Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc130_26, positive side

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1: GO: Molecular Function [Display Chart] 26 input genes in category / 114 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005544 calcium-dependent phospholipid binding 5.848E-15 6.666E-13 3.545E-12 6.666E-13 8 56
2 GO:0030276 clathrin binding 2.344E-14 1.336E-12 7.106E-12 2.672E-12 8 66
3 GO:0005543 phospholipid binding 4.924E-11 1.531E-9 8.142E-9 5.613E-9 10 385
4 GO:0019905 syntaxin binding 5.372E-11 1.531E-9 8.142E-9 6.124E-9 7 98
5 GO:0000149 SNARE binding 4.935E-10 1.125E-8 5.984E-8 5.626E-8 7 134
6 GO:1901981 phosphatidylinositol phosphate binding 8.226E-7 1.563E-5 8.311E-5 9.377E-5 5 128
7 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1.279E-6 2.083E-5 1.108E-4 1.458E-4 4 59
8 GO:1902936 phosphatidylinositol bisphosphate binding 4.809E-6 6.853E-5 3.644E-4 5.483E-4 4 82
9 GO:0035091 phosphatidylinositol binding 1.095E-5 1.359E-4 7.225E-4 1.248E-3 5 217
10 GO:0004725 protein tyrosine phosphatase activity 1.192E-5 1.359E-4 7.225E-4 1.359E-3 4 103
11 GO:0017137 Rab GTPase binding 2.896E-5 3.001E-4 1.596E-3 3.301E-3 4 129
12 GO:0004721 phosphoprotein phosphatase activity 1.360E-4 1.292E-3 6.870E-3 1.550E-2 4 192
13 GO:0042578 phosphoric ester hydrolase activity 2.769E-4 2.428E-3 1.291E-2 3.157E-2 5 429
14 GO:0017016 Ras GTPase binding 5.794E-4 4.462E-3 2.373E-2
6.605E-2
 4 281
15 GO:0016791 phosphatase activity 5.871E-4 4.462E-3 2.373E-2
6.693E-2
 4 282
16 GO:0031267 small GTPase binding 7.496E-4 5.341E-3 2.840E-2
8.545E-2
 4 301
17 GO:0051020 GTPase binding 1.020E-3 6.843E-3 3.639E-2
1.163E-1
 4 327
18 GO:0001565 phorbol ester receptor activity 2.785E-3 1.671E-2
8.885E-2
3.175E-1
 1 2
19 GO:0001566 non-kinase phorbol ester receptor activity 2.785E-3 1.671E-2
8.885E-2
3.175E-1
 1 2
20 GO:0035662 Toll-like receptor 4 binding 5.562E-3 3.019E-2
1.606E-1
6.341E-1
 1 4
21 GO:0043533 inositol 1,3,4,5 tetrakisphosphate binding 5.562E-3 3.019E-2
1.606E-1
6.341E-1
 1 4
Show 16 more annotations

2: GO: Biological Process [Display Chart] 26 input genes in category / 741 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016079 synaptic vesicle exocytosis 1.299E-19 9.625E-17 6.917E-16 9.625E-17 11 90
2 GO:0099643 signal release from synapse 1.165E-18 2.877E-16 2.067E-15 8.631E-16 12 163
3 GO:0007269 neurotransmitter secretion 1.165E-18 2.877E-16 2.067E-15 8.631E-16 12 163
4 GO:0099531 presynaptic process involved in chemical synaptic transmission 2.422E-18 4.486E-16 3.224E-15 1.795E-15 12 173
5 GO:0099504 synaptic vesicle cycle 3.896E-18 5.773E-16 4.149E-15 2.887E-15 11 121
6 GO:0097480 establishment of synaptic vesicle localization 1.141E-17 1.057E-15 7.594E-15 8.455E-15 11 133
7 GO:0048489 synaptic vesicle transport 1.141E-17 1.057E-15 7.594E-15 8.455E-15 11 133
8 GO:0017156 calcium ion regulated exocytosis 1.141E-17 1.057E-15 7.594E-15 8.455E-15 11 133
9 GO:0097479 synaptic vesicle localization 2.211E-17 1.820E-15 1.308E-14 1.638E-14 11 141
10 GO:0006836 neurotransmitter transport 2.907E-17 2.154E-15 1.548E-14 2.154E-14 12 212
11 GO:0001505 regulation of neurotransmitter levels 3.260E-17 2.196E-15 1.578E-14 2.415E-14 12 214
12 GO:0045055 regulated exocytosis 6.188E-17 3.821E-15 2.746E-14 4.586E-14 13 315
13 GO:0023061 signal release 5.746E-16 3.275E-14 2.354E-13 4.258E-13 14 498
14 GO:0017157 regulation of exocytosis 1.469E-15 7.773E-14 5.586E-13 1.088E-12 11 205
15 GO:0006887 exocytosis 4.450E-15 2.138E-13 1.536E-12 3.297E-12 13 438
16 GO:0017158 regulation of calcium ion-dependent exocytosis 4.615E-15 2.138E-13 1.536E-12 3.420E-12 9 95
17 GO:0051650 establishment of vesicle localization 1.446E-14 6.303E-13 4.530E-12 1.072E-11 11 252
18 GO:0051648 vesicle localization 2.735E-14 1.126E-12 8.092E-12 2.027E-11 11 267
19 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter 5.244E-14 2.045E-12 1.470E-11 3.886E-11 7 38
20 GO:1903305 regulation of regulated secretory pathway 2.144E-13 7.945E-12 5.709E-11 1.589E-10 9 144
21 GO:0051656 establishment of organelle localization 6.048E-12 2.134E-10 1.533E-9 4.481E-9 11 438
22 GO:0045956 positive regulation of calcium ion-dependent exocytosis 3.391E-10 1.142E-8 8.207E-8 2.513E-7 5 28
23 GO:0006906 vesicle fusion 1.213E-9 3.908E-8 2.808E-7 8.988E-7 7 152
24 GO:0090174 organelle membrane fusion 1.329E-9 4.104E-8 2.949E-7 9.850E-7 7 154
25 GO:0045921 positive regulation of exocytosis 2.798E-9 8.292E-8 5.959E-7 2.073E-6 6 93
26 GO:0048284 organelle fusion 8.793E-9 2.506E-7 1.801E-6 6.516E-6 7 202
27 GO:1903307 positive regulation of regulated secretory pathway 1.284E-8 3.523E-7 2.532E-6 9.512E-6 5 56
28 GO:0016050 vesicle organization 1.786E-8 4.726E-7 3.396E-6 1.323E-5 8 353
29 GO:0061025 membrane fusion 1.852E-8 4.733E-7 3.401E-6 1.372E-5 7 225
30 GO:0016082 synaptic vesicle priming 1.622E-6 4.005E-5 2.878E-4 1.202E-3 3 17
31 GO:1990504 dense core granule exocytosis 1.874E-6 4.480E-5 3.219E-4 1.389E-3 2 2
32 GO:0036465 synaptic vesicle recycling 1.058E-5 2.399E-4 1.724E-3 7.840E-3 3 31
33 GO:0035335 peptidyl-tyrosine dephosphorylation 1.069E-5 2.399E-4 1.724E-3 7.918E-3 4 100
34 GO:0030073 insulin secretion 1.495E-5 3.259E-4 2.342E-3 1.108E-2 5 231
35 GO:1903532 positive regulation of secretion by cell 1.914E-5 4.053E-4 2.912E-3 1.418E-2 6 417
36 GO:0051047 positive regulation of secretion 2.939E-5 6.050E-4 4.347E-3 2.178E-2 6 450
37 GO:0030072 peptide hormone secretion 3.894E-5 7.799E-4 5.604E-3 2.886E-2 5 282
38 GO:0002790 peptide secretion 4.450E-5 8.677E-4 6.235E-3 3.297E-2 5 290
39 GO:0072583 clathrin-dependent endocytosis 5.102E-5 9.693E-4 6.966E-3 3.780E-2 3 52
40 GO:0046879 hormone secretion 1.188E-4 2.148E-3 1.543E-2
8.806E-2
 5 357
41 GO:0015833 peptide transport 1.188E-4 2.148E-3 1.543E-2
8.806E-2
 5 357
42 GO:0009914 hormone transport 1.405E-4 2.479E-3 1.782E-2
1.041E-1
 5 370
43 GO:0042886 amide transport 1.671E-4 2.880E-3 2.070E-2
1.238E-1
 5 384
44 GO:0030100 regulation of endocytosis 2.560E-4 4.311E-3 3.098E-2
1.897E-1
 4 226
45 GO:1903861 positive regulation of dendrite extension 3.507E-4 5.649E-3 4.059E-2
2.598E-1
 2 20
46 GO:1903859 regulation of dendrite extension 3.507E-4 5.649E-3 4.059E-2
2.598E-1
 2 20
47 GO:0048488 synaptic vesicle endocytosis 3.872E-4 6.105E-3 4.387E-2
2.869E-1
 2 21
48 GO:0097484 dendrite extension 5.076E-4 7.836E-3
5.631E-2
3.761E-1
 2 24
49 GO:0060384 innervation 5.513E-4 8.337E-3
5.991E-2
4.085E-1
 2 25
50 GO:0006898 receptor-mediated endocytosis 8.532E-4 1.264E-2
9.086E-2
6.322E-1
 4 311
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 26 input genes in category / 117 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0098793 presynapse 6.839E-15 8.001E-13 4.276E-12 8.001E-13 12 341
2 GO:0030133 transport vesicle 8.511E-13 4.979E-11 2.661E-10 9.958E-11 11 374
3 GO:0030658 transport vesicle membrane 2.567E-11 1.001E-9 5.349E-9 3.003E-9 8 158
4 GO:0070382 exocytic vesicle 5.078E-11 1.485E-9 7.937E-9 5.941E-9 8 172
5 GO:0099501 exocytic vesicle membrane 1.828E-10 3.564E-9 1.905E-8 2.139E-8 6 61
6 GO:0030672 synaptic vesicle membrane 1.828E-10 3.564E-9 1.905E-8 2.139E-8 6 61
7 GO:0008021 synaptic vesicle 1.240E-9 2.073E-8 1.108E-7 1.451E-7 7 156
8 GO:0043195 terminal bouton 3.816E-7 5.581E-6 2.982E-5 4.465E-5 5 112
9 GO:0031045 dense core granule 1.247E-6 1.621E-5 8.662E-5 1.459E-4 3 16
10 GO:0033267 axon part 3.029E-6 3.472E-5 1.855E-4 3.544E-4 6 309
11 GO:0042734 presynaptic membrane 3.264E-6 3.472E-5 1.855E-4 3.819E-4 4 76
12 GO:0043679 axon terminus 4.670E-6 4.553E-5 2.433E-4 5.463E-4 5 186
13 GO:0044306 neuron projection terminus 6.491E-6 5.842E-5 3.122E-4 7.595E-4 5 199
14 GO:0030141 secretory granule 1.327E-5 1.109E-4 5.925E-4 1.552E-3 6 400
15 GO:0048786 presynaptic active zone 1.698E-5 1.324E-4 7.075E-4 1.986E-3 3 37
16 GO:0060076 excitatory synapse 2.035E-5 1.488E-4 7.950E-4 2.380E-3 5 252
17 GO:0042584 chromaffin granule membrane 2.675E-5 1.841E-4 9.837E-4 3.129E-3 2 6
18 GO:0097060 synaptic membrane 4.537E-5 2.949E-4 1.576E-3 5.309E-3 5 298
19 GO:0042583 chromaffin granule 6.403E-5 3.943E-4 2.107E-3 7.492E-3 2 9
20 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane 1.858E-4 1.087E-3 5.809E-3 2.174E-2 2 15
21 GO:0030667 secretory granule membrane 2.367E-4 1.318E-3 7.041E-3 2.769E-2 3 89
22 GO:0014069 postsynaptic density 2.590E-4 1.318E-3 7.041E-3 3.030E-2 4 232
23 GO:0099572 postsynaptic specialization 2.590E-4 1.318E-3 7.041E-3 3.030E-2 4 232
24 GO:0098794 postsynapse 3.099E-4 1.511E-3 8.074E-3 3.626E-2 5 449
25 GO:0060077 inhibitory synapse 3.348E-4 1.567E-3 8.374E-3 3.918E-2 2 20
26 GO:1990032 parallel fiber 1.364E-3 6.138E-3 3.280E-2
1.596E-1
 1 1
27 GO:0009898 cytoplasmic side of plasma membrane 1.532E-3 6.640E-3 3.548E-2
1.793E-1
 3 169
28 GO:0055038 recycling endosome membrane 1.709E-3 7.139E-3 3.815E-2
1.999E-1
 2 45
29 GO:0098562 cytoplasmic side of membrane 1.954E-3 7.883E-3 4.212E-2
2.286E-1
 3 184
30 GO:0048788 cytoskeleton of presynaptic active zone 2.726E-3 9.382E-3
5.013E-2
3.190E-1
 1 2
31 GO:0044301 climbing fiber 2.726E-3 9.382E-3
5.013E-2
3.190E-1
 1 2
32 GO:0044317 rod spherule 2.726E-3 9.382E-3
5.013E-2
3.190E-1
 1 2
33 GO:0098831 presynaptic active zone cytoplasmic component 2.726E-3 9.382E-3
5.013E-2
3.190E-1
 1 2
34 GO:0099569 presynaptic cytoskeleton 2.726E-3 9.382E-3
5.013E-2
3.190E-1
 1 2
35 GO:0031594 neuromuscular junction 3.016E-3 1.008E-2
5.388E-2
3.529E-1
 2 60
36 GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane 4.087E-3 1.258E-2
6.724E-2
4.782E-1
 1 3
37 GO:0060200 clathrin-sculpted acetylcholine transport vesicle 4.087E-3 1.258E-2
6.724E-2
4.782E-1
 1 3
38 GO:1990597 AIP1-IRE1 complex 4.087E-3 1.258E-2
6.724E-2
4.782E-1
 1 3
39 GO:0044316 cone cell pedicle 5.445E-3 1.554E-2
8.304E-2
6.371E-1
 1 4
40 GO:0060199 clathrin-sculpted glutamate transport vesicle 5.445E-3 1.554E-2
8.304E-2
6.371E-1
 1 4
41 GO:0060203 clathrin-sculpted glutamate transport vesicle membrane 5.445E-3 1.554E-2
8.304E-2
6.371E-1
 1 4
42 GO:0030665 clathrin-coated vesicle membrane 5.689E-3 1.585E-2
8.469E-2
6.656E-1
 2 83
43 GO:0070081 clathrin-sculpted monoamine transport vesicle 6.802E-3 1.769E-2
9.451E-2
7.959E-1
 1 5
44 GO:0048787 presynaptic active zone membrane 6.802E-3 1.769E-2
9.451E-2
7.959E-1
 1 5
45 GO:0070083 clathrin-sculpted monoamine transport vesicle membrane 6.802E-3 1.769E-2
9.451E-2
7.959E-1
 1 5
46 GO:0032009 early phagosome 8.157E-3 2.031E-2
1.085E-1
9.544E-1
 1 6
47 GO:0030121 AP-1 adaptor complex 8.157E-3 2.031E-2
1.085E-1
9.544E-1
 1 6
48 GO:0044300 cerebellar mossy fiber 9.511E-3 2.318E-2
1.239E-1
1.000E0
 1 7
49 GO:0061202 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane 1.086E-2 2.542E-2
1.358E-1
1.000E0
 1 8
50 GO:0061200 clathrin-sculpted gamma-aminobutyric acid transport vesicle 1.086E-2 2.542E-2
1.358E-1
1.000E0
 1 8
Show 45 more annotations

4: Human Phenotype [Display Chart] 8 input genes in category / 272 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 22 input genes in category / 505 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0002910 abnormal excitatory postsynaptic currents 1.370E-8 6.919E-6 4.707E-5 6.919E-6 7 146
2 MP:0004753 abnormal miniature excitatory postsynaptic currents 4.149E-6 7.034E-4 4.785E-3 2.095E-3 5 119
3 MP:0004792 abnormal synaptic vesicle number 4.179E-6 7.034E-4 4.785E-3 2.110E-3 4 53
4 MP:0004769 abnormal synaptic vesicle morphology 6.891E-6 8.700E-4 5.918E-3 3.480E-3 4 60
5 MP:0002909 abnormal adrenal gland physiology 4.358E-5 4.401E-3 2.994E-2 2.201E-2 3 33
6 MP:0002710 increased glucagon secretion 1.197E-4 1.008E-2
6.855E-2
6.046E-2
 2 8
7 MP:0005445 abnormal neurotransmitter secretion 7.095E-4 3.798E-2
2.584E-1
3.583E-1
 3 84
8 MP:0003565 abnormal glucagon secretion 7.209E-4 3.798E-2
2.584E-1
3.641E-1
 2 19
9 MP:0002916 increased synaptic depression 7.209E-4 3.798E-2
2.584E-1
3.641E-1
 2 19
10 MP:0002945 abnormal inhibitory postsynaptic currents 8.126E-4 3.798E-2
2.584E-1
4.104E-1
 3 88
11 MP:0003563 abnormal pancreatic alpha cell physiology 8.830E-4 3.798E-2
2.584E-1
4.459E-1
 2 21
12 MP:0009538 abnormal synapse morphology 9.025E-4 3.798E-2
2.584E-1
4.558E-1
 4 210
13 MP:0001739 abnormal adrenal gland secretion 1.061E-3 4.122E-2
2.804E-1
5.359E-1
 2 23
Show 8 more annotations

6: Domain [Display Chart] 26 input genes in category / 160 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR000008 C2 dom InterPro 1.800E-42 2.879E-40 1.628E-39 2.879E-40 22 164
2 PF00168 C2 Pfam 6.487E-42 5.190E-40 2.935E-39 1.038E-39 21 131
3 SM00239 C2 SMART 1.794E-41 9.568E-40 5.411E-39 2.871E-39 21 137
4 PS50004 C2 PROSITE 4.039E-41 1.615E-39 9.136E-39 6.462E-39 21 142
5 2.60.40.150 - Gene3D 2.150E-35 6.881E-34 3.892E-33 3.441E-33 19 148
6 IPR001565 Synaptotagmin InterPro 5.182E-19 1.382E-17 7.815E-17 8.291E-17 8 20
7 PS51258 MHD1 PROSITE 1.017E-10 1.627E-9 9.201E-9 1.627E-8 4 7
8 IPR014770 Munc13 1 InterPro 1.017E-10 1.627E-9 9.201E-9 1.627E-8 4 7
9 IPR010439 CAPS dom InterPro 1.017E-10 1.627E-9 9.201E-9 1.627E-8 4 7
10 PF06292 DUF1041 Pfam 1.017E-10 1.627E-9 9.201E-9 1.627E-8 4 7
11 SM01145 DUF1041 SMART 2.368E-8 3.445E-7 1.948E-6 3.789E-6 3 5
12 IPR033227 CAPS InterPro 1.852E-6 2.279E-5 1.289E-4 2.963E-4 2 2
13 IPR015428 Synaptotagmin1 InterPro 1.852E-6 2.279E-5 1.289E-4 2.963E-4 2 2
14 IPR014772 Munc13 dom-2 InterPro 1.847E-5 1.739E-4 9.832E-4 2.956E-3 2 5
15 PF10540 Membr traf MHD Pfam 1.847E-5 1.739E-4 9.832E-4 2.956E-3 2 5
16 IPR019558 Munc13 subgr dom-2 InterPro 1.847E-5 1.739E-4 9.832E-4 2.956E-3 2 5
17 PS51259 MHD2 PROSITE 1.847E-5 1.739E-4 9.832E-4 2.956E-3 2 5
18 IPR019018 Rab-bd FIP-RBD InterPro 2.768E-5 2.215E-4 1.253E-3 4.430E-3 2 6
19 PF09457 RBD-FIP Pfam 2.768E-5 2.215E-4 1.253E-3 4.430E-3 2 6
20 PS51511 FIP RBD PROSITE 2.768E-5 2.215E-4 1.253E-3 4.430E-3 2 6
21 SM00233 PH SMART 3.597E-5 2.589E-4 1.464E-3 5.755E-3 5 279
22 PS50003 PH DOMAIN PROSITE 3.659E-5 2.589E-4 1.464E-3 5.854E-3 5 280
23 IPR001849 PH domain InterPro 3.722E-5 2.589E-4 1.464E-3 5.954E-3 5 281
24 IPR010911 Rab BD InterPro 1.212E-4 7.756E-4 4.386E-3 1.939E-2 2 12
25 PS50916 RABBD PROSITE 1.212E-4 7.756E-4 4.386E-3 1.939E-2 2 12
26 IPR023152 RasGAP CS InterPro 1.668E-4 9.885E-4 5.590E-3 2.669E-2 2 14
27 SM00323 RasGAP SMART 1.668E-4 9.885E-4 5.590E-3 2.669E-2 2 14
28 2.30.29.30 - Gene3D 1.768E-4 9.926E-4 5.613E-3 2.829E-2 5 391
29 PS00509 RAS GTPASE ACTIV 1 PROSITE 1.923E-4 9.926E-4 5.613E-3 3.077E-2 2 15
30 PF00616 RasGAP Pfam 1.923E-4 9.926E-4 5.613E-3 3.077E-2 2 15
31 PS50018 RAS GTPASE ACTIV 2 PROSITE 1.923E-4 9.926E-4 5.613E-3 3.077E-2 2 15
32 1.10.506.10 - Gene3D 2.196E-4 1.098E-3 6.210E-3 3.513E-2 2 16
33 IPR011993 PH dom-like InterPro 2.661E-4 1.259E-3 7.120E-3 4.257E-2 5 427
34 PF00169 PH Pfam 2.675E-4 1.259E-3 7.120E-3 4.281E-2 4 230
35 IPR001936 RasGAP dom InterPro 2.795E-4 1.278E-3 7.226E-3 4.472E-2 2 18
36 PS50237 HECT PROSITE 6.363E-4 2.610E-3 1.476E-2
1.018E-1
 2 27
37 IPR000569 HECT dom InterPro 6.363E-4 2.610E-3 1.476E-2
1.018E-1
 2 27
38 SM00119 HECTc SMART 6.363E-4 2.610E-3 1.476E-2
1.018E-1
 2 27
39 PF00632 HECT Pfam 6.363E-4 2.610E-3 1.476E-2
1.018E-1
 2 27
40 IPR015427 Synaptotagmin7 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
41 IPR028378 Sytl1 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
42 IPR028699 SYT11 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
43 IPR030629 Piccolo InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
44 IPR028473 EYA2 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
45 IPR031134 RPGRIP1 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
46 IPR028691 SYT9 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
47 IPR028381 PLC-gamma2 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
48 IPR030403 DAB2IP InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
49 IPR028698 RPH3A InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
50 IPR030543 Syt2 InterPro 1.388E-3 4.441E-3 2.512E-2
2.220E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 21 input genes in category / 272 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P05734 Synaptic vesicle trafficking PantherDB 2.697E-10 7.335E-8 4.536E-7 7.335E-8 5 23
2 1427850 Interactions of neurexins and neuroligins at synapses BioSystems: REACTOME 2.563E-6 2.401E-4 1.485E-3 6.972E-4 4 59
3 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 2.648E-6 2.401E-4 1.485E-3 7.204E-4 5 137
4 1427849 Protein-protein interactions at synapses BioSystems: REACTOME 6.037E-6 4.105E-4 2.539E-3 1.642E-3 4 73
5 1269147 Toxicity of botulinum toxin type B (BoNT/B) BioSystems: REACTOME 8.121E-6 4.418E-4 2.732E-3 2.209E-3 2 3
6 1268763 Neuronal System BioSystems: REACTOME 1.824E-5 7.885E-4 4.877E-3 4.961E-3 6 351
7 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 2.029E-5 7.885E-4 4.877E-3 5.520E-3 4 99
8 102279 Endocytosis BioSystems: KEGG 5.913E-5 2.011E-3 1.243E-2 1.608E-2 5 260
9 138028 Effects of Botulinum toxin BioSystems: Pathway Interaction Database 9.686E-5 2.927E-3 1.811E-2 2.635E-2 2 9
10 1269145 Neurotoxicity of clostridium toxins BioSystems: REACTOME 1.210E-4 3.290E-3 2.035E-2 3.290E-2 2 10
11 1268773 Acetylcholine Neurotransmitter Release Cycle BioSystems: REACTOME 3.630E-4 7.925E-3 4.902E-2
9.872E-2
 2 17
12 PW:0000674 insulin secretion pathway Pathway Ontology 4.079E-4 7.925E-3 4.902E-2
1.110E-1
 2 18
13 1268769 Norepinephrine Neurotransmitter Release Cycle BioSystems: REACTOME 4.079E-4 7.925E-3 4.902E-2
1.110E-1
 2 18
14 1268770 Serotonin Neurotransmitter Release Cycle BioSystems: REACTOME 4.079E-4 7.925E-3 4.902E-2
1.110E-1
 2 18
15 1268772 Dopamine Neurotransmitter Release Cycle BioSystems: REACTOME 6.711E-4 1.217E-2
7.527E-2
1.825E-1
 2 23
16 1268771 Glutamate Neurotransmitter Release Cycle BioSystems: REACTOME 7.314E-4 1.243E-2
7.690E-2
1.989E-1
 2 24
17 P00018 EGF receptor signaling pathway PantherDB 8.160E-4 1.306E-2
8.075E-2
2.220E-1
 3 111
18 1383029 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases BioSystems: REACTOME 9.976E-4 1.507E-2
9.323E-2
2.713E-1
 2 28
19 1269144 Uptake and actions of bacterial toxins BioSystems: REACTOME 1.223E-3 1.751E-2
1.083E-1
3.328E-1
 2 31
20 P04385 Histamine H1 receptor mediated signaling pathway PantherDB 2.240E-3 3.047E-2
1.884E-1
6.093E-1
 2 42
21 P00060 Ubiquitin proteasome pathway PantherDB 2.568E-3 3.326E-2
2.057E-1
6.985E-1
 2 45
22 1269284 DAP12 signaling BioSystems: REACTOME 2.758E-3 3.410E-2
2.109E-1
7.501E-1
 4 359
23 1269283 DAP12 interactions BioSystems: REACTOME 3.197E-3 3.439E-2
2.127E-1
8.697E-1
 4 374
24 1268768 Neurotransmitter Release Cycle BioSystems: REACTOME 3.287E-3 3.439E-2
2.127E-1
8.941E-1
 2 51
25 1457782 Signaling by RAS mutants BioSystems: REACTOME 3.287E-3 3.439E-2
2.127E-1
8.941E-1
 2 51
26 138024 TGF-beta receptor signaling BioSystems: Pathway Interaction Database 3.287E-3 3.439E-2
2.127E-1
8.941E-1
 2 51
27 P04391 Oxytocin receptor mediated signaling pathway PantherDB 3.813E-3 3.837E-2
2.373E-1
1.000E0
 2 55
28 P00056 VEGF signaling pathway PantherDB 4.232E-3 3.837E-2
2.373E-1
1.000E0
 2 58
29 83119 Non-small cell lung cancer BioSystems: KEGG 4.232E-3 3.837E-2
2.373E-1
1.000E0
 2 58
30 P04394 Thyrotropin-releasing hormone receptor signaling pathway PantherDB 4.232E-3 3.837E-2
2.373E-1
1.000E0
 2 58
31 83066 VEGF signaling pathway BioSystems: KEGG 4.376E-3 3.839E-2
2.375E-1
1.000E0
 2 59
32 P04374 5HT2 type receptor mediated signaling pathway PantherDB 4.974E-3 3.986E-2
2.466E-1
1.000E0
 2 63
33 373900 Synaptic vesicle cycle BioSystems: KEGG 4.974E-3 3.986E-2
2.466E-1
1.000E0
 2 63
34 1269153 Toxicity of botulinum toxin type G (BoNT/G) BioSystems: REACTOME 5.052E-3 3.986E-2
2.466E-1
1.000E0
 1 3
35 83110 Glioma BioSystems: KEGG 5.130E-3 3.986E-2
2.466E-1
1.000E0
 2 64
36 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 5.580E-3 4.216E-2
2.607E-1
1.000E0
 3 218
37 1383025 Signaling by PTK6 BioSystems: REACTOME 5.773E-3 4.244E-2
2.625E-1
1.000E0
 2 68
38 868085 Ras signaling pathway BioSystems: KEGG 6.242E-3 4.468E-2
2.763E-1
1.000E0
 3 227
39 1269290 Regulation of RAS by GAPs BioSystems: REACTOME 6.626E-3 4.621E-2
2.858E-1
1.000E0
 2 73
40 1457781 Oncogenic MAPK signaling BioSystems: REACTOME 7.164E-3 4.871E-2
3.013E-1
1.000E0
 2 76
Show 35 more annotations

8: Pubmed [Display Chart] 26 input genes in category / 1960 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8901523 Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin. Pubmed 2.443E-14 4.788E-11 3.906E-10 4.788E-11 5 10
2 10734137 SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. Pubmed 7.670E-14 7.517E-11 6.132E-10 1.503E-10 5 12
3 29068313 Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis. Pubmed 1.686E-13 1.102E-10 8.989E-10 3.306E-10 4 4
4 25609709 Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells. Pubmed 1.178E-11 5.774E-9 4.711E-8 2.310E-8 4 8
5 14715936 The secretory granule-associated protein CAPS2 regulates neurotrophin release and cell survival. Pubmed 3.532E-11 1.154E-8 9.412E-8 6.922E-8 4 10
6 21040848 SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming. Pubmed 3.532E-11 1.154E-8 9.412E-8 6.922E-8 4 10
7 25374362 The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones. Pubmed 5.548E-11 1.553E-8 1.267E-7 1.087E-7 4 11
8 20926654 Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells. Pubmed 1.120E-9 2.438E-7 1.989E-6 2.194E-6 3 4
9 19234085 Zea mays annexins modulate cytosolic free Ca2+ and generate a Ca2+-permeable conductance. Pubmed 1.120E-9 2.438E-7 1.989E-6 2.194E-6 3 4
10 17124501 Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release. Pubmed 1.776E-9 3.480E-7 2.839E-6 3.480E-6 4 24
11 29274147 Doc2B acts as a calcium sensor for vesicle priming requiring synaptotagmin-1, Munc13-2 and SNAREs. Pubmed 2.798E-9 4.985E-7 4.067E-6 5.484E-6 3 5
12 12860971 Identification of synaptotagmin effectors via acute inhibition of secretion from cracked PC12 cells. Pubmed 5.593E-9 8.433E-7 6.879E-6 1.096E-5 3 6
13 15350218 WNK1 phosphorylates synaptotagmin 2 and modulates its membrane binding. Pubmed 5.593E-9 8.433E-7 6.879E-6 1.096E-5 3 6
14 16407767 Distinct developmental expression of synaptotagmin I and IX in the mouse brain. Pubmed 2.346E-8 3.065E-6 2.501E-5 4.598E-5 3 9
15 10531343 Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. Pubmed 2.346E-8 3.065E-6 2.501E-5 4.598E-5 3 9
16 15820695 CAPS1 regulates catecholamine loading of large dense-core vesicles. Pubmed 3.350E-8 4.103E-6 3.348E-5 6.566E-5 3 10
17 11543631 Genomic analysis of synaptotagmin genes. Pubmed 7.973E-8 9.192E-6 7.499E-5 1.563E-4 3 13
18 12693553 Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Pubmed 2.277E-7 2.426E-5 1.979E-4 4.463E-4 6 395
19 7961887 Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
20 24267651 Synaptotagmin-1 and synaptotagmin-7 trigger synchronous and asynchronous phases of neurotransmitter release. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
21 22966849 Hydrophobic contributions to the membrane docking of synaptotagmin 7 C2A domain: mechanistic contrast between isoforms 1 and 7. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
22 18495893 CAPS facilitates filling of the rapidly releasable pool of large dense-core vesicles. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
23 23648184 Synaptotagmins 1 and 2 as mediators of rapid exocytosis at nerve terminals: the dyad hypothesis. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
24 27997124 Differential Membrane Binding Mechanics of Synaptotagmin Isoforms Observed in Atomic Detail. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
25 17492637 Synaptotagmin I and II are present in distinct subsets of central synapses. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
26 24302762 Structural insights into the Ca2+ and PI(4,5)P2 binding modes of the C2 domains of rabphilin 3A and synaptotagmin 1. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
27 28355182 Postsynaptic synaptotagmins mediate AMPA receptor exocytosis during LTP. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
28 14504267 Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
29 2446925 The N-terminal half of the heavy chain of botulinum type A neurotoxin forms channels in planar phospholipid bilayers. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
30 15123599 Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
31 18308932 Synaptotagmin-1 and -7 are functionally overlapping Ca2+ sensors for exocytosis in adrenal chromaffin cells. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
32 28883501 CAPS-1 requires its C2, PH, MHD1 and DCV domains for dense core vesicle exocytosis in mammalian CNS neurons. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
33 20824061 Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
34 25719439 CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
35 28363983 Synaptotagmin2 (Syt2) Drives Fast Release Redundantly with Syt1 at the Output Synapses of Parvalbumin-Expressing Inhibitory Neurons. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
36 20855507 Two distinct secretory vesicle-priming steps in adrenal chromaffin cells. Pubmed 4.456E-7 2.426E-5 1.979E-4 8.734E-4 2 2
37 17521570 Synaptotagmin-1, -2, and -9: Ca(2+) sensors for fast release that specify distinct presynaptic properties in subsets of neurons. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
38 25437547 Secretory vesicle priming by CAPS is independent of its SNARE-binding MUN domain. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
39 20473299 Synaptotagmin-mediated vesicle fusion regulates cell migration. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
40 14530279 A family of Ca2+-dependent activator proteins for secretion: comparative analysis of structure, expression, localization, and function. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
41 25051198 Bortezomib prevents oncogenesis and bone metastasis of prostate cancer by inhibiting WWP1, Smurf1 and Smurf2. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
42 18177725 CAPS1 and CAPS2 regulate stability and recruitment of insulin granules in mouse pancreatic beta cells. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
43 18158333 Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
44 12062043 Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
45 15857609 Regulation of dense core vesicle release from PC12 cells by interaction between the D2 dopamine receptor and calcium-dependent activator protein for secretion (CAPS). Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
46 12659812 Cloning and characterization of human CADPS and CADPS2, new members of the Ca2+-dependent activator for secretion protein family. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
47 12526776 Sr2+ binding to the Ca2+ binding site of the synaptotagmin 1 C2B domain triggers fast exocytosis without stimulating SNARE interactions. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
48 14709554 Synaptotagmin interaction with the syntaxin/SNAP-25 dimer is mediated by an evolutionarily conserved motif and is sensitive to inositol hexakisphosphate. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
49 26202512 Synaptotagmins interact with APP and promote Aβ generation. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
50 18022372 CAPS-1 and CAPS-2 are essential synaptic vesicle priming proteins. Pubmed 1.336E-6 4.762E-5 3.885E-4 2.619E-3 2 3
Show 45 more annotations

9: Interaction [Display Chart] 26 input genes in category / 823 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NRXN1 NRXN1 interactions 1.703E-11 1.402E-8 1.022E-7 1.402E-8 6 39
2 int:STX2 STX2 interactions 3.675E-6 1.512E-3 1.103E-2 3.025E-3 3 21
3 int:RAB25 RAB25 interactions 6.331E-6 1.737E-3 1.266E-2 5.210E-3 3 25
4 int:RAB27A RAB27A interactions 1.490E-5 2.600E-3 1.896E-2 1.226E-2 3 33
5 int:CGN CGN interactions 1.580E-5 2.600E-3 1.896E-2 1.300E-2 4 105
6 int:DOC2B DOC2B interactions 3.100E-5 4.252E-3 3.100E-2 2.551E-2 2 6
7 int:AATK AATK interactions 6.637E-5 7.804E-3
5.689E-2
5.463E-2
 3 54
8 int:SYT2 SYT2 interactions 1.132E-4 1.057E-2
7.710E-2
9.313E-2
 2 11
9 int:SNAP25 SNAP25 interactions 1.156E-4 1.057E-2
7.710E-2
9.517E-2
 3 65
10 int:STX1A STX1A interactions 1.841E-4 1.397E-2
1.018E-1
1.515E-1
 3 76
11 int:CCDC28A CCDC28A interactions 1.867E-4 1.397E-2
1.018E-1
1.537E-1
 2 14
12 int:TFAP2A TFAP2A interactions 2.144E-4 1.470E-2
1.072E-1
1.764E-1
 3 80
13 int:RAB11FIP4 RAB11FIP4 interactions 2.458E-4 1.556E-2
1.134E-1
2.023E-1
 2 16
14 int:SYNCRIP SYNCRIP interactions 2.798E-4 1.609E-2
1.173E-1
2.303E-1
 5 408
15 int:DAB2 DAB2 interactions 2.937E-4 1.609E-2
1.173E-1
2.417E-1
 3 89
16 int:RAB27B RAB27B interactions 3.128E-4 1.609E-2
1.173E-1
2.574E-1
 2 18
17 int:FBXL15 FBXL15 interactions 3.877E-4 1.877E-2
1.369E-1
3.191E-1
 2 20
18 int:MAPK1IP1L MAPK1IP1L interactions 7.658E-4 3.382E-2
2.466E-1
6.303E-1
 2 28
19 int:LAPTM5 LAPTM5 interactions 8.218E-4 3.382E-2
2.466E-1
6.764E-1
 2 29
20 int:RIMS1 RIMS1 interactions 8.218E-4 3.382E-2
2.466E-1
6.764E-1
 2 29
21 int:TP63 TP63 interactions 9.498E-4 3.722E-2
2.714E-1
7.817E-1
 3 133
22 int:RAB11FIP5 RAB11FIP5 interactions 1.198E-3 4.481E-2
3.267E-1
9.859E-1
 2 35
23 int:DRD2 DRD2 interactions 1.267E-3 4.534E-2
3.306E-1
1.000E0
 2 36
24 int:STON2 STON2 interactions 1.338E-3 4.590E-2
3.346E-1
1.000E0
 2 37
25 int:CBY1 CBY1 interactions 1.422E-3 4.682E-2
3.414E-1
1.000E0
 3 153
26 int:CLIP1 CLIP1 interactions 1.486E-3 4.705E-2
3.430E-1
1.000E0
 2 39
27 int:SPART SPART interactions 1.563E-3 4.765E-2
3.474E-1
1.000E0
 2 40
Show 22 more annotations

10: Cytoband [Display Chart] 25 input genes in category / 24 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7q11.23-q21.3 7q11.23-q21.3 7.213E-4 8.655E-3 3.268E-2 1.731E-2 1 1
2 9q33.1-q33.3 9q33.1-q33.3 7.213E-4 8.655E-3 3.268E-2 1.731E-2 1 1
3 1q32.1 1q32.1 3.062E-3 2.074E-2
7.830E-2
7.348E-2
 2 114
4 17q22-q23 17q22-q23 4.320E-3 2.074E-2
7.830E-2
1.037E-1
 1 6
5 11q12-q13.1 11q12-q13.1 4.320E-3 2.074E-2
7.830E-2
1.037E-1
 1 6
6 20q13.1 20q13.1 7.190E-3 2.876E-2
1.086E-1
1.726E-1
 1 10
7 8q21 8q21 8.622E-3 2.927E-2
1.105E-1
2.069E-1
 1 12
8 7q31.3 7q31.3 1.077E-2 2.927E-2
1.105E-1
2.584E-1
 1 15
9 10q26.11 10q26.11 1.148E-2 2.927E-2
1.105E-1
2.755E-1
 1 16
10 3p14.2 3p14.2 1.219E-2 2.927E-2
1.105E-1
2.927E-1
 1 17
11 2p13 2p13 1.717E-2 3.747E-2
1.415E-1
4.122E-1
 1 24
12 12q24.13 12q24.13 1.930E-2 3.860E-2
1.458E-1
4.632E-1
 1 27
13 16q24.1 16q24.1 2.565E-2 4.398E-2
1.661E-1
6.157E-1
 1 36
14 2p14 2p14 2.565E-2 4.398E-2
1.661E-1
6.157E-1
 1 36
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 18 input genes in category / 180 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 25 input genes in category / 18 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 823 C2 domain containing|Calpains genenames.org 2.992E-14 5.386E-13 1.882E-12 5.386E-13 7 36
2 765 Synaptotagmins genenames.org 1.958E-11 1.763E-10 6.160E-10 3.525E-10 5 17
3 830 Pleckstrin homology domain containing|C2 and RasGAP domain containing genenames.org 8.102E-5 3.646E-4 1.274E-3 1.458E-3 2 10
4 822 Synaptotagmin like tandem C2 proteins genenames.org 8.102E-5 3.646E-4 1.274E-3 1.458E-3 2 10
5 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 2.738E-3 9.856E-3 3.445E-2 4.928E-2 3 206
6 713 Class III Cys-based CDC25 phosphatases genenames.org 4.117E-3 1.097E-2 3.834E-2
7.410E-2
 1 3
7 836 UNC13 homologs genenames.org 5.485E-3 1.097E-2 3.834E-2
9.874E-2
 1 4
8 838 C2 and WW domain containing genenames.org 5.485E-3 1.097E-2 3.834E-2
9.874E-2
 1 4
9 1044 EYA transcriptional coactivator and phosphatases genenames.org 5.485E-3 1.097E-2 3.834E-2
9.874E-2
 1 4
10 837 SH2 domain containing|C2 tensin-type domain containing|PTEN protein phosphatases genenames.org 1.094E-2 1.970E-2
6.884E-2
1.970E-1
 1 8
11 835 C2 domain containing protein kinases genenames.org 1.366E-2 2.235E-2
7.812E-2
2.459E-1
 1 10
12 26 Zinc fingers genenames.org 2.042E-2 3.063E-2
1.071E-1
3.676E-1
 1 15
13 812 Protein tyrosine phosphatases, non-receptor type|FERM domain containing genenames.org 2.446E-2 3.317E-2
1.159E-1
4.402E-1
 1 18
14 832 Phospholipases|C2 domain containing phospholipases genenames.org 2.580E-2 3.317E-2
1.159E-1
4.644E-1
 1 19
Show 9 more annotations

13: Coexpression [Display Chart] 26 input genes in category / 2167 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17761679-Table1 Mouse Pancreas Keller07 85genes GeneSigDB 1.092E-6 2.366E-3 1.954E-2 2.366E-3 4 70
2 M7728 Genes up-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 1h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 2.853E-5 2.803E-2
2.315E-1
6.183E-2
 4 159
3 M12892 Genes up-regulated in the luminal B subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.880E-5 2.803E-2
2.315E-1
8.408E-2
 4 172
4 M8320 Genes up-regulated in CD4 [GeneID=920] T cells: naïve versus activated. MSigDB C7: Immunologic Signatures (v6.0) 6.978E-5 2.826E-2
2.334E-1
1.512E-1
 4 200
5 M8311 Genes down-regulated in naïve T cells: CD4 [GeneID=920] versus NK. MSigDB C7: Immunologic Signatures (v6.0) 6.978E-5 2.826E-2
2.334E-1
1.512E-1
 4 200
6 M2284 Transcripts down-regulated by overexpression of MIR16 family of microRNA molecules in DLD-1 and HCT116 (colon cancer) cells hypomorphic for DICER1 [GeneID=23405]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.825E-5 2.826E-2
2.334E-1
1.696E-1
 4 206
Show 1 more annotation

14: Coexpression Atlas [Display Chart] 26 input genes in category / 1693 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup3 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup3 Top 200 Genes BrainMap 3.120E-8 1.814E-5 1.453E-4 5.281E-5 7 284
2 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Slc17a6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Slc17a6 Top 200 Genes BrainMap 4.645E-8 1.814E-5 1.453E-4 7.864E-5 7 301
3 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Overall Top 200 Genes BrainMap 6.000E-8 1.814E-5 1.453E-4 1.016E-4 6 181
4 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Gad1,Gad2 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Gad1,Gad2 Top 200 Genes 6.617E-8 1.814E-5 1.453E-4 1.120E-4 7 317
5 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup2 Top 200 Genes BrainMap 7.362E-8 1.814E-5 1.453E-4 1.246E-4 7 322
6 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.inhibitory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.inhibitory Top 200 Genes BrainMap 7.680E-8 1.814E-5 1.453E-4 1.300E-4 7 324
7 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup7 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup7 Top 200 Genes BrainMap 9.054E-8 1.814E-5 1.453E-4 1.533E-4 6 194
8 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup1 Top 200 Genes BrainMap 9.641E-8 1.814E-5 1.453E-4 1.632E-4 7 335
9 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Th Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Th Top 200 Genes BrainMap 9.641E-8 1.814E-5 1.453E-4 1.632E-4 7 335
10 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup8 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup8 Top 200 Genes BrainMap 1.447E-7 2.330E-5 1.867E-4 2.450E-4 6 210
11 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Slc17a6 Top 200 Genes 1.514E-7 2.330E-5 1.867E-4 2.563E-4 7 358
12 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup8 Inhibitory.subGroup8 Subtype Inhibitory.subGroup8 Thalamus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup8 Inhibitory.subGroup8 Subtype Inhibitory.subGroup8 Thalamus Top 200 Genes BrainMap 4.967E-7 7.008E-5 5.615E-4 8.410E-4 6 259
13 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup5 Top 200 Genes BrainMap 6.474E-7 8.431E-5 6.754E-4 1.096E-3 6 271
14 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup4 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup4 Top 200 Genes BrainMap 1.083E-6 1.127E-4 9.026E-4 1.833E-3 6 296
15 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Sncg,Yjefn3,Slc17a8 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Sncg,Yjefn3,Slc17a8 Top 200 Genes BrainMap 1.171E-6 1.127E-4 9.026E-4 1.982E-3 6 300
16 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes 1.194E-6 1.127E-4 9.026E-4 2.021E-3 6 301
17 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap 1.194E-6 1.127E-4 9.026E-4 2.021E-3 6 301
18 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Slc17a7 Top 200 Genes 1.240E-6 1.127E-4 9.026E-4 2.100E-3 6 303
19 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Sncg Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Sncg Top 200 Genes BrainMap 1.264E-6 1.127E-4 9.026E-4 2.141E-3 6 304
20 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap 1.470E-6 1.232E-4 9.868E-4 2.489E-3 6 312
21 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Gad1,Gad2 Top 200 Genes BrainMap 1.642E-6 1.232E-4 9.868E-4 2.780E-3 6 318
22 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup6 Top 200 Genes BrainMap 1.703E-6 1.232E-4 9.868E-4 2.883E-3 6 320
23 BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Subtype Neuron.excitatory.Slc17a7.Parm1 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Subtype Neuron.excitatory.Slc17a7.Parm1 FrontalCortex Top 200 Genes BrainMap 1.896E-6 1.232E-4 9.868E-4 3.210E-3 6 326
24 BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Top 200 BrainMap BrainAtlas - Mouse McCarroll FrontalCortex FrontalCortex Top 200 BrainMap 1.896E-6 1.232E-4 9.868E-4 3.210E-3 6 326
25 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb Top 200 Genes BrainMap 1.930E-6 1.232E-4 9.868E-4 3.267E-3 6 327
26 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup9 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Inhibitory.subGroup9 Top 200 Genes BrainMap 1.964E-6 1.232E-4 9.868E-4 3.326E-3 6 328
27 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Th Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Th Top 200 Genes 1.964E-6 1.232E-4 9.868E-4 3.326E-3 6 328
28 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Nefm Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Nefm Top 200 Genes BrainMap 2.220E-6 1.322E-4 1.059E-3 3.758E-3 6 335
29 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Overall Top 200 Genes BrainMap 2.421E-6 1.322E-4 1.059E-3 4.099E-3 5 186
30 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Overall Top 200 Genes 2.421E-6 1.322E-4 1.059E-3 4.099E-3 5 186
31 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron BrainMap 2.421E-6 1.322E-4 1.059E-3 4.099E-3 5 186
32 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Subtype iProg1 Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Subtype iProg1 Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 2.544E-6 1.346E-4 1.078E-3 4.306E-3 6 343
33 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC iProg Overall Top 200 Genes GSE76381_iPSMoleculeCountsPMLog2 2.757E-6 1.400E-4 1.122E-3 4.668E-3 5 191
34 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cplx3,Npy Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cplx3,Npy Top 200 Genes BrainMap 2.811E-6 1.400E-4 1.122E-3 4.760E-3 6 349
35 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6 Top 200 Genes 3.308E-6 1.600E-4 1.282E-3 5.601E-3 6 359
36 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cadm2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cadm2 Top 200 Genes BrainMap 5.747E-6 2.703E-4 2.165E-3 9.730E-3 5 222
37 GSM605796 500 gamma delta T cells, Tgd.vg2-.Sp.TCRbko, TCRd+ Vg2- CD44-, Spleen, avg-3 Immgen.org, GSE15907 6.607E-6 3.023E-4 2.422E-3 1.119E-2 6 405
38 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup5 Top 200 Genes BrainMap 1.331E-5 5.930E-4 4.751E-3 2.253E-2 5 264
39 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Sst,Nr2f2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Sst,Nr2f2 Top 200 Genes BrainMap 1.457E-5 6.278E-4 5.030E-3 2.467E-2 5 269
40 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Ttn Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Ttn Top 200 Genes BrainMap 1.483E-5 6.278E-4 5.030E-3 2.511E-2 5 270
41 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Unc5b Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Pvalb,Unc5b Top 200 Genes BrainMap 1.620E-5 6.691E-4 5.361E-3 2.743E-2 5 275
42 gudmap dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k4 1000 dev lower uro neuro e15.5 BladdPelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.737E-5 7.002E-4 5.610E-3 2.941E-2 5 279
43 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cbln1,Slc17a6 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Cbln1,Slc17a6 Top 200 Genes BrainMap 1.798E-5 7.037E-4 5.638E-3 3.044E-2 5 281
44 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Nr4a2,Th Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Nr4a2,Th Top 200 Genes BrainMap 1.829E-5 7.037E-4 5.638E-3 3.096E-2 5 282
45 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Six3,Pvalb Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Six3,Pvalb Top 200 Genes BrainMap 2.024E-5 7.573E-4 6.067E-3 3.426E-2 5 288
46 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Nnat Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Synpr,Nnat Top 200 Genes BrainMap 2.058E-5 7.573E-4 6.067E-3 3.483E-2 5 289
47 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap 2.162E-5 7.604E-4 6.092E-3 3.660E-2 5 292
48 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Sst,Crh Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Subtype Neuron.inhibitory.Gad1,Gad2.Sst,Crh Top 200 Genes BrainMap 2.162E-5 7.604E-4 6.092E-3 3.660E-2 5 292
49 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 k4 200 dev lower uro neuro e14.5 PelvicGanglion Sox10 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 2.201E-5 7.604E-4 6.092E-3 3.726E-2 3 46
50 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a8 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a8 Top 200 Genes 2.346E-5 7.942E-4 6.363E-3 3.971E-2 5 297
Show 45 more annotations

15: Computational [Display Chart] 20 input genes in category / 105 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3373 GNF2 DNM1 Neighborhood of DNM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.850E-4 2.047E-2
1.072E-1
 4.043E-2 3 73
2 M10977 MODULE 563 Genes in the cancer module 563. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.900E-4 2.047E-2
1.072E-1
 4.095E-2 2 15
3 M4337 MODULE 177 Genes in the cancer module 177. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.956E-4 3.485E-2
1.824E-1
1.045E-1
 3 101

16: MicroRNA [Display Chart] 26 input genes in category / 841 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-767-3p:PITA hsa-miR-767-3p:PITA TOP PITA 1.361E-8 1.145E-5 8.370E-5 1.145E-5 5 214
2 hsa-miR-584:PITA hsa-miR-584:PITA TOP PITA 5.955E-7 2.504E-4 1.831E-3 5.008E-4 4 185
3 hsa-miR-1276:PITA hsa-miR-1276:PITA TOP PITA 6.874E-6 1.927E-3 1.409E-2 5.781E-3 4 343
4 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 1.071E-5 2.237E-3 1.636E-2 9.008E-3 4 384
5 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.793E-5 2.237E-3 1.636E-2 1.508E-2 4 438
6 hsa-miR-520f:PITA hsa-miR-520f:PITA TOP PITA 2.027E-5 2.237E-3 1.636E-2 1.705E-2 4 452
7 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 2.116E-5 2.237E-3 1.636E-2 1.780E-2 4 457
8 hsa-miR-875-3p:PITA hsa-miR-875-3p:PITA TOP PITA 2.134E-5 2.237E-3 1.636E-2 1.795E-2 4 458
9 hsa-miR-6826-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.524E-5 2.237E-3 1.636E-2 2.122E-2 3 157
10 hsa-miR-432:PITA hsa-miR-432:PITA TOP PITA 2.670E-5 2.237E-3 1.636E-2 2.246E-2 3 160
11 hsa-miR-4455:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.927E-5 2.237E-3 1.636E-2 2.461E-2 3 165
12 hsa-miR-1178:PITA hsa-miR-1178:PITA TOP PITA 3.312E-5 2.321E-3 1.697E-2 2.785E-2 3 172
13 hsa-miR-1183:PITA hsa-miR-1183:PITA TOP PITA 5.033E-5 3.069E-3 2.244E-2 4.233E-2 3 198
14 hsa-miR-630:PITA hsa-miR-630:PITA TOP PITA 5.109E-5 3.069E-3 2.244E-2 4.296E-2 3 199
15 TAATAAT,MIR-126:MSigDB TAATAAT,MIR-126:MSigDB MSigDB 5.579E-5 3.128E-3 2.287E-2 4.692E-2 3 205
16 hsa-miR-516a-3p:PITA hsa-miR-516a-3p:PITA TOP PITA 6.163E-5 3.240E-3 2.369E-2
5.183E-2
 3 212
17 hsa-miR-202:PITA hsa-miR-202:PITA TOP PITA 7.065E-5 3.301E-3 2.414E-2
5.942E-2
 3 222
18 hsa-miR-892b:PITA hsa-miR-892b:PITA TOP PITA 7.065E-5 3.301E-3 2.414E-2
5.942E-2
 3 222
19 hsa-miR-3907:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.115E-4 4.933E-3 3.607E-2
9.373E-2
 2 43
20 ACTTTAT,MIR-142-5P:MSigDB ACTTTAT,MIR-142-5P:MSigDB MSigDB 1.315E-4 5.382E-3 3.935E-2
1.106E-1
 3 274
21 hsa-miR-624:PITA hsa-miR-624:PITA TOP PITA 1.344E-4 5.382E-3 3.935E-2
1.130E-1
 3 276
22 hsa-miR-8065:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.477E-4 9.468E-3
6.923E-2
2.083E-1
 2 64
23 hsa-miR-615-5p:PITA hsa-miR-615-5p:PITA TOP PITA 2.634E-4 9.631E-3
7.043E-2
2.215E-1
 2 66
24 hsa-miR-323a-3p:TargetScan hsa-miR-323a-3p TargetScan 2.978E-4 1.044E-2
7.631E-2
2.505E-1
 3 362
25 hsa-miR-518e:mirSVR lowEffct hsa-miR-518e:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 4.073E-4 1.370E-2
1.002E-1
3.425E-1
 3 403
26 hsa-miR-1299:PITA hsa-miR-1299:PITA TOP PITA 4.312E-4 1.395E-2
1.020E-1
3.627E-1
 3 411
27 hsa-miR-6795-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.563E-4 1.691E-2
1.237E-1
4.678E-1
 2 96
28 hsa-miR-409-5p:TargetScan hsa-miR-409-5p TargetScan 5.678E-4 1.691E-2
1.237E-1
4.776E-1
 2 97
29 hsa-miR-635:PITA hsa-miR-635:PITA TOP PITA 6.033E-4 1.691E-2
1.237E-1
5.074E-1
 2 100
30 hsa-miR-5683:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.033E-4 1.691E-2
1.237E-1
5.074E-1
 2 100
31 hsa-miR-210:mirSVR lowEffct hsa-miR-210:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 7.138E-4 1.936E-2
1.416E-1
6.003E-1
 3 489
32 hsa-miR-6748-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.664E-4 2.179E-2
1.593E-1
7.286E-1
 2 120
33 hsa-miR-127-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.664E-4 2.179E-2
1.593E-1
7.286E-1
 2 120
34 hsa-miR-4452:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.807E-4 2.179E-2
1.593E-1
7.407E-1
 2 121
35 hsa-miR-1262:PITA hsa-miR-1262:PITA TOP PITA 1.031E-3 2.477E-2
1.811E-1
8.668E-1
 2 131
36 GACAATC,MIR-219:MSigDB GACAATC,MIR-219:MSigDB MSigDB 1.078E-3 2.518E-2
1.841E-1
9.065E-1
 2 134
37 hsa-miR-626:PITA hsa-miR-626:PITA TOP PITA 1.159E-3 2.634E-2
1.926E-1
9.746E-1
 2 139
38 hsa-miR-8064:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.192E-3 2.638E-2
1.929E-1
1.000E0
 2 141
39 TCCAGAG,MIR-518C:MSigDB TCCAGAG,MIR-518C:MSigDB MSigDB 1.226E-3 2.643E-2
1.933E-1
1.000E0
 2 143
40 hsa-miR-629:PITA hsa-miR-629:PITA TOP PITA 1.401E-3 2.910E-2
2.128E-1
1.000E0
 2 153
41 hsa-miR-708:PITA hsa-miR-708:PITA TOP PITA 1.419E-3 2.910E-2
2.128E-1
1.000E0
 2 154
42 hsa-miR-28-5p:PITA hsa-miR-28-5p:PITA TOP PITA 1.455E-3 2.914E-2
2.131E-1
1.000E0
 2 156
43 ATACCTC,MIR-202:MSigDB ATACCTC,MIR-202:MSigDB MSigDB 1.724E-3 3.062E-2
2.239E-1
1.000E0
 2 170
44 hsa-miR-146b-5p:PITA hsa-miR-146b-5p:PITA TOP PITA 1.744E-3 3.062E-2
2.239E-1
1.000E0
 2 171
45 hsa-miR-146a:PITA hsa-miR-146a:PITA TOP PITA 1.744E-3 3.062E-2
2.239E-1
1.000E0
 2 171
46 hsa-miR-4770:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.764E-3 3.062E-2
2.239E-1
1.000E0
 2 172
47 hsa-miR-219-5p:PITA hsa-miR-219-5p:PITA TOP PITA 1.764E-3 3.062E-2
2.239E-1
1.000E0
 2 172
48 hsa-miR-6088:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.764E-3 3.062E-2
2.239E-1
1.000E0
 2 172
49 hsa-miR-640:PITA hsa-miR-640:PITA TOP PITA 1.784E-3 3.062E-2
2.239E-1
1.000E0
 2 173
50 hsa-miR-1257:PITA hsa-miR-1257:PITA TOP PITA 1.950E-3 3.188E-2
2.331E-1
1.000E0
 2 181
Show 45 more annotations

17: Drug [Display Chart] 26 input genes in category / 4632 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000077802 3-chlorobenzylamine Stitch 6.826E-14 3.162E-10 2.851E-9 3.162E-10 8 91
2 CID000444570 AC1L9GJJ Stitch 4.371E-12 1.012E-8 9.128E-8 2.024E-8 6 40
3 CID000000478 AC1N9TEG Stitch 4.773E-9 7.370E-6 6.646E-5 2.211E-5 6 124
4 5417 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.439E-6 1.410E-3 1.272E-2 6.667E-3 5 175
5 4821 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.522E-6 1.410E-3 1.272E-2 7.051E-3 5 177
6 3710 UP Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.640E-6 2.038E-3 1.838E-2 1.223E-2 5 198
7 CID000164073 Pkcs Stitch 3.603E-6 2.384E-3 2.150E-2 1.669E-2 5 211
8 5580 UP SAHA; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.078E-5 7.784E-3
7.020E-2
1.889E-1
 4 172
9 1659 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.172E-5 7.784E-3
7.020E-2
1.932E-1
 4 173
10 5308 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.172E-5 7.784E-3
7.020E-2
1.932E-1
 4 173
11 6085 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.267E-5 7.784E-3
7.020E-2
1.976E-1
 4 174
12 2777 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.363E-5 7.784E-3
7.020E-2
2.021E-1
 4 175
13 5441 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.461E-5 7.784E-3
7.020E-2
2.066E-1
 4 176
14 6493 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.561E-5 7.784E-3
7.020E-2
2.112E-1
 4 177
15 4768 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.561E-5 7.784E-3
7.020E-2
2.112E-1
 4 177
16 4770 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.561E-5 7.784E-3
7.020E-2
2.112E-1
 4 177
17 3462 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.561E-5 7.784E-3
7.020E-2
2.112E-1
 4 177
18 4388 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.662E-5 7.784E-3
7.020E-2
2.159E-1
 4 178
19 2794 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.765E-5 7.784E-3
7.020E-2
2.207E-1
 4 179
20 6951 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.765E-5 7.784E-3
7.020E-2
2.207E-1
 4 179
21 6579 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.869E-5 7.784E-3
7.020E-2
2.255E-1
 4 180
22 2247 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.869E-5 7.784E-3
7.020E-2
2.255E-1
 4 180
23 5484 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.869E-5 7.784E-3
7.020E-2
2.255E-1
 4 180
24 6939 UP SAHA; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.869E-5 7.784E-3
7.020E-2
2.255E-1
 4 180
25 5987 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 4.975E-5 7.784E-3
7.020E-2
2.305E-1
 4 181
26 5010 UP Prochlorperazine dimaleate [84-02-6]; Up 200; 6.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.083E-5 7.784E-3
7.020E-2
2.355E-1
 4 182
27 7043 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.083E-5 7.784E-3
7.020E-2
2.355E-1
 4 182
28 5511 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.083E-5 7.784E-3
7.020E-2
2.355E-1
 4 182
29 5017 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.083E-5 7.784E-3
7.020E-2
2.355E-1
 4 182
30 6434 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.193E-5 7.784E-3
7.020E-2
2.405E-1
 4 183
31 CID000002940 D 609 Stitch 5.209E-5 7.784E-3
7.020E-2
2.413E-1
 3 64
32 7499 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.532E-5 7.929E-3
7.150E-2
2.562E-1
 4 186
33 5976 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 5.649E-5 7.929E-3
7.150E-2
2.616E-1
 4 187
34 CID000003501 Go6976 Stitch 6.009E-5 8.187E-3
7.383E-2
2.783E-1
 4 190
35 6740 UP Cyproheptadine hydrochloride [969-33-5]; Up 200; 12.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.780E-5 8.376E-3
7.554E-2
3.141E-1
 4 196
36 2706 UP Vidarabine [5536-17-4]; Up 200; 15uM; HL60; HT HG-U133A Broad Institute CMAP Up 6.780E-5 8.376E-3
7.554E-2
3.141E-1
 4 196
37 7371 UP Clemizole hydrochloride [1163-36-6]; Up 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.780E-5 8.376E-3
7.554E-2
3.141E-1
 4 196
38 6708 UP Flupentixol dihydrochloride cis-(Z) [2413-38-9]; Up 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 6.915E-5 8.376E-3
7.554E-2
3.203E-1
 4 197
39 1919 DN Tolnaftate [2398-96-1]; Down 200; 13uM; PC3; HG-U133A Broad Institute CMAP Down 7.052E-5 8.376E-3
7.554E-2
3.267E-1
 4 198
40 CID000004597 o-nitrophenyl beta-D-fucopyranoside Stitch 8.373E-5 9.696E-3
8.744E-2
3.878E-1
 3 75
41 CID000004407 2,3-Dichloro-5,8-dihydroxy-1,4-naphthoquinone Stitch 1.677E-4 1.894E-2
1.708E-1
7.767E-1
 2 17
42 CID000024599 strontium chromate Stitch 1.910E-4 2.106E-2
1.900E-1
8.847E-1
 3 99
43 CID000028683 4 alpha-phorbol Stitch 2.147E-4 2.313E-2
2.086E-1
9.945E-1
 3 103
44 CID000114822 AC1L3G0K Stitch 5.315E-4 3.814E-2
3.440E-1
1.000E0
 2 30
45 CID000214797 Ro 31 Stitch 5.395E-4 3.814E-2
3.440E-1
1.000E0
 3 141
46 CID003274883 AC1MNA05 Stitch 5.677E-4 3.814E-2
3.440E-1
1.000E0
 2 31
47 CID000445141 AC1L9HHR Stitch 6.475E-4 3.814E-2
3.440E-1
1.000E0
 4 354
48 ctd:D002713 Chlorine CTD 7.486E-4 3.814E-2
3.440E-1
1.000E0
 4 368
49 ctd:C540355 1-anilino-4-methyl-2-methylthio-4-phenylimidazolin-5-one CTD 7.872E-4 3.814E-2
3.440E-1
1.000E0
 4 373
50 CID005281656 norathyriol Stitch 8.097E-4 3.814E-2
3.440E-1
1.000E0
 2 37
Show 45 more annotations

18: Disease [Display Chart] 25 input genes in category / 323 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C2062763 Benzodiazepine abuse DisGeNET BeFree 2.285E-6 7.380E-4 4.691E-3 7.380E-4 2 2
2 C4076671 Prostate cancer metastatic to bone DisGeNET BeFree 6.848E-6 1.106E-3 7.030E-3 2.212E-3 2 3
3 cv:CN181757 Parkinson disease 19, juvenile-onset Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
4 OMIN:608194 CONE-ROD DYSTROPHY 13; CORD13 OMIM 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
5 C4015038 MYASTHENIC SYNDROME, CONGENITAL, 7, PRESYNAPTIC DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
6 C2750720 Cone-Rod Dystrophy 13 DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
7 cv:CN219804 Myasthenic syndrome, presynaptic, congenital, with or without motor neuropathy Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
8 C1854260 LEBER CONGENITAL AMAUROSIS 6 (disorder) DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
9 cv:C2750720 Cone-rod dystrophy 13 Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
10 C1854372 Decreased vibration sense at ankles DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
11 cv:C3280914 Familial cold autoinflammatory syndrome 3 Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
12 C1854369 Spinocerebellar ataxia 14 DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
13 C3280914 FAMILIAL COLD AUTOINFLAMMATORY SYNDROME 3 DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
14 cv:CN158804 Autoinflammation, antibody deficiency, and immune dysregulation, plcg2-associated Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
15 C3553961 AUTOINFLAMMATION, ANTIBODY DEFICIENCY, AND IMMUNE DYSREGULATION, PLCG2-ASSOCIATED DisGeNET Curated 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
16 OMIN:605361 SPINOCEREBELLAR ATAXIA 14; SCA14 OMIM 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
17 cv:C1854260 Leber congenital amaurosis 6 Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
18 cv:C1854369 Spinocerebellar ataxia 14 Clinical Variations 1.543E-3 2.768E-2
1.760E-1
4.983E-1
 1 1
Show 13 more annotations