Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc138_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 19 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004725 protein tyrosine phosphatase activity 6.529E-19 1.240E-17 4.401E-17 1.240E-17 8 103
2 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity 5.907E-18 5.612E-17 1.991E-16 1.122E-16 6 17
3 GO:0004721 phosphoprotein phosphatase activity 1.085E-16 6.871E-16 2.438E-15 2.061E-15 8 192
4 GO:0019198 transmembrane receptor protein phosphatase activity 1.828E-15 8.684E-15 3.081E-14 3.474E-14 6 40
5 GO:0016791 phosphatase activity 2.464E-15 9.364E-15 3.322E-14 4.682E-14 8 282
6 GO:0042578 phosphoric ester hydrolase activity 7.317E-14 2.317E-13 8.220E-13 1.390E-12 8 429
7 GO:0070097 delta-catenin binding 3.425E-3 9.297E-3 3.298E-2
6.508E-2
 1 8
8 GO:0045295 gamma-catenin binding 5.561E-3 1.321E-2 4.685E-2
1.057E-1
 1 13
9 GO:0005161 platelet-derived growth factor receptor binding 7.266E-3 1.534E-2
5.442E-2
1.381E-1
 1 17
10 GO:0017134 fibroblast growth factor binding 1.152E-2 2.159E-2
7.661E-2
2.189E-1
 1 27
11 GO:0051019 mitogen-activated protein kinase binding 1.279E-2 2.159E-2
7.661E-2
2.430E-1
 1 30
12 GO:0030507 spectrin binding 1.364E-2 2.159E-2
7.661E-2
2.591E-1
 1 32
Show 7 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 276 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035335 peptidyl-tyrosine dephosphorylation 8.281E-16 2.286E-13 1.417E-12 2.286E-13 7 100
2 GO:0006470 protein dephosphorylation 1.251E-14 1.726E-12 1.070E-11 3.452E-12 8 344
3 GO:0016311 dephosphorylation 9.992E-14 9.193E-12 5.699E-11 2.758E-11 8 445
4 GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway 3.387E-6 2.337E-4 1.449E-3 9.349E-4 2 7
5 GO:0048709 oligodendrocyte differentiation 6.848E-6 3.780E-4 2.343E-3 1.890E-3 3 94
6 GO:0010001 glial cell differentiation 7.592E-5 3.492E-3 2.165E-2 2.095E-2 3 210
7 GO:0032868 response to insulin 1.530E-4 6.033E-3 3.740E-2 4.223E-2 3 266
8 GO:0042063 gliogenesis 1.762E-4 6.079E-3 3.768E-2 4.863E-2 3 279
9 GO:0014015 positive regulation of gliogenesis 2.918E-4 8.948E-3
5.547E-2
8.053E-2
 2 61
10 GO:0021766 hippocampus development 5.144E-4 1.388E-2
8.603E-2
1.420E-1
 2 81
11 GO:1900006 positive regulation of dendrite development 5.531E-4 1.388E-2
8.603E-2
1.526E-1
 2 84
12 GO:0048814 regulation of dendrite morphogenesis 6.206E-4 1.395E-2
8.646E-2
1.713E-1
 2 89
13 GO:0043434 response to peptide hormone 6.804E-4 1.395E-2
8.646E-2
1.878E-1
 3 442
14 GO:0050769 positive regulation of neurogenesis 7.888E-4 1.395E-2
8.646E-2
2.177E-1
 3 465
15 GO:1901652 response to peptide 8.495E-4 1.395E-2
8.646E-2
2.345E-1
 3 477
16 GO:1900149 positive regulation of Schwann cell migration 8.590E-4 1.395E-2
8.646E-2
2.371E-1
 1 2
17 GO:1990502 dense core granule maturation 8.590E-4 1.395E-2
8.646E-2
2.371E-1
 1 2
18 GO:0021761 limbic system development 9.458E-4 1.424E-2
8.828E-2
2.611E-1
 2 110
19 GO:0014013 regulation of gliogenesis 9.803E-4 1.424E-2
8.828E-2
2.706E-1
 2 112
20 GO:0008286 insulin receptor signaling pathway 1.238E-3 1.709E-2
1.059E-1
3.417E-1
 2 126
21 GO:0048813 dendrite morphogenesis 1.569E-3 1.810E-2
1.122E-1
4.329E-1
 2 142
22 GO:1903977 positive regulation of glial cell migration 1.717E-3 1.810E-2
1.122E-1
4.740E-1
 1 4
23 GO:1900147 regulation of Schwann cell migration 1.717E-3 1.810E-2
1.122E-1
4.740E-1
 1 4
24 GO:0036135 Schwann cell migration 1.717E-3 1.810E-2
1.122E-1
4.740E-1
 1 4
25 GO:1903385 regulation of homophilic cell adhesion 1.717E-3 1.810E-2
1.122E-1
4.740E-1
 1 4
26 GO:0050773 regulation of dendrite development 1.748E-3 1.810E-2
1.122E-1
4.824E-1
 2 150
27 GO:0038127 ERBB signaling pathway 1.771E-3 1.810E-2
1.122E-1
4.888E-1
 2 151
28 GO:0043409 negative regulation of MAPK cascade 2.135E-3 2.104E-2
1.305E-1
5.892E-1
 2 166
29 GO:0021543 pallium development 2.369E-3 2.254E-2
1.398E-1
6.538E-1
 2 175
30 GO:0010572 positive regulation of platelet activation 2.575E-3 2.328E-2
1.443E-1
7.107E-1
 1 6
31 GO:0010810 regulation of cell-substrate adhesion 2.614E-3 2.328E-2
1.443E-1
7.215E-1
 2 184
32 GO:0032869 cellular response to insulin stimulus 3.326E-3 2.868E-2
1.778E-1
9.179E-1
 2 208
33 GO:0030336 negative regulation of cell migration 3.845E-3 2.938E-2
1.821E-1
1.000E0
 2 224
34 GO:0097105 presynaptic membrane assembly 3.860E-3 2.938E-2
1.821E-1
1.000E0
 1 9
35 GO:0060242 contact inhibition 3.860E-3 2.938E-2
1.821E-1
1.000E0
 1 9
36 GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules 4.049E-3 2.938E-2
1.821E-1
1.000E0
 2 230
37 GO:2000146 negative regulation of cell motility 4.223E-3 2.938E-2
1.821E-1
1.000E0
 2 235
38 GO:0070445 regulation of oligodendrocyte progenitor proliferation 4.289E-3 2.938E-2
1.821E-1
1.000E0
 1 10
39 GO:1903975 regulation of glial cell migration 4.289E-3 2.938E-2
1.821E-1
1.000E0
 1 10
40 GO:0070444 oligodendrocyte progenitor proliferation 4.289E-3 2.938E-2
1.821E-1
1.000E0
 1 10
41 GO:0016358 dendrite development 4.364E-3 2.938E-2
1.821E-1
1.000E0
 2 239
42 GO:0043116 negative regulation of vascular permeability 4.716E-3 3.099E-2
1.921E-1
1.000E0
 1 11
43 GO:0021537 telencephalon development 5.143E-3 3.155E-2
1.956E-1
1.000E0
 2 260
44 GO:0010642 negative regulation of platelet-derived growth factor receptor signaling pathway 5.144E-3 3.155E-2
1.956E-1
1.000E0
 1 12
45 GO:0090557 establishment of endothelial intestinal barrier 5.144E-3 3.155E-2
1.956E-1
1.000E0
 1 12
46 GO:0051271 negative regulation of cellular component movement 5.456E-3 3.272E-2
2.028E-1
1.000E0
 2 268
47 GO:2001224 positive regulation of neuron migration 5.572E-3 3.272E-2
2.028E-1
1.000E0
 1 13
48 GO:0010759 positive regulation of macrophage chemotaxis 5.999E-3 3.379E-2
2.095E-1
1.000E0
 1 14
49 GO:0001553 luteinization 5.999E-3 3.379E-2
2.095E-1
1.000E0
 1 14
50 GO:0010976 positive regulation of neuron projection development 6.191E-3 3.401E-2
2.109E-1
1.000E0
 2 286
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 31 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0032587 ruffle membrane 5.282E-4 1.301E-2
5.239E-2
 1.637E-2 2 84
2 GO:0072534 perineuronal net 8.393E-4 1.301E-2
5.239E-2
 2.602E-2 1 2
3 GO:0031256 leading edge membrane 1.670E-3 1.637E-2
6.594E-2
5.176E-2
 2 150
4 GO:0001726 ruffle 2.113E-3 1.637E-2
6.594E-2
6.549E-2
 2 169
5 GO:0031253 cell projection membrane 7.902E-3 4.899E-2
1.973E-1
2.449E-1
 2 332

4: Human Phenotype [Display Chart] 4 input genes in category / 32 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 233 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 8 input genes in category / 39 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00194 PTPc SMART 8.050E-23 2.478E-21 1.054E-20 3.140E-21 8 36
2 PS50055 TYR PHOSPHATASE PTP PROSITE 1.637E-22 2.478E-21 1.054E-20 6.383E-21 8 39
3 PF00102 Y phosphatase Pfam 2.542E-22 2.478E-21 1.054E-20 9.914E-21 8 41
4 IPR000242 PTPase domain InterPro 2.542E-22 2.478E-21 1.054E-20 9.914E-21 8 41
5 IPR003595 Tyr Pase cat InterPro 5.899E-21 3.835E-20 1.631E-19 2.301E-19 8 59
6 SM00404 PTPc motif SMART 5.899E-21 3.835E-20 1.631E-19 2.301E-19 8 59
7 IPR016130 Tyr Pase AS InterPro 3.576E-20 1.992E-19 8.475E-19 1.395E-18 8 73
8 PS00383 TYR PHOSPHATASE 1 PROSITE 1.412E-19 6.063E-19 2.579E-18 5.505E-18 8 86
9 PS50056 TYR PHOSPHATASE 2 PROSITE 1.555E-19 6.063E-19 2.579E-18 6.063E-18 8 87
10 IPR000387 TYR PHOSPHATASE dom InterPro 1.555E-19 6.063E-19 2.579E-18 6.063E-18 8 87
11 3.90.190.10 - Gene3D 2.476E-19 8.780E-19 3.734E-18 9.658E-18 8 92
12 IPR029021 Prot-tyrosine phosphatase-like InterPro 4.555E-19 1.480E-18 6.296E-18 1.776E-17 8 99
13 IPR016336 Tyr Pase rcpt a/e-type InterPro 1.596E-7 4.787E-7 2.036E-6 6.223E-6 2 2
14 PF00041 fn3 Pfam 3.670E-7 1.022E-6 4.349E-6 1.431E-5 4 162
15 SM00060 FN3 SMART 6.247E-7 1.624E-6 6.908E-6 2.436E-5 4 185
16 PS50853 FN3 PROSITE 8.363E-7 2.038E-6 8.670E-6 3.261E-5 4 199
17 IPR003961 FN3 dom InterPro 1.017E-6 2.334E-6 9.926E-6 3.967E-5 4 209
18 IPR027262 Tyr Pase rcpt alpha InterPro 4.270E-4 8.765E-4 3.728E-3 1.665E-2 1 1
19 IPR033522 PTPRN InterPro 4.270E-4 8.765E-4 3.728E-3 1.665E-2 1 1
20 IPR016334 Tyr Pase rcpt R/non-rcpt 5 InterPro 8.539E-4 1.514E-3 6.438E-3 3.330E-2 1 2
21 IPR021613 Receptor IA-2 dom InterPro 8.539E-4 1.514E-3 6.438E-3 3.330E-2 1 2
22 PF11548 Receptor IA-2 Pfam 8.539E-4 1.514E-3 6.438E-3 3.330E-2 1 2
23 IPR008356 Tyr Pase KIM-con InterPro 1.281E-3 1.998E-3 8.497E-3 4.994E-2 1 3
24 PF14948 RESP18 Pfam 1.281E-3 1.998E-3 8.497E-3 4.994E-2 1 3
25 IPR029403 RESP18 dom InterPro 1.281E-3 1.998E-3 8.497E-3 4.994E-2 1 3
26 PF07679 I-set Pfam 2.752E-3 3.701E-3 1.574E-2
1.073E-1
 2 190
27 PF00047 ig Pfam 2.752E-3 3.701E-3 1.574E-2
1.073E-1
 2 190
28 IPR013098 Ig I-set InterPro 2.752E-3 3.701E-3 1.574E-2
1.073E-1
 2 190
29 IPR013151 Immunoglobulin InterPro 2.752E-3 3.701E-3 1.574E-2
1.073E-1
 2 190
30 IPR003598 Ig sub2 InterPro 4.174E-3 5.251E-3 2.233E-2
1.628E-1
 2 235
31 SM00408 IGc2 SMART 4.174E-3 5.251E-3 2.233E-2
1.628E-1
 2 235
32 IPR001148 Carbonic anhydrase a InterPro 7.237E-3 7.841E-3 3.335E-2
2.823E-1
 1 17
33 SM01057 Carb anhydrase SMART 7.237E-3 7.841E-3 3.335E-2
2.823E-1
 1 17
34 PS51144 ALPHA CA 2 PROSITE 7.237E-3 7.841E-3 3.335E-2
2.823E-1
 1 17
35 3.10.200.10 - Gene3D 7.237E-3 7.841E-3 3.335E-2
2.823E-1
 1 17
36 PF00194 Carb anhydrase Pfam 7.237E-3 7.841E-3 3.335E-2
2.823E-1
 1 17
37 IPR003599 Ig sub InterPro 1.290E-2 1.323E-2
5.630E-2
5.029E-1
 2 421
38 SM00409 IG SMART 1.290E-2 1.323E-2
5.630E-2
5.029E-1
 2 421
39 PS50835 IG LIKE PROSITE 1.735E-2 1.735E-2
7.380E-2
6.767E-1
 2 492
Show 34 more annotations

7: Pathway [Display Chart] 7 input genes in category / 59 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1383059 SALM protein interactions at the synapses BioSystems: REACTOME 5.662E-5 3.340E-3 1.558E-2 3.340E-3 2 21
2 1427849 Protein-protein interactions at synapses BioSystems: REACTOME 6.987E-4 2.061E-2
9.612E-2
 4.122E-2 2 73

8: Pubmed [Display Chart] 8 input genes in category / 712 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 7832766 A novel receptor-type protein tyrosine phosphatase with a single catalytic domain is specifically expressed in mouse brain. Pubmed 2.084E-17 1.484E-14 1.060E-13 1.484E-14 5 10
2 19727691 Protein tyrosine phosphatases expression during development of mouse superior colliculus. Pubmed 2.482E-16 5.891E-14 4.210E-13 1.767E-13 5 15
3 18308476 Receptor protein tyrosine phosphatases are expressed by cycling retinal progenitor cells and involved in neuronal development of mouse retina. Pubmed 2.482E-16 5.891E-14 4.210E-13 1.767E-13 5 15
4 2170109 Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. Pubmed 1.184E-14 2.108E-12 1.506E-11 8.432E-12 4 6
5 12376545 Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. Pubmed 2.763E-14 3.935E-12 2.812E-11 1.967E-11 4 7
6 10777529 Multiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPs. Pubmed 6.030E-11 7.156E-9 5.114E-8 4.294E-8 3 5
7 19167335 Large-scale structural analysis of the classical human protein tyrosine phosphatome. Pubmed 1.403E-10 1.427E-8 1.020E-7 9.992E-8 4 47
8 1454056 Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain. Pubmed 2.110E-10 1.669E-8 1.193E-7 1.502E-7 3 7
9 1932742 Identification of novel protein tyrosine phosphatases of hematopoietic cells by polymerase chain reaction amplification. Pubmed 2.110E-10 1.669E-8 1.193E-7 1.502E-7 3 7
10 20201926 Human variation in alcohol response is influenced by variation in neuronal signaling genes. Pubmed 2.678E-8 1.608E-6 1.149E-5 1.907E-5 4 171
11 9566880 The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
12 8575779 Chromosomal location of murine protein tyrosine phosphatase (Ptprj and Ptpre) genes. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
13 16338072 Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
14 24242166 Immunohistochemical and Western blot analysis of two protein tyrosine phosphatase receptors, R and Z1, in colorectal carcinoma, colon adenoma and normal colon tissues. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
15 24694598 Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
16 16870705 Tyrosine phosphatases epsilon and alpha perform specific and overlapping functions in regulation of voltage-gated potassium channels in Schwann cells. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
17 9357975 Expression of protein-tyrosine phosphatases in the major insulin target tissues. Pubmed 3.839E-8 1.608E-6 1.149E-5 2.733E-5 2 2
18 20139422 Trans-synaptic adhesions between netrin-G ligand-3 (NGL-3) and receptor tyrosine phosphatases LAR, protein-tyrosine phosphatase delta (PTPdelta), and PTPsigma via specific domains regulate excitatory synapse formation. Pubmed 1.152E-7 3.905E-6 2.790E-5 8.200E-5 2 3
19 19812040 Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination. Pubmed 1.152E-7 3.905E-6 2.790E-5 8.200E-5 2 3
20 12598528 Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. Pubmed 1.152E-7 3.905E-6 2.790E-5 8.200E-5 2 3
21 12364328 Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activity. Pubmed 1.152E-7 3.905E-6 2.790E-5 8.200E-5 2 3
22 22140262 The cytokine midkine and its receptor RPTPζ regulate B cell survival in a pathway induced by CD74. Pubmed 2.303E-7 7.129E-6 5.095E-5 1.640E-4 2 4
23 8524829 The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. Pubmed 2.303E-7 7.129E-6 5.095E-5 1.640E-4 2 4
24 2169617 Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Pubmed 3.838E-7 1.139E-5 8.136E-5 2.733E-4 2 5
25 23345436 Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases. Pubmed 5.756E-7 1.576E-5 1.126E-4 4.098E-4 2 6
26 16273344 The IA-2 interactome. Pubmed 5.756E-7 1.576E-5 1.126E-4 4.098E-4 2 6
27 14757526 Receptor-like protein tyrosine phosphatase zeta/RPTP beta is expressed on tangentially aligned neurons in early mouse neocortex. Pubmed 8.058E-7 2.049E-5 1.464E-4 5.737E-4 2 7
28 15978577 Transmembrane homodimerization of receptor-like protein tyrosine phosphatases. Pubmed 8.058E-7 2.049E-5 1.464E-4 5.737E-4 2 7
29 9624153 Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. Pubmed 2.531E-6 6.214E-5 4.441E-4 1.802E-3 2 12
30 8875997 Cloning and characterization of PTP-K1, a novel nonreceptor protein tyrosine phosphatase highly expressed in bone marrow. Pubmed 4.600E-6 1.092E-4 7.802E-4 3.275E-3 2 16
31 29031500 Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Pubmed 1.443E-5 3.315E-4 2.369E-3 1.028E-2 3 246
32 16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. Pubmed 1.645E-5 3.660E-4 2.615E-3 1.171E-2 3 257
33 15588985 Substrate-trapping techniques in the identification of cellular PTP targets. Pubmed 4.679E-5 4.971E-4 3.552E-3 3.332E-2 2 50
34 11471062 High-throughput sequence identification of gene coding variants within alcohol-related QTLs. Pubmed 5.879E-5 4.971E-4 3.552E-3 4.186E-2 2 56
35 17611635 Detection of proteolytic cleavages of diabetes-associated protein IA-2 beta in the pancreas and the brain using novel anti-IA-2 beta monoclonal antibodies. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
36 11796915 Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
37 10339428 Targeted disruption of the tyrosine phosphatase PTPalpha leads to constitutive downregulation of the kinases Src and Fyn. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
38 17147696 Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
39 18003890 Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
40 21270193 Islet autoantibody seroconversion in the DPT-1 study: justification for repeat screening throughout childhood. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
41 23889985 Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
42 9780142 Negative regulation of human T cell activation by the receptor-type protein tyrosine phosphatase CD148. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
43 18776043 The Wnt antagonist Dickkopf-1 mobilizes vasculogenic progenitor cells via activation of the bone marrow endosteal stem cell niche. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
44 14555979 A role for receptor tyrosine phosphatase zeta in glioma cell migration. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
45 25571783 Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
46 23144976 Protein tyrosine phosphatase receptor type z negatively regulates oligodendrocyte differentiation and myelination. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
47 23060448 Loss of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) promotes prostate cancer metastasis. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
48 29420785 Interaction of receptor type of protein tyrosine phosphatase sigma (RPTPÏ?) with a glycosaminoglycan library. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
49 10705342 Protein tyrosine phosphatase (PC12, Br7,S1) family: expression characterization in the adult human and mouse. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
50 22832403 Increased expression of receptor phosphotyrosine phosphatase-β/ζ is associated with molecular, cellular, behavioral and cognitive schizophrenia phenotypes. Pubmed 2.095E-4 4.971E-4 3.552E-3
1.491E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 344 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PTPRS PTPRS interactions 2.696E-11 9.274E-9 5.953E-8 9.274E-9 5 63
2 int:PTPRE PTPRE interactions 4.966E-9 8.542E-7 5.483E-6 1.708E-6 4 53
3 int:PTPRA PTPRA interactions 1.075E-8 1.233E-6 7.916E-6 3.699E-6 4 64
4 int:PTPRD PTPRD interactions 1.550E-8 1.333E-6 8.558E-6 5.333E-6 4 70
5 int:SAAL1 SAAL1 interactions 9.111E-7 6.269E-5 4.024E-4 3.134E-4 3 46
6 int:XPO4 XPO4 interactions 1.325E-6 7.596E-5 4.876E-4 4.557E-4 3 52
7 int:XPOT XPOT interactions 2.048E-6 1.006E-4 6.460E-4 7.045E-4 3 60
8 int:FYN FYN interactions 2.769E-6 1.191E-4 7.644E-4 9.526E-4 4 254
9 int:PTPRF PTPRF interactions 3.412E-6 1.304E-4 8.373E-4 1.174E-3 3 71
10 int:TNPO3 TNPO3 interactions 4.713E-6 1.621E-4 1.041E-3 1.621E-3 3 79
11 int:TNPO1 TNPO1 interactions 6.754E-6 2.112E-4 1.356E-3 2.324E-3 3 89
12 int:SEC61A2 SEC61A2 interactions 8.027E-6 2.301E-4 1.477E-3 2.761E-3 2 10
13 int:PTPRM PTPRM interactions 2.138E-5 5.656E-4 3.631E-3 7.353E-3 2 16
14 int:CSE1L CSE1L interactions 2.865E-5 7.039E-4 4.519E-3 9.855E-3 3 144
15 int:PPFIA2 PPFIA2 interactions 4.500E-5 1.032E-3 6.624E-3 1.548E-2 2 23
16 int:PPFIA3 PPFIA3 interactions 5.333E-5 1.147E-3 7.361E-3 1.835E-2 2 25
17 int:C19orf25 C19orf25 interactions 7.724E-5 1.563E-3 1.003E-2 2.657E-2 2 30
18 int:IL2RG IL2RG interactions 1.117E-4 2.135E-3 1.371E-2 3.843E-2 2 36
19 int:TRIO TRIO interactions 1.525E-4 2.761E-3 1.772E-2
5.245E-2
 2 42
20 int:CANX CANX interactions 1.877E-4 3.132E-3 2.011E-2
6.457E-2
 3 271
21 int:XPO6 XPO6 interactions 1.912E-4 3.132E-3 2.011E-2
6.578E-2
 2 47
22 int:TPCN2 TPCN2 interactions 2.527E-4 3.952E-3 2.537E-2
8.694E-2
 2 54
23 int:NCDN NCDN interactions 2.817E-4 4.213E-3 2.704E-2
9.690E-2
 2 57
24 int:BZW2 BZW2 interactions 3.778E-4 5.415E-3 3.476E-2
1.300E-1
 2 66
25 int:PRKCSH PRKCSH interactions 4.129E-4 5.682E-3 3.647E-2
1.420E-1
 2 69
26 int:PPFIA1 PPFIA1 interactions 4.372E-4 5.784E-3 3.713E-2
1.504E-1
 2 71
27 int:XPO5 XPO5 interactions 5.687E-4 7.246E-3 4.651E-2
1.956E-1
 2 81
28 int:BAIAP2 BAIAP2 interactions 6.115E-4 7.513E-3 4.823E-2
2.104E-1
 2 84
29 int:TXNDC5 TXNDC5 interactions 6.709E-4 7.958E-3
5.109E-2
2.308E-1
 2 88
30 int:PTPRN PTPRN interactions 7.016E-4 8.045E-3
5.164E-2
2.413E-1
 2 90
31 int:RYK RYK interactions 7.330E-4 8.133E-3
5.221E-2
2.521E-1
 2 92
32 int:RINT1 RINT1 interactions 7.977E-4 8.576E-3
5.505E-2
2.744E-1
 2 96
33 int:PTN PTN interactions 8.652E-4 9.019E-3
5.789E-2
2.976E-1
 2 100
34 int:CERS3 CERS3 interactions 9.036E-4 9.143E-3
5.869E-2
3.108E-1
 1 2
35 int:LGALS8 LGALS8 interactions 1.162E-3 1.142E-2
7.329E-2
3.996E-1
 2 116
36 int:PDIA6 PDIA6 interactions 1.202E-3 1.148E-2
7.371E-2
4.134E-1
 2 118
37 int:GANAB GANAB interactions 1.263E-3 1.174E-2
7.537E-2
4.344E-1
 2 121
38 int:PLA2G7 PLA2G7 interactions 1.355E-3 1.195E-2
7.673E-2
4.662E-1
 1 3
39 int:ST13P4 ST13P4 interactions 1.355E-3 1.195E-2
7.673E-2
4.662E-1
 1 3
40 int:IPO5 IPO5 interactions 1.434E-3 1.233E-2
7.914E-2
4.931E-1
 2 129
41 int:ASNSD1 ASNSD1 interactions 1.807E-3 1.445E-2
9.277E-2
6.214E-1
 1 4
42 int:TMC1 TMC1 interactions 1.807E-3 1.445E-2
9.277E-2
6.214E-1
 1 4
43 int:GPRIN3 GPRIN3 interactions 1.807E-3 1.445E-2
9.277E-2
6.214E-1
 1 4
44 int:LRRN1 LRRN1 interactions 2.258E-3 1.765E-2
1.133E-1
7.767E-1
 1 5
45 int:CYB561 CYB561 interactions 3.160E-3 2.363E-2
1.517E-1
1.000E0
 1 7
46 int:MICAL2 MICAL2 interactions 3.160E-3 2.363E-2
1.517E-1
1.000E0
 1 7
47 int:LGALS3 LGALS3 interactions 3.501E-3 2.388E-2
1.533E-1
1.000E0
 2 203
48 int:MILR1 MILR1 interactions 3.610E-3 2.388E-2
1.533E-1
1.000E0
 1 8
49 int:SNX19 SNX19 interactions 3.610E-3 2.388E-2
1.533E-1
1.000E0
 1 8
50 int:ICOSLG ICOSLG interactions 3.610E-3 2.388E-2
1.533E-1
1.000E0
 1 8
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q35-q36.1 2q35-q36.1 2.308E-4 9.232E-4 2.509E-3 1.846E-3 1 1
2 9p23-p24.3 9p23-p24.3 2.308E-4 9.232E-4 2.509E-3 1.846E-3 1 1
3 7q31.3 7q31.3 3.457E-3 9.219E-3 2.506E-2 2.766E-2 1 15
4 10q26 10q26 5.297E-3 1.059E-2 2.879E-2 4.237E-2 1 23
5 12q15 12q15 7.592E-3 1.215E-2 3.301E-2
6.074E-2
 1 33
6 11p11.2 11p11.2 2.013E-2 2.663E-2
7.238E-2
1.611E-1
 1 88
7 20p13 20p13 2.330E-2 2.663E-2
7.238E-2
1.864E-1
 1 102
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 8 input genes in category / 68 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 8 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 813 Fibronectin type III domain containing|Protein tyrosine phosphatases, receptor type genenames.org 6.844E-25 2.738E-24 5.703E-24 2.738E-24 8 21
2 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 3.923E-7 7.847E-7 1.635E-6 1.569E-6 4 160
3 593 Fibronectin type III domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 2.104E-3 2.805E-3 5.845E-3 8.416E-3 2 161

13: Coexpression [Display Chart] 8 input genes in category / 967 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15665281-Table2 Human Brain Wong05 96genes GeneSigDB 1.286E-6 1.244E-3 9.269E-3 1.244E-3 3 67
2 17823238-TableS5 Human EmbryonicStemCell Soh07 469genes GeneSigDB 1.031E-5 4.984E-3 3.714E-2 9.968E-3 4 462
3 M3781 Genes down-regulated in comparison of control dendritic cells (DC) at 4 h versus those stimulated with Gardiquimod (TLR7 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 3.451E-5 1.112E-2
8.290E-2
 3.337E-2 3 200
4 17363501-Table2 Human pancreas Jimeno07 39genes GeneSigDB 6.552E-5 1.339E-2
9.981E-2
6.336E-2
 2 36
5 M12802 Genes from the recurrent amplicons in 89 samples of oral squamous cell carcinoma (SCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 6.925E-5 1.339E-2
9.981E-2
6.697E-2
 2 37
6 M15476 Genes up-regulated in primary adipocytes compared to preadipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.791E-4 3.741E-2
2.788E-1
2.699E-1
 2 74
7 16024625-Table1 Human Colon Craene05 85genes GeneSigDB 2.791E-4 3.741E-2
2.788E-1
2.699E-1
 2 74
8 16488994-SuppTable1b Mouse Lung Lu06 856genes Array MEO430Av2 GeneSigDB 3.635E-4 3.741E-2
2.788E-1
3.515E-1
 3 443
9 16488994-SuppTable1a Mouse Lung Lu06 856genes Array MG U74Av2 GeneSigDB 3.781E-4 3.741E-2
2.788E-1
3.656E-1
 3 449
10 12917485-Table6 Human Breast Sotiriou03 606genes ER GeneSigDB 3.931E-4 3.741E-2
2.788E-1
3.801E-1
 3 455
11 M15382 Genes up-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 10 h time point that were not up-regulated at the previous time point, 8 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.091E-4 3.741E-2
2.788E-1
4.923E-1
 2 100
12 M4925 Up-regulated genes classifying non-tumor lung tissues by age after incution of lung cancer by urethane injection [PubChem=5641]: early (24-26 weeks) vs late (46 weeks). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.937E-4 3.741E-2
2.788E-1
7.675E-1
 2 125
13 16024625-SuppTable2a Human Colon Craene05 185genes GeneSigDB 8.064E-4 3.741E-2
2.788E-1
7.797E-1
 2 126
14 11988840-Table1 Human Breast Oh02 170genes GeneSigDB 9.112E-4 3.741E-2
2.788E-1
8.811E-1
 2 134
15 M9446 Genes up-regulated in splenocytes: control versus infected with Sendai virus. MSigDB C7: Immunologic Signatures (v6.0) 1.263E-3 3.741E-2
2.788E-1
1.000E0
 2 158
16 M8242 Genes down-regulated in polarizing CD4 [GeneID=920] Th17 cells: wildtype versus RORC [GeneID=6097] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.409E-3 3.741E-2
2.788E-1
1.000E0
 2 167
17 M6323 Genes up-regulated in spleen from DUSP1 [GeneID=1843] knockout: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.563E-3 3.741E-2
2.788E-1
1.000E0
 2 176
18 M7008 Genes up-regulated in megakaryo-erythrocyte progenitors versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.599E-3 3.741E-2
2.788E-1
1.000E0
 2 178
19 M2787 Genes up-regulated upon knockdown of PTEN [Gene ID=5728] by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.799E-3 3.741E-2
2.788E-1
1.000E0
 2 189
20 M2675 Genes down-regulated in HUVEC cells (endothelium) by treatment with VEGFA [Gene ID=7422]. MSigDB C6: Oncogenic Signatures (v6.0) 1.875E-3 3.741E-2
2.788E-1
1.000E0
 2 193
21 M8287 Genes up-regulated in B lymphocytes from: peritoneal cavity versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 1.914E-3 3.741E-2
2.788E-1
1.000E0
 2 195
22 M4959 Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 post-vaccination versus plasmacytoid dendritic cells (pDC) at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.741E-2
2.788E-1
1.000E0
 2 199
23 M8361 Genes up-regulated in T reg: natural versus induced cells. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.741E-2
2.788E-1
1.000E0
 2 199
24 M4374 Genes up-regulated in comparison of lung tissue from wild type mice subjected to ozone for 0 h versus that from TLR4 [GeneID=7099] deficient mice subjected to ozone for 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.741E-2
2.788E-1
1.000E0
 2 199
25 M4942 Genes down-regulated in comparison of B cells versus plasmacytoid dendritic cells (pDC) . MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 3.741E-2
2.788E-1
1.000E0
 2 199
26 M8357 Genes up-regulated in atherosclerosis macrophages: anti miR-33 versus anti miR. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
27 M3217 Genes up-regulated in comparison of CD4 [GeneID=920] T cells activated with lamina propria dendritic cells versus regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
28 M3760 Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with CpG DNA (TLR9 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
29 M8367 Genes down-regulated in T reg from: peripheral blood versus cord blood. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
30 M6609 Genes up-regulated in bone marrow-derived macrophage (45 min): LPS versus IL10 [GeneID=3586] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
31 M8468 Genes up-regulated in activated CD4 [GeneID=920] T cells with MIR17 [GeneID=406952] perturbation: knockout versus over-expression. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
32 M9662 Genes down-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 20h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
33 M9076 Genes up-regulated in memory CD8 T cells: ITGAE- [GeneID=3682] from spleen versus ITGAE+ [GeneID=3682] from brain. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
34 M8982 Genes down-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 form of PPARG [GeneID=5468]: untreated versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
35 M5838 Genes up-regulated in comparison of exhausted CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
36 M4895 Genes up-regulated in comparison of primary splenic B cells from wild type mice versus those from Xid mice. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
37 M3688 Genes down-regulated in comparison of control dendritic cells (DC) at 2 h versus those stimulated with LPS (TLR4 agonist) at 2 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
38 M3629 Genes up-regulated in comparison of unstimulated CD8 T cells at 48 h versus CD8 T cells at 48 h after stimulation with IL12. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
39 M3823 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
40 M6655 Genes up-regulated in bone marrow-derived macrophages at 45 min of stimulation by IL10 [GeneID=3486] and LPS: IL6 [GeneID=3469] knockout versus IL10 [GeneID=3486] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
41 M3957 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
42 M3869 Genes up-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 16 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
43 M8764 Genes up-regulated in monocytes: CD16- versus CD16+. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
44 M4978 Genes up-regulated in comparison of plasmacytoid dendritic cells (pDC) from influenza vaccinee pre-vaccination versus those at day 7 post-vaccination. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
45 M4094 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus those stimulated at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
46 M8985 Genes up-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943] and PPARg1 isoform of PPARG [GeneID=5468]: GW1929 [PubChem=6518171] versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
47 M6620 Genes up-regulated in bone marrow-derived macrophages with IL6 [GeneID=3569] knockout and 45 min of stimulation by: LPS versus IL6 [GeneID=3569] and LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
48 M3749 Genes up-regulated in comparison of control dendritic cells (DC) at 12 h versus those stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
49 M8635 Genes down-regulated in bone marrow-derived dendritic cells treated with 1,3-beta-D-oligoglucan [PubChem=11375554]: low dose versus high dose. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
50 M8470 Genes down-regulated in activated CD4 [GeneID=920] T cells with MIR17 [GeneID=406952] perturbation: knockout versus over-expression. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 3.741E-2
2.788E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 871 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 JC iEC 2500 K2 JC iEC top-relative-expression-ranked 2500 k-means-cluster#2 PCBC 2.918E-6 2.541E-3 1.867E-2 2.541E-3 4 317
2 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Testicular Germ Cell Tumor/3/3 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Testicular Germ Cell Tumor/3/3 TCGA-Testes 1.569E-5 6.833E-3
5.020E-2
 1.367E-2 3 145
3 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte precursor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Brain Non-Myeloid/oligodendrocyte precursor cell Tabula Muris Consortium 3.575E-5 1.038E-2
7.627E-2
 3.114E-2 3 191
4 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr GlobusPallidus Top 200 Genes BrainMap 1.780E-4 3.876E-2
2.848E-1
1.550E-1
 3 328

15: Computational [Display Chart] 8 input genes in category / 68 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9347 MODULE 176 Signaling. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.108E-4 2.971E-2
1.427E-1
 4.154E-2 3 230
2 M16447 MODULE 112 Genes in the cancer module 112. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.737E-4 2.971E-2
1.427E-1
5.941E-2
 3 260
3 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.152E-3 4.878E-2
2.343E-1
1.463E-1
 3 355

16: MicroRNA [Display Chart] 8 input genes in category / 361 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-34b:PITA hsa-miR-34b:PITA TOP PITA 5.134E-8 1.853E-5 1.199E-4 1.853E-5 4 379
2 hsa-miR-34c-3p:PITA hsa-miR-34c-3p:PITA TOP PITA 1.929E-6 3.482E-4 2.252E-3 6.963E-4 3 237
3 hsa-miR-139-5p:TargetScan hsa-miR-139-5p TargetScan 4.525E-6 5.445E-4 3.521E-3 1.633E-3 3 315
4 hsa-miR-521:mirSVR lowEffct hsa-miR-521:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.441E-6 6.716E-4 4.343E-3 2.686E-3 3 372
5 hsa-miR-542-5p:mirSVR lowEffct hsa-miR-542-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.439E-5 1.039E-3 6.721E-3 5.196E-3 3 464
6 hsa-miR-362-5p:PITA hsa-miR-362-5p:PITA TOP PITA 9.778E-5 5.117E-3 3.309E-2 3.530E-2 2 136
7 hsa-miR-455-5p:PITA hsa-miR-455-5p:PITA TOP PITA 9.922E-5 5.117E-3 3.309E-2 3.582E-2 2 137
8 hsa-miR-1228:PITA hsa-miR-1228:PITA TOP PITA 1.731E-4 6.611E-3 4.276E-2
6.248E-2
 2 181
9 hsa-miR-455-5p:TargetScan hsa-miR-455-5p TargetScan 1.827E-4 6.611E-3 4.276E-2
6.597E-2
 2 186
10 hsa-miR-876-5p:PITA hsa-miR-876-5p:PITA TOP PITA 2.070E-4 6.611E-3 4.276E-2
7.473E-2
 2 198
11 hsa-miR-573:PITA hsa-miR-573:PITA TOP PITA 2.417E-4 6.611E-3 4.276E-2
8.726E-2
 2 214
12 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 2.417E-4 6.611E-3 4.276E-2
8.726E-2
 2 214
13 hsa-miR-876-5p:TargetScan hsa-miR-876-5p TargetScan 2.766E-4 6.611E-3 4.276E-2
9.986E-2
 2 229
14 hsa-miR-1261:PITA hsa-miR-1261:PITA TOP PITA 2.839E-4 6.611E-3 4.276E-2
1.025E-1
 2 232
15 hsa-miR-569:PITA hsa-miR-569:PITA TOP PITA 3.088E-4 6.611E-3 4.276E-2
1.115E-1
 2 242
16 hsa-miR-133b:PITA hsa-miR-133b:PITA TOP PITA 3.113E-4 6.611E-3 4.276E-2
1.124E-1
 2 243
17 hsa-miR-133a:PITA hsa-miR-133a:PITA TOP PITA 3.113E-4 6.611E-3 4.276E-2
1.124E-1
 2 243
18 hsa-miR-1244:PITA hsa-miR-1244:PITA TOP PITA 3.616E-4 6.981E-3 4.515E-2
1.306E-1
 2 262
19 hsa-miR-891b:PITA hsa-miR-891b:PITA TOP PITA 3.783E-4 6.981E-3 4.515E-2
1.366E-1
 2 268
20 hsa-miR-194:PITA hsa-miR-194:PITA TOP PITA 3.868E-4 6.981E-3 4.515E-2
1.396E-1
 2 271
21 hsa-miR-935:PITA hsa-miR-935:PITA TOP PITA 4.186E-4 7.196E-3 4.654E-2
1.511E-1
 2 282
22 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 4.924E-4 8.013E-3
5.183E-2
1.778E-1
 2 306
23 hsa-miR-515-5p:PITA hsa-miR-515-5p:PITA TOP PITA 5.282E-4 8.013E-3
5.183E-2
1.907E-1
 2 317
24 hsa-miR-139-5p:PITA hsa-miR-139-5p:PITA TOP PITA 5.348E-4 8.013E-3
5.183E-2
1.931E-1
 2 319
25 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 5.549E-4 8.013E-3
5.183E-2
2.003E-1
 2 325
26 hsa-miR-324-5p:mirSVR highEffct hsa-miR-324-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 6.502E-4 9.027E-3
5.838E-2
2.347E-1
 2 352
27 hsa-miR-603:PITA hsa-miR-603:PITA TOP PITA 7.766E-4 9.297E-3
6.013E-2
2.803E-1
 2 385
28 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 7.846E-4 9.297E-3
6.013E-2
2.832E-1
 2 387
29 hsa-miR-4292:mirSVR highEffct hsa-miR-4292:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.335E-4 9.297E-3
6.013E-2
3.009E-1
 2 399
30 hsa-miR-133a-3p.1:TargetScan hsa-miR-133a-3p.1 TargetScan 8.967E-4 9.297E-3
6.013E-2
3.237E-1
 2 414
31 hsa-miR-205-5p:TargetScan hsa-miR-205-5p TargetScan 9.182E-4 9.297E-3
6.013E-2
3.315E-1
 2 419
32 hsa-miR-204:PITA hsa-miR-204:PITA TOP PITA 9.710E-4 9.297E-3
6.013E-2
3.505E-1
 2 431
33 hsa-miR-211:PITA hsa-miR-211:PITA TOP PITA 9.710E-4 9.297E-3
6.013E-2
3.505E-1
 2 431
34 hsa-miR-105:PITA hsa-miR-105:PITA TOP PITA 9.799E-4 9.297E-3
6.013E-2
3.538E-1
 2 433
35 hsa-miR-448:PITA hsa-miR-448:PITA TOP PITA 1.002E-3 9.297E-3
6.013E-2
3.619E-1
 2 438
36 hsa-miR-452:PITA hsa-miR-452:PITA TOP PITA 1.062E-3 9.297E-3
6.013E-2
3.834E-1
 2 451
37 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 1.067E-3 9.297E-3
6.013E-2
3.851E-1
 2 452
38 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 1.071E-3 9.297E-3
6.013E-2
3.868E-1
 2 453
39 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 1.090E-3 9.297E-3
6.013E-2
3.936E-1
 2 457
40 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 1.201E-3 9.297E-3
6.013E-2
4.337E-1
 2 480
41 hsa-miR-181c*:mirSVR lowEffct hsa-miR-181c*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.216E-3 9.297E-3
6.013E-2
4.391E-1
 2 483
42 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 1.231E-3 9.297E-3
6.013E-2
4.445E-1
 2 486
43 hsa-miR-133b:TargetScan hsa-miR-133b TargetScan 1.236E-3 9.297E-3
6.013E-2
4.463E-1
 2 487
44 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 1.236E-3 9.297E-3
6.013E-2
4.463E-1
 2 487
45 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 1.236E-3 9.297E-3
6.013E-2
4.463E-1
 2 487
46 hsa-miR-133a-3p.2:TargetScan hsa-miR-133a-3p.2 TargetScan 1.236E-3 9.297E-3
6.013E-2
4.463E-1
 2 487
47 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 1.236E-3 9.297E-3
6.013E-2
4.463E-1
 2 487
48 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 1.236E-3 9.297E-3
6.013E-2
4.463E-1
 2 487
49 hsa-miR-1281:PITA hsa-miR-1281:PITA TOP PITA 1.992E-3 1.438E-2
9.300E-2
7.190E-1
 1 18
50 hsa-miR-941:PITA hsa-miR-941:PITA TOP PITA 1.992E-3 1.438E-2
9.300E-2
7.190E-1
 1 18
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 1727 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C405943 2-(oxalylamino)benzoic acid CTD 2.252E-6 3.890E-3 3.124E-2 3.890E-3 2 7
2 CID000000378 p-nitrophenyl phosphate Stitch 3.274E-5 1.220E-2
9.799E-2
5.655E-2
 3 194
3 5862 UP Repaglinide [135062-02-1]; Up 200; 8.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.480E-5 1.220E-2
9.799E-2
6.010E-2
 3 198
4 434 UP sodium 4-phenylbutyrate; Up 200; 1000uM; PC3; HG-U133A Broad Institute CMAP Up 3.480E-5 1.220E-2
9.799E-2
6.010E-2
 3 198
5 4213 UP Austricine [10180-88-8]; Up 200; 14.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.532E-5 1.220E-2
9.799E-2
6.101E-2
 3 199
6 CID000003305 etidronate Stitch 5.296E-5 1.524E-2
1.224E-1
9.147E-2
 2 32
7 CID000061671 vanadyl Stitch 1.281E-4 3.160E-2
2.538E-1
2.212E-1
 3 307
8 CID000336564 NSC-351324 Stitch 1.522E-4 3.286E-2
2.639E-1
2.629E-1
 2 54
9 CID000040024 deoxynivalenol Stitch 2.074E-4 3.980E-2
3.197E-1
3.582E-1
 2 63
10 CID000129650 AC1Q6MUY Stitch 3.502E-4 4.900E-2
3.936E-1
6.049E-1
 1 1
11 CID000009837 F 222 Stitch 3.502E-4 4.900E-2
3.936E-1
6.049E-1
 1 1
12 CID000121858 hydroxymetronidazole Stitch 3.502E-4 4.900E-2
3.936E-1
6.049E-1
 1 1
13 CID000065099 lucigenin Stitch 3.689E-4 4.900E-2
3.936E-1
6.370E-1
 2 84
14 CID000002088 alendronate Stitch 4.233E-4 4.901E-2
3.936E-1
7.311E-1
 2 90
15 CID000104978 fluo-3 Stitch 7.758E-4 4.901E-2
3.936E-1
1.000E0
 2 122
16 CID006914639 AC1OCADI Stitch 8.801E-4 4.901E-2
3.936E-1
1.000E0
 2 130
17 CID000009731 4-fluoroaniline Stitch 1.400E-3 4.901E-2
3.936E-1
1.000E0
 1 4
18 CID000101359 Haloperidol metabolite III Stitch 1.400E-3 4.901E-2
3.936E-1
1.000E0
 1 4
19 6427 UP STOCK1N-35215; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.713E-3 4.901E-2
3.936E-1
1.000E0
 2 182
20 ctd:D001427 Bacterial Toxins CTD 1.750E-3 4.901E-2
3.936E-1
1.000E0
 1 5
21 ctd:D017261 Glycosylphosphatidylinositols CTD 1.750E-3 4.901E-2
3.936E-1
1.000E0
 1 5
22 CID000194903 Dtpc Stitch 1.750E-3 4.901E-2
3.936E-1
1.000E0
 1 5
23 5675 UP Colchicine [64-86-8]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.846E-3 4.901E-2
3.936E-1
1.000E0
 2 189
24 611 UP geldanamycin; Up 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Up 1.846E-3 4.901E-2
3.936E-1
1.000E0
 2 189
25 4322 DN Sulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.865E-3 4.901E-2
3.936E-1
1.000E0
 2 190
26 7547 UP Ald1.1-H 000455; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.884E-3 4.901E-2
3.936E-1
1.000E0
 2 191
27 7392 UP 0175029-0000 [211245-78-2]; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.923E-3 4.901E-2
3.936E-1
1.000E0
 2 193
28 6938 UP radicicol, diheterospora chlamydosporia; Up 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.923E-3 4.901E-2
3.936E-1
1.000E0
 2 193
29 6613 DN Theobromine [83-67-0]; Down 200; 22.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.943E-3 4.901E-2
3.936E-1
1.000E0
 2 194
30 3570 DN 2-Chloropyrazine [14508-49-7]; Down 200; 35uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.943E-3 4.901E-2
3.936E-1
1.000E0
 2 194
31 4298 UP 3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.963E-3 4.901E-2
3.936E-1
1.000E0
 2 195
32 1015 UP genistein; Up 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 1.963E-3 4.901E-2
3.936E-1
1.000E0
 2 195
33 3977 DN Fludrocortisone acetate [514-36-3]; Down 200; 9.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.963E-3 4.901E-2
3.936E-1
1.000E0
 2 195
34 7025 UP Clorsulon [60200-06-8]; Up 200; 10.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
35 167 DN amitriptyline hydrochloride; Down 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Down 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
36 4629 DN Droperidol [548-73-2]; Down 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
37 2121 DN Mefexamide hydrochloride [3413-64-7]; Down 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
38 5533 UP (-)-Adenosine 3',5'-cyclic monophosphate [60-92-4]; Up 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
39 4825 UP Amprolium hydrochloride [137-88-2]; Up 200; 12.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
40 7131 UP Ronidazole [7681-76-7]; Up 200; 20uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
41 5758 UP Phenazopyridine hydrochloride [136-40-3]; Up 200; 16uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.983E-3 4.901E-2
3.936E-1
1.000E0
 2 196
42 3042 DN Carbachol [51-83-2]; Down 200; 21.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
43 5809 UP Natamycin [7681-93-8]; Up 200; 6uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
44 7345 DN Alcuronium chloride [15180-03-7]; Down 200; 5.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
45 3829 DN Mepenzolate bromide [76-90-4]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
46 4803 UP Scopolamine hydrochloride [55-16-3]; Up 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
47 2698 DN ICI 182,780; Down 200; 0.01uM; HL60; HT HG-U133A Broad Institute CMAP Down 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
48 7061 DN SB 203580; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.003E-3 4.901E-2
3.936E-1
1.000E0
 2 197
49 4489 UP Hydrocotarnine hydrobromide [5985-00-2]; Up 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.023E-3 4.901E-2
3.936E-1
1.000E0
 2 198
50 4225 UP Carcinine [56897-53-1]; Up 200; 22uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.023E-3 4.901E-2
3.936E-1
1.000E0
 2 198
Show 45 more annotations

18: Disease [Display Chart] 8 input genes in category / 79 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20081125:Schormair Restless legs syndrome GWAS 4.937E-4 1.300E-2
6.439E-2
 3.900E-2 1 1
2 C0796548 Metastatic tumors of the Ewing's family DisGeNET BeFree 4.937E-4 1.300E-2
6.439E-2
 3.900E-2 1 1
3 C0278586 Metastatic Ewing's Sarcoma DisGeNET BeFree 4.937E-4 1.300E-2
6.439E-2
 3.900E-2 1 1
4 cv:C1838332 Helicobacter pylori infection, susceptibility to Clinical Variations 9.871E-4 1.560E-2
7.725E-2
7.798E-2
 1 2
5 OMIN:600263 HELICOBACTER PYLORI INFECTION, SUSCEPTIBILITY TO OMIM 9.871E-4 1.560E-2
7.725E-2
7.798E-2
 1 2
6 C1322252 Chordoid Glioma of the Third Ventricle DisGeNET BeFree 1.480E-3 1.949E-2
9.654E-2
1.170E-1
 1 3
7 C0334296 Solid carcinoma DisGeNET BeFree 1.973E-3 2.227E-2
1.103E-1
1.559E-1
 1 4
8 C0476122 ovarian serous tumor DisGeNET BeFree 2.959E-3 2.922E-2
1.447E-1
2.337E-1
 1 6
9 20081125:Benjamin Select biomarker traits GWAS 5.419E-3 4.281E-2
2.120E-1
4.281E-1
 1 11
10 C0079487 Helicobacter Infections DisGeNET Curated 5.419E-3 4.281E-2
2.120E-1
4.281E-1
 1 11
11 C1863051 ALZHEIMER DISEASE 2 DisGeNET Curated 6.892E-3 4.950E-2
2.452E-1
5.445E-1
 1 14
Show 6 more annotations