Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc12_21, positive side

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1: GO: Molecular Function [Display Chart] 21 input genes in category / 10 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005200 structural constituent of cytoskeleton 1.226E-7 1.226E-6 3.590E-6 1.226E-6 5 110
2 GO:0097110 scaffold protein binding 3.103E-5 1.552E-4 4.545E-4 3.103E-4 3 55
3 GO:1990254 keratin filament binding 5.615E-3 1.404E-2 4.111E-2
5.615E-2
 1 5
4 GO:0042289 MHC class II protein binding 5.615E-3 1.404E-2 4.111E-2
5.615E-2
 1 5
5 GO:0030280 structural constituent of epidermis 8.969E-3 1.794E-2
5.254E-2
8.969E-2
 1 8
6 GO:0032395 MHC class II receptor activity 1.342E-2 2.237E-2
6.553E-2
1.342E-1
 1 12
7 GO:0019215 intermediate filament binding 1.786E-2 2.552E-2
7.474E-2
1.786E-1
 1 16
8 GO:0042287 MHC protein binding 3.433E-2 4.291E-2
1.257E-1
3.433E-1
 1 31
Show 3 more annotations

2: GO: Biological Process [Display Chart] 19 input genes in category / 133 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0045104 intermediate filament cytoskeleton organization 1.454E-14 1.139E-12 6.235E-12 1.933E-12 7 45
2 GO:0045103 intermediate filament-based process 1.714E-14 1.139E-12 6.235E-12 2.279E-12 7 46
3 GO:0008544 epidermis development 2.653E-8 1.176E-6 6.435E-6 3.528E-6 7 340
4 GO:0042303 molting cycle 5.897E-6 1.569E-4 8.582E-4 7.843E-4 4 120
5 GO:0042633 hair cycle 5.897E-6 1.569E-4 8.582E-4 7.843E-4 4 120
6 GO:0031581 hemidesmosome assembly 6.469E-5 1.434E-3 7.846E-3 8.604E-3 2 12
7 GO:0097284 hepatocyte apoptotic process 1.027E-4 1.952E-3 1.068E-2 1.366E-2 2 15
8 GO:0043588 skin development 1.578E-4 2.624E-3 1.436E-2 2.099E-2 4 278
9 GO:0061436 establishment of skin barrier 2.047E-4 2.723E-3 1.490E-2 2.723E-2 2 21
10 GO:0045109 intermediate filament organization 2.047E-4 2.723E-3 1.490E-2 2.723E-2 2 21
11 GO:0033561 regulation of water loss via skin 2.917E-4 3.527E-3 1.930E-2 3.880E-2 2 25
12 GO:0030216 keratinocyte differentiation 3.537E-4 3.920E-3 2.145E-2 4.704E-2 3 138
13 GO:0060706 cell differentiation involved in embryonic placenta development 4.217E-4 4.315E-3 2.361E-2
5.609E-2
 2 30
14 GO:0045214 sarcomere organization 7.516E-4 7.140E-3 3.907E-2
9.997E-2
 2 40
15 GO:0009913 epidermal cell differentiation 1.041E-3 9.234E-3
5.052E-2
1.385E-1
 3 200
16 GO:0031424 keratinization 1.317E-3 1.095E-2
5.992E-2
1.752E-1
 2 53
17 GO:0030239 myofibril assembly 1.741E-3 1.362E-2
7.453E-2
2.316E-1
 2 61
18 GO:0050891 multicellular organismal water homeostasis 2.035E-3 1.428E-2
7.811E-2
2.706E-1
 2 66
19 GO:0043000 Golgi to plasma membrane CFTR protein transport 2.040E-3 1.428E-2
7.811E-2
2.713E-1
 1 2
20 GO:0030104 water homeostasis 2.899E-3 1.928E-2
1.055E-1
3.856E-1
 2 79
21 GO:0007568 aging 3.567E-3 2.214E-2
1.212E-1
4.744E-1
 3 308
22 GO:0007044 cell-substrate junction assembly 3.663E-3 2.214E-2
1.212E-1
4.872E-1
 2 89
23 GO:1904019 epithelial cell apoptotic process 4.422E-3 2.499E-2
1.367E-1
5.881E-1
 2 98
24 GO:0001892 embryonic placenta development 4.510E-3 2.499E-2
1.367E-1
5.998E-1
 2 99
25 GO:0045110 intermediate filament bundle assembly 6.107E-3 3.249E-2
1.777E-1
8.122E-1
 1 6
26 GO:0051599 response to hydrostatic pressure 7.121E-3 3.643E-2
1.993E-1
9.471E-1
 1 7
27 GO:0001867 complement activation, lectin pathway 9.147E-3 4.506E-2
2.465E-1
1.000E0
 1 9
28 GO:0051798 positive regulation of hair follicle development 1.016E-2 4.642E-2
2.540E-1
1.000E0
 1 10
29 GO:0033209 tumor necrosis factor-mediated signaling pathway 1.073E-2 4.642E-2
2.540E-1
1.000E0
 2 155
30 GO:0043587 tongue morphogenesis 1.117E-2 4.642E-2
2.540E-1
1.000E0
 1 11
31 GO:0061303 cornea development in camera-type eye 1.117E-2 4.642E-2
2.540E-1
1.000E0
 1 11
32 GO:0042635 positive regulation of hair cycle 1.117E-2 4.642E-2
2.540E-1
1.000E0
 1 11
33 GO:0031032 actomyosin structure organization 1.167E-2 4.646E-2
2.542E-1
1.000E0
 2 162
34 GO:0001890 placenta development 1.209E-2 4.646E-2
2.542E-1
1.000E0
 2 165
35 GO:0055002 striated muscle cell development 1.223E-2 4.646E-2
2.542E-1
1.000E0
 2 166
36 GO:0051546 keratinocyte migration 1.319E-2 4.872E-2
2.665E-1
1.000E0
 1 13
Show 31 more annotations

3: GO: Cellular Component [Display Chart] 21 input genes in category / 28 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005882 intermediate filament 1.044E-42 2.924E-41 1.148E-40 2.924E-41 21 201
2 GO:0045111 intermediate filament cytoskeleton 7.451E-41 1.043E-39 4.096E-39 2.086E-39 21 244
3 GO:0045095 keratin filament 6.352E-34 5.929E-33 2.328E-32 1.779E-32 16 94
4 GO:0043034 costamere 2.397E-4 1.230E-3 4.830E-3 6.712E-3 2 21
5 GO:0016010 dystrophin-associated glycoprotein complex 2.635E-4 1.230E-3 4.830E-3 7.379E-3 2 22
6 GO:0090665 glycoprotein complex 2.635E-4 1.230E-3 4.830E-3 7.379E-3 2 22
7 GO:1990357 terminal web 5.497E-3 2.199E-2
8.635E-2
1.539E-1
 1 5
8 GO:0030018 Z disc 7.511E-3 2.629E-2
1.032E-1
2.103E-1
 2 119
9 GO:0031674 I band 9.574E-3 2.979E-2
1.170E-1
2.681E-1
 2 135
10 GO:0042383 sarcolemma 1.201E-2 3.363E-2
1.321E-1
3.363E-1
 2 152
11 GO:0030017 sarcomere 1.980E-2 4.948E-2
1.943E-1
5.545E-1
 2 198
12 GO:0044449 contractile fiber part 2.310E-2 4.948E-2
1.943E-1
6.468E-1
 2 215
13 GO:0030016 myofibril 2.411E-2 4.948E-2
1.943E-1
6.751E-1
 2 220
14 GO:0043292 contractile fiber 2.703E-2 4.948E-2
1.943E-1
7.569E-1
 2 234
15 GO:0034451 centriolar satellite 2.720E-2 4.948E-2
1.943E-1
7.616E-1
 1 25
16 GO:0030057 desmosome 2.827E-2 4.948E-2
1.943E-1
7.916E-1
 1 26
Show 11 more annotations

4: Human Phenotype [Display Chart] 18 input genes in category / 257 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007502 Follicular hyperkeratosis 3.510E-15 9.021E-13 5.528E-12 9.021E-13 8 23
2 HP:0000962 Hyperkeratosis 4.711E-12 5.129E-10 3.143E-9 1.211E-9 12 247
3 HP:0001035 Abnormality of keratinization 5.987E-12 5.129E-10 3.143E-9 1.539E-9 12 252
4 HP:0008404 Nail dystrophy 8.356E-12 5.369E-10 3.290E-9 2.148E-9 10 133
5 HP:0010765 Palmar hyperkeratosis 3.328E-10 1.711E-8 1.048E-7 8.554E-8 7 51
6 HP:0002164 Nail dysplasia 4.754E-10 1.754E-8 1.075E-7 1.222E-7 10 199
7 HP:0007556 Plantar hyperkeratosis 5.060E-10 1.754E-8 1.075E-7 1.300E-7 7 54
8 HP:0000982 Palmoplantar keratoderma 5.461E-10 1.754E-8 1.075E-7 1.403E-7 9 140
9 HP:0011368 Epidermal thickening 1.249E-9 3.568E-8 2.186E-7 3.211E-7 12 396
10 HP:0001805 Thick nail 6.678E-9 1.716E-7 1.052E-6 1.716E-6 5 20
11 HP:0001072 Thickened skin 7.861E-9 1.837E-7 1.126E-6 2.020E-6 12 464
12 HP:0000972 Palmoplantar hyperkeratosis 1.210E-8 2.533E-7 1.552E-6 3.109E-6 6 47
13 HP:0002745 Oral leukoplakia 1.380E-8 2.533E-7 1.552E-6 3.546E-6 6 48
14 HP:0025125 White lesion of the oral mucosa 1.380E-8 2.533E-7 1.552E-6 3.546E-6 6 48
15 HP:0100872 Abnormality of the plantar skin of foot 1.981E-8 3.395E-7 2.080E-6 5.092E-6 7 90
16 HP:0001597 Abnormality of the nail 1.369E-7 2.114E-6 1.296E-5 3.518E-5 10 356
17 HP:0008066 Abnormal blistering of the skin 1.398E-7 2.114E-6 1.296E-5 3.594E-5 7 119
18 HP:0200035 Skin plaque 4.433E-7 6.008E-6 3.682E-5 1.139E-4 4 18
19 HP:0002233 Sparse, thin scalp hair 4.675E-7 6.008E-6 3.682E-5 1.202E-4 3 5
20 HP:0004779 Brittle scalp hair 4.675E-7 6.008E-6 3.682E-5 1.202E-4 3 5
21 HP:0001131 Corneal dystrophy 6.207E-7 7.596E-6 4.655E-5 1.595E-4 5 47
22 HP:0007468 Perifollicular hyperkeratosis 1.629E-6 1.902E-5 1.166E-4 4.185E-4 3 7
23 HP:0005595 Generalized hyperkeratosis 3.352E-6 3.745E-5 2.295E-4 8.614E-4 4 29
24 HP:0031285 Abnormal perifollicular morphology 3.890E-6 4.165E-5 2.553E-4 9.997E-4 3 9
25 HP:0008064 Ichthyosis 5.141E-6 5.277E-5 3.234E-4 1.321E-3 7 202
26 HP:0000206 Glossitis 5.544E-6 5.277E-5 3.234E-4 1.425E-3 3 10
27 HP:0002232 Patchy alopecia 5.544E-6 5.277E-5 3.234E-4 1.425E-3 3 10
28 HP:0025092 Epidermal acanthosis 9.144E-6 8.393E-5 5.143E-4 2.350E-3 4 37
29 HP:0040211 Abnormality of the skin of the palm 9.925E-6 8.796E-5 5.390E-4 2.551E-3 7 223
30 HP:0007494 Discrete 2 to 5-mm hyper- and hypopigmented macules 1.381E-5 1.109E-4 6.799E-4 3.550E-3 2 2
31 HP:0007530 Punctate palmoplantar hyperkeratosis 1.381E-5 1.109E-4 6.799E-4 3.550E-3 2 2
32 HP:0007438 Mottled pigmentation of the trunk and proximal extremities 1.381E-5 1.109E-4 6.799E-4 3.550E-3 2 2
33 HP:0001006 Hypotrichosis 1.896E-5 1.477E-4 9.049E-4 4.873E-3 7 246
34 HP:0007475 Congenital bullous ichthyosiform erythroderma 2.077E-5 1.570E-4 9.621E-4 5.338E-3 3 15
35 HP:0002299 Brittle hair 3.091E-5 2.270E-4 1.391E-3 7.944E-3 4 50
36 HP:0100643 Abnormality of nail color 3.698E-5 2.640E-4 1.618E-3 9.504E-3 3 18
37 HP:0007559 Localized epidermolytic hyperkeratosis 4.135E-5 2.872E-4 1.760E-3 1.063E-2 2 3
38 HP:0011124 Abnormality of epidermal morphology 5.586E-5 3.778E-4 2.315E-3 1.436E-2 4 58
39 HP:0007441 Hyperpigmented/hypopigmented macules 8.251E-5 5.172E-4 3.169E-3 2.121E-2 2 4
40 HP:0007446 Palmoplantar blistering 8.251E-5 5.172E-4 3.169E-3 2.121E-2 2 4
41 HP:0007856 Punctate opacification of the cornea 8.251E-5 5.172E-4 3.169E-3 2.121E-2 2 4
42 HP:0100871 Abnormality of the palm 8.671E-5 5.281E-4 3.236E-3 2.229E-2 7 311
43 HP:0011356 Regional abnormality of skin 8.851E-5 5.281E-4 3.236E-3 2.275E-2 7 312
44 HP:0000695 Natal tooth 9.042E-5 5.281E-4 3.236E-3 2.324E-2 3 24
45 HP:0000975 Hyperhidrosis 1.308E-4 7.471E-4 4.579E-3 3.362E-2 6 226
46 HP:0200040 Epidermoid cyst 1.450E-4 8.099E-4 4.963E-3 3.725E-2 3 28
47 HP:0002115 Sparse or absent hair 1.576E-4 8.617E-4 5.281E-3 4.050E-2 8 467
48 HP:0025245 Cutaneous cyst 1.788E-4 9.572E-4 5.866E-3 4.595E-2 3 30
49 HP:0007435 Diffuse palmoplantar keratoderma 2.053E-4 1.045E-3 6.402E-3
5.277E-2
 2 6
50 HP:0009123 Mixed hypo- and hyperpigmentation of the skin 2.053E-4 1.045E-3 6.402E-3
5.277E-2
 2 6
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 11 input genes in category / 348 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000764 abnormal tongue epithelium morphology 1.615E-8 5.620E-6 3.614E-5 5.620E-6 4 29
2 MP:0020853 abnormal corneal epithelium thickness 1.561E-6 2.717E-4 1.747E-3 5.433E-4 3 23
3 MP:0000762 abnormal tongue morphology 6.457E-6 7.490E-4 4.816E-3 2.247E-3 4 126
4 MP:0006372 impaired placental function 1.535E-5 1.114E-3 7.161E-3 5.343E-3 2 6
5 MP:0006000 abnormal corneal epithelium morphology 1.600E-5 1.114E-3 7.161E-3 5.568E-3 3 49
6 MP:0020854 increased corneal epithelium thickness 4.596E-5 2.665E-3 1.714E-2 1.599E-2 2 10
7 MP:0004259 small placenta 6.010E-5 2.689E-3 1.729E-2 2.091E-2 3 76
8 MP:0000467 abnormal esophagus morphology 6.496E-5 2.689E-3 1.729E-2 2.261E-2 3 78
9 MP:0013754 abnormal ocular surface morphology 7.273E-5 2.689E-3 1.729E-2 2.531E-2 3 81
10 MP:0005033 abnormal trophoblast giant cell morphology 8.698E-5 2.689E-3 1.729E-2 3.027E-2 3 86
11 MP:0012057 abnormal mural trophectoderm morphology 9.004E-5 2.689E-3 1.729E-2 3.133E-2 3 87
12 MP:0020855 decreased corneal epithelium thickness 9.272E-5 2.689E-3 1.729E-2 3.227E-2 2 14
13 MP:0002796 impaired skin barrier function 1.030E-4 2.756E-3 1.772E-2 3.583E-2 3 91
14 MP:0009397 increased trophoblast giant cell number 1.221E-4 2.833E-3 1.822E-2 4.250E-2 2 16
15 MP:0008959 abnormal spongiotrophoblast cell morphology 1.221E-4 2.833E-3 1.822E-2 4.250E-2 2 16
16 MP:0004258 abnormal placenta size 1.363E-4 2.965E-3 1.907E-2 4.744E-2 3 100
17 MP:0002095 abnormal skin pigmentation 2.011E-4 4.116E-3 2.647E-2
6.997E-2
 3 114
18 MP:0011239 abnormal skin coloration 2.457E-4 4.703E-3 3.024E-2
8.551E-2
 3 122
19 MP:0005028 abnormal trophectoderm morphology 2.578E-4 4.703E-3 3.024E-2
8.972E-2
 3 124
20 MP:0001242 hyperkeratosis 2.703E-4 4.703E-3 3.024E-2
9.406E-2
 3 126
21 MP:0001243 abnormal dermal layer morphology 3.100E-4 5.137E-3 3.304E-2
1.079E-1
 3 132
22 MP:0000468 abnormal esophageal epithelium morphology 3.549E-4 5.567E-3 3.580E-2
1.235E-1
 2 27
23 MP:0011203 abnormal parietal yolk sac morphology 3.923E-4 5.567E-3 3.580E-2
1.365E-1
 3 143
24 MP:0001208 blistering 4.101E-4 5.567E-3 3.580E-2
1.427E-1
 2 29
25 MP:0003413 hair follicle degeneration 4.101E-4 5.567E-3 3.580E-2
1.427E-1
 2 29
26 MP:0001216 abnormal epidermal layer morphology 4.159E-4 5.567E-3 3.580E-2
1.447E-1
 4 366
27 MP:0011194 abnormal hair follicle physiology 4.391E-4 5.660E-3 3.640E-2
1.528E-1
 2 30
28 MP:0005031 abnormal trophoblast layer morphology 4.693E-4 5.833E-3 3.751E-2
1.633E-1
 3 152
29 MP:0001240 abnormal epidermis stratum corneum morphology 6.399E-4 7.679E-3 4.938E-2
2.227E-1
 3 169
30 MP:0004381 abnormal hair follicle melanocyte morphology 7.441E-4 8.513E-3
5.475E-2
2.590E-1
 2 39
31 MP:0002051 increased skin papilloma incidence 7.828E-4 8.513E-3
5.475E-2
2.724E-1
 2 40
32 MP:0011400 lethality, complete penetrance 7.828E-4 8.513E-3
5.475E-2
2.724E-1
 2 40
33 MP:0000470 abnormal stomach morphology 9.997E-4 1.029E-2
6.619E-2
3.479E-1
 3 197
34 MP:0000351 increased cell proliferation 1.021E-3 1.029E-2
6.619E-2
3.553E-1
 4 464
35 MP:0001874 acanthosis 1.035E-3 1.029E-2
6.619E-2
3.602E-1
 2 46
36 MP:0009611 epidermis stratum spinosum hyperplasia 1.127E-3 1.072E-2
6.891E-2
3.921E-1
 2 48
37 MP:0014137 abnormal preimplantation embryo morphology 1.170E-3 1.072E-2
6.891E-2
4.072E-1
 3 208
38 MP:0004957 abnormal blastocyst morphology 1.170E-3 1.072E-2
6.891E-2
4.072E-1
 3 208
39 MP:0001186 pigmentation phenotype 1.224E-3 1.092E-2
7.024E-2
4.260E-1
 4 487
40 MP:0001200 thick skin 1.322E-3 1.150E-2
7.394E-2
4.599E-1
 2 52
41 MP:0001312 abnormal cornea morphology 1.376E-3 1.168E-2
7.511E-2
4.788E-1
 3 220
42 MP:0002014 increased papilloma incidence 1.698E-3 1.407E-2
9.050E-2
5.910E-1
 2 59
43 MP:0002074 abnormal hair texture 1.995E-3 1.607E-2
1.033E-1
6.944E-1
 2 64
44 MP:0004255 abnormal spongiotrophoblast layer morphology 2.121E-3 1.607E-2
1.033E-1
7.380E-1
 2 66
45 MP:0003780 increased lip tumor incidence 2.124E-3 1.607E-2
1.033E-1
7.390E-1
 1 2
46 MP:0009241 thick sperm flagellum 2.124E-3 1.607E-2
1.033E-1
7.390E-1
 1 2
47 MP:0008957 abnormal placenta junctional zone morphology 2.450E-3 1.814E-2
1.166E-1
8.524E-1
 2 71
48 MP:0002075 abnormal coat/hair pigmentation 2.664E-3 1.931E-2
1.242E-1
9.271E-1
 3 277
49 MP:0001192 scaly skin 2.874E-3 2.041E-2
1.313E-1
1.000E0
 2 77
50 MP:0001236 abnormal epidermis stratum spinosum morphology 2.948E-3 2.052E-2
1.320E-1
1.000E0
 2 78
Show 45 more annotations

6: Domain [Display Chart] 21 input genes in category / 20 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00226 IF PROSITE 7.507E-53 1.054E-51 3.792E-51 1.501E-51 21 72
2 PF00038 Filament Pfam 1.054E-52 1.054E-51 3.792E-51 2.108E-51 21 73
3 IPR001664 IF InterPro 2.824E-52 1.883E-51 6.774E-51 5.648E-51 21 76
4 IPR018039 Intermediate filament CS InterPro 2.447E-50 1.224E-49 4.402E-49 4.895E-49 20 63
5 SM01391 Filament SMART 4.087E-49 1.635E-48 5.882E-48 8.175E-48 20 71
6 IPR003054 Keratin II InterPro 3.758E-34 1.253E-33 4.507E-33 7.516E-33 13 26
7 IPR032444 Keratin 2 head InterPro 3.509E-28 8.772E-28 3.156E-27 7.018E-27 11 24
8 PF16208 Keratin 2 head Pfam 3.509E-28 8.772E-28 3.156E-27 7.018E-27 11 24
9 IPR002957 Keratin I InterPro 1.571E-27 3.491E-27 1.256E-26 3.142E-26 12 44
10 IPR009053 Prefoldin InterPro 6.228E-15 1.246E-14 4.481E-14 1.246E-13 8 72
11 IPR013805 GrpE coiled coil InterPro 7.845E-5 1.426E-4 5.131E-4 1.569E-3 2 12
12 IPR027695 Keratin-18 InterPro 1.121E-3 1.601E-3 5.761E-3 2.242E-2 1 1
13 IPR032449 Keratin 2 1 tail InterPro 1.121E-3 1.601E-3 5.761E-3 2.242E-2 1 1
14 PF16210 Keratin 2 tail Pfam 1.121E-3 1.601E-3 5.761E-3 2.242E-2 1 1
15 IPR010978 tRNA-bd arm InterPro 2.657E-2 3.458E-2
1.244E-1
5.315E-1
 1 24
16 IPR011072 HR1 rho-bd InterPro 2.767E-2 3.458E-2
1.244E-1
5.533E-1
 1 25
17 1.20.1270.60 - Gene3D 3.311E-2 3.679E-2
1.324E-1
6.622E-1
 1 30
18 IPR027267 AH/BAR-dom InterPro 3.311E-2 3.679E-2
1.324E-1
6.622E-1
 1 30
19 IPR010989 t-SNARE InterPro 4.713E-2 4.961E-2
1.785E-1
9.427E-1
 1 43
Show 14 more annotations

7: Pathway [Display Chart] 21 input genes in category / 8 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1457790 Keratinization BioSystems: REACTOME 3.214E-38 2.571E-37 6.987E-37 2.571E-37 21 214
2 138014 Glucocorticoid receptor regulatory network BioSystems: Pathway Interaction Database 3.362E-4 1.345E-3 3.655E-3 2.690E-3 3 82
3 138012 Signaling mediated by p38-alpha and p38-beta BioSystems: Pathway Interaction Database 1.559E-3 4.158E-3 1.130E-2 1.247E-2 2 35

8: Pubmed [Display Chart] 21 input genes in category / 2405 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16831889 New consensus nomenclature for mammalian keratins. Pubmed 8.517E-61 2.048E-57 1.713E-56 2.048E-57 21 63
2 19380743 Charting the molecular network of the drug target Bcr-Abl. Pubmed 1.082E-36 1.301E-33 1.088E-32 2.602E-33 18 266
3 29181608 Immunolocalization patterns of cytokeratins during salivary acinar cell development in mice. Pubmed 8.156E-26 6.538E-23 5.468E-22 1.961E-22 8 10
4 29563501 Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes. Pubmed 1.020E-24 6.134E-22 5.130E-21 2.454E-21 11 84
5 12399393 Hague (Hag). A new mouse hair mutation with an unstable semidominant allele. Pubmed 2.330E-24 1.121E-21 9.374E-21 5.605E-21 8 13
6 9932492 Lessons from keratin transgenic and knockout mice. Pubmed 8.812E-20 3.532E-17 2.954E-16 2.119E-16 6 7
7 16180309 Type II keratins precede type I keratins during early embryonic development. Pubmed 3.524E-19 1.059E-16 8.858E-16 8.474E-16 6 8
8 15731013 Identification of trichoplein, a novel keratin filament-binding protein. Pubmed 3.524E-19 1.059E-16 8.858E-16 8.474E-16 6 8
9 19199708 Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Pubmed 6.403E-19 1.711E-16 1.431E-15 1.540E-15 12 416
10 25324306 hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling. Pubmed 9.360E-18 2.251E-15 1.882E-14 2.251E-14 11 346
11 27545878 SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Pubmed 1.168E-17 2.555E-15 2.136E-14 2.810E-14 11 353
12 20818615 Immunohistochemical localization of cytokeratins in the junctional region of ectoderm and endoderm. Pubmed 6.307E-16 1.167E-13 9.758E-13 1.517E-12 5 7
13 24449888 Induced multipotency in adult keratinocytes through down-regulation of Î?Np63 or DGCR8. Pubmed 6.307E-16 1.167E-13 9.758E-13 1.517E-12 5 7
14 19515043 Comparative analysis of the expression of cytokeratins (1, 10, 14, 16, 4), involucrin, filaggrin and e-cadherin in plane warts and epidermodysplasia verruciformis plane wart-type lesions. Pubmed 1.681E-15 2.888E-13 2.415E-12 4.044E-12 5 8
15 29459677 A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Pubmed 4.696E-15 7.529E-13 6.296E-12 1.129E-11 9 247
16 21127502 Î?Np63 is an ectodermal gatekeeper of epidermal morphogenesis. Pubmed 7.561E-15 1.136E-12 9.504E-12 1.818E-11 5 10
17 21630459 Proteomic characterization of the human sperm nucleus. Pubmed 1.094E-14 1.548E-12 1.294E-11 2.631E-11 10 437
18 19032382 Antigen expression of human eccrine sweat glands. Pubmed 1.386E-14 1.851E-12 1.548E-11 3.332E-11 5 11
19 20572855 Developmental changes in cellular and extracellular structural macromolecules in the secondary palate and in the nasal cavity of the mouse. Pubmed 3.857E-14 4.638E-12 3.879E-11 9.277E-11 5 13
20 10087197 The genomic organization of type I keratin genes in mice. Pubmed 3.857E-14 4.638E-12 3.879E-11 9.277E-11 5 13
21 7518402 Expression of keratins in mouse vaginal epithelium. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
22 20398190 Significant high expression of cytokeratins 7, 8, 18, 19 in pulmonary large cell neuroendocrine carcinomas, compared to small cell lung carcinomas. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
23 15797458 Keratins of the human hair follicle. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
24 29884220 Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
25 19937336 Cytokeratin expression during mouse embryonic and early postnatal mammary gland development. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
26 2458356 Use of monospecific antisera and cRNA probes to localize the major changes in keratin expression during normal and abnormal epidermal differentiation. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
27 19776502 Expression of cytokeratins 10, 13, 14 and 19 in oral lichen planus. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
28 11062258 Cytokeratins 8 and 19 in the mouse placental development. Pubmed 6.752E-14 5.799E-12 4.850E-11 1.624E-10 4 4
29 18824566 AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis. Pubmed 1.852E-13 1.536E-11 1.284E-10 4.454E-10 5 17
30 22135020 Development, structure, and keratin expression in C57BL/6J mouse eccrine glands. Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
31 1713141 Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12. Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
32 27060708 Usefulness of immunocytochemistry using a Breast Marker antibody cocktail targeting P63/cytokeratin7/18/cytokeratin5/14 for fine needle aspiration of the breast: a retrospective cohort study of 139 cases. Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
33 9786956 Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development. Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
34 15944823 Eyelid fusion and epithelial differentiation at the ocular surface during mouse embryonic development. Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
35 20301457 Pachyonychia Congenita Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
36 11013209 Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality. Pubmed 3.375E-13 2.254E-11 1.885E-10 8.116E-10 4 5
37 15671067 Characterization of human epiplakin: RNAi-mediated epiplakin depletion leads to the disruption of keratin and vimentin IF networks. Pubmed 1.012E-12 6.241E-11 5.219E-10 2.434E-9 4 6
38 21983963 Distinct stem cells contribute to mammary gland development and maintenance. Pubmed 1.012E-12 6.241E-11 5.219E-10 2.434E-9 4 6
39 11321598 Cytokeratin, vimentin and E-cadherin immunodetection in the embryonic palate in two strains of mice with different susceptibility to glucocorticoid-induced clefting. Pubmed 1.012E-12 6.241E-11 5.219E-10 2.434E-9 4 6
40 27507811 Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis. Pubmed 1.269E-12 7.630E-11 6.381E-10 3.052E-9 5 24
41 27807348 mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Pubmed 1.586E-12 9.302E-11 7.779E-10 3.814E-9 5 25
42 15174051 An investigation into the human serum "interactome". Pubmed 2.398E-12 1.347E-10 1.126E-9 5.766E-9 7 162
43 28049658 Stage- and subunit-specific functions of polycomb repressive complex 2 in bladder urothelial formation and regeneration. Pubmed 2.408E-12 1.347E-10 1.126E-9 5.791E-9 5 27
44 10571739 Spatiotemporal expression pattern of keratins in skin of AP-2alpha-deficient mice. Pubmed 4.719E-12 2.522E-10 2.109E-9 1.135E-8 4 8
45 17330888 Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression. Pubmed 4.719E-12 2.522E-10 2.109E-9 1.135E-8 4 8
46 29450535 A Spatiotemporal Requirement for Prickle 1-Mediated PCP Signaling in Eyelid Morphogenesis and Homeostasis. Pubmed 8.492E-12 4.440E-10 3.713E-9 2.042E-8 4 9
47 23580065 Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy. Pubmed 1.133E-11 5.795E-10 4.846E-9 2.724E-8 6 96
48 21703447 Residual embryonic cells as precursors of a Barrett's-like metaplasia. Pubmed 1.415E-11 6.805E-10 5.691E-9 3.403E-8 4 10
49 25601450 Ontogeny of the mouse vocal fold epithelium. Pubmed 1.415E-11 6.805E-10 5.691E-9 3.403E-8 4 10
50 10852826 Interaction of plakophilins with desmoplakin and intermediate filament proteins: an in vitro analysis. Pubmed 1.415E-11 6.805E-10 5.691E-9 3.403E-8 4 10
Show 45 more annotations

9: Interaction [Display Chart] 21 input genes in category / 385 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:EPS15 EPS15 interactions 4.239E-20 1.632E-17 1.066E-16 1.632E-17 12 157
2 int:KRT15 KRT15 interactions 1.018E-18 1.959E-16 1.279E-15 3.917E-16 11 134
3 int:ZUP1 ZUP1 interactions 1.403E-17 1.800E-15 1.176E-14 5.400E-15 11 169
4 int:CRK CRK interactions 7.670E-17 7.382E-15 4.822E-14 2.953E-14 12 290
5 int:SHC1 SHC1 interactions 3.608E-15 2.647E-13 1.729E-12 1.389E-12 11 278
6 int:UBASH3B UBASH3B interactions 4.125E-15 2.647E-13 1.729E-12 1.588E-12 9 115
7 int:KRT38 KRT38 interactions 7.706E-14 4.238E-12 2.768E-11 2.967E-11 7 48
8 int:CBL CBL interactions 1.821E-13 8.763E-12 5.724E-11 7.011E-11 10 271
9 int:INPPL1 INPPL1 interactions 4.374E-13 1.871E-11 1.222E-10 1.684E-10 8 114
10 int:IQCB1 IQCB1 interactions 8.997E-13 3.464E-11 2.262E-10 3.464E-10 10 318
11 int:PIK3R2 PIK3R2 interactions 1.538E-12 5.382E-11 3.516E-10 5.921E-10 8 133
12 int:NPHP4 NPHP4 interactions 2.226E-12 7.141E-11 4.664E-10 8.569E-10 9 229
13 int:KRT5 KRT5 interactions 5.952E-12 1.763E-10 1.151E-9 2.292E-9 7 87
14 int:RNF31 RNF31 interactions 2.915E-11 8.016E-10 5.236E-9 1.122E-8 9 305
15 int:FAM92A FAM92A interactions 3.402E-11 8.733E-10 5.704E-9 1.310E-8 7 111
16 int:TCHP TCHP interactions 6.777E-11 1.631E-9 1.065E-8 2.609E-8 6 61
17 int:AP2M1 AP2M1 interactions 1.501E-10 3.399E-9 2.220E-8 5.779E-8 8 235
18 int:KRT13 KRT13 interactions 2.240E-10 4.791E-9 3.129E-8 8.623E-8 6 74
19 int:TNF TNF interactions 6.566E-10 1.331E-8 8.691E-8 2.528E-7 8 283
20 int:RPS6KB2 RPS6KB2 interactions 2.150E-9 4.140E-8 2.704E-7 8.279E-7 7 200
21 int:ALB ALB interactions 3.226E-9 5.915E-8 3.863E-7 1.242E-6 7 212
22 int:MINDY4 MINDY4 interactions 1.505E-8 2.633E-7 1.720E-6 5.793E-6 5 69
23 int:KRT2 KRT2 interactions 2.149E-8 3.597E-7 2.349E-6 8.273E-6 5 74
24 int:CUL2 CUL2 interactions 3.216E-8 5.158E-7 3.369E-6 1.238E-5 8 465
25 int:KRT31 KRT31 interactions 1.114E-7 1.716E-6 1.121E-5 4.290E-5 6 207
26 int:EVPL EVPL interactions 1.301E-7 1.926E-6 1.258E-5 5.007E-5 4 40
27 int:MKS1 MKS1 interactions 1.739E-7 2.479E-6 1.620E-5 6.695E-5 5 112
28 int:KRT17 KRT17 interactions 3.252E-7 4.472E-6 2.921E-5 1.252E-4 4 50
29 int:TTC23 TTC23 interactions 3.522E-7 4.676E-6 3.054E-5 1.356E-4 5 129
30 int:NEDD8 NEDD8 interactions 5.447E-7 6.991E-6 4.566E-5 2.097E-4 6 271
31 int:CUL5 CUL5 interactions 5.674E-7 7.047E-6 4.603E-5 2.185E-4 7 451
32 int:EIF4A3 EIF4A3 interactions 7.466E-7 8.982E-6 5.867E-5 2.874E-4 6 286
33 int:AHI1 AHI1 interactions 8.328E-7 9.716E-6 6.346E-5 3.206E-4 4 63
34 int:CUL4B CUL4B interactions 9.373E-7 1.061E-5 6.933E-5 3.609E-4 7 486
35 int:KRT10 KRT10 interactions 1.350E-6 1.485E-5 9.700E-5 5.198E-4 4 71
36 int:KRT40 KRT40 interactions 1.517E-6 1.622E-5 1.060E-4 5.840E-4 6 323
37 int:TEDC2 TEDC2 interactions 2.097E-6 2.182E-5 1.426E-4 8.075E-4 5 185
38 int:KRT3 KRT3 interactions 2.184E-6 2.212E-5 1.445E-4 8.407E-4 3 22
39 int:KRT8 KRT8 interactions 2.410E-6 2.379E-5 1.554E-4 9.278E-4 4 82
40 int:MAGOH MAGOH interactions 2.716E-6 2.614E-5 1.708E-4 1.046E-3 5 195
41 int:TRAF6 TRAF6 interactions 3.031E-6 2.846E-5 1.859E-4 1.167E-3 6 364
42 int:PAN2 PAN2 interactions 3.279E-6 3.006E-5 1.963E-4 1.262E-3 6 369
43 int:KRT7 KRT7 interactions 4.132E-6 3.699E-5 2.416E-4 1.591E-3 3 27
44 int:INVS INVS interactions 4.528E-6 3.962E-5 2.588E-4 1.743E-3 4 96
45 int:PTPRN2 PTPRN2 interactions 5.153E-6 4.409E-5 2.880E-4 1.984E-3 3 29
46 int:UCHL5 UCHL5 interactions 5.468E-6 4.576E-5 2.989E-4 2.105E-3 5 225
47 int:APC APC interactions 6.086E-6 4.985E-5 3.256E-4 2.343E-3 5 230
48 int:KIFC3 KIFC3 interactions 1.099E-5 8.816E-5 5.759E-4 4.232E-3 4 120
49 int:DSP DSP interactions 1.212E-5 9.523E-5 6.220E-4 4.666E-3 4 123
50 int:USP32 USP32 interactions 2.113E-5 1.627E-4 1.063E-3 8.136E-3 3 46
Show 45 more annotations

10: Cytoband [Display Chart] 21 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12q13.13 12q13.13 3.645E-17 2.551E-16 6.616E-16 2.551E-16 8 70
2 12q13 12q13 3.151E-12 1.103E-11 2.860E-11 2.206E-11 6 71
3 17q21.2 17q21.2 1.258E-5 2.936E-5 7.613E-5 8.808E-5 3 75
4 17q12-q21.2 17q12-q21.2 1.211E-3 2.120E-3 5.497E-3 8.480E-3 1 2
5 17q12-q21 17q12-q21 1.922E-2 2.690E-2
6.975E-2
1.345E-1
 1 32
6 17q21 17q21 3.749E-2 4.374E-2
1.134E-1
2.625E-1
 1 63
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 55 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 21 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 609 Keratins, type II genenames.org 1.060E-33 2.121E-33 3.181E-33 2.121E-33 13 27
2 608 Keratins, type I genenames.org 2.100E-18 2.100E-18 3.150E-18 4.201E-18 8 28

13: Coexpression [Display Chart] 21 input genes in category / 1460 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19584277-Table2 Human Breast Marella09 30genes GeneSigDB 1.935E-16 2.825E-13 2.222E-12 2.825E-13 7 28
2 15280706-Table2 Human Mouth Whipple04 50genes GeneSigDB 1.675E-15 1.216E-12 9.564E-12 2.445E-12 7 37
3 M10480 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes down-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.499E-15 1.216E-12 9.564E-12 3.649E-12 7 39
4 M863 Myb-regulated genes in MCF7 (breast cancer) and lung epithelial cell lines overexpressing MYBL2, MYBL1 or MYB [GeneID=4605;4603;4602]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.445E-14 2.352E-11 1.850E-10 9.410E-11 10 318
5 M4577 Top genes down-regulated in mesenchyme stem cells (MSC) grown in a tumor conditioned medium, which leads to carcinoma-associated fibroblast phenotype. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.549E-11 4.523E-9 3.557E-8 2.262E-8 5 24
6 M2533 Genes representing epithelial differentiation module in sputum during asthma exacerbations. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.950E-11 7.178E-9 5.645E-8 4.307E-8 6 69
7 M10702 Genes down-regulated in metastases from malignant melanoma compared to the primary tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.850E-11 8.031E-9 6.315E-8 5.621E-8 8 258
8 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.153E-10 2.105E-8 1.655E-7 1.684E-7 9 464
9 M13308 Genes up-regulated in primary keratinocytes at 1 h after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.184E-9 1.921E-7 1.511E-6 1.729E-6 4 17
10 16353136-Table2 Human Uterine Wong05 18genes GeneSigDB 1.522E-9 2.175E-7 1.711E-6 2.222E-6 4 18
11 M5505 Genes down-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.788E-9 2.175E-7 1.711E-6 2.611E-6 5 59
12 17409405-Table1b Human Breast Huper07 66genes LuminalCells GeneSigDB 1.788E-9 2.175E-7 1.711E-6 2.611E-6 5 59
13 19204204-SupplementaryTable4 Human Breast Parker09 161genes IntrinsicGenes RTPCR GeneSigDB 2.219E-9 2.492E-7 1.960E-6 3.240E-6 6 140
14 15833844-Table1S Human Esophagus Kimchi05 213genes GeneSigDB 7.650E-9 7.626E-7 5.997E-6 1.117E-5 6 172
15 M2700 Genes down-regulated in bone relapse of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.835E-9 7.626E-7 5.997E-6 1.144E-5 7 314
16 M8526 Protein profiles associated with survival in lung adenocarcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.681E-9 7.921E-7 6.229E-6 1.267E-5 4 27
17 M14553 Genes up-regulated in LD419 cells (fibroblast) after treatment with decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.773E-8 1.523E-6 1.198E-5 2.589E-5 4 32
18 11861364-Table1a Human Bladder Liang02 33genes GeneSigDB 2.017E-8 1.636E-6 1.286E-5 2.945E-5 4 33
19 20421987-TableS4 Human Lung Hou10 518genes GeneSigDB 2.909E-8 2.236E-6 1.758E-5 4.248E-5 7 380
20 M19218 Genes down-regulated in HET1A cells (esophagus epithelium) engineered to stably express CDX2 [GeneID=1045]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.598E-8 2.627E-6 2.065E-5 5.253E-5 3 8
21 15940270-Figure2D Human Ovarian Ouellet05 116genes GeneSigDB 4.054E-8 2.818E-6 2.216E-5 5.918E-5 5 109
22 M912 Genes up-regulated in short-term cultured glioblastomas after azacitidine [PubChem=9444] treatment. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.486E-8 2.977E-6 2.341E-5 6.550E-5 4 40
23 M8779 Proteins showing significant overexpression in lung cancer cell lines relative to normal bronchial epithelial cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.968E-8 3.154E-6 2.480E-5 7.253E-5 4 41
24 16024625-SuppTable2a Human Colon Craene05 185genes GeneSigDB 8.391E-8 5.105E-6 4.014E-5 1.225E-4 5 126
25 15637295-Table3 Human Breast Xu05 74genes upE2 GeneSigDB 1.124E-7 6.563E-6 5.161E-5 1.641E-4 4 50
26 20713713-TableS1a Human Breast Taube10 160genes EMTsignature down GeneSigDB 1.371E-7 7.500E-6 5.898E-5 2.002E-4 5 139
27 16115903-TableS1 Human Breast Rouzier05 298genes 4classes GeneSigDB 1.387E-7 7.500E-6 5.898E-5 2.025E-4 6 280
28 20421987-TableS5 Human Lung Hou10 75genes GeneSigDB 1.786E-7 9.313E-6 7.323E-5 2.608E-4 4 56
29 16449976-Table1 Human Esophagus Wang06 67genes GeneSigDB 2.209E-7 1.112E-5 8.746E-5 3.225E-4 4 59
30 20521089-SuppTable1a Human Breast Blick10 69genes EMT up GeneSigDB 3.703E-7 1.802E-5 1.417E-4 5.407E-4 4 67
31 M2769 Genes down-regulated during early stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 3.958E-7 1.864E-5 1.466E-4 5.779E-4 5 172
32 M836 Genes up-regulated in pirmary cultures of epithelial ovarian cancer (EOC): invasive (TOV) vs low malignant potential (LMP) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.172E-7 1.903E-5 1.497E-4 6.091E-4 4 69
33 15940270-Table3 Human Ovarian Ouellet05 30genes GeneSigDB 6.186E-7 2.737E-5 2.152E-4 9.031E-4 3 19
34 18435859-Table1 Mouse Breast Piechocki08 140genes GeneSigDB 6.847E-7 2.940E-5 2.312E-4 9.997E-4 4 78
35 M17175 Genes down-regulated in primary keratinocytes at 24 h after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.273E-7 3.034E-5 2.386E-4 1.062E-3 3 20
36 19204204-SupplementaryTable2 Human Breast Parker09 412genes IntrinsicGenes Perou2000 GeneSigDB 7.936E-7 3.134E-5 2.465E-4 1.159E-3 6 377
37 M14134 Genes down-regulated in ductal carcinoma vs normal ductal breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.943E-7 3.134E-5 2.465E-4 1.160E-3 5 198
38 M16756 Genes down-regulated in primary keratinocytes at 6 h after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.481E-7 3.208E-5 2.523E-4 1.238E-3 3 21
39 M12527 Down-regulated genes that vary between HNSCC (head and neck squamous cell carcinoma) groups formed on the basis of their level of pathological differentiation: well vs poorly differentiated tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.570E-7 3.208E-5 2.523E-4 1.251E-3 6 382
40 16061661-Table1 Human Ovarian Macleod05 87genes GeneSigDB 1.063E-6 3.879E-5 3.051E-4 1.552E-3 4 87
41 15374954-Table2 Human Breast Orsetti04 32genes GeneSigDB 1.128E-6 4.017E-5 3.159E-4 1.647E-3 3 23
42 M13186 Genes up-regulated during pubertal mammary gland development between weeks 3 and 4. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.165E-6 4.050E-5 3.185E-4 1.701E-3 5 214
43 14750170-Table1 Mouse Intestine DeGiovanni04 30genes GeneSigDB 2.080E-6 7.064E-5 5.555E-4 3.037E-3 3 28
44 15930339-Table3 Human Bladder Blaveri05 30genes SCCvsTCC GeneSigDB 2.319E-6 7.524E-5 5.917E-4 3.386E-3 3 29
45 11289099-Table2 Human HeadandNeck Shrieve01 37genes GeneSigDB 2.319E-6 7.524E-5 5.917E-4 3.386E-3 3 29
46 15885264-Table1 Mouse Lung not cancer Lee05 127genes GeneSigDB 2.435E-6 7.729E-5 6.078E-4 3.555E-3 4 107
47 M19768 Genes downregulated in MCF10A cells (breast cancer) co-cultured with cancer-associated fibroblasts (CAF). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.527E-6 7.851E-5 6.174E-4 3.690E-3 4 108
48 M19391 Genes down-regulated in prostate cancer samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.218E-6 9.789E-5 7.698E-4 4.699E-3 6 480
49 M19432 Genes up-regulated during pubertal mammary gland development between week 4 and 5. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.708E-6 1.043E-4 8.203E-4 5.414E-3 5 271
50 15532095-Table3 Human Prostate Kristiansen05 188genes GeneSigDB 3.721E-6 1.043E-4 8.203E-4 5.432E-3 4 119
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 21 input genes in category / 1295 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PCBC ctl BronchioEpithel 100 Progenitor-Cell-Biology-Consortium reference BronchioEpithel top-relative-expression-ranked 100 PCBC 2.824E-14 3.657E-11 2.832E-10 3.657E-11 8 100
2 Arv EB-LF 1000 K5 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.880E-13 9.892E-11 7.660E-10 2.434E-10 8 126
3 PCBC ctl BronchioEpithel 500 Progenitor-Cell-Biology-Consortium reference BronchioEpithel top-relative-expression-ranked 500 PCBC 2.292E-13 9.892E-11 7.660E-10 2.967E-10 11 499
4 BM Top 100 - trachea BM Top 100 - trachea Body Map 3.900E-13 1.262E-10 9.777E-10 5.050E-10 7 73
5 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - NOS/5/4 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - NOS/5/4 TCGA-Stomach 6.594E-13 1.708E-10 1.323E-9 8.539E-10 8 147
6 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K2 mendel RNAseq e18.5 Urothelium Krt5CreRFP 2500 K2 Gudmap RNAseq 2.150E-12 3.978E-10 3.080E-9 2.784E-9 10 427
7 Facebase ST1 Univ 500 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 FaceBase_ST1 2.150E-12 3.978E-10 3.080E-9 2.784E-9 10 427
8 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/6 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/6 TCGA-Esophagus 3.395E-12 5.495E-10 4.255E-9 4.396E-9 8 180
9 Arv EB-LF 2500 K3 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 9.784E-12 1.282E-9 9.930E-9 1.267E-8 9 332
10 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 1.005E-11 1.282E-9 9.930E-9 1.302E-8 8 206
11 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/4 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/4 TCGA-Prostate 1.089E-11 1.282E-9 9.930E-9 1.411E-8 7 116
12 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/1/3 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Adenocarcinoma/1/3 TCGA-Esophagus 1.471E-11 1.587E-9 1.229E-8 1.905E-8 7 121
13 Arv EB-LF 500 K4 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 k-means-cluster#4 PCBC 1.752E-11 1.746E-9 1.352E-8 2.269E-8 6 60
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Renal cell carcinoma/Ureter Normal RCC Renal cell carcinoma/Ureter Normal RCC T10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Renal cell carcinoma/Ureter Normal RCC Renal cell carcinoma/Ureter Normal RCC T10 Adult, Development, and Cancer types 3.201E-11 2.961E-9 2.293E-8 4.145E-8 5 26
15 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 500 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 5.388E-11 4.651E-9 3.602E-8 6.977E-8 9 402
16 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/3/3 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/3/3 TCGA-Pancreas 6.740E-11 5.381E-9 4.167E-8 8.729E-8 7 150
17 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/5/1 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/5/1 TCGA-Breast 7.064E-11 5.381E-9 4.167E-8 9.148E-8 7 151
18 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 200 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.562E-10 1.124E-8 8.701E-8 2.022E-7 7 169
19 gudmap developingLowerUrinaryTract e13.5 bladder neck-urethr epithel 100 DevelopingLowerUrinaryTract e13.5 bladder neck-urethr epithel emap-30875 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 1.866E-10 1.272E-8 9.848E-8 2.416E-7 6 88
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Nephrogenesis/Ureter Normal RCC Nephrogenesis/Ureter Normal RCC F10 Adult, Development, and Cancer types 2.628E-10 1.702E-8 1.318E-7 3.404E-7 7 182
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell 1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell 1 Adult, Development, and Cancer types 2.838E-10 1.750E-8 1.355E-7 3.675E-7 7 184
22 PCBC ctl SmallAirwayEpithel 100 Progenitor-Cell-Biology-Consortium reference SmallAirwayEpithel top-relative-expression-ranked 100 PCBC 4.075E-10 2.399E-8 1.858E-7 5.277E-7 6 100
23 gudmap developingLowerUrinaryTract P1 bladder 500 B DevelopingLowerUrinaryTract P1 bladder B emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.450E-9 8.165E-8 6.323E-7 1.878E-6 8 385
24 gudmap developingLowerUrinaryTract P1 bladder 500 J DevelopingLowerUrinaryTract P1 bladder J emap-30374 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.605E-9 8.661E-8 6.707E-7 2.079E-6 8 390
25 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 mendel RNAseq e12.5 Urothelium ShhCreRFP 2500 K1 Gudmap RNAseq 2.077E-9 1.076E-7 8.331E-7 2.690E-6 8 403
26 esophagus esophagus Human Protein Atlas 2.216E-9 1.104E-7 8.547E-7 2.870E-6 7 247
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal RCC U U/Ureter Normal RCC U10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U/Ureter Normal RCC U U/Ureter Normal RCC U10 Adult, Development, and Cancer types 3.035E-9 1.456E-7 1.127E-6 3.931E-6 4 20
28 gudmap developingLowerUrinaryTract P2 bladder urothelium (LCM) 200 DevelopingLowerUrinaryTract P2 bladder urothelium (LCM) emap-30380 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 5.139E-9 2.377E-7 1.840E-6 6.654E-6 6 152
29 Facebase ST1 e10.5 ColumEpith Mandib 100 e10.5 ColumEpith Mandib top-relative-expression-ranked 100 FaceBase_ST1 6.619E-9 2.867E-7 2.220E-6 8.572E-6 5 72
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium Adult, Development, and Cancer types 6.641E-9 2.867E-7 2.220E-6 8.600E-6 4 24
31 BM Top 100 - mammary gland BM Top 100 - mammary gland Body Map 7.612E-9 3.080E-7 2.385E-6 9.857E-6 5 74
32 Facebase ST1 e9.5 OlfacPlacod 100 e9.5 OlfacPlacod top-relative-expression-ranked 100 FaceBase_ST1 7.612E-9 3.080E-7 2.385E-6 9.857E-6 5 74
33 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k3 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 7.901E-9 3.100E-7 2.401E-6 1.023E-5 4 25
34 BM Top 100 - vagina BM Top 100 - vagina Body Map 8.719E-9 3.321E-7 2.572E-6 1.129E-5 5 76
35 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter U U Adult, Development, and Cancer types 9.040E-9 3.345E-7 2.590E-6 1.171E-5 6 167
36 gudmap developingLowerUrinaryTract e14.5 urethra 500 k1 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.062E-8 3.819E-7 2.958E-6 1.375E-5 5 79
37 ratio EB vs SC 2500 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 2500 k-means-cluster#5 PCBC 1.192E-8 4.108E-7 3.181E-6 1.543E-5 7 315
38 Facebase ST1 e10.5 ColumEpith Maxil 100 e10.5 ColumEpith Maxil top-relative-expression-ranked 100 FaceBase_ST1 1.206E-8 4.108E-7 3.181E-6 1.561E-5 5 81
39 Facebase ST1 e10.5 ColumEpith Mandib 250 e10.5 ColumEpith Mandib top-relative-expression-ranked 250 FaceBase_ST1 1.281E-8 4.131E-7 3.199E-6 1.658E-5 6 177
40 Facebase ST1 Univ 500 3 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 3 FaceBase_ST1 1.283E-8 4.131E-7 3.199E-6 1.661E-5 5 82
41 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R15 Adult, Development, and Cancer types 1.370E-8 4.131E-7 3.199E-6 1.774E-5 6 179
42 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Mast cell Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Mast cell Adult, Development, and Cancer types 1.416E-8 4.131E-7 3.199E-6 1.834E-5 6 180
43 Facebase ST1 Univ 100 UniversalReference WholeMouseP1 top-relative-expression-ranked 100 FaceBase_ST1 1.450E-8 4.131E-7 3.199E-6 1.878E-5 5 84
44 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium/Ureter Normal RCC Ureter epithelium/Ureter Normal RCC N15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Ureter epithelium/Ureter Normal RCC Ureter epithelium/Ureter Normal RCC N15 Adult, Development, and Cancer types 1.464E-8 4.131E-7 3.199E-6 1.895E-5 6 181
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Papillary renal cell carcinoma Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter Papillary renal cell carcinoma Adult, Development, and Cancer types 1.464E-8 4.131E-7 3.199E-6 1.895E-5 6 181
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter EN-U Adult, Development, and Cancer types 1.513E-8 4.131E-7 3.199E-6 1.959E-5 6 182
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter R U/Ureter Normal RCC R U/Ureter Normal RCC R10 Adult, Development, and Cancer types 1.563E-8 4.131E-7 3.199E-6 2.024E-5 6 183
48 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK10 Adult, Development, and Cancer types 1.563E-8 4.131E-7 3.199E-6 2.024E-5 6 183
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U Adult, Development, and Cancer types 1.563E-8 4.131E-7 3.199E-6 2.024E-5 6 183
50 BM Top 100 - esophagus BM Top 100 - esophagus Body Map 1.634E-8 4.231E-7 3.276E-6 2.116E-5 5 86
Show 45 more annotations

15: Computational [Display Chart] 19 input genes in category / 120 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13118 MODULE 298 Keratin. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.329E-35 5.598E-33 3.005E-32 1.120E-32 14 26
2 M19014 MODULE 68 Genes in the cancer module 68. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.329E-35 5.598E-33 3.005E-32 1.120E-32 14 26
3 M17509 MODULE 438 Intermediate filaments and MT. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.521E-15 6.083E-14 3.266E-13 1.825E-13 9 68
4 M18849 MODULE 153 Genes in the cancer module 153. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.297E-13 3.891E-12 2.089E-11 1.556E-11 7 34
5 M9185 MODULE 357 Intermediate filaments and keratins. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.297E-11 1.751E-9 9.402E-9 8.756E-9 7 80
6 M16667 MODULE 342 Genes in the cancer module 342. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.315E-9 4.631E-8 2.486E-7 2.779E-7 8 214
7 M4992 MODULE 297 Genes in the cancer module 297. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.295E-9 9.077E-8 4.874E-7 6.354E-7 6 80
8 M1846 MODULE 220 Developmental processes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.484E-6 2.226E-5 1.195E-4 1.781E-4 7 333
9 M7360 MODULE 33 Immune / stress response genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.776E-6 5.035E-5 2.703E-4 4.532E-4 7 383
10 M18170 MODULE 154 Intermediate filaments. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.024E-5 1.229E-4 6.596E-4 1.229E-3 4 75
11 M2266 GNF2 SPRR1B Neighborhood of SPRR1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.289E-5 1.406E-4 7.547E-4 1.546E-3 3 25
12 M9365 GNF2 SERPINB5 Neighborhood of SERPINB5 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.829E-5 1.829E-4 9.818E-4 2.194E-3 3 28
13 M1901 MODULE 533 Genes in the cancer module 533. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.762E-5 7.165E-4 3.847E-3 9.314E-3 3 45
14 M15336 MODULE 6 Trachea genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.372E-5 7.176E-4 3.853E-3 1.005E-2 6 416
15 M931 GCM PTPRU Neighborhood of PTPRU MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.342E-4 1.074E-3 5.765E-3 1.611E-2 3 54
16 M10909 MODULE 418 Genes in the cancer module 418. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.838E-4 1.379E-3 7.403E-3 2.206E-2 3 60
17 M3463 MODULE 44 Thymus genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.840E-4 2.004E-3 1.076E-2 3.407E-2 5 327
18 M19525 MODULE 139 Genes in the cancer module 139. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.153E-4 2.769E-3 1.486E-2 4.984E-2 3 79
19 M10190 MODULE 52 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.027E-3 6.487E-3 3.483E-2
1.233E-1
 5 433
20 M17677 GNF2 CDH3 Neighborhood of CDH3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.159E-3 6.951E-3 3.732E-2
1.390E-1
 2 27
21 M16071 MODULE 38 Placenta genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.401E-3 7.660E-3 4.112E-2
1.681E-1
 5 464
22 M8449 MODULE 180 Genes in the cancer module 180. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.404E-3 7.660E-3 4.112E-2
1.685E-1
 3 120
23 M16117 MODULE 455 Genes in the cancer module 455. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.413E-3 1.259E-2
6.759E-2
2.896E-1
 2 39
24 M8074 MODULE 111 Genes in the cancer module 111. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.813E-3 1.407E-2
7.552E-2
3.376E-1
 3 153
25 M9866 MORF THRA Neighborhood of THRA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.582E-3 2.199E-2
1.181E-1
5.498E-1
 2 54
26 M9347 MODULE 176 Signaling. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.774E-3 4.050E-2
2.174E-1
1.000E0
 3 230
27 M17328 MORF MYC Neighborhood of MYC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.591E-3 4.263E-2
2.289E-1
1.000E0
 2 79
Show 22 more annotations

16: MicroRNA [Display Chart] 21 input genes in category / 173 annotations before applied cutoff / 72241 genes in category

No results to display

17: Drug [Display Chart] 21 input genes in category / 2667 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000072425 teleocidin B Stitch 1.731E-45 4.617E-42 3.909E-41 4.617E-42 20 123
2 CID000010461 sulfur mustard Stitch 5.745E-45 6.028E-42 5.103E-41 1.532E-41 20 130
3 CID000107712 homocysteine thiolactone Stitch 6.780E-45 6.028E-42 5.103E-41 1.808E-41 20 131
4 CID000004545 al-Badry Stitch 9.496E-43 6.331E-40 5.360E-39 2.532E-39 20 165
5 CID000448959 AC1L9MJT Stitch 2.341E-41 1.248E-38 1.057E-37 6.242E-38 20 192
6 CID000011820 1-2q Stitch 1.181E-37 5.252E-35 4.446E-34 3.151E-34 20 289
7 CID000093860 Velcade (bortezomib Stitch 2.387E-35 9.096E-33 7.701E-32 6.367E-32 20 374
8 CID000447960 CK 6 Stitch 6.141E-27 2.047E-24 1.733E-23 1.638E-23 12 58
9 CID005494414 olomoucine II Stitch 2.778E-25 8.234E-23 6.971E-22 7.410E-22 10 27
10 CID000447959 1pxm Stitch 1.406E-22 3.749E-20 3.174E-19 3.749E-19 11 79
11 ctd:C034814 ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid CTD 2.753E-19 6.675E-17 5.651E-16 7.343E-16 6 6
12 CID000128831 CK17 Stitch 5.552E-19 1.234E-16 1.045E-15 1.481E-15 9 57
13 ctd:C002202 4-oxoretinoic acid CTD 2.362E-18 4.846E-16 4.102E-15 6.299E-15 10 115
14 CID000003512 NSC34533 Stitch 1.127E-16 2.147E-14 1.818E-13 3.006E-13 8 54
15 CID006437063 4-oxoretinoic acid Stitch 2.253E-15 4.006E-13 3.392E-12 6.009E-12 8 77
16 ctd:C103303 alitretinoin CTD 4.512E-14 7.520E-12 6.367E-11 1.203E-10 10 303
17 CID000003829 AC1L1GT5 Stitch 1.906E-12 2.990E-10 2.532E-9 5.084E-9 7 95
18 CID000002202 dithranol Stitch 3.341E-12 4.951E-10 4.191E-9 8.911E-9 5 18
19 ctd:C025319 phenyl isocyanate CTD 7.909E-12 1.110E-9 9.398E-9 2.109E-8 4 6
20 ctd:C002741 N-nitrosomorpholine CTD 8.326E-12 1.110E-9 9.400E-9 2.221E-8 9 341
21 CID000447961 2C5P Stitch 1.515E-11 1.924E-9 1.629E-8 4.041E-8 7 127
22 CID005282177 AC1NQZM2 Stitch 4.602E-11 5.578E-9 4.723E-8 1.227E-7 5 29
23 CID000119342 CD367 Stitch 9.175E-11 1.064E-8 9.007E-8 2.447E-7 5 33
24 CID005487705 I5B1 Stitch 1.681E-10 1.724E-8 1.460E-7 4.484E-7 5 37
25 CID000011510 N-hydroxyurethane Stitch 1.681E-10 1.724E-8 1.460E-7 4.484E-7 5 37
26 CID000068111 chrysarobin Stitch 1.681E-10 1.724E-8 1.460E-7 4.484E-7 5 37
27 CID006437076 Ro 13-6298 Stitch 3.754E-10 3.708E-8 3.139E-7 1.001E-6 4 13
28 CID000447958 1pxl Stitch 7.303E-10 6.956E-8 5.889E-7 1.948E-6 5 49
29 CID000002791 clobestasol propionate Stitch 1.247E-9 1.108E-7 9.383E-7 3.325E-6 4 17
30 CID000469667 K-11 Stitch 1.247E-9 1.108E-7 9.383E-7 3.325E-6 4 17
31 CID000006001 DMBA Stitch 2.395E-9 2.060E-7 1.744E-6 6.387E-6 6 140
32 CID000032797 Olux Stitch 2.533E-9 2.111E-7 1.787E-6 6.756E-6 4 20
33 ctd:C541923 sandostatinLAR CTD 3.214E-9 2.597E-7 2.199E-6 8.570E-6 6 147
34 CID000191841 Lh 1 Stitch 3.820E-9 2.997E-7 2.537E-6 1.019E-5 4 22
35 CID000002522 Divonex Stitch 4.254E-9 3.242E-7 2.744E-6 1.135E-5 5 69
36 ctd:C041819 4-oxoretinol CTD 4.622E-9 3.424E-7 2.899E-6 1.233E-5 4 23
37 CID000041317 9-cis-acitretin Stitch 4.923E-9 3.548E-7 3.004E-6 1.313E-5 5 71
38 CID000018752 plakin Stitch 1.025E-8 7.104E-7 6.014E-6 2.734E-5 5 82
39 CID011650719 [(2R,3R,4R,5S,6R)-2-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-5-hydroxy-6-(hydroxymethyl)-3-[(2-tritioacetyl)amino]oxan-4-yl] (3R)-3-hydroxydecanoate Stitch 1.065E-8 7.104E-7 6.014E-6 2.842E-5 4 28
40 CID000016533 betamethasone valerate Stitch 1.065E-8 7.104E-7 6.014E-6 2.842E-5 4 28
41 CID000010603 hematoxilina Stitch 1.196E-8 7.782E-7 6.588E-6 3.191E-5 6 183
42 CID000517862 ClOClO Stitch 1.337E-8 8.105E-7 6.862E-6 3.566E-5 3 6
43 CID000281830 NSC134723 Stitch 1.337E-8 8.105E-7 6.862E-6 3.566E-5 3 6
44 CID010291510 SC-791 Stitch 1.337E-8 8.105E-7 6.862E-6 3.566E-5 3 6
45 CID000469669 K-13 Stitch 1.634E-8 9.687E-7 8.201E-6 4.359E-5 4 31
46 CID006437379 mucidin Stitch 1.867E-8 1.082E-6 9.163E-6 4.979E-5 4 32
47 CID006432276 potassiopotassium Stitch 2.048E-8 1.162E-6 9.837E-6 5.461E-5 5 94
48 CID000006035 bromodeoxyuridine Stitch 2.954E-8 1.641E-6 1.389E-5 7.877E-5 7 376
49 CID000002123 hexamethylmelamine Stitch 3.093E-8 1.683E-6 1.425E-5 8.248E-5 5 102
50 CID000620368 A805480 Stitch 6.997E-8 3.732E-6 3.160E-5 1.866E-4 4 44
Show 45 more annotations

18: Disease [Display Chart] 21 input genes in category / 525 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0221260 Dystrophia unguium DisGeNET Curated 2.924E-20 1.535E-17 1.050E-16 1.535E-17 10 55
2 C0022596 Palmoplantar Keratosis DisGeNET Curated 1.667E-16 4.376E-14 2.994E-13 8.752E-14 9 75
3 C0265334 Pachyonychia Congenita DisGeNET Curated 3.685E-15 6.449E-13 4.412E-12 1.935E-12 6 13
4 C1704317 Leukokeratosis DisGeNET Curated 8.278E-14 1.086E-11 7.433E-11 4.346E-11 6 20
5 C0853087 Nail abnormality DisGeNET Curated 1.591E-13 1.670E-11 1.143E-10 8.352E-11 6 22
6 C0079298 Epidermolysis Bullosa Simplex DisGeNET Curated 3.767E-13 2.607E-11 1.783E-10 1.978E-10 6 25
7 C2132198 Abnormal blistering of the skin DisGeNET Curated 4.469E-13 2.607E-11 1.783E-10 2.346E-10 7 56
8 C2220104 Blister of skin DisGeNET Curated 4.469E-13 2.607E-11 1.783E-10 2.346E-10 7 56
9 C0241054 Skin bulla DisGeNET Curated 4.469E-13 2.607E-11 1.783E-10 2.346E-10 7 56
10 C0027339 Nail Diseases DisGeNET Curated 6.287E-13 3.300E-11 2.258E-10 3.300E-10 6 27
11 C0263537 Onychogryposis DisGeNET Curated 4.345E-12 2.074E-10 1.419E-9 2.281E-9 5 14
12 C0546966 Monilethrix DisGeNET Curated 1.041E-11 4.554E-10 3.116E-9 5.465E-9 4 5
13 C0870082 Hyperkeratosis DisGeNET Curated 4.225E-11 1.706E-9 1.167E-8 2.218E-8 7 105
14 C1834405 Nail dysplasia DisGeNET Curated 6.738E-11 2.527E-9 1.729E-8 3.538E-8 6 56
15 C0023532 Leukoplakia, Oral DisGeNET Curated 2.053E-10 7.186E-9 4.916E-8 1.078E-7 6 67
16 C0334013 Phrynoderma DisGeNET Curated 6.836E-10 2.118E-8 1.449E-7 3.589E-7 4 11
17 C0020458 Hyperhidrosis disorder DisGeNET Curated 7.667E-10 2.118E-8 1.449E-7 4.025E-7 6 83
18 C0700590 Increased sweating DisGeNET Curated 7.667E-10 2.118E-8 1.449E-7 4.025E-7 6 83
19 C0038990 Sweating DisGeNET Curated 7.667E-10 2.118E-8 1.449E-7 4.025E-7 6 83
20 cv:C0546966 Beaded hair Clinical Variations 1.876E-9 4.689E-8 3.208E-7 9.847E-7 3 3
21 OMIN:158000 MONILETHRIX OMIM 1.876E-9 4.689E-8 3.208E-7 9.847E-7 3 3
22 C4024867 Perifollicular hyperkeratosis DisGeNET Curated 7.496E-9 1.711E-7 1.171E-6 3.935E-6 3 4
23 C0432316 Epidermolysis bullosa simplex with mottled pigmentation DisGeNET Curated 7.496E-9 1.711E-7 1.171E-6 3.935E-6 3 4
24 C1862862 Patchy alopecia DisGeNET Curated 1.872E-8 3.932E-7 2.690E-6 9.830E-6 3 5
25 C4020960 Abnormality of nail color DisGeNET Curated 1.872E-8 3.932E-7 2.690E-6 9.830E-6 3 5
26 C0020757 Ichthyoses DisGeNET Curated 2.331E-8 4.688E-7 3.208E-6 1.224E-5 5 69
27 C1970705 Fragile hair DisGeNET Curated 2.590E-8 4.688E-7 3.208E-6 1.360E-5 4 25
28 C4072837 Fractured hair DisGeNET Curated 2.590E-8 4.688E-7 3.208E-6 1.360E-5 4 25
29 C1851868 Reduced tensile strength of hair DisGeNET Curated 2.590E-8 4.688E-7 3.208E-6 1.360E-5 4 25
30 C0263490 Brittle hair DisGeNET Curated 3.587E-8 6.277E-7 4.295E-6 1.883E-5 4 27
31 C1833030 PALMOPLANTAR KERATODERMA, NONEPIDERMOLYTIC DisGeNET Curated 6.543E-8 1.108E-6 7.581E-6 3.435E-5 3 7
32 C0022584 Keratoderma, Palmoplantar, Diffuse DisGeNET Curated 2.238E-7 3.671E-6 2.512E-5 1.175E-4 3 10
33 C0037277 Skin Diseases, Genetic DisGeNET BeFree 2.489E-7 3.959E-6 2.709E-5 1.307E-4 4 43
34 C4011556 Eyebrow abnormalities DisGeNET Curated 4.095E-7 6.324E-6 4.326E-5 2.150E-4 3 12
35 C0037286 Skin Neoplasms DisGeNET Curated 4.466E-7 6.699E-6 4.583E-5 2.345E-4 6 240
36 C2675111 Abnormal eyelashes DisGeNET Curated 5.320E-7 7.758E-6 5.308E-5 2.793E-4 3 13
37 C0796195 Waisman syndrome DisGeNET Curated 6.765E-7 9.346E-6 6.394E-5 3.552E-4 3 14
38 C0079153 Hyperkeratosis, Epidermolytic DisGeNET Curated 6.765E-7 9.346E-6 6.394E-5 3.552E-4 3 14
39 C4021768 Abnormality of metabolism/homeostasis DisGeNET Curated 7.064E-7 9.509E-6 6.506E-5 3.708E-4 5 136
40 C0677944 Sentinel node (disorder) DisGeNET BeFree 8.448E-7 1.109E-5 7.586E-5 4.435E-4 4 58
41 C0011334 Dental caries DisGeNET Curated 1.004E-6 1.286E-5 8.796E-5 5.271E-4 5 146
42 C1843463 Ichthyosis, Cyclic, with Epidermolytic Hyperkeratosis DisGeNET Curated 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
43 C0432315 Epidermolysis bullosa simplex herpetiformis DisGeNET BeFree 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
44 OMIN:607602 ICHTHYOSIS, CYCLIC, WITH EPIDERMOLYTIC HYPERKERATOSIS OMIM 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
45 cv:C0079299 Epidermolysis bullosa simplex, Koebner type Clinical Variations 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
46 C0263580 Ichthyosis hystrix DisGeNET BeFree 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
47 C0079295 Epidermolysis Bullosa Herpetiformis Dowling-Meara DisGeNET Curated 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
48 OMIN:131760 EPIDERMOLYSIS BULLOSA SIMPLEX, DOWLING-MEARA TYPE OMIM 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
49 cv:C1843463 Ichthyosis, cyclic, with epidermolytic hyperkeratosis Clinical Variations 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
50 cv:C0079153 Bullous ichthyosiform erythroderma Clinical Variations 1.599E-6 1.354E-5 9.266E-5 8.397E-4 2 2
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