Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc128_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 25 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031773 kisspeptin receptor binding 3.751E-4 4.689E-3 1.789E-2 9.378E-3 1 1
2 GO:0005183 gonadotropin hormone-releasing hormone activity 3.751E-4 4.689E-3 1.789E-2 9.378E-3 1 1
3 GO:0004968 gonadotropin-releasing hormone receptor activity 1.125E-3 9.375E-3 3.577E-2 2.812E-2 1 3
4 GO:0035613 RNA stem-loop binding 3.746E-3 1.842E-2
7.028E-2
9.364E-2
 1 10
5 GO:0004983 neuropeptide Y receptor activity 3.746E-3 1.842E-2
7.028E-2
9.364E-2
 1 10
6 GO:0042277 peptide binding 4.420E-3 1.842E-2
7.028E-2
1.105E-1
 2 278
7 GO:0033218 amide binding 5.432E-3 1.871E-2
7.140E-2
1.358E-1
 2 309
8 GO:0016500 protein-hormone receptor activity 5.987E-3 1.871E-2
7.140E-2
1.497E-1
 1 16
9 GO:0071855 neuropeptide receptor binding 1.157E-2 3.215E-2
1.227E-1
2.893E-1
 1 31
10 GO:0017046 peptide hormone binding 1.676E-2 3.579E-2
1.366E-1
4.190E-1
 1 45
11 GO:0008188 neuropeptide receptor activity 1.713E-2 3.579E-2
1.366E-1
4.283E-1
 1 46
12 GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding 1.861E-2 3.579E-2
1.366E-1
4.652E-1
 1 50
13 GO:0004879 nuclear receptor activity 1.861E-2 3.579E-2
1.366E-1
4.652E-1
 1 50
14 GO:0003707 steroid hormone receptor activity 2.193E-2 3.915E-2
1.494E-1
5.482E-1
 1 59
15 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 2.634E-2 4.389E-2
1.675E-1
6.584E-1
 1 71
16 GO:0042562 hormone binding 3.073E-2 4.801E-2
1.832E-1
7.682E-1
 1 83
Show 11 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 174 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007565 female pregnancy 6.107E-7 9.354E-5 5.368E-4 1.063E-4 4 217
2 GO:0044706 multi-multicellular organism process 1.075E-6 9.354E-5 5.368E-4 1.871E-4 4 250
3 GO:0022602 ovulation cycle process 6.898E-6 4.001E-4 2.296E-3 1.200E-3 3 110
4 GO:2000194 regulation of female gonad development 9.428E-6 4.101E-4 2.354E-3 1.640E-3 2 13
5 GO:0042698 ovulation cycle 1.364E-5 4.745E-4 2.723E-3 2.373E-3 3 138
6 GO:0007530 sex determination 3.618E-5 1.049E-3 6.022E-3 6.296E-3 2 25
7 GO:0048511 rhythmic process 2.485E-4 6.177E-3 3.545E-2 4.324E-2 3 366
8 GO:0048608 reproductive structure development 5.614E-4 1.112E-2
6.381E-2
9.768E-2
 3 483
9 GO:0061458 reproductive system development 5.751E-4 1.112E-2
6.381E-2
1.001E-1
 3 487
10 GO:0007218 neuropeptide signaling pathway 6.740E-4 1.173E-2
6.731E-2
1.173E-1
 2 107
11 GO:0008585 female gonad development 9.328E-4 1.308E-2
7.505E-2
1.623E-1
 2 126
12 GO:0046545 development of primary female sexual characteristics 1.008E-3 1.308E-2
7.505E-2
1.753E-1
 2 131
13 GO:1990637 response to prolactin 1.127E-3 1.308E-2
7.505E-2
1.961E-1
 1 3
14 GO:0007538 primary sex determination 1.127E-3 1.308E-2
7.505E-2
1.961E-1
 1 3
15 GO:0060112 generation of ovulation cycle rhythm 1.127E-3 1.308E-2
7.505E-2
1.961E-1
 1 3
16 GO:0046660 female sex differentiation 1.249E-3 1.314E-2
7.539E-2
2.174E-1
 2 146
17 GO:2000241 regulation of reproductive process 1.283E-3 1.314E-2
7.539E-2
2.233E-1
 2 148
18 GO:2000195 negative regulation of female gonad development 1.503E-3 1.376E-2
7.898E-2
2.615E-1
 1 4
19 GO:0033686 positive regulation of luteinizing hormone secretion 1.503E-3 1.376E-2
7.898E-2
2.615E-1
 1 4
20 GO:2000354 regulation of ovarian follicle development 1.878E-3 1.634E-2
9.378E-2
3.268E-1
 1 5
21 GO:0033087 negative regulation of immature T cell proliferation 2.253E-3 1.867E-2
1.071E-1
3.921E-1
 1 6
22 GO:0042445 hormone metabolic process 2.513E-3 1.867E-2
1.071E-1
4.372E-1
 2 208
23 GO:0030336 negative regulation of cell migration 2.907E-3 1.867E-2
1.071E-1
5.058E-1
 2 224
24 GO:0097210 response to gonadotropin-releasing hormone 3.004E-3 1.867E-2
1.071E-1
5.226E-1
 1 8
25 GO:0032278 positive regulation of gonadotropin secretion 3.004E-3 1.867E-2
1.071E-1
5.226E-1
 1 8
26 GO:2000020 positive regulation of male gonad development 3.004E-3 1.867E-2
1.071E-1
5.226E-1
 1 8
27 GO:0097211 cellular response to gonadotropin-releasing hormone 3.004E-3 1.867E-2
1.071E-1
5.226E-1
 1 8
28 GO:0007217 tachykinin receptor signaling pathway 3.004E-3 1.867E-2
1.071E-1
5.226E-1
 1 8
29 GO:2000146 negative regulation of cell motility 3.194E-3 1.916E-2
1.100E-1
5.557E-1
 2 235
30 GO:0033684 regulation of luteinizing hormone secretion 3.379E-3 1.960E-2
1.125E-1
5.879E-1
 1 9
31 GO:0008406 gonad development 3.634E-3 1.991E-2
1.143E-1
6.323E-1
 2 251
32 GO:0060124 positive regulation of growth hormone secretion 3.753E-3 1.991E-2
1.143E-1
6.531E-1
 1 10
33 GO:0045137 development of primary sexual characteristics 3.777E-3 1.991E-2
1.143E-1
6.572E-1
 2 256
34 GO:2000018 regulation of male gonad development 4.128E-3 1.997E-2
1.146E-1
7.183E-1
 1 11
35 GO:2001223 negative regulation of neuron migration 4.128E-3 1.997E-2
1.146E-1
7.183E-1
 1 11
36 GO:0051271 negative regulation of cellular component movement 4.131E-3 1.997E-2
1.146E-1
7.188E-1
 2 268
37 GO:0033083 regulation of immature T cell proliferation 4.503E-3 2.083E-2
1.195E-1
7.834E-1
 1 12
38 GO:0033079 immature T cell proliferation 4.877E-3 2.083E-2
1.195E-1
8.486E-1
 1 13
39 GO:0032275 luteinizing hormone secretion 4.877E-3 2.083E-2
1.195E-1
8.486E-1
 1 13
40 GO:0040013 negative regulation of locomotion 4.950E-3 2.083E-2
1.195E-1
8.613E-1
 2 294
41 GO:0060123 regulation of growth hormone secretion 5.251E-3 2.083E-2
1.195E-1
9.137E-1
 1 14
42 GO:0001553 luteinization 5.251E-3 2.083E-2
1.195E-1
9.137E-1
 1 14
43 GO:0032276 regulation of gonadotropin secretion 5.251E-3 2.083E-2
1.195E-1
9.137E-1
 1 14
44 GO:0007568 aging 5.420E-3 2.083E-2
1.195E-1
9.430E-1
 2 308
45 GO:0007548 sex differentiation 5.454E-3 2.083E-2
1.195E-1
9.490E-1
 2 309
46 GO:0030238 male sex determination 5.625E-3 2.083E-2
1.195E-1
9.788E-1
 1 15
47 GO:0051457 maintenance of protein location in nucleus 5.625E-3 2.083E-2
1.195E-1
9.788E-1
 1 15
48 GO:0035864 response to potassium ion 6.000E-3 2.130E-2
1.223E-1
1.000E0
 1 16
49 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 6.000E-3 2.130E-2
1.223E-1
1.000E0
 1 16
50 GO:0048026 positive regulation of mRNA splicing, via spliceosome 6.747E-3 2.302E-2
1.321E-1
1.000E0
 1 18
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 17 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098556 cytoplasmic side of rough endoplasmic reticulum membrane 3.672E-4 3.122E-3 1.074E-2 6.243E-3 1 1
2 GO:1990008 neurosecretory vesicle 3.672E-4 3.122E-3 1.074E-2 6.243E-3 1 1
3 GO:1990005 granular vesicle 7.344E-4 4.161E-3 1.431E-2 1.248E-2 1 2
4 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane 3.301E-3 1.403E-2 4.825E-2
5.612E-2
 1 9
5 GO:0030867 rough endoplasmic reticulum membrane 7.688E-3 2.614E-2
8.991E-2
1.307E-1
 1 21

4: Human Phenotype [Display Chart] 4 input genes in category / 210 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011961 Non-obstructive azoospermia 1.163E-9 2.019E-7 1.196E-6 2.442E-7 4 29
2 HP:0008230 Decreased testosterone in males 2.563E-9 2.019E-7 1.196E-6 5.383E-7 4 35
3 HP:0000026 Male hypogonadism 2.884E-9 2.019E-7 1.196E-6 6.056E-7 4 36
4 HP:0040171 Decreased serum testosterone level 5.479E-9 2.188E-7 1.297E-6 1.151E-6 4 42
5 HP:0008187 Absence of secondary sex characteristics 6.646E-9 2.188E-7 1.297E-6 1.396E-6 4 44
6 HP:0030349 Decreased circulating androgen level 7.294E-9 2.188E-7 1.297E-6 1.532E-6 4 45
7 HP:0030087 Abnormal serum testosterone level 7.294E-9 2.188E-7 1.297E-6 1.532E-6 4 45
8 HP:0045014 Hypolipidemia 8.732E-9 2.292E-7 1.358E-6 1.834E-6 4 47
9 HP:0030347 Abnormal circulating androgen level 1.127E-8 2.631E-7 1.559E-6 2.368E-6 4 50
10 HP:0000013 Hypoplasia of the uterus 1.670E-8 3.506E-7 2.078E-6 3.506E-6 4 55
11 HP:0000869 Secondary amenorrhea 2.077E-8 3.965E-7 2.350E-6 4.362E-6 4 58
12 HP:0010311 Aplasia/Hypoplasia of the breasts 2.555E-8 4.471E-7 2.650E-6 5.365E-6 4 61
13 HP:0008724 Hypoplasia of the ovary 3.314E-8 4.972E-7 2.947E-6 6.960E-6 4 65
14 HP:0010462 Aplasia/Hypoplasia of the ovary 3.314E-8 4.972E-7 2.947E-6 6.960E-6 4 65
15 HP:0008684 Aplasia/hypoplasia of the uterus 3.987E-8 5.581E-7 3.308E-6 8.372E-6 4 68
16 HP:0031066 Abnormal ovarian physiology 7.355E-8 9.654E-7 5.722E-6 1.545E-5 4 79
17 HP:0000786 Primary amenorrhea 1.558E-7 1.925E-6 1.141E-5 3.273E-5 4 95
18 HP:0030019 Increased female libido 1.875E-7 2.187E-6 1.296E-5 3.937E-5 3 18
19 HP:0000044 Hypogonadotrophic hypogonadism 2.623E-7 2.900E-6 1.719E-5 5.509E-5 4 108
20 HP:0000771 Gynecomastia 3.384E-7 3.384E-6 2.006E-5 7.107E-5 4 115
21 HP:0000770 Male breast abnormality 3.384E-7 3.384E-6 2.006E-5 7.107E-5 4 115
22 HP:0000027 Azoospermia 3.629E-7 3.464E-6 2.053E-5 7.622E-5 4 117
23 HP:0008197 Absence of pubertal development 4.065E-7 3.712E-6 2.200E-5 8.537E-5 3 23
24 HP:0003782 Eunuchoid habitus 5.278E-7 4.618E-6 2.737E-5 1.108E-4 3 25
25 HP:0031065 Abnormal ovarian morphology 6.478E-7 5.232E-6 3.101E-5 1.360E-4 4 135
26 HP:0008669 Abnormal spermatogenesis 6.478E-7 5.232E-6 3.101E-5 1.360E-4 4 135
27 HP:0000134 Female hypogonadism 7.514E-7 5.844E-6 3.464E-5 1.578E-4 3 28
28 HP:0002761 Generalized joint laxity 1.250E-6 9.010E-6 5.340E-5 2.626E-4 3 33
29 HP:0008734 Decreased testicular size 1.287E-6 9.010E-6 5.340E-5 2.703E-4 4 160
30 HP:0000141 Amenorrhea 1.287E-6 9.010E-6 5.340E-5 2.703E-4 4 160
31 HP:0000025 Functional abnormality of male internal genitalia 1.422E-6 9.634E-6 5.710E-5 2.987E-4 4 164
32 HP:0003187 Breast hypoplasia 2.092E-6 1.373E-5 8.138E-5 4.394E-4 3 39
33 HP:0010468 Aplasia/Hypoplasia of the testes 2.165E-6 1.378E-5 8.165E-5 4.546E-4 4 182
34 HP:0030014 Female sexual dysfunction 2.824E-6 1.744E-5 1.034E-4 5.930E-4 3 43
35 HP:0045058 Abnormality of the testis size 2.919E-6 1.751E-5 1.038E-4 6.130E-4 4 196
36 HP:0030012 Abnormal female reproductive system physiology 3.030E-6 1.767E-5 1.048E-4 6.363E-4 3 44
37 HP:0002555 Absent pubic hair 3.249E-6 1.844E-5 1.093E-4 6.822E-4 2 4
38 HP:0002231 Sparse body hair 4.480E-6 2.476E-5 1.467E-4 9.407E-4 3 50
39 HP:0000054 Micropenis 4.735E-6 2.531E-5 1.500E-4 9.943E-4 4 221
40 HP:0012874 Abnormal male reproductive system physiology 4.822E-6 2.531E-5 1.500E-4 1.013E-3 4 222
41 HP:0000823 Delayed puberty 6.274E-6 3.213E-5 1.904E-4 1.317E-3 4 237
42 HP:0000130 Abnormality of the uterus 8.557E-6 4.278E-5 2.536E-4 1.797E-3 4 256
43 HP:0000938 Osteopenia 9.685E-6 4.730E-5 2.803E-4 2.034E-3 4 264
44 HP:0002750 Delayed skeletal maturation 1.210E-5 5.773E-5 3.421E-4 2.540E-3 4 279
45 HP:0000137 Abnormality of the ovary 1.318E-5 6.149E-5 3.644E-4 2.767E-3 4 285
46 HP:0010718 Abnormality of habitus 1.416E-5 6.457E-5 3.827E-4 2.974E-3 3 73
47 HP:0006610 Wide intermamillary distance 1.476E-5 6.457E-5 3.827E-4 3.099E-3 3 74
48 HP:0040157 Abnormal intermamillary distance 1.476E-5 6.457E-5 3.827E-4 3.099E-3 3 74
49 HP:0008070 Sparse hair 1.619E-5 6.940E-5 4.113E-4 3.401E-3 4 300
50 HP:0011357 Abnormality of hair density 1.824E-5 7.659E-5 4.540E-4 3.830E-3 4 309
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 5 input genes in category / 268 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002636 delayed vaginal opening 5.053E-11 1.022E-8 6.307E-8 1.354E-8 4 20
2 MP:0020150 abnormal timing of vaginal opening 7.629E-11 1.022E-8 6.307E-8 2.044E-8 4 22
3 MP:0002790 decreased circulating follicle stimulating hormone level 9.517E-10 8.502E-8 5.246E-7 2.551E-7 4 40
4 MP:0005130 decreased follicle stimulating hormone level 2.600E-9 1.742E-7 1.075E-6 6.969E-7 4 51
5 MP:0001937 abnormal sexual maturation 5.426E-9 2.590E-7 1.598E-6 1.454E-6 4 61
6 MP:0003363 decreased circulating gonadotropin level 5.800E-9 2.590E-7 1.598E-6 1.554E-6 4 62
7 MP:0002212 abnormal secondary sex determination 1.481E-8 5.671E-7 3.499E-6 3.969E-6 4 78
8 MP:0003967 abnormal follicle stimulating hormone level 3.162E-8 1.059E-6 6.537E-6 8.475E-6 4 94
9 MP:0005118 decreased circulating pituitary hormone level 4.582E-8 1.364E-6 8.418E-6 1.228E-5 4 103
10 MP:0003361 abnormal circulating gonadotropin level 6.667E-8 1.747E-6 1.078E-5 1.787E-5 4 113
11 MP:0005189 abnormal anogenital distance 7.170E-8 1.747E-6 1.078E-5 1.922E-5 3 21
12 MP:0003972 decreased pituitary hormone level 9.706E-8 2.168E-6 1.337E-5 2.601E-5 4 124
13 MP:0001127 small ovary 1.982E-7 4.086E-6 2.521E-5 5.311E-5 4 148
14 MP:0003315 abnormal perineum morphology 2.186E-7 4.185E-6 2.582E-5 5.859E-5 3 30
15 MP:0009010 abnormal diestrus 2.420E-7 4.324E-6 2.668E-5 6.485E-5 3 31
16 MP:0004853 abnormal ovary size 3.381E-7 5.663E-6 3.494E-5 9.062E-5 4 169
17 MP:0004856 decreased ovary weight 4.179E-7 6.589E-6 4.065E-5 1.120E-4 3 37
18 MP:0005116 abnormal circulating pituitary hormone level 5.301E-7 7.892E-6 4.870E-5 1.421E-4 4 189
19 MP:0005132 decreased luteinizing hormone level 6.170E-7 8.703E-6 5.370E-5 1.654E-4 3 42
20 MP:0004854 abnormal ovary weight 6.632E-7 8.887E-6 5.483E-5 1.777E-4 3 43
21 MP:0003965 abnormal pituitary hormone level 1.030E-6 1.314E-5 8.107E-5 2.759E-4 4 223
22 MP:0009199 abnormal external male genitalia morphology 1.186E-6 1.445E-5 8.915E-5 3.179E-4 3 52
23 MP:0002780 decreased circulating testosterone level 1.834E-6 2.068E-5 1.276E-4 4.916E-4 3 60
24 MP:0003379 absent sexual maturation 1.864E-6 2.068E-5 1.276E-4 4.996E-4 2 5
25 MP:0001157 small seminal vesicle 1.929E-6 2.068E-5 1.276E-4 5.170E-4 3 61
26 MP:0001134 absent corpus luteum 2.232E-6 2.301E-5 1.420E-4 5.982E-4 3 64
27 MP:0002637 small uterus 2.684E-6 2.584E-5 1.594E-4 7.192E-4 3 68
28 MP:0008297 retention of the adrenal gland x-zone 2.796E-6 2.584E-5 1.594E-4 7.493E-4 2 6
29 MP:0005148 seminal vesicle hypoplasia 2.796E-6 2.584E-5 1.594E-4 7.493E-4 2 6
30 MP:0005180 abnormal circulating testosterone level 3.612E-6 3.149E-5 1.943E-4 9.680E-4 3 75
31 MP:0009819 abnormal circulating androgen level 3.760E-6 3.149E-5 1.943E-4 1.008E-3 3 76
32 MP:0003969 abnormal luteinizing hormone level 3.760E-6 3.149E-5 1.943E-4 1.008E-3 3 76
33 MP:0008296 abnormal adrenal gland x-zone morphology 3.914E-6 3.178E-5 1.961E-4 1.049E-3 2 7
34 MP:0011385 abnormal testosterone level 4.068E-6 3.206E-5 1.978E-4 1.090E-3 3 78
35 MP:0001126 abnormal ovary morphology 4.705E-6 3.602E-5 2.223E-4 1.261E-3 4 326
36 MP:0004907 abnormal seminal vesicle size 4.909E-6 3.655E-5 2.255E-4 1.316E-3 3 83
37 MP:0000618 small salivary gland 5.217E-6 3.779E-5 2.332E-4 1.398E-3 2 8
38 MP:0002786 abnormal Leydig cell morphology 5.466E-6 3.855E-5 2.378E-4 1.465E-3 3 86
39 MP:0001260 increased body weight 6.247E-6 4.185E-5 2.582E-4 1.674E-3 4 350
40 MP:0012323 increased total tissue mass 6.247E-6 4.185E-5 2.582E-4 1.674E-3 4 350
41 MP:0009444 ovarian follicular cyst 6.706E-6 4.355E-5 2.687E-4 1.797E-3 2 9
42 MP:0013324 abnormal female reproductive gland morphology 7.146E-6 4.355E-5 2.687E-4 1.915E-3 4 362
43 MP:0001927 abnormal estrous cycle 7.150E-6 4.355E-5 2.687E-4 1.916E-3 3 94
44 MP:0009344 abnormal ovulation cycle 7.150E-6 4.355E-5 2.687E-4 1.916E-3 3 94
45 MP:0005188 small penis 8.381E-6 4.992E-5 3.080E-4 2.246E-3 2 10
46 MP:0001264 increased body size 9.915E-6 5.693E-5 3.513E-4 2.657E-3 4 393
47 MP:0001130 abnormal ovarian folliculogenesis 9.984E-6 5.693E-5 3.513E-4 2.676E-3 3 105
48 MP:0004902 abnormal uterus size 1.087E-5 6.068E-5 3.744E-4 2.913E-3 3 108
49 MP:0002679 abnormal corpus luteum morphology 1.213E-5 6.586E-5 4.064E-4 3.250E-3 3 112
50 MP:0009019 abnormal metestrus 1.229E-5 6.586E-5 4.064E-4 3.293E-3 2 12
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 35 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF15152 Kisspeptin Pfam 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
2 PD088121 Metastasis-suppressor KiSS-1 ProDom 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
3 IPR003635 Neurokinin-B/TAC3 InterPro 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
4 IPR001402 Prolrel pep rcpt InterPro 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
5 IPR020207 Metastasis-suppressor KiSS-1 InterPro 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
6 PF03823 Neurokinin B Pfam 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
7 IPR004079 Gonadoliberin I precursor InterPro 3.736E-4 1.868E-3 7.747E-3 1.308E-2 1 1
8 IPR001658 GphnRH fam rcpt InterPro 7.471E-4 2.012E-3 8.341E-3 2.615E-2 1 2
9 PS00473 GNRH PROSITE 7.471E-4 2.012E-3 8.341E-3 2.615E-2 1 2
10 PF00446 GnRH Pfam 7.471E-4 2.012E-3 8.341E-3 2.615E-2 1 2
11 IPR002012 GnRH InterPro 7.471E-4 2.012E-3 8.341E-3 2.615E-2 1 2
12 IPR016355 NR5 fam InterPro 7.471E-4 2.012E-3 8.341E-3 2.615E-2 1 2
13 IPR019792 Gonadoliberin I InterPro 7.471E-4 2.012E-3 8.341E-3 2.615E-2 1 2
14 IPR013055 Tachy Neuro lke CS InterPro 1.121E-3 2.615E-3 1.084E-2 3.922E-2 1 3
15 PS00267 TACHYKININ PROSITE 1.121E-3 2.615E-3 1.084E-2 3.922E-2 1 3
16 IPR000324 VitD rcpt InterPro 5.220E-3 1.142E-2 4.735E-2
1.827E-1
 1 14
17 PS00031 NUCLEAR REC DBD 1 PROSITE 1.706E-2 2.396E-2
9.936E-2
5.972E-1
 1 46
18 SM00399 ZnF C4 SMART 1.706E-2 2.396E-2
9.936E-2
5.972E-1
 1 46
19 IPR001723 Nuclear hrmn rcpt InterPro 1.706E-2 2.396E-2
9.936E-2
5.972E-1
 1 46
20 IPR001628 Znf hrmn rcpt InterPro 1.706E-2 2.396E-2
9.936E-2
5.972E-1
 1 46
21 PF00105 zf-C4 Pfam 1.706E-2 2.396E-2
9.936E-2
5.972E-1
 1 46
22 PS51030 NUCLEAR REC DBD 2 PROSITE 1.706E-2 2.396E-2
9.936E-2
5.972E-1
 1 46
23 1.10.565.10 - Gene3D 1.743E-2 2.396E-2
9.936E-2
6.101E-1
 1 47
24 PF00104 Hormone recep Pfam 1.780E-2 2.396E-2
9.936E-2
6.230E-1
 1 48
25 SM00430 HOLI SMART 1.780E-2 2.396E-2
9.936E-2
6.230E-1
 1 48
26 IPR000536 Nucl hrmn rcpt lig-bd InterPro 1.780E-2 2.396E-2
9.936E-2
6.230E-1
 1 48
27 3.30.50.10 - Gene3D 2.111E-2 2.684E-2
1.113E-1
7.387E-1
 1 57
28 IPR013088 Znf NHR/GATA InterPro 2.147E-2 2.684E-2
1.113E-1
7.516E-1
 1 58
29 SM01381 7TM GPCR Srsx SMART 4.111E-2 4.962E-2
2.057E-1
1.000E0
 1 112
Show 24 more annotations

7: Pathway [Display Chart] 7 input genes in category / 14 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 2.258E-7 3.162E-6 1.028E-5 3.162E-6 5 322
2 1269544 GPCR ligand binding BioSystems: REACTOME 1.261E-6 8.636E-6 2.808E-5 1.765E-5 5 455
3 1269578 G alpha (q) signalling events BioSystems: REACTOME 1.851E-6 8.636E-6 2.808E-5 2.591E-5 4 192
4 1269559 Hormone ligand-binding receptors BioSystems: REACTOME 2.107E-5 7.376E-5 2.398E-4 2.950E-4 2 13
5 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 5.219E-5 1.461E-4 4.751E-4 7.306E-4 4 446
6 1269546 Peptide ligand-binding receptors BioSystems: REACTOME 1.134E-4 2.647E-4 8.606E-4 1.588E-3 3 188
7 1269548 Tachykinin receptors bind tachykinins BioSystems: REACTOME 2.809E-3 5.617E-3 1.826E-2 3.932E-2 1 5
8 PW:0000540 obesity disease Pathway Ontology 4.490E-3 7.858E-3 2.555E-2
6.287E-2
 1 8
9 138048 Nongenotropic Androgen signaling BioSystems: Pathway Interaction Database 1.008E-2 1.568E-2
5.098E-2
1.411E-1
 1 18
10 1270346 Transcriptional regulation of pluripotent stem cells BioSystems: REACTOME 2.007E-2 2.810E-2
9.137E-2
2.810E-1
 1 36
11 1269652 Nuclear Receptor transcription pathway BioSystems: REACTOME 2.833E-2 3.606E-2
1.172E-1
3.966E-1
 1 51
Show 6 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 1503 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20529119 The kisspeptin system of the human hypothalamus: sexual dimorphism and relationship with gonadotropin-releasing hormone and neurokinin B neurons. Pubmed 3.770E-12 5.666E-9 4.472E-8 5.666E-9 3 3
2 24130552 Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain. Pubmed 1.508E-11 1.133E-8 8.943E-8 2.266E-8 3 4
3 22202164 Sexually dimorphic testosterone secretion in prenatal and neonatal mice is independent of kisspeptin-Kiss1r and GnRH signaling. Pubmed 7.538E-11 3.776E-8 2.981E-7 1.133E-7 3 6
4 16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells. Pubmed 1.250E-9 4.696E-7 3.707E-6 1.878E-6 4 95
5 20301509 Isolated Gonadotropin-Releasing Hormone (GnRH) Deficiency Pubmed 1.233E-8 2.404E-6 1.898E-5 1.852E-5 3 28
6 25378170 Development of gonadotropin-releasing hormone secretion and pituitary response. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
7 23550013 Interactions between kisspeptins and neurokinin B. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
8 23011920 Morphological evidence for enhanced kisspeptin and neurokinin B signaling in the infundibular nucleus of the aging man. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
9 27558594 A kiss to set the rhythm. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
10 20816945 Impact of mutations in kisspeptin and neurokinin B signaling pathways on human reproduction. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
11 21219482 Dual phenotype kisspeptin-dopamine neurones of the rostral periventricular area of the third ventricle project to gonadotrophin-releasing hormone neurones. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
12 23825121 Developmental GnRH signaling is not required for sexual differentiation of kisspeptin neurons but is needed for maximal Kiss1 gene expression in adult females. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
13 23550003 Effects of kisspeptin on hormone secretion in humans. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
14 7958897 The nuclear receptor steroidogenic factor 1 acts at multiple levels of the reproductive axis. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
15 23928373 Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult mice. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
16 23393128 Neurokinin B causes acute GnRH secretion and repression of GnRH transcription in GT1-7 GnRH neurons. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
17 23550012 Kisspeptin and GnRH pulse generation. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
18 24824308 Evidence that insulin signalling in gonadotrophin-releasing hormone and kisspeptin neurones does not play an essential role in metabolic regulation of fertility in mice. Pubmed 2.879E-8 2.404E-6 1.898E-5 4.328E-5 2 2
19 23977290 Substance P immunoreactivity exhibits frequent colocalization with kisspeptin and neurokinin B in the human infundibular region. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
20 15665093 Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
21 25084101 Colocalization of cocaine- and amphetamine-regulated transcript with kisspeptin and neurokinin B in the human infundibular region. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
22 27507595 The interaction of fasting, caloric restriction, and diet-induced obesity with 17β-estradiol on the expression of KNDy neuropeptides and their receptors in the female mouse. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
23 20727862 The neuroendocrine basis of lactation-induced suppression of GnRH: role of kisspeptin and leptin. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
24 19840236 Kisspeptin/Gpr54-independent gonadotrophin-releasing hormone activity in Kiss1 and Gpr54 mutant mice. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
25 24937427 Impaired kisspeptin signaling decreases metabolism and promotes glucose intolerance and obesity. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
26 26862996 ERα in Tac2 Neurons Regulates Puberty Onset in Female Mice. Pubmed 8.637E-8 4.993E-6 3.941E-5 1.298E-4 2 3
27 24080944 Lack of functional GABAB receptors alters Kiss1 , Gnrh1 and Gad1 mRNA expression in the medial basal hypothalamus at postnatal day 4. Pubmed 1.727E-7 8.113E-6 6.403E-5 2.596E-4 2 4
28 22424618 Analysis of the expression of neurokinin B, kisspeptin, and their cognate receptors NK3R and KISS1R in the human female genital tract. Pubmed 1.727E-7 8.113E-6 6.403E-5 2.596E-4 2 4
29 18483150 Kisspeptin excites gonadotropin-releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Pubmed 1.727E-7 8.113E-6 6.403E-5 2.596E-4 2 4
30 25591470 Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin. Pubmed 1.727E-7 8.113E-6 6.403E-5 2.596E-4 2 4
31 7659091 The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus. Pubmed 1.727E-7 8.113E-6 6.403E-5 2.596E-4 2 4
32 24599473 Murine arcuate nucleus kisspeptin neurons communicate with GnRH neurons in utero. Pubmed 1.727E-7 8.113E-6 6.403E-5 2.596E-4 2 4
33 25392497 Sexual differentiation of the brain requires perinatal kisspeptin-GnRH neuron signaling. Pubmed 2.879E-7 1.202E-5 9.486E-5 4.327E-4 2 5
34 23744642 Regulation of arcuate neurons coexpressing kisspeptin, neurokinin B, and dynorphin by modulators of neurokinin 3 and κ-opioid receptors in adult male mice. Pubmed 2.879E-7 1.202E-5 9.486E-5 4.327E-4 2 5
35 26172029 In Utero Development of Kisspeptin/GnRH Neural Circuitry in Male Mice. Pubmed 2.879E-7 1.202E-5 9.486E-5 4.327E-4 2 5
36 19776272 Regulation of gonadotropin-releasing hormone secretion by kisspeptin/dynorphin/neurokinin B neurons in the arcuate nucleus of the mouse. Pubmed 2.879E-7 1.202E-5 9.486E-5 4.327E-4 2 5
37 21596839 Reproductive dysfunction and decreased GnRH neurogenesis in a mouse model of CHARGE syndrome. Pubmed 1.036E-6 4.208E-5 3.321E-4 1.557E-3 2 9
38 20805495 Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis. Pubmed 1.582E-6 6.259E-5 4.940E-4 2.378E-3 2 11
39 29263200 WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome. Pubmed 1.899E-6 7.317E-5 5.775E-4 2.854E-3 2 12
40 21074524 Differential requirements for neurogenin 3 in the development of POMC and NPY neurons in the hypothalamus. Pubmed 3.911E-6 1.469E-4 1.160E-3 5.878E-3 2 17
41 16469766 Mash1 is required for generic and subtype differentiation of hypothalamic neuroendocrine cells. Pubmed 5.462E-6 2.002E-4 1.580E-3 8.210E-3 2 20
42 27578785 The LIM-homeobox transcription factor Isl1 plays crucial roles in the development of multiple arcuate nucleus neurons. Pubmed 7.932E-6 2.838E-4 2.240E-3 1.192E-2 2 24
43 28706241 Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Pubmed 8.621E-6 3.013E-4 2.378E-3 1.296E-2 2 25
44 22945632 SOX2 regulates the hypothalamic-pituitary axis at multiple levels. Pubmed 9.338E-6 3.190E-4 2.518E-3 1.404E-2 2 26
45 18391535 WT1-mediated gene regulation in early urogenital ridge development. Pubmed 1.516E-5 4.733E-4 3.736E-3 2.279E-2 2 33
46 19086053 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. Pubmed 1.657E-5 4.733E-4 3.736E-3 2.490E-2 3 301
47 11356665 A novel transgenic model to characterize the specific effects of follicle-stimulating hormone on gonadal physiology in the absence of luteinizing hormone actions. Pubmed 1.833E-4 4.733E-4 3.736E-3
2.755E-1
 1 1
48 23145030 Elevated expression of KiSS-1 in placenta of Chinese women with early-onset preeclampsia. Pubmed 1.833E-4 4.733E-4 3.736E-3
2.755E-1
 1 1
49 6816887 Characterization of the pituitary gonadotroph cells of hypogonadal (hpg) male mice: comparison with normal mice. Pubmed 1.833E-4 4.733E-4 3.736E-3
2.755E-1
 1 1
50 15317475 Three dimensional structure of mammalian tachykinin peptide neurokinin B bound to lipid micelles. Pubmed 1.833E-4 4.733E-4 3.736E-3
2.755E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 143 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ZNF653 ZNF653 interactions 6.778E-4 2.422E-2
1.343E-1
9.692E-2
 1 2
2 int:PRLH PRLH interactions 6.778E-4 2.422E-2
1.343E-1
9.692E-2
 1 2
3 int:TBX19 TBX19 interactions 6.778E-4 2.422E-2
1.343E-1
9.692E-2
 1 2
4 int:MMP24 MMP24 interactions 6.778E-4 2.422E-2
1.343E-1
9.692E-2
 1 2
5 int:KISS1R KISS1R interactions 1.694E-3 2.422E-2
1.343E-1
2.422E-1
 1 5
6 int:TACR3 TACR3 interactions 1.694E-3 2.422E-2
1.343E-1
2.422E-1
 1 5
7 int:PRLHR PRLHR interactions 1.694E-3 2.422E-2
1.343E-1
2.422E-1
 1 5
8 int:TACR2 TACR2 interactions 1.694E-3 2.422E-2
1.343E-1
2.422E-1
 1 5
9 int:MMP16 MMP16 interactions 1.694E-3 2.422E-2
1.343E-1
2.422E-1
 1 5
10 int:GNRHR GNRHR interactions 1.694E-3 2.422E-2
1.343E-1
2.422E-1
 1 5
11 int:LHB LHB interactions 2.370E-3 2.825E-2
1.566E-1
3.390E-1
 1 7
12 int:DAZL DAZL interactions 2.370E-3 2.825E-2
1.566E-1
3.390E-1
 1 7
13 int:KISS1 KISS1 interactions 2.709E-3 2.980E-2
1.652E-1
3.873E-1
 1 8
14 int:PIN1 PIN1 interactions 2.984E-3 3.025E-2
1.677E-1
4.267E-1
 2 255
15 int:TAC3 TAC3 interactions 3.385E-3 3.025E-2
1.677E-1
4.840E-1
 1 10
16 int:GNRH1 GNRH1 interactions 3.385E-3 3.025E-2
1.677E-1
4.840E-1
 1 10
17 int:DAZ1 DAZ1 interactions 3.723E-3 3.132E-2
1.736E-1
5.324E-1
 1 11
18 int:TRERF1 TRERF1 interactions 4.399E-3 3.494E-2
1.937E-1
6.290E-1
 1 13
19 int:TRIAP1 TRIAP1 interactions 5.074E-3 3.694E-2
2.048E-1
7.256E-1
 1 15
20 int:ATOX1 ATOX1 interactions 5.411E-3 3.694E-2
2.048E-1
7.738E-1
 1 16
21 int:SH3BGRL SH3BGRL interactions 5.749E-3 3.694E-2
2.048E-1
8.221E-1
 1 17
22 int:ADK ADK interactions 6.086E-3 3.694E-2
2.048E-1
8.703E-1
 1 18
23 int:MPI MPI interactions 7.097E-3 3.694E-2
2.048E-1
1.000E0
 1 21
24 int:PNRC2 PNRC2 interactions 7.434E-3 3.694E-2
2.048E-1
1.000E0
 1 22
25 int:SOX8 SOX8 interactions 7.771E-3 3.694E-2
2.048E-1
1.000E0
 1 23
26 int:PROX1 PROX1 interactions 7.771E-3 3.694E-2
2.048E-1
1.000E0
 1 23
27 int:MEP1A MEP1A interactions 7.771E-3 3.694E-2
2.048E-1
1.000E0
 1 23
28 int:SOX9 SOX9 interactions 8.781E-3 3.694E-2
2.048E-1
1.000E0
 1 26
29 int:RAD54L2 RAD54L2 interactions 8.781E-3 3.694E-2
2.048E-1
1.000E0
 1 26
30 int:MMP14 MMP14 interactions 9.454E-3 3.694E-2
2.048E-1
1.000E0
 1 28
31 int:SNX12 SNX12 interactions 9.454E-3 3.694E-2
2.048E-1
1.000E0
 1 28
32 int:AKR1A1 AKR1A1 interactions 9.790E-3 3.694E-2
2.048E-1
1.000E0
 1 29
33 int:FAHD1 FAHD1 interactions 9.790E-3 3.694E-2
2.048E-1
1.000E0
 1 29
34 int:CARHSP1 CARHSP1 interactions 1.013E-2 3.694E-2
2.048E-1
1.000E0
 1 30
35 int:NQO1 NQO1 interactions 1.046E-2 3.694E-2
2.048E-1
1.000E0
 1 31
36 int:CUL4B CUL4B interactions 1.048E-2 3.694E-2
2.048E-1
1.000E0
 2 486
37 int:CCDC90B CCDC90B interactions 1.080E-2 3.694E-2
2.048E-1
1.000E0
 1 32
38 int:CAPG CAPG interactions 1.080E-2 3.694E-2
2.048E-1
1.000E0
 1 32
39 int:EMC4 EMC4 interactions 1.113E-2 3.694E-2
2.048E-1
1.000E0
 1 33
40 int:PITX1 PITX1 interactions 1.147E-2 3.694E-2
2.048E-1
1.000E0
 1 34
41 int:NR0B1 NR0B1 interactions 1.147E-2 3.694E-2
2.048E-1
1.000E0
 1 34
42 int:MALSU1 MALSU1 interactions 1.147E-2 3.694E-2
2.048E-1
1.000E0
 1 34
43 int:EMC8 EMC8 interactions 1.181E-2 3.694E-2
2.048E-1
1.000E0
 1 35
44 int:EDF1 EDF1 interactions 1.181E-2 3.694E-2
2.048E-1
1.000E0
 1 35
45 int:TRIM68 TRIM68 interactions 1.181E-2 3.694E-2
2.048E-1
1.000E0
 1 35
46 int:RSU1 RSU1 interactions 1.214E-2 3.694E-2
2.048E-1
1.000E0
 1 36
47 int:AASDHPPT AASDHPPT interactions 1.214E-2 3.694E-2
2.048E-1
1.000E0
 1 36
48 int:GLOD4 GLOD4 interactions 1.315E-2 3.719E-2
2.061E-1
1.000E0
 1 39
49 int:GATA4 GATA4 interactions 1.348E-2 3.719E-2
2.061E-1
1.000E0
 1 40
50 int:TRAPPC2 TRAPPC2 interactions 1.348E-2 3.719E-2
2.061E-1
1.000E0
 1 40
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q13-q21 12q13-q21 4.039E-4 2.120E-3 5.497E-3 2.827E-3 1 2
2 8p21-p11.2 8p21-p11.2 6.058E-4 2.120E-3 5.497E-3 4.240E-3 1 3
3 9q33 9q33 1.615E-3 3.531E-3 9.157E-3 1.130E-2 1 8
4 1q12 1q12 2.018E-3 3.531E-3 9.157E-3 1.413E-2 1 10
5 10q26.13 10q26.13 8.252E-3 1.150E-2 2.981E-2
5.776E-2
 1 41
6 1q32 1q32 9.855E-3 1.150E-2 2.981E-2
6.898E-2
 1 49
7 19p13.3 19p13.3 4.883E-2 4.883E-2
1.266E-1
3.418E-1
 1 247
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 36 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$LXR DR4 Q3 V$LXR DR4 Q3 8.324E-4 2.997E-2
1.251E-1
 2.997E-2 2 74

12: Gene Family [Display Chart] 7 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 542 Endogenous ligands genenames.org 7.349E-5 3.675E-4 8.391E-4 3.675E-4 3 237
2 227 Gonadotropin releasing hormone receptors genenames.org 7.694E-4 1.923E-3 4.392E-3 3.847E-3 1 2
3 220 Peptide receptors genenames.org 2.691E-3 4.484E-3 1.024E-2 1.345E-2 1 7
4 71 Nuclear hormone receptors genenames.org 1.870E-2 2.338E-2
5.338E-2
9.352E-2
 1 49

13: Coexpression [Display Chart] 7 input genes in category / 243 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M1820 Genes central for female fertility pathways, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.173E-5 7.711E-3 4.682E-2 7.711E-3 2 29

14: Coexpression Atlas [Display Chart] 7 input genes in category / 296 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 13 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9592 GNF2 IGFBP1 Neighborhood of IGFBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.057E-5 9.049E-4 2.878E-3 9.174E-4 2 35
2 M14039 GNF2 KISS1 Neighborhood of KISS1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.392E-4 9.049E-4 2.878E-3 1.810E-3 2 49
3 M14550 GNF2 CDKN1C Neighborhood of CDKN1C MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.072E-2 3.300E-2
1.050E-1
1.393E-1
 1 27
4 M7693 MODULE 500 Genes in the cancer module 500. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.190E-2 3.300E-2
1.050E-1
1.548E-1
 1 30
5 M4193 GNF2 EGFR Neighborhood of EGFR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.269E-2 3.300E-2
1.050E-1
1.650E-1
 1 32
6 M989 GNF2 MMP11 Neighborhood of MMP11 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.664E-2 3.382E-2
1.075E-1
2.163E-1
 1 42
7 M18883 GNF2 TIMP2 Neighborhood of TIMP2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.821E-2 3.382E-2
1.075E-1
2.367E-1
 1 46
8 M280 MODULE 322 Genes in the cancer module 322. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.331E-2 3.788E-2
1.205E-1
3.030E-1
 1 59
Show 3 more annotations

16: MicroRNA [Display Chart] 7 input genes in category / 97 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-521:mirSVR highEffct hsa-miR-521:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.272E-4 1.107E-2
5.710E-2
 1.234E-2 2 179
2 CAGCTTT,MIR-320:MSigDB CAGCTTT,MIR-320:MSigDB MSigDB 2.283E-4 1.107E-2
5.710E-2
 2.214E-2 2 240
3 hsa-miR-371-3p:PITA hsa-miR-371-3p:PITA TOP PITA 1.356E-3 4.141E-2
2.136E-1
1.315E-1
 1 14
4 hsa-miR-521:PITA hsa-miR-521:PITA TOP PITA 2.710E-3 4.141E-2
2.136E-1
2.629E-1
 1 28
5 hsa-miR-6877-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.739E-3 4.141E-2
2.136E-1
4.596E-1
 1 49
6 hsa-miR-8075:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.835E-3 4.141E-2
2.136E-1
4.690E-1
 1 50
7 hsa-miR-193a-5p:Functional MTI Functional MTI miRTarbase 5.510E-3 4.141E-2
2.136E-1
5.345E-1
 1 57
8 GTTAAAG,MIR-302B:MSigDB GTTAAAG,MIR-302B:MSigDB MSigDB 6.282E-3 4.141E-2
2.136E-1
6.093E-1
 1 65
9 hsa-miR-6505-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.534E-3 4.141E-2
2.136E-1
7.308E-1
 1 78
10 TCTGGAC,MIR-198:MSigDB TCTGGAC,MIR-198:MSigDB MSigDB 7.823E-3 4.141E-2
2.136E-1
7.588E-1
 1 81
11 hsa-miR-378g:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.141E-2
2.136E-1
7.681E-1
 1 82
12 hsa-miR-6781-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.400E-3 4.141E-2
2.136E-1
8.148E-1
 1 87
13 hsa-miR-4670-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 4.141E-2
2.136E-1
8.335E-1
 1 89
14 hsa-miR-523:mirSVR lowEffct hsa-miR-523:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.169E-3 4.141E-2
2.136E-1
8.894E-1
 1 95
15 TGAGATT,MIR-216:MSigDB TGAGATT,MIR-216:MSigDB MSigDB 9.746E-3 4.141E-2
2.136E-1
9.454E-1
 1 101
16 hsa-miR-4457:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.061E-2 4.141E-2
2.136E-1
1.000E0
 1 110
17 hsa-miR-720:mirSVR highEffct hsa-miR-720:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.071E-2 4.141E-2
2.136E-1
1.000E0
 1 111
18 hsa-miR-125b-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.080E-2 4.141E-2
2.136E-1
1.000E0
 1 112
19 hsa-miR-3925-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.128E-2 4.141E-2
2.136E-1
1.000E0
 1 117
20 ACAGGGT,MIR-10A:MSigDB ACAGGGT,MIR-10A:MSigDB MSigDB 1.157E-2 4.141E-2
2.136E-1
1.000E0
 1 120
21 ACAGGGT,MIR-10B:MSigDB ACAGGGT,MIR-10B:MSigDB MSigDB 1.157E-2 4.141E-2
2.136E-1
1.000E0
 1 120
22 hsa-miR-3123:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.215E-2 4.141E-2
2.136E-1
1.000E0
 1 126
23 GACAATC,MIR-219:MSigDB GACAATC,MIR-219:MSigDB MSigDB 1.291E-2 4.141E-2
2.136E-1
1.000E0
 1 134
24 hsa-miR-4486:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.358E-2 4.141E-2
2.136E-1
1.000E0
 1 141
25 hsa-miR-513b-5p:Functional MTI Functional MTI miRTarbase 1.387E-2 4.141E-2
2.136E-1
1.000E0
 1 144
26 hsa-miR-198:PITA hsa-miR-198:PITA TOP PITA 1.435E-2 4.141E-2
2.136E-1
1.000E0
 1 149
27 hsa-miR-1274b:PITA hsa-miR-1274b:PITA TOP PITA 1.607E-2 4.141E-2
2.136E-1
1.000E0
 1 167
28 hsa-miR-136*:mirSVR highEffct hsa-miR-136*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.617E-2 4.141E-2
2.136E-1
1.000E0
 1 168
29 hsa-miR-219-5p:PITA hsa-miR-219-5p:PITA TOP PITA 1.655E-2 4.141E-2
2.136E-1
1.000E0
 1 172
30 hsa-miR-10a:PITA hsa-miR-10a:PITA TOP PITA 1.664E-2 4.141E-2
2.136E-1
1.000E0
 1 173
31 hsa-miR-10b:PITA hsa-miR-10b:PITA TOP PITA 1.664E-2 4.141E-2
2.136E-1
1.000E0
 1 173
32 hsa-miR-1825:PITA hsa-miR-1825:PITA TOP PITA 1.750E-2 4.141E-2
2.136E-1
1.000E0
 1 182
33 hsa-miR-575:PITA hsa-miR-575:PITA TOP PITA 1.808E-2 4.141E-2
2.136E-1
1.000E0
 1 188
34 hsa-miR-1303:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.932E-2 4.141E-2
2.136E-1
1.000E0
 1 201
35 hsa-miR-614:mirSVR highEffct hsa-miR-614:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.970E-2 4.141E-2
2.136E-1
1.000E0
 1 205
36 hsa-miR-4313:mirSVR highEffct hsa-miR-4313:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.131E-2 4.141E-2
2.136E-1
1.000E0
 1 222
37 hsa-miR-1343-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.141E-2 4.141E-2
2.136E-1
1.000E0
 1 223
38 hsa-miR-6783-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.141E-2 4.141E-2
2.136E-1
1.000E0
 1 223
39 hsa-miR-24:PITA hsa-miR-24:PITA TOP PITA 2.141E-2 4.141E-2
2.136E-1
1.000E0
 1 223
40 hsa-miR-6852-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.189E-2 4.141E-2
2.136E-1
1.000E0
 1 228
41 ATGTTAA,MIR-302C:MSigDB ATGTTAA,MIR-302C:MSigDB MSigDB 2.227E-2 4.141E-2
2.136E-1
1.000E0
 1 232
42 hsa-miR-10b-5p:TargetScan hsa-miR-10b-5p TargetScan 2.341E-2 4.141E-2
2.136E-1
1.000E0
 1 244
43 hsa-miR-10a-5p:TargetScan hsa-miR-10a-5p TargetScan 2.341E-2 4.141E-2
2.136E-1
1.000E0
 1 244
44 hsa-miR-3187-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.445E-2 4.141E-2
2.136E-1
1.000E0
 1 255
45 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 2.454E-2 4.141E-2
2.136E-1
1.000E0
 1 256
46 hsa-miR-5189-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.464E-2 4.141E-2
2.136E-1
1.000E0
 1 257
47 hsa-miR-582-3p:PITA hsa-miR-582-3p:PITA TOP PITA 2.473E-2 4.141E-2
2.136E-1
1.000E0
 1 258
48 hsa-miR-612:Non-Functional MTI Non-Functional MTI miRTarbase 2.473E-2 4.141E-2
2.136E-1
1.000E0
 1 258
49 hsa-miR-6860:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.473E-2 4.141E-2
2.136E-1
1.000E0
 1 258
50 hsa-miR-1285-3p:Functional MTI Functional MTI miRTarbase 2.483E-2 4.141E-2
2.136E-1
1.000E0
 1 259
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 1476 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C419153 1,3,5-tris(4-hydroxyphenyl)-4-propyl-1H-pyrazole CTD 2.047E-6 1.662E-3 1.309E-2 3.021E-3 3 90
2 ctd:C032739 aroclor 1221 CTD 2.252E-6 1.662E-3 1.309E-2 3.324E-3 2 8
3 CID000001356 AC1L1BAN Stitch 4.422E-6 2.176E-3 1.713E-2 6.527E-3 2 11
4 CID003035449 Met-kallidin Stitch 2.607E-5 9.621E-3
7.576E-2
 3.848E-2 2 26
5 CID000036523 Factrel Stitch 4.184E-5 1.235E-2
9.725E-2
6.175E-2
 3 246
6 CID000004425 EN-1530 Stitch 6.021E-5 1.475E-2
1.161E-1
8.887E-2
 3 278
7 CID005311023 BIBP3226 Stitch 7.569E-5 1.475E-2
1.161E-1
1.117E-1
 2 44
8 CID000055583 beta-Neurokinin Stitch 9.793E-5 1.475E-2
1.161E-1
1.445E-1
 2 50
9 CID004476950 Nchembio861-comp5 Stitch 1.060E-4 1.475E-2
1.161E-1
1.564E-1
 2 52
10 CID000122185 Rfamide Stitch 1.230E-4 1.475E-2
1.161E-1
1.816E-1
 2 56
11 CID005288578 hydron;propane-1,3-diol Stitch 1.320E-4 1.475E-2
1.161E-1
1.948E-1
 2 58
12 CID003035490 MesG Stitch 1.320E-4 1.475E-2
1.161E-1
1.948E-1
 2 58
13 CID000005753 corticosterone Stitch 1.533E-4 1.475E-2
1.161E-1
2.263E-1
 3 381
14 CID000025476 Hypertensin II Stitch 2.177E-4 1.475E-2
1.161E-1
3.213E-1
 3 429
15 CID000194869 3'(Bz2)2'd epsilon ADP Stitch 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
16 CID000063106 PCB51 Stitch 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
17 DB04752 Phosphatidyl ethanol Drug Bank 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
18 CID000093418 CR144 Stitch 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
19 DB04683 (2R)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(9E)-HEXADEC-9-ENOYLOXY]PROPYL (9E)-OCTADEC-9-ENOATE Drug Bank 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
20 CID000027624 megazone Stitch 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
21 CID000150785 15-hydroxyprogesterone Stitch 3.065E-4 1.475E-2
1.161E-1
4.523E-1
 1 1
22 ctd:C074283 estradiol 3-benzoate CTD 3.113E-4 1.475E-2
1.161E-1
4.595E-1
 2 89
23 CID000444764 2-(oxalylamino)benzoic acid Stitch 3.113E-4 1.475E-2
1.161E-1
4.595E-1
 2 89
24 CID000003903 Leucine enkephalin Stitch 4.665E-4 1.475E-2
1.161E-1
6.886E-1
 2 109
25 CID000006166 deoxycorticosterone Stitch 4.837E-4 1.475E-2
1.161E-1
7.140E-1
 2 111
26 CID000000490 phosphonoacetaldehyde Stitch 4.925E-4 1.475E-2
1.161E-1
7.269E-1
 2 112
27 CID000004768 phenoxybenzamine Stitch 5.191E-4 1.475E-2
1.161E-1
7.662E-1
 2 115
28 CID000024411 oxovanadium Stitch 5.650E-4 1.475E-2
1.161E-1
8.339E-1
 2 120
29 CID000042785 Lupex Stitch 6.031E-4 1.475E-2
1.161E-1
8.902E-1
 2 124
30 CID000134628 5-androstane-3beta,17beta-diol Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
31 CID011337569 CHEBI:396442 Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
32 CID000121658 glyceryl monobehenate Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
33 CID000087014 2-(hydroxymethyl)anthraquinone Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
34 DB00666 Nafarelin Drug Bank 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
35 CID009589394 EH-NX Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
36 CID000050463 diproteverine Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
37 CID000197015 acetomepregenol Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
38 CID003081547 Hyp(9)-lhrh Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
39 CID000116217 D 287 Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
40 CID006434697 delprostenate Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
41 CID003086519 AC1MJ6C7 Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
42 CID003081500 AC1MIX1Q Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
43 DB00644 Gonadorelin Drug Bank 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
44 CID009794344 5-iodovaleraldehyde Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
45 CID000204099 diallyl G Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
46 CID000168847 16 beta-OH DHEA sulfate Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
47 CID003035637 N- and P Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
48 CID000173627 5,6-dihydroxytryptophan Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
49 ctd:D012722 Sewage CTD 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
50 CID003081299 Protactin Stitch 6.129E-4 1.475E-2
1.161E-1
9.046E-1
 1 2
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 209 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1860121 Decreased testosterone in males DisGeNET Curated 2.486E-10 5.196E-8 3.077E-7 5.196E-8 4 28
2 C0232939 Primary physiologic amenorrhea DisGeNET Curated 8.702E-9 4.041E-7 2.393E-6 1.819E-6 4 66
3 C4021107 Non-obstructive azoospermia DisGeNET Curated 1.043E-8 4.041E-7 2.393E-6 2.181E-6 4 69
4 C0018418 Gynecomastia DisGeNET Curated 1.241E-8 4.041E-7 2.393E-6 2.594E-6 4 72
5 C4025901 Abnormality of body height DisGeNET Curated 1.409E-8 4.041E-7 2.393E-6 2.945E-6 3 13
6 C4022675 Increased female libido DisGeNET Curated 1.409E-8 4.041E-7 2.393E-6 2.945E-6 3 13
7 C0022735 Klinefelter Syndrome DisGeNET BeFree 1.466E-8 4.041E-7 2.393E-6 3.063E-6 4 75
8 C0241355 Small testicle DisGeNET Curated 1.547E-8 4.041E-7 2.393E-6 3.233E-6 4 76
9 C4025569 Eunuchoid habitus DisGeNET Curated 1.793E-8 4.164E-7 2.466E-6 3.747E-6 3 14
10 C3489396 Hypogonadism, Isolated Hypogonadotropic DisGeNET Curated 3.074E-8 6.217E-7 3.681E-6 6.425E-6 4 90
11 C1846228 Absence of pubertal development DisGeNET Curated 3.348E-8 6.217E-7 3.681E-6 6.997E-6 3 17
12 C1563720 Kallmann Syndrome 2 (disorder) DisGeNET Curated 4.016E-8 6.217E-7 3.681E-6 8.394E-6 3 18
13 C0271578 Female hypogonadism syndrome DisGeNET Curated 4.016E-8 6.217E-7 3.681E-6 8.394E-6 3 18
14 C0034012 Delayed Puberty DisGeNET Curated 4.164E-8 6.217E-7 3.681E-6 8.703E-6 4 97
15 C0271623 Hypogonadotropic hypogonadism DisGeNET Curated 4.711E-8 6.563E-7 3.887E-6 9.845E-6 4 100
16 C0747078 Generalized osteopenia DisGeNET Curated 5.104E-8 6.666E-7 3.948E-6 1.067E-5 4 102
17 C4021551 Absence of secondary sex characteristics DisGeNET Curated 7.574E-8 9.312E-7 5.515E-6 1.583E-5 3 22
18 C0266399 Infantile uterus DisGeNET Curated 8.709E-8 9.580E-7 5.673E-6 1.820E-5 3 23
19 OMIN:146110 HYPOGONADOTROPIC HYPOGONADISM OMIM 8.709E-8 9.580E-7 5.673E-6 1.820E-5 3 23
20 C0266013 Congenital hypoplasia of breast DisGeNET Curated 1.278E-7 1.335E-6 7.908E-6 2.671E-5 3 26
21 C0541764 Delayed bone age DisGeNET Curated 1.629E-7 1.621E-6 9.601E-6 3.405E-5 4 136
22 C0151721 Testicular hypogonadism DisGeNET Curated 1.994E-7 1.667E-6 9.871E-6 4.167E-5 3 30
23 C0232940 Secondary physiologic amenorrhea DisGeNET Curated 1.994E-7 1.667E-6 9.871E-6 4.167E-5 3 30
24 C0685840 Congenital hypoplasia of ovary DisGeNET Curated 1.994E-7 1.667E-6 9.871E-6 4.167E-5 3 30
25 C1835452 Hypoplastic ovary DisGeNET Curated 1.994E-7 1.667E-6 9.871E-6 4.167E-5 3 30
26 C0342384 Idiopathic hypogonadotropic hypogonadism DisGeNET Curated 2.207E-7 1.774E-6 1.051E-5 4.613E-5 3 31
27 C1862863 Sparse body hair DisGeNET Curated 2.435E-7 1.885E-6 1.116E-5 5.089E-5 3 32
28 C0747102 Ovarian failure DisGeNET BeFree 4.843E-7 3.615E-6 2.141E-5 1.012E-4 3 40
29 C0266435 Congenital hypoplasia of penis DisGeNET Curated 5.483E-7 3.952E-6 2.340E-5 1.146E-4 4 184
30 C1827524 Wide spaced nipples DisGeNET Curated 7.433E-7 5.011E-6 2.968E-5 1.553E-4 3 46
31 C4021776 Abnormality of the voice DisGeNET Curated 7.433E-7 5.011E-6 2.968E-5 1.553E-4 3 46
32 C0029453 Osteopenia DisGeNET Curated 2.768E-6 1.808E-5 1.071E-4 5.785E-4 4 276
33 C0023267 Fibroid Tumor DisGeNET Curated 3.279E-6 2.077E-5 1.230E-4 6.853E-4 4 288
34 C0010417 Cryptorchidism DisGeNET Curated 3.857E-6 2.371E-5 1.404E-4 8.061E-4 4 300
35 C0242350 Erectile dysfunction DisGeNET Curated 4.633E-6 2.766E-5 1.638E-4 9.683E-4 3 84
36 C0342543 Precocious Puberty, Central DisGeNET Curated 5.750E-6 3.338E-5 1.977E-4 1.202E-3 2 9
37 C0042133 Uterine Fibroids DisGeNET Curated 6.565E-6 3.708E-5 2.196E-4 1.372E-3 4 343
38 C3899503 Congenital Hypogonadotropic Hypogonadism DisGeNET BeFree 7.186E-6 3.952E-5 2.340E-4 1.502E-3 2 10
39 C0029456 Osteoporosis DisGeNET Curated 9.447E-6 5.063E-5 2.998E-4 1.974E-3 4 376
40 C4020884 Anxiety disease DisGeNET Curated 1.391E-5 7.266E-5 4.303E-4 2.906E-3 3 121
41 C0003467 Anxiety DisGeNET Curated 1.636E-5 8.338E-5 4.938E-4 3.419E-3 4 432
42 C0020619 Hypogonadism DisGeNET Curated 2.154E-5 1.072E-4 6.347E-4 4.501E-3 3 140
43 C0220748 Cartilage-hair hypoplasia DisGeNET Curated 5.585E-5 2.715E-4 1.608E-3 1.167E-2 2 27
44 C1858574 Sparse axillary hair DisGeNET Curated 6.014E-5 2.857E-4 1.692E-3 1.257E-2 2 28
45 C1858573 Sparse pubic hair DisGeNET Curated 7.393E-5 3.434E-4 2.033E-3 1.545E-2 2 31
46 C0001623 Adrenal gland hypofunction DisGeNET Curated 7.885E-5 3.582E-4 2.121E-3 1.648E-2 2 32
47 C0405580 Adrenal cortical hypofunction DisGeNET Curated 1.116E-4 4.963E-4 2.939E-3 2.333E-2 2 38
48 C0032000 Pituitary Adenoma DisGeNET Curated 1.769E-4 7.704E-4 4.563E-3 3.698E-2 3 284
49 C0034013 Precocious Puberty DisGeNET Curated 1.940E-4 8.275E-4 4.900E-3 4.055E-2 2 50
50 C1384514 Conn Syndrome DisGeNET BeFree 2.524E-4 1.055E-3 6.248E-3
5.275E-2
 2 57
Show 45 more annotations