Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc11_16, positive side

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1: GO: Molecular Function [Display Chart] 16 input genes in category / 52 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005242 inward rectifier potassium channel activity 1.324E-33 6.882E-32 3.123E-31 6.882E-32 12 24
2 GO:0015467 G-protein activated inward rectifier potassium channel activity 5.688E-33 1.479E-31 6.712E-31 2.958E-31 10 10
3 GO:0005249 voltage-gated potassium channel activity 1.524E-25 2.641E-24 1.199E-23 7.924E-24 12 91
4 GO:0005267 potassium channel activity 6.231E-24 8.100E-23 3.676E-22 3.240E-22 12 122
5 GO:0022843 voltage-gated cation channel activity 3.809E-23 3.962E-22 1.798E-21 1.981E-21 12 141
6 GO:0015079 potassium ion transmembrane transporter activity 5.880E-23 4.527E-22 2.054E-21 3.058E-21 12 146
7 GO:0022834 ligand-gated channel activity 6.965E-23 4.527E-22 2.054E-21 3.622E-21 12 148
8 GO:0015276 ligand-gated ion channel activity 6.965E-23 4.527E-22 2.054E-21 3.622E-21 12 148
9 GO:0022832 voltage-gated channel activity 2.551E-21 1.326E-20 6.019E-20 1.326E-19 12 198
10 GO:0005244 voltage-gated ion channel activity 2.551E-21 1.326E-20 6.019E-20 1.326E-19 12 198
11 GO:0005261 cation channel activity 5.233E-19 2.474E-18 1.123E-17 2.721E-17 12 306
12 GO:0022836 gated channel activity 1.359E-18 5.887E-18 2.671E-17 7.064E-17 12 331
13 GO:0015077 monovalent inorganic cation transmembrane transporter activity 6.167E-18 2.467E-17 1.119E-16 3.207E-16 12 375
14 GO:0005216 ion channel activity 2.721E-17 9.985E-17 4.531E-16 1.415E-15 12 424
15 GO:0046873 metal ion transmembrane transporter activity 2.880E-17 9.985E-17 4.531E-16 1.498E-15 12 426
16 GO:0022838 substrate-specific channel activity 4.028E-17 1.309E-16 5.940E-16 2.094E-15 12 438
17 GO:0015267 channel activity 9.424E-17 2.793E-16 1.268E-15 4.901E-15 12 470
18 GO:0022803 passive transmembrane transporter activity 9.669E-17 2.793E-16 1.268E-15 5.028E-15 12 471
19 GO:0015272 ATP-activated inward rectifier potassium channel activity 5.166E-9 1.414E-8 6.416E-8 2.686E-7 3 5
20 GO:0030165 PDZ domain binding 3.224E-8 8.384E-8 3.804E-7 1.677E-6 5 114
21 GO:0097016 L27 domain binding 2.067E-6 5.117E-6 2.322E-5 1.075E-4 2 3
22 GO:0030955 potassium ion binding 7.190E-5 1.699E-4 7.712E-4 3.739E-3 2 15
23 GO:0031420 alkali metal ion binding 1.726E-4 3.901E-4 1.770E-3 8.973E-3 2 23
24 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1.146E-3 2.483E-3 1.127E-2
5.960E-2
 2 59
25 GO:1902936 phosphatidylinositol bisphosphate binding 2.199E-3 4.574E-3 2.076E-2
1.144E-1
 2 82
26 GO:0031072 heat shock protein binding 3.641E-3 7.283E-3 3.305E-2
1.893E-1
 2 106
27 GO:0032795 heterotrimeric G-protein binding 5.134E-3 9.769E-3 4.433E-2
2.670E-1
 1 6
28 GO:1901981 phosphatidylinositol phosphate binding 5.260E-3 9.769E-3 4.433E-2
2.735E-1
 2 128
29 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization 5.987E-3 1.074E-2 4.872E-2
3.113E-1
 1 7
30 GO:0001609 G protein-coupled adenosine receptor activity 6.840E-3 1.186E-2
5.380E-2
3.557E-1
 1 8
31 GO:0035091 phosphatidylinositol binding 1.451E-2 2.428E-2
1.102E-1
7.545E-1
 2 217
32 GO:0050750 low-density lipoprotein particle receptor binding 1.533E-2 2.428E-2
1.102E-1
7.971E-1
 1 18
33 GO:0008022 protein C-terminus binding 1.541E-2 2.428E-2
1.102E-1
8.013E-1
 2 224
34 GO:0030506 ankyrin binding 1.786E-2 2.732E-2
1.240E-1
9.288E-1
 1 21
35 GO:0070325 lipoprotein particle receptor binding 1.955E-2 2.904E-2
1.318E-1
1.000E0
 1 23
36 GO:0031683 G-protein beta/gamma-subunit complex binding 2.039E-2 2.945E-2
1.336E-1
1.000E0
 1 24
37 GO:0035586 purinergic receptor activity 2.291E-2 3.220E-2
1.461E-1
1.000E0
 1 27
38 GO:0001965 G-protein alpha-subunit binding 2.793E-2 3.822E-2
1.735E-1
1.000E0
 1 33
39 GO:0004629 phospholipase C activity 3.127E-2 4.169E-2
1.892E-1
1.000E0
 1 37
Show 34 more annotations

2: GO: Biological Process [Display Chart] 16 input genes in category / 409 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0010107 potassium ion import 2.600E-32 1.064E-29 7.011E-29 1.064E-29 12 29
2 GO:0006813 potassium ion transport 3.739E-23 7.646E-21 5.041E-20 1.529E-20 13 222
3 GO:0071805 potassium ion transmembrane transport 8.644E-22 8.838E-20 5.826E-19 3.535E-19 12 181
4 GO:0071804 cellular potassium ion transport 8.644E-22 8.838E-20 5.826E-19 3.535E-19 12 181
5 GO:0034765 regulation of ion transmembrane transport 6.532E-17 5.343E-15 3.522E-14 2.671E-14 12 455
6 GO:0034762 regulation of transmembrane transport 1.043E-16 7.106E-15 4.685E-14 4.264E-14 12 473
7 GO:0008016 regulation of heart contraction 1.382E-6 8.073E-5 5.322E-4 5.651E-4 5 242
8 GO:0060047 heart contraction 2.635E-6 1.263E-4 8.323E-4 1.078E-3 5 276
9 GO:0003015 heart process 2.778E-6 1.263E-4 8.323E-4 1.136E-3 5 279
10 GO:0061337 cardiac conduction 3.986E-6 1.630E-4 1.075E-3 1.630E-3 4 131
11 GO:1903522 regulation of blood circulation 6.687E-6 2.355E-4 1.553E-3 2.735E-3 5 334
12 GO:1903361 protein localization to basolateral plasma membrane 6.910E-6 2.355E-4 1.553E-3 2.826E-3 2 5
13 GO:0060075 regulation of resting membrane potential 1.036E-5 3.259E-4 2.149E-3 4.237E-3 2 6
14 GO:0042391 regulation of membrane potential 1.435E-5 4.193E-4 2.764E-3 5.870E-3 5 391
15 GO:0045199 maintenance of epithelial cell apical/basal polarity 1.932E-5 5.115E-4 3.372E-3 7.902E-3 2 8
16 GO:0035637 multicellular organismal signaling 2.001E-5 5.115E-4 3.372E-3 8.184E-3 4 197
17 GO:0035090 maintenance of apical/basal cell polarity 2.483E-5 5.973E-4 3.937E-3 1.015E-2 2 9
18 GO:0051289 protein homotetramerization 2.993E-5 6.801E-4 4.483E-3 1.224E-2 3 72
19 GO:0043266 regulation of potassium ion transport 6.036E-5 1.280E-3 8.439E-3 2.469E-2 3 91
20 GO:0030011 maintenance of cell polarity 6.260E-5 1.280E-3 8.439E-3 2.560E-2 2 14
21 GO:0055075 potassium ion homeostasis 1.173E-4 2.285E-3 1.506E-2 4.799E-2 2 19
22 GO:0051262 protein tetramerization 2.761E-4 5.133E-3 3.384E-2
1.129E-1
 3 152
23 GO:0090075 relaxation of muscle 2.968E-4 5.273E-3 3.476E-2
1.214E-1
 2 30
24 GO:0055067 monovalent inorganic cation homeostasis 3.094E-4 5.273E-3 3.476E-2
1.265E-1
 3 158
25 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity 3.381E-4 5.532E-3 3.647E-2
1.383E-1
 2 32
26 GO:0061245 establishment or maintenance of bipolar cell polarity 5.296E-4 8.023E-3
5.289E-2
2.166E-1
 2 40
27 GO:0035088 establishment or maintenance of apical/basal cell polarity 5.296E-4 8.023E-3
5.289E-2
2.166E-1
 2 40
28 GO:0043268 positive regulation of potassium ion transport 6.122E-4 8.943E-3
5.895E-2
2.504E-1
 2 43
29 GO:0023061 signal release 7.119E-4 9.497E-3
6.261E-2
2.912E-1
 4 498
30 GO:0006836 neurotransmitter transport 7.301E-4 9.497E-3
6.261E-2
2.986E-1
 3 212
31 GO:0001505 regulation of neurotransmitter levels 7.502E-4 9.497E-3
6.261E-2
3.069E-1
 3 214
32 GO:0051930 regulation of sensory perception of pain 7.949E-4 9.497E-3
6.261E-2
3.251E-1
 2 49
33 GO:0051931 regulation of sensory perception 7.949E-4 9.497E-3
6.261E-2
3.251E-1
 2 49
34 GO:0032244 positive regulation of nucleoside transport 8.592E-4 9.497E-3
6.261E-2
3.514E-1
 1 1
35 GO:0014861 regulation of skeletal muscle contraction via regulation of action potential 8.592E-4 9.497E-3
6.261E-2
3.514E-1
 1 1
36 GO:0100001 regulation of skeletal muscle contraction by action potential 8.592E-4 9.497E-3
6.261E-2
3.514E-1
 1 1
37 GO:1900128 regulation of G-protein activated inward rectifier potassium channel activity 8.592E-4 9.497E-3
6.261E-2
3.514E-1
 1 1
38 GO:1904062 regulation of cation transmembrane transport 1.021E-3 1.098E-2
7.241E-2
4.174E-1
 3 238
39 GO:1901379 regulation of potassium ion transmembrane transport 1.438E-3 1.495E-2
9.853E-2
5.880E-1
 2 66
40 GO:0055117 regulation of cardiac muscle contraction 1.615E-3 1.495E-2
9.853E-2
6.607E-1
 2 70
41 GO:0043270 positive regulation of ion transport 1.696E-3 1.495E-2
9.853E-2
6.937E-1
 3 284
42 GO:0090076 relaxation of skeletal muscle 1.718E-3 1.495E-2
9.853E-2
7.025E-1
 1 2
43 GO:1900453 negative regulation of long-term synaptic depression 1.718E-3 1.495E-2
9.853E-2
7.025E-1
 1 2
44 GO:0070256 negative regulation of mucus secretion 1.718E-3 1.495E-2
9.853E-2
7.025E-1
 1 2
45 GO:0032900 negative regulation of neurotrophin production 1.718E-3 1.495E-2
9.853E-2
7.025E-1
 1 2
46 GO:0032242 regulation of nucleoside transport 1.718E-3 1.495E-2
9.853E-2
7.025E-1
 1 2
47 GO:0042323 negative regulation of circadian sleep/wake cycle, non-REM sleep 1.718E-3 1.495E-2
9.853E-2
7.025E-1
 1 2
48 GO:0051260 protein homooligomerization 1.984E-3 1.690E-2
1.114E-1
8.114E-1
 3 300
49 GO:0007588 excretion 2.103E-3 1.755E-2
1.157E-1
8.602E-1
 2 80
50 GO:0071260 cellular response to mechanical stimulus 2.261E-3 1.850E-2
1.219E-1
9.249E-1
 2 83
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 16 input genes in category / 60 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008076 voltage-gated potassium channel complex 2.690E-15 8.827E-14 4.131E-13 1.614E-13 8 92
2 GO:0034705 potassium channel complex 2.942E-15 8.827E-14 4.131E-13 1.765E-13 8 93
3 GO:0034703 cation channel complex 5.442E-13 1.088E-11 5.093E-11 3.265E-11 8 176
4 GO:0034702 ion channel complex 3.104E-11 4.656E-10 2.179E-9 1.862E-9 8 291
5 GO:1902495 transmembrane transporter complex 7.868E-11 9.094E-10 4.256E-9 4.721E-9 8 327
6 GO:1990351 transporter complex 9.094E-11 9.094E-10 4.256E-9 5.456E-9 8 333
7 GO:0030315 T-tubule 1.109E-9 9.502E-9 4.447E-8 6.652E-8 5 60
8 GO:0016323 basolateral plasma membrane 2.977E-8 2.232E-7 1.045E-6 1.786E-6 6 244
9 GO:0042383 sarcolemma 1.228E-7 8.190E-7 3.833E-6 7.371E-6 5 152
10 GO:0098794 postsynapse 2.500E-5 1.500E-4 7.019E-4 1.500E-3 5 449
11 GO:0045211 postsynaptic membrane 3.078E-5 1.679E-4 7.856E-4 1.847E-3 4 225
12 GO:0097060 synaptic membrane 9.187E-5 4.593E-4 2.150E-3 5.512E-3 4 298
13 GO:0030673 axolemma 1.120E-4 5.170E-4 2.420E-3 6.722E-3 2 19
14 GO:0098793 presynapse 1.545E-4 6.622E-4 3.099E-3 9.270E-3 4 341
15 GO:0005911 cell-cell junction 3.366E-4 1.346E-3 6.300E-3 2.019E-2 4 418
16 GO:0032589 neuron projection membrane 7.592E-4 2.847E-3 1.332E-2 4.555E-2 2 49
17 GO:0014069 postsynaptic density 8.866E-4 2.955E-3 1.383E-2
5.319E-2
 3 232
18 GO:0099572 postsynaptic specialization 8.866E-4 2.955E-3 1.383E-2
5.319E-2
 3 232
19 GO:0014704 intercalated disc 1.062E-3 3.355E-3 1.570E-2
6.375E-2
 2 58
20 GO:0060076 excitatory synapse 1.126E-3 3.377E-3 1.581E-2
6.755E-2
 3 252
21 GO:0044291 cell-cell contact zone 1.587E-3 4.535E-3 2.122E-2
9.523E-2
 2 71
22 GO:0044304 main axon 1.723E-3 4.698E-3 2.198E-2
1.034E-1
 2 74
23 GO:0097025 MPP7-DLG1-LIN7 complex 2.516E-3 6.291E-3 2.944E-2
1.510E-1
 1 3
24 GO:0008282 inward rectifying potassium channel 2.516E-3 6.291E-3 2.944E-2
1.510E-1
 1 3
25 GO:0005923 bicellular tight junction 4.097E-3 9.834E-3 4.602E-2
2.458E-1
 2 115
26 GO:0070160 tight junction 4.309E-3 9.943E-3 4.653E-2
2.585E-1
 2 118
27 GO:0043296 apical junction complex 5.281E-3 1.174E-2
5.492E-2
3.169E-1
 2 131
28 GO:0031256 leading edge membrane 6.867E-3 1.427E-2
6.678E-2
4.120E-1
 2 150
29 GO:0043197 dendritic spine 6.956E-3 1.427E-2
6.678E-2
4.173E-1
 2 151
30 GO:0044309 neuron spine 7.135E-3 1.427E-2
6.678E-2
4.281E-1
 2 153
31 GO:0070852 cell body fiber 1.003E-2 1.941E-2
9.084E-2
6.018E-1
 1 12
32 GO:0097449 astrocyte projection 1.086E-2 2.036E-2
9.530E-2
6.517E-1
 1 13
33 GO:0098858 actin-based cell projection 1.239E-2 2.253E-2
1.054E-1
7.436E-1
 2 204
34 GO:0032279 asymmetric synapse 1.335E-2 2.356E-2
1.103E-1
8.011E-1
 1 16
35 GO:0097386 glial cell projection 1.501E-2 2.573E-2
1.204E-1
9.005E-1
 1 18
36 GO:0032809 neuronal cell body membrane 2.408E-2 3.904E-2
1.827E-1
1.000E0
 1 29
37 GO:0044298 cell body membrane 2.408E-2 3.904E-2
1.827E-1
1.000E0
 1 29
38 GO:0033267 axon part 2.706E-2 4.188E-2
1.960E-1
1.000E0
 2 309
39 GO:0009897 external side of plasma membrane 2.722E-2 4.188E-2
1.960E-1
1.000E0
 2 310
40 GO:0048786 presynaptic active zone 3.062E-2 4.488E-2
2.100E-1
1.000E0
 1 37
41 GO:0031253 cell projection membrane 3.090E-2 4.488E-2
2.100E-1
1.000E0
 2 332
42 GO:0016324 apical plasma membrane 3.142E-2 4.488E-2
2.100E-1
1.000E0
 2 335
43 GO:0005790 smooth endoplasmic reticulum 3.225E-2 4.500E-2
2.106E-1
1.000E0
 1 39
44 GO:0032420 stereocilium 3.632E-2 4.952E-2
2.318E-1
1.000E0
 1 44
Show 39 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 518 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0025072 Prominent U wave 1.896E-6 2.455E-4 1.677E-3 9.822E-4 2 2
2 HP:0025070 Abnormal U wave 1.896E-6 2.455E-4 1.677E-3 9.822E-4 2 2
3 HP:0005147 Bidirectional ventricular ectopy 1.896E-6 2.455E-4 1.677E-3 9.822E-4 2 2
4 HP:0005478 Prominent frontal sinuses 1.896E-6 2.455E-4 1.677E-3 9.822E-4 2 2
5 HP:0040084 Abnormal circulating renin 4.024E-6 4.169E-4 2.847E-3 2.084E-3 3 24
6 HP:0000847 Abnormality of renin-angiotensin system 9.811E-6 8.407E-4 5.740E-3 5.082E-3 3 32
7 HP:0003779 Antegonial notching of mandible 1.136E-5 8.407E-4 5.740E-3 5.885E-3 2 4
8 HP:0200114 Metabolic alkalosis 1.944E-5 1.130E-3 7.716E-3 1.007E-2 3 40
9 HP:0010344 Deviation of the 5th toe 2.836E-5 1.130E-3 7.716E-3 1.469E-2 2 6
10 HP:0001864 Clinodactyly of the 5th toe 2.836E-5 1.130E-3 7.716E-3 1.469E-2 2 6
11 HP:3000003 Abnormal mandibular ramus morphology 2.836E-5 1.130E-3 7.716E-3 1.469E-2 2 6
12 HP:0000128 Renal potassium wasting 2.836E-5 1.130E-3 7.716E-3 1.469E-2 2 6
13 HP:0003778 Short mandibular rami 2.836E-5 1.130E-3 7.716E-3 1.469E-2 2 6
14 HP:0002855 Abnormality of aldosterone production 3.605E-5 1.242E-3 8.480E-3 1.867E-2 3 49
15 HP:0000859 Hyperaldosteronism 3.605E-5 1.242E-3 8.480E-3 1.867E-2 3 49
16 HP:0010753 Midline defect of mandible 3.968E-5 1.242E-3 8.480E-3 2.055E-2 2 7
17 HP:0001959 Polydipsia 4.316E-5 1.242E-3 8.480E-3 2.235E-2 3 52
18 HP:0030082 Abnormal drinking behavior 4.316E-5 1.242E-3 8.480E-3 2.235E-2 3 52
19 HP:0000103 Polyuria 5.113E-5 1.394E-3 9.519E-3 2.649E-2 3 55
20 HP:0008153 Periodic hypokalemic paresis 6.792E-5 1.759E-3 1.201E-2 3.518E-2 2 9
21 HP:0000696 Delayed eruption of permanent teeth 8.484E-5 1.998E-3 1.364E-2 4.395E-2 2 10
22 HP:0001960 Hypokalemic metabolic alkalosis 8.484E-5 1.998E-3 1.364E-2 4.395E-2 2 10
23 HP:0002717 Adrenal overactivity 9.265E-5 2.087E-3 1.425E-2 4.799E-2 3 67
24 HP:0006335 Persistence of primary teeth 1.243E-4 2.534E-3 1.730E-2
6.436E-2
 2 12
25 HP:0001863 Toe clinodactyly 1.243E-4 2.534E-3 1.730E-2
6.436E-2
 2 12
26 HP:0002900 Hypokalemia 1.406E-4 2.534E-3 1.730E-2
7.281E-2
 3 77
27 HP:0012590 Abnormal urine output 1.461E-4 2.534E-3 1.730E-2
7.568E-2
 3 78
28 HP:0012598 Abnormal urine potassium concentration 1.467E-4 2.534E-3 1.730E-2
7.601E-2
 2 13
29 HP:0001090 Abnormally large globe 1.467E-4 2.534E-3 1.730E-2
7.601E-2
 2 13
30 HP:0001949 Hypokalemic alkalosis 1.467E-4 2.534E-3 1.730E-2
7.601E-2
 2 13
31 HP:0001948 Alkalosis 1.576E-4 2.633E-3 1.798E-2
8.162E-2
 3 80
32 HP:0011733 Abnormality of adrenal physiology 1.701E-4 2.754E-3 1.880E-2
8.813E-2
 4 229
33 HP:0011280 Abnormality of urine calcium concentration 1.823E-4 2.838E-3 1.938E-2
9.442E-2
 3 84
34 HP:0011865 Abnormal urine cation concentration 1.955E-4 2.838E-3 1.938E-2
1.013E-1
 3 86
35 HP:0011036 Abnormality of renal excretion 1.955E-4 2.838E-3 1.938E-2
1.013E-1
 3 86
36 HP:0000848 Increased circulating renin level 1.973E-4 2.838E-3 1.938E-2
1.022E-1
 2 15
37 HP:0003768 Periodic paralysis 2.253E-4 3.071E-3 2.097E-2
1.167E-1
 2 16
38 HP:0004757 Paroxysmal atrial fibrillation 2.253E-4 3.071E-3 2.097E-2
1.167E-1
 2 16
39 HP:0040202 Abnormal consumption behavior 2.390E-4 3.174E-3 2.167E-2
1.238E-1
 3 92
40 HP:0000849 Adrenocortical abnormality 2.712E-4 3.512E-3 2.398E-2
1.405E-1
 3 96
41 HP:0011042 Abnormality of potassium homeostasis 2.972E-4 3.754E-3 2.564E-2
1.539E-1
 3 99
42 HP:0000325 Triangular face 3.439E-4 4.241E-3 2.896E-2
1.781E-1
 3 104
43 HP:0002917 Hypomagnesemia 4.318E-4 5.202E-3 3.552E-2
2.237E-1
 2 22
44 HP:0004921 Abnormal magnesium concentration 5.596E-4 6.588E-3 4.499E-2
2.899E-1
 2 25
45 HP:0000834 Abnormality of the adrenal glands 5.789E-4 6.664E-3 4.550E-2
2.999E-1
 4 314
46 HP:0001649 Tachycardia 7.262E-4 8.177E-3
5.584E-2
3.762E-1
 3 134
47 HP:0012591 Abnormal urinary electrolyte concentration 9.337E-4 1.029E-2
7.027E-2
4.837E-1
 3 146
48 HP:0006682 Ventricular extrasystoles 9.793E-4 1.057E-2
7.217E-2
5.073E-1
 2 33
49 HP:0000127 Renal salt wasting 1.166E-3 1.233E-2
8.417E-2
6.040E-1
 2 36
50 HP:0000210 Micrognathia 1.299E-3 1.346E-2
9.191E-2
6.730E-1
 2 38
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 14 input genes in category / 407 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011295 abnormal tubuloglomerular feedback response 5.089E-6 2.071E-3 1.364E-2 2.071E-3 2 3
2 MP:0002910 abnormal excitatory postsynaptic currents 3.401E-5 6.922E-3 4.560E-2 1.384E-2 4 146
3 MP:0002272 abnormal nervous system electrophysiology 7.530E-5 1.022E-2
6.729E-2
 3.065E-2 5 359
4 MP:0002064 seizures 1.116E-4 1.104E-2
7.275E-2
 4.542E-2 5 390
5 MP:0003997 tonic-clonic seizures 1.357E-4 1.104E-2
7.275E-2
5.522E-2
 3 77
6 MP:0001762 polyuria 2.774E-4 1.618E-2
1.066E-1
1.129E-1
 3 98
7 MP:0001429 dehydration 2.945E-4 1.618E-2
1.066E-1
1.198E-1
 3 100
8 MP:0003477 abnormal nerve fiber response 3.181E-4 1.618E-2
1.066E-1
1.295E-1
 2 20
9 MP:0006316 increased urine sodium level 7.719E-4 3.490E-2
2.299E-1
3.141E-1
 2 31
10 MP:0001756 abnormal urination 1.249E-3 4.586E-2
3.021E-1
5.082E-1
 3 164
11 MP:0011977 abnormal sodium ion homeostasis 1.271E-3 4.586E-2
3.021E-1
5.172E-1
 3 165
12 MP:0011297 absent tubuloglomerular feedback response 1.352E-3 4.586E-2
3.021E-1
5.503E-1
 1 1
13 MP:0000947 convulsive seizures 1.556E-3 4.871E-2
3.208E-1
6.332E-1
 3 177
Show 8 more annotations

6: Domain [Display Chart] 16 input genes in category / 37 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01007 IRK Pfam 8.508E-37 7.870E-36 3.307E-35 3.148E-35 12 16
2 IPR016449 K chnl inward-rec Kir InterPro 8.508E-37 7.870E-36 3.307E-35 3.148E-35 12 16
3 2.60.40.1400 - Gene3D 8.508E-37 7.870E-36 3.307E-35 3.148E-35 12 16
4 IPR013518 K chnl inward-rec Kir cyto InterPro 8.508E-37 7.870E-36 3.307E-35 3.148E-35 12 16
5 IPR014756 Ig E-set InterPro 7.941E-25 5.877E-24 2.469E-23 2.938E-23 12 104
6 IPR013673 K chnl inward-rec Kir N InterPro 2.050E-6 1.084E-5 4.554E-5 7.586E-5 2 3
7 PF08466 IRK N Pfam 2.050E-6 1.084E-5 4.554E-5 7.586E-5 2 3
8 PF02828 L27 Pfam 3.065E-5 1.260E-4 5.294E-4 1.134E-3 2 10
9 IPR014775 L27 C InterPro 3.065E-5 1.260E-4 5.294E-4 1.134E-3 2 10
10 IPR004172 L27 dom InterPro 5.304E-5 1.636E-4 6.872E-4 1.963E-3 2 13
11 SM00569 L27 SMART 5.304E-5 1.636E-4 6.872E-4 1.963E-3 2 13
12 PS51022 L27 PROSITE 5.304E-5 1.636E-4 6.872E-4 1.963E-3 2 13
13 PF00595 PDZ Pfam 2.175E-4 5.905E-4 2.481E-3 8.047E-3 3 141
14 SM00228 PDZ SMART 2.509E-4 5.905E-4 2.481E-3 9.282E-3 3 148
15 2.30.42.10 - Gene3D 2.610E-4 5.905E-4 2.481E-3 9.656E-3 3 150
16 PS50106 PDZ PROSITE 2.661E-4 5.905E-4 2.481E-3 9.846E-3 3 151
17 IPR001478 PDZ InterPro 2.713E-4 5.905E-4 2.481E-3 1.004E-2 3 152
18 IPR031197 NHERF-2 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
19 IPR003268 K chnl inward-rec Kir1.1 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
20 IPR003275 K chnl inward-rec Kir3.2 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
21 IPR003277 K chnl inward-rec Kir3.4 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
22 IPR003271 K chnl inward-rec Kir2.1 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
23 IPR001068 Adeno A1 rcpt InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
24 IPR003269 K chnl inward-rec Kir1.2 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
25 IPR003270 K chnl inward-rec Kir1.3 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
26 IPR008061 K chnl inward-rec Kir5 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
27 IPR003273 K chnl inward-rec Kir2.3 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
28 IPR003276 K chnl inward-rec Kir3.3 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
29 IPR003279 K chnl inward-rec Kir6.2 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
30 IPR003274 K chnl inward-rec Kir3.1 InterPro 8.540E-4 1.053E-3 4.425E-3 3.160E-2 1 1
31 PD283022 EBP50 C-term ProDom 1.707E-3 1.805E-3 7.583E-3
6.317E-2
 1 2
32 IPR015098 EBP50 C-term InterPro 1.707E-3 1.805E-3 7.583E-3
6.317E-2
 1 2
33 IPR003272 K chnl inward-rec Kir2.2 InterPro 1.707E-3 1.805E-3 7.583E-3
6.317E-2
 1 2
34 IPR017300 NHERF-1/NHERF-2 InterPro 1.707E-3 1.805E-3 7.583E-3
6.317E-2
 1 2
35 PF09007 EBP50 C Pfam 1.707E-3 1.805E-3 7.583E-3
6.317E-2
 1 2
36 IPR001634 Adenosn rcpt InterPro 3.412E-3 3.507E-3 1.473E-2
1.262E-1
 1 4
Show 31 more annotations

7: Pathway [Display Chart] 16 input genes in category / 100 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268824 Inwardly rectifying K+ channels BioSystems: REACTOME 8.868E-30 8.868E-28 4.600E-27 8.868E-28 12 31
2 1268819 Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits BioSystems: REACTOME 1.058E-24 2.646E-23 1.373E-22 1.058E-22 10 25
3 1268826 Activation of G protein gated Potassium channels BioSystems: REACTOME 1.058E-24 2.646E-23 1.373E-22 1.058E-22 10 25
4 1268825 G protein gated Potassium channels BioSystems: REACTOME 1.058E-24 2.646E-23 1.373E-22 1.058E-22 10 25
5 1268821 Potassium Channels BioSystems: REACTOME 6.466E-23 1.293E-21 6.709E-21 6.466E-21 12 100
6 1268816 Activation of GABAB receptors BioSystems: REACTOME 2.727E-22 3.896E-21 2.021E-20 2.727E-20 10 40
7 1268815 GABA B receptor activation BioSystems: REACTOME 2.727E-22 3.896E-21 2.021E-20 2.727E-20 10 40
8 1268813 GABA receptor activation BioSystems: REACTOME 1.137E-20 1.422E-19 7.375E-19 1.137E-18 10 56
9 1268763 Neuronal System BioSystems: REACTOME 1.770E-20 1.967E-19 1.020E-18 1.770E-18 14 351
10 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 1.050E-18 1.050E-17 5.447E-17 1.050E-16 12 218
11 1268786 Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell BioSystems: REACTOME 2.914E-16 2.649E-15 1.374E-14 2.914E-14 10 147
12 952859 Oxytocin signaling pathway BioSystems: KEGG 3.846E-10 3.205E-9 1.663E-8 3.846E-8 7 153
13 SMP00324 Procainamide (Antiarrhythmic) Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
14 SMP00332 Ibutilide Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
15 SMP00330 Tocainide Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
16 SMP00327 Phenytoin (Antiarrhythmic) Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
17 SMP00329 Mexiletine Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
18 SMP00326 Fosphenytoin (Antiarrhythmic) Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
19 SMP00325 Disopyramide Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
20 SMP00328 Lidocaine (Antiarrhythmic) Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
21 SMP00331 Flecainide Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
22 SMP00323 Quinidine Pathway SMPDB 7.466E-10 3.394E-9 1.760E-8 7.466E-8 5 37
23 1268827 Potassium transport channels BioSystems: REACTOME 1.742E-9 7.572E-9 3.928E-8 1.742E-7 3 3
24 PW:0000274 neuron-to-neuron signaling via the chemical synapse Pathway Ontology 6.961E-9 2.617E-8 1.358E-7 6.961E-7 3 4
25 1268829 Classical Kir channels BioSystems: REACTOME 6.961E-9 2.617E-8 1.358E-7 6.961E-7 3 4
26 SMP00375 Verapamil Pathway SMPDB 7.067E-9 2.617E-8 1.358E-7 7.067E-7 5 57
27 SMP00359 Diltiazem Pathway SMPDB 7.067E-9 2.617E-8 1.358E-7 7.067E-7 5 57
28 154409 Gastric acid secretion BioSystems: KEGG 2.874E-8 1.027E-7 5.325E-7 2.874E-6 5 75
29 552665 Morphine addiction BioSystems: KEGG 7.654E-8 2.639E-7 1.369E-6 7.654E-6 5 91
30 P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PantherDB 2.078E-7 6.928E-7 3.594E-6 2.078E-5 5 111
31 217716 Cholinergic synapse BioSystems: KEGG 2.174E-7 7.013E-7 3.638E-6 2.174E-5 5 112
32 P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway PantherDB 5.128E-7 1.603E-6 8.314E-6 5.128E-5 4 53
33 P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PantherDB 9.320E-7 2.824E-6 1.465E-5 9.320E-5 5 150
34 1339116 Phase 4 - resting membrane potential BioSystems: REACTOME 1.667E-6 4.902E-6 2.543E-5 1.667E-4 3 19
35 M2701 Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. MSigDB C2 BIOCARTA (v6.0) 4.999E-6 1.428E-5 7.409E-5 4.999E-4 3 27
36 698773 Circadian entrainment BioSystems: KEGG 5.628E-6 1.563E-5 8.109E-5 5.628E-4 4 96
37 799177 Estrogen signaling pathway BioSystems: KEGG 6.110E-6 1.651E-5 8.566E-5 6.110E-4 4 98
38 537443 Retrograde endocannabinoid signaling BioSystems: KEGG 6.890E-6 1.813E-5 9.406E-5 6.890E-4 4 101
39 525336 Serotonergic synapse BioSystems: KEGG 1.077E-5 2.760E-5 1.432E-4 1.077E-3 4 113
40 M18342 G alpha i Pathway MSigDB C2 BIOCARTA (v6.0) 1.112E-5 2.779E-5 1.442E-4 1.112E-3 3 35
41 M19043 Adrenergic Pathway MSigDB C2 BIOCARTA (v6.0) 1.212E-5 2.955E-5 1.533E-4 1.212E-3 3 36
42 469199 Dopaminergic synapse BioSystems: KEGG 1.874E-5 4.463E-5 2.315E-4 1.874E-3 4 130
43 1339115 Cardiac conduction BioSystems: REACTOME 2.654E-5 6.172E-5 3.202E-4 2.654E-3 4 142
44 1269868 Muscle contraction BioSystems: REACTOME 1.092E-4 2.481E-4 1.287E-3 1.092E-2 4 204
45 1268772 Dopamine Neurotransmitter Release Cycle BioSystems: REACTOME 3.856E-4 8.570E-4 4.446E-3 3.856E-2 2 23
46 130626 Aldosterone-regulated sodium reabsorption BioSystems: KEGG 1.005E-3 2.184E-3 1.133E-2
1.005E-1
 2 37
47 1268768 Neurotransmitter Release Cycle BioSystems: REACTOME 1.903E-3 4.049E-3 2.100E-2
1.903E-1
 2 51
48 1427850 Interactions of neurexins and neuroligins at synapses BioSystems: REACTOME 2.539E-3 5.137E-3 2.665E-2
2.539E-1
 2 59
49 PW:0000677 altered insulin secretion pathway Pathway Ontology 2.569E-3 5.137E-3 2.665E-2
2.569E-1
 1 2
50 1339134 Defective ABCC8 can cause hypoglycemias and hyperglycemias BioSystems: REACTOME 2.569E-3 5.137E-3 2.665E-2
2.569E-1
 1 2
Show 45 more annotations

8: Pubmed [Display Chart] 16 input genes in category / 2072 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16382105 International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. Pubmed 4.123E-41 8.543E-38 7.017E-37 8.543E-38 12 15
2 18391953 Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Pubmed 5.856E-38 6.067E-35 4.983E-34 1.213E-34 12 22
3 17185339 Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins. Pubmed 1.437E-29 9.924E-27 8.151E-26 2.977E-26 10 25
4 16985003 Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Pubmed 3.610E-24 1.870E-21 1.536E-20 7.479E-21 11 137
5 7926018 Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. Pubmed 6.451E-18 2.228E-15 1.830E-14 1.337E-14 5 5
6 7580148 The inward rectifier potassium channel family. Pubmed 6.451E-18 2.228E-15 1.830E-14 1.337E-14 5 5
7 16109170 Expression of G-protein inwardly rectifying potassium channels (GIRKs) in lung cancer cell lines. Pubmed 2.053E-14 3.545E-12 2.912E-11 4.254E-11 4 4
8 7499385 Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. Pubmed 2.053E-14 3.545E-12 2.912E-11 4.254E-11 4 4
9 8630252 Functional analysis of the weaver mutant GIRK2 K+ channel and rescue of weaver granule cells. Pubmed 2.053E-14 3.545E-12 2.912E-11 4.254E-11 4 4
10 11891065 Structural characterization of the mouse Girk genes. Pubmed 2.053E-14 3.545E-12 2.912E-11 4.254E-11 4 4
11 10659995 Co-expression of human Kir3 subunits can yield channels with different functional properties. Pubmed 2.053E-14 3.545E-12 2.912E-11 4.254E-11 4 4
12 18088366 Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum. Pubmed 2.053E-14 3.545E-12 2.912E-11 4.254E-11 4 4
13 15024025 Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. Pubmed 7.477E-14 1.192E-11 9.788E-11 1.549E-10 5 19
14 19558451 Subcellular compartment-specific molecular diversity of pre- and post-synaptic GABA-activated GIRK channels in Purkinje cells. Pubmed 1.026E-13 1.418E-11 1.164E-10 2.127E-10 4 5
15 28464250 Regulation of Histone Acetylation on Expression Profiles of Potassium Channels During Cardiomyocyte Differentiation From Mouse Embryonic Stem Cells. Pubmed 1.026E-13 1.418E-11 1.164E-10 2.127E-10 4 5
16 14960569 A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. Pubmed 2.584E-12 3.149E-10 2.587E-9 5.353E-9 4 9
17 12297500 G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. Pubmed 2.584E-12 3.149E-10 2.587E-9 5.353E-9 4 9
18 10479680 Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. Pubmed 2.795E-11 3.217E-9 2.642E-8 5.791E-8 4 15
19 16339040 Molecular and cellular diversity of neuronal G-protein-gated potassium channels. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
20 16258766 Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
21 21637918 Identification of GIRK2-4 subunits in human esophageal smooth muscle cells. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
22 20798526 Functional characterization of inward rectifier potassium ion channel in murine fetal ventricular cardiomyocytes. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
23 7702616 Molecular cloning of a mouse G-protein-activated K+ channel (mGIRK1) and distinct distributions of three GIRK (GIRK1, 2 and 3) mRNAs in mouse brain. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
24 12034888 A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
25 15028774 Spinal G-protein-gated K+ channels formed by GIRK1 and GIRK2 subunits modulate thermal nociception and contribute to morphine analgesia. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
26 18194467 Behavioral characterization of mice lacking GIRK/Kir3 channel subunits. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
27 12032359 Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
28 12499858 Hyperalgesia and blunted morphine analgesia in G protein-gated potassium channel subunit knockout mice. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
29 16373386 Differential polyamine sensitivity in inwardly rectifying Kir2 potassium channels. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
30 9459542 Developmental expression of the GIRK family of inward rectifying potassium channels: implications for abnormalities in the weaver mutant mouse. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
31 20557431 Altered neurotransmission in the mesolimbic reward system of Girk mice. Pubmed 6.031E-11 4.031E-9 3.311E-8 1.250E-7 3 3
32 15142872 Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. Pubmed 2.412E-10 1.514E-8 1.244E-7 4.998E-7 3 4
33 15958527 Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. Pubmed 2.412E-10 1.514E-8 1.244E-7 4.998E-7 3 4
34 19135528 Intracellular trafficking and assembly of specific Kir3 channel/G protein complexes. Pubmed 6.028E-10 3.470E-8 2.850E-7 1.249E-6 3 5
35 11181181 Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. Pubmed 6.028E-10 3.470E-8 2.850E-7 1.249E-6 3 5
36 9108307 Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. Pubmed 6.028E-10 3.470E-8 2.850E-7 1.249E-6 3 5
37 17965710 RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Pubmed 1.205E-9 6.750E-8 5.544E-7 2.498E-6 3 6
38 21511879 PITX2 insufficiency leads to atrial electrical and structural remodeling linked to arrhythmogenesis. Pubmed 3.366E-8 1.836E-6 1.508E-5 6.975E-5 3 16
39 17473172 Tbx3 controls the sinoatrial node gene program and imposes pacemaker function on the atria. Pubmed 1.559E-7 3.589E-6 2.948E-5 3.230E-4 3 26
40 20921230 Direct and specific activation of human inward rectifier K+ channels by membrane phosphatidylinositol 4,5-bisphosphate. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
41 8929423 Heteromultimerization of G-protein-gated inwardly rectifying K+ channel proteins GIRK1 and GIRK2 and their altered expression in weaver brain. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
42 24193250 KCNJ10 mutations display differential sensitivity to heteromerisation with KCNJ16. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
43 23986512 Direct inhibition of basolateral Kir4.1/5.1 and Kir4.1 channels in the cortical collecting duct by dopamine. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
44 17122050 Distinct populations of spinal cord lamina II interneurons expressing G-protein-gated potassium channels. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
45 12456399 Identification of domains that control the heteromeric assembly of Kir5.1/Kir4.0 potassium channels. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
46 18702733 Pre- and postsynaptic regulation of locus coeruleus neurons after chronic morphine treatment: a study of GIRK-knockout mice. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
47 25612510 Molecular insights into the possible role of Kir4.1 and Kir5.1 in thyroid hormone biosynthesis. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
48 30304693 Association study between inwardly rectifying potassium channels 2.1 and 4.1 and autism spectrum disorders. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
49 15467839 Differential subunit composition of the G protein-activated inward-rectifier potassium channel during cardiac development. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
50 12086641 Alterations in conserved Kir channel-PIP2 interactions underlie channelopathies. Pubmed 1.645E-7 3.589E-6 2.948E-5 3.409E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 16 input genes in category / 236 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:KCNJ16 KCNJ16 interactions 2.223E-12 3.799E-10 2.296E-9 5.247E-10 4 5
2 int:DLG1 DLG1 interactions 3.220E-12 3.799E-10 2.296E-9 7.598E-10 7 110
3 int:KCNJ3 KCNJ3 interactions 5.590E-11 4.398E-9 2.658E-8 1.319E-8 4 9
4 int:KCNJ4 KCNJ4 interactions 6.036E-10 2.849E-8 1.722E-7 1.425E-7 4 15
5 int:KCNJ2 KCNJ2 interactions 6.036E-10 2.849E-8 1.722E-7 1.425E-7 4 15
6 int:DLG4 DLG4 interactions 2.002E-9 7.873E-8 4.758E-7 4.724E-7 7 274
7 int:PATJ PATJ interactions 5.371E-9 1.811E-7 1.094E-6 1.268E-6 5 76
8 int:KCNJ9 KCNJ9 interactions 1.209E-8 3.568E-7 2.156E-6 2.854E-6 3 6
9 int:DRD2 DRD2 interactions 2.575E-8 6.753E-7 4.081E-6 6.078E-6 4 36
10 int:IL16 IL16 interactions 4.416E-8 1.023E-6 6.182E-6 1.042E-5 4 41
11 int:CASK CASK interactions 4.768E-8 1.023E-6 6.182E-6 1.125E-5 5 117
12 int:DLG2 DLG2 interactions 1.269E-7 2.495E-6 1.508E-5 2.994E-5 4 53
13 int:DRD4 DRD4 interactions 1.723E-7 3.128E-6 1.890E-5 4.066E-5 3 13
14 int:LIN7B LIN7B interactions 3.368E-7 5.299E-6 3.202E-5 7.948E-5 3 16
15 int:KCNJ6 KCNJ6 interactions 3.368E-7 5.299E-6 3.202E-5 7.948E-5 3 16
16 int:KCNJ12 KCNJ12 interactions 4.902E-7 7.230E-6 4.369E-5 1.157E-4 3 18
17 int:DLG3 DLG3 interactions 8.219E-7 1.141E-5 6.895E-5 1.940E-4 4 84
18 int:SNTA1 SNTA1 interactions 1.134E-6 1.487E-5 8.986E-5 2.677E-4 4 91
19 int:ADRB2 ADRB2 interactions 2.516E-6 3.125E-5 1.889E-4 5.938E-4 5 260
20 int:LIN7A LIN7A interactions 5.012E-6 5.914E-5 3.574E-4 1.183E-3 3 38
21 int:PXDC1 PXDC1 interactions 7.646E-6 8.202E-5 4.957E-4 1.805E-3 2 5
22 int:KCNJ15 KCNJ15 interactions 7.646E-6 8.202E-5 4.957E-4 1.805E-3 2 5
23 int:MPP6 MPP6 interactions 1.157E-5 1.187E-4 7.173E-4 2.730E-3 3 50
24 int:LIN7C LIN7C interactions 1.461E-5 1.436E-4 8.681E-4 3.447E-3 3 54
25 int:KCNJ1 KCNJ1 interactions 3.432E-5 3.240E-4 1.958E-3 8.099E-3 2 10
26 int:P2RY1 P2RY1 interactions 4.192E-5 3.805E-4 2.300E-3 9.894E-3 2 11
27 int:MPP7 MPP7 interactions 5.028E-5 4.395E-4 2.656E-3 1.187E-2 2 12
28 int:KCNJ5 KCNJ5 interactions 1.033E-4 8.409E-4 5.082E-3 2.439E-2 2 17
29 int:KCNJ11 KCNJ11 interactions 1.033E-4 8.409E-4 5.082E-3 2.439E-2 2 17
30 int:MPP2 MPP2 interactions 1.751E-4 1.370E-3 8.282E-3 4.131E-2 2 22
31 int:PPFIA2 PPFIA2 interactions 1.916E-4 1.370E-3 8.282E-3 4.522E-2 2 23
32 int:KCNJ8 KCNJ8 interactions 1.916E-4 1.370E-3 8.282E-3 4.522E-2 2 23
33 int:APBA1 APBA1 interactions 1.916E-4 1.370E-3 8.282E-3 4.522E-2 2 23
34 int:KCNJ10 KCNJ10 interactions 2.458E-4 1.706E-3 1.031E-2
5.800E-2
 2 26
35 int:SLC20A1 SLC20A1 interactions 3.065E-4 2.067E-3 1.249E-2
7.234E-2
 2 29
36 int:DLGAP1 DLGAP1 interactions 4.219E-4 2.765E-3 1.671E-2
9.956E-2
 3 167
37 int:MPP5 MPP5 interactions 5.007E-4 3.194E-3 1.930E-2
1.182E-1
 2 37
38 int:MPP3 MPP3 interactions 6.152E-4 3.821E-3 2.309E-2
1.452E-1
 2 41
39 int:MPDZ MPDZ interactions 7.086E-4 4.181E-3 2.527E-2
1.672E-1
 2 44
40 int:SNTB2 SNTB2 interactions 7.086E-4 4.181E-3 2.527E-2
1.672E-1
 2 44
41 int:WWTR1 WWTR1 interactions 7.412E-4 4.266E-3 2.578E-2
1.749E-1
 2 45
42 int:ABCA1 ABCA1 interactions 9.147E-4 5.140E-3 3.106E-2
2.159E-1
 2 50
43 int:EPB41L2 EPB41L2 interactions 1.359E-3 7.456E-3 4.506E-2
3.206E-1
 2 61
44 int:SGK1 SGK1 interactions 1.784E-3 9.358E-3
5.655E-2
4.211E-1
 2 70
45 int:DMD DMD interactions 1.784E-3 9.358E-3
5.655E-2
4.211E-1
 2 70
46 int:ABLIM1 ABLIM1 interactions 2.557E-3 1.284E-2
7.759E-2
6.034E-1
 2 84
47 int:BAIAP2 BAIAP2 interactions 2.557E-3 1.284E-2
7.759E-2
6.034E-1
 2 84
48 int:SLC26A3 SLC26A3 interactions 2.709E-3 1.319E-2
7.974E-2
6.393E-1
 1 3
49 int:SLC9A3R2 SLC9A3R2 interactions 2.740E-3 1.319E-2
7.974E-2
6.465E-1
 2 87
50 int:NSUN2 NSUN2 interactions 3.324E-3 1.569E-2
9.480E-2
7.844E-1
 2 96
Show 45 more annotations

10: Cytoband [Display Chart] 16 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11q24 11q24 2.706E-5 2.210E-4 7.029E-4 3.518E-4 2 17
2 17q24.3 17q24.3 3.401E-5 2.210E-4 7.029E-4 4.421E-4 2 19
3 1q23.2 1q23.2 1.247E-4 5.404E-4 1.719E-3 1.621E-3 2 36
4 11p14 11p14 1.845E-3 5.997E-3 1.907E-2 2.399E-2 1 4
5 12q21 12q21 6.444E-3 1.676E-2
5.328E-2
8.378E-2
 1 14
6 2q24.1 2q24.1 1.285E-2 2.784E-2
8.854E-2
1.670E-1
 1 28
7 21q22.2 21q22.2 1.604E-2 2.902E-2
9.227E-2
2.085E-1
 1 35
8 21q22.1 21q22.1 1.786E-2 2.902E-2
9.227E-2
2.321E-1
 1 39
9 11p15.1 11p15.1 2.825E-2 4.080E-2
1.297E-1
3.672E-1
 1 62
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 15 input genes in category / 115 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 16 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 276 Potassium voltage-gated channel subfamily J genenames.org 1.209E-36 4.838E-36 1.008E-35 4.838E-36 12 16
2 1223 Crumbs complex genenames.org 2.601E-5 5.202E-5 1.084E-4 1.040E-4 2 9
3 1220 Membrane associated guanylate kinases|PDZ domain containing genenames.org 2.956E-4 3.941E-4 8.211E-4 1.182E-3 3 152
4 211 Adenosine receptors genenames.org 3.513E-3 3.513E-3 7.319E-3 1.405E-2 1 4

13: Coexpression [Display Chart] 16 input genes in category / 813 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19658189-TableS8d Human EmbryonicStemCell Xu09 85genes GeneSigDB 2.226E-9 1.810E-6 1.317E-5 1.810E-6 5 83
2 M2786 Genes down-regulated upon knockdown of PTEN [Gene ID=5728] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 2.609E-4 3.809E-2
2.772E-1
2.121E-1
 3 185
3 M8394 Genes up-regulated in dendritic cells: spleen CD8- versus brain. MSigDB C7: Immunologic Signatures (v6.0) 3.045E-4 3.809E-2
2.772E-1
2.475E-1
 3 195
4 M8400 Genes down-regulated in brain microglia versus spleen CD8- dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 3.184E-4 3.809E-2
2.772E-1
2.589E-1
 3 198
5 M7718 Genes up-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 0h versus 1h. MSigDB C7: Immunologic Signatures (v6.0) 3.231E-4 3.809E-2
2.772E-1
2.627E-1
 3 199
6 M4923 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from TIV influenza vaccinee pre-vaccination versus those post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 3.231E-4 3.809E-2
2.772E-1
2.627E-1
 3 199
7 M4351 Genes up-regulated in comparson of lung tissue from wild type mice subjected to ozone for 6 h vs that from TLR4 [GeneID=7099] deficient animal subjected to ozone for 6 h. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.809E-2
2.772E-1
2.666E-1
 3 200
Show 2 more annotations

14: Coexpression Atlas [Display Chart] 16 input genes in category / 1162 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap 2.808E-9 1.632E-6 1.246E-5 3.263E-6 6 188
2 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap 2.808E-9 1.632E-6 1.246E-5 3.263E-6 6 188
3 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes 6.954E-8 2.023E-5 1.545E-4 8.080E-5 6 322
4 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6 Top 200 Genes BrainMap 9.931E-8 2.023E-5 1.545E-4 1.154E-4 6 342
5 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6,Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a6,Slc17a7 Top 200 Genes BrainMap 1.010E-7 2.023E-5 1.545E-4 1.174E-4 6 343
6 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Overall Top 200 Genes BrainMap 1.817E-7 2.023E-5 1.545E-4 2.111E-4 5 188
7 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Overall Top 200 Genes BrainMap 1.817E-7 2.023E-5 1.545E-4 2.111E-4 5 188
8 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Overall Top 200 Genes BrainMap 1.866E-7 2.023E-5 1.545E-4 2.168E-4 5 189
9 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Top 200 BrainMap 1.866E-7 2.023E-5 1.545E-4 2.168E-4 5 189
10 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Overall Top 200 Genes BrainMap 1.866E-7 2.023E-5 1.545E-4 2.168E-4 5 189
11 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Overall Top 200 Genes BrainMap 1.915E-7 2.023E-5 1.545E-4 2.225E-4 5 190
12 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup7 Top 200 Genes BrainMap 3.965E-7 3.790E-5 2.894E-4 4.607E-4 5 220
13 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup2 Top 200 Genes BrainMap 4.240E-7 3.790E-5 2.894E-4 4.927E-4 5 223
14 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Fos Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Fos Top 200 Genes BrainMap 9.758E-7 7.559E-5 5.772E-4 1.134E-3 5 264
15 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap 9.758E-7 7.559E-5 5.772E-4 1.134E-3 5 264
16 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup6 Top 200 Genes BrainMap 1.130E-6 8.010E-5 6.116E-4 1.313E-3 5 272
17 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup4 Top 200 Genes BrainMap 1.172E-6 8.010E-5 6.116E-4 1.362E-3 5 274
18 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup3 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup3 Top 200 Genes BrainMap 1.374E-6 8.868E-5 6.771E-4 1.596E-3 5 283
19 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap 1.602E-6 9.004E-5 6.875E-4 1.862E-3 5 292
20 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Slc24a2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Syt6,Slc24a2 Top 200 Genes BrainMap 1.713E-6 9.004E-5 6.875E-4 1.990E-3 5 296
21 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 PosteriorCortex Top 200 Genes BrainMap 1.713E-6 9.004E-5 6.875E-4 1.990E-3 5 296
22 gudmap kidney adult RenalCortexMixed Std k2 200 kidney adult RenalCortexMixed Std k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.739E-6 9.004E-5 6.875E-4 2.021E-3 3 33
23 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap 1.860E-6 9.004E-5 6.875E-4 2.161E-3 5 301
24 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes 1.860E-6 9.004E-5 6.875E-4 2.161E-3 5 301
25 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a8 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a8 Top 200 Genes BrainMap 2.082E-6 9.675E-5 7.387E-4 2.419E-3 5 308
26 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap 2.217E-6 9.694E-5 7.402E-4 2.577E-3 5 312
27 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7 Top 200 Genes BrainMap 2.252E-6 9.694E-5 7.402E-4 2.617E-3 5 313
28 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Parm1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Subtype Neuron.excitatory.Slc17a7.Parm1 Top 200 Genes BrainMap 2.510E-6 1.042E-4 7.954E-4 2.917E-3 5 320
29 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 PosteriorCortex Top 200 Genes BrainMap 2.791E-6 1.118E-4 8.538E-4 3.243E-3 5 327
30 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Neuron.excitatory.Slc17a7,Slc17a6 Top 200 Genes BrainMap 3.475E-6 1.283E-4 9.799E-4 4.038E-3 5 342
31 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Subtype Excitatory.subGroup5 FrontalCortex Top 200 Genes BrainMap 3.575E-6 1.283E-4 9.799E-4 4.154E-3 5 344
32 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Subtype Excitatory.subGroup4 Hippocampus Top 200 Genes BrainMap 3.626E-6 1.283E-4 9.799E-4 4.214E-3 5 345
33 gudmap kidney adult JuxtaGlom Ren1 Captopr k4 200 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 3.645E-6 1.283E-4 9.799E-4 4.235E-3 3 42
34 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 FrontalCortex Top 200 Genes BrainMap 4.055E-6 1.386E-4 1.058E-3 4.712E-3 5 353
35 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 Hippocampus Top 200 Genes BrainMap 4.524E-6 1.502E-4 1.147E-3 5.257E-3 5 361
36 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes Oligodendrocyte.Pdgfa-hi oligodendrocytes Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tnf Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes Oligodendrocyte.Pdgfa-hi oligodendrocytes Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tnf Top 200 Genes BrainMap 4.968E-6 1.603E-4 1.224E-3 5.772E-3 5 368
37 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Subtype Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr PosteriorCortex Top 200 Genes BrainMap 5.168E-6 1.623E-4 1.239E-3 6.005E-3 5 371
38 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6 Sample Type by Project: Shred 1/TCGA-Kidney/Renal Cell Carcinoma/Kidney Chromophobe/6 TCGA-Kidney 7.367E-6 2.253E-4 1.720E-3 8.561E-3 4 179
39 BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll PosteriorCortex PosteriorCortex Overall Top 200 Genes BrainMap 8.393E-6 2.501E-4 1.909E-3 9.753E-3 4 185
40 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Overall Top 200 Genes BrainMap 8.944E-6 2.535E-4 1.935E-3 1.039E-2 4 188
41 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Top 200 BrainMap 8.944E-6 2.535E-4 1.935E-3 1.039E-2 4 188
42 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/FrontalCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gkn3/Endothelial Stalk.Flt1.Gkn3/FrontalCortex BrainMap 9.325E-6 2.567E-4 1.960E-3 1.084E-2 4 190
43 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup4 Excitatory.subGroup4 Overall Top 200 Genes BrainMap 9.521E-6 2.567E-4 1.960E-3 1.106E-2 4 191
44 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory BrainMap 9.719E-6 2.567E-4 1.960E-3 1.129E-2 4 192
45 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup5 Excitatory.subGroup5 Top 200 BrainMap 1.209E-5 3.121E-4 2.383E-3 1.405E-2 5 442
46 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Top 200 BrainMap BrainAtlas - Mouse McCarroll Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Oligodendrocyte.Pdgfa-hi oligodendrocytes.Tfr Top 200 BrainMap 1.466E-5 3.703E-4 2.827E-3 1.703E-2 5 460
47 BM Top 100 - kidney medulla BM Top 100 - kidney medulla Body Map 2.029E-5 5.016E-4 3.830E-3 2.358E-2 3 74
48 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Top 200 BrainMap 2.128E-5 5.151E-4 3.933E-3 2.473E-2 5 497
49 gudmap kidney adult JuxtaGlom Ren1 k1 200 kidney adult JuxtaGlom Ren1 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.198E-5 5.213E-4 3.980E-3 2.554E-2 3 76
50 gudmap kidney adult RenalCortexMixed Std k1 100 kidney adult RenalCortexMixed Std k-means-cluster#1 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 6.008E-5 1.396E-3 1.066E-2
6.982E-2
 2 16
Show 45 more annotations

15: Computational [Display Chart] 14 input genes in category / 47 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M785 MODULE 316 Ion channels. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.658E-10 1.249E-8 5.544E-8 1.249E-8 6 70

16: MicroRNA [Display Chart] 16 input genes in category / 597 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-365b-3p:TargetScan hsa-miR-365b-3p TargetScan 3.275E-5 9.777E-3
6.815E-2
 1.955E-2 3 285
2 hsa-miR-365a-3p:TargetScan hsa-miR-365a-3p TargetScan 3.275E-5 9.777E-3
6.815E-2
 1.955E-2 3 285
3 hsa-miR-6749-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.111E-5 1.589E-2
1.108E-1
 4.842E-2 3 387
4 hsa-miR-103-as:mirSVR highEffct hsa-miR-103-as:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.333E-4 1.589E-2
1.108E-1
7.960E-2
 3 458
5 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 1.597E-4 1.589E-2
1.108E-1
9.536E-2
 3 487
6 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 1.597E-4 1.589E-2
1.108E-1
9.536E-2
 3 487
7 hsa-miR-5189-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.986E-4 1.677E-2
1.169E-1
1.186E-1
 2 94
8 hsa-miR-7850-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.248E-4 1.677E-2
1.169E-1
1.342E-1
 2 100
9 hsa-miR-5196-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.508E-4 1.984E-2
1.383E-1
2.094E-1
 2 125
10 hsa-miR-770-5p:PITA hsa-miR-770-5p:PITA TOP PITA 4.149E-4 1.984E-2
1.383E-1
2.477E-1
 2 136
11 hsa-miR-362-5p:PITA hsa-miR-362-5p:PITA TOP PITA 4.149E-4 1.984E-2
1.383E-1
2.477E-1
 2 136
12 hsa-miR-1224-5p:TargetScan hsa-miR-1224-5p TargetScan 5.176E-4 1.984E-2
1.383E-1
3.090E-1
 2 152
13 GACTGTT,MIR-212:MSigDB GACTGTT,MIR-212:MSigDB MSigDB 5.313E-4 1.984E-2
1.383E-1
3.172E-1
 2 154
14 GACTGTT,MIR-132:MSigDB GACTGTT,MIR-132:MSigDB MSigDB 5.313E-4 1.984E-2
1.383E-1
3.172E-1
 2 154
15 hsa-miR-3190-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.451E-4 1.984E-2
1.383E-1
3.254E-1
 2 156
16 hsa-miR-190b:TargetScan hsa-miR-190b TargetScan 6.240E-4 1.984E-2
1.383E-1
3.725E-1
 2 167
17 hsa-miR-190a-5p:TargetScan hsa-miR-190a-5p TargetScan 6.240E-4 1.984E-2
1.383E-1
3.725E-1
 2 167
18 hsa-miR-5088-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.240E-4 1.984E-2
1.383E-1
3.725E-1
 2 167
19 hsa-miR-365:PITA hsa-miR-365:PITA TOP PITA 6.314E-4 1.984E-2
1.383E-1
3.770E-1
 2 168
20 hsa-miR-585:mirSVR lowEffct hsa-miR-585:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.482E-4 2.040E-2
1.422E-1
4.466E-1
 2 183
21 hsa-miR-455-5p:TargetScan hsa-miR-455-5p TargetScan 7.727E-4 2.040E-2
1.422E-1
4.613E-1
 2 186
22 hsa-miR-297:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.059E-4 2.040E-2
1.422E-1
4.811E-1
 2 190
23 hsa-miR-567:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.143E-4 2.040E-2
1.422E-1
4.862E-1
 2 191
24 hsa-miR-489:PITA hsa-miR-489:PITA TOP PITA 8.228E-4 2.040E-2
1.422E-1
4.912E-1
 2 192
25 hsa-miR-3646:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.921E-4 2.040E-2
1.422E-1
5.326E-1
 2 200
26 hsa-miR-425-5p:TargetScan hsa-miR-425-5p TargetScan 9.098E-4 2.040E-2
1.422E-1
5.432E-1
 2 202
27 hsa-miR-649:PITA hsa-miR-649:PITA TOP PITA 1.010E-3 2.040E-2
1.422E-1
6.032E-1
 2 213
28 hsa-miR-411-3p:TargetScan hsa-miR-411-3p TargetScan 1.020E-3 2.040E-2
1.422E-1
6.088E-1
 2 214
29 hsa-miR-379-3p:TargetScan hsa-miR-379-3p TargetScan 1.020E-3 2.040E-2
1.422E-1
6.088E-1
 2 214
30 hsa-miR-4698:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.039E-3 2.040E-2
1.422E-1
6.201E-1
 2 216
31 hsa-miR-651-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.126E-3 2.040E-2
1.422E-1
6.722E-1
 2 225
32 hsa-miR-3667-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.126E-3 2.040E-2
1.422E-1
6.722E-1
 2 225
33 hsa-miR-4691-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.186E-3 2.040E-2
1.422E-1
7.081E-1
 2 231
34 hsa-miR-6792-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.196E-3 2.040E-2
1.422E-1
7.142E-1
 2 232
35 hsa-miR-1261:PITA hsa-miR-1261:PITA TOP PITA 1.196E-3 2.040E-2
1.422E-1
7.142E-1
 2 232
36 hsa-miR-6771-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.441E-3 2.344E-2
1.634E-1
8.606E-1
 2 255
37 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 1.453E-3 2.344E-2
1.634E-1
8.672E-1
 2 256
38 hsa-miR-511-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.509E-3 2.371E-2
1.652E-1
9.009E-1
 2 261
39 hsa-miR-505-3p.2:TargetScan hsa-miR-505-3p.2 TargetScan 1.578E-3 2.373E-2
1.654E-1
9.422E-1
 2 267
40 hsa-miR-891b:PITA hsa-miR-891b:PITA TOP PITA 1.590E-3 2.373E-2
1.654E-1
9.491E-1
 2 268
41 hsa-miR-606:PITA hsa-miR-606:PITA TOP PITA 1.998E-3 2.909E-2
2.028E-1
1.000E0
 2 301
42 hsa-miR-6817-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.294E-3 3.120E-2
2.175E-1
1.000E0
 2 323
43 hsa-miR-194-5p:TargetScan hsa-miR-194-5p TargetScan 2.393E-3 3.120E-2
2.175E-1
1.000E0
 2 330
44 hsa-miR-421:TargetScan hsa-miR-421 TargetScan 2.422E-3 3.120E-2
2.175E-1
1.000E0
 2 332
45 hsa-miR-219a-5p:TargetScan hsa-miR-219a-5p TargetScan 2.450E-3 3.120E-2
2.175E-1
1.000E0
 2 334
46 hsa-miR-212:PITA hsa-miR-212:PITA TOP PITA 2.508E-3 3.120E-2
2.175E-1
1.000E0
 2 338
47 hsa-miR-132:PITA hsa-miR-132:PITA TOP PITA 2.508E-3 3.120E-2
2.175E-1
1.000E0
 2 338
48 hsa-miR-8088:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.655E-3 3.120E-2
2.175E-1
1.000E0
 1 12
49 hsa-miR-7110-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.670E-3 3.120E-2
2.175E-1
1.000E0
 2 349
50 hsa-miR-9-5p:Functional MTI Functional MTI miRTarbase 2.685E-3 3.120E-2
2.175E-1
1.000E0
 2 350
Show 45 more annotations

17: Drug [Display Chart] 16 input genes in category / 4221 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005255110 CID5255110 Stitch 3.619E-26 1.528E-22 1.363E-21 1.528E-22 11 57
2 CID000062278 A13108 Stitch 3.154E-25 6.656E-22 5.941E-21 1.331E-21 8 10
3 CID000025157 barium chloride dihydrate Stitch 1.433E-24 2.016E-21 1.800E-20 6.049E-21 10 43
4 CID000004826 pinacidil Stitch 5.460E-24 5.222E-21 4.661E-20 2.305E-20 11 87
5 CID000104810 barium Stitch 6.186E-24 5.222E-21 4.661E-20 2.611E-20 12 148
6 CID000025204 BaCl2 Stitch 1.784E-23 1.255E-20 1.120E-19 7.530E-20 10 54
7 ctd:D011188 Potassium CTD 5.400E-23 3.256E-20 2.906E-19 2.279E-19 11 106
8 CID000105153 rubidium Stitch 6.711E-23 3.541E-20 3.160E-19 2.833E-19 10 61
9 CID011819083 1 sulfonylurea Stitch 1.665E-21 7.807E-19 6.968E-18 7.027E-18 11 143
10 CID000071191 cromakalim Stitch 3.337E-21 1.409E-18 1.257E-17 1.409E-17 10 88
11 CID009543520 triphosphoinositide Stitch 1.164E-20 4.465E-18 3.985E-17 4.911E-17 12 273
12 CID000002284 baclofen Stitch 4.402E-20 1.548E-17 1.382E-16 1.858E-16 11 191
13 CID000003019 diazoxide Stitch 3.062E-19 9.941E-17 8.872E-16 1.292E-15 11 227
14 CID000003488 glibenclamide Stitch 6.911E-19 2.084E-16 1.860E-15 2.917E-15 12 382
15 CID000001727 4-AP Stitch 1.282E-18 3.607E-16 3.219E-15 5.410E-15 11 258
16 CID000005413 tetraethylammonium Stitch 8.687E-17 2.292E-14 2.045E-13 3.667E-13 10 236
17 CID000061605 Rubidium chromate Stitch 1.035E-16 2.571E-14 2.295E-13 4.371E-13 8 74
18 CID000000768 cyanide Stitch 1.829E-16 4.289E-14 3.828E-13 7.720E-13 10 254
19 CID000002520 verapamil Stitch 1.572E-15 3.416E-13 3.049E-12 6.634E-12 11 490
20 CID004188587 methanethiosulfonate Stitch 1.619E-15 3.416E-13 3.049E-12 6.833E-12 8 103
21 CID000024587 Barium permanganate Stitch 1.321E-14 2.656E-12 2.371E-11 5.578E-11 8 133
22 CID000001103 spermine Stitch 1.521E-14 2.910E-12 2.597E-11 6.419E-11 10 394
23 CID000024293 CsCl Stitch 1.586E-14 2.910E-12 2.597E-11 6.694E-11 8 136
24 ctd:D001464 Barium CTD 2.563E-14 4.508E-12 4.023E-11 1.082E-10 7 72
25 CID000643998 GDP-b-S Stitch 6.936E-14 1.171E-11 1.045E-10 2.928E-10 8 163
26 CID000164531 H-8105 Stitch 5.776E-12 9.377E-10 8.369E-9 2.438E-8 8 282
27 CID000055480 milnacipran Stitch 1.190E-11 1.860E-9 1.660E-8 5.023E-8 5 30
28 CID000208951 bifeprunox Stitch 1.143E-10 1.724E-8 1.538E-7 4.826E-7 4 13
29 ctd:C110027 beta-apocarotenoid-14',13'-dioxygenase CTD 2.820E-10 4.105E-8 3.663E-7 1.190E-6 3 3
30 CID006432719 TlBr Stitch 1.128E-9 1.586E-7 1.416E-6 4.759E-6 3 4
31 ctd:D013793 Thallium CTD 1.165E-9 1.587E-7 1.416E-6 4.919E-6 4 22
32 CID000079091 1-chloro-1,2,2-trifluorocyclobutane Stitch 1.691E-9 2.231E-7 1.991E-6 7.140E-6 4 24
33 CID000005505 tolbutamide Stitch 2.930E-9 3.748E-7 3.345E-6 1.237E-5 6 198
34 CID000002245 doyle Stitch 3.196E-9 3.968E-7 3.541E-6 1.349E-5 5 88
35 CID000062677 KRS-5 Stitch 5.633E-9 6.508E-7 5.809E-6 2.378E-5 3 6
36 CID000017570 4,4'-thiodiphenol Stitch 5.705E-9 6.508E-7 5.809E-6 2.408E-5 4 32
37 CID000004452 YM-09151-2 Stitch 5.705E-9 6.508E-7 5.809E-6 2.408E-5 4 32
38 CID003058747 AC1MHW5N Stitch 9.329E-9 1.036E-6 9.249E-6 3.938E-5 4 36
39 CID000009643 1,2-dichlorohexafluorocyclobutane Stitch 1.046E-8 1.132E-6 1.010E-5 4.413E-5 4 37
40 CID005137129 beta-FNA Stitch 1.301E-8 1.373E-6 1.225E-5 5.492E-5 4 39
41 CID000002692 N6-cyclohexyladenosine Stitch 1.445E-8 1.488E-6 1.328E-5 6.099E-5 4 40
42 ctd:D000068736 Duloxetine Hydrochloride CTD 1.576E-8 1.547E-6 1.381E-5 6.652E-5 3 8
43 DB01016 Glyburide Drug Bank 1.576E-8 1.547E-6 1.381E-5 6.652E-5 3 8
44 CID000068930 5 beta-alphaxalone Stitch 1.768E-8 1.696E-6 1.514E-5 7.464E-5 4 42
45 ctd:D000657 Amoxapine CTD 2.363E-8 2.216E-6 1.978E-5 9.973E-5 3 9
46 CID000031328 AC1Q5QXZ Stitch 3.374E-8 3.096E-6 2.763E-5 1.424E-4 3 10
47 CID000026644 Revivon Stitch 4.971E-8 4.371E-6 3.901E-5 2.098E-4 4 54
48 CID000041987 NSC-305352 Stitch 4.971E-8 4.371E-6 3.901E-5 2.098E-4 4 54
49 CID000003668 HMS3267E16 Stitch 8.739E-8 7.528E-6 6.719E-5 3.689E-4 4 62
50 CID000071329 dofetilide Stitch 9.327E-8 7.874E-6 7.028E-5 3.937E-4 4 63
Show 45 more annotations

18: Disease [Display Chart] 15 input genes in category / 503 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1720983 Channelopathies DisGeNET BeFree 1.201E-9 6.039E-7 4.106E-6 6.039E-7 5 56
2 C0020621 Hypokalemia DisGeNET Curated 3.443E-6 8.659E-4 5.887E-3 1.732E-3 3 33
3 C1846348 Renal potassium wasting DisGeNET Curated 7.985E-6 1.004E-3 6.823E-3 4.016E-3 2 5
4 C0020428 Hyperaldosteronism DisGeNET Curated 9.510E-6 1.004E-3 6.823E-3 4.784E-3 3 46
5 C0740898 Hypokalemic metabolic alkalosis DisGeNET Curated 1.197E-5 1.004E-3 6.823E-3 6.021E-3 2 6
6 C2748572 SeSAME syndrome DisGeNET Curated 1.197E-5 1.004E-3 6.823E-3 6.021E-3 2 6
7 C0021670 insulinoma DisGeNET Curated 1.908E-5 1.371E-3 9.319E-3 9.595E-3 4 182
8 C1855852 Large eyes DisGeNET Curated 2.868E-5 1.418E-3 9.642E-3 1.443E-2 2 9
9 C4280603 Increased size of palpebral fissures DisGeNET Curated 2.868E-5 1.418E-3 9.642E-3 1.443E-2 2 9
10 C0240783 Elevated plasma renin DisGeNET Curated 2.868E-5 1.418E-3 9.642E-3 1.443E-2 2 9
11 C0023976 Long QT Syndrome DisGeNET Curated 3.102E-5 1.418E-3 9.642E-3 1.560E-2 3 68
12 C0020599 Hypocalciuria DisGeNET Curated 4.377E-5 1.835E-3 1.247E-2 2.202E-2 2 11
13 C0011175 Dehydration DisGeNET Curated 6.055E-5 2.343E-3 1.593E-2 3.046E-2 3 85
14 C0151878 Prolonged QT interval DisGeNET Curated 1.079E-4 3.877E-3 2.636E-2
5.427E-2
 2 17
15 C1846347 Renal salt wasting DisGeNET Curated 1.213E-4 4.068E-3 2.766E-2
6.102E-2
 2 18
16 C0423221 Globe of eye large DisGeNET Curated 1.505E-4 4.718E-3 3.208E-2
7.570E-2
 2 20
17 C1563715 Andersen Syndrome DisGeNET Curated 1.662E-4 4.718E-3 3.208E-2
8.362E-2
 2 21
18 C0027746 Nerve Degeneration DisGeNET Curated 1.689E-4 4.718E-3 3.208E-2
8.493E-2
 3 120
19 C0085602 Polydipsia DisGeNET Curated 2.370E-4 5.960E-3 4.052E-2
1.192E-1
 2 25
20 C4020868 Elevated heart rate DisGeNET Curated 2.370E-4 5.960E-3 4.052E-2
1.192E-1
 2 25
21 C0231246 Failure to gain weight DisGeNET Curated 2.898E-4 6.467E-3 4.397E-2
1.458E-1
 4 367
22 C0004775 Bartter Disease DisGeNET Curated 3.200E-4 6.467E-3 4.397E-2
1.610E-1
 2 29
23 C2315100 Pediatric failure to thrive DisGeNET Curated 3.410E-4 6.467E-3 4.397E-2
1.715E-1
 4 383
24 C0406810 Carney Complex DisGeNET Curated 3.662E-4 6.467E-3 4.397E-2
1.842E-1
 2 31
25 C0032617 Polyuria DisGeNET Curated 3.662E-4 6.467E-3 4.397E-2
1.842E-1
 2 31
26 C0039070 Syncope DisGeNET Curated 4.948E-4 6.467E-3 4.397E-2
2.489E-1
 2 36
27 C0014548 Epilepsy, Generalized DisGeNET Curated 5.515E-4 6.467E-3 4.397E-2
2.774E-1
 2 38
28 C0235480 Paroxysmal atrial fibrillation DisGeNET Curated 6.422E-4 6.467E-3 4.397E-2
3.231E-1
 2 41
29 C0039231 Tachycardia DisGeNET Curated 7.065E-4 6.467E-3 4.397E-2
3.554E-1
 2 43
30 C1865018 Short QT Syndrome 3 DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
31 C4280480 Increased size of frontal sinus DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
32 cv:C3151431 Atrial fibrillation, familial, 9 Clinical Variations 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
33 C1827973 Barbiturate withdrawal DisGeNET BeFree 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
34 OMIN:612780 SEIZURES, SENSORINEURAL DEAFNESS, ATAXIA, MENTAL RETARDATION, AND ELECTROLYTE IMBALANCE OMIM 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
35 C0240928 Salt craving DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
36 C2748576 Renal sodium wasting DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
37 C0426439 Narrow nostrils DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
38 cv:C2748572 SeSAME syndrome Clinical Variations 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
39 cv:C3150733 Long QT syndrome 13 Clinical Variations 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
40 cv:C1865018 Short QT syndrome 3 Clinical Variations 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
41 C4280481 Hypertrophy of frontal sinus DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
42 C3150733 LONG QT SYNDROME 13 DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
43 C3151431 ATRIAL FIBRILLATION, FAMILIAL, 9 DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
44 C4280265 Hyperplasia of frontal sinus DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
45 OMIN:610582 DIABETES MELLITUS, TRANSIENT NEONATAL, 3 OMIM 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
46 C2931833 Hyperinsulinemic hypoglycemia, familial, 2 DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
47 C4020742 Familial primary hyperaldosteronism type 2 DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
48 C3150933 HYPERALDOSTERONISM, FAMILIAL, TYPE III DisGeNET Curated 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
49 cv:C0027773 Islet cell hyperplasia Clinical Variations 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
50 cv:C1855849 Bartter syndrome antenatal type 2 Clinical Variations 9.256E-4 6.467E-3 4.397E-2
4.656E-1
 1 1
Show 45 more annotations