Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc137_9, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 75 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0003990 acetylcholinesterase activity 2.068E-7 1.551E-5 7.601E-5 1.551E-5 2 2
2 GO:0004104 cholinesterase activity 6.202E-7 2.326E-5 1.140E-4 4.651E-5 2 3
3 GO:0033265 choline binding 4.337E-6 1.084E-4 5.314E-4 3.253E-4 2 7
4 GO:0052689 carboxylic ester hydrolase activity 5.288E-5 2.459E-4 1.205E-3 3.966E-3 3 163
5 GO:0018734 butyrolactone hydrolase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
6 GO:0043906 Ala-tRNA(Pro) hydrolase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
7 GO:0018731 1-oxa-2-oxocycloheptane lactonase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
8 GO:0080031 methyl salicylate esterase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
9 GO:0047376 all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
10 GO:0035460 L-ascorbate 6-phosphate lactonase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
11 GO:0034892 endosulfan lactone lactonase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
12 GO:0043907 Cys-tRNA(Pro) hydrolase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
13 GO:0010296 prenylcysteine methylesterase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
14 GO:0043905 Ser-tRNA(Thr) hydrolase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
15 GO:0043908 Ser(Gly)-tRNA(Ala) hydrolase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
16 GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
17 GO:0052768 mannosyl-oligosaccharide 1,3-alpha-mannosidase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
18 GO:0080032 methyl jasmonate esterase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
19 GO:0018732 sulfolactone hydrolase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
20 GO:0080030 methyl indole-3-acetate esterase activity 6.680E-5 2.459E-4 1.205E-3 5.010E-3 2 26
21 GO:0018733 3,4-dihydrocoumarin hydrolase activity 7.212E-5 2.459E-4 1.205E-3 5.409E-3 2 27
22 GO:0051723 protein methylesterase activity 7.212E-5 2.459E-4 1.205E-3 5.409E-3 2 27
23 GO:0050253 retinyl-palmitate esterase activity 7.765E-5 2.532E-4 1.241E-3 5.824E-3 2 28
24 GO:0001540 amyloid-beta binding 1.292E-4 4.036E-4 1.978E-3 9.687E-3 2 36
25 GO:0002161 aminoacyl-tRNA editing activity 1.365E-4 4.095E-4 2.007E-3 1.024E-2 2 37
26 GO:0015924 mannosyl-oligosaccharide mannosidase activity 2.503E-4 7.219E-4 3.538E-3 1.877E-2 2 50
27 GO:0004559 alpha-mannosidase activity 2.604E-4 7.234E-4 3.546E-3 1.953E-2 2 51
28 GO:0015923 mannosidase activity 2.708E-4 7.253E-4 3.555E-3 2.031E-2 2 52
29 GO:0050997 quaternary ammonium group binding 2.921E-4 7.553E-4 3.702E-3 2.190E-2 2 54
30 GO:0070405 ammonium ion binding 6.249E-4 1.562E-3 7.657E-3 4.687E-2 2 79
31 GO:0030550 acetylcholine receptor inhibitor activity 9.644E-4 2.260E-3 1.108E-2
7.233E-2
 1 2
32 GO:0004063 aryldialkylphosphatase activity 9.644E-4 2.260E-3 1.108E-2
7.233E-2
 1 2
33 GO:0043178 alcohol binding 1.250E-3 2.842E-3 1.393E-2
9.378E-2
 2 112
34 GO:0046573 lactonohydrolase activity 1.446E-3 3.099E-3 1.519E-2
1.085E-1
 1 3
35 GO:0102007 acyl-L-homoserine-lactone lactonohydrolase activity 1.446E-3 3.099E-3 1.519E-2
1.085E-1
 1 3
36 GO:0004620 phospholipase activity 1.529E-3 3.186E-3 1.562E-2
1.147E-1
 2 124
37 GO:0016298 lipase activity 1.889E-3 3.829E-3 1.877E-2
1.417E-1
 2 138
38 GO:0099602 neurotransmitter receptor regulator activity 2.409E-3 4.518E-3 2.214E-2
1.807E-1
 1 5
39 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity 2.409E-3 4.518E-3 2.214E-2
1.807E-1
 1 5
40 GO:0030548 acetylcholine receptor regulator activity 2.409E-3 4.518E-3 2.214E-2
1.807E-1
 1 5
41 GO:0004064 arylesterase activity 2.891E-3 5.288E-3 2.592E-2
2.168E-1
 1 6
42 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds 3.256E-3 5.814E-3 2.849E-2
2.442E-1
 2 182
43 GO:0016798 hydrolase activity, acting on glycosyl bonds 4.188E-3 7.305E-3 3.580E-2
3.141E-1
 2 207
44 GO:0008035 high-density lipoprotein particle binding 4.333E-3 7.386E-3 3.620E-2
3.250E-1
 1 9
45 GO:0030547 receptor inhibitor activity 6.733E-3 1.122E-2
5.500E-2
5.050E-1
 1 14
46 GO:0042277 peptide binding 7.430E-3 1.211E-2
5.937E-2
5.572E-1
 2 278
47 GO:0033218 amide binding 9.111E-3 1.454E-2
7.126E-2
6.833E-1
 2 309
48 GO:0001848 complement binding 1.008E-2 1.576E-2
7.723E-2
7.564E-1
 1 21
49 GO:0043395 heparan sulfate proteoglycan binding 1.104E-2 1.690E-2
8.283E-2
8.280E-1
 1 23
50 GO:0042166 acetylcholine binding 1.200E-2 1.799E-2
8.817E-2
8.997E-1
 1 25
Show 45 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 237 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0019695 choline metabolic process 9.324E-6 7.829E-4 4.734E-3 2.210E-3 2 10
2 GO:0006650 glycerophospholipid metabolic process 9.346E-6 7.829E-4 4.734E-3 2.215E-3 4 314
3 GO:0042439 ethanolamine-containing compound metabolic process 9.910E-6 7.829E-4 4.734E-3 2.349E-3 3 93
4 GO:0046486 glycerolipid metabolic process 2.597E-5 1.120E-3 6.772E-3 6.154E-3 4 407
5 GO:0006576 cellular biogenic amine metabolic process 2.708E-5 1.120E-3 6.772E-3 6.417E-3 3 130
6 GO:0006644 phospholipid metabolic process 3.077E-5 1.120E-3 6.772E-3 7.293E-3 4 425
7 GO:0042157 lipoprotein metabolic process 3.308E-5 1.120E-3 6.772E-3 7.839E-3 3 139
8 GO:0097164 ammonium ion metabolic process 8.133E-5 2.300E-3 1.391E-2 1.927E-2 3 188
9 GO:0006506 GPI anchor biosynthetic process 1.088E-4 2.300E-3 1.391E-2 2.578E-2 2 33
10 GO:0044106 cellular amine metabolic process 1.114E-4 2.300E-3 1.391E-2 2.639E-2 3 209
11 GO:0046474 glycerophospholipid biosynthetic process 1.129E-4 2.300E-3 1.391E-2 2.677E-2 3 210
12 GO:0006505 GPI anchor metabolic process 1.225E-4 2.300E-3 1.391E-2 2.904E-2 2 35
13 GO:0009308 amine metabolic process 1.262E-4 2.300E-3 1.391E-2 2.990E-2 3 218
14 GO:0045017 glycerolipid biosynthetic process 1.697E-4 2.873E-3 1.738E-2 4.023E-2 3 241
15 GO:0008654 phospholipid biosynthetic process 1.936E-4 3.059E-3 1.850E-2 4.589E-2 3 252
16 GO:0007271 synaptic transmission, cholinergic 2.615E-4 3.873E-3 2.342E-2
6.197E-2
 2 51
17 GO:0009247 glycolipid biosynthetic process 4.251E-4 5.563E-3 3.364E-2
1.007E-1
 2 65
18 GO:0046448 tropane alkaloid metabolic process 4.833E-4 5.563E-3 3.364E-2
1.145E-1
 1 1
19 GO:0001971 negative regulation of activation of membrane attack complex 4.833E-4 5.563E-3 3.364E-2
1.145E-1
 1 1
20 GO:0050783 cocaine metabolic process 4.833E-4 5.563E-3 3.364E-2
1.145E-1
 1 1
21 GO:0046470 phosphatidylcholine metabolic process 4.929E-4 5.563E-3 3.364E-2
1.168E-1
 2 70
22 GO:0050805 negative regulation of synaptic transmission 5.808E-4 6.257E-3 3.784E-2
1.377E-1
 2 76
23 GO:0006497 protein lipidation 6.923E-4 7.134E-3 4.314E-2
1.641E-1
 2 83
24 GO:0006066 alcohol metabolic process 7.948E-4 7.848E-3 4.746E-2
1.884E-1
 3 408
25 GO:0042158 lipoprotein biosynthetic process 8.314E-4 7.882E-3 4.766E-2
1.970E-1
 2 91
26 GO:0006581 acetylcholine catabolic process 9.663E-4 7.897E-3 4.776E-2
2.290E-1
 1 2
27 GO:0001507 acetylcholine catabolic process in synaptic cleft 9.663E-4 7.897E-3 4.776E-2
2.290E-1
 1 2
28 GO:0032223 negative regulation of synaptic transmission, cholinergic 9.663E-4 7.897E-3 4.776E-2
2.290E-1
 1 2
29 GO:0045212 neurotransmitter receptor biosynthetic process 9.663E-4 7.897E-3 4.776E-2
2.290E-1
 1 2
30 GO:0006664 glycolipid metabolic process 1.392E-3 9.631E-3
5.824E-2
3.299E-1
 2 118
31 GO:0034445 negative regulation of plasma lipoprotein oxidation 1.449E-3 9.631E-3
5.824E-2
3.435E-1
 1 3
32 GO:0014016 neuroblast differentiation 1.449E-3 9.631E-3
5.824E-2
3.435E-1
 1 3
33 GO:0034444 regulation of plasma lipoprotein oxidation 1.449E-3 9.631E-3
5.824E-2
3.435E-1
 1 3
34 GO:0001905 activation of membrane attack complex 1.449E-3 9.631E-3
5.824E-2
3.435E-1
 1 3
35 GO:0001969 regulation of activation of membrane attack complex 1.449E-3 9.631E-3
5.824E-2
3.435E-1
 1 3
36 GO:1903509 liposaccharide metabolic process 1.463E-3 9.631E-3
5.824E-2
3.467E-1
 2 121
37 GO:0006661 phosphatidylinositol biosynthetic process 1.610E-3 1.031E-2
6.236E-2
3.815E-1
 2 127
38 GO:0046467 membrane lipid biosynthetic process 1.686E-3 1.051E-2
6.358E-2
3.995E-1
 2 130
39 GO:1902617 response to fluoride 1.932E-3 1.117E-2
6.753E-2
4.578E-1
 1 4
40 GO:0034443 negative regulation of lipoprotein oxidation 1.932E-3 1.117E-2
6.753E-2
4.578E-1
 1 4
41 GO:0034441 plasma lipoprotein particle oxidation 1.932E-3 1.117E-2
6.753E-2
4.578E-1
 1 4
42 GO:0045918 negative regulation of cytolysis 2.414E-3 1.331E-2
8.047E-2
5.722E-1
 1 5
43 GO:0034442 regulation of lipoprotein oxidation 2.414E-3 1.331E-2
8.047E-2
5.722E-1
 1 5
44 GO:0045213 neurotransmitter receptor metabolic process 2.897E-3 1.492E-2
9.025E-2
6.865E-1
 1 6
45 GO:0042161 lipoprotein oxidation 2.897E-3 1.492E-2
9.025E-2
6.865E-1
 1 6
46 GO:0042160 lipoprotein modification 2.897E-3 1.492E-2
9.025E-2
6.865E-1
 1 6
47 GO:1900619 acetate ester metabolic process 3.379E-3 1.601E-2
9.684E-2
8.007E-1
 1 7
48 GO:0008291 acetylcholine metabolic process 3.379E-3 1.601E-2
9.684E-2
8.007E-1
 1 7
49 GO:0050748 negative regulation of lipoprotein metabolic process 3.379E-3 1.601E-2
9.684E-2
8.007E-1
 1 7
50 GO:0016255 attachment of GPI anchor to protein 3.379E-3 1.601E-2
9.684E-2
8.007E-1
 1 7
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 50 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031225 anchored component of membrane 4.800E-9 2.400E-7 1.080E-6 2.400E-7 5 160
2 GO:0031012 extracellular matrix 9.498E-4 2.374E-2
1.068E-1
 4.749E-2 3 444
3 GO:0072562 blood microparticle 1.944E-3 2.870E-2
1.291E-1
9.719E-2
 2 143
4 GO:0042765 GPI-anchor transamidase complex 2.359E-3 2.870E-2
1.291E-1
1.179E-1
 1 5
5 GO:0034366 spherical high-density lipoprotein particle 3.772E-3 2.870E-2
1.291E-1
1.886E-1
 1 8
6 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex 3.772E-3 2.870E-2
1.291E-1
1.886E-1
 1 8
7 GO:0005788 endoplasmic reticulum lumen 4.018E-3 2.870E-2
1.291E-1
2.009E-1
 2 207
8 GO:0043083 synaptic cleft 4.713E-3 2.945E-2
1.325E-1
2.356E-1
 1 10
9 GO:0005641 nuclear envelope lumen 5.653E-3 3.141E-2
1.413E-1
2.826E-1
 1 12
10 GO:0043218 compact myelin 8.937E-3 4.469E-2
2.011E-1
4.469E-1
 1 19
11 GO:0031362 anchored component of external side of plasma membrane 1.081E-2 4.914E-2
2.211E-1
5.405E-1
 1 23
Show 6 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 392 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004818 Paroxysmal nocturnal hemoglobinuria 1.745E-5 3.791E-3 2.483E-2 6.842E-3 3 58
2 HP:0003641 Hemoglobinuria 1.934E-5 3.791E-3 2.483E-2 7.583E-3 3 60

5: Mouse Phenotype [Display Chart] 9 input genes in category / 184 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008873 increased physiological sensitivity to xenobiotic 6.348E-5 1.168E-2
6.768E-2
 1.168E-2 4 285

6: Domain [Display Chart] 9 input genes in category / 55 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR014788 AChE tetra InterPro 2.051E-7 2.821E-6 1.296E-5 1.128E-5 2 2
2 IPR000997 Cholinesterase InterPro 2.051E-7 2.821E-6 1.296E-5 1.128E-5 2 2
3 PF08674 AChE tetra Pfam 2.051E-7 2.821E-6 1.296E-5 1.128E-5 2 2
4 PD415333 AChE tetra ProDom 2.051E-7 2.821E-6 1.296E-5 1.128E-5 2 2
5 PS00122 CARBOXYLESTERASE B 1 PROSITE 5.735E-6 5.257E-5 2.415E-4 3.154E-4 2 8
6 IPR019826 Carboxylesterase B AS InterPro 5.735E-6 5.257E-5 2.415E-4 3.154E-4 2 8
7 IPR019819 Carboxylesterase B CS InterPro 1.596E-5 1.024E-4 4.702E-4 8.776E-4 2 13
8 IPR002018 CarbesteraseB InterPro 1.861E-5 1.024E-4 4.702E-4 1.024E-3 2 14
9 PF00135 COesterase Pfam 1.861E-5 1.024E-4 4.702E-4 1.024E-3 2 14
10 PS00941 CARBOXYLESTERASE B 2 PROSITE 1.861E-5 1.024E-4 4.702E-4 1.024E-3 2 14
11 SM00134 LU SMART 2.453E-5 1.227E-4 5.634E-4 1.349E-3 2 16
12 PF00021 UPAR LY6 Pfam 3.880E-5 1.778E-4 8.169E-4 2.134E-3 2 20
13 PS00983 LY6 UPAR PROSITE 4.715E-5 1.852E-4 8.509E-4 2.593E-3 2 22
14 IPR016054 LY6 UPA recep-like InterPro 4.715E-5 1.852E-4 8.509E-4 2.593E-3 2 22
15 PF04113 Gpi16 Pfam 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
16 IPR031181 Glypican-2 InterPro 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
17 IPR013234 PIGA GPI anchor biosynthesis InterPro 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
18 IPR028726 MMP17 InterPro 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
19 PF08288 PIGA Pfam 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
20 IPR008363 Paraoxonase1 InterPro 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
21 IPR007245 PIG-T InterPro 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
22 IPR027101 CD59 glyco InterPro 4.804E-4 1.201E-3 5.517E-3 2.642E-2 1 1
23 IPR029058 AB hydrolase InterPro 1.399E-3 3.047E-3 1.400E-2
7.694E-2
 2 119
24 3.40.50.1820 - Gene3D 1.399E-3 3.047E-3 1.400E-2
7.694E-2
 2 119
25 IPR002640 Arylesterase InterPro 1.441E-3 3.047E-3 1.400E-2
7.923E-2
 1 3
26 PF01731 Arylesterase Pfam 1.441E-3 3.047E-3 1.400E-2
7.923E-2
 1 3
27 PS01207 GLYPICAN PROSITE 2.879E-3 5.108E-3 2.347E-2
1.584E-1
 1 6
28 IPR001863 Glypican InterPro 2.879E-3 5.108E-3 2.347E-2
1.584E-1
 1 6
29 IPR018363 CD59 antigen CS InterPro 2.879E-3 5.108E-3 2.347E-2
1.584E-1
 1 6
30 IPR019803 Glypican CS InterPro 2.879E-3 5.108E-3 2.347E-2
1.584E-1
 1 6
31 PF01153 Glypican Pfam 2.879E-3 5.108E-3 2.347E-2
1.584E-1
 1 6
32 PF00534 Glycos transf 1 Pfam 3.358E-3 5.597E-3 2.571E-2
1.847E-1
 1 7
33 IPR001296 Glyco trans 1 InterPro 3.358E-3 5.597E-3 2.571E-2
1.847E-1
 1 7
34 IPR016293 Pept M10A stromelysin-type InterPro 8.616E-3 1.344E-2
6.174E-2
4.739E-1
 1 18
35 IPR002477 Peptidoglycan-bd-like InterPro 9.569E-3 1.344E-2
6.174E-2
5.263E-1
 1 20
36 PF01471 PG binding 1 Pfam 9.569E-3 1.344E-2
6.174E-2
5.263E-1
 1 20
37 IPR033739 M10A MMP InterPro 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
38 PS51642 HEMOPEXIN 2 PROSITE 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
39 SM00120 HX SMART 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
40 2.110.10.10 - Gene3D 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
41 IPR018487 Hemopexin-like repeat InterPro 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
42 PS00024 HEMOPEXIN PROSITE 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
43 IPR000585 Hemopexin-like dom InterPro 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
44 IPR021190 Pept M10A InterPro 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
45 PF00045 Hemopexin Pfam 1.100E-2 1.344E-2
6.174E-2
6.048E-1
 1 23
46 PF00413 Peptidase M10 Pfam 1.147E-2 1.372E-2
6.301E-2
6.310E-1
 1 24
47 SM00235 ZnMc SMART 1.385E-2 1.587E-2
7.289E-2
7.616E-1
 1 29
48 IPR006026 Peptidase Metallo InterPro 1.385E-2 1.587E-2
7.289E-2
7.616E-1
 1 29
49 2.120.10.30 - Gene3D 1.858E-2 2.086E-2
9.582E-2
1.000E0
 1 39
50 PS00546 CYSTEINE SWITCH PROSITE 1.953E-2 2.148E-2
9.868E-2
1.000E0
 1 41
Show 45 more annotations

7: Pathway [Display Chart] 8 input genes in category / 64 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1268778 Neurotransmitter Clearance In The Synaptic Cleft BioSystems: REACTOME 1.622E-5 1.038E-3 4.924E-3 1.038E-3 2 10
2 1268748 Synthesis, secretion, and deacylation of Ghrelin BioSystems: REACTOME 6.145E-5 1.966E-3 9.328E-3 3.933E-3 2 19
3 82988 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis BioSystems: KEGG 1.076E-4 2.167E-3 1.028E-2 6.886E-3 2 25
4 1270060 Synthesis of PC BioSystems: REACTOME 1.354E-4 2.167E-3 1.028E-2 8.668E-3 2 28
5 P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway PantherDB 4.898E-4 5.626E-3 2.669E-2 3.135E-2 2 53
6 P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PantherDB 5.275E-4 5.626E-3 2.669E-2 3.376E-2 2 55
7 PW:0000408 acetylcholine metabolic Pathway Ontology 1.285E-3 8.549E-3 4.055E-2
8.223E-2
 1 2
8 138035 Glypican 2 network BioSystems: Pathway Interaction Database 1.285E-3 8.549E-3 4.055E-2
8.223E-2
 1 2
9 P00044 Nicotinic acetylcholine receptor signaling pathway PantherDB 1.438E-3 8.549E-3 4.055E-2
9.202E-2
 2 91
10 1268746 Peptide hormone metabolism BioSystems: REACTOME 1.438E-3 8.549E-3 4.055E-2
9.202E-2
 2 91
11 1268710 Post-translational modification: synthesis of GPI-anchored proteins BioSystems: REACTOME 1.469E-3 8.549E-3 4.055E-2
9.404E-2
 2 92
12 138083 Glypican pathway BioSystems: Pathway Interaction Database 1.927E-3 1.028E-2 4.875E-2
1.233E-1
 1 3
13 1270054 Glycerophospholipid biosynthesis BioSystems: REACTOME 2.907E-3 1.431E-2
6.790E-2
1.861E-1
 2 130
14 1268713 Attachment of GPI anchor to uPAR BioSystems: REACTOME 4.490E-3 2.053E-2
9.738E-2
2.874E-1
 1 7
15 413366 GPI-anchor biosynthesis, core oligosaccharide BioSystems: KEGG 5.130E-3 2.189E-2
1.038E-1
3.283E-1
 1 8
16 1270090 Synthesis of 5-eicosatetraenoic acids BioSystems: REACTOME 5.770E-3 2.308E-2
1.095E-1
3.693E-1
 1 9
17 1270053 Phospholipid metabolism BioSystems: REACTOME 7.279E-3 2.551E-2
1.210E-1
4.659E-1
 2 208
18 1269021 Defective EXT1 causes exostoses 1, TRPS2 and CHDS BioSystems: REACTOME 7.687E-3 2.551E-2
1.210E-1
4.920E-1
 1 12
19 1269022 Defective EXT2 causes exostoses 2 BioSystems: REACTOME 7.687E-3 2.551E-2
1.210E-1
4.920E-1
 1 12
20 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 7.972E-3 2.551E-2
1.210E-1
5.102E-1
 2 218
21 1268712 Synthesis of glycosylphosphatidylinositol (GPI) BioSystems: REACTOME 1.024E-2 3.120E-2
1.480E-1
6.552E-1
 1 16
22 1269015 Defective B3GAT3 causes JDSSDHD BioSystems: REACTOME 1.215E-2 3.239E-2
1.537E-1
7.774E-1
 1 19
23 1309217 Defective B3GALT6 causes EDSP2 and SEMDJL1 BioSystems: REACTOME 1.215E-2 3.239E-2
1.537E-1
7.774E-1
 1 19
24 1269014 Defective B4GALT7 causes EDS, progeroid type BioSystems: REACTOME 1.215E-2 3.239E-2
1.537E-1
7.774E-1
 1 19
25 1269983 HS-GAG degradation BioSystems: REACTOME 1.342E-2 3.435E-2
1.630E-1
8.588E-1
 1 21
26 PW:0000015 Alzheimer disease Pathway Ontology 1.532E-2 3.661E-2
1.737E-1
9.806E-1
 1 24
27 SMP00025 Phospholipid Biosynthesis SMPDB 1.596E-2 3.661E-2
1.737E-1
1.000E0
 1 25
28 1269011 Diseases associated with glycosaminoglycan metabolism BioSystems: REACTOME 1.659E-2 3.661E-2
1.737E-1
1.000E0
 1 26
29 1269981 A tetrasaccharide linker sequence is required for GAG synthesis BioSystems: REACTOME 1.659E-2 3.661E-2
1.737E-1
1.000E0
 1 26
30 1269250 Regulation of Complement cascade BioSystems: REACTOME 1.722E-2 3.674E-2
1.743E-1
1.000E0
 1 27
31 MAP00361 gamma Hexachlorocyclohexane degradation MAP00361 gamma Hexachlorocyclohexane degradation GenMAPP 1.849E-2 3.733E-2
1.771E-1
1.000E0
 1 29
32 PW:0000153 glycerolipid metabolic Pathway Ontology 1.912E-2 3.733E-2
1.771E-1
1.000E0
 1 30
33 1269982 HS-GAG biosynthesis BioSystems: REACTOME 1.975E-2 3.733E-2
1.771E-1
1.000E0
 1 31
34 1268763 Neuronal System BioSystems: REACTOME 1.983E-2 3.733E-2
1.771E-1
1.000E0
 2 351
35 1270258 Activation of Matrix Metalloproteinases BioSystems: REACTOME 2.101E-2 3.843E-2
1.823E-1
1.000E0
 1 33
36 1309087 Cargo concentration in the ER BioSystems: REACTOME 2.165E-2 3.848E-2
1.826E-1
1.000E0
 1 34
37 137954 Arf6 trafficking events BioSystems: Pathway Interaction Database 2.793E-2 4.705E-2
2.232E-1
1.000E0
 1 44
38 1269624 Retinoid metabolism and transport BioSystems: REACTOME 2.793E-2 4.705E-2
2.232E-1
1.000E0
 1 44
39 MAP00561 Glycerolipid metabolism MAP00561 Glycerolipid metabolism GenMAPP 2.981E-2 4.892E-2
2.321E-1
1.000E0
 1 47
Show 34 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 2111 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15060281 Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study. Pubmed 9.047E-12 1.910E-8 1.572E-7 1.910E-8 3 3
2 16213467 Butyrylcholinesterase, paraoxonase, and albumin esterase, but not carboxylesterase, are present in human plasma. Pubmed 3.618E-11 3.819E-8 3.144E-7 7.639E-8 3 4
3 20529763 Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. Pubmed 3.661E-8 2.742E-6 2.257E-5 7.729E-5 3 30
4 8651510 Activity of acetylcholinesterase and unspecific cholinesterase during differentiation of somites in mouse embryos. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
5 19019080 Respective roles of the catalytic domains and C-terminal tail peptides in the oligomerization and secretory trafficking of human acetylcholinesterase and butyrylcholinesterase. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
6 17335779 Calcium-activated butyrylcholinesterase in human skin protects acetylcholinesterase against suicide inhibition by neurotoxic organophosphates. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
7 28465191 Activity of cholinesterases in a young and healthy middle-European population: Relevance for toxicology, pharmacology and clinical praxis. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
8 17194517 Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
9 16909200 Cholinesterases are down-expressed in human colorectal carcinoma. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
10 15629887 Acetylcholinesterase/paraoxonase interactions increase the risk of insecticide-induced Parkinson's disease. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
11 24473115 Arylesterase phenotype-specific positive association between arylesterase activity and cholinesterase specific activity in human serum. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
12 15715671 Inherited and acquired interactions between ACHE and PON1 polymorphisms modulate plasma acetylcholinesterase and paraoxonase activities. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
13 21473860 Variation of the butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) genes in coronary artery disease. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
14 20805581 Localization of butyrylcholinesterase at the neuromuscular junction of normal and acetylcholinesterase knockout mice. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
15 18457821 Rational design of a drug for Alzheimer's disease with cholinesterase inhibitory and neuroprotective activity. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
16 23625910 Effect of paraoxonase 1 192 Q/R polymorphism on paraoxonase and acetylcholinesterase enzyme activities in a Turkish population exposed to organophosphate. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
17 23466605 Discovery of novel 2,6-disubstituted pyridazinone derivatives as acetylcholinesterase inhibitors. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
18 20193849 Amplification and deletion of the ACHE and BCHE cholinesterase genes in sporadic breast cancer. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
19 22560633 Cholinesterase activities and biochemical determinations in patients with prostate cancer: influence of Gleason score, treatment and bone metastasis. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
20 2400605 Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
21 17212694 Excessive hippocampal acetylcholine levels in acetylcholinesterase-deficient mice are moderated by butyrylcholinesterase activity. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
22 20356562 Analysis of cholinesterases in human prostate and sperm: implications in cancer and fertility. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
23 12009429 Antidepressants inhibit human acetylcholinesterase and butyrylcholinesterase activity. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
24 12811800 Differential distribution of butyrylcholinesterase and acetylcholinesterase in the human thalamus. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
25 14622273 Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
26 23219600 Peripheral site and acyl pocket define selective inhibition of mouse butyrylcholinesterase by two biscarbamates. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
27 18167304 Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
28 16105444 [Relationship between the polymorphism of carboxylic esterases and genetic susceptibility to organophosphates pesticides exposure]. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
29 21493754 Naturally occurring variations in the human cholinesterase genes: heritability and association with cardiovascular and metabolic traits. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
30 29358722 Butyrylcholinesterase and Acetylcholinesterase polymorphisms in Multiple Sclerosis patients: implication in peripheral inflammation. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
31 16824336 [Activity of esterases and effect of genetic polymorphism in workers exposed to organophosphorus pesticides]. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
32 16801396 Comparison of polyethylene glycol-conjugated recombinant human acetylcholinesterase and serum human butyrylcholinesterase as bioscavengers of organophosphate compounds. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
33 27551784 Naturally Occurring Genetic Variants of Human Acetylcholinesterase and Butyrylcholinesterase and Their Potential Impact on the Risk of Toxicity from Cholinesterase Inhibitors. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
34 24399815 Synergistic effects of BuChE non-UU phenotype and paraoxonase (PON1) 55 M allele on the risk of systemic lupus erythematosus: influence on lipid and lipoprotein metabolism and oxidative stress, preliminary report. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
35 17192624 Acetyl- and butyrylcholinesterase activities decrease in human colon adenocarcinoma. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
36 21576115 Low preoperative plasma cholinesterase activity as a risk marker of postoperative delirium in elderly patients. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
37 20883446 Expression of cholinesterases in human kidney and its variation in renal cell carcinoma types. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
38 25179377 Association between butyrylcholinesterase activity and phenotypes, paraoxonase192 rs662 gene polymorphism and their enzymatic activity with severity of rheumatoid arthritis: correlation with systemic inflammatory markers and oxidative stress, preliminary report. Pubmed 4.936E-8 2.742E-6 2.257E-5 1.042E-4 2 2
39 18780301 Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. Pubmed 1.481E-7 7.442E-6 6.126E-5 3.126E-4 2 3
40 11929041 The effects of some porphyrinogenic drugs on the brain cholinergic system. Pubmed 1.481E-7 7.442E-6 6.126E-5 3.126E-4 2 3
41 12074828 Relation between butyrylcholinesterase K variant, paraoxonase 1 (PON1) Q and R and apolipoprotein E epsilon 4 genes in early-onset coronary artery disease. Pubmed 1.481E-7 7.442E-6 6.126E-5 3.126E-4 2 3
42 15690550 Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. Pubmed 1.481E-7 7.442E-6 6.126E-5 3.126E-4 2 3
43 17503475 Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. Pubmed 2.961E-7 1.389E-5 1.143E-4 6.250E-4 2 4
44 23063927 Copy number variation in ACHE/EPHB4 (7q22) and in BCHE/MME (3q26) genes in sporadic breast cancer. Pubmed 2.961E-7 1.389E-5 1.143E-4 6.250E-4 2 4
45 28544359 Discovery of potent carbonic anhydrase, acetylcholinesterase, and butyrylcholinesterase enzymes inhibitors: The new amides and thiazolidine-4-ones synthesized on an acetophenone base. Pubmed 2.961E-7 1.389E-5 1.143E-4 6.250E-4 2 4
46 20056567 Childhood brain tumors, residential insecticide exposure, and pesticide metabolism genes. Pubmed 7.400E-7 3.396E-5 2.796E-4 1.562E-3 2 6
47 28118357 Endochondral Ossification Is Accelerated in Cholinesterase-Deficient Mice and in Avian Mesenchymal Micromass Cultures. Pubmed 1.036E-6 4.653E-5 3.830E-4 2.187E-3 2 7
48 25269881 Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil. Pubmed 1.727E-5 3.605E-4 2.968E-3 3.646E-2 2 27
49 19762422 Convergent extension movements in growth plate chondrocytes require gpi-anchored cell surface proteins. Pubmed 1.860E-5 3.605E-4 2.968E-3 3.926E-2 2 28
50 27098205 Organization, evolution and functions of the human and mouse Ly6/uPAR family genes. Pubmed 2.287E-5 3.605E-4 2.968E-3 4.828E-2 2 31
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 149 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:COLQ COLQ interactions 3.044E-5 4.536E-3 2.533E-2 4.536E-3 2 19
2 int:PRIMA1 PRIMA1 interactions 9.036E-4 2.988E-2
1.669E-1
1.346E-1
 1 2
3 int:LYNX1 LYNX1 interactions 1.355E-3 2.988E-2
1.669E-1
2.019E-1
 1 3
4 int:PON3 PON3 interactions 1.355E-3 2.988E-2
1.669E-1
2.019E-1
 1 3
5 int:NCR3 NCR3 interactions 1.807E-3 2.988E-2
1.669E-1
2.692E-1
 1 4
6 int:PIGY PIGY interactions 1.807E-3 2.988E-2
1.669E-1
2.692E-1
 1 4
7 int:C8A C8A interactions 2.258E-3 2.988E-2
1.669E-1
3.364E-1
 1 5
8 int:MMP17 MMP17 interactions 2.258E-3 2.988E-2
1.669E-1
3.364E-1
 1 5
9 int:IL18RAP IL18RAP interactions 2.709E-3 2.988E-2
1.669E-1
4.036E-1
 1 6
10 int:PIGP PIGP interactions 2.709E-3 2.988E-2
1.669E-1
4.036E-1
 1 6
11 int:LOXL1 LOXL1 interactions 3.160E-3 2.988E-2
1.669E-1
4.708E-1
 1 7
12 int:PIGH PIGH interactions 3.160E-3 2.988E-2
1.669E-1
4.708E-1
 1 7
13 int:NCR1 NCR1 interactions 3.160E-3 2.988E-2
1.669E-1
4.708E-1
 1 7
14 int:ENTPD5 ENTPD5 interactions 3.160E-3 2.988E-2
1.669E-1
4.708E-1
 1 7
15 int:C9 C9 interactions 3.610E-3 2.988E-2
1.669E-1
5.379E-1
 1 8
16 int:CEP85L CEP85L interactions 3.610E-3 2.988E-2
1.669E-1
5.379E-1
 1 8
17 int:DPM2 DPM2 interactions 3.610E-3 2.988E-2
1.669E-1
5.379E-1
 1 8
18 int:CHRNA7 CHRNA7 interactions 3.610E-3 2.988E-2
1.669E-1
5.379E-1
 1 8
19 int:ACHE ACHE interactions 4.061E-3 3.025E-2
1.689E-1
6.050E-1
 1 9
20 int:SMR3B SMR3B interactions 4.061E-3 3.025E-2
1.689E-1
6.050E-1
 1 9
21 int:PON1 PON1 interactions 4.511E-3 3.201E-2
1.787E-1
6.721E-1
 1 10
22 int:HS3ST2 HS3ST2 interactions 5.411E-3 3.505E-2
1.958E-1
8.062E-1
 1 12
23 int:SLC6A8 SLC6A8 interactions 5.411E-3 3.505E-2
1.958E-1
8.062E-1
 1 12
24 int:THBS2 THBS2 interactions 6.760E-3 3.790E-2
2.116E-1
1.000E0
 1 15
25 int:PCDHB7 PCDHB7 interactions 7.209E-3 3.790E-2
2.116E-1
1.000E0
 1 16
26 int:PIGK PIGK interactions 7.209E-3 3.790E-2
2.116E-1
1.000E0
 1 16
27 int:GALK2 GALK2 interactions 7.209E-3 3.790E-2
2.116E-1
1.000E0
 1 16
28 int:PIGQ PIGQ interactions 7.209E-3 3.790E-2
2.116E-1
1.000E0
 1 16
29 int:HAND1 HAND1 interactions 9.004E-3 3.790E-2
2.116E-1
1.000E0
 1 20
30 int:CCDC107 CCDC107 interactions 9.004E-3 3.790E-2
2.116E-1
1.000E0
 1 20
31 int:MANEAL MANEAL interactions 9.004E-3 3.790E-2
2.116E-1
1.000E0
 1 20
32 int:CD8A CD8A interactions 9.452E-3 3.790E-2
2.116E-1
1.000E0
 1 21
33 int:CD2 CD2 interactions 9.452E-3 3.790E-2
2.116E-1
1.000E0
 1 21
34 int:TINAGL1 TINAGL1 interactions 9.901E-3 3.790E-2
2.116E-1
1.000E0
 1 22
35 int:SFXN5 SFXN5 interactions 1.080E-2 3.790E-2
2.116E-1
1.000E0
 1 24
36 int:HOXC9 HOXC9 interactions 1.124E-2 3.790E-2
2.116E-1
1.000E0
 1 25
37 int:ACTN3 ACTN3 interactions 1.124E-2 3.790E-2
2.116E-1
1.000E0
 1 25
38 int:IGFBP1 IGFBP1 interactions 1.124E-2 3.790E-2
2.116E-1
1.000E0
 1 25
39 int:ZNF609 ZNF609 interactions 1.169E-2 3.790E-2
2.116E-1
1.000E0
 1 26
40 int:PRSS50 PRSS50 interactions 1.169E-2 3.790E-2
2.116E-1
1.000E0
 1 26
41 int:SCGB1D4 SCGB1D4 interactions 1.214E-2 3.790E-2
2.116E-1
1.000E0
 1 27
42 int:BORA BORA interactions 1.214E-2 3.790E-2
2.116E-1
1.000E0
 1 27
43 int:EIF2D EIF2D interactions 1.259E-2 3.790E-2
2.116E-1
1.000E0
 1 28
44 int:NOP10 NOP10 interactions 1.303E-2 3.790E-2
2.116E-1
1.000E0
 1 29
45 int:BCHE BCHE interactions 1.303E-2 3.790E-2
2.116E-1
1.000E0
 1 29
46 int:NDUFB6 NDUFB6 interactions 1.303E-2 3.790E-2
2.116E-1
1.000E0
 1 29
47 int:CD9 CD9 interactions 1.303E-2 3.790E-2
2.116E-1
1.000E0
 1 29
48 int:PIGA PIGA interactions 1.303E-2 3.790E-2
2.116E-1
1.000E0
 1 29
49 int:POGLUT1 POGLUT1 interactions 1.348E-2 3.790E-2
2.116E-1
1.000E0
 1 30
50 int:MICU2 MICU2 interactions 1.348E-2 3.790E-2
2.116E-1
1.000E0
 1 30
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 9 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20q12-q13.12 20q12-q13.12 7.788E-4 3.505E-3 9.914E-3 7.009E-3 1 3
2 3q26.1-q26.2 3q26.1-q26.2 7.788E-4 3.505E-3 9.914E-3 7.009E-3 1 3
3 12q24.3 12q24.3 1.557E-3 4.087E-3 1.156E-2 1.401E-2 1 6
4 Xp22.1 Xp22.1 1.816E-3 4.087E-3 1.156E-2 1.635E-2 1 7
5 7q22 7q22 1.008E-2 1.667E-2 4.715E-2
9.074E-2
 1 39
6 7q21.3 7q21.3 1.111E-2 1.667E-2 4.715E-2
1.000E-1
 1 43
7 11p13 11p13 1.547E-2 1.989E-2
5.628E-2
1.393E-1
 1 60
8 7q22.1 7q22.1 2.972E-2 3.250E-2
9.194E-2
2.675E-1
 1 116
9 8q24.3 8q24.3 3.250E-2 3.250E-2
9.194E-2
2.925E-1
 1 127
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 14 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 9 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 680 Phosphatidylinositol glycan anchor biosynthesis genenames.org 3.538E-5 3.184E-4 9.008E-4 3.184E-4 2 21
2 1226 LY6/PLAUR domain containing genenames.org 9.425E-5 4.241E-4 1.200E-3 8.482E-4 2 34
3 463 Paraoxonases genenames.org 1.319E-3 3.956E-3 1.119E-2 1.187E-2 1 3
4 572 Glypicans genenames.org 2.636E-3 5.930E-3 1.678E-2 2.372E-2 1 6
5 427 Glycosyl transferases group 1 domain containing genenames.org 4.389E-3 7.901E-3 2.235E-2 3.951E-2 1 10
6 891 Matrix metallopeptidases genenames.org 1.051E-2 1.576E-2 4.458E-2
9.456E-2
 1 24
7 492 Complement system|Sushi domain containing genenames.org 1.572E-2 1.818E-2
5.142E-2
1.415E-1
 1 36
8 454 Blood group antigens genenames.org 1.616E-2 1.818E-2
5.142E-2
1.454E-1
 1 37
Show 3 more annotations

13: Coexpression [Display Chart] 9 input genes in category / 657 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M8882 Genes down-regulated in hematopoietic stem cells versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.521E-5 9.993E-3
7.060E-2
 9.993E-3 3 133
2 M2477 Genes up-regulated hT-RPE cells (immortalized retinal pigment epithelium) by MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.733E-5 2.869E-2
2.027E-1
5.737E-2
 3 239

14: Coexpression Atlas [Display Chart] 9 input genes in category / 672 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 6 input genes in category / 17 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17170 MODULE 401 Genes in the cancer module 401. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.561E-5 6.053E-4 2.082E-3 6.053E-4 2 16

16: MicroRNA [Display Chart] 9 input genes in category / 259 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1304-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.237E-4 3.204E-2
1.966E-1
 3.204E-2 2 135

17: Drug [Display Chart] 9 input genes in category / 3345 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C082366 4-nitrophenyl 2-propylmethylphosphonate CTD 4.230E-11 4.716E-8 4.100E-7 1.415E-7 3 3
2 ctd:C451779 S-(N,N-diethylaminoethyl) isobutyl methylphosphothiolate CTD 4.230E-11 4.716E-8 4.100E-7 1.415E-7 3 3
3 ctd:C042896 ethyl 4-nitrophenyl methylphosphonate CTD 4.230E-11 4.716E-8 4.100E-7 1.415E-7 3 3
4 CID000009453 coroxon Stitch 1.692E-10 1.415E-7 1.230E-6 5.659E-7 3 4
5 ctd:C053914 cyclohexyl methylphosphonofluoridate CTD 4.228E-10 1.572E-7 1.366E-6 1.414E-6 3 5
6 CID000009300 crufomate Stitch 4.228E-10 1.572E-7 1.366E-6 1.414E-6 3 5
7 ctd:D010091 Oximes CTD 4.228E-10 1.572E-7 1.366E-6 1.414E-6 3 5
8 ctd:D009768 Obidoxime Chloride CTD 4.228E-10 1.572E-7 1.366E-6 1.414E-6 3 5
9 ctd:C011960 oxamyl CTD 4.228E-10 1.572E-7 1.366E-6 1.414E-6 3 5
10 CID000135020 vinyl phosphate Stitch 8.455E-10 2.571E-7 2.235E-6 2.828E-6 3 6
11 CID000017777 ImHp Stitch 8.455E-10 2.571E-7 2.235E-6 2.828E-6 3 6
12 ctd:C009374 tabun CTD 1.479E-9 3.806E-7 3.309E-6 4.948E-6 3 7
13 CID000013526 demeton-S-methyl Stitch 1.479E-9 3.806E-7 3.309E-6 4.948E-6 3 7
14 ctd:C009680 VX CTD 2.366E-9 4.656E-7 4.048E-6 7.916E-6 3 8
15 CID000281832 K3-3 Stitch 2.366E-9 4.656E-7 4.048E-6 7.916E-6 3 8
16 CID000448270 AC1L9LSA Stitch 2.366E-9 4.656E-7 4.048E-6 7.916E-6 3 8
17 CID000016738 fenitrooxon Stitch 2.366E-9 4.656E-7 4.048E-6 7.916E-6 3 8
18 ctd:D010755 Organophosphates CTD 3.549E-9 5.653E-7 4.914E-6 1.187E-5 3 9
19 CID000065872 eptastigmine Stitch 3.549E-9 5.653E-7 4.914E-6 1.187E-5 3 9
20 CID000007631 phenylthioacetate Stitch 3.549E-9 5.653E-7 4.914E-6 1.187E-5 3 9
21 CID000014481 malathion diacid Stitch 3.549E-9 5.653E-7 4.914E-6 1.187E-5 3 9
22 CID000197063 methylphosphonothiolate Stitch 5.069E-9 7.707E-7 6.700E-6 1.696E-5 3 10
23 ctd:C000912 diazoxon CTD 6.969E-9 9.712E-7 8.443E-6 2.331E-5 3 11
24 ctd:C100082 malaoxon CTD 6.969E-9 9.712E-7 8.443E-6 2.331E-5 3 11
25 CID000016632 benzoylcholine Stitch 9.290E-9 1.072E-6 9.314E-6 3.107E-5 3 12
26 ctd:D000448 Aldicarb CTD 9.290E-9 1.072E-6 9.314E-6 3.107E-5 3 12
27 CID005359236 trimedoxime Stitch 9.290E-9 1.072E-6 9.314E-6 3.107E-5 3 12
28 CID000002871 coumaphos Stitch 9.290E-9 1.072E-6 9.314E-6 3.107E-5 3 12
29 ctd:C008480 methylparaoxon CTD 9.290E-9 1.072E-6 9.314E-6 3.107E-5 3 12
30 CID000024723 demeton-S Stitch 1.207E-8 1.346E-6 1.170E-5 4.039E-5 3 13
31 CID009572779 (2E)-1-methyl-2H-pyridine-2-carbaldehyde oxime Stitch 1.536E-8 1.658E-6 1.441E-5 5.139E-5 3 14
32 ctd:D009943 Organophosphorus Compounds CTD 1.920E-8 1.889E-6 1.642E-5 6.423E-5 3 15
33 CID000000655 DETP Stitch 1.920E-8 1.889E-6 1.642E-5 6.423E-5 3 15
34 CID000070272 p-chloro-N-methylaniline Stitch 1.920E-8 1.889E-6 1.642E-5 6.423E-5 3 15
35 CID000031070 fenamiphos Stitch 2.363E-8 2.258E-6 1.963E-5 7.903E-5 3 16
36 CID000013676 fonofos Stitch 2.868E-8 2.443E-6 2.123E-5 9.595E-5 3 17
37 CID000008289 triphenyl phosphate Stitch 3.442E-8 2.443E-6 2.123E-5 1.151E-4 3 18
38 CID000013130 methyl phosphate Stitch 4.806E-8 2.443E-6 2.123E-5 1.608E-4 3 20
39 CID000073709 beta-naphthyl acetate Stitch 4.806E-8 2.443E-6 2.123E-5 1.608E-4 3 20
40 CID000023353 alpha-Te Stitch 4.806E-8 2.443E-6 2.123E-5 1.608E-4 3 20
41 CID000013708 methyl paraoxon Stitch 5.606E-8 2.443E-6 2.123E-5 1.875E-4 3 21
42 CID000029950 phenyl valerate Stitch 6.490E-8 2.443E-6 2.123E-5 2.171E-4 3 22
43 CID000023017 3,5,6-trichloro-2-pyridinol Stitch 7.462E-8 2.443E-6 2.123E-5 2.496E-4 3 23
44 CID000020689 butyrylthiocholine Stitch 7.462E-8 2.443E-6 2.123E-5 2.496E-4 3 23
45 ctd:D007531 Isoflurophate CTD 8.526E-8 2.443E-6 2.123E-5 2.852E-4 3 24
46 CID000016421 map J Stitch 8.526E-8 2.443E-6 2.123E-5 2.852E-4 3 24
47 CID000002268 azinphos-methyl Stitch 8.526E-8 2.443E-6 2.123E-5 2.852E-4 3 24
48 CID000092421 trinexapac-ethyl Stitch 9.687E-8 2.443E-6 2.123E-5 3.240E-4 3 25
49 CID000009738 mipafox Stitch 1.095E-7 2.443E-6 2.123E-5 3.662E-4 3 26
50 CID000013134 dimethyl phosphate Stitch 1.231E-7 2.443E-6 2.123E-5 4.119E-4 3 27
Show 45 more annotations

18: Disease [Display Chart] 9 input genes in category / 519 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0700359 Organophosphate poisoning DisGeNET Curated 4.737E-10 2.459E-7 1.679E-6 2.459E-7 3 4
2 C0019050 Hemoglobinuria, Paroxysmal DisGeNET Curated 2.742E-7 4.744E-5 3.240E-4 1.423E-4 2 2
3 C0877854 Cerebral Arteriosclerosis DisGeNET BeFree 2.742E-7 4.744E-5 3.240E-4 1.423E-4 2 2
4 C2981142 Refractory anemia, without ringed sideroblasts, without excess blasts DisGeNET BeFree 5.283E-7 6.855E-5 4.682E-4 2.742E-4 3 31
5 C0011269 Dementia, Vascular DisGeNET Curated 3.600E-6 3.554E-4 2.427E-3 1.868E-3 3 58
6 C2676767 CD59 Deficiency DisGeNET Curated 4.108E-6 3.554E-4 2.427E-3 2.132E-3 2 6
7 C0024790 Paroxysmal nocturnal hemoglobinuria DisGeNET Curated 5.575E-6 4.133E-4 2.823E-3 2.893E-3 3 67
8 C0235574 Intravascular hemolysis DisGeNET BeFree 9.851E-6 6.391E-4 4.365E-3 5.113E-3 2 9
9 C0040034 Thrombocytopenia DisGeNET Curated 1.348E-5 7.775E-4 5.310E-3 6.997E-3 4 300
10 C1848395 Large for gestational age DisGeNET Curated 1.504E-5 7.807E-4 5.332E-3 7.807E-3 2 11
11 C1279420 Anxiety neurosis (finding) DisGeNET BeFree 2.487E-5 1.134E-3 7.744E-3 1.291E-2 2 14
12 C0002878 Anemia, Hemolytic DisGeNET Curated 2.762E-5 1.134E-3 7.744E-3 1.433E-2 3 114
13 C0019048 Hemoglobinuria DisGeNET Curated 2.868E-5 1.134E-3 7.744E-3 1.489E-2 2 15
14 C0948242 Nuchal bleb, familial DisGeNET Curated 3.277E-5 1.134E-3 7.744E-3 1.701E-2 2 16
15 C0700613 Anxiety state DisGeNET BeFree 3.277E-5 1.134E-3 7.744E-3 1.701E-2 2 16
16 C0020557 Hypertriglyceridemia DisGeNET Curated 6.269E-5 2.033E-3 1.389E-2 3.253E-2 3 150
17 C0235032 Neurotoxicity Syndromes DisGeNET Curated 8.850E-5 2.702E-3 1.845E-2 4.593E-2 2 26
18 C0002894 Refractory anaemia with excess blasts DisGeNET Curated 1.348E-4 3.888E-3 2.655E-2
6.998E-2
 2 32
19 C0020473 Hyperlipidemia DisGeNET Curated 1.607E-4 4.194E-3 2.864E-2
8.342E-2
 3 206
20 C2717961 Thrombotic Microangiopathies DisGeNET Curated 1.616E-4 4.194E-3 2.864E-2
8.387E-2
 2 35
21 C0005818 Blood Platelet Disorders DisGeNET Curated 1.711E-4 4.228E-3 2.887E-2
8.878E-2
 2 36
22 C0751882 Myasthenic Syndromes, Congenital DisGeNET Curated 2.010E-4 4.742E-3 3.239E-2
1.043E-1
 2 39
23 C0001969 Alcoholic Intoxication DisGeNET Curated 2.334E-4 4.970E-3 3.394E-2
1.211E-1
 2 42
24 C0522224 Paralysed DisGeNET Curated 2.334E-4 4.970E-3 3.394E-2
1.211E-1
 2 42
25 C0015672 Fatigue DisGeNET Curated 3.886E-4 4.970E-3 3.394E-2
2.017E-1
 3 278
26 C0002893 Refractory anemias DisGeNET Curated 4.354E-4 4.970E-3 3.394E-2
2.260E-1
 3 289
27 C1842937 AURAL ATRESIA, CONGENITAL DisGeNET BeFree 4.773E-4 4.970E-3 3.394E-2
2.477E-1
 2 60
28 C0041755 Adverse reaction to drug DisGeNET Curated 4.933E-4 4.970E-3 3.394E-2
2.560E-1
 2 61
29 C0544886 Somatic mutation DisGeNET Curated 5.096E-4 4.970E-3 3.394E-2
2.645E-1
 2 62
30 C0333463 Senile Plaques DisGeNET BeFree 5.397E-4 4.970E-3 3.394E-2
2.801E-1
 3 311
31 C0011265 Presenile dementia DisGeNET BeFree 5.551E-4 4.970E-3 3.394E-2
2.881E-1
 3 314
32 C0002879 Anemia, Hemolytic, Acquired DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
33 C0009176 Cocaine intoxication DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
34 cv:C3275508 Multiple congenital anomalies-hypotonia-seizures syndrome 2 Clinical Variations 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
35 cv:CN179948 Multiple congenital anomalies-hypotonia-seizures syndrome 3 Clinical Variations 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
36 C0232066 Induced apnea DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
37 C4024905 Abnormality of the pons DisGeNET Curated 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
38 C0001828 Agricultural Workers' Diseases DisGeNET Curated 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
39 cv:C2674665 Microvascular complications of diabetes 5 Clinical Variations 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
40 OMIN:112100 YT BLOOD GROUP ANTIGEN OMIM 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
41 C3275508 MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 2 DisGeNET Curated 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
42 cv:CN035126 Paroxysmal nocturnal hemoglobinuria 1 Clinical Variations 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
43 C3809356 MULTIPLE CONGENITAL ANOMALIES-HYPOTONIA-SEIZURES SYNDROME 3 DisGeNET Curated 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
44 C0852336 Immune Hemolytic Anemia DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
45 OMIN:612300 CD59 DEFICIENCY OMIM 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
46 cv:C2676767 Cd59 deficiency Clinical Variations 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
47 C0343560 Congenital varicella syndrome DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
48 C0581375 Double coronary vessel disease DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
49 C0033831 Psychological pseudocyesis DisGeNET BeFree 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
50 C3806670 PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 1 DisGeNET Curated 5.554E-4 4.970E-3 3.394E-2
2.882E-1
 1 1
Show 45 more annotations