Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc139_46, positive side

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1: GO: Molecular Function [Display Chart] 46 input genes in category / 148 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030332 cyclin binding 2.368E-9 2.985E-7 1.665E-6 3.504E-7 5 23
2 GO:0003688 DNA replication origin binding 4.034E-9 2.985E-7 1.665E-6 5.970E-7 4 9
3 GO:0004693 cyclin-dependent protein serine/threonine kinase activity 2.235E-8 7.667E-7 4.277E-6 3.307E-6 5 35
4 GO:0097472 cyclin-dependent protein kinase activity 2.235E-8 7.667E-7 4.277E-6 3.307E-6 5 35
5 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity 2.590E-8 7.667E-7 4.277E-6 3.834E-6 5 36
6 GO:0004674 protein serine/threonine kinase activity 1.175E-7 2.899E-6 1.617E-5 1.739E-5 10 452
7 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 4.888E-6 1.033E-4 5.764E-4 7.234E-4 4 46
8 GO:0035173 histone kinase activity 1.321E-5 2.444E-4 1.363E-3 1.956E-3 3 19
9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 3.104E-5 5.104E-4 2.847E-3 4.594E-3 3 25
10 GO:0019887 protein kinase regulator activity 1.146E-4 1.696E-3 9.459E-3 1.696E-2 5 195
11 GO:0019207 kinase regulator activity 1.848E-4 2.486E-3 1.387E-2 2.735E-2 5 216
12 GO:0061134 peptidase regulator activity 2.099E-4 2.589E-3 1.444E-2 3.106E-2 5 222
13 GO:0004857 enzyme inhibitor activity 3.859E-4 3.881E-3 2.165E-2
5.712E-2
 6 393
14 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity 3.862E-4 3.881E-3 2.165E-2
5.716E-2
 2 12
15 GO:0004869 cysteine-type endopeptidase inhibitor activity 3.934E-4 3.881E-3 2.165E-2
5.822E-2
 3 58
16 GO:0000287 magnesium ion binding 1.638E-3 1.515E-2
8.449E-2
2.424E-1
 4 206
17 GO:0035800 deubiquitinase activator activity 2.465E-3 1.831E-2
1.021E-1
3.648E-1
 1 1
18 GO:0042083 5,10-methylenetetrahydrofolate-dependent methyltransferase activity 2.465E-3 1.831E-2
1.021E-1
3.648E-1
 1 1
19 GO:0004799 thymidylate synthase activity 2.465E-3 1.831E-2
1.021E-1
3.648E-1
 1 1
20 GO:0030291 protein serine/threonine kinase inhibitor activity 2.475E-3 1.831E-2
1.021E-1
3.663E-1
 2 30
21 GO:0030544 Hsp70 protein binding 3.172E-3 2.235E-2
1.247E-1
4.694E-1
 2 34
22 GO:0004842 ubiquitin-protein transferase activity 3.405E-3 2.290E-2
1.278E-1
5.039E-1
 5 414
23 GO:0019787 ubiquitin-like protein transferase activity 4.452E-3 2.759E-2
1.539E-1
6.589E-1
 5 441
24 GO:0050681 androgen receptor binding 4.585E-3 2.759E-2
1.539E-1
6.786E-1
 2 41
25 GO:0061752 telomeric repeat-containing RNA binding 4.924E-3 2.759E-2
1.539E-1
7.288E-1
 1 2
26 GO:0004797 thymidine kinase activity 4.924E-3 2.759E-2
1.539E-1
7.288E-1
 1 2
27 GO:0016504 peptidase activator activity 5.034E-3 2.759E-2
1.539E-1
7.450E-1
 2 43
28 GO:0030145 manganese ion binding 7.019E-3 3.639E-2
2.030E-1
1.000E0
 2 51
29 GO:0035257 nuclear hormone receptor binding 7.293E-3 3.639E-2
2.030E-1
1.000E0
 3 161
30 GO:0035175 histone kinase activity (H3-S10 specific) 7.377E-3 3.639E-2
2.030E-1
1.000E0
 1 3
31 GO:0004866 endopeptidase inhibitor activity 8.599E-3 4.064E-2
2.267E-1
1.000E0
 3 171
32 GO:0061135 endopeptidase regulator activity 9.445E-3 4.064E-2
2.267E-1
1.000E0
 3 177
33 GO:0070491 repressing transcription factor binding 9.608E-3 4.064E-2
2.267E-1
1.000E0
 2 60
34 GO:1904288 BAT3 complex binding 9.825E-3 4.064E-2
2.267E-1
1.000E0
 1 4
35 GO:0019136 deoxynucleoside kinase activity 9.825E-3 4.064E-2
2.267E-1
1.000E0
 1 4
36 GO:0030414 peptidase inhibitor activity 9.885E-3 4.064E-2
2.267E-1
1.000E0
 3 180
37 GO:0051427 hormone receptor binding 1.034E-2 4.135E-2
2.306E-1
1.000E0
 3 183
38 GO:0004721 phosphoprotein phosphatase activity 1.177E-2 4.583E-2
2.556E-1
1.000E0
 3 192
Show 33 more annotations

2: GO: Biological Process [Display Chart] 46 input genes in category / 1277 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000082 G1/S transition of mitotic cell cycle 5.382E-26 6.873E-23 5.313E-22 6.873E-23 20 247
2 GO:0044843 cell cycle G1/S phase transition 1.212E-25 7.739E-23 5.982E-22 1.548E-22 20 257
3 GO:1901990 regulation of mitotic cell cycle phase transition 6.990E-16 2.975E-13 2.300E-12 8.926E-13 15 318
4 GO:0000086 G2/M transition of mitotic cell cycle 1.045E-15 3.335E-13 2.578E-12 1.334E-12 13 197
5 GO:1901987 regulation of cell cycle phase transition 1.725E-15 3.741E-13 2.891E-12 2.203E-12 15 338
6 GO:0044839 cell cycle G2/M phase transition 1.758E-15 3.741E-13 2.891E-12 2.244E-12 13 205
7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity 1.358E-12 2.348E-10 1.815E-9 1.734E-9 9 94
8 GO:0006260 DNA replication 1.471E-12 2.348E-10 1.815E-9 1.879E-9 13 346
9 GO:1904029 regulation of cyclin-dependent protein kinase activity 2.190E-12 3.107E-10 2.402E-9 2.797E-9 9 99
10 GO:0031570 DNA integrity checkpoint 6.603E-12 8.432E-10 6.517E-9 8.432E-9 10 164
11 GO:0000075 cell cycle checkpoint 8.828E-12 1.025E-9 7.922E-9 1.127E-8 11 234
12 GO:0045787 positive regulation of cell cycle 3.770E-11 4.011E-9 3.101E-8 4.814E-8 12 352
13 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle 4.608E-11 4.526E-9 3.499E-8 5.884E-8 6 27
14 GO:2000045 regulation of G1/S transition of mitotic cell cycle 7.510E-11 6.850E-9 5.295E-8 9.591E-8 9 146
15 GO:0044773 mitotic DNA damage checkpoint 1.243E-10 1.058E-8 8.179E-8 1.587E-7 8 101
16 GO:1902806 regulation of cell cycle G1/S phase transition 1.361E-10 1.086E-8 8.398E-8 1.738E-7 9 156
17 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 1.545E-10 1.092E-8 8.440E-8 1.974E-7 7 62
18 GO:0072431 signal transduction involved in mitotic G1 DNA damage checkpoint 1.735E-10 1.092E-8 8.440E-8 2.216E-7 7 63
19 GO:1902400 intracellular signal transduction involved in G1 DNA damage checkpoint 1.735E-10 1.092E-8 8.440E-8 2.216E-7 7 63
20 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint 1.945E-10 1.092E-8 8.440E-8 2.484E-7 7 64
21 GO:1902403 signal transduction involved in mitotic DNA integrity checkpoint 1.945E-10 1.092E-8 8.440E-8 2.484E-7 7 64
22 GO:1902402 signal transduction involved in mitotic DNA damage checkpoint 1.945E-10 1.092E-8 8.440E-8 2.484E-7 7 64
23 GO:0044774 mitotic DNA integrity checkpoint 1.983E-10 1.092E-8 8.440E-8 2.532E-7 8 107
24 GO:0030330 DNA damage response, signal transduction by p53 class mediator 2.137E-10 1.092E-8 8.440E-8 2.730E-7 8 108
25 GO:0071156 regulation of cell cycle arrest 2.137E-10 1.092E-8 8.440E-8 2.730E-7 8 108
26 GO:0072401 signal transduction involved in DNA integrity checkpoint 2.429E-10 1.135E-8 8.777E-8 3.102E-7 7 66
27 GO:0072422 signal transduction involved in DNA damage checkpoint 2.429E-10 1.135E-8 8.777E-8 3.102E-7 7 66
28 GO:0006270 DNA replication initiation 2.490E-10 1.135E-8 8.777E-8 3.179E-7 6 35
29 GO:0072395 signal transduction involved in cell cycle checkpoint 2.708E-10 1.192E-8 9.217E-8 3.458E-7 7 67
30 GO:0044819 mitotic G1/S transition checkpoint 5.018E-10 2.067E-8 1.598E-7 6.408E-7 7 73
31 GO:0031571 mitotic G1 DNA damage checkpoint 5.018E-10 2.067E-8 1.598E-7 6.408E-7 7 73
32 GO:0044783 G1 DNA damage checkpoint 5.532E-10 2.206E-8 1.705E-7 7.064E-7 7 74
33 GO:0042770 signal transduction in response to DNA damage 5.699E-10 2.206E-8 1.705E-7 7.278E-7 8 122
34 GO:0090068 positive regulation of cell cycle process 5.975E-10 2.244E-8 1.735E-7 7.630E-7 10 259
35 GO:0071158 positive regulation of cell cycle arrest 1.487E-9 5.425E-8 4.194E-7 1.899E-6 7 85
36 GO:0000077 DNA damage checkpoint 3.642E-9 1.292E-7 9.985E-7 4.650E-6 8 154
37 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle 4.069E-9 1.404E-7 1.086E-6 5.196E-6 7 98
38 GO:1901991 negative regulation of mitotic cell cycle phase transition 4.687E-9 1.575E-7 1.218E-6 5.986E-6 8 159
39 GO:1902807 negative regulation of cell cycle G1/S phase transition 5.031E-9 1.647E-7 1.273E-6 6.425E-6 7 101
40 GO:0007093 mitotic cell cycle checkpoint 5.432E-9 1.734E-7 1.340E-6 6.937E-6 8 162
41 GO:0010948 negative regulation of cell cycle process 6.140E-9 1.912E-7 1.478E-6 7.841E-6 9 240
42 GO:0007050 cell cycle arrest 7.888E-9 2.358E-7 1.822E-6 1.007E-5 9 247
43 GO:1901988 negative regulation of cell cycle phase transition 7.938E-9 2.358E-7 1.822E-6 1.014E-5 8 170
44 GO:0072331 signal transduction by p53 class mediator 1.360E-8 3.948E-7 3.052E-6 1.737E-5 9 263
45 GO:0048146 positive regulation of fibroblast proliferation 1.443E-8 4.095E-7 3.165E-6 1.843E-5 6 67
46 GO:0045786 negative regulation of cell cycle 1.914E-8 5.314E-7 4.107E-6 2.444E-5 11 484
47 GO:1904031 positive regulation of cyclin-dependent protein kinase activity 3.471E-8 9.431E-7 7.290E-6 4.432E-5 5 38
48 GO:0097305 response to alcohol 3.645E-8 9.696E-7 7.495E-6 4.654E-5 10 398
49 GO:0045930 negative regulation of mitotic cell cycle 7.046E-8 1.836E-6 1.419E-5 8.998E-5 8 225
50 GO:0031100 animal organ regeneration 8.628E-8 2.204E-6 1.703E-5 1.102E-4 6 90
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 46 input genes in category / 104 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005664 nuclear origin of replication recognition complex 3.707E-9 1.927E-7 1.007E-6 3.855E-7 4 9
2 GO:0000808 origin recognition complex 3.707E-9 1.927E-7 1.007E-6 3.855E-7 4 9
3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex 1.255E-8 4.350E-7 2.274E-6 1.305E-6 5 32
4 GO:1902554 serine/threonine protein kinase complex 1.462E-6 3.097E-5 1.619E-4 1.521E-4 5 81
5 GO:0098687 chromosomal region 1.489E-6 3.097E-5 1.619E-4 1.549E-4 8 344
6 GO:0031461 cullin-RING ubiquitin ligase complex 1.809E-6 3.136E-5 1.639E-4 1.882E-4 6 154
7 GO:1902911 protein kinase complex 2.752E-6 4.088E-5 2.137E-4 2.862E-4 5 92
8 GO:0005819 spindle 8.378E-6 1.089E-4 5.692E-4 8.713E-4 7 308
9 GO:0000784 nuclear chromosome, telomeric region 1.671E-5 1.931E-4 1.009E-3 1.738E-3 5 133
10 GO:0000781 chromosome, telomeric region 4.312E-5 4.485E-4 2.344E-3 4.485E-3 5 162
11 GO:0000151 ubiquitin ligase complex 4.829E-5 4.565E-4 2.386E-3 5.022E-3 6 274
12 GO:0019005 SCF ubiquitin ligase complex 8.882E-5 7.698E-4 4.023E-3 9.237E-3 3 36
13 GO:0000776 kinetochore 2.254E-4 1.803E-3 9.423E-3 2.344E-2 4 124
14 GO:0061695 transferase complex, transferring phosphorus-containing groups 2.947E-4 2.189E-3 1.144E-2 3.065E-2 5 244
15 GO:0000775 chromosome, centromeric region 1.020E-3 7.069E-3 3.695E-2
1.060E-1
 4 185
16 GO:0005680 anaphase-promoting complex 1.276E-3 8.296E-3 4.336E-2
1.327E-1
 2 22
17 GO:0000777 condensed chromosome kinetochore 1.559E-3 9.536E-3 4.984E-2
1.621E-1
 3 95
18 GO:0000779 condensed chromosome, centromeric region 2.076E-3 1.199E-2
6.269E-2
2.159E-1
 3 105
19 GO:0031021 interphase microtubule organizing center 2.413E-3 1.321E-2
6.904E-2
2.510E-1
 1 1
20 GO:0000922 spindle pole 4.050E-3 2.089E-2
1.092E-1
4.212E-1
 3 133
21 GO:0000152 nuclear ubiquitin ligase complex 4.613E-3 2.089E-2
1.092E-1
4.798E-1
 2 42
22 GO:0070557 PCNA-p21 complex 4.821E-3 2.089E-2
1.092E-1
5.014E-1
 1 2
23 GO:0000939 condensed chromosome inner kinetochore 4.821E-3 2.089E-2
1.092E-1
5.014E-1
 1 2
24 GO:1990730 VCP-NSFL1C complex 4.821E-3 2.089E-2
1.092E-1
5.014E-1
 1 2
25 GO:0005876 spindle microtubule 9.227E-3 3.705E-2
1.936E-1
9.596E-1
 2 60
26 GO:0000942 condensed nuclear chromosome outer kinetochore 9.619E-3 3.705E-2
1.936E-1
1.000E0
 1 4
27 GO:0032777 Piccolo NuA4 histone acetyltransferase complex 9.619E-3 3.705E-2
1.936E-1
1.000E0
 1 4
28 GO:0072686 mitotic spindle 1.045E-2 3.880E-2
2.028E-1
1.000E0
 2 64
29 GO:0005667 transcription factor complex 1.178E-2 4.163E-2
2.176E-1
1.000E0
 4 368
30 GO:0032133 chromosome passenger complex 1.201E-2 4.163E-2
2.176E-1
1.000E0
 1 5
31 GO:0000793 condensed chromosome 1.378E-2 4.622E-2
2.416E-1
1.000E0
 3 208
32 GO:0001940 male pronucleus 1.439E-2 4.678E-2
2.445E-1
1.000E0
 1 6
Show 27 more annotations

4: Human Phenotype [Display Chart] 13 input genes in category / 1064 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011267 Microtia, third degree 1.143E-8 1.216E-5 9.177E-5 1.216E-5 4 11
2 HP:0009939 Mandibular aplasia 3.450E-8 1.224E-5 9.236E-5 3.671E-5 4 14
3 HP:0009892 Anotia 3.450E-8 1.224E-5 9.236E-5 3.671E-5 4 14
4 HP:0100783 Breast aplasia 6.254E-8 1.448E-5 1.093E-4 6.655E-5 4 16
5 HP:0000064 Hypoplastic labia minora 8.166E-8 1.448E-5 1.093E-4 8.689E-5 4 17
6 HP:0006660 Aplastic clavicle 8.166E-8 1.448E-5 1.093E-4 8.689E-5 4 17
7 HP:0006443 Patellar aplasia 1.655E-7 2.515E-5 1.898E-4 1.761E-4 4 20
8 HP:0012880 Abnormality of the labia minora 5.059E-7 6.729E-5 5.078E-4 5.383E-4 4 26
9 HP:0000059 Hypoplastic labia majora 6.908E-7 8.166E-5 6.164E-4 7.350E-4 4 28
10 HP:0003561 Birth length less than 3rd percentile 9.147E-7 9.733E-5 7.346E-4 9.733E-4 3 8
11 HP:0000060 Clitoral hypoplasia 1.370E-6 1.121E-4 8.463E-4 1.458E-3 4 33
12 HP:0006498 Aplasia/Hypoplasia of the patella 1.370E-6 1.121E-4 8.463E-4 1.458E-3 4 33
13 HP:0040255 Aplasia/Hypoplasia of the clitoris 1.370E-6 1.121E-4 8.463E-4 1.458E-3 4 33
14 HP:0012881 Abnormality of the labia majora 1.550E-6 1.178E-4 8.892E-4 1.649E-3 4 34
15 HP:0000898 Hypoplastic clavicles 1.963E-6 1.305E-4 9.852E-4 2.089E-3 4 36
16 HP:0000039 Epispadias 1.963E-6 1.305E-4 9.852E-4 2.089E-3 4 36
17 HP:0006710 Aplasia/Hypoplasia of the clavicles 2.452E-6 1.535E-4 1.158E-3 2.609E-3 4 38
18 HP:0000066 Labial hypoplasia 3.027E-6 1.789E-4 1.350E-3 3.221E-3 4 40
19 HP:0000327 Hypoplasia of the maxilla 8.057E-6 4.512E-4 3.405E-3 8.572E-3 5 113
20 HP:0012815 Hypoplastic female external genitalia 9.506E-6 5.057E-4 3.817E-3 1.011E-2 4 53
21 HP:0000413 Atresia of the external auditory canal 1.187E-5 6.013E-4 4.539E-3 1.263E-2 4 56
22 HP:0000176 Submucous cleft hard palate 1.566E-5 6.140E-4 4.634E-3 1.666E-2 4 60
23 HP:0040252 Abnormal size of the clitoris 1.566E-5 6.140E-4 4.634E-3 1.666E-2 4 60
24 HP:0410031 Submucous cleft of soft and hard palate 1.566E-5 6.140E-4 4.634E-3 1.666E-2 4 60
25 HP:0040253 Increased size of the clitoris 1.566E-5 6.140E-4 4.634E-3 1.666E-2 4 60
26 HP:0008665 Clitoral hypertrophy 1.566E-5 6.140E-4 4.634E-3 1.666E-2 4 60
27 HP:0010311 Aplasia/Hypoplasia of the breasts 1.673E-5 6.140E-4 4.634E-3 1.780E-2 4 61
28 HP:0410005 Cleft hard palate 1.673E-5 6.140E-4 4.634E-3 1.780E-2 4 61
29 HP:0000208 Submucous cleft lip/palate 1.673E-5 6.140E-4 4.634E-3 1.780E-2 4 61
30 HP:0000058 Abnormality of the labia 2.158E-5 7.652E-4 5.776E-3 2.296E-2 4 65
31 HP:0000189 Narrow palate 2.466E-5 8.026E-4 6.057E-3 2.624E-2 5 142
32 HP:0003042 Elbow dislocation 2.900E-5 8.026E-4 6.057E-3 3.085E-2 4 70
33 HP:0003045 Abnormality of the patella 3.068E-5 8.026E-4 6.057E-3 3.264E-2 4 71
34 HP:0030310 Upper extremity joint dislocation 3.068E-5 8.026E-4 6.057E-3 3.264E-2 4 71
35 HP:0100492 Joint contractures involving the joints of the feet 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
36 HP:0001220 Interphalangeal joint contracture of finger 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
37 HP:0005651 Flexion contracture of finger 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
38 HP:0012785 Flexion contracture of finger 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
39 HP:0100490 Camptodactyly of finger 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
40 HP:0001836 Camptodactyly of toe 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
41 HP:0010563 Camptodactyly (hands) 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
42 HP:0005830 Flexion contracture of toe 3.219E-5 8.026E-4 6.057E-3 3.425E-2 5 150
43 HP:0410004 Cleft secondary palate 3.243E-5 8.026E-4 6.057E-3 3.451E-2 4 72
44 HP:0001372 Joint contractures 3.657E-5 8.843E-4 6.674E-3 3.891E-2 5 154
45 HP:0000372 Abnormality of the auditory canal 4.020E-5 9.505E-4 7.174E-3 4.277E-2 4 76
46 HP:0006261 Abnormal phalangeal joint morphology of the hand 4.140E-5 9.576E-4 7.228E-3 4.405E-2 5 158
47 HP:0003061 Gracile long bones 4.456E-5 9.876E-4 7.454E-3 4.741E-2 4 78
48 HP:0003100 Slender long bone 4.456E-5 9.876E-4 7.454E-3 4.741E-2 4 78
49 HP:0012471 Thick vermilion border 5.104E-5 1.108E-3 8.365E-3
5.431E-2
 5 165
50 HP:0005692 Joint hyperflexibility 6.591E-5 1.375E-3 1.038E-2
7.013E-2
 5 174
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 39 input genes in category / 1340 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0003077 abnormal cell cycle 2.341E-8 3.137E-5 2.440E-4 3.137E-5 11 332
2 MP:0004046 abnormal mitosis 9.644E-8 6.462E-5 5.026E-4 1.292E-4 8 157
3 MP:0002052 decreased tumor incidence 1.110E-6 4.960E-4 3.858E-3 1.488E-3 8 216
4 MP:0000490 abnormal crypts of Lieberkuhn morphology 2.492E-6 8.349E-4 6.494E-3 3.340E-3 7 167
5 MP:0000488 abnormal intestinal epithelium morphology 3.630E-6 9.728E-4 7.566E-3 4.864E-3 8 253
6 MP:0008108 abnormal small intestinal villus morphology 1.137E-5 2.539E-3 1.975E-2 1.523E-2 5 80
7 MP:0000511 abnormal intestinal mucosa morphology 1.443E-5 2.763E-3 2.149E-2 1.934E-2 7 218
8 MP:0002145 abnormal T cell differentiation 2.187E-5 3.664E-3 2.850E-2 2.931E-2 9 426
9 MP:0005094 abnormal T cell proliferation 3.075E-5 4.578E-3 3.561E-2 4.121E-2 8 339
10 MP:0004808 abnormal hematopoietic stem cell morphology 3.491E-5 4.678E-3 3.639E-2 4.678E-2 6 168
11 MP:0010268 decreased lymphoma incidence 3.876E-5 4.722E-3 3.673E-2
5.194E-2
 3 18
12 MP:0006204 embryonic lethality before implantation 5.142E-5 5.270E-3 4.099E-2
6.890E-2
 6 180
13 MP:0002407 abnormal double-negative T cell morphology 5.303E-5 5.270E-3 4.099E-2
7.106E-2
 6 181
14 MP:0008142 decreased small intestinal villus size 6.269E-5 5.270E-3 4.099E-2
8.400E-2
 3 21
15 MP:0001828 abnormal T cell activation 6.793E-5 5.270E-3 4.099E-2
9.103E-2
 8 379
16 MP:0003111 abnormal cell nucleus morphology 7.582E-5 5.270E-3 4.099E-2
1.016E-1
 6 193
17 MP:0020459 abnormal gum morphology 8.254E-5 5.270E-3 4.099E-2
1.106E-1
 2 4
18 MP:0010159 abnormal enterocyte differentiation 8.254E-5 5.270E-3 4.099E-2
1.106E-1
 2 4
19 MP:0030516 abnormal junctional epithelium morphology 8.254E-5 5.270E-3 4.099E-2
1.106E-1
 2 4
20 MP:0020460 abnormal gum epithelium morphology 8.254E-5 5.270E-3 4.099E-2
1.106E-1
 2 4
21 MP:0005092 decreased double-positive T cell number 8.259E-5 5.270E-3 4.099E-2
1.107E-1
 6 196
22 MP:0010763 abnormal hematopoietic stem cell physiology 9.279E-5 5.652E-3 4.396E-2
1.243E-1
 4 64
23 MP:0005095 decreased T cell proliferation 1.087E-4 6.334E-3 4.926E-2
1.457E-1
 6 206
24 MP:0009300 increased parametrial fat pad weight 1.372E-4 7.560E-3
5.880E-2
1.839E-1
 2 5
25 MP:0001823 thymus hypoplasia 1.410E-4 7.560E-3
5.880E-2
1.890E-1
 6 216
26 MP:0010283 decreased classified tumor incidence 1.516E-4 7.814E-3
6.078E-2
2.032E-1
 3 28
27 MP:0006410 abnormal common myeloid progenitor cell morphology 1.673E-4 8.246E-3
6.414E-2
2.242E-1
 5 140
28 MP:0008008 early cellular replicative senescence 1.723E-4 8.246E-3
6.414E-2
2.309E-1
 4 75
29 MP:0001586 abnormal erythrocyte cell number 1.855E-4 8.382E-3
6.519E-2
2.486E-1
 7 326
30 MP:0008882 abnormal enterocyte physiology 1.908E-4 8.382E-3
6.519E-2
2.557E-1
 4 77
31 MP:0009781 abnormal preimplantation embryo development 2.006E-4 8.382E-3
6.519E-2
2.688E-1
 4 78
32 MP:0013958 decreased small intestine length 2.054E-4 8.382E-3
6.519E-2
2.752E-1
 2 6
33 MP:0004025 polyploidy 2.064E-4 8.382E-3
6.519E-2
2.766E-1
 3 31
34 MP:0000245 abnormal erythropoiesis 2.169E-4 8.549E-3
6.650E-2
2.907E-1
 5 148
35 MP:0002408 abnormal double-positive T cell morphology 2.285E-4 8.747E-3
6.803E-2
3.061E-1
 6 236
36 MP:0011094 embryonic lethality before implantation, complete penetrance 2.456E-4 9.142E-3
7.111E-2
3.291E-1
 5 152
37 MP:0002875 decreased erythrocyte cell number 2.617E-4 9.477E-3
7.371E-2
3.506E-1
 6 242
38 MP:0008007 abnormal cellular replicative senescence 3.192E-4 1.097E-2
8.530E-2
4.277E-1
 4 88
39 MP:0004023 abnormal chromosome number 3.192E-4 1.097E-2
8.530E-2
4.277E-1
 4 88
40 MP:0012431 increased lymphoma incidence 3.467E-4 1.148E-2
8.930E-2
4.646E-1
 6 255
41 MP:0010320 increased pituitary gland tumor incidence 3.513E-4 1.148E-2
8.930E-2
4.707E-1
 3 37
42 MP:0009381 abnormal prostate gland dorsolateral lobe morphology 3.815E-4 1.189E-2
9.248E-2
5.113E-1
 2 8
43 MP:0030179 abnormal oral epithelium morphology 3.815E-4 1.189E-2
9.248E-2
5.113E-1
 2 8
44 MP:0004810 decreased hematopoietic stem cell number 4.276E-4 1.302E-2
1.013E-1
5.730E-1
 4 95
45 MP:0008906 abnormal parametrial fat pad morphology 4.894E-4 1.457E-2
1.133E-1
6.558E-1
 2 9
46 MP:0003667 increased hemangiosarcoma incidence 5.879E-4 1.619E-2
1.259E-1
7.878E-1
 3 44
47 MP:0002024 increased T cell derived lymphoma incidence 6.028E-4 1.619E-2
1.259E-1
8.077E-1
 4 104
48 MP:0009130 increased white fat cell number 6.103E-4 1.619E-2
1.259E-1
8.178E-1
 2 10
49 MP:0000715 decreased thymocyte number 6.215E-4 1.619E-2
1.259E-1
8.328E-1
 5 186
50 MP:0010365 increased thymus tumor incidence 6.250E-4 1.619E-2
1.259E-1
8.374E-1
 4 105
Show 45 more annotations

6: Domain [Display Chart] 46 input genes in category / 257 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR004367 Cyclin C-dom InterPro 7.394E-8 6.334E-6 3.882E-5 1.900E-5 4 17
2 SM01332 Cyclin C SMART 7.394E-8 6.334E-6 3.882E-5 1.900E-5 4 17
3 PF02984 Cyclin C Pfam 7.394E-8 6.334E-6 3.882E-5 1.900E-5 4 17
4 IPR016239 Ribosomal S6 kinase II InterPro 2.756E-7 1.771E-5 1.085E-4 7.084E-5 3 6
5 PS00292 CYCLINS PROSITE 6.236E-7 3.205E-5 1.964E-4 1.603E-4 4 28
6 PF00134 Cyclin N Pfam 1.235E-6 4.535E-5 2.779E-4 3.175E-4 4 33
7 IPR006671 Cyclin N InterPro 1.235E-6 4.535E-5 2.779E-4 3.175E-4 4 33
8 SM00385 CYCLIN SMART 2.208E-6 5.775E-5 3.539E-4 5.675E-4 4 38
9 IPR008271 Ser/Thr kinase AS InterPro 2.229E-6 5.775E-5 3.539E-4 5.730E-4 8 357
10 SM00220 S TKc SMART 2.324E-6 5.775E-5 3.539E-4 5.972E-4 8 359
11 PS00108 PROTEIN KINASE ST PROSITE 2.472E-6 5.775E-5 3.539E-4 6.353E-4 8 362
12 1.10.472.10 - Gene3D 2.724E-6 5.835E-5 3.576E-4 7.002E-4 4 40
13 PF00069 Pkinase Pfam 3.609E-6 6.717E-5 4.116E-4 9.276E-4 8 381
14 IPR013763 Cyclin-like InterPro 3.659E-6 6.717E-5 4.116E-4 9.404E-4 4 43
15 IPR021977 Beta-TrCP D InterPro 5.898E-6 8.916E-5 5.464E-4 1.516E-3 2 2
16 SM01028 Beta-TrCP D SMART 5.898E-6 8.916E-5 5.464E-4 1.516E-3 2 2
17 PF12125 Beta-TrCP D Pfam 5.898E-6 8.916E-5 5.464E-4 1.516E-3 2 2
18 PS00107 PROTEIN KINASE ATP PROSITE 1.407E-5 2.009E-4 1.231E-3 3.616E-3 8 459
19 PF02234 CDI Pfam 1.767E-5 2.064E-4 1.265E-3 4.540E-3 2 3
20 IPR003175 CDI InterPro 1.767E-5 2.064E-4 1.265E-3 4.540E-3 2 3
21 PF06617 M-inducer phosp Pfam 1.767E-5 2.064E-4 1.265E-3 4.540E-3 2 3
22 IPR000751 MPI Phosphatase InterPro 1.767E-5 2.064E-4 1.265E-3 4.540E-3 2 3
23 IPR000719 Prot kinase dom InterPro 2.219E-5 2.479E-4 1.519E-3 5.702E-3 8 489
24 PS50011 PROTEIN KINASE DOM PROSITE 2.352E-5 2.519E-4 1.544E-3 6.045E-3 8 493
25 IPR017441 Protein kinase ATP BS InterPro 3.558E-5 3.657E-4 2.241E-3 9.143E-3 7 379
26 IPR032198 E2F CC-MB InterPro 8.791E-5 8.368E-4 5.128E-3 2.259E-2 2 6
27 PF16421 E2F CC-MB Pfam 8.791E-5 8.368E-4 5.128E-3 2.259E-2 2 6
28 IPR017892 Pkinase C InterPro 1.015E-4 9.318E-4 5.710E-3 2.609E-2 3 37
29 PF00433 Pkinase C Pfam 1.487E-4 1.318E-3 8.076E-3 3.822E-2 3 42
30 IPR015633 E2F InterPro 1.636E-4 1.401E-3 8.588E-3 4.204E-2 2 8
31 PF12937 F-box-like Pfam 1.710E-4 1.417E-3 8.686E-3 4.394E-2 3 44
32 SM00256 FBOX SMART 2.814E-4 2.163E-3 1.326E-2
7.232E-2
 3 52
33 PF00004 AAA Pfam 2.814E-4 2.163E-3 1.326E-2
7.232E-2
 3 52
34 IPR011991 WHTH DNA-bd dom InterPro 3.129E-4 2.163E-3 1.326E-2
8.042E-2
 5 243
35 IPR003959 ATPase AAA core InterPro 3.147E-4 2.163E-3 1.326E-2
8.089E-2
 3 54
36 SM01372 E2F TDP SMART 3.198E-4 2.163E-3 1.326E-2
8.220E-2
 2 11
37 PF02319 E2F TDP Pfam 3.198E-4 2.163E-3 1.326E-2
8.220E-2
 2 11
38 IPR003316 E2F WHTH DNA-bd dom InterPro 3.198E-4 2.163E-3 1.326E-2
8.220E-2
 2 11
39 PS51285 AGC KINASE CTER PROSITE 3.505E-4 2.197E-3 1.347E-2
9.009E-2
 3 56
40 IPR000961 AGC-kinase C InterPro 3.505E-4 2.197E-3 1.347E-2
9.009E-2
 3 56
41 SM00133 S TK X SMART 3.505E-4 2.197E-3 1.347E-2
9.009E-2
 3 56
42 PF00646 F-box Pfam 5.945E-4 3.638E-3 2.229E-2
1.528E-1
 3 67
43 PS50181 FBOX PROSITE 7.338E-4 4.386E-3 2.688E-2
1.886E-1
 3 72
44 IPR001810 F-box dom InterPro 8.265E-4 4.828E-3 2.959E-2
2.124E-1
 3 75
45 SM00450 RHOD SMART 1.320E-3 7.090E-3 4.345E-2
3.393E-1
 2 22
46 PS50206 RHODANESE 3 PROSITE 1.444E-3 7.090E-3 4.345E-2
3.711E-1
 2 23
47 IPR001763 Rhodanese-like dom InterPro 1.573E-3 7.090E-3 4.345E-2
4.042E-1
 2 24
48 PF00581 Rhodanese Pfam 1.573E-3 7.090E-3 4.345E-2
4.042E-1
 2 24
49 3.40.250.10 - Gene3D 1.573E-3 7.090E-3 4.345E-2
4.042E-1
 2 24
50 PS00091 THYMIDYLATE SYNTHASE PROSITE 2.455E-3 7.090E-3 4.345E-2
6.310E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 45 input genes in category / 530 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83054 Cell cycle BioSystems: KEGG 4.840E-31 2.565E-28 1.757E-27 2.565E-28 21 124
2 1269764 Mitotic G1-G1/S phases BioSystems: REACTOME 1.635E-29 4.333E-27 2.969E-26 8.666E-27 21 145
3 1269768 G1/S Transition BioSystems: REACTOME 1.692E-23 2.989E-21 2.048E-20 8.966E-21 17 121
4 1269774 E2F mediated regulation of DNA replication BioSystems: REACTOME 9.866E-20 1.307E-17 8.956E-17 5.229E-17 11 34
5 1269742 Cell Cycle Checkpoints BioSystems: REACTOME 6.360E-18 6.741E-16 4.619E-15 3.371E-15 16 204
6 1269777 S Phase BioSystems: REACTOME 1.417E-17 1.197E-15 8.198E-15 7.508E-15 14 132
7 137934 E2F transcription factor network BioSystems: Pathway Interaction Database 1.581E-17 1.197E-15 8.198E-15 8.377E-15 12 73
8 M17770 Cyclins and Cell Cycle Regulation MSigDB C2 BIOCARTA (v6.0) 3.536E-17 2.342E-15 1.605E-14 1.874E-14 9 23
9 1269795 Association of licensing factors with the pre-replicative complex BioSystems: REACTOME 9.532E-17 5.613E-15 3.846E-14 5.052E-14 8 15
10 1269776 E2F-enabled inhibition of pre-replication complex formation BioSystems: REACTOME 5.882E-16 3.098E-14 2.123E-13 3.118E-13 7 10
11 M6682 CDK Regulation of DNA Replication MSigDB C2 BIOCARTA (v6.0) 6.431E-16 3.098E-14 2.123E-13 3.408E-13 8 18
12 1269794 Regulation of DNA replication BioSystems: REACTOME 2.783E-15 1.229E-13 8.421E-13 1.475E-12 11 79
13 1269767 Cyclin D associated events in G1 BioSystems: REACTOME 8.794E-15 3.329E-13 2.281E-12 4.661E-12 9 39
14 1269766 G1 Phase BioSystems: REACTOME 8.794E-15 3.329E-13 2.281E-12 4.661E-12 9 39
15 M648 Cell Cycle: G1/S Check Point MSigDB C2 BIOCARTA (v6.0) 4.448E-14 1.572E-12 1.077E-11 2.358E-11 8 28
16 1383071 TP53 Regulates Transcription of Cell Cycle Genes BioSystems: REACTOME 8.305E-14 2.751E-12 1.885E-11 4.402E-11 9 49
17 1269796 Removal of licensing factors from origins BioSystems: REACTOME 1.046E-13 3.262E-12 2.235E-11 5.546E-11 10 76
18 1269875 DNA Replication BioSystems: REACTOME 1.344E-13 3.959E-12 2.712E-11 7.125E-11 11 111
19 1269835 CDC6 association with the ORC:origin complex BioSystems: REACTOME 7.187E-13 2.005E-11 1.373E-10 3.809E-10 6 11
20 M3686 Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. MSigDB C2 BIOCARTA (v6.0) 2.655E-12 7.036E-11 4.820E-10 1.407E-9 6 13
21 1270426 Cellular Senescence BioSystems: REACTOME 3.207E-12 8.095E-11 5.546E-10 1.700E-9 12 197
22 1269782 Orc1 removal from chromatin BioSystems: REACTOME 4.185E-12 9.645E-11 6.608E-10 2.218E-9 9 74
23 1269781 Switching of origins to a post-replicative state BioSystems: REACTOME 4.185E-12 9.645E-11 6.608E-10 2.218E-9 9 74
24 126909 Oocyte meiosis BioSystems: KEGG 1.581E-11 3.492E-10 2.392E-9 8.380E-9 10 124
25 1269772 G1/S-Specific Transcription BioSystems: REACTOME 2.834E-11 6.008E-10 4.116E-9 1.502E-8 6 18
26 119304 Progesterone-mediated oocyte maturation BioSystems: KEGG 4.635E-11 9.216E-10 6.314E-9 2.457E-8 9 96
27 1269757 Activation of ATR in response to replication stress BioSystems: REACTOME 4.695E-11 9.216E-10 6.314E-9 2.488E-8 7 37
28 1269779 Synthesis of DNA BioSystems: REACTOME 8.809E-11 1.667E-9 1.142E-8 4.669E-8 9 103
29 1269833 Assembly of the pre-replicative complex BioSystems: REACTOME 1.359E-10 2.483E-9 1.701E-8 7.201E-8 8 71
30 1269778 Cyclin A:Cdk2-associated events at S phase entry BioSystems: REACTOME 1.707E-10 2.970E-9 2.034E-8 9.050E-8 8 73
31 1270431 Senescence-Associated Secretory Phenotype (SASP) BioSystems: REACTOME 1.737E-10 2.970E-9 2.034E-8 9.206E-8 9 111
32 1269769 Cyclin E associated events during G1/S transition BioSystems: REACTOME 1.909E-10 3.162E-9 2.167E-8 1.012E-7 8 74
33 M8560 Cell Cycle: G2/M Checkpoint MSigDB C2 BIOCARTA (v6.0) 2.022E-10 3.247E-9 2.225E-8 1.072E-7 6 24
34 1269765 G0 and Early G1 BioSystems: REACTOME 2.653E-10 4.136E-9 2.833E-8 1.406E-7 6 25
35 1270414 Cellular responses to stress BioSystems: REACTOME 3.569E-10 5.404E-9 3.702E-8 1.891E-7 14 454
36 1269753 G2/M Checkpoints BioSystems: REACTOME 4.095E-10 6.029E-9 4.130E-8 2.170E-7 10 172
37 1269831 M/G1 Transition BioSystems: REACTOME 7.846E-10 1.078E-8 7.385E-8 4.158E-7 8 88
38 1269832 DNA Replication Pre-Initiation BioSystems: REACTOME 7.846E-10 1.078E-8 7.385E-8 4.158E-7 8 88
39 1269799 G2/M Transition BioSystems: REACTOME 7.932E-10 1.078E-8 7.385E-8 4.204E-7 10 184
40 1269797 Mitotic G2-G2/M phases BioSystems: REACTOME 8.816E-10 1.168E-8 8.003E-8 4.672E-7 10 186
41 1269773 Activation of the pre-replicative complex BioSystems: REACTOME 1.332E-9 1.722E-8 1.180E-7 7.061E-7 6 32
42 1269836 CDT1 association with the CDC6:ORC:origin complex BioSystems: REACTOME 2.097E-9 2.647E-8 1.813E-7 1.112E-6 7 62
43 1269834 Assembly of the ORC complex at the origin of replication BioSystems: REACTOME 2.222E-9 2.739E-8 1.876E-7 1.178E-6 4 6
44 1269770 SCF(Skp2)-mediated degradation of p27/p21 BioSystems: REACTOME 2.353E-9 2.834E-8 1.942E-7 1.247E-6 7 63
45 137935 FOXM1 transcription factor network BioSystems: Pathway Interaction Database 3.372E-9 3.972E-8 2.721E-7 1.787E-6 6 37
46 83055 p53 signaling pathway BioSystems: KEGG 4.516E-9 5.203E-8 3.564E-7 2.393E-6 7 69
47 1269800 Cyclin A/B1 associated events during G2/M transition BioSystems: REACTOME 1.234E-8 1.392E-7 9.535E-7 6.541E-6 5 22
48 169351 Validated targets of C-MYC transcriptional activation BioSystems: Pathway Interaction Database 1.409E-8 1.556E-7 1.066E-6 7.469E-6 7 81
49 83118 Small cell lung cancer BioSystems: KEGG 1.821E-8 1.970E-7 1.349E-6 9.651E-6 7 84
50 1269837 Regulation of mitotic cell cycle BioSystems: REACTOME 2.733E-8 2.840E-7 1.946E-6 1.449E-5 7 89
Show 45 more annotations

8: Pubmed [Display Chart] 46 input genes in category / 13174 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19738611 Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis. Pubmed 7.413E-27 9.765E-23 9.827E-22 9.765E-23 12 39
2 15232106 Self-assembling protein microarrays. Pubmed 1.137E-25 7.487E-22 7.534E-21 1.497E-21 11 30
3 11931757 Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication. Pubmed 1.175E-23 5.159E-20 5.192E-19 1.548E-19 10 26
4 23455922 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Pubmed 1.321E-21 4.352E-18 4.379E-17 1.741E-17 17 446
5 15730892 Expression of cell cycle-related proteins in developing and adult mouse hippocampus. Pubmed 1.487E-20 3.425E-17 3.447E-16 1.959E-16 8 15
6 16007079 Cdc2-cyclin E complexes regulate the G1/S phase transition. Pubmed 1.820E-20 3.425E-17 3.447E-16 2.397E-16 7 8
7 9716181 Differential modulation of G1-S-phase cyclin-dependent kinase 2/cyclin complexes occurs during the acquisition of a polyploid DNA content. Pubmed 1.820E-20 3.425E-17 3.447E-16 2.397E-16 7 8
8 15315760 Mouse development and cell proliferation in the absence of D-cyclins. Pubmed 2.972E-20 4.894E-17 4.925E-16 3.915E-16 8 16
9 11125146 Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. Pubmed 2.725E-19 3.989E-16 4.014E-15 3.590E-15 7 10
10 11095619 Induction of cell cycle entry and cell death in postmitotic lens fiber cells by overexpression of E2F1 or E2F2. Pubmed 1.795E-18 2.365E-15 2.380E-14 2.365E-14 7 12
11 8756624 Cyclin-binding motifs are essential for the function of p21CIP1. Pubmed 3.886E-18 4.654E-15 4.684E-14 5.120E-14 7 13
12 9190208 Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Pubmed 7.765E-18 8.525E-15 8.579E-14 1.023E-13 7 14
13 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 9.437E-18 9.564E-15 9.624E-14 1.243E-13 14 371
14 14993212 Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. Pubmed 1.520E-17 1.431E-14 1.440E-13 2.003E-13 6 7
15 10339564 Multistep regulation of DNA replication by Cdk phosphorylation of HsCdc6. Pubmed 6.075E-17 5.002E-14 5.034E-13 8.004E-13 6 8
16 20932478 A WD-repeat protein stabilizes ORC binding to chromatin. Pubmed 6.075E-17 5.002E-14 5.034E-13 8.004E-13 6 8
17 27141870 Expression of histone deacetylase 3 instructs alveolar type I cell differentiation by regulating a Wnt signaling niche in the lung. Pubmed 6.864E-17 5.320E-14 5.353E-13 9.043E-13 8 36
18 22560297 Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Pubmed 9.348E-17 6.842E-14 6.885E-13 1.231E-12 11 167
19 12852854 jumonji downregulates cardiac cell proliferation by repressing cyclin D1 expression. Pubmed 1.821E-16 1.263E-13 1.271E-12 2.399E-12 6 9
20 19265663 Stage-specific control of neural crest stem cell proliferation by the small rho GTPases Cdc42 and Rac1. Pubmed 2.615E-16 1.722E-13 1.733E-12 3.444E-12 7 21
21 24886500 G1 checkpoint establishment in vivo during embryonic liver development. Pubmed 4.548E-16 2.497E-13 2.512E-12 5.992E-12 6 10
22 24358021 Polycomb protein SCML2 regulates the cell cycle by binding and modulating CDK/CYCLIN/p21 complexes. Pubmed 4.548E-16 2.497E-13 2.512E-12 5.992E-12 6 10
23 15159393 Cyclin A2 mediates cardiomyocyte mitosis in the postmitotic myocardium. Pubmed 4.548E-16 2.497E-13 2.512E-12 5.992E-12 6 10
24 9856457 Growth arrest failure, G1 restriction point override, and S phase death of sensory precursor cells in the absence of neurotrophin-3. Pubmed 4.548E-16 2.497E-13 2.512E-12 5.992E-12 6 10
25 28923932 Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Pubmed 5.503E-16 2.900E-13 2.918E-12 7.249E-12 7 23
26 15707957 Functional interaction of Puralpha with the Cdk2 moiety of cyclin A/Cdk2. Pubmed 9.997E-16 4.390E-13 4.418E-12 1.317E-11 6 11
27 22158041 A p27Kip1 mutant that does not inhibit CDK activity promotes centrosome amplification and micronucleation. Pubmed 9.997E-16 4.390E-13 4.418E-12 1.317E-11 6 11
28 8662825 Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. Pubmed 9.997E-16 4.390E-13 4.418E-12 1.317E-11 6 11
29 10766737 Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression. Pubmed 9.997E-16 4.390E-13 4.418E-12 1.317E-11 6 11
30 15050687 Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein. Pubmed 9.997E-16 4.390E-13 4.418E-12 1.317E-11 6 11
31 25784544 Legacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function. Pubmed 1.472E-15 6.258E-13 6.297E-12 1.940E-11 7 26
32 18507837 Effects of common germline genetic variation in cell cycle control genes on breast cancer survival: results from a population-based cohort. Pubmed 3.707E-15 1.436E-12 1.445E-11 4.883E-11 6 13
33 18174243 Association of single-nucleotide polymorphisms in the cell cycle genes with breast cancer in the British population. Pubmed 3.707E-15 1.436E-12 1.445E-11 4.883E-11 6 13
34 17409409 Tagging single nucleotide polymorphisms in cell cycle control genes and susceptibility to invasive epithelial ovarian cancer. Pubmed 3.707E-15 1.436E-12 1.445E-11 4.883E-11 6 13
35 23342106 Mechanistic target of rapamycin (Mtor) is essential for murine embryonic heart development and growth. Pubmed 5.860E-15 2.206E-12 2.220E-11 7.720E-11 7 31
36 18281541 Effects of common germ-line genetic variation in cell cycle genes on ovarian cancer survival. Pubmed 6.481E-15 2.372E-12 2.387E-11 8.538E-11 6 14
37 20453000 A Large-scale genetic association study of esophageal adenocarcinoma risk. Pubmed 8.844E-15 3.149E-12 3.169E-11 1.165E-10 12 351
38 10436018 The Cdc6 nucleotide-binding site regulates its activity in DNA replication in human cells. Pubmed 1.079E-14 3.554E-12 3.577E-11 1.422E-10 6 15
39 25196150 FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Pubmed 1.079E-14 3.554E-12 3.577E-11 1.422E-10 6 15
40 9891079 Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. Pubmed 1.079E-14 3.554E-12 3.577E-11 1.422E-10 6 15
41 8822197 Formation of p27-CDK complexes during the human mitotic cell cycle. Pubmed 1.214E-14 3.900E-12 3.924E-11 1.599E-10 5 6
42 21690373 Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Pubmed 1.725E-14 5.285E-12 5.319E-11 2.273E-10 6 16
43 11095689 The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase. Pubmed 1.725E-14 5.285E-12 5.319E-11 2.273E-10 6 16
44 17000767 Ribosomal protein S6 gene haploinsufficiency is associated with activation of a p53-dependent checkpoint during gastrulation. Pubmed 2.664E-14 7.975E-12 8.026E-11 3.509E-10 6 17
45 12045100 DNA replication in eukaryotic cells. Pubmed 3.992E-14 1.169E-11 1.176E-10 5.259E-10 6 18
46 17679094 APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase. Pubmed 4.244E-14 1.204E-11 1.212E-10 5.591E-10 5 7
47 25852190 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Pubmed 4.297E-14 1.204E-11 1.212E-10 5.660E-10 12 401
48 29997244 LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells. Pubmed 8.465E-14 2.323E-11 2.338E-10 1.115E-9 9 139
49 15980415 Ubiquitination of p27Kip1 requires physical interaction with cyclin E and probable phosphate recognition by SKP2. Pubmed 1.131E-13 2.921E-11 2.939E-10 1.490E-9 5 8
50 15684404 Involvement of human MCM8 in prereplication complex assembly by recruiting hcdc6 to chromatin. Pubmed 1.131E-13 2.921E-11 2.939E-10 1.490E-9 5 8
Show 45 more annotations

9: Interaction [Display Chart] 46 input genes in category / 3451 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CDK1 CDK1 interactions 2.779E-24 9.591E-21 8.367E-20 9.591E-21 21 344
2 int:FZR1 FZR1 interactions 5.613E-23 9.685E-20 8.449E-19 1.937E-19 17 176
3 int:CDC6 CDC6 interactions 1.152E-22 1.326E-19 1.156E-18 3.977E-19 14 81
4 int:CCNA2 CCNA2 interactions 1.097E-21 9.468E-19 8.259E-18 3.787E-18 15 126
5 int:CCNE1 CCNE1 interactions 4.190E-21 2.892E-18 2.523E-17 1.446E-17 14 103
6 int:CDK3 CDK3 interactions 1.020E-20 5.864E-18 5.116E-17 3.519E-17 12 56
7 int:CDT1 CDT1 interactions 8.831E-20 4.354E-17 3.798E-16 3.047E-16 12 66
8 int:CDC20 CDC20 interactions 1.643E-19 7.085E-17 6.181E-16 5.668E-16 15 174
9 int:SKP2 SKP2 interactions 2.536E-19 9.173E-17 8.002E-16 8.753E-16 15 179
10 int:CDKN1B CDKN1B interactions 2.658E-19 9.173E-17 8.002E-16 9.173E-16 13 101
11 int:E2F1 E2F1 interactions 2.544E-18 7.981E-16 6.962E-15 8.779E-15 14 160
12 int:E2F4 E2F4 interactions 3.087E-18 8.877E-16 7.744E-15 1.065E-14 13 121
13 int:CDK4 CDK4 interactions 5.473E-18 1.453E-15 1.267E-14 1.889E-14 15 219
14 int:CDKN1A CDKN1A interactions 2.281E-17 5.622E-15 4.904E-14 7.870E-14 16 303
15 int:CCNB1 CCNB1 interactions 7.120E-17 1.638E-14 1.429E-13 2.457E-13 13 153
16 int:RBL2 RBL2 interactions 9.225E-17 1.990E-14 1.736E-13 3.184E-13 11 80
17 int:CKS1B CKS1B interactions 1.082E-16 2.196E-14 1.916E-13 3.734E-13 10 54
18 int:CKS2 CKS2 interactions 2.099E-16 4.024E-14 3.510E-13 7.243E-13 9 36
19 int:CDC25A CDC25A interactions 4.084E-16 7.418E-14 6.471E-13 1.409E-12 11 91
20 int:SKP1 SKP1 interactions 9.715E-14 1.675E-11 1.461E-10 3.353E-10 13 266
21 int:RB1 RB1 interactions 1.019E-13 1.675E-11 1.461E-10 3.518E-10 13 267
22 int:CCNA1 CCNA1 interactions 7.557E-13 1.185E-10 1.034E-9 2.608E-9 8 52
23 int:ORC1 ORC1 interactions 1.041E-12 1.562E-10 1.362E-9 3.592E-9 8 54
24 int:E2F3 E2F3 interactions 1.416E-12 2.036E-10 1.776E-9 4.885E-9 8 56
25 int:CDK5 CDK5 interactions 2.550E-12 3.520E-10 3.071E-9 8.801E-9 10 142
26 int:PCNA PCNA interactions 2.224E-11 2.952E-9 2.576E-8 7.676E-8 12 320
27 int:GMNN GMNN interactions 4.118E-11 5.263E-9 4.592E-8 1.421E-7 8 84
28 int:CDKN1C CDKN1C interactions 6.232E-11 7.681E-9 6.701E-8 2.151E-7 6 27
29 int:MCM10 MCM10 interactions 2.461E-10 2.929E-8 2.555E-7 8.493E-7 7 63
30 int:CDK6 CDK6 interactions 3.135E-10 3.607E-8 3.146E-7 1.082E-6 9 163
31 int:FBXO5 FBXO5 interactions 3.365E-10 3.746E-8 3.268E-7 1.161E-6 6 35
32 int:ORC2 ORC2 interactions 4.271E-10 4.606E-8 4.018E-7 1.474E-6 7 68
33 int:SP1 SP1 interactions 1.084E-9 1.133E-7 9.886E-7 3.739E-6 10 262
34 int:E2F2 E2F2 interactions 1.438E-9 1.460E-7 1.273E-6 4.962E-6 6 44
35 int:MAPK14 MAPK14 interactions 1.557E-9 1.535E-7 1.339E-6 5.373E-6 10 272
36 int:ORC3 ORC3 interactions 1.901E-9 1.822E-7 1.589E-6 6.559E-6 6 46
37 int:TP73 TP73 interactions 2.533E-9 2.363E-7 2.061E-6 8.742E-6 8 140
38 int:BTRC BTRC interactions 4.844E-9 4.399E-7 3.838E-6 1.672E-5 11 403
39 int:USP37 USP37 interactions 5.752E-9 5.089E-7 4.440E-6 1.985E-5 7 98
40 int:CHEK1 CHEK1 interactions 6.594E-9 5.689E-7 4.963E-6 2.276E-5 8 158
41 int:UHRF2 UHRF2 interactions 9.335E-9 7.858E-7 6.855E-6 3.222E-5 7 105
42 int:NFKBIA NFKBIA interactions 1.069E-8 8.780E-7 7.659E-6 3.687E-5 8 168
43 int:HIST3H3 HIST3H3 interactions 1.775E-8 1.419E-6 1.238E-5 6.127E-5 9 258
44 int:ARID4A ARID4A interactions 1.809E-8 1.419E-6 1.238E-5 6.244E-5 5 32
45 int:CDC37 CDC37 interactions 2.028E-8 1.555E-6 1.357E-5 6.999E-5 9 262
46 int:CCND3 CCND3 interactions 2.128E-8 1.563E-6 1.363E-5 7.344E-5 6 68
47 int:ORC6 ORC6 interactions 2.128E-8 1.563E-6 1.363E-5 7.345E-5 5 33
48 int:HIST1H1B HIST1H1B interactions 2.326E-8 1.673E-6 1.459E-5 8.028E-5 6 69
49 int:CCND1 CCND1 interactions 2.813E-8 1.981E-6 1.729E-5 9.709E-5 7 123
50 int:CCNB2 CCNB2 interactions 3.361E-8 2.320E-6 2.024E-5 1.160E-4 5 36
Show 45 more annotations

10: Cytoband [Display Chart] 45 input genes in category / 42 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q33 2q33 6.544E-4 7.790E-3 3.370E-2 2.748E-2 2 29
2 6p21.2 6p21.2 1.185E-3 7.790E-3 3.370E-2 4.975E-2 2 39
3 16q21-q22 16q21-q22 1.298E-3 7.790E-3 3.370E-2
5.453E-2
 1 1
4 6q14.3-q16.1 6q14.3-q16.1 1.298E-3 7.790E-3 3.370E-2
5.453E-2
 1 1
5 17q23.2-q25.3 17q23.2-q25.3 1.298E-3 7.790E-3 3.370E-2
5.453E-2
 1 1
6 12p13.1-p12 12p13.1-p12 1.298E-3 7.790E-3 3.370E-2
5.453E-2
 1 1
7 11q11-q13 11q11-q13 1.298E-3 7.790E-3 3.370E-2
5.453E-2
 1 1
8 2q22-q23 2q22-q23 3.890E-3 2.042E-2
8.836E-2
1.634E-1
 1 3
9 Xp22.2-p22.1 Xp22.2-p22.1 6.475E-3 2.965E-2
1.283E-1
2.719E-1
 1 5
10 17q22-q23 17q22-q23 7.765E-3 2.965E-2
1.283E-1
3.261E-1
 1 6
11 5q12 5q12 7.765E-3 2.965E-2
1.283E-1
3.261E-1
 1 6
12 5q31 5q31 9.843E-3 3.445E-2
1.491E-1
4.134E-1
 2 115
13 7q21-q22 7q21-q22 1.291E-2 4.171E-2
1.805E-1
5.422E-1
 1 10
14 12q14 12q14 1.419E-2 4.257E-2
1.842E-1
5.960E-1
 1 11
15 12q13.1 12q13.1 1.675E-2 4.690E-2
2.029E-1
7.035E-1
 1 13
16 17q21.3 17q21.3 2.058E-2 4.932E-2
2.134E-1
8.642E-1
 1 16
17 4p16 4p16 2.185E-2 4.932E-2
2.134E-1
9.176E-1
 1 17
18 5p13 5p13 2.185E-2 4.932E-2
2.134E-1
9.176E-1
 1 17
19 12q24.23 12q24.23 2.565E-2 4.932E-2
2.134E-1
1.000E0
 1 20
20 18p11.32 18p11.32 2.565E-2 4.932E-2
2.134E-1
1.000E0
 1 20
21 19q12 19q12 2.692E-2 4.932E-2
2.134E-1
1.000E0
 1 21
22 10q21.1 10q21.1 2.692E-2 4.932E-2
2.134E-1
1.000E0
 1 21
23 4q27 4q27 2.818E-2 4.932E-2
2.134E-1
1.000E0
 1 22
24 2q12.1 2q12.1 2.818E-2 4.932E-2
2.134E-1
1.000E0
 1 22
Show 19 more annotations

11: Transcription Factor Binding Site [Display Chart] 36 input genes in category / 325 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F Q6 V$E2F Q6 3.668E-6 4.272E-4 2.718E-3 1.192E-3 7 182
2 V$E2F Q4 V$E2F Q4 3.944E-6 4.272E-4 2.718E-3 1.282E-3 7 184
3 V$E2F1DP1RB 01 V$E2F1DP1RB 01 3.944E-6 4.272E-4 2.718E-3 1.282E-3 7 184
4 V$E2F Q3 V$E2F Q3 4.028E-5 2.469E-3 1.571E-2 1.309E-2 6 177
5 V$E2F1 Q6 V$E2F1 Q6 4.566E-5 2.469E-3 1.571E-2 1.484E-2 6 181
6 V$E2F1 Q4 01 V$E2F1 Q4 01 4.566E-5 2.469E-3 1.571E-2 1.484E-2 6 181
7 V$E2F Q3 01 V$E2F Q3 01 5.319E-5 2.469E-3 1.571E-2 1.729E-2 6 186
8 V$E2F 03 V$E2F 03 6.167E-5 2.506E-3 1.594E-2 2.004E-2 6 191
9 V$E2F1DP2 01 V$E2F1DP2 01 5.266E-4 1.238E-2
7.878E-2
1.712E-1
 5 184
10 V$E2F 02 V$E2F 02 5.266E-4 1.238E-2
7.878E-2
1.712E-1
 5 184
11 V$E2F Q6 01 V$E2F Q6 01 5.266E-4 1.238E-2
7.878E-2
1.712E-1
 5 184
12 V$E2F4DP2 01 V$E2F4DP2 01 5.266E-4 1.238E-2
7.878E-2
1.712E-1
 5 184
13 V$E2F1DP1 01 V$E2F1DP1 01 5.266E-4 1.238E-2
7.878E-2
1.712E-1
 5 184
14 V$E2F1 Q4 V$E2F1 Q4 5.951E-4 1.238E-2
7.878E-2
1.934E-1
 5 189
15 V$E2F4DP1 01 V$E2F4DP1 01 5.951E-4 1.238E-2
7.878E-2
1.934E-1
 5 189
16 V$E2F1 Q3 V$E2F1 Q3 6.096E-4 1.238E-2
7.878E-2
1.981E-1
 5 190
17 CCAWYNNGAAR UNKNOWN CCAWYNNGAAR UNKNOWN 6.559E-4 1.254E-2
7.979E-2
2.132E-1
 4 109
18 SGCGSSAAA V$E2F1DP2 01 SGCGSSAAA V$E2F1DP2 01 1.304E-3 2.355E-2
1.498E-1
4.239E-1
 4 131
Show 13 more annotations

12: Gene Family [Display Chart] 35 input genes in category / 29 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 960 Origin recognition complex genenames.org 1.716E-10 4.977E-9 1.972E-8 4.977E-9 4 6
2 473 Cyclins genenames.org 2.633E-7 3.818E-6 1.513E-5 7.637E-6 4 29
3 1156 X-linked mental retardation|Mitogen-activated protein kinase-activated protein kinases genenames.org 1.065E-6 1.029E-5 4.078E-5 3.088E-5 3 11
4 713 Class III Cys-based CDC25 phosphatases genenames.org 1.077E-5 7.810E-5 3.094E-4 3.124E-4 2 3
5 496 Cyclin dependent kinases genenames.org 1.645E-5 9.540E-5 3.780E-4 4.770E-4 3 26
6 982 E2F transcription factors genenames.org 9.994E-5 4.830E-4 1.914E-3 2.898E-3 2 8
7 559 WD repeat domain containing|F-box and WD repeat domain containing genenames.org 1.956E-4 8.103E-4 3.210E-3 5.672E-3 2 11
8 402 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 3.224E-4 1.169E-3 4.631E-3 9.351E-3 2 14
9 413 AAA ATPases genenames.org 4.658E-3 1.501E-2
5.947E-2
1.351E-1
 2 53
10 1338 Baculoviral IAP repeat containing|Chromosomal passenger complex genenames.org 7.673E-3 2.225E-2
8.816E-2
2.225E-1
 1 4
11 1309 BTG/Tob family genenames.org 1.149E-2 3.029E-2
1.200E-1
3.332E-1
 1 6
12 419 Ring finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing genenames.org 1.529E-2 3.411E-2
1.351E-1
4.434E-1
 1 8
13 837 SH2 domain containing|C2 tensin-type domain containing|PTEN protein phosphatases genenames.org 1.529E-2 3.411E-2
1.351E-1
4.434E-1
 1 8
Show 8 more annotations

13: Coexpression [Display Chart] 46 input genes in category / 4795 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20103679-ST3-A Human Breast Wood10 71genes CellCyle GeneSigDB 2.004E-22 4.805E-19 4.350E-18 9.610E-19 12 53
2 20103679-ST3-D Human Breast Wood10 71genes FoldChange>2 GeneSigDB 2.004E-22 4.805E-19 4.350E-18 9.610E-19 12 53
3 20548326-Table4 Human Stomach Bonelli10 61genes GeneSigDB 1.041E-21 1.664E-18 1.507E-17 4.993E-18 12 60
4 M2066 A list of known cell cycle regulated genes that was compiled from the literature by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.972E-19 9.556E-16 8.651E-15 3.823E-15 10 44
5 17699775-Table1 Human Lung Johnson07 46genes GeneSigDB 2.925E-18 2.805E-15 2.540E-14 1.403E-14 9 30
6 20103679-ST3-B Human Breast Wood10 416genes GeneSigDB 1.366E-17 1.092E-14 9.883E-14 6.550E-14 15 302
7 19695104-AF2 Human Breast Lin09 128genes GeneSigDB 1.054E-16 7.223E-14 6.539E-13 5.056E-13 10 69
8 19695104-AF1-4 Human Breast Lin09 28genes GeneSigDB 1.353E-16 8.111E-14 7.343E-13 6.489E-13 8 25
9 18786252-Table4 Human Breast Liu08 26genes GeneSigDB 1.952E-16 1.040E-13 9.414E-13 9.359E-13 8 26
10 M15510 Genes up-regulated in K562 cells (bone marrow) after treatment with dasatinib [PubChem=3062316] or imatinib [PubChem=5291]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.339E-16 2.560E-13 2.318E-12 2.560E-12 8 29
11 M5198 Genes down-regulated in quiescent vs dividing CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.209E-15 5.272E-13 4.772E-12 5.799E-12 10 87
12 16357169-SuppTable4 Human Prostate Floryk05 68genes GeneSigDB 2.091E-15 8.356E-13 7.564E-12 1.003E-11 9 58
13 19749795-Table2 Human Leukemia Ueno09 26genes GeneSigDB 2.382E-15 8.786E-13 7.953E-12 1.142E-11 7 18
14 11573962-Table3 Human Viral Sun01 27genes Cell Cycle-Related GeneSigDB 1.269E-14 4.346E-12 3.934E-11 6.085E-11 7 22
15 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.501E-14 4.798E-12 4.344E-11 7.198E-11 13 299
16 M7854 Differentially expressed genes in a panel of xenografts representing 8 common pediatric tumors compared to the normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.366E-14 7.091E-12 6.420E-11 1.135E-10 10 116
17 17145885-SuppTable2 Human Lung Kobayashi06 320genes GeneSigDB 4.731E-14 1.334E-11 1.208E-10 2.269E-10 12 247
18 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.731E-14 1.527E-11 1.382E-10 2.748E-10 12 251
19 18662380-S3-AURKA Human Breast Wirapati08 355genes AURKA Module GeneSigDB 9.057E-14 2.286E-11 2.069E-10 4.343E-10 13 344
20 20630075-AF-2 Mouse StemCell GarciaEscudero10 371genes p53 GeneSigDB 1.094E-13 2.623E-11 2.374E-10 5.245E-10 12 265
21 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v6.0) 1.564E-13 3.572E-11 3.233E-10 7.501E-10 11 200
22 17150101-TableS1h Human Breast Troester06 364genes up DOX-MCF7 GeneSigDB 2.289E-13 4.989E-11 4.516E-10 1.098E-9 12 282
23 M18506 Genes down-regulated in the ANBL-6 cell line (multiple myeloma, MM) after withdrawal of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.917E-13 5.827E-11 5.275E-10 1.399E-9 9 98
24 15705876-TableS6 Human Leukemia Passioura05 105genes GeneSigDB 2.917E-13 5.827E-11 5.275E-10 1.399E-9 9 98
25 15896717-Table7 Human Leukemia Bal05 36genes GeneSigDB 6.084E-13 1.167E-10 1.056E-9 2.917E-9 7 36
26 17150101-TableS1c Human Breast Troester06 134genes up DoxTreated-HME-CC GeneSigDB 6.560E-13 1.210E-10 1.095E-9 3.145E-9 9 107
27 17804718-Table1 Mouse Breast Deeb07 119genes GeneSigDB 7.778E-13 1.381E-10 1.250E-9 3.729E-9 9 109
28 M15606 Genes up-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.160E-13 1.569E-10 1.420E-9 4.392E-9 11 235
29 M679 G1 to S phase regulators significantly changed in DanG cells (pancreatic cancer) treated with Ly294002 [PubChem=3973], a phosphoinositide 3-kinase (PI3K) inhibitor. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.384E-12 2.288E-10 2.071E-9 6.635E-9 5 8
30 M3155 Genes up-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.136E-12 3.378E-10 3.058E-9 1.024E-8 10 181
31 M6866 Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.184E-12 3.378E-10 3.058E-9 1.047E-8 9 122
32 18713946-Table2 Human Lymphoma Sander08 27genes GeneSigDB 3.205E-12 4.803E-10 4.348E-9 1.537E-8 6 22
33 15489886-TableS1b Human Sarcoma Mason04 549genes GeneSigDB 4.004E-12 5.817E-10 5.266E-9 1.920E-8 13 464
34 15548366-Table2 Mouse Bladder Yao04 53genes GeneSigDB 5.272E-12 7.435E-10 6.731E-9 2.528E-8 7 48
35 M1915 Genes down-regulated in neural stem cells (NSC) at 60 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.467E-12 7.490E-10 6.780E-9 2.621E-8 11 277
36 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 5.779E-12 7.698E-10 6.969E-9 2.771E-8 10 200
37 M1945 Genes up-regulated in MEF cells (embryonic fibroblast) after expression of E2F1 or E2F2 [GeneID=1869;1870]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.096E-11 1.420E-9 1.285E-8 5.253E-8 7 53
38 M2515 Genes deregulated in U2OS cells (osteosarcoma) upon knockdown of BAP1 [GeneID=8314] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.020E-11 2.548E-9 2.307E-8 9.684E-8 6 29
39 M15356 Genes constituting the LIT-Int network of proteins interacting with breast cancer reference proteins BRCA1, BRCA2, ATM, and CHEK2 [GeneID=672;675;472;11200]; the interactions were manually curated from the literature. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.263E-11 2.782E-9 2.518E-8 1.085E-7 8 101
40 17145885-Table2 Human Lung Kobayashi06 42genes GeneSigDB 2.521E-11 3.022E-9 2.735E-8 1.209E-7 6 30
41 18231642-TableW1 Mouse Brain DeSmaele07 122genes GeneSigDB 3.103E-11 3.629E-9 3.285E-8 1.488E-7 8 105
42 M854 Genes whose expression profile is specific to Cluster III of urothelial cell carcinoma (UCC) tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.371E-11 3.849E-9 3.484E-8 1.617E-7 11 328
43 M2984 Genes up-regulated in B lymphocytes: control versus stimulated by anti-IgM for 12h. MSigDB C7: Immunologic Signatures (v6.0) 8.107E-11 8.931E-9 8.085E-8 3.887E-7 9 182
44 16951154-Table1 Human Prostate Ma06 42genes GeneSigDB 8.196E-11 8.931E-9 8.085E-8 3.930E-7 6 36
45 M19867 Genes down-regulated in acute myeloid leukemia (AML) with respect to cellular localization of NPM1 [GeneID=4869]: cytoplasmic vs. nucleolar. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.939E-11 9.525E-9 8.623E-8 4.286E-7 9 184
46 19351846-SuppTable3 Human Prostate Wang09 40genes GeneSigDB 9.767E-11 1.018E-8 9.217E-8 4.683E-7 6 37
47 M10739 Genes down-regulated in ANBL-6 cell line (multiple myeloma, MM) expressing a constantly active form of NRAS [GeneID=4893] off a plasmid vector compared to those grown in the presence of IL6 [GeneID=3569]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.018E-10 1.024E-8 9.269E-8 4.882E-7 7 72
48 17899371-GeneTable4 Human Breast Lauss08 374genes GeneSigDB 1.025E-10 1.024E-8 9.269E-8 4.915E-7 11 364
49 14562049-Table2 Human StemCell Young03 142genes GeneSigDB 1.355E-10 1.326E-8 1.201E-7 6.500E-7 8 126
50 19101988-TableS2 Human Breast Habermann09 18genes GeneSigDB 1.509E-10 1.447E-8 1.310E-7 7.235E-7 5 17
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 46 input genes in category / 2660 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 8.320E-16 2.213E-12 1.873E-11 2.213E-12 15 376
2 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 8.370E-14 3.054E-11 2.585E-10 2.226E-10 14 413
3 GSM399403 500 alpha beta T cells, T.ISP.Th, 4- 8+ TCR-/lo 24hi, Thymus, avg-3 Immgen.org, GSE15907 9.547E-14 3.054E-11 2.585E-10 2.539E-10 14 417
4 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Overall Top 200 Genes 1.033E-13 3.054E-11 2.585E-10 2.749E-10 11 182
5 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Top 200 BrainMap 1.033E-13 3.054E-11 2.585E-10 2.749E-10 11 182
6 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Overall Top 200 Genes BrainMap 1.033E-13 3.054E-11 2.585E-10 2.749E-10 11 182
7 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Overall Top 200 Genes BrainMap 1.033E-13 3.054E-11 2.585E-10 2.749E-10 11 182
8 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis Neurogenesis Overall Top 200 Genes BrainMap 1.033E-13 3.054E-11 2.585E-10 2.749E-10 11 182
9 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature Neurogenesis.neurons.immature Top 200 BrainMap 1.033E-13 3.054E-11 2.585E-10 2.749E-10 11 182
10 Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Erythroblast Top 200 Genes Human Cell Atlas Human Cell Atlas Erythro Erythro Subtype Erythroblast Top 200 Genes 4.138E-13 1.101E-10 9.315E-10 1.101E-9 12 280
11 GSM399452 500 B cells, preB.FrC.BM, CD19+ IgM- CD45R+ CD43+ HSA+, Bone marrow, avg-3 Immgen.org, GSE15907 1.687E-12 3.796E-10 3.213E-9 4.486E-9 13 409
12 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap 1.998E-12 3.796E-10 3.213E-9 5.314E-9 12 320
13 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 1.998E-12 3.796E-10 3.213E-9 5.314E-9 12 320
14 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes 1.998E-12 3.796E-10 3.213E-9 5.314E-9 12 320
15 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Striatum Top 200 Genes BrainMap 2.397E-12 4.250E-10 3.597E-9 6.375E-9 12 325
16 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4 Hippocampus Top 200 Genes BrainMap 5.161E-12 8.581E-10 7.262E-9 1.373E-8 12 347
17 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes 2.379E-11 3.722E-9 3.150E-8 6.328E-8 9 150
18 GSM538358 500 B cells, proB.FrBC.FL, CD19+ IgM- CD43+ CD24+ AA4.1+ CD45R+, Fetal Liver, avg-3 Immgen.org, GSE15907 2.699E-11 3.988E-9 3.375E-8 7.179E-8 12 400
19 GSM538348 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-2 Immgen.org, GSE15907 4.616E-11 6.311E-9 5.341E-8 1.228E-7 12 419
20 GSM791141 500 alpha beta T cells, preT.DN2B.Th, Lin-/lo CD25hi CD44+ cKitint, Thymus, avg-2 Immgen.org, GSE15907 4.745E-11 6.311E-9 5.341E-8 1.262E-7 12 420
21 GSM538357 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate CD45R+ AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 5.013E-11 6.349E-9 5.374E-8 1.333E-7 12 422
22 GSM791131 500 B cells, MLP.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R- CD, Fetal Liver, avg-3 Immgen.org, GSE15907 5.440E-11 6.577E-9 5.566E-8 1.447E-7 12 425
23 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis Tabula Muris Consortium 2.073E-10 2.287E-8 1.936E-7 5.515E-7 9 191
24 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/Slamf1-positive multipotent progenitor cell Tabula Muris Consortium 2.073E-10 2.287E-8 1.936E-7 5.515E-7 9 191
25 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Top 200 BrainMap 2.150E-10 2.287E-8 1.936E-7 5.718E-7 12 479
26 GSM605781 500 gamma delta T cells, Tgd.vg1+vd6-.Th, TCRd+ Vg1.1+, Thymus, avg-3 Immgen.org, GSE15907 2.445E-10 2.502E-8 2.118E-7 6.505E-7 11 373
27 10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-T cell CD4 - B Top 200 Genes 4.136E-10 4.075E-8 3.449E-7 1.100E-6 11 392
28 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 4.728E-10 4.492E-8 3.802E-7 1.258E-6 11 397
29 GSM538354 500 B cells, proB.FrA.BM, AA4.1+ CD117+ IL7R+ CD45R+ CD24- CD19- IgM-, Bone marrow, avg-1 Immgen.org, GSE15907 6.196E-10 5.683E-8 4.810E-7 1.648E-6 10 304
30 GSM538387 500 alpha beta T cells, T.8Eff.Sp.OT1.d5.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 6.640E-10 5.887E-8 4.983E-7 1.766E-6 11 410
31 GSM538350 500 B cells, proB.CLP.FL, CD19- IgM- CD43+ CD24intermediate CD45R- AA4.1+ CD, Fetal Liver, avg-1 Immgen.org, GSE15907 8.136E-10 6.981E-8 5.909E-7 2.164E-6 11 418
32 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Dlx1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Polydendrocyte/Polydendrocyte/Bmp4 C1q/Tnr//Dlx1 BrainMap 8.618E-10 7.109E-8 6.016E-7 2.292E-6 8 150
33 GSM538355 500 B cells, proB.FrA.FL, CD19- IgM- CD43+ CD24intermediate AA4.1+ CD45R+ CD, Fetal Liver, avg-2 Immgen.org, GSE15907 8.992E-10 7.109E-8 6.016E-7 2.392E-6 11 422
34 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.1 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.1 Top 100 Genes 9.086E-10 7.109E-8 6.016E-7 2.417E-6 8 151
35 6mo cortical organoids wt 6mo cortical organoids wt nan static Subtype 6 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt nan static Subtype 6 Top 100 Genes 1.101E-9 8.366E-8 7.080E-7 2.928E-6 7 95
36 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Overall Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Overall Top 100 Genes 1.474E-9 1.089E-7 9.216E-7 3.920E-6 7 99
37 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.0.4 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.0.4 Top 100 Genes 1.927E-9 1.385E-7 1.172E-6 5.125E-6 8 166
38 BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Dlx1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr Subtype Polydendrocyte.polydendrocytes.Bmp4 C1q.Tnr.Dlx1 Top 200 Genes BrainMap 2.221E-9 1.555E-7 1.316E-6 5.907E-6 10 347
39 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ Lymphoid UNK Top 200 Genes 2.397E-9 1.635E-7 1.384E-6 6.376E-6 9 252
40 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 3.766E-9 2.505E-7 2.120E-6 1.002E-5 11 484
41 Lungmap Mouse Lung PND3 Immune Subtype Immune-C Lungmap Mouse Lung PND3 Immune Subtype Immune-C Lungmap CCHMC 4.381E-9 2.842E-7 2.405E-6 1.165E-5 9 270
42 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/pre-natural killer cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/pre-natural killer cell Tabula Muris Consortium 4.532E-9 2.870E-7 2.429E-6 1.205E-5 8 185
43 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mitotic BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mitotic BrainMap 5.143E-9 3.181E-7 2.692E-6 1.368E-5 8 188
44 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/late pro-B cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/late pro-B cell Tabula Muris Consortium 5.362E-9 3.241E-7 2.743E-6 1.426E-5 8 189
45 Cap mesenchyme (CM)/Cap mesenchyme (CM) f Cap mesenchyme (CM)/Cap mesenchyme (CM) f 7.724E-9 4.566E-7 3.864E-6 2.055E-5 8 198
46 GSM399450 500 B cells, proB.FrBC.BM, CD19+ IgM- CD43+ AA4.1+ CD45R+, Bone marrow, avg-2 Immgen.org, GSE15907 9.059E-9 5.238E-7 4.434E-6 2.410E-5 10 402
47 GSM605793 500 gamma delta T cells, Tgd.vg2+24ahi.Th.TCRbko, TCRd+ Vg2+ CD24+, Thymus, avg-3 Immgen.org, GSE15907 1.144E-8 6.474E-7 5.479E-6 3.043E-5 10 412
48 GSM476660 500 gamma delta T cells, Tgd.vg2+24ahi.e17.Th, TCRd+ Vg2+ CD24+, Fetal Thymus, avg-3 Immgen.org, GSE15907 1.198E-8 6.637E-7 5.617E-6 3.186E-5 10 414
49 GSM791136 500 alpha beta T cells, preT.DN2.Th, Lin-/lo CD25hi CD44+ cKit+, Thymus, avg-3 Immgen.org, GSE15907 1.373E-8 7.451E-7 6.307E-6 3.651E-5 10 420
50 GSM476658 500 gamma delta T cells, Tgd.vg2-24ahi.Th, TCRd+ Vg2- CD24+, Thymus, avg-2 Immgen.org, GSE15907 1.436E-8 7.638E-7 6.465E-6 3.819E-5 10 422
Show 45 more annotations

15: Computational [Display Chart] 42 input genes in category / 262 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M582 MODULE 57 Genes in the cancer module 57. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.569E-20 6.731E-18 4.138E-17 6.731E-18 13 56
2 M16174 MODULE 124 Transcription. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.708E-9 6.168E-7 3.791E-6 1.234E-6 8 96
3 M5468 MODULE 54 Cell cycle (expression cluster). MSigDb: C4 - CM: Cancer Modules (v6.0) 8.720E-8 6.744E-6 4.146E-5 2.285E-5 10 262
4 M17151 GNF2 CDC20 Neighborhood of CDC20 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.030E-7 6.744E-6 4.146E-5 2.698E-5 6 56
5 M5444 GNF2 RFC4 Neighborhood of RFC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.568E-7 8.217E-6 5.052E-5 4.109E-5 6 60
6 M7419 GNF2 CCNA2 Neighborhood of CCNA2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.345E-7 1.461E-5 8.979E-5 8.764E-5 6 68
7 M11526 MODULE 308 Pol II transcription. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.336E-7 1.623E-5 9.978E-5 1.136E-4 6 71
8 M4092 MODULE 197 Genes in the cancer module 197. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.959E-7 1.624E-5 9.983E-5 1.299E-4 8 174
9 M11613 GNF2 RRM2 Neighborhood of RRM2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.927E-7 1.725E-5 1.061E-4 1.553E-4 5 40
10 M5265 GNF2 CENPE Neighborhood of CENPE MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.729E-7 1.763E-5 1.084E-4 1.763E-4 5 41
11 M12521 GNF2 HMMR Neighborhood of HMMR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.352E-6 3.221E-5 1.980E-4 3.543E-4 5 47
12 M3537 GNF2 CKS2 Neighborhood of CKS2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.850E-6 4.040E-5 2.484E-4 4.848E-4 5 50
13 M15766 GNF2 CCNB2 Neighborhood of CCNB2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.579E-6 7.213E-5 4.434E-4 9.377E-4 5 57
14 M112 GNF2 H2AFX Neighborhood of H2AFX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.678E-6 1.437E-4 8.834E-4 2.012E-3 4 31
15 M17279 GNF2 PCNA Neighborhood of PCNA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.614E-6 1.505E-4 9.249E-4 2.257E-3 5 68
16 M7614 MODULE 126 Lymphoma and immune response expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.395E-6 1.530E-4 9.404E-4 2.461E-3 7 183
17 M6962 GNF2 SMC2L1 Neighborhood of SMC2L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.925E-6 1.530E-4 9.404E-4 2.600E-3 4 33
18 M4598 GNF2 TTK Neighborhood of TTK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.959E-5 2.852E-4 1.753E-3 5.133E-3 4 39
19 M13406 GNF2 RFC3 Neighborhood of RFC3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.398E-5 3.306E-4 2.032E-3 6.281E-3 4 41
20 M11786 GNF2 RRM1 Neighborhood of RRM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.044E-5 3.988E-4 2.451E-3 7.975E-3 5 88
21 M5464 MODULE 403 DNA damage response. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.805E-5 4.747E-4 2.918E-3 9.970E-3 4 46
22 M17030 MODULE 312 Viral anti-apoptotic evasion mechanisms. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.147E-5 4.938E-4 3.036E-3 1.086E-2 4 47
23 M4550 MODULE 252 TFs and nuclear. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.993E-5 5.687E-4 3.496E-3 1.308E-2 7 237
24 M14325 GNF2 FEN1 Neighborhood of FEN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.309E-5 9.012E-4 5.540E-3 2.177E-2 4 56
25 M7114 MODULE 439 Genes in the cancer module 439. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.599E-5 9.012E-4 5.540E-3 2.253E-2 3 21
26 M667 MODULE 254 Genes in the cancer module 254. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.090E-4 1.098E-3 6.752E-3 2.856E-2 4 60
27 M13566 GNF2 CDC2 Neighborhood of CDC2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.239E-4 1.160E-3 7.129E-3 3.247E-2 4 62
28 M10439 GNF2 CENPF Neighborhood of CENPF MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.239E-4 1.160E-3 7.129E-3 3.247E-2 4 62
29 M7629 GNF2 BUB1 Neighborhood of BUB1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.657E-4 1.497E-3 9.202E-3 4.341E-2 3 26
30 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.884E-4 1.645E-3 1.011E-2 4.935E-2 8 393
31 M6132 GNF2 MKI67 Neighborhood of MKI67 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.075E-4 1.754E-3 1.078E-2
5.438E-2
 3 28
32 M10327 MODULE 451 Genes in the cancer module 451. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.407E-4 2.789E-3 1.715E-2
8.925E-2
 3 33
33 M12856 GNF2 SMC4L1 Neighborhood of SMC4L1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.011E-4 3.131E-3 1.925E-2
1.051E-1
 4 84
34 M664 GNF2 ESPL1 Neighborhood of ESPL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.063E-4 3.131E-3 1.925E-2
1.064E-1
 3 35
35 M10065 GNF2 CKS1B Neighborhood of CKS1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.795E-4 3.590E-3 2.207E-2
1.256E-1
 3 37
36 M4409 MODULE 17 Genes in the cancer module 17. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.365E-4 5.360E-3 3.295E-2
1.930E-1
 7 367
37 M9199 MODULE 3 Genes in the cancer module 3. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.767E-4 6.916E-3 4.251E-2
2.559E-1
 7 385
38 M8616 MORF GSPT1 Neighborhood of GSPT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.098E-3 7.377E-3 4.535E-2
2.877E-1
 3 49
39 M8304 GNF2 BUB1B Neighborhood of BUB1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.098E-3 7.377E-3 4.535E-2
2.877E-1
 3 49
40 M17594 GNF2 MCM4 Neighborhood of MCM4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.380E-3 8.922E-3
5.485E-2
3.616E-1
 3 53
41 M6479 MODULE 105 Genes in the cancer module 105. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.396E-3 8.922E-3
5.485E-2
3.658E-1
 5 200
42 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.512E-3 9.430E-3
5.797E-2
3.960E-1
 6 303
43 M5597 MODULE 315 Spindle and kinetochore. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.977E-3 1.204E-2
7.403E-2
5.178E-1
 2 16
44 M15619 MODULE 18 Genes in the cancer module 18. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.429E-3 1.446E-2
8.892E-2
6.364E-1
 7 451
45 M218 GNF2 PA2G4 Neighborhood of PA2G4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.321E-3 2.516E-2
1.546E-1
1.000E0
 3 79
46 M17027 MODULE 573 Cell cycle regulators and carbohydrate transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.825E-3 2.748E-2
1.689E-1
1.000E0
 2 25
47 M7895 MORF SOD1 Neighborhood of SOD1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.698E-3 3.176E-2
1.953E-1
1.000E0
 5 277
48 M3615 MODULE 303 Genes in the cancer module 303. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.031E-3 3.292E-2
2.024E-1
1.000E0
 2 28
49 M19433 MODULE 488 Growth inhibitory genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.461E-3 3.455E-2
2.124E-1
1.000E0
 2 29
50 M949 MODULE 244 Response to DNA damage. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.518E-3 3.939E-2
2.422E-1
1.000E0
 4 187
Show 45 more annotations

16: MicroRNA [Display Chart] 46 input genes in category / 2046 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-497-5p:Functional MTI Functional MTI miRTarbase 6.762E-15 1.384E-11 1.135E-10 1.384E-11 11 460
2 hsa-miR-503-5p:Functional MTI Functional MTI miRTarbase 2.680E-10 2.742E-7 2.249E-6 5.484E-7 7 251
3 hsa-miR-424-5p:Functional MTI Functional MTI miRTarbase 6.463E-10 4.408E-7 3.615E-6 1.322E-6 8 471
4 hsa-miR-6838-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.122E-8 4.876E-6 3.999E-5 2.297E-5 7 431
5 hsa-miR-646:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.381E-8 4.876E-6 3.999E-5 2.827E-5 6 251
6 hsa-miR-103a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.578E-8 4.876E-6 3.999E-5 3.228E-5 7 453
7 hsa-miR-34b-5p:Functional MTI Functional MTI miRTarbase 1.709E-8 4.876E-6 3.999E-5 3.496E-5 5 123
8 hsa-miR-29a-3p:Functional MTI Functional MTI miRTarbase 1.907E-8 4.876E-6 3.999E-5 3.901E-5 6 265
9 hsa-miR-449b-5p:Functional MTI Functional MTI miRTarbase 3.271E-8 7.436E-6 6.098E-5 6.692E-5 5 140
10 hsa-miR-3663-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.156E-8 1.055E-5 8.651E-5 1.055E-4 4 56
11 hsa-miR-449a:Functional MTI Functional MTI miRTarbase 6.576E-8 1.223E-5 1.003E-4 1.345E-4 5 161
12 hsa-miR-326:TargetScan hsa-miR-326 TargetScan 1.344E-7 2.116E-5 1.735E-4 2.751E-4 6 369
13 hsa-miR-330-5p:TargetScan hsa-miR-330-5p TargetScan 1.344E-7 2.116E-5 1.735E-4 2.751E-4 6 369
14 hsa-miR-203a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.602E-7 2.341E-5 1.920E-4 3.277E-4 4 74
15 hsa-miR-4709-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.531E-7 4.816E-5 3.949E-4 7.224E-4 4 90
16 hsa-miR-212-3p:Functional MTI Functional MTI miRTarbase 4.206E-7 5.378E-5 4.411E-4 8.605E-4 4 94
17 hsa-miR-145-5p:Functional MTI Functional MTI miRTarbase 4.568E-7 5.498E-5 4.509E-4 9.347E-4 5 238
18 hsa-miR-636:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.613E-7 6.380E-5 5.232E-4 1.148E-3 4 101
19 hsa-miR-302c-3p.2:TargetScan hsa-miR-302c-3p.2 TargetScan 7.198E-7 7.364E-5 6.039E-4 1.473E-3 6 492
20 hsa-miR-520f-3p:TargetScan hsa-miR-520f-3p TargetScan 7.198E-7 7.364E-5 6.039E-4 1.473E-3 6 492
21 hsa-miR-2682-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.903E-7 7.700E-5 6.315E-4 1.617E-3 4 110
22 hsa-miR-449c-5p:Functional MTI Functional MTI miRTarbase 8.802E-7 8.186E-5 6.713E-4 1.801E-3 4 113
23 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 1.070E-6 9.283E-5 7.613E-4 2.190E-3 5 283
24 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 1.089E-6 9.283E-5 7.613E-4 2.228E-3 5 284
25 hsa-miR-107:Functional MTI Functional MTI miRTarbase 1.424E-6 1.166E-4 9.559E-4 2.914E-3 5 300
26 hsa-miR-196a-5p:Functional MTI Functional MTI miRTarbase 1.495E-6 1.177E-4 9.649E-4 3.059E-3 5 303
27 hsa-miR-499a-5p:TargetScan hsa-miR-499a-5p TargetScan 1.780E-6 1.349E-4 1.106E-3 3.642E-3 5 314
28 hsa-miR-624-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.007E-6 1.411E-4 1.157E-3 4.105E-3 3 38
29 hsa-miR-942:PITA hsa-miR-942:PITA TOP PITA 2.043E-6 1.411E-4 1.157E-3 4.180E-3 5 323
30 hsa-miR-4477a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.069E-6 1.411E-4 1.157E-3 4.234E-3 4 140
31 hsa-miR-421:PITA hsa-miR-421:PITA TOP PITA 3.236E-6 2.136E-4 1.752E-3 6.622E-3 5 355
32 hsa-miR-152-3p:Functional MTI Functional MTI miRTarbase 3.346E-6 2.139E-4 1.754E-3 6.845E-3 4 158
33 hsa-miR-1248:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.786E-6 2.278E-4 1.868E-3 7.745E-3 4 163
34 hsa-miR-22-3p:Functional MTI Functional MTI miRTarbase 3.786E-6 2.278E-4 1.868E-3 7.745E-3 4 163
35 hsa-miR-3665:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.902E-6 2.711E-4 2.223E-3 1.003E-2 4 174
36 hsa-miR-142-3p:Functional MTI Functional MTI miRTarbase 5.044E-6 2.711E-4 2.223E-3 1.032E-2 5 389
37 hsa-miR-379:mirSVR highEffct hsa-miR-379:mirSVR conserved highEffect-0.5 MicroRNA.org 5.107E-6 2.711E-4 2.223E-3 1.045E-2 5 390
38 hsa-miR-590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.107E-6 2.711E-4 2.223E-3 1.045E-2 5 390
39 hsa-miR-101-3p:Functional MTI Functional MTI miRTarbase 5.300E-6 2.711E-4 2.223E-3 1.084E-2 5 393
40 hsa-miR-103:PITA hsa-miR-103:PITA TOP PITA 5.432E-6 2.711E-4 2.223E-3 1.111E-2 5 395
41 hsa-miR-107:PITA hsa-miR-107:PITA TOP PITA 5.432E-6 2.711E-4 2.223E-3 1.111E-2 5 395
42 hsa-miR-6859-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.855E-6 2.754E-4 2.259E-3 1.198E-2 4 182
43 hsa-miR-3125:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.983E-6 2.754E-4 2.259E-3 1.224E-2 4 183
44 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 5.985E-6 2.754E-4 2.259E-3 1.225E-2 5 403
45 hsa-miR-6740-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.193E-6 2.754E-4 2.259E-3 1.267E-2 3 55
46 hsa-miR-3137:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.193E-6 2.754E-4 2.259E-3 1.267E-2 3 55
47 hsa-miR-3916:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.516E-6 2.837E-4 2.326E-3 1.333E-2 4 187
48 hsa-miR-4524b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.795E-6 2.837E-4 2.327E-3 1.390E-2 4 189
49 hsa-miR-4524a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.795E-6 2.837E-4 2.327E-3 1.390E-2 4 189
50 hsa-miR-1229-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.274E-6 2.976E-4 2.441E-3 1.488E-2 3 58
Show 45 more annotations

17: Drug [Display Chart] 46 input genes in category / 11304 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C500026 palbociclib CTD 4.685E-25 5.296E-21 5.248E-20 5.296E-21 17 171
2 CID003033957 silydianin Stitch 1.268E-23 7.166E-20 7.101E-19 1.433E-19 11 28
3 CID000441764 silychristin Stitch 2.040E-23 7.686E-20 7.616E-19 2.306E-19 11 29
4 CID003085830 isosilybin B Stitch 7.575E-23 2.141E-19 2.121E-18 8.562E-19 11 32
5 CID000072271 UCN-01 Stitch 2.985E-18 6.748E-15 6.688E-14 3.374E-14 13 154
6 CID000005097 NSC683246 Stitch 1.702E-17 3.206E-14 3.177E-13 1.924E-13 14 234
7 CID000003862 mimosine Stitch 9.549E-16 1.542E-12 1.528E-11 1.079E-11 11 125
8 ctd:C531937 6-O-angeloylenolin CTD 1.595E-15 2.254E-12 2.233E-11 1.803E-11 7 17
9 ctd:C471405 sorafenib CTD 6.867E-15 8.624E-12 8.547E-11 7.762E-11 11 149
10 ctd:D020123 Sirolimus CTD 7.863E-15 8.888E-12 8.808E-11 8.888E-11 15 458
11 ctd:C482884 panduratin A CTD 9.480E-15 9.742E-12 9.654E-11 1.072E-10 7 21
12 ctd:C077990 alvocidib CTD 1.610E-14 1.516E-11 1.503E-10 1.820E-10 9 71
13 CID000003721 AC1L1GK8 Stitch 3.057E-14 2.658E-11 2.634E-10 3.456E-10 9 76
14 CID000003657 hydroxyurea Stitch 1.015E-13 8.192E-11 8.118E-10 1.147E-9 14 438
15 ctd:C440975 silybin CTD 2.223E-13 1.675E-10 1.660E-9 2.513E-9 9 94
16 CID000005213 silibinin Stitch 3.014E-13 2.129E-10 2.110E-9 3.407E-9 12 285
17 CID000006035 bromodeoxyuridine Stitch 3.304E-13 2.197E-10 2.177E-9 3.735E-9 13 376
18 ctd:C494914 3,5,3',4',5'-pentamethoxystilbene CTD 3.749E-13 2.354E-10 2.333E-9 4.238E-9 6 16
19 CID005287969 flavopiridol Stitch 4.182E-13 2.431E-10 2.409E-9 4.727E-9 11 216
20 CID009547890 N6-9 Stitch 4.301E-13 2.431E-10 2.409E-9 4.862E-9 7 34
21 CID005317025 linarin Stitch 5.542E-13 2.983E-10 2.956E-9 6.265E-9 5 7
22 ctd:C008493 methylselenic acid CTD 1.085E-12 5.574E-10 5.524E-9 1.226E-8 13 413
23 ctd:C479128 HS 1200 CTD 1.264E-12 6.215E-10 6.159E-9 1.429E-8 6 19
24 CID000499953 phorbol-13-acetate Stitch 1.472E-12 6.672E-10 6.613E-9 1.664E-8 12 326
25 ctd:C094299 ZD 9331 CTD 1.476E-12 6.672E-10 6.613E-9 1.668E-8 5 8
26 ctd:D008012 Lidocaine CTD 1.943E-12 8.159E-10 8.086E-9 2.197E-8 8 74
27 ctd:D012835 Silver Nitrate CTD 1.949E-12 8.159E-10 8.086E-9 2.203E-8 9 119
28 ctd:C022830 2-methoxyestradiol CTD 2.131E-12 8.605E-10 8.527E-9 2.409E-8 7 42
29 ctd:C403899 HS 1030 CTD 3.315E-12 1.292E-9 1.281E-8 3.748E-8 5 9
30 CID000119307 ginsenoside Rh2 Stitch 3.569E-12 1.345E-9 1.333E-8 4.034E-8 7 45
31 CID000004592 olomoucine Stitch 5.016E-12 1.829E-9 1.813E-8 5.670E-8 9 132
32 ctd:C403900 HS 1183 CTD 6.621E-12 2.339E-9 2.318E-8 7.484E-8 5 10
33 ctd:C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one CTD 1.702E-11 5.759E-9 5.707E-8 1.924E-7 12 402
34 ctd:C587734 2,3,5-trichloro-6-phenyl-(1,4)benzoquinone CTD 1.732E-11 5.759E-9 5.707E-8 1.958E-7 6 28
35 ctd:C060540 polyhexamethyleneguanidine CTD 1.910E-11 6.168E-9 6.112E-8 2.159E-7 9 153
36 CID005316907 dineolignan Stitch 2.075E-11 6.338E-9 6.281E-8 2.345E-7 5 12
37 CID000164503 asiminacin Stitch 2.075E-11 6.338E-9 6.281E-8 2.345E-7 5 12
38 ctd:C044985 1',2'-dihydrorotenone CTD 3.366E-11 1.001E-8 9.923E-8 3.805E-7 5 13
39 CID000005637 U0126 Stitch 3.814E-11 1.105E-8 1.095E-7 4.311E-7 12 431
40 ctd:C553817 7-(benzylamino)-1,3,4,8-tetrahydropyrrolo(4,3,2-de)quinolin-8(1H)-one CTD 4.002E-11 1.131E-8 1.121E-7 4.524E-7 8 107
41 ctd:D019438 Ritonavir CTD 4.651E-11 1.282E-8 1.271E-7 5.257E-7 8 109
42 ctd:C113580 U 0126 CTD 5.374E-11 1.446E-8 1.433E-7 6.075E-7 12 444
43 ctd:D048789 Phytoestrogens CTD 6.618E-11 1.740E-8 1.724E-7 7.481E-7 7 67
44 CID005005498 alsterpaullone Stitch 7.385E-11 1.807E-8 1.790E-7 8.348E-7 6 35
45 ctd:C102351 apicidin CTD 7.385E-11 1.807E-8 1.790E-7 8.348E-7 6 35
46 ctd:C058956 acteoside CTD 7.385E-11 1.807E-8 1.790E-7 8.348E-7 6 35
47 ctd:C016392 3,3'-diindolylmethane CTD 7.697E-11 1.807E-8 1.790E-7 8.701E-7 8 116
48 ctd:C120275 2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone CTD 7.831E-11 1.807E-8 1.790E-7 8.852E-7 5 15
49 ctd:C503536 HS-1199 CTD 7.831E-11 1.807E-8 1.790E-7 8.852E-7 5 15
50 ctd:C007845 gingerol CTD 9.082E-11 2.053E-8 2.035E-7 1.027E-6 7 70
Show 45 more annotations

18: Disease [Display Chart] 46 input genes in category / 1275 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0334634 Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse DisGeNET Curated 7.404E-12 9.440E-9 7.296E-8 9.440E-9 13 343
2 C1868684 EAR, PATELLA, SHORT STATURE SYNDROME DisGeNET Curated 3.295E-8 2.101E-5 1.623E-4 4.201E-5 5 33
3 C0006413 Burkitt Lymphoma DisGeNET Curated 1.238E-6 3.432E-4 2.653E-3 1.578E-3 9 390
4 C0278488 Carcinoma breast stage IV DisGeNET BeFree 1.238E-6 3.432E-4 2.653E-3 1.578E-3 9 390
5 C0002893 Refractory anemias DisGeNET Curated 1.346E-6 3.432E-4 2.653E-3 1.716E-3 8 289
6 C0334317 Cystadenofibroma DisGeNET BeFree 1.777E-6 3.776E-4 2.918E-3 2.265E-3 3 9
7 C0521720 Corneal fibrosis DisGeNET BeFree 2.533E-6 4.614E-4 3.566E-3 3.230E-3 3 10
8 C0206624 Hepatoblastoma DisGeNET Curated 3.439E-6 5.481E-4 4.236E-3 4.385E-3 7 229
9 C0024301 Lymphoma, Follicular DisGeNET Curated 5.457E-6 7.731E-4 5.975E-3 6.958E-3 8 349
10 C0023492 Leukemia, T-Cell DisGeNET Curated 6.184E-6 7.885E-4 6.094E-3 7.885E-3 8 355
11 C0279702 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Curated 8.389E-6 9.724E-4 7.515E-3 1.070E-2 9 493
12 C0238198 Gastrointestinal Stromal Tumors DisGeNET Curated 1.013E-5 1.076E-3 8.317E-3 1.291E-2 7 270
13 C1961099 Precursor T-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 1.251E-5 1.168E-3 9.028E-3 1.594E-2 8 391
14 C0175754 Agenesis of corpus callosum DisGeNET Curated 1.283E-5 1.168E-3 9.028E-3 1.635E-2 7 280
15 C3273239 Proliferative Inflammatory Atrophy DisGeNET BeFree 1.416E-5 1.203E-3 9.300E-3 1.805E-2 3 17
16 C0280803 Primary central nervous system lymphoma DisGeNET BeFree 1.620E-5 1.291E-3 9.975E-3 2.065E-2 4 54
17 C0555198 Malignant Glioma DisGeNET BeFree 2.564E-5 1.923E-3 1.486E-2 3.269E-2 8 432
18 C0036220 Kaposi Sarcoma DisGeNET Curated 3.215E-5 2.278E-3 1.760E-2 4.100E-2 7 323
19 C0376545 Hematologic Neoplasms DisGeNET Curated 5.261E-5 3.417E-3 2.640E-2
6.708E-2
 8 478
20 C0205748 Dysplastic Nevus DisGeNET Curated 5.359E-5 3.417E-3 2.640E-2
6.833E-2
 4 73
21 C0679427 myeloblastosis DisGeNET BeFree 6.673E-5 4.010E-3 3.099E-2
8.507E-2
 3 28
22 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 6.919E-5 4.010E-3 3.099E-2
8.821E-2
 8 497
23 C1969653 MUNGAN SYNDROME DisGeNET Curated 7.840E-5 4.165E-3 3.219E-2
9.997E-2
 2 5
24 C0677866 Brain Stem Neoplasms DisGeNET Curated 7.840E-5 4.165E-3 3.219E-2
9.997E-2
 2 5
25 C0853879 Invasive carcinoma of breast DisGeNET BeFree 9.739E-5 4.758E-3 3.677E-2
1.242E-1
 7 385
26 C0032580 Adenomatous Polyposis Coli DisGeNET Curated 9.898E-5 4.758E-3 3.677E-2
1.262E-1
 7 386
27 C0751396 Well Differentiated Oligodendroglioma DisGeNET BeFree 1.007E-4 4.758E-3 3.677E-2
1.285E-1
 5 165
28 C0028945 oligodendroglioma DisGeNET Curated 1.097E-4 4.994E-3 3.860E-2
1.398E-1
 5 168
29 C1855650 Birth length less than 3rd percentile DisGeNET Curated 1.174E-4 5.161E-3 3.989E-2
1.497E-1
 2 6
30 C1314694 Astrocytoma, low grade DisGeNET BeFree 1.555E-4 6.537E-3
5.052E-2
1.982E-1
 3 37
31 C0027831 Neurofibromatosis 1 DisGeNET Curated 1.638E-4 6.537E-3
5.052E-2
2.088E-1
 5 183
32 C1864954 Hyperinsulinemia, fasting DisGeNET Curated 1.641E-4 6.537E-3
5.052E-2
2.092E-1
 2 7
33 C0282160 Aplasia Cutis Congenita DisGeNET Curated 2.048E-4 7.630E-3
5.897E-2
2.612E-1
 5 192
34 C0153381 Malignant neoplasm of mouth DisGeNET BeFree 2.131E-4 7.630E-3
5.897E-2
2.717E-1
 7 437
35 C4018860 Pituitary growth hormone cell adenoma DisGeNET Curated 2.183E-4 7.630E-3
5.897E-2
2.784E-1
 2 8
36 C0079772 T-Cell Lymphoma DisGeNET Curated 2.218E-4 7.630E-3
5.897E-2
2.828E-1
 6 308
37 C0220641 Lip and Oral Cavity Carcinoma DisGeNET BeFree 2.222E-4 7.630E-3
5.897E-2
2.833E-1
 7 440
38 C1336527 Carcinoma of urinary bladder, superficial DisGeNET BeFree 2.274E-4 7.630E-3
5.897E-2
2.899E-1
 3 42
39 C0263454 Chloracne DisGeNET Curated 2.440E-4 7.976E-3
6.164E-2
3.111E-1
 3 43
40 C3808022 Abdominal pain, episodic DisGeNET Curated 2.802E-4 8.507E-3
6.574E-2
3.573E-1
 2 9
41 C0262527 intermittent abdominal pain DisGeNET Curated 2.802E-4 8.507E-3
6.574E-2
3.573E-1
 2 9
42 C1403035 Subcutaneous lipomas DisGeNET Curated 2.802E-4 8.507E-3
6.574E-2
3.573E-1
 2 9
43 C0854917 Rhabdoid Tumor of the Kidney DisGeNET BeFree 2.983E-4 8.846E-3
6.836E-2
3.804E-1
 3 46
44 C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 3.233E-4 9.370E-3
7.241E-2
4.123E-1
 7 468
45 C0220668 Congenital contractural arachnodactyly DisGeNET Curated 3.310E-4 9.378E-3
7.248E-2
4.220E-1
 5 213
46 C1336548 Systemic Anaplastic Large Cell Lymphoma DisGeNET BeFree 3.496E-4 9.595E-3
7.415E-2
4.458E-1
 2 10
47 C1378703 Renal carcinoma DisGeNET Curated 3.537E-4 9.595E-3
7.415E-2
4.510E-1
 7 475
48 C0023470 Myeloid Leukemia DisGeNET Curated 3.960E-4 1.052E-2
8.130E-2
5.050E-1
 7 484
49 C0008479 Chondrosarcoma DisGeNET Curated 4.705E-4 1.224E-2
9.461E-2
5.999E-1
 5 230
50 C0025500 Mesothelioma DisGeNET Curated 4.880E-4 1.244E-2
9.617E-2
6.222E-1
 6 357
Show 45 more annotations