Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc123_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 10 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003684 damaged DNA binding 4.014E-7 4.014E-6 1.176E-5 4.014E-6 3 65
2 GO:0004842 ubiquitin-protein transferase activity 1.049E-4 4.218E-4 1.235E-3 1.049E-3 3 414
3 GO:0019787 ubiquitin-like protein transferase activity 1.265E-4 4.218E-4 1.235E-3 1.265E-3 3 441
4 GO:0061630 ubiquitin protein ligase activity 1.256E-3 2.631E-3 7.705E-3 1.256E-2 2 212
5 GO:0061659 ubiquitin-like protein ligase activity 1.315E-3 2.631E-3 7.705E-3 1.315E-2 2 217
6 GO:0031625 ubiquitin protein ligase binding 2.071E-3 3.045E-3 8.919E-3 2.071E-2 2 273
7 GO:0044389 ubiquitin-like protein ligase binding 2.132E-3 3.045E-3 8.919E-3 2.132E-2 2 277
8 GO:0004176 ATP-dependent peptidase activity 2.677E-3 3.346E-3 9.800E-3 2.677E-2 1 10
Show 3 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 120 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006293 nucleotide-excision repair, preincision complex stabilization 5.969E-12 2.649E-10 1.422E-9 7.162E-10 4 21
2 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion 5.969E-12 2.649E-10 1.422E-9 7.162E-10 4 21
3 GO:0000717 nucleotide-excision repair, DNA duplex unwinding 7.295E-12 2.649E-10 1.422E-9 8.754E-10 4 22
4 GO:0000715 nucleotide-excision repair, DNA damage recognition 8.830E-12 2.649E-10 1.422E-9 1.060E-9 4 23
5 GO:0006294 nucleotide-excision repair, preincision complex assembly 2.368E-11 5.683E-10 3.051E-9 2.841E-9 4 29
6 GO:0070911 global genome nucleotide-excision repair 3.584E-11 7.169E-10 3.849E-9 4.301E-9 4 32
7 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion 6.582E-11 1.128E-9 6.058E-9 7.898E-9 4 37
8 GO:0033683 nucleotide-excision repair, DNA incision 8.196E-11 1.229E-9 6.601E-9 9.835E-9 4 39
9 GO:0070914 UV-damage excision repair 1.114E-9 1.486E-8 7.977E-8 1.337E-7 3 10
10 GO:0032508 DNA duplex unwinding 1.276E-9 1.532E-8 8.224E-8 1.532E-7 4 76
11 GO:0032392 DNA geometric change 1.655E-9 1.805E-8 9.693E-8 1.986E-7 4 81
12 GO:0035518 histone H2A monoubiquitination 2.043E-9 2.043E-8 1.097E-7 2.451E-7 3 12
13 GO:0043254 regulation of protein complex assembly 4.461E-9 4.117E-8 2.211E-7 5.353E-7 5 400
14 GO:0006289 nucleotide-excision repair 7.886E-9 6.759E-8 3.629E-7 9.463E-7 4 119
15 GO:0033522 histone H2A ubiquitination 8.992E-9 7.193E-8 3.862E-7 1.079E-6 3 19
16 GO:0010390 histone monoubiquitination 1.643E-8 1.232E-7 6.615E-7 1.971E-6 3 23
17 GO:0042769 DNA damage response, detection of DNA damage 6.616E-8 4.670E-7 2.507E-6 7.940E-6 3 36
18 GO:0016574 histone ubiquitination 9.874E-8 6.491E-7 3.485E-6 1.185E-5 3 41
19 GO:0065004 protein-DNA complex assembly 1.028E-7 6.491E-7 3.485E-6 1.233E-5 4 225
20 GO:0031334 positive regulation of protein complex assembly 1.084E-7 6.503E-7 3.491E-6 1.301E-5 4 228
21 GO:0071824 protein-DNA complex subunit organization 1.620E-7 9.256E-7 4.970E-6 1.944E-5 4 252
22 GO:0090305 nucleic acid phosphodiester bond hydrolysis 2.201E-7 1.197E-6 6.429E-6 2.641E-5 4 272
23 GO:0006513 protein monoubiquitination 2.295E-7 1.197E-6 6.429E-6 2.754E-5 3 54
24 GO:0071103 DNA conformation change 2.654E-7 1.327E-6 7.123E-6 3.184E-5 4 285
25 GO:0006283 transcription-coupled nucleotide-excision repair 5.746E-7 2.652E-6 1.424E-5 6.895E-5 3 73
26 GO:0034644 cellular response to UV 5.746E-7 2.652E-6 1.424E-5 6.895E-5 3 73
27 GO:0044089 positive regulation of cellular component biogenesis 1.695E-6 7.532E-6 4.044E-5 2.034E-4 4 453
28 GO:0071482 cellular response to light stimulus 2.585E-6 1.108E-5 5.948E-5 3.102E-4 3 120
29 GO:0009411 response to UV 4.113E-6 1.702E-5 9.137E-5 4.935E-4 3 140
30 GO:0071478 cellular response to radiation 7.638E-6 3.055E-5 1.640E-4 9.165E-4 3 172
31 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle 2.174E-5 8.415E-5 4.518E-4 2.609E-3 2 28
32 GO:1902808 positive regulation of cell cycle G1/S phase transition 3.035E-5 1.138E-4 6.110E-4 3.642E-3 2 33
33 GO:0071214 cellular response to abiotic stimulus 4.371E-5 1.590E-4 8.534E-4 5.245E-3 3 308
34 GO:1901990 regulation of mitotic cell cycle phase transition 4.808E-5 1.697E-4 9.112E-4 5.770E-3 3 318
35 GO:0009416 response to light stimulus 5.717E-5 1.923E-4 1.032E-3 6.861E-3 3 337
36 GO:1901987 regulation of cell cycle phase transition 5.768E-5 1.923E-4 1.032E-3 6.921E-3 3 338
37 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 9.037E-5 2.931E-4 1.574E-3 1.084E-2 3 393
38 GO:1901992 positive regulation of mitotic cell cycle phase transition 1.049E-4 3.312E-4 1.778E-3 1.258E-2 2 61
39 GO:0010498 proteasomal protein catabolic process 1.117E-4 3.436E-4 1.845E-3 1.340E-2 3 422
40 GO:1901989 positive regulation of cell cycle phase transition 1.266E-4 3.799E-4 2.039E-3 1.519E-2 2 67
41 GO:0016570 histone modification 1.325E-4 3.878E-4 2.082E-3 1.590E-2 3 447
42 GO:0016569 covalent chromatin modification 1.462E-4 4.176E-4 2.242E-3 1.754E-2 3 462
43 GO:0009314 response to radiation 1.637E-4 4.569E-4 2.453E-3 1.965E-2 3 480
44 GO:0045931 positive regulation of mitotic cell cycle 4.917E-4 1.341E-3 7.200E-3
5.900E-2
 2 132
45 GO:2000045 regulation of G1/S transition of mitotic cell cycle 6.011E-4 1.603E-3 8.605E-3
7.213E-2
 2 146
46 GO:1902806 regulation of cell cycle G1/S phase transition 6.858E-4 1.789E-3 9.605E-3
8.229E-2
 2 156
47 GO:2000819 regulation of nucleotide-excision repair 8.053E-4 2.056E-3 1.104E-2
9.663E-2
 1 3
48 GO:0046726 positive regulation by virus of viral protein levels in host cell 1.074E-3 2.684E-3 1.441E-2
1.288E-1
 1 4
49 GO:0000082 G1/S transition of mitotic cell cycle 1.706E-3 4.179E-3 2.244E-2
2.048E-1
 2 247
50 GO:0044843 cell cycle G1/S phase transition 1.846E-3 4.334E-3 2.327E-2
2.215E-1
 2 257
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 8 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0080008 Cul4-RING E3 ubiquitin ligase complex 2.535E-15 2.028E-14 5.512E-14 2.028E-14 5 25
2 GO:0031461 cullin-RING ubiquitin ligase complex 3.226E-11 1.290E-10 3.507E-10 2.581E-10 5 154
3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex 8.664E-11 2.310E-10 6.279E-10 6.931E-10 3 5
4 GO:0000151 ubiquitin ligase complex 5.920E-10 1.164E-9 3.164E-9 4.736E-9 5 274
5 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex 7.275E-10 1.164E-9 3.164E-9 5.820E-9 3 9
6 GO:0000784 nuclear chromosome, telomeric region 3.441E-2 4.588E-2
1.247E-1
2.753E-1
 1 133
7 GO:0000781 chromosome, telomeric region 4.178E-2 4.775E-2
1.298E-1
3.343E-1
 1 162
Show 2 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 398 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 5 input genes in category / 221 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 5 input genes in category / 35 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00182 CULLIN SMART 1.196E-6 8.967E-6 3.718E-5 4.186E-5 2 7
2 IPR016157 Cullin CS InterPro 1.196E-6 8.967E-6 3.718E-5 4.186E-5 2 7
3 SM00884 Cullin Nedd8 SMART 1.595E-6 8.967E-6 3.718E-5 5.581E-5 2 8
4 PF10557 Cullin Nedd8 Pfam 1.595E-6 8.967E-6 3.718E-5 5.581E-5 2 8
5 IPR019559 Cullin neddylation domain InterPro 1.595E-6 8.967E-6 3.718E-5 5.581E-5 2 8
6 IPR016158 Cullin homology InterPro 2.050E-6 8.967E-6 3.718E-5 7.175E-5 2 9
7 IPR001373 Cullin N InterPro 2.562E-6 8.967E-6 3.718E-5 8.967E-5 2 10
8 PF00888 Cullin Pfam 2.562E-6 8.967E-6 3.718E-5 8.967E-5 2 10
9 PS01256 CULLIN 1 PROSITE 2.562E-6 8.967E-6 3.718E-5 8.967E-5 2 10
10 PS50069 CULLIN 2 PROSITE 2.562E-6 8.967E-6 3.718E-5 8.967E-5 2 10
11 IPR016159 Cullin repeat-like dom InterPro 3.757E-6 1.195E-5 4.957E-5 1.315E-4 2 12
12 IPR033044 CUL4B InterPro 2.669E-4 6.672E-4 2.767E-3 9.341E-3 1 1
13 PS51788 CULT PROSITE 2.669E-4 6.672E-4 2.767E-3 9.341E-3 1 1
14 IPR033312 DDB2 InterPro 2.669E-4 6.672E-4 2.767E-3 9.341E-3 1 1
15 IPR004871 Cleavage/polyA-sp fac asu C InterPro 8.005E-4 1.751E-3 7.261E-3 2.802E-2 1 3
16 PF03178 CPSF A Pfam 8.005E-4 1.751E-3 7.261E-3 2.802E-2 1 3
17 1.10.10.10 - Gene3D 1.317E-3 2.598E-3 1.077E-2 4.610E-2 2 218
18 PF02190 LON substr bdg Pfam 1.600E-3 2.598E-3 1.077E-2
5.601E-2
 1 6
19 IPR003111 LON substr-bd dom InterPro 1.600E-3 2.598E-3 1.077E-2
5.601E-2
 1 6
20 PS51787 LON N PROSITE 1.600E-3 2.598E-3 1.077E-2
5.601E-2
 1 6
21 SM00464 LON SMART 1.600E-3 2.598E-3 1.077E-2
5.601E-2
 1 6
22 IPR011991 WHTH DNA-bd dom InterPro 1.633E-3 2.598E-3 1.077E-2
5.715E-2
 2 243
23 PF03226 Yippee-Mis18 Pfam 2.133E-3 3.111E-3 1.290E-2
7.467E-2
 1 8
24 IPR004910 Yippee/Mis18/Cereblon InterPro 2.133E-3 3.111E-3 1.290E-2
7.467E-2
 1 8
25 IPR017986 WD40 repeat dom InterPro 2.427E-3 3.397E-3 1.409E-2
8.494E-2
 2 297
26 2.130.10.10 - Gene3D 3.040E-3 3.988E-3 1.654E-2
1.064E-1
 2 333
27 IPR015943 WD40/YVTN repeat-like dom InterPro 3.076E-3 3.988E-3 1.654E-2
1.077E-1
 2 335
28 IPR015947 PUA-like domain InterPro 5.061E-3 6.326E-3 2.623E-2
1.771E-1
 1 19
Show 23 more annotations

7: Pathway [Display Chart] 4 input genes in category / 23 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1309113 DNA Damage Recognition in GG-NER BioSystems: REACTOME 8.220E-11 9.456E-10 3.531E-9 1.891E-9 4 39
2 1309115 Dual Incision in GG-NER BioSystems: REACTOME 1.012E-10 9.456E-10 3.531E-9 2.328E-9 4 41
3 1309114 Formation of Incision Complex in GG-NER BioSystems: REACTOME 1.233E-10 9.456E-10 3.531E-9 2.837E-9 4 43
4 83044 Nucleotide excision repair BioSystems: KEGG 1.783E-10 1.025E-9 3.828E-9 4.100E-9 4 47
5 1309112 Global Genome Nucleotide Excision Repair (GG-NER) BioSystems: REACTOME 2.024E-9 9.309E-9 3.476E-8 4.654E-8 4 85
6 1309111 Nucleotide Excision Repair BioSystems: REACTOME 6.207E-9 2.379E-8 8.885E-8 1.428E-7 4 112
7 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 1.404E-8 4.612E-8 1.722E-7 3.228E-7 4 137
8 1270368 Recognition of DNA damage by PCNA-containing replication complex BioSystems: REACTOME 5.042E-8 1.450E-7 5.413E-7 1.160E-6 3 30
9 1270367 DNA Damage Bypass BioSystems: REACTOME 2.431E-7 6.213E-7 2.320E-6 5.592E-6 3 50
10 1309118 Formation of TC-NER Pre-Incision Complex BioSystems: REACTOME 3.076E-7 7.075E-7 2.642E-6 7.075E-6 3 54
11 1270350 DNA Repair BioSystems: REACTOME 4.232E-7 8.848E-7 3.304E-6 9.732E-6 4 319
12 1309120 Gap-filling DNA repair synthesis and ligation in TC-NER BioSystems: REACTOME 5.413E-7 1.003E-6 3.747E-6 1.245E-5 3 65
13 1309119 Dual incision in TC-NER BioSystems: REACTOME 5.671E-7 1.003E-6 3.747E-6 1.304E-5 3 66
14 1309117 Transcription-Coupled Nucleotide Excision Repair (TC-NER) BioSystems: REACTOME 9.792E-7 1.609E-6 6.007E-6 2.252E-5 3 79
15 694606 Hepatitis B BioSystems: KEGG 7.851E-4 1.204E-3 4.495E-3 1.806E-2 2 144
16 83055 p53 signaling pathway BioSystems: KEGG 2.199E-2 3.103E-2
1.159E-1
5.057E-1
 1 69
17 1383075 TP53 Regulates Transcription of DNA Repair Genes BioSystems: REACTOME 2.294E-2 3.103E-2
1.159E-1
5.275E-1
 1 72
18 P00059 p53 pathway PantherDB 2.514E-2 3.213E-2
1.200E-1
5.783E-1
 1 79
Show 13 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 659 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26021757 The Cullin 4A/B-DDB1-Cereblon E3 Ubiquitin Ligase Complex Mediates the Degradation of CLC-1 Chloride Channels. Pubmed 2.820E-16 6.534E-14 4.618E-13 1.858E-13 4 5
2 27142104 Expression of the cereblon binding protein argonaute 2 plays an important role for multiple myeloma cell growth and survival. Pubmed 2.820E-16 6.534E-14 4.618E-13 1.858E-13 4 5
3 16964240 Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Pubmed 2.974E-16 6.534E-14 4.618E-13 1.960E-13 5 32
4 18593899 The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Pubmed 8.460E-16 1.394E-13 9.853E-13 5.575E-13 4 6
5 27294876 Immunomodulatory drugs disrupt the cereblon-CD147-MCT1 axis to exert antitumor activity and teratogenicity. Pubmed 1.974E-15 2.602E-13 1.839E-12 1.301E-12 4 7
6 19295130 An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases. Pubmed 7.394E-15 8.121E-13 5.741E-12 4.873E-12 5 59
7 16678110 Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage. Pubmed 1.184E-14 1.115E-12 7.881E-12 7.805E-12 4 10
8 17392787 Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Pubmed 2.186E-13 1.800E-11 1.273E-10 1.440E-10 4 19
9 15811626 DDB2, the xeroderma pigmentosum group E gene product, is directly ubiquitylated by Cullin 4A-based ubiquitin ligase complex. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
10 10585395 Cullin 4A associates with the UV-damaged DNA-binding protein DDB. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
11 19966799 A promiscuous alpha-helical motif anchors viral hijackers and substrate receptors to the CUL4-DDB1 ubiquitin ligase machinery. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
12 22822215 Damaged DNA induced UV-damaged DNA-binding protein (UV-DDB) dimerization and its roles in chromatinized DNA repair. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
13 16951172 DNA damage binding protein component DDB1 participates in nucleotide excision repair through DDB2 DNA-binding and cullin 4A ubiquitin ligase activity. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
14 25860244 Modulation of cereblon levels by anti-myeloma agents. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
15 26231201 A novel effect of thalidomide and its analogs: suppression of cereblon ubiquitination enhances ubiquitin ligase function. Pubmed 1.077E-12 4.732E-11 3.345E-10 7.098E-10 3 3
16 17041588 CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation. Pubmed 1.154E-12 4.754E-11 3.361E-10 7.607E-10 4 28
17 24292625 Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Pubmed 1.545E-12 5.989E-11 4.233E-10 1.018E-9 4 30
18 16949367 A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Pubmed 3.723E-12 1.183E-10 8.362E-10 2.453E-9 4 37
19 20223979 Identification of a primary target of thalidomide teratogenicity. Pubmed 4.308E-12 1.183E-10 8.362E-10 2.839E-9 3 4
20 19818632 CRL4s: the CUL4-RING E3 ubiquitin ligases. Pubmed 4.308E-12 1.183E-10 8.362E-10 2.839E-9 3 4
21 11673459 UV-damaged DNA-binding proteins are targets of CUL-4A-mediated ubiquitination and degradation. Pubmed 4.308E-12 1.183E-10 8.362E-10 2.839E-9 3 4
22 22118460 The molecular basis of CRL4DDB2/CSA ubiquitin ligase architecture, targeting, and activation. Pubmed 4.308E-12 1.183E-10 8.362E-10 2.839E-9 3 4
23 17626091 DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest. Pubmed 4.308E-12 1.183E-10 8.362E-10 2.839E-9 3 4
24 23983124 A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. Pubmed 4.308E-12 1.183E-10 8.362E-10 2.839E-9 3 4
25 21550341 Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best! Pubmed 1.077E-11 2.366E-10 1.672E-9 7.097E-9 3 5
26 22134138 Artemis interacts with the Cul4A-DDB1DDB2 ubiquitin E3 ligase and regulates degradation of the CDK inhibitor p27. Pubmed 1.077E-11 2.366E-10 1.672E-9 7.097E-9 3 5
27 16473935 The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. Pubmed 1.077E-11 2.366E-10 1.672E-9 7.097E-9 3 5
28 24719410 Cullin4A and cullin4B are interchangeable for HIV Vpr and Vpx action through the CRL4 ubiquitin ligase complex. Pubmed 1.077E-11 2.366E-10 1.672E-9 7.097E-9 3 5
29 28437394 Selective degradation of splicing factor CAPERα by anticancer sulfonamides. Pubmed 1.077E-11 2.366E-10 1.672E-9 7.097E-9 3 5
30 28212551 NRIP/DCAF6 stabilizes the androgen receptor protein by displacing DDB2 from the CUL4A-DDB1 E3 ligase complex in prostate cancer. Pubmed 1.077E-11 2.366E-10 1.672E-9 7.097E-9 3 5
31 25795299 CRL4(RBBP7) is required for efficient CENP-A deposition at centromeres. Pubmed 2.154E-11 4.301E-10 3.040E-9 1.419E-8 3 6
32 20932471 CRL4(Cdt2) regulates cell proliferation and histone gene expression by targeting PR-Set7/Set8 for degradation. Pubmed 2.154E-11 4.301E-10 3.040E-9 1.419E-8 3 6
33 16407252 PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. Pubmed 2.154E-11 4.301E-10 3.040E-9 1.419E-8 3 6
34 21228219 Transcriptional and post-translational regulation of the quiescence factor and putative tumor suppressor p150(Sal2). Pubmed 3.769E-11 6.899E-10 4.877E-9 2.484E-8 3 7
35 20368362 DDB2 complex-mediated ubiquitylation around DNA damage is oppositely regulated by XPC and Ku and contributes to the recruitment of XPA. Pubmed 3.769E-11 6.899E-10 4.877E-9 2.484E-8 3 7
36 23297343 Ubiquitin hydrolase UCH-L1 destabilizes mTOR complex 1 by antagonizing DDB1-CUL4-mediated ubiquitination of raptor. Pubmed 3.769E-11 6.899E-10 4.877E-9 2.484E-8 3 7
37 18235224 mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase. Pubmed 6.030E-11 9.935E-10 7.023E-9 3.974E-8 3 8
38 27203177 Autophagic UVRAG Promotes UV-Induced Photolesion Repair by Activation of the CRL4(DDB2) E3 Ligase. Pubmed 6.030E-11 9.935E-10 7.023E-9 3.974E-8 3 8
39 28178526 CRL4 Pubmed 6.030E-11 9.935E-10 7.023E-9 3.974E-8 3 8
40 30018425 The replication initiation determinant protein (RepID) modulates replication by recruiting CUL4 to chromatin. Pubmed 6.030E-11 9.935E-10 7.023E-9 3.974E-8 3 8
41 27325702 Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration. Pubmed 6.845E-11 1.100E-9 7.778E-9 4.511E-8 4 75
42 15448697 Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Pubmed 9.045E-11 1.296E-9 9.160E-9 5.961E-8 3 9
43 18794347 PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex. Pubmed 9.045E-11 1.296E-9 9.160E-9 5.961E-8 3 9
44 28035050 Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Pubmed 9.045E-11 1.296E-9 9.160E-9 5.961E-8 3 9
45 17855541 Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation. Pubmed 9.045E-11 1.296E-9 9.160E-9 5.961E-8 3 9
46 16751180 CSA-dependent degradation of CSB by the ubiquitin-proteasome pathway establishes a link between complementation factors of the Cockayne syndrome. Pubmed 9.045E-11 1.296E-9 9.160E-9 5.961E-8 3 9
47 16861890 L2DTL/CDT2 and PCNA interact with p53 and regulate p53 polyubiquitination and protein stability through MDM2 and CUL4A/DDB1 complexes. Pubmed 1.292E-10 1.812E-9 1.281E-8 8.515E-8 3 10
48 22334663 Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase. Pubmed 1.777E-10 2.439E-9 1.724E-8 1.171E-7 3 11
49 28886238 SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes. Pubmed 2.369E-10 3.061E-9 2.164E-8 1.561E-7 3 12
50 16260596 Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties. Pubmed 2.369E-10 3.061E-9 2.164E-8 1.561E-7 3 12
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 846 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CLCN1 CLCN1 interactions 6.048E-13 2.521E-10 1.845E-9 5.116E-10 4 12
2 int:COPS8 COPS8 interactions 8.358E-13 2.521E-10 1.845E-9 7.071E-10 5 70
3 int:COPS7B COPS7B interactions 9.662E-13 2.521E-10 1.845E-9 8.174E-10 5 72
4 int:GPS1 GPS1 interactions 1.192E-12 2.521E-10 1.845E-9 1.008E-9 5 75
5 int:DDA1 DDA1 interactions 2.005E-12 3.392E-10 2.483E-9 1.696E-9 5 83
6 int:COPS7A COPS7A interactions 4.450E-12 6.275E-10 4.592E-9 3.765E-9 5 97
7 int:COPS3 COPS3 interactions 5.470E-12 6.611E-10 4.838E-9 4.627E-9 5 101
8 int:COPS4 COPS4 interactions 1.492E-11 1.578E-9 1.155E-8 1.262E-8 5 123
9 int:COPS2 COPS2 interactions 1.977E-11 1.858E-9 1.360E-8 1.672E-8 5 130
10 int:RBX1 RBX1 interactions 9.996E-11 8.456E-9 6.189E-8 8.456E-8 5 179
11 int:ERCC8 ERCC8 interactions 4.478E-10 3.444E-8 2.521E-7 3.789E-7 4 56
12 int:CDT1 CDT1 interactions 8.784E-10 6.193E-8 4.532E-7 7.431E-7 4 66
13 int:DDB1 DDB1 interactions 1.243E-9 7.839E-8 5.737E-7 1.051E-6 5 295
14 int:DCAF17 DCAF17 interactions 1.297E-9 7.839E-8 5.737E-7 1.097E-6 3 10
15 int:CUL4A CUL4A interactions 1.446E-9 8.153E-8 5.966E-7 1.223E-6 5 304
16 int:COPS6 COPS6 interactions 1.961E-9 1.037E-7 7.589E-7 1.659E-6 5 323
17 int:DDB2 DDB2 interactions 3.401E-9 1.693E-7 1.239E-6 2.878E-6 4 92
18 int:COP1 COP1 interactions 3.875E-9 1.821E-7 1.333E-6 3.278E-6 4 95
19 int:CUL4B CUL4B interactions 1.528E-8 6.805E-7 4.980E-6 1.293E-5 5 486
20 int:CRYBA4 CRYBA4 interactions 2.483E-8 1.045E-6 7.650E-6 2.101E-5 3 25
21 int:CRBN CRBN interactions 2.595E-8 1.045E-6 7.650E-6 2.195E-5 4 152
22 int:DCAF4 DCAF4 interactions 3.536E-8 1.301E-6 9.518E-6 2.991E-5 3 28
23 int:DCAF16 DCAF16 interactions 3.536E-8 1.301E-6 9.518E-6 2.991E-5 3 28
24 int:GRK5 GRK5 interactions 4.793E-8 1.641E-6 1.201E-5 4.055E-5 4 177
25 int:DET1 DET1 interactions 4.850E-8 1.641E-6 1.201E-5 4.103E-5 3 31
26 int:DCAF4L2 DCAF4L2 interactions 6.456E-8 2.101E-6 1.537E-5 5.461E-5 3 34
27 int:SALL2 SALL2 interactions 8.380E-8 2.532E-6 1.853E-5 7.090E-5 3 37
28 int:DCUN1D5 DCUN1D5 interactions 8.380E-8 2.532E-6 1.853E-5 7.090E-5 3 37
29 int:DCAF10 DCAF10 interactions 9.098E-8 2.654E-6 1.942E-5 7.697E-5 3 38
30 int:DCAF6 DCAF6 interactions 1.149E-7 3.241E-6 2.372E-5 9.723E-5 3 41
31 int:CCNG1 CCNG1 interactions 1.428E-7 3.896E-6 2.851E-5 1.208E-4 3 44
32 int:TRPC4AP TRPC4AP interactions 1.985E-7 5.248E-6 3.841E-5 1.679E-4 3 49
33 int:DCAF11 DCAF11 interactions 2.243E-7 5.751E-6 4.209E-5 1.898E-4 3 51
34 int:ERCC6 ERCC6 interactions 2.381E-7 5.923E-6 4.335E-5 2.014E-4 3 52
35 int:GRWD1 GRWD1 interactions 2.523E-7 6.099E-6 4.463E-5 2.135E-4 3 53
36 int:SAP130 SAP130 interactions 2.671E-7 6.278E-6 4.594E-5 2.260E-4 3 54
37 int:PHIP PHIP interactions 3.150E-7 7.203E-6 5.272E-5 2.665E-4 3 57
38 int:UVRAG UVRAG interactions 3.322E-7 7.396E-6 5.412E-5 2.810E-4 3 58
39 int:DCAF8 DCAF8 interactions 4.700E-7 1.020E-5 7.461E-5 3.976E-4 3 65
40 int:DTL DTL interactions 4.923E-7 1.039E-5 7.607E-5 4.165E-4 3 66
41 int:HIST1H3A HIST1H3A interactions 5.037E-7 1.039E-5 7.607E-5 4.262E-4 4 318
42 int:TOR1AIP2 TOR1AIP2 interactions 5.887E-7 1.186E-5 8.679E-5 4.981E-4 3 70
43 int:USP40 USP40 interactions 6.380E-7 1.227E-5 8.977E-5 5.397E-4 2 5
44 int:DCAF4L1 DCAF4L1 interactions 6.380E-7 1.227E-5 8.977E-5 5.397E-4 2 5
45 int:GLMN GLMN interactions 8.829E-7 1.660E-5 1.215E-4 7.469E-4 3 80
46 int:BANF1 BANF1 interactions 9.168E-7 1.686E-5 1.234E-4 7.756E-4 3 81
47 int:DNMT3B DNMT3B interactions 1.061E-6 1.910E-5 1.398E-4 8.975E-4 3 85
48 int:RBBP5 RBBP5 interactions 1.261E-6 2.178E-5 1.594E-4 1.067E-3 3 90
49 int:WDR26 WDR26 interactions 1.261E-6 2.178E-5 1.594E-4 1.067E-3 3 90
50 int:HOXB4 HOXB4 interactions 1.786E-6 3.022E-5 2.211E-4 1.511E-3 2 8
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3p26.2 3p26.2 5.769E-4 1.442E-3 3.293E-3 2.885E-3 1 4
2 11p12-p11 11p12-p11 7.211E-4 1.442E-3 3.293E-3 3.606E-3 1 5
3 11q12-q13 11q12-q13 8.653E-4 1.442E-3 3.293E-3 4.326E-3 1 6
4 Xq23 Xq23 7.479E-3 8.626E-3 1.970E-2 3.740E-2 1 52
5 13q34 13q34 8.626E-3 8.626E-3 1.970E-2 4.313E-2 1 60

11: Transcription Factor Binding Site [Display Chart] 3 input genes in category / 22 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 4 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1032 Cullins genenames.org 1.015E-6 4.059E-6 8.455E-6 4.059E-6 2 8
2 1269 Nucleotide excision repair genenames.org 5.540E-6 1.108E-5 2.308E-5 2.216E-5 2 18
3 1125 Xeroderma pigmentosum complementation groups genenames.org 1.758E-3 2.344E-3 4.883E-3 7.031E-3 1 8

13: Coexpression [Display Chart] 5 input genes in category / 541 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15930270-Table2 Human Breast Milyavsky05 38genes p53 GeneSigDB 1.212E-5 6.556E-3 4.505E-2 6.556E-3 2 26
2 M1260 Genes up-regulated in rectal cancer patients resistant to radiotherapy (non-responders) relative to the sensitive ones (responders). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.139E-4 2.471E-2
1.698E-1
1.157E-1
 2 108
3 M6085 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (2h) versus IL4 [GeneID=3565] (2h). MSigDB C7: Immunologic Signatures (v6.0) 3.541E-4 2.471E-2
1.698E-1
1.916E-1
 2 139
4 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 4.122E-4 2.471E-2
1.698E-1
2.230E-1
 2 150
5 M9401 Genes up-regulated in T reg: BCL6 [GeneID=604] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 5.668E-4 2.471E-2
1.698E-1
3.066E-1
 2 176
6 16585155-TableS1 Human Colon Watanabe06 214genes GeneSigDB 6.739E-4 2.471E-2
1.698E-1
3.646E-1
 2 192
7 M4005 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.471E-2
1.698E-1
3.915E-1
 2 199
8 M9882 Genes down-regulated in activated CD4 [GeneID=920] T cells: NRAS [GeneID=4893] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.471E-2
1.698E-1
3.915E-1
 2 199
9 M5096 Genes down-regulated in comparison of naive CD8 T cells treated with IL7 [GeneID=3574] versus those treated with IL4 [GeneID=3565] and IL7 [GeneID=3574]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
10 M3834 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
11 M391 Genes down-regulated in neutrophils: MIR223 [GeneID=407008] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
12 M7665 Genes up-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes: non-stimulated versus tretinoin [PubChem=444795] and Pam2CSK4 (96h). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
13 M7884 Genes down-regulated in B cells: light zone versus naïve. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
14 M8048 Genes down-regulated in CD8 T cells: control versus stimulated by IFNA5 [GeneID=3442] and activated by anti-CD3 and anti-CD28. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
15 M4024 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
16 M7780 Genes down-regulated macrophages with MYD88 [GeneID=4615] knockout: untreated versus 12h after M. bovis BCG infection. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.471E-2
1.698E-1
3.954E-1
 2 200
17 15150126-Table2 Human Skin Xu04 6genes GeneSigDB 8.642E-4 2.750E-2
1.890E-1
4.675E-1
 1 4
18 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.647E-4 2.899E-2
1.992E-1
5.219E-1
 2 230
19 15150126-Table1 Human Skin Xu04 11genes GeneSigDB 1.296E-3 3.690E-2
2.536E-1
7.012E-1
 1 6
20 15735009-Table3 Human Lung Mahadevan05 09genes GeneSigDB 1.944E-3 4.768E-2
3.277E-1
1.000E0
 1 9
21 16584549-Table2 Human Colon Xi06 11genes GeneSigDB 2.375E-3 4.768E-2
3.277E-1
1.000E0
 1 11
22 17313671-SuppTable1e Human Leukemia Li07 12genes DNARepair GeneSigDB 2.591E-3 4.768E-2
3.277E-1
1.000E0
 1 12
23 M9811 Genes up-regulated in 293 cells (embryonic kidney) expressing polymorphic variants S427G (SNP ID=rs2070235) or I624M (SNP ID=rs11556379) of BMYB [GeneID=4605]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.806E-3 4.768E-2
3.277E-1
1.000E0
 1 13
24 M29 Genes whose expression positively correlated with that of SMARCA2 [GeneID=6595] in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.230E-3 4.768E-2
3.277E-1
1.000E0
 2 424
25 18722011-SuppTable2m Human Leukemia Sanchez-Guijo08 15genes GeneSigDB 3.238E-3 4.768E-2
3.277E-1
1.000E0
 1 15
26 15896717-Table6 Human Leukemia Bal05 15genes GeneSigDB 3.238E-3 4.768E-2
3.277E-1
1.000E0
 1 15
27 M13806 The v1LDG down-regulated set: most variable late differentiation genes (LDG) with similar expression patterns in tonsil plasma cells (TPC) and multiple myeloma (MM) samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.238E-3 4.768E-2
3.277E-1
1.000E0
 1 15
28 M17836 Genes discriminating TP53 [GeneID=7157] status across various genotoxic stress agents. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.453E-3 4.768E-2
3.277E-1
1.000E0
 1 16
29 15475428-Table5 Human Breast Modlich04 24genes GeneSigDB 3.453E-3 4.768E-2
3.277E-1
1.000E0
 1 16
30 17881637-Table3 Human Lymphoma Young07 29genes GeneSigDB 3.884E-3 4.768E-2
3.277E-1
1.000E0
 1 18
31 15735009-Table1 Human Lung Mahadevan05 18genes GeneSigDB 3.884E-3 4.768E-2
3.277E-1
1.000E0
 1 18
32 M14665 Genes up-regulated in lymphoblastoid cells from the European population compared to those from the Asian population. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.087E-3 4.768E-2
3.277E-1
1.000E0
 2 478
33 18400362-Figure2b Human Lymphoma Staege08 35genes GeneSigDB 4.100E-3 4.768E-2
3.277E-1
1.000E0
 1 19
34 15705792-Table1 Human Leukemia Karawajew05 20genes GeneSigDB 4.100E-3 4.768E-2
3.277E-1
1.000E0
 1 19
35 16849538-Table1b Human Leukemia Camos06 22genes GeneSigDB 4.100E-3 4.768E-2
3.277E-1
1.000E0
 1 19
36 17714734-Table5 Human pancreas Yang09 24genes GeneSigDB 4.315E-3 4.768E-2
3.277E-1
1.000E0
 1 20
37 M18954 Genes up-regulated in HCT116 cells (colon cancer) after treatment with amifostine [PubChem=2141] depending on the presence of TP53 [GeneID=7157]: TP53-positive vs TP53-null cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.768E-2
3.277E-1
1.000E0
 1 20
38 M10922 Genes up-regulated in samples from patients with recurrent hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 4.315E-3 4.768E-2
3.277E-1
1.000E0
 1 20
39 M12605 Genes specifically down-regulated in pediadric acute lymphoblastic leukemia (ALL) patients by mercaptopurine [PubChem=667490]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.746E-3 4.768E-2
3.277E-1
1.000E0
 1 22
40 15958054-Table2 Human Stomach Yanagihara05 35genes GeneSigDB 4.746E-3 4.768E-2
3.277E-1
1.000E0
 1 22
41 16849538-Table1a Human Leukemia Camos06 25genes GeneSigDB 4.746E-3 4.768E-2
3.277E-1
1.000E0
 1 22
42 M10540 Genes up-regulated in gastric cancer cell lines resistant to 5-fluorouracil [PubChem=3385]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.746E-3 4.768E-2
3.277E-1
1.000E0
 1 22
43 M2332 Genes translationally up-regulated by serum in MEF cells (embryonic fibroblast) lacking TSC1 [GeneID=7248]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.961E-3 4.768E-2
3.277E-1
1.000E0
 1 23
44 15583081-Table2 Human Immune Horwitz04 40genes GeneSigDB 5.176E-3 4.768E-2
3.277E-1
1.000E0
 1 24
45 M14024 Genes up-regulated in erythroid progenitor cells isolated from bone marrow of patients with Diamond-Blackfan anemia (DBA) and mutated RPS19 [GeneID=6223]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.391E-3 4.768E-2
3.277E-1
1.000E0
 1 25
46 15475428-Table3 Human Breast Modlich04 37genes GeneSigDB 5.607E-3 4.768E-2
3.277E-1
1.000E0
 1 26
47 17389037-Tab4 Human Breast Turashvili07 32genes GeneSigDB 5.822E-3 4.768E-2
3.277E-1
1.000E0
 1 27
48 16357148-Table1a Human Lung Noh05 43genes GeneSigDB 6.037E-3 4.768E-2
3.277E-1
1.000E0
 1 28
49 M905 Genes down-regulated in C666-1 cells (nasopharyngeal carcinoma) by stable expression of RASSF1 [GeneID=11186]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.252E-3 4.768E-2
3.277E-1
1.000E0
 1 29
50 18310505-TableS6 Human StemCell Matushansky08 35genes GeneSigDB 6.252E-3 4.768E-2
3.277E-1
1.000E0
 1 29
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 147 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 40 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M173 MORF UBE2A Neighborhood of UBE2A MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.313E-4 9.253E-3 3.959E-2 9.253E-3 2 49
2 M5038 MORF BECN1 Neighborhood of BECN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.830E-4 1.966E-2
8.412E-2
 3.932E-2 2 101
3 M6400 MORF TPR Neighborhood of TPR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.987E-3 2.649E-2
1.134E-1
7.948E-2
 2 144
4 M1964 MORF PRKAG1 Neighborhood of PRKAG1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.538E-3 4.379E-2
1.873E-1
1.815E-1
 2 219
5 M5047 MORF DDB1 Neighborhood of DDB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.473E-3 4.379E-2
1.873E-1
2.189E-1
 2 241

16: MicroRNA [Display Chart] 5 input genes in category / 181 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1276:PITA hsa-miR-1276:PITA TOP PITA 2.227E-4 2.902E-2
1.677E-1
 4.030E-2 2 343
2 hsa-miR-3200-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.351E-3 2.902E-2
1.677E-1
4.255E-1
 1 34
3 hsa-miR-635:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.801E-3 2.902E-2
1.677E-1
6.880E-1
 1 55
4 hsa-miR-941:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.801E-3 2.902E-2
1.677E-1
6.880E-1
 1 55
5 hsa-miR-4258:mirSVR highEffct hsa-miR-4258:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.284E-3 2.902E-2
1.677E-1
7.754E-1
 1 62
6 hsa-miR-585:mirSVR highEffct hsa-miR-585:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.560E-3 2.902E-2
1.677E-1
8.253E-1
 1 66
7 hsa-miR-6774-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.902E-2
1.677E-1
8.628E-1
 1 69
8 hsa-miR-1539:mirSVR highEffct hsa-miR-1539:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.836E-3 2.902E-2
1.677E-1
8.753E-1
 1 70
9 hsa-miR-675-5p:Functional MTI Functional MTI miRTarbase 4.836E-3 2.902E-2
1.677E-1
8.753E-1
 1 70
10 hsa-miR-4538:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.902E-2
1.677E-1
9.002E-1
 1 72
11 hsa-miR-4453:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.902E-2
1.677E-1
9.002E-1
 1 72
12 hsa-miR-1293:PITA hsa-miR-1293:PITA TOP PITA 5.111E-3 2.902E-2
1.677E-1
9.252E-1
 1 74
13 hsa-miR-323-5p:PITA hsa-miR-323-5p:PITA TOP PITA 5.318E-3 2.902E-2
1.677E-1
9.626E-1
 1 77
14 hsa-miR-548b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.318E-3 2.902E-2
1.677E-1
9.626E-1
 1 77
15 hsa-miR-1251-5p:TargetScan hsa-miR-1251-5p TargetScan 5.456E-3 2.902E-2
1.677E-1
9.875E-1
 1 79
16 hsa-miR-633:Functional MTI Functional MTI miRTarbase 5.594E-3 2.902E-2
1.677E-1
1.000E0
 1 81
17 hsa-miR-493:PITA hsa-miR-493:PITA TOP PITA 5.663E-3 2.902E-2
1.677E-1
1.000E0
 1 82
18 hsa-miR-4511:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.801E-3 2.902E-2
1.677E-1
1.000E0
 1 84
19 hsa-miR-1255a:PITA hsa-miR-1255a:PITA TOP PITA 5.938E-3 2.902E-2
1.677E-1
1.000E0
 1 86
20 hsa-miR-1255b:PITA hsa-miR-1255b:PITA TOP PITA 5.938E-3 2.902E-2
1.677E-1
1.000E0
 1 86
21 hsa-miR-493-3p:Functional MTI Functional MTI miRTarbase 6.076E-3 2.902E-2
1.677E-1
1.000E0
 1 88
22 hsa-miR-4330:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.352E-3 2.902E-2
1.677E-1
1.000E0
 1 92
23 hsa-miR-675:mirSVR highEffct hsa-miR-675:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.420E-3 2.902E-2
1.677E-1
1.000E0
 1 93
24 hsa-miR-193a-5p:PITA hsa-miR-193a-5p:PITA TOP PITA 6.420E-3 2.902E-2
1.677E-1
1.000E0
 1 93
25 hsa-miR-516b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.420E-3 2.902E-2
1.677E-1
1.000E0
 1 93
26 hsa-miR-7162-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.420E-3 2.902E-2
1.677E-1
1.000E0
 1 93
27 hsa-miR-516a-3p:Functional MTI Functional MTI miRTarbase 6.558E-3 2.902E-2
1.677E-1
1.000E0
 1 95
28 hsa-miR-4432:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.765E-3 2.902E-2
1.677E-1
1.000E0
 1 98
29 hsa-miR-920:PITA hsa-miR-920:PITA TOP PITA 7.109E-3 2.902E-2
1.677E-1
1.000E0
 1 103
30 hsa-miR-99a*:mirSVR highEffct hsa-miR-99a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.934E-3 2.902E-2
1.677E-1
1.000E0
 1 115
31 hsa-miR-1182:PITA hsa-miR-1182:PITA TOP PITA 8.278E-3 2.902E-2
1.677E-1
1.000E0
 1 120
32 hsa-miR-154-3p:TargetScan hsa-miR-154-3p TargetScan 8.347E-3 2.902E-2
1.677E-1
1.000E0
 1 121
33 hsa-miR-487a-3p:TargetScan hsa-miR-487a-3p TargetScan 8.347E-3 2.902E-2
1.677E-1
1.000E0
 1 121
34 hsa-miR-876-3p:PITA hsa-miR-876-3p:PITA TOP PITA 8.484E-3 2.902E-2
1.677E-1
1.000E0
 1 123
35 hsa-miR-671-5p:PITA hsa-miR-671-5p:PITA TOP PITA 9.034E-3 2.902E-2
1.677E-1
1.000E0
 1 131
36 hsa-miR-496.2:TargetScan hsa-miR-496.2 TargetScan 9.103E-3 2.902E-2
1.677E-1
1.000E0
 1 132
37 hsa-miR-4696:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.309E-3 2.902E-2
1.677E-1
1.000E0
 1 135
38 hsa-miR-1266:PITA hsa-miR-1266:PITA TOP PITA 9.447E-3 2.902E-2
1.677E-1
1.000E0
 1 137
39 hsa-miR-3193:mirSVR highEffct hsa-miR-3193:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.013E-2 2.902E-2
1.677E-1
1.000E0
 1 147
40 ATGTTTC,MIR-494:MSigDB ATGTTTC,MIR-494:MSigDB MSigDB 1.013E-2 2.902E-2
1.677E-1
1.000E0
 1 147
41 hsa-miR-181a*:mirSVR highEffct hsa-miR-181a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.013E-2 2.902E-2
1.677E-1
1.000E0
 1 147
42 hsa-miR-137:Non-Functional MTI Non-Functional MTI miRTarbase 1.020E-2 2.902E-2
1.677E-1
1.000E0
 1 148
43 hsa-miR-885-3p:mirSVR highEffct hsa-miR-885-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.027E-2 2.902E-2
1.677E-1
1.000E0
 1 149
44 hsa-miR-451b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.034E-2 2.902E-2
1.677E-1
1.000E0
 1 150
45 hsa-miR-6501-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.082E-2 2.902E-2
1.677E-1
1.000E0
 1 157
46 hsa-miR-663:mirSVR highEffct hsa-miR-663:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.082E-2 2.902E-2
1.677E-1
1.000E0
 1 157
47 hsa-miR-1908:mirSVR highEffct hsa-miR-1908:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.103E-2 2.902E-2
1.677E-1
1.000E0
 1 160
48 hsa-miR-628-3p:PITA hsa-miR-628-3p:PITA TOP PITA 1.103E-2 2.902E-2
1.677E-1
1.000E0
 1 160
49 hsa-miR-6847-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.116E-2 2.902E-2
1.677E-1
1.000E0
 1 162
50 hsa-miR-188-5p:TargetScan hsa-miR-188-5p TargetScan 1.123E-2 2.902E-2
1.677E-1
1.000E0
 1 163
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 580 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006437867 D dB Stitch 5.953E-10 3.453E-7 2.396E-6 3.453E-7 4 77
2 CID000444966 Cu L Stitch 5.355E-8 1.553E-5 1.078E-4 3.106E-5 3 41
3 CID000002782 AL-20 Stitch 2.528E-6 4.888E-4 3.392E-3 1.466E-3 2 12
4 ctd:C408982 CPG-oligonucleotide CTD 5.082E-6 7.370E-4 5.115E-3 2.948E-3 3 184
5 CID000081462 BT-B Stitch 1.171E-5 1.358E-3 9.427E-3 6.791E-3 3 243
6 CID000006090 D.E.T Stitch 1.664E-5 1.608E-3 1.116E-2 9.649E-3 2 30
7 CID000008924 bis(hexamethylene)triamine Stitch 5.876E-5 4.869E-3 3.379E-2 3.408E-2 2 56
8 CID000006366 1,1-dichloroethylene Stitch 6.751E-5 4.895E-3 3.397E-2 3.916E-2 2 60
9 ctd:D011740 Pyrimidine Dimers CTD 2.189E-4 1.297E-2
9.000E-2
1.270E-1
 1 1
10 CID000443071 C11105 Stitch 2.235E-4 1.297E-2
9.000E-2
1.297E-1
 2 109
11 CID000005955 4NQO Stitch 2.532E-4 1.335E-2
9.265E-2
1.468E-1
 2 116
12 ctd:C054672 antimony trichloride CTD 4.378E-4 1.977E-2
1.372E-1
2.539E-1
 1 2
13 CID005289542 UV-C Stitch 4.991E-4 1.977E-2
1.372E-1
2.895E-1
 2 163
14 1138 DN phentolamine; Down 200; 11.5uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 7.130E-4 1.977E-2
1.372E-1
4.135E-1
 2 195
15 1593 DN Ketanserin tartrate hydrate [83846-83-7]; Down 200; 7uM; HL60; HG-U133A Broad Institute CMAP Down 7.203E-4 1.977E-2
1.372E-1
4.177E-1
 2 196
16 2024 UP Hydroxyzine dihydrochloride [2192-20-3]; Up 200; 9uM; HL60; HG-U133A Broad Institute CMAP Up 7.276E-4 1.977E-2
1.372E-1
4.220E-1
 2 197
17 1795 UP Chloramphenicol [56-75-7]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 7.349E-4 1.977E-2
1.372E-1
4.263E-1
 2 198
18 6211 DN Etanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 7.349E-4 1.977E-2
1.372E-1
4.263E-1
 2 198
19 382 UP genistein; Up 200; 10uM; MCF7; HG-U133A Broad Institute CMAP Up 7.349E-4 1.977E-2
1.372E-1
4.263E-1
 2 198
20 1042 DN aspirin, USP; Down 200; 100uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 7.349E-4 1.977E-2
1.372E-1
4.263E-1
 2 198
21 2331 DN Tiapride hydrochloride [51012-33-0]; Down 200; 11uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.423E-4 1.977E-2
1.372E-1
4.306E-1
 2 199
22 1720 DN Gliclazide [21187-98-4]; Down 200; 12.4uM; HL60; HG-U133A Broad Institute CMAP Down 7.498E-4 1.977E-2
1.372E-1
4.349E-1
 2 200
23 CID000009140 benzo(g)chrysene Stitch 1.313E-3 3.311E-2
2.298E-1
7.615E-1
 1 6
24 ctd:D012524 Sarin CTD 1.524E-3 3.683E-2
2.556E-1
8.839E-1
 2 286
25 ctd:C543395 methylarsine CTD 1.969E-3 4.521E-2
3.138E-1
1.000E0
 1 9
26 ctd:C523062 thio-dimethylarsinate CTD 2.187E-3 4.521E-2
3.138E-1
1.000E0
 1 10
27 ctd:D004000 Dichloroethylenes CTD 2.187E-3 4.521E-2
3.138E-1
1.000E0
 1 10
28 CID000002336 benzo(a)pyrene Stitch 2.374E-3 4.521E-2
3.138E-1
1.000E0
 2 358
29 CID000004156 methyl methanesulfonate Stitch 2.453E-3 4.521E-2
3.138E-1
1.000E0
 2 364
30 CID005481180 PMPApp Stitch 3.716E-3 4.521E-2
3.138E-1
1.000E0
 1 17
31 ctd:C467567 lenalidomide CTD 4.153E-3 4.521E-2
3.138E-1
1.000E0
 1 19
32 CID000006235 Trenimon Stitch 4.153E-3 4.521E-2
3.138E-1
1.000E0
 1 19
33 CID000085645 iodine heptafluoride Stitch 4.589E-3 4.521E-2
3.138E-1
1.000E0
 1 21
34 ctd:C062856 dimethylarsine CTD 5.025E-3 4.521E-2
3.138E-1
1.000E0
 1 23
35 ctd:D015376 Nimustine CTD 5.025E-3 4.521E-2
3.138E-1
1.000E0
 1 23
36 CID000020527 N-hydroxy-AABP Stitch 5.897E-3 4.521E-2
3.138E-1
1.000E0
 1 27
37 ctd:C467566 pomalidomide CTD 6.115E-3 4.521E-2
3.138E-1
1.000E0
 1 28
38 CID000101109 illudin S Stitch 6.115E-3 4.521E-2
3.138E-1
1.000E0
 1 28
39 ctd:C482205 nutlin 3 CTD 6.550E-3 4.521E-2
3.138E-1
1.000E0
 1 30
40 CID000003950 lomustine Stitch 6.986E-3 4.521E-2
3.138E-1
1.000E0
 1 32
41 CID000005889 dibenz(a,h)anthracene Stitch 7.204E-3 4.521E-2
3.138E-1
1.000E0
 1 33
42 CID000009119 dibenzo(a,l)pyrene Stitch 8.074E-3 4.521E-2
3.138E-1
1.000E0
 1 37
43 CID000039214 ACNU Stitch 8.509E-3 4.521E-2
3.138E-1
1.000E0
 1 39
44 CID000075394 1-(2-chloroethyl)-1-nitrosourea Stitch 9.161E-3 4.521E-2
3.138E-1
1.000E0
 1 42
45 CID000003213 ellipticine Stitch 1.003E-2 4.521E-2
3.138E-1
1.000E0
 1 46
46 CID000006854 9H-carbazole Stitch 1.112E-2 4.521E-2
3.138E-1
1.000E0
 1 51
47 CID000148189 irofulven Stitch 1.112E-2 4.521E-2
3.138E-1
1.000E0
 1 51
48 CID000024014 CuCl2 Stitch 1.177E-2 4.521E-2
3.138E-1
1.000E0
 1 54
49 CID000008200 tetraethylene glycol Stitch 1.177E-2 4.521E-2
3.138E-1
1.000E0
 1 54
50 ctd:C030299 phenylhydrazine CTD 1.242E-2 4.521E-2
3.138E-1
1.000E0
 1 57
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 180 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1848411 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E DisGeNET Curated 9.124E-6 1.642E-3 9.481E-3 1.642E-3 2 16
2 C0010417 Cryptorchidism DisGeNET Curated 6.111E-5 5.049E-3 2.915E-2 1.100E-2 3 300
3 OMIN:300639 MENTAL RETARDATION, X-LINKED, WITH BRACHYDACTYLY AND MACROGLOSSIA OMIM 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
4 cv:C1845861 X-linked mental retardation with short stature, hypogonadism and abnormal gait Clinical Variations 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
5 OMIN:278740 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP E OMIM 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
6 C1843942 Mental Retardation, Autosomal Recessive 2 DisGeNET Curated 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
7 OMIN:607417 MENTAL RETARDATION, AUTOSOMAL RECESSIVE 2; MRT2 OMIM 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
8 C1845861 MENTAL RETARDATION, X-LINKED, WITH SHORT STATURE, HYPOGONADISM, AND ABNORMAL GAIT DisGeNET Curated 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
9 cv:C1848411 Xeroderma pigmentosum, group E Clinical Variations 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
10 C4023721 Abnormal hair pattern DisGeNET Curated 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
11 cv:C1843942 Mental retardation, autosomal recessive 2 Clinical Variations 3.085E-4 5.049E-3 2.915E-2
5.554E-2
 1 1
12 C0043346 Xeroderma Pigmentosum DisGeNET Curated 4.184E-4 6.277E-3 3.624E-2
7.532E-2
 2 106
13 C0683322 Mental impairment DisGeNET Curated 6.001E-4 7.933E-3 4.580E-2
1.080E-1
 2 127
14 C0554985 Aggressive outburst DisGeNET BeFree 6.170E-4 7.933E-3 4.580E-2
1.111E-1
 1 2
15 C0020619 Hypogonadism DisGeNET Curated 7.285E-4 8.743E-3
5.047E-2
1.311E-1
 2 140
16 C0795806 Chromosome 3, monosomy 3p DisGeNET Curated 9.254E-4 9.798E-3
5.657E-2
1.666E-1
 1 3
17 C0849640 skin damage DisGeNET BeFree 9.254E-4 9.798E-3
5.657E-2
1.666E-1
 1 3
18 C4021808 Abnormality of earlobe DisGeNET Curated 1.542E-3 1.471E-2
8.494E-2
2.776E-1
 1 5
19 C0240635 Byzanthine arch palate DisGeNET Curated 1.553E-3 1.471E-2
8.494E-2
2.796E-1
 2 205
20 C1968564 Defective DNA repair after ultraviolet radiation damage DisGeNET Curated 2.158E-3 1.942E-2
1.121E-1
3.885E-1
 1 7
21 C0014390 Entropion DisGeNET Curated 2.466E-3 2.114E-2
1.220E-1
4.439E-1
 1 8
22 C0007114 Malignant neoplasm of skin DisGeNET Curated 2.637E-3 2.157E-2
1.245E-1
4.746E-1
 2 268
23 C1332986 Childhood Osteosarcoma DisGeNET BeFree 3.082E-3 2.412E-2
1.392E-1
5.548E-1
 1 10
24 C1849075 Relative macrocephaly DisGeNET Curated 4.005E-3 3.004E-2
1.734E-1
7.209E-1
 1 13
25 C0239105 Conjunctival telangiectasis DisGeNET Curated 4.313E-3 3.105E-2
1.793E-1
7.763E-1
 1 14
26 C1138421 Spider Veins DisGeNET Curated 5.235E-3 3.539E-2
2.043E-1
9.423E-1
 1 17
27 C0856863 Broad-based gait DisGeNET Curated 5.849E-3 3.539E-2
2.043E-1
1.000E0
 1 19
28 C0392777 Poikiloderma DisGeNET Curated 5.849E-3 3.539E-2
2.043E-1
1.000E0
 1 19
29 C1389016 ATRIOVENTRICULAR CANAL DEFECT DisGeNET Curated 6.156E-3 3.539E-2
2.043E-1
1.000E0
 1 20
30 C0013592 Ectropion DisGeNET Curated 6.464E-3 3.539E-2
2.043E-1
1.000E0
 1 21
31 C1856872 Sloping shoulders DisGeNET Curated 6.464E-3 3.539E-2
2.043E-1
1.000E0
 1 21
32 C0266061 Open Bite DisGeNET Curated 6.770E-3 3.539E-2
2.043E-1
1.000E0
 1 22
33 C1400105 Hypertrophy of nose DisGeNET Curated 7.077E-3 3.539E-2
2.043E-1
1.000E0
 1 23
34 C4280629 Hyperplasia of nose DisGeNET Curated 7.077E-3 3.539E-2
2.043E-1
1.000E0
 1 23
35 C0426415 Large nose DisGeNET Curated 7.077E-3 3.539E-2
2.043E-1
1.000E0
 1 23
36 C1862314 Basal cell nevi DisGeNET Curated 7.077E-3 3.539E-2
2.043E-1
1.000E0
 1 23
37 C1840069 Sandal gap DisGeNET Curated 7.384E-3 3.592E-2
2.074E-1
1.000E0
 1 24
38 C0311277 Obesity, Abdominal DisGeNET Curated 8.304E-3 3.934E-2
2.271E-1
1.000E0
 1 27
39 C2752147 XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP C DisGeNET Curated 9.223E-3 4.096E-2
2.365E-1
1.000E0
 1 30
40 C0234376 Action Tremor DisGeNET Curated 9.223E-3 4.096E-2
2.365E-1
1.000E0
 1 30
41 C0016689 Freckles DisGeNET Curated 1.014E-2 4.096E-2
2.365E-1
1.000E0
 1 33
42 C0740404 limb defects DisGeNET BeFree 1.014E-2 4.096E-2
2.365E-1
1.000E0
 1 33
43 C1846149 Progressive mental retardation DisGeNET Curated 1.137E-2 4.096E-2
2.365E-1
1.000E0
 1 37
44 C0339510 Vitelliform Macular Dystrophy DisGeNET Curated 1.137E-2 4.096E-2
2.365E-1
1.000E0
 1 37
45 C1864156 Conjunctivitis, recurrent DisGeNET Curated 1.137E-2 4.096E-2
2.365E-1
1.000E0
 1 37
46 C0014116 Endocardial Cushion Defects DisGeNET Curated 1.198E-2 4.096E-2
2.365E-1
1.000E0
 1 39
47 C0009763 Conjunctivitis DisGeNET Curated 1.198E-2 4.096E-2
2.365E-1
1.000E0
 1 39
48 C0575802 Small hand DisGeNET Curated 1.198E-2 4.096E-2
2.365E-1
1.000E0
 1 39
49 C0431447 Synophrys DisGeNET Curated 1.228E-2 4.096E-2
2.365E-1
1.000E0
 1 40
50 C4022018 Telangiectasia of the skin DisGeNET Curated 1.228E-2 4.096E-2
2.365E-1
1.000E0
 1 40
Show 45 more annotations