|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
17332529
|
Duox expression and related H2O2 measurement in mouse thyroid: onset in embryonic development and regulation by TSH in adult.
|
Pubmed
|
2.233E-18
|
7.277E-15
|
6.307E-14
|
7.277E-15
|
5
|
6
|
2
|
12432093
|
Role of the thyroid-stimulating hormone receptor signaling in development and differentiation of the thyroid gland.
|
Pubmed
|
1.657E-13
|
2.701E-10
|
2.341E-9
|
5.402E-10
|
4
|
8
|
3
|
22132122
|
The microRNA-processing enzyme Dicer is essential for thyroid function.
|
Pubmed
|
1.171E-12
|
1.273E-9
|
1.103E-8
|
3.818E-9
|
4
|
12
|
4
|
25127920
|
The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells.
|
Pubmed
|
1.692E-12
|
1.378E-9
|
1.195E-8
|
5.514E-9
|
4
|
13
|
5
|
24265449
|
The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.
|
Pubmed
|
9.165E-12
|
5.764E-9
|
4.995E-8
|
2.987E-8
|
4
|
19
|
6
|
16260629
|
Pendrin is a novel in vivo downstream target gene of the TTF-1/Nkx-2.1 homeodomain transcription factor in differentiated thyroid cells.
|
Pubmed
|
1.292E-11
|
5.764E-9
|
4.995E-8
|
4.212E-8
|
3
|
3
|
7
|
28396984
|
Iodinated TG in Thyroid Follicles Regulate TSH/TSHR Signaling for NIS Expression.
|
Pubmed
|
1.292E-11
|
5.764E-9
|
4.995E-8
|
4.212E-8
|
3
|
3
|
8
|
23707896
|
Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation.
|
Pubmed
|
1.415E-11
|
5.764E-9
|
4.995E-8
|
4.611E-8
|
4
|
21
|
9
|
15231702
|
Minireview: thyrotropin receptor signaling in development and differentiation of the thyroid gland: insights from mouse models and human diseases.
|
Pubmed
|
5.169E-11
|
1.685E-8
|
1.460E-7
|
1.685E-7
|
3
|
4
|
10
|
28322461
|
Iodinated TG in Thyroid Follicular Lumen Regulates TTF-1 and PAX8 Expression via TSH/TSHR Signaling Pathway.
|
Pubmed
|
5.169E-11
|
1.685E-8
|
1.460E-7
|
1.685E-7
|
3
|
4
|
11
|
20578903
|
Initial characterization of C16orf89, a novel thyroid-specific gene.
|
Pubmed
|
1.292E-10
|
3.828E-8
|
3.318E-7
|
4.211E-7
|
3
|
5
|
12
|
17854396
|
Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake.
|
Pubmed
|
2.584E-10
|
6.477E-8
|
5.614E-7
|
8.421E-7
|
3
|
6
|
13
|
16150900
|
A mouse model demonstrates a multigenic origin of congenital hypothyroidism.
|
Pubmed
|
2.584E-10
|
6.477E-8
|
5.614E-7
|
8.421E-7
|
3
|
6
|
14
|
12815622
|
Perturbed thyroid morphology and transient hypothyroidism symptoms in Hoxa5 mutant mice.
|
Pubmed
|
1.085E-9
|
2.525E-7
|
2.188E-6
|
3.535E-6
|
3
|
9
|
15
|
21364918
|
Hes1 is required for appropriate morphogenesis and differentiation during mouse thyroid gland development.
|
Pubmed
|
1.549E-9
|
3.156E-7
|
2.735E-6
|
5.050E-6
|
3
|
10
|
16
|
21345181
|
In vivo role of different domains and of phosphorylation in the transcription factor Nkx2-1.
|
Pubmed
|
1.549E-9
|
3.156E-7
|
2.735E-6
|
5.050E-6
|
3
|
10
|
17
|
12036966
|
Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.
|
Pubmed
|
2.154E-9
|
4.130E-7
|
3.579E-6
|
7.020E-6
|
4
|
70
|
18
|
19730683
|
The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
|
Pubmed
|
8.812E-9
|
1.595E-6
|
1.383E-5
|
2.872E-5
|
4
|
99
|
19
|
23563309
|
Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.
|
Pubmed
|
2.964E-8
|
4.904E-6
|
4.250E-5
|
9.659E-5
|
3
|
25
|
20
|
2293030
|
Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
21
|
29587766
|
ADRB3 polymorphism rs4994 (Trp64Arg) associates significantly with bodyweight elevation and dyslipidaemias in Saudis but not rs1801253 (Arg389Gly) polymorphism in ARDB1.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
22
|
21989446
|
Expression and correlation of sodium/iodide symporter and thyroid stimulating hormone receptor in human thyroid carcinoma.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
23
|
14633662
|
Risk of non-medullary thyroid cancer influenced by polymorphic variation in the thyroglobulin gene.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
24
|
23174149
|
Iodide transporters expression in early human invasive trophoblast.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
25
|
1651314
|
Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
26
|
2249482
|
Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
27
|
28743746
|
De novo triiodothyronine formation from thyrocytes activated by thyroid-stimulating hormone.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
28
|
19196800
|
Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
29
|
22781452
|
[Influences of nevirapine on cell proliferation and expression of sodium/iodide symporter in human anaplastic thyroid carcinoma cell line].
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
30
|
18162522
|
An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
31
|
16631628
|
Functional beta-adrenergic receptor signalling on nuclear membranes in adult rat and mouse ventricular cardiomyocytes.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
32
|
12907760
|
Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
33
|
18379122
|
Thyrotropin receptor and thyroid transcription factor-1 genes variant in Chinese children with congenital hypothyroidism.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
34
|
17938324
|
Methylation status of genes in papillary thyroid carcinoma.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
35
|
29092890
|
Association between monoallelic TSHR mutations and congenital hypothyroidism: a statistical approach.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
36
|
22309849
|
Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
37
|
24353283
|
Different expression of TSH receptor and NIS genes in thyroid cancer: role of epigenetics.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
38
|
24972470
|
Association of β1 and β3 adrenergic receptors gene polymorphisms with insulin resistance and high lipid profiles related to type 2 diabetes and metabolic syndrome.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
39
|
22306453
|
Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
40
|
11312274
|
A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
41
|
22517745
|
Human fibrocytes coexpress thyroglobulin and thyrotropin receptor.
|
Pubmed
|
6.170E-8
|
4.904E-6
|
4.250E-5
|
2.011E-4
|
2
|
2
|
42
|
18240029
|
Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.
|
Pubmed
|
1.495E-7
|
6.777E-6
|
5.873E-5
|
4.872E-4
|
4
|
200
|
43
|
9697704
|
A mouse model for hereditary thyroid dysgenesis and cleft palate.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
44
|
12387862
|
Beta(1)/beta(2)/beta(3)-adrenoceptor knockout mice are obese and cold-sensitive but have normal lipolytic responses to fasting.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
45
|
15474034
|
Control of 4E-BP1 expression in mouse brown adipose tissue by the beta3-adrenoceptor.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
46
|
24885710
|
Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
47
|
18239290
|
Adrenergic beta1 receptor polymorphism (Ser49Gly) is associated with obesity in type II diabetic patients.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
48
|
12709678
|
Relationship of clinical features and laboratory parameters to thyroid echogenicity measured by standardized grey scale ultrasonography in patients with Hashimoto's thyroiditis.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
49
|
18311486
|
Expression and functional role of beta-adrenoceptors in the human urinary bladder urothelium.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|
50
|
19420258
|
Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity.
|
Pubmed
|
1.851E-7
|
6.777E-6
|
5.873E-5
|
6.032E-4
|
2
|
3
|