|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
12805222
|
Regulation of the Wnt signaling pathway by disabled-2 (Dab2).
|
Pubmed
|
4.973E-14
|
5.436E-11
|
4.117E-10
|
5.436E-11
|
4
|
9
|
2
|
10644691
|
Protein phosphatase 2Calpha dephosphorylates axin and activates LEF-1-dependent transcription.
|
Pubmed
|
1.302E-13
|
7.117E-11
|
5.391E-10
|
1.423E-10
|
4
|
11
|
3
|
24431302
|
Wnt signaling in midbrain dopaminergic neuron development and regenerative medicine for Parkinson's disease.
|
Pubmed
|
2.359E-13
|
8.594E-11
|
6.509E-10
|
2.578E-10
|
5
|
64
|
4
|
19515997
|
Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation.
|
Pubmed
|
1.142E-12
|
3.120E-10
|
2.364E-9
|
1.248E-9
|
5
|
87
|
5
|
18093802
|
Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
6
|
27744318
|
Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
7
|
18162551
|
Mechanism of activation of the Formin protein Daam1.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
8
|
25043421
|
Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
9
|
27086035
|
Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
10
|
8973355
|
Genomic organization of mouse Dishevelled genes.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
11
|
18692936
|
Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
12
|
21092292
|
Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
13
|
23437169
|
Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.
|
Pubmed
|
3.770E-12
|
3.169E-10
|
2.401E-9
|
4.120E-9
|
3
|
3
|
14
|
24852369
|
Atmin mediates kidney morphogenesis by modulating Wnt signaling.
|
Pubmed
|
4.190E-12
|
3.271E-10
|
2.478E-9
|
4.580E-9
|
4
|
24
|
15
|
24643799
|
Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
16
|
27599467
|
The expression of SFRP1, SFRP3, DVL1, and DVL2 proteins in testicular germ cell tumors.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
17
|
9192851
|
Human dishevelled genes constitute a DHR-containing multigene family.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
18
|
23371553
|
Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
19
|
11113207
|
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
20
|
19465938
|
Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
21
|
8817329
|
cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
22
|
25557784
|
DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
23
|
17593335
|
Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
24
|
19625296
|
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
25
|
18772438
|
Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.
|
Pubmed
|
1.508E-11
|
6.592E-10
|
4.993E-9
|
1.648E-8
|
3
|
4
|
26
|
11779461
|
Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1.
|
Pubmed
|
3.769E-11
|
1.373E-9
|
1.040E-8
|
4.120E-8
|
3
|
5
|
27
|
15456783
|
Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.
|
Pubmed
|
3.769E-11
|
1.373E-9
|
1.040E-8
|
4.120E-8
|
3
|
5
|
28
|
25424568
|
A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.
|
Pubmed
|
3.769E-11
|
1.373E-9
|
1.040E-8
|
4.120E-8
|
3
|
5
|
29
|
24469800
|
CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.
|
Pubmed
|
3.769E-11
|
1.373E-9
|
1.040E-8
|
4.120E-8
|
3
|
5
|
30
|
22826439
|
The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.
|
Pubmed
|
3.769E-11
|
1.373E-9
|
1.040E-8
|
4.120E-8
|
3
|
5
|
31
|
18351675
|
Members of the WNT signaling pathways are widely expressed in mouse ovaries, oocytes, and cleavage stage embryos.
|
Pubmed
|
7.023E-11
|
2.423E-9
|
1.835E-8
|
7.677E-8
|
4
|
47
|
32
|
19008950
|
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development.
|
Pubmed
|
7.538E-11
|
2.423E-9
|
1.835E-8
|
8.239E-8
|
3
|
6
|
33
|
20439735
|
SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.
|
Pubmed
|
7.538E-11
|
2.423E-9
|
1.835E-8
|
8.239E-8
|
3
|
6
|
34
|
21880741
|
Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.
|
Pubmed
|
7.538E-11
|
2.423E-9
|
1.835E-8
|
8.239E-8
|
3
|
6
|
35
|
17005174
|
Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.
|
Pubmed
|
1.319E-10
|
3.604E-9
|
2.730E-8
|
1.442E-7
|
3
|
7
|
36
|
10330403
|
Domains of axin involved in protein-protein interactions, Wnt pathway inhibition, and intracellular localization.
|
Pubmed
|
1.319E-10
|
3.604E-9
|
2.730E-8
|
1.442E-7
|
3
|
7
|
37
|
10806215
|
Endogenous protein kinase CK2 participates in Wnt signaling in mammary epithelial cells.
|
Pubmed
|
1.319E-10
|
3.604E-9
|
2.730E-8
|
1.442E-7
|
3
|
7
|
38
|
15262978
|
The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
|
Pubmed
|
1.319E-10
|
3.604E-9
|
2.730E-8
|
1.442E-7
|
3
|
7
|
39
|
12165471
|
Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1.
|
Pubmed
|
1.319E-10
|
3.604E-9
|
2.730E-8
|
1.442E-7
|
3
|
7
|
40
|
22773187
|
Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning.
|
Pubmed
|
1.319E-10
|
3.604E-9
|
2.730E-8
|
1.442E-7
|
3
|
7
|
41
|
19388021
|
Sequence requirement and subtype specificity in the high-affinity interaction between human frizzled and dishevelled proteins.
|
Pubmed
|
2.110E-10
|
5.625E-9
|
4.261E-8
|
2.306E-7
|
3
|
8
|
42
|
22899650
|
LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.
|
Pubmed
|
3.165E-10
|
8.045E-9
|
6.094E-8
|
3.459E-7
|
3
|
9
|
43
|
16487141
|
Expression of planar cell polarity genes during development of the mouse CNS.
|
Pubmed
|
3.165E-10
|
8.045E-9
|
6.094E-8
|
3.459E-7
|
3
|
9
|
44
|
15637299
|
Vangl2 acts via RhoA signaling to regulate polarized cell movements during development of the proximal outflow tract.
|
Pubmed
|
4.521E-10
|
1.123E-8
|
8.507E-8
|
4.942E-7
|
3
|
10
|
45
|
12433684
|
Identification of 2 novel genes developmentally regulated in the mouse aorta-gonad-mesonephros region.
|
Pubmed
|
8.287E-10
|
1.927E-8
|
1.460E-7
|
9.058E-7
|
3
|
12
|
46
|
23122850
|
Microtubules enable the planar cell polarity of airway cilia.
|
Pubmed
|
8.287E-10
|
1.927E-8
|
1.460E-7
|
9.058E-7
|
3
|
12
|
47
|
12421720
|
Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.
|
Pubmed
|
8.287E-10
|
1.927E-8
|
1.460E-7
|
9.058E-7
|
3
|
12
|
48
|
20412773
|
The Hippo pathway regulates Wnt/beta-catenin signaling.
|
Pubmed
|
1.077E-9
|
2.453E-8
|
1.858E-7
|
1.177E-6
|
3
|
13
|
49
|
22771245
|
The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled.
|
Pubmed
|
1.714E-9
|
3.822E-8
|
2.895E-7
|
1.873E-6
|
3
|
15
|
50
|
20970343
|
Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein.
|
Pubmed
|
2.561E-9
|
5.597E-8
|
4.240E-7
|
2.799E-6
|
3
|
17
|