Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc117_21, positive side

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1: GO: Molecular Function [Display Chart] 21 input genes in category / 62 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008307 structural constituent of muscle 1.339E-19 8.304E-18 3.913E-17 8.304E-18 9 41
2 GO:0003779 actin binding 7.012E-12 2.174E-10 1.024E-9 4.347E-10 10 412
3 GO:0005200 structural constituent of cytoskeleton 2.214E-11 4.575E-10 2.156E-9 1.373E-9 7 110
4 GO:0051371 muscle alpha-actinin binding 1.488E-10 2.306E-9 1.087E-8 9.223E-9 4 9
5 GO:0051015 actin filament binding 5.557E-9 6.891E-8 3.247E-7 3.445E-7 6 132
6 GO:0051393 alpha-actinin binding 1.476E-8 1.525E-7 7.188E-7 9.152E-7 4 25
7 GO:0042805 actinin binding 6.819E-8 6.039E-7 2.846E-6 4.227E-6 4 36
8 GO:0031432 titin binding 4.435E-7 3.437E-6 1.620E-5 2.750E-5 3 14
9 GO:0051373 FATZ binding 3.616E-6 2.491E-5 1.174E-4 2.242E-4 2 3
10 GO:0030374 nuclear receptor transcription coactivator activity 2.936E-5 1.820E-4 8.578E-4 1.820E-3 3 54
11 GO:0017166 vinculin binding 7.907E-5 4.457E-4 2.100E-3 4.902E-3 2 12
12 GO:0005178 integrin binding 3.248E-4 1.658E-3 7.812E-3 2.013E-2 3 121
13 GO:0003713 transcription coactivator activity 3.576E-4 1.658E-3 7.812E-3 2.217E-2 4 310
14 GO:0044325 ion channel binding 3.743E-4 1.658E-3 7.812E-3 2.321E-2 3 127
15 GO:0030674 protein binding, bridging 7.751E-4 3.204E-3 1.510E-2 4.806E-2 3 163
16 GO:0060090 molecular adaptor activity 1.050E-3 4.067E-3 1.917E-2
6.507E-2
 3 181
17 GO:0050839 cell adhesion molecule binding 1.565E-3 5.709E-3 2.690E-2
9.705E-2
 3 208
18 GO:0070080 titin Z domain binding 2.249E-3 7.748E-3 3.651E-2
1.395E-1
 1 2
19 GO:0031014 troponin T binding 4.494E-3 1.467E-2
6.911E-2
2.786E-1
 1 4
20 GO:0031013 troponin I binding 5.615E-3 1.582E-2
7.456E-2
3.481E-1
 1 5
21 GO:0031433 telethonin binding 5.615E-3 1.582E-2
7.456E-2
3.481E-1
 1 5
22 GO:0030375 thyroid hormone receptor coactivator activity 5.615E-3 1.582E-2
7.456E-2
3.481E-1
 1 5
23 GO:0030274 LIM domain binding 8.969E-3 2.317E-2
1.092E-1
5.561E-1
 1 8
24 GO:0097493 structural molecule activity conferring elasticity 8.969E-3 2.317E-2
1.092E-1
5.561E-1
 1 8
25 GO:0043495 protein membrane anchor 1.008E-2 2.501E-2
1.179E-1
6.253E-1
 1 9
26 GO:0005523 tropomyosin binding 1.565E-2 3.731E-2
1.758E-1
9.700E-1
 1 14
27 GO:0019215 intermediate filament binding 1.786E-2 3.819E-2
1.799E-1
1.000E0
 1 16
28 GO:0008093 cytoskeletal adaptor activity 1.786E-2 3.819E-2
1.799E-1
1.000E0
 1 16
29 GO:0031005 filamin binding 1.786E-2 3.819E-2
1.799E-1
1.000E0
 1 16
30 GO:0005516 calmodulin binding 1.907E-2 3.941E-2
1.857E-1
1.000E0
 2 190
31 GO:0030506 ankyrin binding 2.338E-2 4.676E-2
2.204E-1
1.000E0
 1 21
Show 26 more annotations

2: GO: Biological Process [Display Chart] 21 input genes in category / 442 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030239 myofibril assembly 6.164E-23 2.725E-20 1.817E-19 2.725E-20 11 61
2 GO:0055002 striated muscle cell development 4.610E-20 1.019E-17 6.795E-17 2.038E-17 12 166
3 GO:0055001 muscle cell development 1.338E-19 1.972E-17 1.315E-16 5.916E-17 12 181
4 GO:0031032 actomyosin structure organization 5.008E-18 5.534E-16 3.691E-15 2.214E-15 11 162
5 GO:0051146 striated muscle cell differentiation 4.031E-17 3.154E-15 2.104E-14 1.782E-14 12 289
6 GO:0045214 sarcomere organization 4.282E-17 3.154E-15 2.104E-14 1.893E-14 8 40
7 GO:0042692 muscle cell differentiation 2.880E-15 1.819E-13 1.213E-12 1.273E-12 12 412
8 GO:0030049 muscle filament sliding 1.378E-14 7.437E-13 4.960E-12 6.090E-12 7 40
9 GO:0033275 actin-myosin filament sliding 1.660E-14 7.437E-13 4.960E-12 7.339E-12 7 41
10 GO:0010927 cellular component assembly involved in morphogenesis 1.683E-14 7.437E-13 4.960E-12 7.437E-12 11 336
11 GO:0030048 actin filament-based movement 6.211E-13 2.496E-11 1.665E-10 2.745E-10 8 125
12 GO:0003012 muscle system process 1.091E-11 4.019E-10 2.681E-9 4.823E-9 10 430
13 GO:0070252 actin-mediated cell contraction 1.310E-11 4.454E-10 2.971E-9 5.790E-9 7 102
14 GO:0006936 muscle contraction 6.046E-11 1.909E-9 1.273E-8 2.672E-8 9 348
15 GO:0007015 actin filament organization 2.110E-9 6.218E-8 4.147E-7 9.327E-7 8 345
16 GO:0048738 cardiac muscle tissue development 2.513E-9 6.942E-8 4.630E-7 1.111E-6 7 215
17 GO:0014706 striated muscle tissue development 6.347E-9 1.650E-7 1.101E-6 2.805E-6 8 397
18 GO:0060537 muscle tissue development 8.975E-9 2.204E-7 1.470E-6 3.967E-6 8 415
19 GO:0007517 muscle organ development 1.952E-7 4.542E-6 3.029E-5 8.630E-5 7 405
20 GO:0055008 cardiac muscle tissue morphogenesis 6.815E-7 1.506E-5 1.005E-4 3.012E-4 4 63
21 GO:0060415 muscle tissue morphogenesis 1.236E-6 2.602E-5 1.735E-4 5.464E-4 4 73
22 GO:0055013 cardiac muscle cell development 1.306E-6 2.624E-5 1.750E-4 5.772E-4 4 74
23 GO:0055006 cardiac cell development 1.614E-6 3.102E-5 2.069E-4 7.135E-4 4 78
24 GO:0048644 muscle organ morphogenesis 1.879E-6 3.460E-5 2.308E-4 8.304E-4 4 81
25 GO:0002576 platelet degranulation 5.718E-6 1.011E-4 6.742E-4 2.527E-3 4 107
26 GO:0055007 cardiac muscle cell differentiation 8.154E-6 1.386E-4 9.245E-4 3.604E-3 4 117
27 GO:0030240 skeletal muscle thin filament assembly 1.209E-5 1.979E-4 1.320E-3 5.342E-3 2 5
28 GO:0035051 cardiocyte differentiation 1.904E-5 3.005E-4 2.004E-3 8.414E-3 4 145
29 GO:0006941 striated muscle contraction 2.872E-5 4.377E-4 2.919E-3 1.269E-2 4 161
30 GO:0014866 skeletal myofibril assembly 3.377E-5 4.976E-4 3.319E-3 1.493E-2 2 8
31 GO:0055003 cardiac myofibril assembly 1.630E-4 2.258E-3 1.506E-2
7.206E-2
 2 17
32 GO:0003007 heart morphogenesis 1.635E-4 2.258E-3 1.506E-2
7.225E-2
 4 252
33 GO:0051271 negative regulation of cellular component movement 2.069E-4 2.772E-3 1.849E-2
9.147E-2
 4 268
34 GO:0060047 heart contraction 2.316E-4 3.010E-3 2.008E-2
1.024E-1
 4 276
35 GO:0003015 heart process 2.413E-4 3.048E-3 2.033E-2
1.067E-1
 4 279
36 GO:0035994 response to muscle stretch 2.760E-4 3.388E-3 2.260E-2
1.220E-1
 2 22
37 GO:0060048 cardiac muscle contraction 3.347E-4 3.998E-3 2.667E-2
1.479E-1
 3 122
38 GO:0045055 regulated exocytosis 3.829E-4 4.453E-3 2.970E-2
1.692E-1
 4 315
39 GO:0043501 skeletal muscle adaptation 4.179E-4 4.736E-3 3.159E-2
1.847E-1
 2 27
40 GO:0051017 actin filament bundle assembly 4.406E-4 4.869E-3 3.247E-2
1.948E-1
 3 134
41 GO:0061572 actin filament bundle organization 4.802E-4 5.177E-3 3.453E-2
2.122E-1
 3 138
42 GO:0032970 regulation of actin filament-based process 5.223E-4 5.497E-3 3.666E-2
2.309E-1
 4 342
43 GO:0003009 skeletal muscle contraction 1.064E-3 1.054E-2
7.032E-2
4.701E-1
 2 43
44 GO:1902396 protein localization to bicellular tight junction 1.128E-3 1.054E-2
7.032E-2
4.984E-1
 1 1
45 GO:0043056 forward locomotion 1.128E-3 1.054E-2
7.032E-2
4.984E-1
 1 1
46 GO:0071691 cardiac muscle thin filament assembly 1.128E-3 1.054E-2
7.032E-2
4.984E-1
 1 1
47 GO:0003065 positive regulation of heart rate by epinephrine 1.128E-3 1.054E-2
7.032E-2
4.984E-1
 1 1
48 GO:0045104 intermediate filament cytoskeleton organization 1.164E-3 1.054E-2
7.032E-2
5.147E-1
 2 45
49 GO:0031529 ruffle organization 1.217E-3 1.054E-2
7.032E-2
5.377E-1
 2 46
50 GO:0045103 intermediate filament-based process 1.217E-3 1.054E-2
7.032E-2
5.377E-1
 2 46
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 21 input genes in category / 84 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030017 sarcomere 1.167E-33 9.802E-32 4.915E-31 9.802E-32 18 198
2 GO:0044449 contractile fiber part 5.470E-33 2.297E-31 1.152E-30 4.595E-31 18 215
3 GO:0030016 myofibril 8.410E-33 2.355E-31 1.181E-30 7.064E-31 18 220
4 GO:0043292 contractile fiber 2.662E-32 5.590E-31 2.803E-30 2.236E-30 18 234
5 GO:0031674 I band 4.458E-26 7.489E-25 3.755E-24 3.744E-24 14 135
6 GO:0030018 Z disc 2.174E-24 3.044E-23 1.526E-22 1.827E-22 13 119
7 GO:0036379 myofilament 1.448E-18 1.738E-17 8.712E-17 1.216E-16 8 28
8 GO:0015629 actin cytoskeleton 3.010E-18 3.161E-17 1.585E-16 2.529E-16 14 476
9 GO:0005865 striated muscle thin filament 1.084E-13 1.012E-12 5.073E-12 9.106E-12 6 24
10 GO:0031143 pseudopodium 5.958E-12 5.005E-11 2.509E-10 5.005E-10 5 17
11 GO:0001725 stress fiber 7.808E-11 5.465E-10 2.740E-9 6.559E-9 6 67
12 GO:0097517 contractile actin filament bundle 7.808E-11 5.465E-10 2.740E-9 6.559E-9 6 67
13 GO:0032432 actin filament bundle 1.326E-10 8.571E-10 4.297E-9 1.114E-8 6 73
14 GO:0042641 actomyosin 1.842E-10 1.105E-9 5.543E-9 1.548E-8 6 77
15 GO:0005884 actin filament 5.008E-8 2.804E-7 1.406E-6 4.206E-6 5 94
16 GO:0005912 adherens junction 5.566E-7 2.922E-6 1.465E-5 4.676E-5 7 484
17 GO:0005859 muscle myosin complex 1.298E-6 6.414E-6 3.216E-5 1.090E-4 3 20
18 GO:0031430 M band 2.012E-6 9.391E-6 4.709E-5 1.690E-4 3 23
19 GO:0016460 myosin II complex 3.314E-6 1.465E-5 7.347E-5 2.784E-4 3 27
20 GO:0005863 striated muscle myosin thick filament 6.927E-6 2.909E-5 1.459E-4 5.819E-4 2 4
21 GO:0031672 A band 1.383E-5 5.530E-5 2.773E-4 1.161E-3 3 43
22 GO:0031093 platelet alpha granule lumen 2.914E-5 1.113E-4 5.579E-4 2.448E-3 3 55
23 GO:0031252 cell leading edge 5.362E-5 1.891E-4 9.483E-4 4.504E-3 5 389
24 GO:0016459 myosin complex 5.516E-5 1.891E-4 9.483E-4 4.633E-3 3 68
25 GO:0005925 focal adhesion 5.629E-5 1.891E-4 9.483E-4 4.728E-3 5 393
26 GO:0005924 cell-substrate adherens junction 5.977E-5 1.931E-4 9.682E-4 5.020E-3 5 398
27 GO:0030055 cell-substrate junction 6.341E-5 1.973E-4 9.892E-4 5.327E-3 5 403
28 GO:0031091 platelet alpha granule 7.395E-5 2.219E-4 1.112E-3 6.212E-3 3 75
29 GO:0005916 fascia adherens 8.952E-5 2.593E-4 1.300E-3 7.519E-3 2 13
30 GO:0034774 secretory granule lumen 1.074E-4 3.007E-4 1.508E-3 9.022E-3 3 85
31 GO:0030863 cortical cytoskeleton 1.590E-4 4.308E-4 2.160E-3 1.335E-2 3 97
32 GO:0030175 filopodium 1.845E-4 4.843E-4 2.428E-3 1.550E-2 3 102
33 GO:0060205 cytoplasmic vesicle lumen 1.954E-4 4.973E-4 2.494E-3 1.641E-2 3 104
34 GO:0031983 vesicle lumen 2.184E-4 5.396E-4 2.706E-3 1.835E-2 3 108
35 GO:0032982 myosin filament 2.884E-4 6.922E-4 3.471E-3 2.423E-2 2 23
36 GO:0044448 cell cortex part 4.488E-4 1.047E-3 5.251E-3 3.770E-2 3 138
37 GO:0001726 ruffle 8.097E-4 1.838E-3 9.217E-3
6.802E-2
 3 169
38 GO:0030027 lamellipodium 1.068E-3 2.362E-3 1.184E-2
8.974E-2
 3 186
39 GO:0098858 actin-based cell projection 1.394E-3 3.002E-3 1.505E-2
1.171E-1
 3 204
40 GO:0014704 intercalated disc 1.841E-3 3.867E-3 1.939E-2
1.547E-1
 2 58
41 GO:0060053 neurofilament cytoskeleton 2.202E-3 4.512E-3 2.262E-2
1.850E-1
 1 2
42 GO:0005913 cell-cell adherens junction 2.521E-3 4.924E-3 2.469E-2
2.117E-1
 2 68
43 GO:0030864 cortical actin cytoskeleton 2.521E-3 4.924E-3 2.469E-2
2.117E-1
 2 68
44 GO:0044291 cell-cell contact zone 2.744E-3 5.239E-3 2.627E-2
2.305E-1
 2 71
45 GO:0005938 cell cortex 2.967E-3 5.539E-3 2.777E-2
2.492E-1
 3 266
46 GO:0032127 dense core granule membrane 3.302E-3 6.029E-3 3.023E-2
2.773E-1
 1 3
47 GO:0005862 muscle thin filament tropomyosin 4.400E-3 7.864E-3 3.943E-2
3.696E-1
 1 4
48 GO:0099568 cytoplasmic region 5.201E-3 9.103E-3 4.564E-2
4.369E-1
 3 325
49 GO:0045098 type III intermediate filament 5.497E-3 9.424E-3 4.725E-2
4.618E-1
 1 5
50 GO:0005903 brush border 8.774E-3 1.419E-2
7.113E-2
7.370E-1
 2 129
Show 45 more annotations

4: Human Phenotype [Display Chart] 14 input genes in category / 710 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0100578 Lipoatrophy 8.819E-12 3.291E-9 2.351E-8 6.261E-9 8 76
2 HP:0003457 EMG abnormality 9.271E-12 3.291E-9 2.351E-8 6.582E-9 10 193
3 HP:0010876 Abnormality of circulating protein level 2.729E-11 6.459E-9 4.614E-8 1.938E-8 12 437
4 HP:0009125 Lipodystrophy 6.598E-11 7.717E-9 5.513E-8 4.684E-8 8 97
5 HP:0003236 Elevated serum creatine phosphokinase 6.993E-11 7.717E-9 5.513E-8 4.965E-8 10 236
6 HP:0040081 Abnormal levels of creatine kinase in blood 6.993E-11 7.717E-9 5.513E-8 4.965E-8 10 236
7 HP:0011021 Abnormality of circulating enzyme level 7.609E-11 7.717E-9 5.513E-8 5.402E-8 10 238
8 HP:0030682 Left ventricular noncompaction 1.416E-10 1.005E-8 7.180E-8 1.005E-7 6 31
9 HP:0030681 Abnormal morphology of myocardial trabeculae 1.416E-10 1.005E-8 7.180E-8 1.005E-7 6 31
10 HP:0031192 Abnormal morphology of left ventricular trabeculae 1.416E-10 1.005E-8 7.180E-8 1.005E-7 6 31
11 HP:0001644 Dilated cardiomyopathy 2.438E-10 1.573E-8 1.124E-7 1.731E-7 9 180
12 HP:0003198 Myopathy 1.124E-9 6.651E-8 4.751E-7 7.982E-7 10 312
13 HP:0000982 Palmoplantar keratoderma 1.297E-9 7.083E-8 5.059E-7 9.208E-7 8 140
14 HP:0009124 Abnormal adipose tissue morphology 5.265E-8 2.670E-6 1.907E-5 3.738E-5 8 223
15 HP:0000962 Hyperkeratosis 1.174E-7 5.556E-6 3.969E-5 8.334E-5 8 247
16 HP:0001035 Abnormality of keratinization 1.373E-7 6.092E-6 4.352E-5 9.748E-5 8 252
17 HP:0001635 Congestive heart failure 1.848E-7 7.720E-6 5.514E-5 1.312E-4 9 380
18 HP:0003458 EMG: myopathic abnormalities 2.274E-7 8.969E-6 6.407E-5 1.614E-4 5 51
19 HP:0001911 Abnormal granulocyte morphology 1.875E-6 7.005E-5 5.004E-4 1.331E-3 9 497
20 HP:0003722 Neck flexor weakness 2.484E-6 8.818E-5 6.299E-4 1.764E-3 3 10
21 HP:0001874 Abnormality of neutrophils 4.062E-6 1.359E-4 9.709E-4 2.884E-3 8 391
22 HP:0000467 Neck muscle weakness 4.212E-6 1.359E-4 9.709E-4 2.990E-3 4 40
23 HP:0011368 Epidermal thickening 4.473E-6 1.381E-4 9.864E-4 3.176E-3 8 396
24 HP:0003555 Muscle fiber splitting 7.482E-6 2.213E-4 1.581E-3 5.312E-3 3 14
25 HP:0001665 Abnormality of cardiac conduction 8.293E-6 2.326E-4 1.661E-3 5.888E-3 7 295
26 HP:0003691 Scapular winging 8.845E-6 2.326E-4 1.661E-3 6.280E-3 4 48
27 HP:0003391 Gowers sign 8.845E-6 2.326E-4 1.661E-3 6.280E-3 4 48
28 HP:0004971 Pulmonary artery hypoplasia 9.336E-6 2.367E-4 1.691E-3 6.629E-3 3 15
29 HP:0003701 Proximal muscle weakness 1.462E-5 3.497E-4 2.498E-3 1.038E-2 6 206
30 HP:0001072 Thickened skin 1.478E-5 3.497E-4 2.498E-3 1.049E-2 8 464
31 HP:0030319 Weakness of facial musculature 1.870E-5 4.024E-4 2.874E-3 1.328E-2 6 215
32 HP:0010827 Abnormality of the seventh cranial nerve 1.870E-5 4.024E-4 2.874E-3 1.328E-2 6 215
33 HP:0010628 Facial palsy 1.870E-5 4.024E-4 2.874E-3 1.328E-2 6 215
34 HP:0002515 Waddling gait 2.172E-5 4.535E-4 3.239E-3 1.542E-2 4 60
35 HP:0004308 Ventricular arrhythmia 2.532E-5 5.135E-4 3.668E-3 1.797E-2 5 131
36 HP:0001435 Abnormality of the shoulder girdle musculature 4.014E-5 7.916E-4 5.655E-3 2.850E-2 4 70
37 HP:0011006 Abnormality of the musculature of the neck 4.740E-5 9.097E-4 6.498E-3 3.366E-2 4 73
38 HP:0003810 Late-onset distal muscle weakness 4.913E-5 9.172E-4 6.552E-3 3.488E-2 2 4
39 HP:0002460 Distal muscle weakness 5.038E-5 9.172E-4 6.552E-3 3.577E-2 5 151
40 HP:0011675 Arrhythmia 5.402E-5 9.588E-4 6.849E-3 3.835E-2 7 392
41 HP:0003445 EMG: neuropathic changes 5.876E-5 1.018E-3 7.269E-3 4.172E-2 3 27
42 HP:0030956 Abnormality of cardiovascular system electrophysiology 6.466E-5 1.093E-3 7.808E-3 4.591E-2 7 403
43 HP:0000301 Abnormality of facial musculature 6.847E-5 1.131E-3 8.076E-3 4.862E-2 6 270
44 HP:0006824 Cranial nerve paralysis 9.847E-5 1.589E-3 1.135E-2
6.991E-2
 6 288
45 HP:0003736 Autophagic vacuoles 1.224E-4 1.902E-3 1.359E-2
8.691E-2
 2 6
46 HP:0004303 Abnormality of muscle fibers 1.232E-4 1.902E-3 1.359E-2
8.750E-2
 5 182
47 HP:0000782 Abnormality of the scapula 1.391E-4 2.101E-3 1.501E-2
9.875E-2
 4 96
48 HP:0001702 Abnormal tricuspid valve morphology 1.568E-4 2.319E-3 1.657E-2
1.113E-1
 4 99
49 HP:0001446 Abnormality of the musculature of the upper limbs 1.829E-4 2.650E-3 1.893E-2
1.299E-1
 4 103
50 HP:0001291 Abnormal cranial nerve morphology 2.402E-4 3.291E-3 2.351E-2
1.705E-1
 6 338
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 15 input genes in category / 466 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004087 abnormal muscle fiber morphology 6.544E-11 3.049E-8 2.050E-7 3.049E-8 10 459
2 MP:0004090 abnormal sarcomere morphology 1.207E-9 2.659E-7 1.787E-6 5.624E-7 6 85
3 MP:0010240 decreased skeletal muscle size 1.712E-9 2.659E-7 1.787E-6 7.976E-7 6 90
4 MP:0009400 decreased skeletal muscle fiber size 3.893E-9 3.398E-7 2.284E-6 1.814E-6 6 103
5 MP:0000759 abnormal skeletal muscle morphology 4.069E-9 3.398E-7 2.284E-6 1.896E-6 9 487
6 MP:0009458 abnormal skeletal muscle size 4.375E-9 3.398E-7 2.284E-6 2.039E-6 6 105
7 MP:0003084 abnormal skeletal muscle fiber morphology 1.121E-8 7.464E-7 5.018E-6 5.225E-6 7 224
8 MP:0004819 decreased skeletal muscle mass 2.821E-8 1.643E-6 1.105E-5 1.315E-5 6 143
9 MP:0009398 abnormal skeletal muscle fiber size 4.398E-8 2.277E-6 1.531E-5 2.050E-5 6 154
10 MP:0004817 abnormal skeletal muscle mass 6.886E-8 3.209E-6 2.157E-5 3.209E-5 6 166
11 MP:0000747 muscle weakness 1.721E-7 7.289E-6 4.900E-5 8.018E-5 5 96
12 MP:0004091 abnormal Z line morphology 5.814E-7 2.258E-5 1.518E-4 2.709E-4 4 49
13 MP:0030567 abnormal I band morphology 6.845E-7 2.454E-5 1.650E-4 3.190E-4 4 51
14 MP:0009403 increased variability of skeletal muscle fiber size 8.007E-7 2.665E-5 1.792E-4 3.731E-4 4 53
15 MP:0009417 skeletal muscle atrophy 1.721E-6 5.347E-5 3.595E-4 8.021E-4 4 64
16 MP:0002332 abnormal exercise endurance 3.818E-6 1.102E-4 7.405E-4 1.779E-3 4 78
17 MP:0006141 abnormal atrioventricular node conduction 4.018E-6 1.102E-4 7.405E-4 1.873E-3 4 79
18 MP:0001344 blepharoptosis 6.268E-6 1.623E-4 1.091E-3 2.921E-3 3 26
19 MP:0003141 cardiac fibrosis 6.887E-6 1.689E-4 1.135E-3 3.209E-3 5 202
20 MP:0009413 skeletal muscle fiber atrophy 1.566E-5 3.648E-4 2.452E-3 7.295E-3 3 35
21 MP:0000278 abnormal myocardial fiber morphology 1.692E-5 3.755E-4 2.524E-3 7.885E-3 5 243
22 MP:0000748 progressive muscle weakness 1.855E-5 3.759E-4 2.527E-3 8.646E-3 3 37
23 MP:0002753 dilated heart left ventricle 1.855E-5 3.759E-4 2.527E-3 8.646E-3 4 116
24 MP:0010579 increased heart left ventricle size 2.052E-5 3.826E-4 2.572E-3 9.564E-3 4 119
25 MP:0002269 muscular atrophy 2.052E-5 3.826E-4 2.572E-3 9.564E-3 4 119
26 MP:0002841 impaired skeletal muscle contractility 2.537E-5 4.546E-4 3.056E-3 1.182E-2 3 41
27 MP:0003852 skeletal muscle necrosis 3.143E-5 5.425E-4 3.647E-3 1.465E-2 3 44
28 MP:0010578 abnormal heart left ventricle size 3.892E-5 6.477E-4 4.354E-3 1.814E-2 4 140
29 MP:0000751 myopathy 5.836E-5 9.377E-4 6.304E-3 2.719E-2 3 54
30 MP:0003358 abnormal hypaxial muscle morphology 6.723E-5 1.011E-3 6.794E-3 3.133E-2 4 161
31 MP:0008022 dilated heart ventricle 6.723E-5 1.011E-3 6.794E-3 3.133E-2 4 161
32 MP:0005330 cardiomyopathy 7.398E-5 1.077E-3 7.243E-3 3.448E-2 4 165
33 MP:0004085 abnormal heartbeat 8.131E-5 1.148E-3 7.719E-3 3.789E-2 5 337
34 MP:0000738 impaired muscle contractility 8.720E-5 1.195E-3 8.035E-3 4.064E-2 5 342
35 MP:0003921 abnormal heart left ventricle morphology 9.089E-5 1.210E-3 8.135E-3 4.236E-2 5 345
36 MP:0012106 impaired exercise endurance 9.717E-5 1.258E-3 8.456E-3 4.528E-2 3 64
37 MP:0030566 abnormal A band morphology 1.069E-4 1.347E-3 9.052E-3 4.982E-2 2 11
38 MP:0010519 atrioventricular block 1.114E-4 1.367E-3 9.187E-3
5.193E-2
 3 67
39 MP:0000749 muscle degeneration 1.325E-4 1.552E-3 1.043E-2
6.174E-2
 3 71
40 MP:0010508 abnormal heart electrocardiography waveform feature 1.332E-4 1.552E-3 1.043E-2
6.209E-2
 4 192
41 MP:0002899 fatigue 1.499E-4 1.665E-3 1.119E-2
6.984E-2
 3 74
42 MP:0020135 abnormal heart ventricle wall thickness 1.501E-4 1.665E-3 1.119E-2
6.992E-2
 4 198
43 MP:0005608 cardiac interstitial fibrosis 1.820E-4 1.957E-3 1.316E-2
8.483E-2
 3 79
44 MP:0008772 increased heart ventricle size 1.848E-4 1.957E-3 1.316E-2
8.613E-2
 4 209
45 MP:0003137 abnormal impulse conducting system conduction 2.024E-4 2.096E-3 1.409E-2
9.433E-2
 4 214
46 MP:0001625 cardiac hypertrophy 2.331E-4 2.361E-3 1.587E-2
1.086E-1
 4 222
47 MP:0003819 increased left ventricle diastolic pressure 2.631E-4 2.608E-3 1.753E-2
1.226E-1
 2 17
48 MP:0009404 centrally nucleated skeletal muscle fibers 2.768E-4 2.687E-3 1.806E-2
1.290E-1
 3 91
49 MP:0010559 heart block 2.858E-4 2.718E-3 1.827E-2
1.332E-1
 3 92
50 MP:0002833 increased heart weight 2.946E-4 2.745E-3 1.846E-2
1.373E-1
 4 236
Show 45 more annotations

6: Domain [Display Chart] 20 input genes in category / 148 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF08726 EFhand Ca insen Pfam 2.076E-8 1.537E-6 8.570E-6 3.073E-6 3 6
2 IPR014837 EF-hand Ca insen InterPro 2.076E-8 1.537E-6 8.570E-6 3.073E-6 3 6
3 IPR013098 Ig I-set InterPro 1.394E-6 3.362E-5 1.875E-4 2.064E-4 5 190
4 PF07679 I-set Pfam 1.394E-6 3.362E-5 1.875E-4 2.064E-4 5 190
5 PS00019 ACTININ 1 PROSITE 1.817E-6 3.362E-5 1.875E-4 2.690E-4 3 23
6 IPR001589 Actinin actin-bd CS InterPro 1.817E-6 3.362E-5 1.875E-4 2.690E-4 3 23
7 PS00020 ACTININ 2 PROSITE 1.817E-6 3.362E-5 1.875E-4 2.690E-4 3 23
8 PF00435 Spectrin Pfam 1.817E-6 3.362E-5 1.875E-4 2.690E-4 3 23
9 IPR002017 Spectrin repeat InterPro 3.735E-6 5.323E-5 2.969E-4 5.527E-4 3 29
10 IPR003598 Ig sub2 InterPro 3.956E-6 5.323E-5 2.969E-4 5.855E-4 5 235
11 SM00408 IGc2 SMART 3.956E-6 5.323E-5 2.969E-4 5.855E-4 5 235
12 IPR018159 Spectrin/alpha-actinin InterPro 5.059E-6 5.334E-5 2.975E-4 7.487E-4 3 32
13 SM00150 SPEC SMART 5.059E-6 5.334E-5 2.975E-4 7.487E-4 3 32
14 IPR000900 Nebulin repeat InterPro 6.488E-6 5.334E-5 2.975E-4 9.602E-4 2 4
15 SM00227 NEBU SMART 6.488E-6 5.334E-5 2.975E-4 9.602E-4 2 4
16 PF00880 Nebulin Pfam 6.488E-6 5.334E-5 2.975E-4 9.602E-4 2 4
17 IPR013998 Nebulin InterPro 6.488E-6 5.334E-5 2.975E-4 9.602E-4 2 4
18 PS51216 NEBULIN PROSITE 6.488E-6 5.334E-5 2.975E-4 9.602E-4 2 4
19 PF00036 EF-hand 1 Pfam 1.824E-5 1.420E-4 7.923E-4 2.699E-3 4 152
20 SM00054 EFh SMART 2.124E-5 1.571E-4 8.765E-4 3.143E-3 4 158
21 SM00033 CH SMART 4.356E-5 3.070E-4 1.712E-3 6.447E-3 3 65
22 PF00307 CH Pfam 5.441E-5 3.653E-4 2.038E-3 8.052E-3 3 70
23 1.10.418.10 - Gene3D 5.677E-5 3.653E-4 2.038E-3 8.402E-3 3 71
24 PS50021 CH PROSITE 6.169E-5 3.666E-4 2.045E-3 9.130E-3 3 73
25 IPR003599 Ig sub InterPro 6.564E-5 3.666E-4 2.045E-3 9.715E-3 5 421
26 SM00409 IG SMART 6.564E-5 3.666E-4 2.045E-3 9.715E-3 5 421
27 IPR001715 CH-domain InterPro 6.689E-5 3.666E-4 2.045E-3 9.899E-3 3 75
28 PS50002 SH3 PROSITE 7.332E-5 3.710E-4 2.069E-3 1.085E-2 4 217
29 SM00326 SH3 SMART 7.332E-5 3.710E-4 2.069E-3 1.085E-2 4 217
30 PF14604 SH3 9 Pfam 7.520E-5 3.710E-4 2.069E-3 1.113E-2 3 78
31 IPR001452 SH3 domain InterPro 7.871E-5 3.758E-4 2.096E-3 1.165E-2 4 221
32 PS50222 EF HAND 2 PROSITE 9.342E-5 4.260E-4 2.376E-3 1.383E-2 4 231
33 IPR002048 EF hand dom InterPro 9.499E-5 4.260E-4 2.376E-3 1.406E-2 4 232
34 PS50835 IG LIKE PROSITE 1.369E-4 5.958E-4 3.323E-3 2.026E-2 5 492
35 1.10.238.10 - Gene3D 1.496E-4 6.326E-4 3.528E-3 2.214E-2 4 261
36 IPR011992 EF-hand-dom pair InterPro 2.153E-4 8.851E-4 4.937E-3 3.186E-2 4 287
37 PF00041 fn3 Pfam 6.493E-4 2.597E-3 1.449E-2
9.610E-2
 3 162
38 PF00018 SH3 1 Pfam 6.729E-4 2.621E-3 1.462E-2
9.959E-2
 3 164
39 IPR018247 EF Hand 1 Ca BS InterPro 8.125E-4 3.038E-3 1.695E-2
1.202E-1
 3 175
40 SM00060 FN3 SMART 9.542E-4 3.038E-3 1.695E-2
1.412E-1
 3 185
41 PF00047 ig Pfam 1.031E-3 3.038E-3 1.695E-2
1.525E-1
 3 190
42 IPR013151 Immunoglobulin InterPro 1.031E-3 3.038E-3 1.695E-2
1.525E-1
 3 190
43 IPR004168 PPAK motif InterPro 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
44 IPR029637 ACTN4 InterPro 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
45 IPR027698 DES InterPro 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
46 PF09042 Titin Z Pfam 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
47 IPR033017 Palladin InterPro 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
48 IPR015129 Titin Z rpt InterPro 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
49 IPR028516 ArgBP2 InterPro 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
50 PF02818 PPAK Pfam 1.068E-3 3.038E-3 1.695E-2
1.580E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 12 input genes in category / 138 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269869 Striated Muscle Contraction BioSystems: REACTOME 2.378E-13 3.281E-11 1.807E-10 3.281E-11 6 34
2 1269868 Muscle contraction BioSystems: REACTOME 1.531E-8 1.056E-6 5.819E-6 2.113E-6 6 204
3 M13143 uCalpain and friends in Cell spread MSigDB C2 BIOCARTA (v6.0) 5.538E-7 2.547E-5 1.403E-4 7.642E-5 3 18
4 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 8.728E-7 2.781E-5 1.532E-4 1.204E-4 4 83
5 1270243 Nephrin interactions BioSystems: REACTOME 1.043E-6 2.781E-5 1.532E-4 1.439E-4 3 22
6 121494 Dilated cardiomyopathy BioSystems: KEGG 1.209E-6 2.781E-5 1.532E-4 1.669E-4 4 90
7 1269367 Platelet degranulation BioSystems: REACTOME 5.596E-6 9.769E-5 5.381E-4 7.722E-4 4 132
8 M3342 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 5.663E-6 9.769E-5 5.381E-4 7.815E-4 3 38
9 1269365 Response to elevated platelet cytosolic Ca2+ BioSystems: REACTOME 6.487E-6 9.947E-5 5.479E-4 8.952E-4 4 137
10 M12851 Cell to Cell Adhesion Signaling MSigDB C2 BIOCARTA (v6.0) 7.701E-5 1.063E-3 5.853E-3 1.063E-2 2 14
11 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 1.105E-4 1.386E-3 7.636E-3 1.525E-2 4 282
12 1270231 Cell-Cell communication BioSystems: REACTOME 2.498E-4 2.873E-3 1.582E-2 3.448E-2 3 134
13 P00034 Integrin signalling pathway PantherDB 4.771E-4 5.065E-3 2.790E-2
6.584E-2
 3 167
14 169348 Signaling events mediated by focal adhesion kinase BioSystems: Pathway Interaction Database 1.185E-3 1.168E-2
6.435E-2
1.636E-1
 2 54
15 117293 Arrhythmogenic right ventricular cardiomyopathy (ARVC) BioSystems: KEGG 2.097E-3 1.808E-2
9.961E-2
2.894E-1
 2 72
16 83070 Adherens junction BioSystems: KEGG 2.097E-3 1.808E-2
9.961E-2
2.894E-1
 2 72
17 93344 Cardiac muscle contraction BioSystems: KEGG 2.456E-3 1.993E-2
1.098E-1
3.389E-1
 2 78
18 167324 Amoebiasis BioSystems: KEGG 3.693E-3 2.831E-2
1.559E-1
5.096E-1
 2 96
19 83083 Leukocyte transendothelial migration BioSystems: KEGG 5.166E-3 3.752E-2
2.067E-1
7.129E-1
 2 114
20 83122 Systemic lupus erythematosus BioSystems: KEGG 6.970E-3 4.809E-2
2.649E-1
9.618E-1
 2 133
21 1270239 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components BioSystems: REACTOME 7.687E-3 4.990E-2
2.748E-1
1.000E0
 1 8
22 908257 Adrenergic signaling in cardiomyocytes BioSystems: KEGG 8.127E-3 4.990E-2
2.748E-1
1.000E0
 2 144
23 M16334 Eph Kinases and ephrins support platelet aggregation MSigDB C2 BIOCARTA (v6.0) 9.600E-3 4.990E-2
2.748E-1
1.000E0
 1 10
24 83071 Tight junction BioSystems: KEGG 1.118E-2 4.990E-2
2.748E-1
1.000E0
 2 170
25 M8179 Rab GTPases Mark Targets In The Endocytotic Machinery MSigDB C2 BIOCARTA (v6.0) 1.151E-2 4.990E-2
2.748E-1
1.000E0
 1 12
26 M16120 How does salmonella hijack a cell MSigDB C2 BIOCARTA (v6.0) 1.246E-2 4.990E-2
2.748E-1
1.000E0
 1 13
27 M2587 Stress Induction of HSP Regulation MSigDB C2 BIOCARTA (v6.0) 1.437E-2 4.990E-2
2.748E-1
1.000E0
 1 15
28 83067 Focal adhesion BioSystems: KEGG 1.510E-2 4.990E-2
2.748E-1
1.000E0
 2 199
29 1270237 Cell-extracellular matrix interactions BioSystems: REACTOME 1.532E-2 4.990E-2
2.748E-1
1.000E0
 1 16
30 658418 Viral carcinogenesis BioSystems: KEGG 1.539E-2 4.990E-2
2.748E-1
1.000E0
 2 201
31 SMP00306 Pindolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
32 SMP00301 Esmolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
33 SMP00299 Betaxolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
34 SMP00305 Penbutolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
35 SMP00302 Metoprolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
36 SMP00304 Oxprenolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
37 SMP00303 Nadolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
38 SMP00297 Alprenolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
39 SMP00366 Nebivolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
40 1268805 CREB phosphorylation through the activation of CaMKII BioSystems: REACTOME 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
41 SMP00307 Propranolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
42 1268799 Unblocking of NMDA receptor, glutamate binding and activation BioSystems: REACTOME 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
43 SMP00300 Bisoprolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
44 SMP00298 Atenolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
45 SMP00296 Acebutolol Pathway SMPDB 1.627E-2 4.990E-2
2.748E-1
1.000E0
 1 17
Show 40 more annotations

8: Pubmed [Display Chart] 21 input genes in category / 2699 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11309420 Myopalladin, a novel 145-kilodalton sarcomeric protein with multiple roles in Z-disc and I-band protein assemblies. Pubmed 3.956E-23 1.068E-19 9.052E-19 1.068E-19 7 8
2 25987543 Nebulette knockout mice have normal cardiac function, but show Z-line widening and up-regulation of cardiac stress markers. Pubmed 8.472E-21 1.143E-17 9.693E-17 2.287E-17 7 13
3 20301486 Dilated Cardiomyopathy Overview Pubmed 1.652E-17 1.486E-14 1.260E-13 4.458E-14 7 32
4 18157088 Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2. Pubmed 1.100E-16 7.422E-14 6.292E-13 2.969E-13 7 41
5 27171814 Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins. Pubmed 2.328E-16 1.257E-13 1.066E-12 6.284E-13 6 18
6 20368620 Tropomodulin isoforms regulate thin filament pointed-end capping and skeletal muscle physiology. Pubmed 3.782E-15 1.701E-12 1.442E-11 1.021E-11 5 9
7 9501083 Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin. Pubmed 6.752E-14 2.603E-11 2.207E-10 1.822E-10 4 4
8 29078393 HSPB7 is indispensable for heart development by modulating actin filament assembly. Pubmed 1.852E-13 6.248E-11 5.297E-10 4.999E-10 5 17
9 21289070 DOT1L regulates dystrophin expression and is critical for cardiac function. Pubmed 4.635E-13 1.390E-10 1.179E-9 1.251E-9 5 20
10 20215401 CHAP is a newly identified Z-disc protein essential for heart and skeletal muscle function. Pubmed 2.361E-12 6.371E-10 5.401E-9 6.371E-9 4 7
11 23414517 A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Pubmed 4.298E-12 1.055E-9 8.941E-9 1.160E-8 6 82
12 8618961 Molecular diversity of myofibrillar proteins: gene regulation and functional significance. Pubmed 8.492E-12 1.910E-9 1.619E-8 2.292E-8 4 9
13 26075897 Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. Pubmed 1.491E-11 3.096E-9 2.625E-8 4.025E-8 5 38
14 11842093 Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins. Pubmed 2.222E-11 4.285E-9 3.633E-8 5.998E-8 4 11
15 11440986 Differential expression of the actin-binding proteins, alpha-actinin-2 and -3, in different species: implications for the evolution of functional redundancy. Pubmed 9.180E-11 1.652E-8 1.400E-7 2.478E-7 4 15
16 11101506 The interaction of titin and alpha-actinin is controlled by a phospholipid-regulated intramolecular pseudoligand mechanism. Pubmed 1.432E-10 2.274E-8 1.928E-7 3.866E-7 3 3
17 16125169 Involvement of palladin and alpha-actinin in targeting of the Abl/Arg kinase adaptor ArgBP2 to the actin cytoskeleton. Pubmed 1.432E-10 2.274E-8 1.928E-7 3.866E-7 3 3
18 20474083 A novel custom resequencing array for dilated cardiomyopathy. Pubmed 2.603E-10 3.903E-8 3.309E-7 7.025E-7 4 19
19 17875930 Regulation of skeletal muscle sarcomere integrity and postnatal muscle function by Mef2c. Pubmed 4.016E-10 5.705E-8 4.837E-7 1.084E-6 4 21
20 20301725 Hypertrophic Cardiomyopathy Overview Pubmed 4.907E-10 5.726E-8 4.854E-7 1.324E-6 4 22
21 22693585 The Alström syndrome protein, ALMS1, interacts with α-actinin and components of the endosome recycling pathway. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
22 11846417 Titin mutations as the molecular basis for dilated cardiomyopathy. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
23 12482578 Interaction of nebulin SH3 domain with titin PEVK and myopalladin: implications for the signaling and assembly role of titin and nebulin. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
24 16902413 Nebulin regulates thin filament length, contractility, and Z-disk structure in vivo. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
25 16807302 Disruption of alpha-actinin-integrin interactions at focal adhesions renders osteoblasts susceptible to apoptosis. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
26 1629252 Alpha-actinin and vinculin in human neutrophils: reorganization during adhesion and relation to the actin network. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
27 21536590 Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. Pubmed 5.728E-10 5.726E-8 4.854E-7 1.546E-6 3 4
28 19943616 Cell membrane expression of cardiac sodium channel Na(v)1.5 is modulated by alpha-actinin-2 interaction. Pubmed 1.431E-9 1.171E-7 9.926E-7 3.864E-6 3 5
29 24500875 Tropomyosin is required for cardiac morphogenesis, myofibril assembly, and formation of adherens junctions in the developing mouse embryo. Pubmed 1.431E-9 1.171E-7 9.926E-7 3.864E-6 3 5
30 12837758 The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin. Pubmed 1.431E-9 1.171E-7 9.926E-7 3.864E-6 3 5
31 15841212 Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner. Pubmed 1.431E-9 1.171E-7 9.926E-7 3.864E-6 3 5
32 18425115 Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion. Pubmed 1.431E-9 1.171E-7 9.926E-7 3.864E-6 3 5
33 10427098 ZASP: a new Z-band alternatively spliced PDZ-motif protein. Pubmed 1.431E-9 1.171E-7 9.926E-7 3.864E-6 3 5
34 14630798 Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions. Pubmed 1.589E-9 1.262E-7 1.070E-6 4.290E-6 4 29
35 17904117 Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Pubmed 2.104E-9 1.623E-7 1.376E-6 5.679E-6 4 31
36 2455687 Vascular smooth muscle calponin. A novel troponin T-like protein. Pubmed 2.862E-9 1.931E-7 1.637E-6 7.724E-6 3 6
37 16337936 Establishment of cardiac cytoarchitecture in the developing mouse heart. Pubmed 2.862E-9 1.931E-7 1.637E-6 7.724E-6 3 6
38 17987659 Nebulette interacts with filamin C. Pubmed 2.862E-9 1.931E-7 1.637E-6 7.724E-6 3 6
39 14583192 The muscle ankyrin repeat proteins: CARP, ankrd2/Arpp and DARP as a family of titin filament-based stress response molecules. Pubmed 2.862E-9 1.931E-7 1.637E-6 7.724E-6 3 6
40 10929709 Myf-5 revisited: loss of early myotome formation does not lead to a rib phenotype in homozygous Myf-5 mutant mice. Pubmed 2.862E-9 1.931E-7 1.637E-6 7.724E-6 3 6
41 21659647 Desmoplakin and talin2 are novel mRNA targets of fragile X-related protein-1 in cardiac muscle. Pubmed 5.007E-9 3.071E-7 2.604E-6 1.351E-5 3 7
42 11724819 Raver1, a dual compartment protein, is a ligand for PTB/hnRNPI and microfilament attachment proteins. Pubmed 5.007E-9 3.071E-7 2.604E-6 1.351E-5 3 7
43 12782671 Mice deficient in alpha-actinin-4 have severe glomerular disease. Pubmed 5.007E-9 3.071E-7 2.604E-6 1.351E-5 3 7
44 15721864 Temporal and spatial expression pattern of beta1 sodium channel subunit during heart development. Pubmed 5.007E-9 3.071E-7 2.604E-6 1.351E-5 3 7
45 11114196 Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. Pubmed 8.008E-9 4.698E-7 3.983E-6 2.161E-5 3 8
46 7720554 MyoD expression marks the onset of skeletal myogenesis in Myf-5 mutant mice. Pubmed 8.008E-9 4.698E-7 3.983E-6 2.161E-5 3 8
47 7720708 Inactivation of Myf-6 and Myf-5 genes in mice leads to alterations in skeletal muscle development. Pubmed 1.201E-8 6.895E-7 5.846E-6 3.241E-5 3 9
48 24355925 Heparan sulfate deficiency disrupts developmental angiogenesis and causes congenital diaphragmatic hernia. Pubmed 1.715E-8 9.445E-7 8.007E-6 4.628E-5 3 10
49 1991513 Non-viral cellular substrates for human immunodeficiency virus type 1 protease. Pubmed 1.715E-8 9.445E-7 8.007E-6 4.628E-5 3 10
50 22266860 Sp1 phosphorylation by cyclin-dependent kinase 1/cyclin B1 represses its DNA-binding activity during mitosis in cancer cells. Pubmed 2.098E-8 1.132E-6 9.599E-6 5.661E-5 4 54
Show 45 more annotations

9: Interaction [Display Chart] 21 input genes in category / 758 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:TTN TTN interactions 1.234E-16 9.354E-14 6.743E-13 9.354E-14 9 79
2 int:TRIM63 TRIM63 interactions 1.773E-15 4.894E-13 3.528E-12 1.344E-12 9 105
3 int:ACTN2 ACTN2 interactions 1.937E-15 4.894E-13 3.528E-12 1.468E-12 9 106
4 int:MYPN MYPN interactions 1.560E-14 2.956E-12 2.131E-11 1.182E-11 6 17
5 int:ACTN1 ACTN1 interactions 1.662E-13 2.520E-11 1.816E-10 1.260E-10 9 172
6 int:NEB NEB interactions 4.710E-13 5.950E-11 4.289E-10 3.570E-10 6 28
7 int:TRIM55 TRIM55 interactions 9.610E-12 1.041E-9 7.502E-9 7.285E-9 7 93
8 int:MYOZ1 MYOZ1 interactions 1.192E-11 1.130E-9 8.143E-9 9.037E-9 5 18
9 int:MYH2 MYH2 interactions 7.354E-11 5.574E-9 4.018E-8 5.574E-8 5 25
10 int:ACTN3 ACTN3 interactions 7.354E-11 5.574E-9 4.018E-8 5.574E-8 5 25
11 int:ACTN4 ACTN4 interactions 2.868E-10 1.976E-8 1.424E-7 2.174E-7 7 150
12 int:MYOZ2 MYOZ2 interactions 2.638E-9 1.666E-7 1.201E-6 2.000E-6 4 16
13 int:TNNI1 TNNI1 interactions 3.447E-9 2.010E-7 1.449E-6 2.613E-6 4 17
14 int:MYH9 MYH9 interactions 4.185E-9 2.266E-7 1.633E-6 3.172E-6 8 358
15 int:TPM2 TPM2 interactions 4.490E-9 2.269E-7 1.636E-6 3.404E-6 6 121
16 int:ANKRD1 ANKRD1 interactions 8.025E-8 3.578E-6 2.580E-5 6.083E-5 3 8
17 int:XIRP1 XIRP1 interactions 8.025E-8 3.578E-6 2.580E-5 6.083E-5 3 8
18 int:MYOZ3 MYOZ3 interactions 1.203E-7 4.799E-6 3.459E-5 9.118E-5 3 9
19 int:ADORA2A ADORA2A interactions 1.203E-7 4.799E-6 3.459E-5 9.118E-5 3 9
20 int:TPM1 TPM1 interactions 3.258E-7 1.235E-5 8.901E-5 2.470E-4 5 127
21 int:PALLD PALLD interactions 4.452E-7 1.607E-5 1.158E-4 3.375E-4 4 54
22 int:CAPZA2 CAPZA2 interactions 5.216E-7 1.797E-5 1.296E-4 3.954E-4 6 269
23 int:TPM3 TPM3 interactions 6.971E-7 2.298E-5 1.656E-4 5.284E-4 5 148
24 int:SORBS2 SORBS2 interactions 7.307E-7 2.308E-5 1.664E-4 5.539E-4 4 61
25 int:PPP1CB PPP1CB interactions 7.620E-7 2.310E-5 1.665E-4 5.776E-4 6 287
26 int:LDB3 LDB3 interactions 1.619E-6 4.656E-5 3.356E-4 1.227E-3 3 20
27 int:FLNA FLNA interactions 1.658E-6 4.656E-5 3.356E-4 1.257E-3 6 328
28 int:CNN1 CNN1 interactions 2.184E-6 5.911E-5 4.261E-4 1.655E-3 3 22
29 int:ANKRD23 ANKRD23 interactions 4.018E-6 1.050E-4 7.570E-4 3.046E-3 2 3
30 int:TPM4 TPM4 interactions 5.544E-6 1.401E-4 1.010E-3 4.202E-3 4 101
31 int:PDLIM1 PDLIM1 interactions 1.089E-5 2.580E-4 1.860E-3 8.256E-3 3 37
32 int:NEBL NEBL interactions 1.089E-5 2.580E-4 1.860E-3 8.256E-3 3 37
33 int:MYH15 MYH15 interactions 1.337E-5 3.072E-4 2.214E-3 1.014E-2 2 5
34 int:TES TES interactions 1.809E-5 4.032E-4 2.907E-3 1.371E-2 5 288
35 int:MYOM1 MYOM1 interactions 2.005E-5 4.341E-4 3.130E-3 1.519E-2 2 6
36 int:ANLN ANLN interactions 2.580E-5 5.433E-4 3.917E-3 1.956E-2 4 149
37 int:IQGAP1 IQGAP1 interactions 3.231E-5 6.312E-4 4.550E-3 2.449E-2 5 325
38 int:DES DES interactions 3.244E-5 6.312E-4 4.550E-3 2.459E-2 3 53
39 int:PDLIM7 PDLIM7 interactions 3.248E-5 6.312E-4 4.550E-3 2.462E-2 4 158
40 int:SYNPO SYNPO interactions 3.496E-5 6.625E-4 4.775E-3 2.650E-2 4 161
41 int:HSPB2 HSPB2 interactions 3.669E-5 6.783E-4 4.889E-3 2.781E-2 4 163
42 int:MYO18A MYO18A interactions 4.735E-5 8.463E-4 6.100E-3 3.589E-2 4 174
43 int:XIRP2 XIRP2 interactions 4.801E-5 8.463E-4 6.100E-3 3.639E-2 2 9
44 int:MYO19 MYO19 interactions 5.174E-5 8.913E-4 6.425E-3 3.922E-2 4 178
45 int:ISG15 ISG15 interactions 6.669E-5 1.123E-3 8.098E-3
5.055E-2
 4 190
46 int:MICALL2 MICALL2 interactions 7.324E-5 1.207E-3 8.700E-3
5.552E-2
 2 11
47 int:RAVER1 RAVER1 interactions 8.140E-5 1.280E-3 9.228E-3
6.170E-2
 3 72
48 int:MYH8 MYH8 interactions 8.782E-5 1.280E-3 9.228E-3
6.657E-2
 2 12
49 int:TNNT2 TNNT2 interactions 8.782E-5 1.280E-3 9.228E-3
6.657E-2
 2 12
50 int:CLIC5 CLIC5 interactions 8.782E-5 1.280E-3 9.228E-3
6.657E-2
 2 12
Show 45 more annotations

10: Cytoband [Display Chart] 21 input genes in category / 21 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1q42.13 1q42.13 4.909E-4 6.360E-3 2.318E-2 1.031E-2 2 54
2 10q22.3-q23.2 10q22.3-q23.2 6.059E-4 6.360E-3 2.318E-2 1.272E-2 1 1
3 14q22-q24 14q22-q24 1.211E-3 6.360E-3 2.318E-2 2.544E-2 1 2
4 2q22 2q22 1.211E-3 6.360E-3 2.318E-2 2.544E-2 1 2
5 1q42-q43 1q42-q43 4.234E-3 1.270E-2 4.630E-2
8.891E-2
 1 7
6 15q22.1 15q22.1 4.234E-3 1.270E-2 4.630E-2
8.891E-2
 1 7
7 10p12 10p12 4.234E-3 1.270E-2 4.630E-2
8.891E-2
 1 7
8 14q24 14q24 6.645E-3 1.744E-2
6.359E-2
1.396E-1
 1 11
9 2q31 2q31 7.849E-3 1.831E-2
6.676E-2
1.648E-1
 1 13
10 14q32.12 14q32.12 1.743E-2 2.940E-2
1.072E-1
3.660E-1
 1 29
11 18p11.31 18p11.31 1.743E-2 2.940E-2
1.072E-1
3.660E-1
 1 29
12 19q13 19q13 2.040E-2 2.940E-2
1.072E-1
4.285E-1
 1 34
13 4q32.3 4q32.3 2.040E-2 2.940E-2
1.072E-1
4.285E-1
 1 34
14 10q23.31 10q23.31 2.040E-2 2.940E-2
1.072E-1
4.285E-1
 1 34
15 10q21.3 10q21.3 2.100E-2 2.940E-2
1.072E-1
4.410E-1
 1 35
16 4q35.1 4q35.1 2.396E-2 3.141E-2
1.145E-1
5.032E-1
 1 40
17 15q26.3 15q26.3 2.574E-2 3.141E-2
1.145E-1
5.405E-1
 1 43
18 3p21.1 3p21.1 2.692E-2 3.141E-2
1.145E-1
5.653E-1
 1 45
19 10q22.1 10q22.1 2.869E-2 3.171E-2
1.156E-1
6.025E-1
 1 48
Show 14 more annotations

11: Transcription Factor Binding Site [Display Chart] 16 input genes in category / 155 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$SRF 01 V$SRF 01 4.904E-5 7.601E-3 4.275E-2 7.601E-3 3 45
2 V$SRF C V$SRF C 1.742E-4 1.130E-2
6.352E-2
 2.700E-2 4 181
3 V$SRF Q4 V$SRF Q4 2.186E-4 1.130E-2
6.352E-2
 3.389E-2 4 192
4 V$SRF Q6 V$SRF Q6 3.138E-4 1.216E-2
6.839E-2
 4.864E-2 4 211

12: Gene Family [Display Chart] 17 input genes in category / 17 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1112 Actinins genenames.org 2.709E-9 4.605E-8 1.584E-7 4.605E-8 3 4
2 593 Fibronectin type III domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 2.895E-7 2.461E-6 8.465E-6 4.922E-6 5 161
3 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 4.146E-4 2.349E-3 8.080E-3 7.048E-3 3 160
4 1218 LIM domain containing genenames.org 1.363E-3 5.791E-3 1.992E-2 2.317E-2 2 59
5 777 Tropomyosins genenames.org 3.733E-3 1.189E-2 4.089E-2
6.345E-2
 1 4
6 610 Intermediate filaments Type III genenames.org 4.664E-3 1.189E-2 4.089E-2
7.928E-2
 1 5
7 611 Intermediate filaments Type IV|Protein phosphatase 1 regulatory subunits genenames.org 5.594E-3 1.189E-2 4.089E-2
9.510E-2
 1 6
8 929 Actins genenames.org 5.594E-3 1.189E-2 4.089E-2
9.510E-2
 1 6
9 1219 Troponin complex subunits genenames.org 7.452E-3 1.267E-2 4.357E-2
1.267E-1
 1 8
10 658 Fibronectin type III domain containing|I-set domain containing|Myosin binding proteins genenames.org 7.452E-3 1.267E-2 4.357E-2
1.267E-1
 1 8
11 396 A-kinase anchoring proteins genenames.org 2.768E-2 4.277E-2
1.471E-1
4.705E-1
 1 30
Show 6 more annotations

13: Coexpression [Display Chart] 21 input genes in category / 2108 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 1.483E-15 2.247E-12 1.849E-11 3.126E-12 12 483
2 20630075-AF-3 Mouse StemCell GarciaEscudero10 311genes p53 GeneSigDB 2.273E-15 2.247E-12 1.849E-11 4.790E-12 10 228
3 20502458-TableS6b Human Sarcoma Missiaglia10 212genes GeneSigDB 3.198E-15 2.247E-12 1.849E-11 6.740E-12 9 145
4 M2043 Cluster f: genes identifying an intrinsic group in head and neck squamous cell carcinoma (HNSCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.855E-14 1.504E-11 1.238E-10 6.018E-11 7 54
5 M16123 Muscle development genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) but not in the RD cells (embryonal rhabdomyosarcoma, ERMS) after knockdown of PAX3-FOXO1 [GeneID=5077;2308] fusion by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.952E-12 1.666E-9 1.371E-8 8.330E-9 6 50
6 19658189-TableS8c Human EmbryonicStemCell Xu09 63genes GeneSigDB 1.372E-11 4.822E-9 3.969E-8 2.893E-8 6 61
7 M5909 Genes involved in development of skeletal muscle (myogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 3.407E-10 1.026E-7 8.444E-7 7.181E-7 7 200
8 19643001-Additional-File2 Rat Breast Giusti09 300genes GeneSigDB 7.650E-9 2.016E-6 1.659E-5 1.613E-5 6 172
9 M9065 Genes up-regulated in C2AS12 cells (myoblast) by IGF1 [GeneID=3479] vs PDGFB [GeneID=5155]. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.616E-9 2.252E-6 1.854E-5 2.027E-5 5 82
10 19658189-TableS9b Human EmbryonicStemCell Xu09 100genes GeneSigDB 1.457E-8 3.071E-6 2.528E-5 3.071E-5 5 89
11 19658189-TableS9a Human EmbryonicStemCell Xu09 34genes GeneSigDB 2.017E-8 3.865E-6 3.181E-5 4.252E-5 4 33
12 M78 Genes up-regulated in Rh4 cells (alveolar rhabdomyosarcoma, ARMS) after knockdown of the PAX3-FOXO1 [GeneiD=5077;2308] fusion protein by RNAi for 72 hr. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.314E-8 4.065E-6 3.346E-5 4.878E-5 6 207
13 20502458-TableS6f Human Sarcoma Missiaglia10 28genes GeneSigDB 8.481E-7 1.375E-4 1.132E-3 1.788E-3 3 21
14 15892885-tableS1c Human Prostate Chandran05 101genes Tumor v AdjNormal GeneSigDB 1.164E-6 1.637E-4 1.348E-3 2.455E-3 4 89
15 M1466 Genes up-regulated in MEF cells (embryonic fibroblast) expressing ~25% of YY1 [GeneID=7528]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.165E-6 1.637E-4 1.348E-3 2.456E-3 5 214
16 M9331 Genes down-regulated in mouse stroma of pancreatic adenocarcinoma zenografts after treatment with HhAntag, a hedgehog (Hh) pathway inhibitor. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.263E-6 4.299E-4 3.539E-3 6.879E-3 5 264
17 M3001 Genes up-regulated in type 1 (soleus) vs type 2B (EDL) myofibers. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.139E-6 5.133E-4 4.225E-3 8.726E-3 3 35
18 16611997-Table2 Mouse StemCell Affar06 131genes GeneSigDB 4.820E-6 5.644E-4 4.646E-3 1.016E-2 4 127
19 M2571 Genes down-regulated during prostate cancer progression in the JOCK1 model due to inducible activation of FGFR1 [GeneID=2260] gene in prostate. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.913E-6 7.478E-4 6.155E-3 1.457E-2 5 308
20 M9148 Genes up-regulated in CD4 T conv over-expressing: FOXP3 [GeneID=50943] versus IKZF2 and FOXP3 [GeneID=22807;50943]. MSigDB C7: Immunologic Signatures (v6.0) 7.095E-6 7.478E-4 6.155E-3 1.496E-2 4 140
21 17899370-Table2 Human Breast Singer08 06genes GeneSigDB 7.833E-6 7.863E-4 6.472E-3 1.651E-2 2 5
22 M8349 Genes down-regulated in chondrosarcoma and ovarian carcinoma cell lines which developed resistance to trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.156E-5 1.107E-3 9.115E-3 2.436E-2 3 49
23 19010862-TableS2 Human Breast Laere08 205genes GeneSigDB 2.724E-5 2.343E-3 1.928E-2
5.742E-2
 4 197
24 M3245 Genes up-regulated in comparison of naive B cells versus memory B cells. MSigDB C7: Immunologic Signatures (v6.0) 2.778E-5 2.343E-3 1.928E-2
5.857E-2
 4 198
25 M5915 Genes encoding components of apical junction complex. MSigDB H: Hallmark Gene Sets (v6.0) 2.890E-5 2.343E-3 1.928E-2
6.091E-2
 4 200
26 M3448 Genes down-regulated in comparison of intrathymic T progenitor cells (ITTP) versus naive CD4 [GeneID=920] T cells from adult blood. MSigDB C7: Immunologic Signatures (v6.0) 2.890E-5 2.343E-3 1.928E-2
6.091E-2
 4 200
27 15661559-Table3 Human Ovarian Marchini05 70genes GeneSigDB 3.109E-5 2.427E-3 1.998E-2
6.554E-2
 3 68
28 14973550-SuppTable1 Human Colon Bertucci04 245genes GeneSigDB 3.696E-5 2.703E-3 2.225E-2
7.791E-2
 4 213
29 14973550-SuppTable2 Human Colon Bertucci04 244genes GeneSigDB 3.764E-5 2.703E-3 2.225E-2
7.935E-2
 4 214
30 16611997-SuppTable1 Mouse StemCell Affar06 525genes GeneSigDB 3.847E-5 2.703E-3 2.225E-2
8.110E-2
 5 440
31 16284748-TableS2 Rat Bone Voss05 20genes GeneSigDB 4.294E-5 2.920E-3 2.403E-2
9.052E-2
 2 11
32 M17143 Genes down-regulated in primary granulosa cells after stimulation with LH or FSH gonadotrophic hormones for 24 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.503E-5 4.284E-3 3.526E-2
1.371E-1
 3 87
33 M12924 Genes down-regulated in primary granulosa cells in response to forskolin [PubChem=47936]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.729E-5 4.298E-3 3.538E-2
1.418E-1
 3 88
34 M2584 Genes down-regulated in the ventricles of healthy hearts, compared to atria. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.142E-5 5.048E-3 4.155E-2
1.716E-1
 4 261
35 M12300 Up-regulated genesin the left ventricle myocardium of patients with heart failure following implantation of LVAD (left ventricular assist device). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.075E-4 6.474E-3
5.329E-2
2.266E-1
 3 103
36 19303107-Table2 Mouse Bladder Price09 20genes GeneSigDB 1.329E-4 7.784E-3
6.407E-2
2.802E-1
 2 19
37 20877435-Table2 Human MesenchymalStemCells Nekanti09 24genes GeneSigDB 1.476E-4 8.410E-3
6.922E-2
3.112E-1
 2 20
38 M2293 Genes down-regulated in ES (embryonic stem cells) with defficient SUZ12 [GeneID=23512]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.680E-4 9.320E-3
7.671E-2
3.542E-1
 4 315
39 M1236 Genes down-regulated after knockdown of RALA or RALB [GeneiD=5898;5899], which were also differentially expressed in bladder cancer compared to normal bladder urothelium tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.140E-4 1.128E-2
9.281E-2
4.510E-1
 2 24
40 15381369-Table2 Human HeadandNeck Toruner04 33genes GeneSigDB 2.140E-4 1.128E-2
9.281E-2
4.510E-1
 2 24
41 M15472 Down-regulated genes distinguishing between early gastric cancer (EGC) and normal tissue samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.979E-4 1.532E-2
1.261E-1
6.280E-1
 4 366
42 M3034 Genes down-regulated in NIH3T3 cells (fibroblasts) transformed by expression of contitutively active (Q63L) form of RHOA [GeneID=387] off plasmid vector; their expression reverted completely after treatment with Y27632 [PubChem=123862], an inhibitor of ROCK proteins. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.139E-4 1.575E-2
1.297E-1
6.617E-1
 2 29
43 19305503-TableS1 Rat Brain Greco09 425genes GeneSigDB 3.681E-4 1.754E-2
1.444E-1
7.760E-1
 4 387
44 M4995 Genes specifically up-regulated in Cluster IIb of urothelial cell carcinom (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.791E-4 1.754E-2
1.444E-1
7.991E-1
 4 390
45 15574765-Table1 Mouse Breast Wang04 34genes GeneSigDB 3.828E-4 1.754E-2
1.444E-1
8.070E-1
 2 32
46 14695345-Table1a Mouse Viral Politi04 40genes UpRegulated GeneSigDB 3.828E-4 1.754E-2
1.444E-1
8.070E-1
 2 32
47 M7429 Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 24 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.073E-4 1.827E-2
1.504E-1
8.586E-1
 2 33
48 M6700 Genes up-regulated in endothelial cells: interferon alpha versus interferon beta. MSigDB C7: Immunologic Signatures (v6.0) 4.464E-4 1.960E-2
1.614E-1
9.410E-1
 3 167
49 M2385 Genes up-regulated in MEF cells (embryonic fibroblast) with ELAVL1 [GeneID=1994] knocked out. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.622E-4 1.988E-2
1.637E-1
9.743E-1
 3 169
50 19658189-TableS8a Human EmbryonicStemCell Xu09 36genes GeneSigDB 4.852E-4 2.005E-2
1.651E-1
1.000E0
 2 36
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 21 input genes in category / 2185 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PCBC ctl geo-heart 500 geo heart top-relative-expression-ranked 500 PCBC 6.869E-17 1.501E-13 1.241E-12 1.501E-13 13 499
2 geo heart 1000 K5 geo heart top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 6.942E-16 7.585E-13 6.270E-12 1.517E-12 12 428
3 skeletal muscle skeletal muscle Human Protein Atlas 1.752E-15 1.276E-12 1.055E-11 3.829E-12 11 320
4 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/cardiac muscle cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/cardiac muscle cell Tabula Muris Consortium 5.507E-14 3.008E-11 2.487E-10 1.203E-10 9 187
5 heart muscle heart muscle Human Protein Atlas 9.263E-14 4.048E-11 3.346E-10 2.024E-10 9 198
6 BM Top 100 - heart atrium BM Top 100 - heart atrium Body Map 6.914E-13 2.518E-10 2.082E-9 1.511E-9 7 79
7 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma TCGA-Bone and Soft Tissue 2.352E-12 7.342E-10 6.070E-9 5.140E-9 8 172
8 PCBC ctl geo-heart 100 geo heart top-relative-expression-ranked 100 PCBC 3.773E-12 1.031E-9 8.520E-9 8.245E-9 7 100
9 gudmap developingLowerUrinaryTract P1 bladder J 1000 k2 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.888E-11 1.187E-8 9.811E-8 1.068E-7 8 251
10 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.883E-11 1.286E-8 1.063E-7 1.286E-7 9 406
11 BM Top 100 - skeletal muscle BM Top 100 - skeletal muscle Body Map 6.986E-11 1.388E-8 1.147E-7 1.526E-7 6 75
12 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 200 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.160E-10 2.112E-8 1.746E-7 2.534E-7 7 162
13 geo heart 500 K3 geo heart top-relative-expression-ranked 500 k-means-cluster#3 PCBC 2.838E-10 4.770E-8 3.943E-7 6.200E-7 7 184
14 gudmap developingLowerUrinaryTract P1 bladder B 500 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.534E-10 1.480E-7 1.223E-6 2.083E-6 6 115
15 gudmap developingLowerUrinaryTract P1 bladder B 200 k2 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.016E-9 1.480E-7 1.223E-6 2.220E-6 5 50
16 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.542E-9 2.063E-7 1.705E-6 3.368E-6 8 388
17 gudmap developingLowerUrinaryTract P1 bladder 500 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.605E-9 2.063E-7 1.705E-6 3.507E-6 8 390
18 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Cd9 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Cd9 BrainMap 2.630E-9 3.192E-7 2.639E-6 5.746E-6 6 136
19 gudmap developingLowerUrinaryTract P1 bladder J 200 k5 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.327E-9 6.126E-7 5.064E-6 1.164E-5 5 69
20 BM Top 100 - heart ventricle BM Top 100 - heart ventricle Body Map 6.164E-9 6.734E-7 5.567E-6 1.347E-5 5 71
21 BM Top 100 - tongue main corpus BM Top 100 - tongue main corpus Body Map 1.132E-8 1.148E-6 9.491E-6 2.473E-5 5 80
22 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Acta2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Acta2 BrainMap 1.156E-8 1.148E-6 9.491E-6 2.526E-5 6 174
23 BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5.Cnn1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Mural.Rgs5.Acta2.Acta2,Rgs5 Mural.Rgs5.Acta2.Acta2,Rgs5 Subtype Mural.Rgs5.Acta2.Acta2,Rgs5.Cnn1 Top 200 Genes BrainMap 1.447E-8 1.375E-6 1.136E-5 3.162E-5 7 324
24 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 100 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.835E-8 1.671E-6 1.381E-5 4.010E-5 5 88
25 gudmap developingLowerUrinaryTract P1 bladder B 1000 k1 DevelopingLowerUrinaryTract P1 bladder B emap-30374 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.082E-8 1.819E-6 1.504E-5 4.549E-5 6 192
26 gudmap developingLowerUrinaryTract P1 bladder J 500 k4 DevelopingLowerUrinaryTract P1 bladder J emap-30374 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.266E-8 3.585E-6 2.964E-5 9.322E-5 5 104
27 gudmap developingLowerUrinaryTract P1 bladder 500 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.724E-8 3.823E-6 3.161E-5 1.032E-4 7 385
28 gudmap developingLowerUrinaryTract adult bladder 500 k4 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.923E-8 3.837E-6 3.172E-5 1.076E-4 5 107
29 gudmap developingLowerUrinaryTract adult bladder 200 k4 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.092E-8 3.837E-6 3.172E-5 1.113E-4 4 39
30 ratio DE vs SC 1000 K4 ratio induced-DefinitiveEndoderm vs StemCell top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 6.750E-8 4.916E-6 4.064E-5 1.475E-4 6 234
31 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma/3/4 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma /Conventional Leiomyosarcoma/3/4 TCGA-Bone and Soft Tissue 2.332E-7 1.644E-5 1.359E-4 5.096E-4 5 146
32 Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma Sample Type by Project: Shred 1/TCGA-Bone and Soft Tissue/Sarcoma TCGA-Bone and Soft Tissue 2.413E-7 1.648E-5 1.362E-4 5.272E-4 5 147
33 gudmap developingLowerUrinaryTract adult bladder 1000 k1 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.496E-7 1.653E-5 1.366E-4 5.453E-4 5 148
34 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 200 k4 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.774E-7 1.783E-5 1.474E-4 6.061E-4 3 14
35 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/2 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Signet/2/2 TCGA-Stomach 3.243E-7 2.025E-5 1.674E-4 7.086E-4 5 156
36 gudmap developingLowerUrinaryTract P1 bladder 200 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.678E-7 2.173E-5 1.797E-4 8.036E-4 5 160
37 JC iEC 2500 K3 JC iEC top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 3.680E-7 2.173E-5 1.797E-4 8.041E-4 6 312
38 gudmap developingLowerUrinaryTract P1 bladder 200 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.912E-7 2.249E-5 1.859E-4 8.547E-4 5 162
39 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 200 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.157E-7 2.329E-5 1.925E-4 9.083E-4 5 164
40 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/smooth muscle cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Heart/smooth muscle cell Tabula Muris Consortium 4.548E-7 2.484E-5 2.054E-4 9.938E-4 5 167
41 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/5 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/5 TCGA-Esophagus 6.067E-7 3.233E-5 2.673E-4 1.326E-3 5 177
42 gudmap developingLowerUrinaryTract adult bladder 100 k4 DevelopingLowerUrinaryTract adult bladder emap-29457 k-means-cluster#4 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 7.362E-7 3.830E-5 3.166E-4 1.609E-3 3 19
43 BM Top 100 - tongue superior part w papillae BM Top 100 - tongue superior part w papillae Body Map 9.545E-7 4.850E-5 4.009E-4 2.086E-3 4 80
44 Lungmap Mouse Lung PND1 MyoFB Subtype All subclasses Lungmap Mouse Lung PND1 MyoFB Subtype All subclasses Lungmap CCHMC 1.003E-6 4.983E-5 4.119E-4 2.193E-3 4 81
45 Facebase ST1 Univ 500 3 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 3 FaceBase_ST1 1.054E-6 5.119E-5 4.232E-4 2.304E-3 4 82
46 BM Top 100 - oral mucosa BM Top 100 - oral mucosa Body Map 1.162E-6 5.517E-5 4.561E-4 2.538E-3 4 84
47 gudmap developingLowerUrinaryTract P1 ureter 500 k1 DevelopingLowerUrinaryTract P1 ureter emap-30363 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.277E-6 5.840E-5 4.828E-4 2.790E-3 4 86
48 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 1.283E-6 5.840E-5 4.828E-4 2.803E-3 5 206
49 Facebase ST1 Univ 500 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 FaceBase_ST1 2.288E-6 1.020E-4 8.435E-4 4.999E-3 6 427
50 Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-E Lungmap Mouse Lung PND1 MyoFB Subtype MyoFB-E Lungmap CCHMC 2.450E-6 1.060E-4 8.766E-4 5.353E-3 5 235
Show 45 more annotations

15: Computational [Display Chart] 19 input genes in category / 104 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M12699 MODULE 202 Genes in the cancer module 202. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.312E-9 1.364E-7 7.131E-7 1.364E-7 5 28
2 M8295 GNF2 TTN Neighborhood of TTN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.335E-7 6.945E-6 3.630E-5 1.389E-5 4 26
3 M8715 GNF2 MYL2 Neighborhood of MYL2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.756E-5 9.552E-4 4.993E-3 2.866E-3 3 32
4 M5499 MODULE 512 Muscle genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.291E-5 1.116E-3 5.831E-3 4.462E-3 3 37
5 M15550 MODULE 387 Genes in the cancer module 387. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.003E-4 1.680E-3 8.782E-3 1.043E-2 3 49
6 M6788 MODULE 201 Genes in the cancer module 201. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.066E-4 1.680E-3 8.782E-3 1.108E-2 3 50
7 M11492 MODULE 329 Genes in the cancer module 329. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.131E-4 1.680E-3 8.782E-3 1.176E-2 3 51
8 M16395 MODULE 47 ECM and collagens. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.312E-4 9.506E-3 4.968E-2
7.605E-2
 4 225
9 M11742 GNF2 MYL3 Neighborhood of MYL3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.528E-3 1.766E-2
9.228E-2
1.589E-1
 2 31
Show 4 more annotations

16: MicroRNA [Display Chart] 21 input genes in category / 701 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-129-5p:PITA hsa-miR-129-5p:PITA TOP PITA 2.539E-7 1.780E-4 1.269E-3 1.780E-4 5 487
2 hsa-miR-587:PITA hsa-miR-587:PITA TOP PITA 5.946E-6 2.084E-3 1.486E-2 4.168E-3 4 415
3 hsa-miR-6892-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.881E-5 1.513E-2
1.079E-1
 4.824E-2 2 42
4 hsa-miR-3162-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.632E-5 1.513E-2
1.079E-1
6.051E-2
 2 47
5 hsa-miR-4475:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.228E-4 1.698E-2
1.211E-1
8.606E-2
 2 56
6 hsa-miR-18b*:mirSVR highEffct hsa-miR-18b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.453E-4 1.698E-2
1.211E-1
1.019E-1
 3 354
7 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 1.889E-4 1.858E-2
1.324E-1
1.324E-1
 3 387
8 hsa-miR-1293:PITA hsa-miR-1293:PITA TOP PITA 2.147E-4 1.858E-2
1.324E-1
1.505E-1
 2 74
9 hsa-miR-4732-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.385E-4 1.858E-2
1.324E-1
1.672E-1
 2 78
10 hsa-miR-1914:mirSVR highEffct hsa-miR-1914:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.919E-4 2.046E-2
1.459E-1
2.046E-1
 3 449
11 hsa-miR-4304:mirSVR lowEffct hsa-miR-4304:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.504E-4 2.233E-2
1.592E-1
2.456E-1
 3 478
12 AAACCAC,MIR-140:MSigDB AAACCAC,MIR-140:MSigDB MSigDB 3.994E-4 2.333E-2
1.664E-1
2.800E-1
 2 101
13 hsa-miR-1224-3p:PITA hsa-miR-1224-3p:PITA TOP PITA 4.398E-4 2.371E-2
1.691E-1
3.083E-1
 2 106
14 hsa-miR-502-5p:PITA hsa-miR-502-5p:PITA TOP PITA 6.399E-4 2.976E-2
2.122E-1
4.485E-1
 2 128
15 hsa-miR-133a-3p:Functional MTI Functional MTI miRTarbase 6.599E-4 2.976E-2
2.122E-1
4.626E-1
 2 130
16 hsa-miR-1268:mirSVR highEffct hsa-miR-1268:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.904E-4 2.976E-2
2.122E-1
4.840E-1
 2 133
17 hsa-miR-362-5p:PITA hsa-miR-362-5p:PITA TOP PITA 7.217E-4 2.976E-2
2.122E-1
5.059E-1
 2 136
18 hsa-miR-532-3p:PITA hsa-miR-532-3p:PITA TOP PITA 9.592E-4 3.618E-2
2.580E-1
6.724E-1
 2 157
19 hsa-miR-3919:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.008E-3 3.618E-2
2.580E-1
7.067E-1
 2 161
20 hsa-miR-1260:PITA hsa-miR-1260:PITA TOP PITA 1.058E-3 3.618E-2
2.580E-1
7.418E-1
 2 165
21 hsa-miR-642:PITA hsa-miR-642:PITA TOP PITA 1.084E-3 3.618E-2
2.580E-1
7.597E-1
 2 167
22 GCAAAAA,MIR-129:MSigDB GCAAAAA,MIR-129:MSigDB MSigDB 1.175E-3 3.745E-2
2.670E-1
8.239E-1
 2 174
23 hsa-miR-182-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.243E-3 3.788E-2
2.701E-1
8.713E-1
 2 179
24 hsa-miR-299-5p:TargetScan hsa-miR-299-5p TargetScan 1.502E-3 4.194E-2
2.990E-1
1.000E0
 2 197
25 CACCAGC,MIR-138:MSigDB CACCAGC,MIR-138:MSigDB MSigDB 1.547E-3 4.194E-2
2.990E-1
1.000E0
 2 200
26 hsa-miR-96-5p:Functional MTI Functional MTI miRTarbase 1.562E-3 4.194E-2
2.990E-1
1.000E0
 2 201
27 hsa-miR-6769b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.719E-3 4.194E-2
2.990E-1
1.000E0
 2 211
28 hsa-miR-4723-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.735E-3 4.194E-2
2.990E-1
1.000E0
 2 212
29 hsa-miR-3183:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.735E-3 4.194E-2
2.990E-1
1.000E0
 2 212
30 TAGCTTT,MIR-9:MSigDB TAGCTTT,MIR-9:MSigDB MSigDB 1.950E-3 4.319E-2
3.080E-1
1.000E0
 2 225
31 hsa-miR-1226-3p:Functional MTI Functional MTI miRTarbase 1.985E-3 4.319E-2
3.080E-1
1.000E0
 2 227
32 CGTCTTA,MIR-208:MSigDB CGTCTTA,MIR-208:MSigDB MSigDB 2.033E-3 4.319E-2
3.080E-1
1.000E0
 1 7
33 hsa-miR-6761-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.033E-3 4.319E-2
3.080E-1
1.000E0
 1 7
34 hsa-miR-297:PITA hsa-miR-297:PITA TOP PITA 2.107E-3 4.343E-2
3.097E-1
1.000E0
 2 234
35 hsa-miR-1279:PITA hsa-miR-1279:PITA TOP PITA 2.178E-3 4.362E-2
3.110E-1
1.000E0
 2 238
36 hsa-miR-505:PITA hsa-miR-505:PITA TOP PITA 2.250E-3 4.382E-2
3.124E-1
1.000E0
 2 242
37 hsa-miR-6825-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.323E-3 4.390E-2
3.130E-1
1.000E0
 1 8
38 hsa-miR-659:PITA hsa-miR-659:PITA TOP PITA 2.380E-3 4.390E-2
3.130E-1
1.000E0
 2 249
39 hsa-miR-3662:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.455E-3 4.413E-2
3.147E-1
1.000E0
 2 253
40 hsa-miR-185-5p:TargetScan hsa-miR-185-5p TargetScan 2.669E-3 4.621E-2
3.295E-1
1.000E0
 2 264
41 TATTATA,MIR-374:MSigDB TATTATA,MIR-374:MSigDB MSigDB 2.708E-3 4.621E-2
3.295E-1
1.000E0
 2 266
42 hsa-miR-6832-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.768E-3 4.621E-2
3.295E-1
1.000E0
 2 269
43 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 3.036E-3 4.950E-2
3.529E-1
1.000E0
 2 282
44 hsa-miR-4684-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.250E-3 4.992E-2
3.560E-1
1.000E0
 2 292
45 hsa-miR-409-3p:PITA hsa-miR-409-3p:PITA TOP PITA 3.294E-3 4.992E-2
3.560E-1
1.000E0
 2 294
46 hsa-miR-324-5p:Functional MTI Functional MTI miRTarbase 3.360E-3 4.992E-2
3.560E-1
1.000E0
 2 297
47 hsa-miR-507:PITA hsa-miR-507:PITA TOP PITA 3.516E-3 4.992E-2
3.560E-1
1.000E0
 2 304
48 hsa-miR-155:PITA hsa-miR-155:PITA TOP PITA 3.516E-3 4.992E-2
3.560E-1
1.000E0
 2 304
49 hsa-miR-557:PITA hsa-miR-557:PITA TOP PITA 3.516E-3 4.992E-2
3.560E-1
1.000E0
 2 304
50 hsa-miR-488-3p:TargetScan hsa-miR-488-3p TargetScan 3.561E-3 4.992E-2
3.560E-1
1.000E0
 2 306
Show 45 more annotations

17: Drug [Display Chart] 21 input genes in category / 5340 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000008330 TCNB Stitch 1.614E-20 8.618E-17 7.894E-16 8.618E-17 11 119
2 CID000093117 conen Stitch 1.371E-15 3.661E-12 3.353E-11 7.321E-12 6 15
3 CID000122259 NpCaM Stitch 6.562E-10 1.168E-6 1.070E-5 3.504E-6 5 48
4 CID000031423 pyrene Stitch 1.086E-7 1.450E-4 1.329E-3 5.801E-4 5 131
5 CID000004752 NSC 523214 Stitch 1.931E-7 1.759E-4 1.611E-3 1.031E-3 5 147
6 ctd:D013792 Thalidomide CTD 1.977E-7 1.759E-4 1.611E-3 1.055E-3 7 497
7 CID005459371 1tjp Stitch 3.536E-6 2.697E-3 2.471E-2 1.888E-2 4 116
8 CID000092905 Topanol Ca Stitch 1.686E-5 7.877E-3
7.216E-2
9.003E-2
 2 7
9 3075 UP Cantharidin [56-25-7]; Up 200; 20.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.099E-5 7.877E-3
7.216E-2
1.121E-1
 4 182
10 ctd:D013096 Spermine CTD 2.567E-5 7.877E-3
7.216E-2
1.371E-1
 3 63
11 4846 UP Quercetine dihydrate [6151-25-3]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.642E-5 7.877E-3
7.216E-2
1.411E-1
 4 193
12 2480 UP Atovaquone [95233-18-4]; Up 200; 11uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.751E-5 7.877E-3
7.216E-2
1.469E-1
 4 195
13 4433 UP 2-propylpentanoic acid; Up 200; 1000uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.863E-5 7.877E-3
7.216E-2
1.529E-1
 4 197
14 3076 UP Aminohippuric acid [61-78-9]; Up 200; 20.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.863E-5 7.877E-3
7.216E-2
1.529E-1
 4 197
15 4391 UP Sparteine (-) [90-39-1]; Up 200; 17uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.863E-5 7.877E-3
7.216E-2
1.529E-1
 4 197
16 2714 UP Drofenine hydrochloride [548-66-3]; Up 200; 11.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.921E-5 7.877E-3
7.216E-2
1.560E-1
 4 198
17 3023 DN Iodixanol [92339-11-2]; Down 200; 2.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.921E-5 7.877E-3
7.216E-2
1.560E-1
 4 198
18 CID006399216 kt S Stitch 2.953E-5 7.877E-3
7.216E-2
1.577E-1
 3 66
19 4256 UP Tocainide hydrochloride; Up 200; 17.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.979E-5 7.877E-3
7.216E-2
1.591E-1
 4 199
20 3777 UP 0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.979E-5 7.877E-3
7.216E-2
1.591E-1
 4 199
21 ctd:D020106 Acrylamide CTD 3.098E-5 7.877E-3
7.216E-2
1.654E-1
 4 201
22 ctd:D001761 Bleomycin CTD 3.389E-5 8.181E-3
7.494E-2
1.810E-1
 5 423
23 CID003359490 AC1MNW2N Stitch 3.524E-5 8.181E-3
7.494E-2
1.882E-1
 3 70
24 ctd:D003630 Daunorubicin CTD 4.177E-5 9.295E-3
8.514E-2
2.231E-1
 4 217
25 CID000091750 SIRIUS Stitch 4.690E-5 1.002E-2
9.176E-2
2.504E-1
 3 77
26 ctd:D008942 Mitoxantrone CTD 6.911E-5 1.388E-2
1.271E-1
3.691E-1
 4 247
27 CID000183793 NP-EGTA Stitch 7.278E-5 1.388E-2
1.271E-1
3.886E-1
 2 14
28 CID006440832 goniodomin A Stitch 7.278E-5 1.388E-2
1.271E-1
3.886E-1
 2 14
29 CID003037868 A-G-T-C Stitch 8.393E-5 1.545E-2
1.416E-1
4.482E-1
 2 15
30 CID000003083 DM-nitrophen Stitch 9.586E-5 1.651E-2
1.513E-1
5.119E-1
 2 16
31 ctd:D019274 Botulinum Toxins, Type A CTD 9.586E-5 1.651E-2
1.513E-1
5.119E-1
 2 16
32 CID000137371 DABMI Stitch 1.086E-4 1.757E-2
1.610E-1
5.798E-1
 2 17
33 ctd:C487049 BXL628 CTD 1.086E-4 1.757E-2
1.610E-1
5.798E-1
 2 17
34 ctd:C099813 bromochloroacetic acid CTD 1.321E-4 2.074E-2
1.900E-1
7.052E-1
 3 109
35 CID000131289 benzophenone-4-iodoacetamide Stitch 1.364E-4 2.081E-2
1.906E-1
7.283E-1
 2 19
36 CID000104008 dansylaziridine Stitch 2.013E-4 2.417E-2
2.214E-1
1.000E0
 2 23
37 CID005288569 AC1NRBPQ Stitch 2.594E-4 2.417E-2
2.214E-1
1.000E0
 3 137
38 ctd:C096900 thrombin receptor-activating peptide SFLLRNPNDKY CTD 3.448E-4 2.417E-2
2.214E-1
1.000E0
 2 30
39 CID000006035 bromodeoxyuridine Stitch 3.465E-4 2.417E-2
2.214E-1
1.000E0
 4 376
40 ctd:C032910 triadimefon CTD 4.297E-4 2.417E-2
2.214E-1
1.000E0
 4 398
41 ctd:C100573 prostaglandin A1 CTD 4.437E-4 2.417E-2
2.214E-1
1.000E0
 2 34
42 CID000076765 N,N'-p-phenylenedimaleimide Stitch 4.437E-4 2.417E-2
2.214E-1
1.000E0
 2 34
43 CID005311324 AC1NSKFN Stitch 4.977E-4 2.417E-2
2.214E-1
1.000E0
 2 36
44 CID004369485 S H Y Stitch 5.548E-4 2.417E-2
2.214E-1
1.000E0
 2 38
45 CID000107855 12-deoxyphorbol 13-isobutyrate Stitch 5.845E-4 2.417E-2
2.214E-1
1.000E0
 2 39
46 ctd:D064791 Desoxycorticosterone Acetate CTD 5.845E-4 2.417E-2
2.214E-1
1.000E0
 2 39
47 2949 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Up 6.244E-4 2.417E-2
2.214E-1
1.000E0
 3 185
48 6902 UP 0297417-0002B [362658-29-5]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.443E-4 2.417E-2
2.214E-1
1.000E0
 3 187
49 6995 UP LY 294002; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.443E-4 2.417E-2
2.214E-1
1.000E0
 3 187
50 3291 UP Doxorubicin hydrochloride [25316-40-9]; Up 200; 6.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 6.851E-4 2.417E-2
2.214E-1
1.000E0
 3 191
Show 45 more annotations

18: Disease [Display Chart] 20 input genes in category / 482 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3809288 LEFT VENTRICULAR NONCOMPACTION 8 DisGeNET Curated 8.056E-17 1.942E-14 1.312E-13 3.883E-14 8 40
2 C3715165 LEFT VENTRICULAR NONCOMPACTION 10 DisGeNET Curated 8.056E-17 1.942E-14 1.312E-13 3.883E-14 8 40
3 C0007193 Cardiomyopathy, Dilated DisGeNET Curated 2.384E-14 3.831E-12 2.588E-11 1.149E-11 11 323
4 cv:C0007193 Primary dilated cardiomyopathy Clinical Variations 4.495E-13 5.417E-11 3.660E-10 2.167E-10 6 27
5 C1449563 Cardiomyopathy, Familial Idiopathic DisGeNET Curated 4.496E-12 4.334E-10 2.928E-9 2.167E-9 10 365
6 C0751657 Nemaline Myopathy, Autosomal Recessive DisGeNET BeFree 2.526E-11 2.029E-9 1.371E-8 1.218E-8 4 6
7 C4021726 EMG: myopathic abnormalities DisGeNET Curated 4.330E-11 2.981E-9 2.014E-8 2.087E-8 5 22
8 C2678065 Myofibrillar Myopathy DisGeNET Curated 1.067E-9 6.428E-8 4.343E-7 5.143E-7 5 40
9 C0007194 Hypertrophic Cardiomyopathy DisGeNET Curated 1.472E-8 7.881E-7 5.325E-6 7.093E-6 7 256
10 C0206157 Myopathies, Nemaline DisGeNET BeFree 2.099E-8 1.012E-6 6.834E-6 1.012E-5 4 25
11 C1843637 Neck flexor weakness DisGeNET Curated 3.208E-8 1.406E-6 9.496E-6 1.546E-5 3 6
12 C0270960 Congenital myopathy (disorder) DisGeNET BeFree 9.688E-8 3.891E-6 2.629E-5 4.670E-5 4 36
13 C0349788 Arrhythmogenic Right Ventricular Dysplasia DisGeNET BeFree 1.659E-7 6.151E-6 4.156E-5 7.996E-5 4 41
14 C0026848 Myopathy DisGeNET Curated 2.445E-7 8.416E-6 5.686E-5 1.178E-4 7 386
15 C1533847 Disorder of skeletal muscle DisGeNET Curated 4.562E-7 1.466E-5 9.904E-5 2.199E-4 3 13
16 C0878544 Cardiomyopathies DisGeNET Curated 5.315E-7 1.601E-5 1.082E-4 2.562E-4 7 433
17 C1858719 Facial muscle weakness of muscles innervated by CN VII DisGeNET Curated 6.858E-7 1.944E-5 1.314E-4 3.305E-4 4 58
18 C0427055 Facial Paresis DisGeNET Curated 7.869E-7 2.107E-5 1.424E-4 3.793E-4 4 60
19 C0376175 Bell Palsy DisGeNET Curated 8.415E-7 2.135E-5 1.442E-4 4.056E-4 4 61
20 C4021727 EMG: neuropathic changes DisGeNET Curated 8.911E-7 2.148E-5 1.451E-4 4.295E-4 3 16
21 C0007196 Restrictive cardiomyopathy DisGeNET Curated 1.081E-6 2.482E-5 1.677E-4 5.211E-4 3 17
22 C4082299 Bulbar palsy DisGeNET Curated 1.808E-6 3.848E-5 2.600E-4 8.716E-4 3 20
23 C0686353 Muscular Dystrophies, Limb-Girdle DisGeNET Curated 1.836E-6 3.848E-5 2.600E-4 8.851E-4 4 74
24 C1301959 Bulbar weakness DisGeNET Curated 2.108E-6 4.064E-5 2.746E-4 1.016E-3 3 21
25 C0751336 Distal Muscular Dystrophies DisGeNET Curated 2.108E-6 4.064E-5 2.746E-4 1.016E-3 3 21
26 C4025565 Late-onset distal muscle weakness DisGeNET Curated 4.338E-6 7.210E-5 4.872E-4 2.091E-3 2 3
27 C0751656 Nemaline Myopathy, Autosomal Dominant DisGeNET BeFree 4.338E-6 7.210E-5 4.872E-4 2.091E-3 2 3
28 C0340429 Familial restrictive cardiomyopathy (disorder) DisGeNET BeFree 4.338E-6 7.210E-5 4.872E-4 2.091E-3 2 3
29 C0544966 Autophagic vaculoes (finding) DisGeNET Curated 4.338E-6 7.210E-5 4.872E-4 2.091E-3 2 3
30 C0027868 Neuromuscular Diseases DisGeNET Curated 5.210E-6 8.371E-5 5.656E-4 2.511E-3 4 96
31 C0030552 Paresis DisGeNET Curated 9.282E-6 1.443E-4 9.751E-4 4.474E-3 4 111
32 C3806467 Respiratory insufficiency due to muscle weakness DisGeNET Curated 1.216E-5 1.832E-4 1.238E-3 5.862E-3 3 37
33 C0949658 Cardiomyopathy, Hypertrophic, Familial DisGeNET Curated 1.543E-5 2.253E-4 1.522E-3 7.436E-3 3 40
34 C0151786 Muscle Weakness DisGeNET Curated 1.862E-5 2.640E-4 1.784E-3 8.977E-3 5 280
35 C0546125 Nemaline Myopathy, Childhood Onset DisGeNET Curated 2.164E-5 2.799E-4 1.891E-3 1.043E-2 2 6
36 C0014117 Endocardial Fibroelastosis DisGeNET Curated 2.164E-5 2.799E-4 1.891E-3 1.043E-2 2 6
37 C3710589 Cap Myopathy DisGeNET Curated 2.164E-5 2.799E-4 1.891E-3 1.043E-2 2 6
38 C0340427 Familial dilated cardiomyopathy DisGeNET Curated 2.207E-5 2.799E-4 1.891E-3 1.064E-2 3 45
39 C1838869 Proximal neurogenic muscle weakness DisGeNET Curated 2.684E-5 3.234E-4 2.185E-3 1.294E-2 3 48
40 C0221629 Proximal muscle weakness DisGeNET Curated 2.684E-5 3.234E-4 2.185E-3 1.294E-2 3 48
41 C3808039 Nemaline rods DisGeNET Curated 3.028E-5 3.475E-4 2.348E-3 1.459E-2 2 7
42 C1836057 Muscle fiber splitting DisGeNET Curated 3.028E-5 3.475E-4 2.348E-3 1.459E-2 2 7
43 C0427065 Distal muscle weakness DisGeNET Curated 5.804E-5 6.217E-4 4.200E-3 2.798E-2 3 62
44 C0746674 Generalized muscle weakness DisGeNET Curated 5.804E-5 6.217E-4 4.200E-3 2.798E-2 3 62
45 C1864696 Distal limb muscle weakness due to peripheral neuropathy DisGeNET Curated 5.804E-5 6.217E-4 4.200E-3 2.798E-2 3 62
46 C1834696 Hyporeflexia of lower limbs DisGeNET Curated 6.474E-5 6.241E-4 4.216E-3 3.120E-2 2 10
47 C1842170 Centrally nucleated skeletal muscle fibers DisGeNET Curated 6.474E-5 6.241E-4 4.216E-3 3.120E-2 2 10
48 C1854387 Type 1 muscle fiber predominance DisGeNET Curated 6.474E-5 6.241E-4 4.216E-3 3.120E-2 2 10
49 C0410180 Eichsfeld type congenital muscular dystrophy DisGeNET Curated 6.474E-5 6.241E-4 4.216E-3 3.120E-2 2 10
50 C1861861 CARDIOMYOPATHY, FAMILIAL RESTRICTIVE, 1 (disorder) DisGeNET Curated 6.474E-5 6.241E-4 4.216E-3 3.120E-2 2 10
Show 45 more annotations