 2.206E-12 5 5
15 11259443 Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B. Pubmed 2.974E-16 1.298E-13 1.231E-12 2.206E-12 5 5
16 11472070 CLAN, a novel human CED-4-like gene. Pubmed 2.974E-16 1.298E-13 1.231E-12 2.206E-12 5 5
17 16407890 Cryopyrin activates the inflammasome in response to toxins and ATP. Pubmed 2.974E-16 1.298E-13 1.231E-12 2.206E-12 5 5
18 27617861 NLRC4 suppresses melanoma tumor progression independently of inflammasome activation. Pubmed 1.784E-15 6.299E-13 5.977E-12 1.323E-11 5 6
19 16177806 Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Pubmed 1.784E-15 6.299E-13 5.977E-12 1.323E-11 5 6
20 24919149 Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Pubmed 1.784E-15 6.299E-13 5.977E-12 1.323E-11 5 6
21 24516390 Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ. Pubmed 1.784E-15 6.299E-13 5.977E-12 1.323E-11 5 6
22 22365665 Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation. Pubmed 3.877E-15 1.307E-12 1.240E-11 2.875E-11 6 18
23 18511561 A NOD2-NALP1 complex mediates caspase-1-dependent IL-1beta secretion in response to Bacillus anthracis infection and muramyl dipeptide. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
24 19158675 AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
25 20457908 Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
26 15817483 PYPAF3, a PYRIN-containing APAF-1-like protein, is a feedback regulator of caspase-1-dependent interleukin-1beta secretion. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
27 15184390 Physical and functional interaction of CARMA1 and CARMA3 with Ikappa kinase gamma-NFkappaB essential modulator. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
28 23115038 Francisella tularensis live vaccine strain folate metabolism and pseudouridine synthase gene mutants modulate macrophage caspase-1 activation. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
29 23818043 The Cag pathogenicity island and interaction between TLR2/NOD2 and NLRP3 regulate IL-1β production in Helicobacter pylori infected dendritic cells. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
30 23645208 AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
31 22905357 Addendum: defective Dock2 expression in a subset of ASC-deficient mouse lines. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
32 17403772 MDP-induced interleukin-1beta processing requires Nod2 and CIAS1/NALP3. Pubmed 6.239E-15 1.446E-12 1.372E-11 4.627E-11 5 7
33 22101787 Activation of the NLRP3 inflammasome by Mycobacterium tuberculosis is uncoupled from susceptibility to active tuberculosis. Pubmed 1.663E-14 3.333E-12 3.163E-11 1.233E-10 5 8
34 23460746 Critical role of ASC inflammasomes and bacterial type IV secretion system in caspase-1 activation and host innate resistance to Brucella abortus infection. Pubmed 1.663E-14 3.333E-12 3.163E-11 1.233E-10 5 8
35 27846608 The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Pubmed 1.663E-14 3.333E-12 3.163E-11 1.233E-10 5 8
36 19339971 Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Pubmed 1.663E-14 3.333E-12 3.163E-11 1.233E-10 5 8
37 29033131 Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Pubmed 1.663E-14 3.333E-12 3.163E-11 1.233E-10 5 8
38 22911706 Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1β and IL-18 secretion but not to pyroptosis. Pubmed 3.739E-14 7.298E-12 6.924E-11 2.773E-10 5 9
39 29030458 A noncanonical function of cGAMP in inflammasome priming and activation. Pubmed 7.473E-14 1.421E-11 1.349E-10 5.543E-10 5 10
40 25748427 MALT1-ubiquitination triggers non-genomic NF-κB/IKK signaling upon platelet activation. Pubmed 1.369E-13 2.362E-11 2.241E-10 1.016E-9 5 11
41 17433728 Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Pubmed 1.369E-13 2.362E-11 2.241E-10 1.016E-9 5 11
42 17047224 Regulation and function of IKK and IKK-related kinases. Pubmed 1.369E-13 2.362E-11 2.241E-10 1.016E-9 5 11
43 23007157 IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation. Pubmed 1.369E-13 2.362E-11 2.241E-10 1.016E-9 5 11
44 17363905 Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. Pubmed 2.346E-13 3.867E-11 3.669E-10 1.740E-9 5 12
45 23887873 Noncanonical inflammasome activation by intracellular LPS independent of TLR4. Pubmed 2.346E-13 3.867E-11 3.669E-10 1.740E-9 5 12
46 26008898 Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1β. Pubmed 3.810E-13 4.122E-11 3.911E-10 2.826E-9 5 13
47 21037094 Differential regulation of caspase-1 activation via NLRP3/NLRC4 inflammasomes mediated by aerolysin and type III secretion system during Aeromonas veronii infection. Pubmed 4.057E-13 4.122E-11 3.911E-10 3.009E-9 4 4
48 21957143 Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection. Pubmed 4.057E-13 4.122E-11 3.911E-10 3.009E-9 4 4
49 19237518 Asc and Ipaf Inflammasomes direct distinct pathways for caspase-1 activation in response to Legionella pneumophila. Pubmed 4.057E-13 4.122E-11 3.911E-10 3.009E-9 4 4
50 26902715 Transcription Profiling of NOD-like Receptors in the Human Cornea with Disease. Pubmed 4.057E-13 4.122E-11 3.911E-10 3.009E-9 4 4
Show 45 more annotations

9: Interaction [Display Chart] 32 input genes in category / 885 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NLRC4 NLRC4 interactions 2.968E-22 2.627E-19 1.934E-18 2.627E-19 9 15
2 int:BCL10 BCL10 interactions 1.537E-17 6.802E-15 5.009E-14 1.360E-14 10 66
3 int:PYCARD PYCARD interactions 3.696E-14 1.090E-11 8.029E-11 3.271E-11 8 53
4 int:IKBKG IKBKG interactions 4.841E-13 9.658E-11 7.111E-10 4.284E-10 12 351
5 int:CASP8 CASP8 interactions 5.456E-13 9.658E-11 7.111E-10 4.829E-10 10 182
6 int:NLRP1 NLRP1 interactions 8.079E-13 1.192E-10 8.775E-10 7.150E-10 6 20
7 int:NOD1 NOD1 interactions 7.774E-12 8.798E-10 6.478E-9 6.880E-9 6 28
8 int:MAVS MAVS interactions 7.953E-12 8.798E-10 6.478E-9 7.038E-9 8 101
9 int:TNFAIP3 TNFAIP3 interactions 9.334E-12 9.178E-10 6.758E-9 8.261E-9 8 103
10 int:IKBKB IKBKB interactions 1.447E-11 1.281E-9 9.432E-9 1.281E-8 9 172
11 int:CASP1 CASP1 interactions 1.609E-11 1.294E-9 9.532E-9 1.424E-8 7 63
12 int:TRAF6 TRAF6 interactions 2.095E-11 1.545E-9 1.138E-8 1.854E-8 11 364
13 int:MALT1 MALT1 interactions 9.127E-11 6.214E-9 4.575E-8 8.078E-8 6 41
14 int:NLRC5 NLRC5 interactions 1.315E-10 8.314E-9 6.122E-8 1.164E-7 4 6
15 int:CHUK CHUK interactions 3.267E-10 1.928E-8 1.419E-7 2.891E-7 8 160
16 int:BIRC3 BIRC3 interactions 5.483E-10 3.010E-8 2.216E-7 4.853E-7 7 103
17 int:RIPK2 RIPK2 interactions 5.782E-10 3.010E-8 2.216E-7 5.117E-7 6 55
18 int:CASP9 CASP9 interactions 7.219E-10 3.549E-8 2.614E-7 6.389E-7 6 57
19 int:TRIM40 TRIM40 interactions 1.101E-9 5.126E-8 3.775E-7 9.740E-7 4 9
20 int:NOD2 NOD2 interactions 5.040E-9 2.230E-7 1.642E-6 4.460E-6 5 36
21 int:IKBKE IKBKE interactions 6.264E-9 2.640E-7 1.944E-6 5.543E-6 6 81
22 int:RBCK1 RBCK1 interactions 9.017E-9 3.627E-7 2.671E-6 7.980E-6 6 86
23 int:TRAF2 TRAF2 interactions 1.126E-8 4.092E-7 3.013E-6 9.966E-6 9 365
24 int:CASP2 CASP2 interactions 1.129E-8 4.092E-7 3.013E-6 9.988E-6 5 42
25 int:RIPK1 RIPK1 interactions 1.188E-8 4.092E-7 3.013E-6 1.051E-5 6 90
26 int:XIAP XIAP interactions 1.202E-8 4.092E-7 3.013E-6 1.064E-5 7 160
27 int:MAP3K7 MAP3K7 interactions 1.427E-8 4.676E-7 3.443E-6 1.263E-5 7 164
28 int:PRKCQ PRKCQ interactions 1.615E-8 5.103E-7 3.758E-6 1.429E-5 5 45
29 int:TNFRSF1A TNFRSF1A interactions 2.325E-8 7.095E-7 5.224E-6 2.057E-5 7 176
30 int:TANK TANK interactions 4.539E-8 1.339E-6 9.860E-6 4.017E-5 5 55
31 int:RNF31 RNF31 interactions 5.200E-8 1.485E-6 1.093E-5 4.602E-5 8 305
32 int:TRAF3 TRAF3 interactions 1.753E-7 4.849E-6 3.570E-5 1.552E-4 6 141
33 int:NLRP4 NLRP4 interactions 2.986E-7 8.008E-6 5.896E-5 2.643E-4 3 8
34 int:CARD11 CARD11 interactions 3.467E-7 9.025E-6 6.645E-5 3.068E-4 4 33
35 int:IRF5 IRF5 interactions 4.425E-7 1.119E-5 8.239E-5 3.916E-4 4 35
36 int:NFKBIA NFKBIA interactions 4.933E-7 1.213E-5 8.930E-5 4.366E-4 6 168
37 int:TRAF3IP2 TRAF3IP2 interactions 5.568E-7 1.332E-5 9.806E-5 4.927E-4 4 37
38 int:CARD14 CARD14 interactions 6.383E-7 1.448E-5 1.067E-4 5.649E-4 3 10
39 int:IRGM IRGM interactions 6.383E-7 1.448E-5 1.067E-4 5.649E-4 3 10
40 int:DDX60 DDX60 interactions 8.766E-7 1.939E-5 1.428E-4 7.757E-4 3 11
41 int:TRADD TRADD interactions 1.485E-6 3.205E-5 2.360E-4 1.314E-3 4 47
42 int:CFLAR CFLAR interactions 2.070E-6 4.361E-5 3.211E-4 1.832E-3 4 51
43 int:CD40 CD40 interactions 3.247E-6 6.682E-5 4.920E-4 2.873E-3 4 57
44 int:CARD10 CARD10 interactions 4.298E-6 8.644E-5 6.365E-4 3.804E-3 3 18
45 int:BIRC2 BIRC2 interactions 6.620E-6 1.302E-4 9.587E-4 5.859E-3 5 149
46 int:NLRP2 NLRP2 interactions 9.271E-6 1.746E-4 1.285E-3 8.204E-3 3 23
47 int:DPP4 DPP4 interactions 9.271E-6 1.746E-4 1.285E-3 8.204E-3 3 23
48 int:USP18 USP18 interactions 1.899E-5 3.429E-4 2.525E-3 1.680E-2 3 29
49 int:PELI1 PELI1 interactions 1.899E-5 3.429E-4 2.525E-3 1.680E-2 3 29
50 int:SQSTM1 SQSTM1 interactions 1.959E-5 3.467E-4 2.553E-3 1.733E-2 6 318
Show 45 more annotations

10: Cytoband [Display Chart] 32 input genes in category / 32 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q21.33-q23.1 12q21.33-q23.1 9.232E-4 2.360E-2
9.579E-2
 2.954E-2 1 1
2 7q34-q35 7q34-q35 2.767E-3 2.360E-2
9.579E-2
8.855E-2
 1 3
3 7p15-p14 7p15-p14 3.688E-3 2.360E-2
9.579E-2
1.180E-1
 1 4
4 6p22.3-p22.1 6p22.3-p22.1 3.688E-3 2.360E-2
9.579E-2
1.180E-1
 1 4
5 10q24-q25 10q24-q25 3.688E-3 2.360E-2
9.579E-2
1.180E-1
 1 4
6 2p22-p21 2p22-p21 7.363E-3 3.927E-2
1.594E-1
2.356E-1
 1 8
7 2q24 2q24 1.011E-2 4.044E-2
1.641E-1
3.235E-1
 1 11
8 11q22 11q22 1.011E-2 4.044E-2
1.641E-1
3.235E-1
 1 11
9 16p13 16p13 1.194E-2 4.112E-2
1.669E-1
3.820E-1
 1 13
10 8p11.2 8p11.2 1.285E-2 4.112E-2
1.669E-1
4.112E-1
 1 14
11 18q21 18q21 1.649E-2 4.730E-2
1.920E-1
5.278E-1
 1 18
12 1p22 1p22 1.831E-2 4.730E-2
1.920E-1
5.859E-1
 1 20
13 7p22 7p22 1.922E-2 4.730E-2
1.920E-1
6.149E-1
 1 21
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 15 input genes in category / 62 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 27 input genes in category / 14 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 959 Caspase recruitment domain containing genenames.org 2.748E-40 3.847E-39 1.251E-38 3.847E-39 16 30
2 666 NLR family|Pyrin domain containing genenames.org 3.182E-26 2.227E-25 7.242E-25 4.454E-25 11 25
3 994 Pyrin domain containing|Pyrin and HIN domain family genenames.org 1.022E-12 4.770E-12 1.551E-11 1.431E-11 6 25
4 904 Calcium voltage-gated channel subunits|Membrane associated guanylate kinases genenames.org 7.407E-6 2.593E-5 8.430E-5 1.037E-4 3 26
5 419 Ring finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing genenames.org 5.906E-5 1.654E-4 5.377E-4 8.268E-4 2 8
6 468 Caspases genenames.org 1.638E-4 3.821E-4 1.242E-3 2.293E-3 2 13
7 995 Pyrin domain containing|Pyrin and HIN domain family genenames.org 7.399E-3 1.480E-2 4.812E-2
1.036E-1
 1 5
8 1168 RNA helicases genenames.org 1.621E-2 2.836E-2
9.223E-2
2.269E-1
 1 11
9 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 2.123E-2 3.289E-2
1.069E-1
2.972E-1
 2 152
10 500 DEAH-box helicases genenames.org 2.349E-2 3.289E-2
1.069E-1
3.289E-1
 1 16
Show 5 more annotations

13: Coexpression [Display Chart] 32 input genes in category / 3012 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17682054-Table1 Human Bone Lu07 301genes GeneSigDB 2.765E-15 8.327E-12 7.151E-11 8.327E-12 12 296
2 19412164-TableS2 Human Lymphoma Compagno09 genes GeneSigDB 3.059E-12 4.607E-9 3.956E-8 9.213E-9 6 31
3 M8590 Genes up-regulated in macrophages versus dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 2.104E-9 2.113E-6 1.814E-5 6.338E-6 7 162
4 11573962-Table2 Human Viral Sun01 27genes Apoptosis-Related GeneSigDB 3.734E-8 2.812E-5 2.415E-4 1.125E-4 4 25
5 M8593 Genes up-regulated in macrophages versus those sorted as ITGAX int [GeneID=3687] and EMR1 high [GeneID=2015]. MSigDB C7: Immunologic Signatures (v6.0) 1.114E-7 6.710E-5 5.763E-4 3.355E-4 6 170
6 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 1.843E-7 9.250E-5 7.943E-4 5.550E-4 8 469
7 M1162 STAT1 [GeneID=6772] targets in hematopoetic signaling. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.865E-7 1.095E-4 9.403E-4 8.629E-4 3 10
8 M5913 Genes up-regulated in response to IFNG [GeneID=3458]. MSigDB H: Hallmark Gene Sets (v6.0) 2.908E-7 1.095E-4 9.403E-4 8.759E-4 6 200
9 M14174 Genes down-regulated in K562 cells (bone marrow) after treatment with dasatinib [PubChem=3062316] or imatinib [PubChem=5291]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.808E-7 2.279E-4 1.957E-3 2.051E-3 3 13
10 M8804 Genes encoding the NF-kB core signaling proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.657E-7 2.608E-4 2.239E-3 2.608E-3 3 14
11 M1411 Genes up-regulated by UV-irradiation in cervical cancer cells after knockdown of CDKN2A [GeneID=1029]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.779E-7 2.678E-4 2.299E-3 2.945E-3 4 55
12 17369842-Table1 Human Cervical Lau07 60genes GeneSigDB 1.300E-6 3.263E-4 2.802E-3 3.915E-3 4 59
13 M4267 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 7.282E-6 8.530E-4 7.325E-3 2.193E-2 5 198
14 M4292 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 6 h versus cDCs infected with Newcastle disease virus (NDV) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 7.282E-6 8.530E-4 7.325E-3 2.193E-2 5 198
15 M9797 Genes up-regulated in B lymphocytes: naïve versus plasmablasts. MSigDB C7: Immunologic Signatures (v6.0) 7.462E-6 8.530E-4 7.325E-3 2.248E-2 5 199
16 M3296 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) 1 day after stimulation with YF17D vaccine versus PBMC 7 days after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 7.462E-6 8.530E-4 7.325E-3 2.248E-2 5 199
17 M3411 Genes down-regulated in comparison of microglia cells 1 h after stimulation with IFNG [GeneID=3458] versus microglia cells 6 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
18 M3288 Genes down-regulated in comparison of unstimulated peripheral blood mononuclear cells (PBMC) versus PBMC 7 days after stimulation with YF17D vaccine. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
19 M4460 Genes up-regulated in comparison of monocytes cultured for 0 days versus those cultured for 7 days. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
20 M8967 Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
21 M3142 Genes up-regulated in comparison of macrophages cultured with M-CSF [GeneID=1435] and IFNG [GeneID=3458] versus macrophages cultured with M-CSF [GeneID=1435] and Pam3Cyc. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
22 M4945 Genes up-regulated in comparison of monocytes versus plasmacytoid dendritic cells (pDC). MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
23 M3093 Genes down-regulated in comparison of healthy CD4 [GeneID=920] T cells versus systemic lupus erythematosus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
24 M4125 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 0.5 h versus those stimulated with CpG DNA (TLR9 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
25 M7740 Genes down-regulated in macrophages: wildtype versus NR3C2 [GeneID=4306] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
26 M8969 Genes down-regulated in CD4 [GeneID=920] over-expressing: FOXP3 [GeneID=50943] and PPARg2 form of PPARG [GeneID=5468] versus FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
27 M7177 Genes down-regulated in B lymphocytes from cord blood: naïve versus transitional CR2 [GeneID=1380]. MSigDB C7: Immunologic Signatures (v6.0) 7.646E-6 8.530E-4 7.325E-3 2.303E-2 5 200
28 15963930-Table1 Human StemCell Lam05 32genes GeneSigDB 8.569E-6 9.218E-4 7.916E-3 2.581E-2 3 29
29 15896717-Table4 Human Leukemia Bal05 07genes GeneSigDB 3.875E-5 4.025E-3 3.456E-2
1.167E-1
 2 7
30 16479007-Table3 Human StemCell Jaitin06 49genes GeneSigDB 4.240E-5 4.257E-3 3.656E-2
1.277E-1
 3 49
31 17804543-Table2 Human Leukemia Achiron07 55genes GeneSigDB 4.506E-5 4.379E-3 3.760E-2
1.357E-1
 3 50
32 16143142-Table4 Human Colon diPietro05 54genes GeneSigDB 4.784E-5 4.503E-3 3.867E-2
1.441E-1
 3 51
33 18366759-Table1 Human Liver Semeus08 65genes GeneSigDB 5.682E-5 5.186E-3 4.453E-2
1.711E-1
 3 54
34 M5902 Genes mediating programmed cell death (apoptosis) by activation of caspases. MSigDB H: Hallmark Gene Sets (v6.0) 6.977E-5 5.394E-3 4.632E-2
2.102E-1
 4 161
35 M6303 Genes encoding IkappaB kinase (IKK) interacting proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.041E-5 5.394E-3 4.632E-2
2.121E-1
 3 58
36 M6859 Genes down-regulated in spleens from mice immunized with ova peptides alone versus those immunized with monophosphoryl lipid A as adjuvant. MSigDB C7: Immunologic Signatures (v6.0) 7.147E-5 5.394E-3 4.632E-2
2.153E-1
 4 162
37 M12570 Genes down-regulated in T-PLL cells (T-cell prolymphocytic leukemia) bearing the inv(14)/t(14:14) chromosomal aberration. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.269E-5 5.394E-3 4.632E-2
2.189E-1
 5 320
38 M6846 Genes down-regulated in macrophages: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 8.041E-5 5.394E-3 4.632E-2
2.422E-1
 4 167
39 M6816 Genes down-regulated in immature dendritic cells: untreated versus interferon alpha. MSigDB C7: Immunologic Signatures (v6.0) 8.420E-5 5.394E-3 4.632E-2
2.536E-1
 4 169
40 M6808 Genes down-regulated in B lymphocytes treated by anti-HEL and expressing BCR [GeneID=613] fusions with: IgM versus IgMG. MSigDB C7: Immunologic Signatures (v6.0) 8.615E-5 5.394E-3 4.632E-2
2.595E-1
 4 170
41 M6818 Genes down-regulated in dendritic cells: untreated versus anti-FcgRIIB. MSigDB C7: Immunologic Signatures (v6.0) 8.813E-5 5.394E-3 4.632E-2
2.654E-1
 4 171
42 19096012-TableS3 Human Viral Chetaille09 425genes GeneSigDB 1.079E-4 5.394E-3 4.632E-2
3.249E-1
 5 348
43 15896717-Table8 Human Leukemia Bal05 12genes GeneSigDB 1.213E-4 5.394E-3 4.632E-2
3.652E-1
 2 12
44 16410819-Table4 Mouse Viral Stoff-Khalili06 15genes Unique GeneSigDB 1.432E-4 5.394E-3 4.632E-2
4.313E-1
 2 13
45 M4284 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 0 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h. MSigDB C7: Immunologic Signatures (v6.0) 1.434E-4 5.394E-3 4.632E-2
4.319E-1
 4 194
46 M6082 Genes down-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: TGFB1 and IL4 [GeneID=7040;3565] (2h) versus untreated (2h). MSigDB C7: Immunologic Signatures (v6.0) 1.491E-4 5.394E-3 4.632E-2
4.492E-1
 4 196
47 M9520 Genes up-regulated in CD8 T effectors at acute infection with LCMV-Armstrong: day 6 versus day 15. MSigDB C7: Immunologic Signatures (v6.0) 1.491E-4 5.394E-3 4.632E-2
4.492E-1
 4 196
48 M4296 Genes down-regulated in comparison of control conventional dendritic cells (cDC) at 18 h versus cDCs infected with Newcastle disease virus (NDV) at 18 h. MSigDB C7: Immunologic Signatures (v6.0) 1.491E-4 5.394E-3 4.632E-2
4.492E-1
 4 196
49 M4715 Genes down-regulated in comparison of dendritic cells (DC) stimulated with R848 at 2 h versus DCs stimulated with LPS (TLR4 agonist) and R848 for 2 h. MSigDB C7: Immunologic Signatures (v6.0) 1.521E-4 5.394E-3 4.632E-2
4.581E-1
 4 197
50 M7977 Genes up-regulated in bone marrow-derived macrophages with PPARG [GeneID=5468] knockout: control versus rosiglitazone [PubChem=77999]. MSigDB C7: Immunologic Signatures (v6.0) 1.521E-4 5.394E-3 4.632E-2
4.581E-1
 4 197
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 32 input genes in category / 1436 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM538248 500 Myeloid Cells, DC.4+.Sp, CD11b CD45 CD4 CD11c CD8a, Spleen, avg-1 Immgen.org, GSE15907 1.117E-6 6.138E-4 4.817E-3 1.605E-3 7 383
2 GSM605826 500 Myeloid Cells, DC.4+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-1 Immgen.org, GSE15907 1.117E-6 6.138E-4 4.817E-3 1.605E-3 7 383
3 GSM538249 500 Myeloid Cells, DC.4+.Sp, CD11b CD11c CD45 CD8a CD4, Spleen, avg-3 Immgen.org, GSE15907 1.282E-6 6.138E-4 4.817E-3 1.842E-3 7 391
4 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/2/1 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/2/1 TCGA-Testes 5.139E-6 1.845E-3 1.448E-2 7.379E-3 5 174
5 GSM538266 500 Myeloid Cells, DC.8-4-11b+.Sp, CD11b CD11c CD45 CD8a CD4, Spleen, avg-2 Immgen.org, GSE15907 1.557E-5 4.472E-3 3.509E-2 2.236E-2 6 376
6 Facebase RNAseq e10.5 Neural Epithelium Overlying Central Eminence 2500 K4 FacebaseRNAseq e10.5 Neural Epithelium Overlying Central Eminence top-relative-expression-ranked 2500 k-means-cluster#4 FaceBase_RNAseq 4.766E-5 1.141E-2
8.950E-2
6.843E-2
 6 459
7 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/4 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Mucinous Rectal Adenocarcinoma/5/4 TCGA-Colorectal 6.130E-5 1.258E-2
9.868E-2
8.803E-2
 4 147
8 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/1/1 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma/Epitheliod/1/1 TCGA-Mesothelium 9.300E-5 1.669E-2
1.310E-1
1.336E-1
 2 10
9 GSM538198 500 B cells, B.Fo.PC, IgD+ IgM+ CD19+ CD43- CD5- CD23+, Peritoneal Cavity, avg-3 Immgen.org, GSE15907 1.492E-4 2.380E-2
1.868E-1
2.142E-1
 5 352
10 Facebase RNAseq ratio e10.5 MandibularArch vs MaxillaryArch 2500 K1 FacebaseRNAseq ratio e10.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 2.262E-4 2.916E-2
2.289E-1
3.248E-1
 5 385
11 10X Human 68K PBMC CD14+ Monocyte Subtype CD14+ Monocyte-CD14+ Monocyte c4 Top 200 Genes 10X Human 68K PBMC CD14+ Monocyte Subtype CD14+ Monocyte-CD14+ Monocyte c4 Top 200 Genes 2.289E-4 2.916E-2
2.289E-1
3.288E-1
 5 386
12 GSM605868 500 Myeloid Cells, Mo.6C+II+.Bl, CD115+ B220- CD43+ Ly6C+ MHCIIint, Blood, avg-4 Immgen.org, GSE15907 2.957E-4 2.916E-2
2.289E-1
4.246E-1
 5 408
13 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 2.990E-4 2.916E-2
2.289E-1
4.294E-1
 5 409
14 GSM605872 500 Myeloid Cells, Mo.6C+II-.Bl, Cd115+ B220- CD43+ Ly6C+ MHCII-, Blood, avg-3 Immgen.org, GSE15907 3.058E-4 2.916E-2
2.289E-1
4.391E-1
 5 411
15 Facebase RNAseq ratio e10.5 MaxillaryArch vs Mandibular 2500 K3 FacebaseRNAseq ratio e10.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 2500 k-means-cluster#3 FaceBase_RNAseq 3.092E-4 2.916E-2
2.289E-1
4.441E-1
 5 412
16 Facebase RNAseq e9.5 Olfactory Placode 2500 K3 FacebaseRNAseq e9.5 Olfactory Placode top-relative-expression-ranked 2500 k-means-cluster#3 FaceBase_RNAseq 3.415E-4 2.916E-2
2.289E-1
4.904E-1
 5 421
17 Facebase RNAseq ratio e9.5 MandibularArch vs MaxillaryArch 2500 K1 FacebaseRNAseq ratio e9.5 MandibularArch vs MaxillaryArch top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 3.453E-4 2.916E-2
2.289E-1
4.958E-1
 5 422
18 Facebase RNAseq e10.5 Mandibular Arch 2500 K1 FacebaseRNAseq e10.5 Mandibular Arch top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 3.967E-4 3.165E-2
2.484E-1
5.697E-1
 5 435
19 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 2500 K1 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 4.585E-4 3.465E-2
2.719E-1
6.583E-1
 5 449
20 Facebase RNAseq ratio e9.5 MaxillaryArch vs Mandibular 2500 K1 FacebaseRNAseq ratio e9.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 5.324E-4 3.676E-2
2.885E-1
7.645E-1
 5 464
21 Facebase RNAseq e8.5 Paraxial Mesoderm 2500 K1 FacebaseRNAseq e8.5 Paraxial Mesoderm top-relative-expression-ranked 2500 k-means-cluster#1 FaceBase_RNAseq 5.376E-4 3.676E-2
2.885E-1
7.720E-1
 5 465
22 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/5/1 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Seminoma- NOS/5/1 TCGA-Testes 6.161E-4 4.022E-2
3.156E-1
8.847E-1
 3 114
Show 17 more annotations

15: Computational [Display Chart] 20 input genes in category / 108 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8373 GNF2 CD33 Neighborhood of CD33 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.481E-8 4.839E-6 2.547E-5 4.839E-6 5 52
2 M19427 GNF2 FOS Neighborhood of FOS MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.107E-6 5.980E-5 3.148E-4 1.196E-4 4 41
3 M1250 GNF2 MCL1 Neighborhood of MCL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.232E-6 1.524E-4 8.020E-4 4.571E-4 4 57
4 M7032 GNF2 CARD15 Neighborhood of CARD15 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.661E-6 2.609E-4 1.373E-3 1.043E-3 4 70
5 M4396 GNF2 CASP1 Neighborhood of CASP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.988E-5 1.293E-3 6.809E-3 6.467E-3 4 111
6 M12582 GNF2 CD1D Neighborhood of CD1D MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.103E-5 1.601E-3 8.426E-3 9.831E-3 3 45
7 M13076 GNF2 S100A4 Neighborhood of S100A4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.038E-4 1.601E-3 8.426E-3 1.121E-2 3 47
8 M17265 GNF2 PECAM1 Neighborhood of PECAM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.753E-4 2.367E-3 1.246E-2 1.894E-2 3 56
9 M356 GNF2 TNFRSF1B Neighborhood of TNFRSF1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.732E-4 3.278E-3 1.726E-2 2.950E-2 3 65
10 M14338 GNF2 HCK Neighborhood of HCK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.080E-4 8.726E-3 4.593E-2
8.726E-2
 3 94
11 M5798 GNF2 FGR Neighborhood of FGR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.805E-3 1.727E-2
9.093E-2
1.950E-1
 2 32
12 M4219 MODULE 300 Programmed cell death. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.919E-3 1.727E-2
9.093E-2
2.073E-1
 2 33
13 M14596 MORF PML Neighborhood of PML MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.811E-3 2.255E-2
1.187E-1
3.036E-1
 3 145
14 M3336 MORF LTK Neighborhood of LTK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.923E-3 2.255E-2
1.187E-1
3.157E-1
 3 147
15 M1953 GNF2 ITGB2 Neighborhood of ITGB2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.638E-3 4.059E-2
2.137E-1
6.089E-1
 2 57
16 M13614 GNF2 MYD88 Neighborhood of MYD88 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.230E-3 4.206E-2
2.214E-1
6.729E-1
 2 60
Show 11 more annotations

16: MicroRNA [Display Chart] 32 input genes in category / 472 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-200b-3p:Functional MTI Functional MTI miRTarbase 1.446E-6 5.953E-4 4.010E-3 6.825E-4 4 186
2 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 2.523E-6 5.953E-4 4.010E-3 1.191E-3 4 214
3 hsa-miR-429:Functional MTI Functional MTI miRTarbase 4.247E-5 6.682E-3 4.500E-2 2.004E-2 3 151
4 hsa-miR-566:mirSVR lowEffct hsa-miR-566:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.743E-4 4.417E-2
2.975E-1
1.767E-1
 3 316

17: Drug [Display Chart] 32 input genes in category / 9387 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000445779 YF-1 Stitch 4.919E-22 4.617E-18 4.490E-17 4.617E-18 12 83
2 CID005192834 AC1NQAAM Stitch 4.886E-17 2.293E-13 2.230E-12 4.586E-13 11 144
3 CID005195973 AC1NQGJV Stitch 4.787E-12 1.498E-8 1.456E-7 4.493E-8 7 68
4 CID000025500 nickel hydroxide Stitch 6.025E-11 1.414E-7 1.375E-6 5.656E-7 9 259
5 CID000445938 Nb d Stitch 8.684E-11 1.630E-7 1.585E-6 8.151E-7 8 174
6 ctd:C524042 3,5-bis(2-fluorobenzylidene)piperidin-4-one CTD 5.663E-10 8.860E-7 8.616E-6 5.316E-6 6 70
7 CID000213546 poly(I-C Stitch 3.350E-9 4.492E-6 4.368E-5 3.145E-5 7 171
8 ctd:C003898 2-anisidine CTD 4.704E-9 5.520E-6 5.368E-5 4.416E-5 6 99
9 ctd:C016340 o,p'-DDT CTD 8.527E-9 8.894E-6 8.649E-5 8.004E-5 9 455
10 ctd:D011067 Poly dA-dT CTD 9.981E-9 9.370E-6 9.111E-5 9.370E-5 3 4
11 CID002748618 M50054 Stitch 1.290E-8 1.101E-5 1.071E-4 1.211E-4 6 117
12 CID000440911 ent-kaurene Stitch 8.473E-8 6.628E-5 6.445E-4 7.954E-4 4 30
13 ctd:D005665 Furosemide CTD 1.081E-7 7.803E-5 7.588E-4 1.014E-3 6 167
14 ctd:C008435 methyldithiocarbamate CTD 1.179E-7 7.873E-5 7.656E-4 1.107E-3 5 85
15 CID000032744 polyinosinic-polycytidylic acid Stitch 1.299E-7 7.873E-5 7.656E-4 1.219E-3 7 291
16 ctd:D009550 Nigericin CTD 1.392E-7 7.873E-5 7.656E-4 1.307E-3 3 8
17 CID000004692 C15H20O3 Stitch 1.426E-7 7.873E-5 7.656E-4 1.338E-3 6 175
18 ctd:C549066 4-methyl-N1-(3-phenylpropyl)benzene-1,2-diamine CTD 1.611E-7 7.959E-5 7.739E-4 1.512E-3 4 35
19 ctd:D000872 Anthocyanins CTD 1.611E-7 7.959E-5 7.739E-4 1.512E-3 4 35
20 CID005351568 imidazoquinoline Stitch 2.802E-7 1.270E-4 1.235E-3 2.630E-3 5 101
21 ctd:D008276 Magnesium Hydroxide CTD 2.977E-7 1.270E-4 1.235E-3 2.795E-3 3 10
22 ctd:C523668 3-(5-(2,3-dichlorophenyl)-1H-tetrazol-1-yl)methylpyridine CTD 2.977E-7 1.270E-4 1.235E-3 2.795E-3 3 10
23 ctd:D037741 Fullerenes CTD 3.420E-7 1.396E-4 1.357E-3 3.210E-3 4 42
24 ctd:C455139 myrtucommulone A CTD 3.767E-7 1.414E-4 1.376E-3 3.536E-3 4 43
25 CID000163608 DEANO Stitch 3.767E-7 1.414E-4 1.376E-3 3.536E-3 4 43
26 ctd:D004875 Ergosterol CTD 5.448E-7 1.967E-4 1.913E-3 5.114E-3 3 12
27 CID000068352 alpha-methylene-gamma-butyrolactone Stitch 7.076E-7 2.372E-4 2.307E-3 6.642E-3 3 13
28 CID000032741 poly r(A-U Stitch 7.076E-7 2.372E-4 2.307E-3 6.642E-3 3 13
29 ctd:C031238 zinc sulfide CTD 7.569E-7 2.450E-4 2.382E-3 7.105E-3 4 51
30 CID000013588 cyclopentenone Stitch 8.429E-7 2.637E-4 2.565E-3 7.912E-3 5 126
31 CID000001433 1400 W Stitch 1.368E-6 4.053E-4 3.941E-3 1.284E-2 4 59
32 ctd:C413879 EKB 569 CTD 1.382E-6 4.053E-4 3.941E-3 1.297E-2 3 16
33 CID000005154 sanguinarine Stitch 1.464E-6 4.164E-4 4.049E-3 1.374E-2 4 60
34 ctd:C433788 lipopolysaccharide, E. coli O26-B6 CTD 1.687E-6 4.659E-4 4.530E-3 1.584E-2 5 145
35 CID000449297 AC1L9MYN Stitch 2.009E-6 5.389E-4 5.240E-3 1.886E-2 3 18
36 ctd:D000493 Allopurinol CTD 2.151E-6 5.609E-4 5.454E-3 2.019E-2 4 66
37 CID000104930 trimethylarsine oxide Stitch 2.384E-6 5.992E-4 5.827E-3 2.238E-2 3 19
38 CID000004489 NSC292567 Stitch 2.426E-6 5.992E-4 5.827E-3 2.277E-2 4 68
39 CID000159822 AC1L4MJU Stitch 2.624E-6 6.315E-4 6.141E-3 2.463E-2 6 288
40 1297 UP Suloctidil [54063-56-8]; Up 200; 11.8uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.823E-6 6.625E-4 6.442E-3 2.650E-2 5 161
41 CID000014888 arsenic trioxide Stitch 3.131E-6 7.169E-4 6.971E-3 2.939E-2 7 468
42 CID000009824 N-tosyl-L-phenylalanine chloromethyl ketone Stitch 3.279E-6 7.329E-4 7.127E-3 3.078E-2 5 166
43 ctd:C555916 MitoTEMPO CTD 3.778E-6 8.246E-4 8.019E-3 3.546E-2 3 22
44 CID000065351 APDC Stitch 4.640E-6 9.712E-4 9.444E-3 4.355E-2 6 318
45 CID000004518 DETA/NO Stitch 4.656E-6 9.712E-4 9.444E-3 4.370E-2 4 80
46 CID000004551 28 N Stitch 4.955E-6 9.897E-4 9.624E-3 4.652E-2 3 24
47 CID000122001 FK-156 Stitch 4.955E-6 9.897E-4 9.624E-3 4.652E-2 3 24
48 ctd:D008555 Melitten CTD 5.394E-6 1.055E-3 1.026E-2
5.063E-2
 4 83
49 CID000000338 salicylate Stitch 5.541E-6 1.061E-3 1.032E-2
5.201E-2
 6 328
50 ctd:C570894 2,6-diaminopyridine-3,5-bis(thiocyanate) CTD 5.700E-6 1.070E-3 1.041E-2
5.350E-2
 2 3
Show 45 more annotations

18: Disease [Display Chart] 32 input genes in category / 945 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1319860 Sendai virus infection DisGeNET BeFree 4.092E-9 1.951E-6 1.449E-5 3.867E-6 4 11
2 C0004943 Behcet Syndrome DisGeNET Curated 5.605E-9 1.951E-6 1.449E-5 5.297E-6 8 210
3 C1850900 Familial primary gastric lymphoma DisGeNET Curated 6.603E-9 1.951E-6 1.449E-5 6.240E-6 6 75
4 C0041234 Chagas Disease DisGeNET BeFree 8.259E-9 1.951E-6 1.449E-5 7.805E-6 7 139
5 C0242647 Mucosa-Associated Lymphoid Tissue Lymphoma DisGeNET Curated 3.914E-8 7.397E-6 5.495E-5 3.699E-5 7 174
6 C0281773 acute glaucoma DisGeNET BeFree 1.393E-7 1.961E-5 1.457E-4 1.317E-4 3 6
7 C3860213 Autoinflammatory disorder DisGeNET BeFree 1.538E-7 1.961E-5 1.457E-4 1.454E-4 4 25
8 C0349532 Gastric lymphoma DisGeNET Curated 1.816E-7 1.961E-5 1.457E-4 1.716E-4 4 26
9 C0751967 Multiple Sclerosis, Relapsing-Remitting DisGeNET Curated 2.066E-7 1.961E-5 1.457E-4 1.953E-4 5 68
10 C0014038 Encephalitis DisGeNET Curated 2.075E-7 1.961E-5 1.457E-4 1.961E-4 6 133
11 C0375023 Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 3.931E-7 3.377E-5 2.509E-4 3.715E-4 7 244
12 C0494261 Combined immunodeficiency DisGeNET Curated 4.331E-7 3.411E-5 2.534E-4 4.093E-4 4 32
13 C0004623 Bacterial Infections DisGeNET Curated 5.726E-7 4.163E-5 3.092E-4 5.411E-4 7 258
14 C0343068 Familial cold urticaria DisGeNET Curated 1.520E-6 1.026E-4 7.624E-4 1.437E-3 3 12
15 C0342731 Deficiency of mevalonate kinase DisGeNET Curated 1.974E-6 1.094E-4 8.124E-4 1.865E-3 3 13
16 C3890737 Autoinflammatory Syndrome DisGeNET BeFree 1.974E-6 1.094E-4 8.124E-4 1.865E-3 3 13
17 C0374997 Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site DisGeNET BeFree 2.041E-6 1.094E-4 8.124E-4 1.929E-3 7 312
18 C0175697 Van der Woude syndrome DisGeNET Curated 2.083E-6 1.094E-4 8.124E-4 1.968E-3 6 197
19 C0031069 Familial Mediterranean Fever DisGeNET Curated 2.493E-6 1.176E-4 8.737E-4 2.355E-3 4 49
20 C1861303 SYNOVITIS, GRANULOMATOUS, WITH UVEITIS AND CRANIAL NEUROPATHIES (disorder) DisGeNET Curated 2.509E-6 1.176E-4 8.737E-4 2.371E-3 3 14
21 C0035235 Respiratory Syncytial Virus Infections DisGeNET Curated 2.614E-6 1.176E-4 8.737E-4 2.470E-3 5 113
22 C4225427 SINGLETON-MERTEN SYNDROME 1 DisGeNET Curated 3.778E-6 1.552E-4 1.153E-3 3.570E-3 2 2
23 C3272822 Colorectal Lymphoma DisGeNET BeFree 3.778E-6 1.552E-4 1.153E-3 3.570E-3 2 2
24 C2316212 Cryopyrin-Associated Periodic Syndromes DisGeNET Curated 5.594E-6 2.033E-4 1.510E-3 5.286E-3 3 18
25 C1865868 ALZHEIMER DISEASE 5 DisGeNET Curated 5.594E-6 2.033E-4 1.510E-3 5.286E-3 3 18
26 C0235896 Infiltrate of lung DisGeNET Curated 5.594E-6 2.033E-4 1.510E-3 5.286E-3 3 18
27 C1704383 Primary Lung Lymphoma DisGeNET BeFree 1.132E-5 3.572E-4 2.654E-3 1.070E-2 2 3
28 C0006035 Borrelia Infections DisGeNET BeFree 1.132E-5 3.572E-4 2.654E-3 1.070E-2 2 3
29 C0268390 Muckle-Wells Syndrome DisGeNET Curated 1.206E-5 3.572E-4 2.654E-3 1.140E-2 3 23
30 C0025229 Melioidosis DisGeNET BeFree 1.206E-5 3.572E-4 2.654E-3 1.140E-2 3 23
31 C0409818 Chronic Infantile Neurological, Cutaneous, and Articular Syndrome DisGeNET Curated 1.206E-5 3.572E-4 2.654E-3 1.140E-2 3 23
32 C1367654 Marginal Zone B-Cell Lymphoma DisGeNET BeFree 1.239E-5 3.572E-4 2.654E-3 1.171E-2 4 73
33 C0011615 Dermatitis, Atopic DisGeNET Curated 1.247E-5 3.572E-4 2.654E-3 1.179E-2 7 411
34 C0025295 Meningitis, Pneumococcal DisGeNET BeFree 1.763E-5 4.901E-4 3.641E-3 1.666E-2 3 26
35 C0854135 Pseudomonas aeruginosa infection DisGeNET BeFree 1.981E-5 5.349E-4 3.974E-3 1.872E-2 3 27
36 C0850666 helicobacter pylori infection DisGeNET BeFree 2.884E-5 7.571E-4 5.624E-3 2.726E-2 6 312
37 C1290884 Inflammatory disorder DisGeNET BeFree 3.033E-5 7.746E-4 5.754E-3 2.866E-2 5 187
38 C0032285 Pneumonia DisGeNET Curated 3.212E-5 7.988E-4 5.934E-3 3.035E-2 7 476
39 C0750103 vaginalis DisGeNET BeFree 3.764E-5 9.120E-4 6.775E-3 3.557E-2 2 5
40 C1333782 Gastric Mucosa-Associated Lymphoid Tissue Lymphoma DisGeNET BeFree 4.385E-5 1.036E-3 7.697E-3 4.144E-2 3 35
41 C1275321 Primary cutaneous marginal zone B-cell lymphoma DisGeNET BeFree 5.639E-5 1.269E-3 9.425E-3
5.329E-2
 2 6
42 C3889979 Periodic Fever Syndrome DisGeNET BeFree 5.639E-5 1.269E-3 9.425E-3
5.329E-2
 2 6
43 C0740372 Gastrointestinal lymphoma DisGeNET BeFree 7.885E-5 1.693E-3 1.258E-2
7.451E-2
 2 7
44 C0679408 Lesion of stomach DisGeNET BeFree 7.885E-5 1.693E-3 1.258E-2
7.451E-2
 2 7
45 C0566602 Primary sclerosing cholangitis DisGeNET Curated 1.125E-4 2.311E-3 1.717E-2
1.063E-1
 4 128
46 C0023343 Leprosy DisGeNET Curated 1.125E-4 2.311E-3 1.717E-2
1.063E-1
 4 128
47 C0026946 Mycoses DisGeNET BeFree 1.180E-4 2.373E-3 1.763E-2
1.115E-1
 5 249
48 C1290886 Chronic inflammatory disorder DisGeNET BeFree 1.212E-4 2.373E-3 1.763E-2
1.145E-1
 3 49
49 C0266999 Vesicular Stomatitis DisGeNET Curated 1.231E-4 2.373E-3 1.763E-2
1.163E-1
 4 131
50 C3539909 Allergic disposition DisGeNET BeFree 1.344E-4 2.450E-3 1.820E-2
1.270E-1
 5 256
Show 45 more annotations