Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc13_187, positive side

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1: GO: Molecular Function [Display Chart] 185 input genes in category / 382 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005125 cytokine activity 9.569E-31 3.655E-28 2.385E-27 3.655E-28 34 222
2 GO:0005126 cytokine receptor binding 2.920E-29 5.578E-27 3.639E-26 1.116E-26 36 289
3 GO:0004896 cytokine receptor activity 6.860E-25 8.735E-23 5.699E-22 2.621E-22 22 90
4 GO:0019955 cytokine binding 3.953E-19 3.775E-17 2.463E-16 1.510E-16 19 103
5 GO:0001618 virus receptor activity 2.788E-16 2.130E-14 1.389E-13 1.065E-13 15 71
6 GO:0008009 chemokine activity 3.212E-14 2.045E-12 1.334E-11 1.227E-11 12 48
7 GO:0042379 chemokine receptor binding 5.818E-13 3.175E-11 2.071E-10 2.223E-10 12 60
8 GO:0003823 antigen binding 9.461E-13 4.518E-11 2.947E-10 3.614E-10 15 120
9 GO:0048020 CCR chemokine receptor binding 7.453E-11 3.163E-9 2.064E-8 2.847E-8 9 37
10 GO:0015026 coreceptor activity 2.560E-10 9.779E-9 6.379E-8 9.779E-8 9 42
11 GO:0070851 growth factor receptor binding 1.823E-9 6.330E-8 4.130E-7 6.963E-7 13 143
12 GO:0005031 tumor necrosis factor-activated receptor activity 2.521E-9 6.889E-8 4.494E-7 9.631E-7 7 24
13 GO:0005035 death receptor activity 2.521E-9 6.889E-8 4.494E-7 9.631E-7 7 24
14 GO:0050839 cell adhesion molecule binding 2.525E-9 6.889E-8 4.494E-7 9.645E-7 15 208
15 GO:0005178 integrin binding 3.345E-8 8.518E-7 5.557E-6 1.278E-5 11 121
16 GO:0019956 chemokine binding 4.197E-8 1.002E-6 6.538E-6 1.603E-5 6 21
17 GO:0001664 G protein-coupled receptor binding 1.114E-7 2.504E-6 1.634E-5 4.257E-5 15 276
18 GO:0001637 G protein-coupled chemoattractant receptor activity 1.325E-7 2.665E-6 1.738E-5 5.063E-5 6 25
19 GO:0004950 chemokine receptor activity 1.325E-7 2.665E-6 1.738E-5 5.063E-5 6 25
20 GO:0005527 macrolide binding 9.424E-7 1.714E-5 1.118E-4 3.600E-4 5 19
21 GO:0005528 FK506 binding 9.424E-7 1.714E-5 1.118E-4 3.600E-4 5 19
22 GO:0019960 C-X3-C chemokine binding 9.448E-6 1.569E-4 1.024E-3 3.609E-3 3 5
23 GO:0005143 interleukin-12 receptor binding 9.448E-6 1.569E-4 1.024E-3 3.609E-3 3 5
24 GO:0035004 phosphatidylinositol 3-kinase activity 1.125E-5 1.791E-4 1.168E-3 4.299E-3 7 77
25 GO:0019838 growth factor binding 1.226E-5 1.837E-4 1.198E-3 4.682E-3 9 142
26 GO:0042287 MHC protein binding 1.250E-5 1.837E-4 1.198E-3 4.776E-3 5 31
27 GO:0005164 tumor necrosis factor receptor binding 1.719E-5 2.432E-4 1.586E-3 6.565E-3 5 33
28 GO:0050840 extracellular matrix binding 1.883E-5 2.569E-4 1.676E-3 7.194E-3 6 56
29 GO:0045236 CXCR chemokine receptor binding 2.012E-5 2.650E-4 1.729E-3 7.685E-3 4 17
30 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 3.394E-5 4.322E-4 2.820E-3 1.297E-2 6 62
31 GO:0008201 heparin binding 4.440E-5 5.472E-4 3.570E-3 1.696E-2 9 167
32 GO:0042608 T cell receptor binding 5.176E-5 5.991E-4 3.909E-3 1.977E-2 3 8
33 GO:0071723 lipopeptide binding 5.176E-5 5.991E-4 3.909E-3 1.977E-2 3 8
34 GO:0008144 drug binding 6.408E-5 7.199E-4 4.697E-3 2.448E-2 8 136
35 GO:0052813 phosphatidylinositol bisphosphate kinase activity 7.949E-5 8.675E-4 5.660E-3 3.036E-2 6 72
36 GO:0019865 immunoglobulin binding 8.507E-5 9.027E-4 5.889E-3 3.250E-2 4 24
37 GO:0019972 interleukin-12 binding 9.776E-5 9.108E-4 5.942E-3 3.734E-2 2 2
38 GO:0045518 interleukin-22 receptor binding 9.776E-5 9.108E-4 5.942E-3 3.734E-2 2 2
39 GO:0031729 CCR4 chemokine receptor binding 9.776E-5 9.108E-4 5.942E-3 3.734E-2 2 2
40 GO:0004920 interleukin-10 receptor activity 9.776E-5 9.108E-4 5.942E-3 3.734E-2 2 2
41 GO:0045523 interleukin-27 receptor binding 9.776E-5 9.108E-4 5.942E-3 3.734E-2 2 2
42 GO:0032813 tumor necrosis factor receptor superfamily binding 1.339E-4 1.218E-3 7.944E-3
5.114E-2
 5 50
43 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1.473E-4 1.295E-3 8.450E-3
5.625E-2
 5 51
44 GO:0046790 virion binding 1.492E-4 1.295E-3 8.450E-3
5.699E-2
 3 11
45 GO:0016859 cis-trans isomerase activity 1.770E-4 1.503E-3 9.804E-3
6.763E-2
 5 53
46 GO:0016493 C-C chemokine receptor activity 2.548E-4 2.116E-3 1.381E-2
9.734E-2
 3 13
47 GO:1901681 sulfur compound binding 2.776E-4 2.226E-3 1.452E-2
1.060E-1
 10 260
48 GO:0030369 ICAM-3 receptor activity 2.914E-4 2.226E-3 1.452E-2
1.113E-1
 2 3
49 GO:0035663 Toll-like receptor 2 binding 2.914E-4 2.226E-3 1.452E-2
1.113E-1
 2 3
50 GO:0031735 CCR10 chemokine receptor binding 2.914E-4 2.226E-3 1.452E-2
1.113E-1
 2 3
Show 45 more annotations

2: GO: Biological Process [Display Chart] 186 input genes in category / 3189 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070661 leukocyte proliferation 8.436E-59 2.690E-55 2.326E-54 2.690E-55 59 320
2 GO:0046651 lymphocyte proliferation 6.656E-56 1.061E-52 9.175E-52 2.123E-52 56 301
3 GO:0032943 mononuclear cell proliferation 1.203E-55 1.279E-52 1.106E-51 3.837E-52 56 304
4 GO:0051249 regulation of lymphocyte activation 1.075E-52 8.572E-50 7.410E-49 3.429E-49 61 445
5 GO:0002250 adaptive immune response 2.789E-51 1.553E-48 1.342E-47 8.895E-48 58 402
6 GO:0002696 positive regulation of leukocyte activation 2.921E-51 1.553E-48 1.342E-47 9.315E-48 55 341
7 GO:0050867 positive regulation of cell activation 2.495E-50 1.137E-47 9.826E-47 7.957E-47 55 354
8 GO:0070663 regulation of leukocyte proliferation 6.255E-50 2.494E-47 2.156E-46 1.995E-46 48 233
9 GO:0050670 regulation of lymphocyte proliferation 1.442E-49 5.110E-47 4.417E-46 4.599E-46 47 221
10 GO:0032944 regulation of mononuclear cell proliferation 2.284E-49 7.283E-47 6.296E-46 7.283E-46 47 223
11 GO:1903037 regulation of leukocyte cell-cell adhesion 1.974E-48 5.723E-46 4.948E-45 6.295E-45 53 341
12 GO:0050863 regulation of T cell activation 5.098E-48 1.355E-45 1.171E-44 1.626E-44 52 327
13 GO:0051251 positive regulation of lymphocyte activation 8.985E-48 2.204E-45 1.905E-44 2.865E-44 51 311
14 GO:0050671 positive regulation of lymphocyte proliferation 1.216E-47 2.770E-45 2.394E-44 3.877E-44 40 141
15 GO:0001819 positive regulation of cytokine production 1.412E-47 3.002E-45 2.596E-44 4.504E-44 56 418
16 GO:0032946 positive regulation of mononuclear cell proliferation 2.314E-47 4.612E-45 3.987E-44 7.379E-44 40 143
17 GO:0022407 regulation of cell-cell adhesion 7.089E-47 1.330E-44 1.150E-43 2.261E-43 56 430
18 GO:0034110 regulation of homotypic cell-cell adhesion 1.465E-46 2.513E-44 2.172E-43 4.671E-43 52 348
19 GO:0070665 positive regulation of leukocyte proliferation 1.497E-46 2.513E-44 2.172E-43 4.775E-43 40 149
20 GO:0034109 homotypic cell-cell adhesion 7.317E-46 1.167E-43 1.009E-42 2.333E-42 54 402
21 GO:0042098 T cell proliferation 1.523E-45 2.312E-43 1.999E-42 4.856E-42 44 215
22 GO:0022409 positive regulation of cell-cell adhesion 1.008E-44 1.462E-42 1.264E-41 3.216E-41 47 276
23 GO:0045785 positive regulation of cell adhesion 1.547E-44 2.145E-42 1.854E-41 4.934E-41 54 425
24 GO:1903039 positive regulation of leukocyte cell-cell adhesion 2.699E-43 3.587E-41 3.101E-40 8.608E-40 44 240
25 GO:0050870 positive regulation of T cell activation 1.349E-42 1.721E-40 1.487E-39 4.302E-39 43 231
26 GO:0034112 positive regulation of homotypic cell-cell adhesion 3.584E-42 4.396E-40 3.800E-39 1.143E-38 43 236
27 GO:0042129 regulation of T cell proliferation 4.355E-42 5.143E-40 4.446E-39 1.389E-38 39 173
28 GO:0050900 leukocyte migration 1.557E-41 1.773E-39 1.533E-38 4.964E-38 50 386
29 GO:0042102 positive regulation of T cell proliferation 5.963E-39 6.558E-37 5.669E-36 1.902E-35 32 107
30 GO:0002697 regulation of immune effector process 1.181E-38 1.256E-36 1.086E-35 3.767E-35 51 466
31 GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 1.858E-36 1.912E-34 1.653E-33 5.926E-33 41 275
32 GO:0002237 response to molecule of bacterial origin 2.052E-35 2.045E-33 1.768E-32 6.544E-32 44 358
33 GO:0002703 regulation of leukocyte mediated immunity 5.611E-35 5.422E-33 4.688E-32 1.789E-31 35 184
34 GO:0032609 interferon-gamma production 6.845E-35 6.420E-33 5.550E-32 2.183E-31 31 125
35 GO:0032649 regulation of interferon-gamma production 9.002E-35 8.202E-33 7.090E-32 2.871E-31 30 113
36 GO:0030098 lymphocyte differentiation 2.860E-34 2.534E-32 2.191E-31 9.122E-31 43 356
37 GO:0002699 positive regulation of immune effector process 1.917E-33 1.653E-31 1.429E-30 6.114E-30 34 185
38 GO:0002443 leukocyte mediated immunity 4.940E-33 4.146E-31 3.584E-30 1.575E-29 42 356
39 GO:0032496 response to lipopolysaccharide 1.603E-32 1.310E-30 1.133E-29 5.111E-29 41 342
40 GO:0002366 leukocyte activation involved in immune response 1.979E-32 1.578E-30 1.364E-29 6.310E-29 36 235
41 GO:0042089 cytokine biosynthetic process 2.611E-32 2.031E-30 1.756E-29 8.326E-29 29 120
42 GO:0002263 cell activation involved in immune response 2.710E-32 2.057E-30 1.779E-29 8.641E-29 36 237
43 GO:0042107 cytokine metabolic process 4.431E-32 3.286E-30 2.841E-29 1.413E-28 29 122
44 GO:0042035 regulation of cytokine biosynthetic process 1.453E-30 1.053E-28 9.106E-28 4.635E-27 27 108
45 GO:0042108 positive regulation of cytokine biosynthetic process 1.308E-29 9.270E-28 8.014E-27 4.172E-26 23 68
46 GO:0030217 T cell differentiation 3.823E-29 2.650E-27 2.291E-26 1.219E-25 34 245
47 GO:0032729 positive regulation of interferon-gamma production 1.829E-28 1.241E-26 1.073E-25 5.834E-25 23 75
48 GO:1902105 regulation of leukocyte differentiation 2.004E-27 1.331E-25 1.151E-24 6.391E-24 34 275
49 GO:0046634 regulation of alpha-beta T cell activation 6.622E-27 4.310E-25 3.726E-24 2.112E-23 23 86
50 GO:0002274 myeloid leukocyte activation 1.231E-26 7.850E-25 6.786E-24 3.925E-23 29 183
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 186 input genes in category / 213 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0009897 external side of plasma membrane 5.951E-73 1.268E-70 7.530E-70 1.268E-70 67 310
2 GO:0043235 receptor complex 1.069E-24 1.138E-22 6.761E-22 2.276E-22 34 339
3 GO:0098802 plasma membrane receptor complex 1.923E-24 1.365E-22 8.110E-22 4.096E-22 27 180
4 GO:0098636 protein complex involved in cell adhesion 1.557E-13 6.633E-12 3.941E-11 3.317E-11 10 30
5 GO:0008305 integrin complex 1.557E-13 6.633E-12 3.941E-11 3.317E-11 10 30
6 GO:0042101 T cell receptor complex 4.874E-12 1.730E-10 1.028E-9 1.038E-9 8 19
7 GO:0001772 immunological synapse 3.748E-11 1.141E-9 6.776E-9 7.984E-9 9 35
8 GO:0042105 alpha-beta T cell receptor complex 4.357E-8 1.160E-6 6.891E-6 9.280E-6 4 5
9 GO:0045121 membrane raft 2.708E-7 5.769E-6 3.427E-5 5.769E-5 16 343
10 GO:0098857 membrane microdomain 2.708E-7 5.769E-6 3.427E-5 5.769E-5 16 343
11 GO:0036020 endolysosome membrane 4.088E-6 7.916E-5 4.702E-4 8.707E-4 4 12
12 GO:0031092 platelet alpha granule membrane 5.860E-6 1.040E-4 6.179E-4 1.248E-3 4 13
13 GO:0030139 endocytic vesicle 1.191E-5 1.951E-4 1.159E-3 2.537E-3 12 265
14 GO:0036019 endolysosome 1.892E-5 2.878E-4 1.710E-3 4.029E-3 4 17
15 GO:0045335 phagocytic vesicle 2.454E-5 3.484E-4 2.070E-3 5.226E-3 7 88
16 GO:0005911 cell-cell junction 6.447E-5 8.583E-4 5.099E-3 1.373E-2 14 418
17 GO:0043514 interleukin-12 complex 9.471E-5 1.187E-3 7.050E-3 2.017E-2 2 2
18 GO:0005925 focal adhesion 1.336E-4 1.581E-3 9.390E-3 2.845E-2 13 393
19 GO:0005924 cell-substrate adherens junction 1.513E-4 1.696E-3 1.008E-2 3.223E-2 13 398
20 GO:0030055 cell-substrate junction 1.710E-4 1.822E-3 1.082E-2 3.643E-2 13 403
21 GO:0071062 alphav-beta3 integrin-vitronectin complex 2.823E-4 2.733E-3 1.624E-2
6.013E-2
 2 3
22 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex 2.823E-4 2.733E-3 1.624E-2
6.013E-2
 2 3
23 GO:0005912 adherens junction 2.960E-4 2.741E-3 1.629E-2
6.305E-2
 14 484
24 GO:0019815 B cell receptor complex 5.610E-4 4.979E-3 2.958E-2
1.195E-1
 2 4
25 GO:0005771 multivesicular body 1.040E-3 8.578E-3
5.096E-2
2.216E-1
 4 46
26 GO:0045177 apical part of cell 1.047E-3 8.578E-3
5.096E-2
2.230E-1
 12 428
27 GO:0032009 early phagosome 1.385E-3 1.053E-2
6.257E-2
2.949E-1
 2 6
28 GO:0046696 lipopolysaccharide receptor complex 1.385E-3 1.053E-2
6.257E-2
2.949E-1
 2 6
29 GO:0016324 apical plasma membrane 1.721E-3 1.264E-2
7.511E-2
3.666E-1
 10 335
30 GO:0030667 secretory granule membrane 1.795E-3 1.275E-2
7.572E-2
3.824E-1
 5 89
31 GO:0045178 basal part of cell 3.535E-3 2.429E-2
1.443E-1
7.530E-1
 4 64
32 GO:0030666 endocytic vesicle membrane 4.328E-3 2.881E-2
1.711E-1
9.218E-1
 6 156
33 GO:0031225 anchored component of membrane 4.892E-3 3.158E-2
1.876E-1
1.000E0
 6 160
34 GO:0010008 endosome membrane 5.941E-3 3.522E-2
2.093E-1
1.000E0
 10 399
35 GO:0098852 lytic vacuole membrane 5.953E-3 3.522E-2
2.093E-1
1.000E0
 8 277
36 GO:0005765 lysosomal membrane 5.953E-3 3.522E-2
2.093E-1
1.000E0
 8 277
37 GO:0031091 platelet alpha granule 6.225E-3 3.584E-2
2.129E-1
1.000E0
 4 75
38 GO:0009925 basal plasma membrane 8.473E-3 4.749E-2
2.822E-1
1.000E0
 3 43
39 GO:0042022 interleukin-12 receptor complex 9.758E-3 4.834E-2
2.872E-1
1.000E0
 1 1
40 GO:0005898 interleukin-13 receptor complex 9.758E-3 4.834E-2
2.872E-1
1.000E0
 1 1
41 GO:0061474 phagolysosome membrane 9.758E-3 4.834E-2
2.872E-1
1.000E0
 1 1
42 GO:0036053 glomerular endothelium fenestra 9.758E-3 4.834E-2
2.872E-1
1.000E0
 1 1
43 GO:0034676 integrin alpha6-beta4 complex 9.758E-3 4.834E-2
2.872E-1
1.000E0
 1 1
Show 38 more annotations

4: Human Phenotype [Display Chart] 67 input genes in category / 1759 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003346 Abnormal immunological laboratory finding 1.923E-22 3.383E-19 2.723E-18 3.383E-19 34 330
2 HP:0040088 Abnormal lymphocyte count 4.799E-20 4.221E-17 3.398E-16 8.442E-17 22 115
3 HP:0012140 Abnormality of cells of the lymphoid lineage 8.663E-19 5.080E-16 4.089E-15 1.524E-15 31 336
4 HP:0001888 Lymphopenia 3.978E-18 1.749E-15 1.408E-14 6.997E-15 30 325
5 HP:0002843 Abnormal T cell morphology 1.570E-17 5.524E-15 4.447E-14 2.762E-14 24 189
6 HP:0002721 Immunodeficiency 1.111E-16 3.256E-14 2.621E-13 1.954E-13 33 462
7 HP:0002733 Abnormality of the lymph nodes 1.657E-16 4.164E-14 3.352E-13 2.915E-13 27 284
8 HP:0002014 Diarrhea 2.281E-16 5.016E-14 4.038E-13 4.013E-13 32 439
9 HP:0030332 Abnormal T cell morphology 5.324E-16 9.366E-14 7.539E-13 9.366E-13 15 57
10 HP:0011839 Abnormal T cell count 5.324E-16 9.366E-14 7.539E-13 9.366E-13 15 57
11 HP:0002037 Inflammation of the large intestine 6.643E-16 9.827E-14 7.911E-13 1.168E-12 23 198
12 HP:0002718 Recurrent bacterial infections 7.093E-16 9.827E-14 7.911E-13 1.248E-12 25 247
13 HP:0004435 Hypergammaglobulinemia 7.822E-16 9.827E-14 7.911E-13 1.376E-12 19 118
14 HP:0002852 Hyperglobulinemia 7.822E-16 9.827E-14 7.911E-13 1.376E-12 19 118
15 HP:0001882 Leukopenia 9.320E-16 1.093E-13 8.798E-13 1.639E-12 30 394
16 HP:0010701 Abnormal immunoglobulin level 1.435E-15 1.485E-13 1.195E-12 2.524E-12 26 281
17 HP:0100032 Immunoglobulin abnormality 1.435E-15 1.485E-13 1.195E-12 2.524E-12 26 281
18 HP:0005372 Abnormality of B cell physiology 1.567E-15 1.531E-13 1.232E-12 2.756E-12 26 282
19 HP:0005403 Decrease in T cell count 2.123E-15 1.966E-13 1.582E-12 3.735E-12 14 50
20 HP:0004386 Gastrointestinal inflammation 2.658E-15 2.338E-13 1.882E-12 4.676E-12 25 261
21 HP:0002716 Lymphadenopathy 1.002E-14 8.396E-13 6.758E-12 1.763E-11 25 276
22 HP:0002958 Immune dysregulation 1.313E-14 1.050E-12 8.453E-12 2.310E-11 16 84
23 HP:0001370 Rheumatoid arthritis 9.839E-14 7.525E-12 6.057E-11 1.731E-10 20 174
24 HP:0100827 Lymphocytosis 1.449E-13 1.062E-11 8.552E-11 2.550E-10 17 115
25 HP:0011123 Inflammatory abnormality of the skin 3.028E-13 2.131E-11 1.715E-10 5.327E-10 28 416
26 HP:0001974 Leukocytosis 1.790E-12 1.211E-10 9.750E-10 3.149E-9 23 284
27 HP:0005368 Abnormality of humoral immunity 2.489E-12 1.622E-10 1.306E-9 4.379E-9 26 383
28 HP:0005523 Lymphoproliferative disorder 2.821E-12 1.772E-10 1.427E-9 4.963E-9 18 159
29 HP:0001973 Autoimmune thrombocytopenia 3.551E-12 2.099E-10 1.690E-9 6.247E-9 17 139
30 HP:0002846 Abnormal B cell morphology 3.580E-12 2.099E-10 1.690E-9 6.297E-9 26 389
31 HP:0000979 Purpura 3.905E-12 2.216E-10 1.784E-9 6.869E-9 18 162
32 HP:0011122 Abnormality of skin physiology 4.662E-12 2.563E-10 2.063E-9 8.200E-9 28 464
33 HP:0001025 Urticaria 4.997E-12 2.664E-10 2.144E-9 8.791E-9 14 84
34 HP:0010702 Increased antibody level in blood 5.911E-12 3.058E-10 2.462E-9 1.040E-8 19 190
35 HP:0002665 Lymphoma 1.401E-11 7.040E-10 5.667E-9 2.464E-8 24 345
36 HP:0006527 Lymphoid interstitial pneumonia 1.651E-11 8.069E-10 6.495E-9 2.905E-8 12 59
37 HP:0031409 Abnormal lymphocyte physiology 1.962E-11 9.328E-10 7.509E-9 3.451E-8 16 132
38 HP:0030057 Autoimmune antibody positivity 2.121E-11 9.817E-10 7.903E-9 3.730E-8 14 93
39 HP:0000964 Eczema 2.745E-11 1.238E-9 9.965E-9 4.828E-8 19 207
40 HP:0003496 Increased IgM level 3.768E-11 1.657E-9 1.334E-8 6.627E-8 12 63
41 HP:0005435 Impaired T cell function 4.412E-11 1.893E-9 1.524E-8 7.762E-8 13 80
42 HP:0002633 Vasculitis 5.376E-11 2.251E-9 1.812E-8 9.456E-8 19 215
43 HP:0001945 Fever 9.406E-11 3.848E-9 3.097E-8 1.654E-7 27 486
44 HP:0011840 Abnormality of T cell physiology 1.066E-10 4.263E-9 3.432E-8 1.876E-7 15 125
45 HP:0100281 Chronic colitis 1.886E-10 7.211E-9 5.805E-8 3.317E-7 15 130
46 HP:0002583 Colitis 1.886E-10 7.211E-9 5.805E-8 3.317E-7 15 130
47 HP:0100280 Crohn's disease 2.189E-10 8.191E-9 6.594E-8 3.850E-7 14 110
48 HP:0003493 Antinuclear antibody positivity 2.801E-10 1.027E-8 8.264E-8 4.927E-7 11 58
49 HP:0003249 Genital ulcers 4.065E-10 1.459E-8 1.175E-7 7.150E-7 9 33
50 HP:0000155 Oral ulcer 7.297E-10 2.567E-8 2.066E-7 1.283E-6 10 48
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 165 input genes in category / 2570 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020174 abnormal IgG level 6.427E-45 1.652E-41 1.392E-40 1.652E-41 62 411
2 MP:0001844 autoimmune response 1.921E-38 2.155E-35 1.817E-34 4.936E-35 57 419
3 MP:0005005 abnormal self tolerance 2.516E-38 2.155E-35 1.817E-34 6.466E-35 57 421
4 MP:0005000 abnormal immune tolerance 7.297E-38 4.688E-35 3.952E-34 1.875E-34 57 429
5 MP:0008555 abnormal interferon secretion 1.883E-36 9.680E-34 8.159E-33 4.840E-33 50 320
6 MP:0008559 abnormal interferon-gamma secretion 6.991E-36 2.995E-33 2.524E-32 1.797E-32 47 277
7 MP:0002425 altered susceptibility to autoimmune disorder 1.901E-35 6.980E-33 5.884E-32 4.886E-32 50 335
8 MP:0002460 decreased immunoglobulin level 5.368E-35 1.646E-32 1.387E-31 1.380E-31 50 342
9 MP:0002493 increased IgG level 6.086E-35 1.646E-32 1.387E-31 1.564E-31 43 226
10 MP:0002461 increased immunoglobulin level 6.404E-35 1.646E-32 1.387E-31 1.646E-31 49 325
11 MP:0020176 abnormal IgG2a level 1.064E-34 2.485E-32 2.095E-31 2.734E-31 38 160
12 MP:0020175 abnormal IgG1 level 1.337E-34 2.863E-32 2.413E-31 3.435E-31 43 230
13 MP:0002406 increased susceptibility to infection 1.572E-34 3.107E-32 2.619E-31 4.039E-31 55 449
14 MP:0013802 abnormal IgG2 level 2.147E-34 3.849E-32 3.245E-31 5.518E-31 41 203
15 MP:0008835 abnormal intercellular signaling peptide or protein level 2.247E-34 3.849E-32 3.245E-31 5.774E-31 55 452
16 MP:0008713 abnormal cytokine level 5.920E-34 9.509E-32 8.015E-31 1.521E-30 54 439
17 MP:0008073 abnormal CD4-positive, alpha beta T cell number 1.812E-33 2.739E-31 2.308E-30 4.656E-30 55 470
18 MP:0001805 decreased IgG level 2.182E-33 3.116E-31 2.627E-30 5.609E-30 44 261
19 MP:0008568 abnormal interleukin secretion 2.830E-32 3.828E-30 3.227E-29 7.274E-29 55 495
20 MP:0005350 increased susceptibility to autoimmune disorder 1.815E-30 2.332E-28 1.965E-27 4.663E-27 37 189
21 MP:0005463 abnormal CD4-positive, alpha-beta T cell physiology 1.977E-29 2.419E-27 2.039E-26 5.080E-26 35 172
22 MP:0008495 decreased IgG1 level 1.708E-26 1.995E-24 1.682E-23 4.389E-23 31 148
23 MP:0001828 abnormal T cell activation 2.525E-26 2.821E-24 2.378E-23 6.488E-23 44 379
24 MP:0005094 abnormal T cell proliferation 3.075E-26 3.293E-24 2.776E-23 7.903E-23 42 339
25 MP:0008750 abnormal interferon level 1.903E-25 1.956E-23 1.649E-22 4.890E-22 29 132
26 MP:0002145 abnormal T cell differentiation 3.469E-25 3.429E-23 2.890E-22 8.915E-22 45 426
27 MP:0005351 decreased susceptibility to autoimmune disorder 1.664E-24 1.584E-22 1.335E-21 4.277E-21 33 202
28 MP:0013803 increased IgG2 level 2.506E-24 2.300E-22 1.939E-21 6.440E-21 26 105
29 MP:0008751 abnormal interleukin level 2.847E-24 2.523E-22 2.127E-21 7.318E-21 38 296
30 MP:0013701 abnormal mature B cell number 1.072E-23 9.185E-22 7.743E-21 2.756E-20 41 370
31 MP:0005014 increased B cell number 1.629E-23 1.351E-21 1.139E-20 4.188E-20 39 331
32 MP:0008567 decreased interferon-gamma secretion 4.272E-23 3.431E-21 2.892E-20 1.098E-19 30 173
33 MP:0008566 increased interferon-gamma secretion 6.168E-23 4.804E-21 4.049E-20 1.585E-19 27 131
34 MP:0012765 decreased alpha-beta T cell number 2.394E-22 1.810E-20 1.525E-19 6.153E-19 41 401
35 MP:0002498 abnormal acute inflammation 3.248E-22 2.369E-20 1.997E-19 8.347E-19 38 337
36 MP:0002339 abnormal lymph node morphology 3.318E-22 2.369E-20 1.997E-19 8.527E-19 42 428
37 MP:0008075 decreased CD4-positive, alpha beta T cell number 4.646E-22 3.227E-20 2.720E-19 1.194E-18 37 319
38 MP:0020184 altered susceptibility to parasitic infection 6.147E-22 4.157E-20 3.504E-19 1.580E-18 26 128
39 MP:0020180 abnormal IgM level 7.185E-22 4.735E-20 3.991E-19 1.847E-18 33 243
40 MP:0008074 increased CD4-positive, alpha beta T cell number 1.217E-21 7.816E-20 6.589E-19 3.127E-18 33 247
41 MP:0008500 increased IgG2a level 1.524E-21 9.551E-20 8.051E-19 3.916E-18 22 82
42 MP:0002409 decreased susceptibility to infection 2.178E-21 1.333E-19 1.123E-18 5.597E-18 30 197
43 MP:0010210 abnormal circulating cytokine level 2.335E-21 1.396E-19 1.176E-18 6.002E-18 37 334
44 MP:0012764 increased alpha-beta T cell number 3.392E-21 1.981E-19 1.670E-18 8.718E-18 36 316
45 MP:0020173 abnormal IgE level 5.692E-21 3.251E-19 2.740E-18 1.463E-17 27 154
46 MP:0009785 altered susceptibility to infection induced morbidity/mortality 1.014E-20 5.665E-19 4.775E-18 2.606E-17 29 190
47 MP:0004392 abnormal CD8-positive, alpha-beta T cell physiology 1.654E-20 9.042E-19 7.621E-18 4.250E-17 24 116
48 MP:0008496 decreased IgG2a level 2.423E-20 1.297E-18 1.093E-17 6.226E-17 22 92
49 MP:0020186 altered susceptibility to bacterial infection 3.021E-20 1.585E-18 1.336E-17 7.765E-17 36 337
50 MP:0013804 decreased IgG2 level 3.877E-20 1.993E-18 1.680E-17 9.965E-17 24 120
Show 45 more annotations

6: Domain [Display Chart] 185 input genes in category / 553 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS50835 IG LIKE PROSITE 2.370E-35 1.311E-32 9.035E-32 1.311E-32 49 492
2 IPR003599 Ig sub InterPro 4.474E-29 8.247E-27 5.685E-26 2.474E-26 41 421
3 SM00409 IG SMART 4.474E-29 8.247E-27 5.685E-26 2.474E-26 41 421
4 PF07686 V-set Pfam 9.741E-18 1.347E-15 9.284E-15 5.387E-15 22 185
5 IPR013106 Ig V-set InterPro 5.280E-17 5.840E-15 4.026E-14 2.920E-14 22 200
6 SM00199 SCY SMART 5.124E-15 4.722E-13 3.255E-12 2.833E-12 12 42
7 IPR018184 Integrin alpha C CS InterPro 7.912E-15 5.902E-13 4.069E-12 4.375E-12 9 16
8 PF00048 IL8 Pfam 9.606E-15 5.902E-13 4.069E-12 5.312E-12 12 44
9 IPR001811 Chemokine IL8-like dom InterPro 9.606E-15 5.902E-13 4.069E-12 5.312E-12 12 44
10 IPR032695 Integrin dom InterPro 1.984E-14 1.097E-12 7.563E-12 1.097E-11 10 25
11 PS00242 INTEGRIN ALPHA PROSITE 3.306E-14 1.306E-12 9.001E-12 1.828E-11 9 18
12 PF08441 Integrin alpha2 Pfam 3.306E-14 1.306E-12 9.001E-12 1.828E-11 9 18
13 IPR013649 Integrin alpha-2 InterPro 3.306E-14 1.306E-12 9.001E-12 1.828E-11 9 18
14 IPR000413 Integrin alpha InterPro 3.306E-14 1.306E-12 9.001E-12 1.828E-11 9 18
15 PF00047 ig Pfam 4.585E-14 1.585E-12 1.092E-11 2.536E-11 19 190
16 IPR013151 Immunoglobulin InterPro 4.585E-14 1.585E-12 1.092E-11 2.536E-11 19 190
17 SM00191 Int alpha SMART 6.228E-14 1.913E-12 1.319E-11 3.444E-11 9 19
18 IPR013519 Int alpha beta-p InterPro 6.228E-14 1.913E-12 1.319E-11 3.444E-11 9 19
19 SM00255 TIR SMART 1.948E-13 5.670E-12 3.909E-11 1.077E-10 9 21
20 PF01582 TIR Pfam 3.269E-13 8.609E-12 5.934E-11 1.808E-10 9 22
21 PS51470 FG GAP PROSITE 3.269E-13 8.609E-12 5.934E-11 1.808E-10 9 22
22 3.40.50.10140 - Gene3D 5.325E-13 1.339E-11 9.228E-11 2.945E-10 9 23
23 PS50104 TIR PROSITE 8.449E-13 1.869E-11 1.288E-10 4.672E-10 9 24
24 IPR013517 FG-GAP InterPro 8.449E-13 1.869E-11 1.288E-10 4.672E-10 9 24
25 PF01839 FG-GAP Pfam 8.449E-13 1.869E-11 1.288E-10 4.672E-10 9 24
26 IPR000157 TIR dom InterPro 1.309E-12 2.784E-11 1.919E-10 7.238E-10 9 25
27 PF00357 Integrin alpha Pfam 2.608E-12 5.341E-11 3.682E-10 1.442E-9 7 11
28 PF02189 ITAM Pfam 5.935E-12 1.132E-10 7.802E-10 3.282E-9 6 7
29 SM00077 ITAM SMART 5.935E-12 1.132E-10 7.802E-10 3.282E-9 6 7
30 IPR018503 Tetraspanin CS InterPro 1.416E-11 2.610E-10 1.799E-9 7.831E-9 8 21
31 PS00472 SMALL CYTOKINES CC PROSITE 1.042E-10 1.747E-9 1.204E-8 5.764E-8 8 26
32 IPR000827 Chemokine CC CS InterPro 1.042E-10 1.747E-9 1.204E-8 5.764E-8 8 26
33 PS00421 TM4 1 PROSITE 1.042E-10 1.747E-9 1.204E-8 5.764E-8 8 26
34 IPR003110 Phos immunorcpt sig ITAM InterPro 1.737E-10 2.745E-9 1.892E-8 9.606E-8 6 10
35 PS51055 ITAM 1 PROSITE 1.737E-10 2.745E-9 1.892E-8 9.606E-8 6 10
36 IPR020423 IL-10 CS InterPro 5.294E-10 7.507E-9 5.175E-8 2.928E-7 5 6
37 PS00520 INTERLEUKIN 10 PROSITE 5.294E-10 7.507E-9 5.175E-8 2.928E-7 5 6
38 IPR020443 IL-10/19/20/22/24/26 fam InterPro 5.294E-10 7.507E-9 5.175E-8 2.928E-7 5 6
39 IPR000098 IL-10 InterPro 5.294E-10 7.507E-9 5.175E-8 2.928E-7 5 6
40 IPR000301 Tetraspanin InterPro 6.671E-10 8.784E-9 6.055E-8 3.689E-7 8 32
41 IPR008952 Tetraspanin EC2 InterPro 6.671E-10 8.784E-9 6.055E-8 3.689E-7 8 32
42 PF01463 LRRCT Pfam 6.671E-10 8.784E-9 6.055E-8 3.689E-7 8 32
43 PF00335 Tetraspannin Pfam 8.732E-10 1.098E-8 7.566E-8 4.829E-7 8 33
44 IPR018499 Tetraspanin/Peripherin InterPro 8.732E-10 1.098E-8 7.566E-8 4.829E-7 8 33
45 1.20.1250.10 - Gene3D 1.298E-9 1.596E-8 1.100E-7 7.180E-7 9 50
46 IPR012351 4 helix cytokine core InterPro 1.563E-9 1.879E-8 1.296E-7 8.645E-7 9 51
47 PF13895 Ig 2 Pfam 2.505E-9 2.947E-8 2.032E-7 1.385E-6 10 73
48 IPR009079 4 helix cytokine-like core InterPro 2.872E-9 3.308E-8 2.281E-7 1.588E-6 10 74
49 SM00208 TNFR SMART 4.586E-9 5.176E-8 3.568E-7 2.536E-6 7 26
50 PS00652 TNFR NGFR 1 PROSITE 1.061E-8 1.151E-7 7.933E-7 5.869E-6 7 29
Show 45 more annotations

7: Pathway [Display Chart] 175 input genes in category / 650 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83051 Cytokine-cytokine receptor interaction BioSystems: KEGG 7.975E-54 5.184E-51 3.657E-50 5.184E-51 58 270
2 83078 Hematopoietic cell lineage BioSystems: KEGG 1.203E-42 3.909E-40 2.758E-39 7.817E-40 36 97
3 1470924 Interleukin-10 signaling BioSystems: REACTOME 5.954E-25 1.290E-22 9.101E-22 3.870E-22 20 49
4 1269201 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell BioSystems: REACTOME 3.069E-21 4.988E-19 3.519E-18 1.995E-18 25 136
5 M6705 Th1/Th2 Differentiation MSigDB C2 BIOCARTA (v6.0) 1.344E-20 1.747E-18 1.233E-17 8.737E-18 13 19
6 83077 Jak-STAT signaling pathway BioSystems: KEGG 1.031E-19 1.117E-17 7.879E-17 6.700E-17 25 156
7 M6231 NO2-dependent IL 12 Pathway in NK cells MSigDB C2 BIOCARTA (v6.0) 2.368E-19 1.825E-17 1.287E-16 1.539E-16 12 17
8 M9177 Dendritic cells in regulating TH1 and TH2 Development MSigDB C2 BIOCARTA (v6.0) 2.376E-19 1.825E-17 1.287E-16 1.544E-16 13 22
9 83069 Cell adhesion molecules (CAMs) BioSystems: KEGG 2.671E-19 1.825E-17 1.287E-16 1.736E-16 24 145
10 1470923 Interleukin-4 and 13 signaling BioSystems: REACTOME 2.808E-19 1.825E-17 1.287E-16 1.825E-16 22 114
11 842771 Inflammatory bowel disease (IBD) BioSystems: KEGG 5.313E-19 3.140E-17 2.215E-16 3.454E-16 18 65
12 137922 IL12-mediated signaling events BioSystems: Pathway Interaction Database 4.664E-18 2.526E-16 1.782E-15 3.032E-15 17 61
13 P00036 Interleukin signaling pathway PantherDB 2.258E-17 1.129E-15 7.966E-15 1.468E-14 19 92
14 M4047 Selective expression of chemokine receptors during T-cell polarization MSigDB C2 BIOCARTA (v6.0) 2.977E-17 1.382E-15 9.750E-15 1.935E-14 13 29
15 M6427 T Helper Cell Surface Molecules MSigDB C2 BIOCARTA (v6.0) 2.218E-16 9.009E-15 6.356E-14 1.441E-13 10 14
16 M13247 T Cytotoxic Cell Surface Molecules MSigDB C2 BIOCARTA (v6.0) 2.218E-16 9.009E-15 6.356E-14 1.441E-13 10 14
17 M5883 Genes encoding secreted soluble factors MSigDB C2 BIOCARTA (v6.0) 7.036E-16 2.690E-14 1.898E-13 4.574E-13 30 344
18 PW:0000234 innate immune response Pathway Ontology 9.357E-16 3.379E-14 2.384E-13 6.082E-13 9 11
19 137936 IL12 signaling mediated by STAT4 BioSystems: Pathway Interaction Database 1.018E-15 3.483E-14 2.457E-13 6.618E-13 12 28
20 152665 Malaria BioSystems: KEGG 3.063E-15 9.953E-14 7.022E-13 1.991E-12 14 49
21 M4319 IL12 and Stat4 Dependent Signaling Pathway in Th1 Development MSigDB C2 BIOCARTA (v6.0) 3.604E-15 1.093E-13 7.708E-13 2.343E-12 11 23
22 M7298 Antigen Dependent B Cell Activation MSigDB C2 BIOCARTA (v6.0) 3.698E-15 1.093E-13 7.708E-13 2.404E-12 9 12
23 213306 Measles BioSystems: KEGG 3.334E-14 9.423E-13 6.648E-12 2.167E-11 19 134
24 1269547 Chemokine receptors bind chemokines BioSystems: REACTOME 6.715E-14 1.794E-12 1.266E-11 4.365E-11 13 48
25 83076 Toll-like receptor signaling pathway BioSystems: KEGG 7.093E-14 1.794E-12 1.266E-11 4.610E-11 17 104
26 M17406 Cytokine Network MSigDB C2 BIOCARTA (v6.0) 7.178E-14 1.794E-12 1.266E-11 4.665E-11 10 21
27 1458885 Th1 and Th2 cell differentiation BioSystems: KEGG 1.451E-13 3.493E-12 2.464E-11 9.431E-11 16 92
28 M16519 HIV Induced T Cell Apoptosis MSigDB C2 BIOCARTA (v6.0) 2.067E-13 4.798E-12 3.385E-11 1.343E-10 8 11
29 M19422 IL 17 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 3.847E-13 8.622E-12 6.082E-11 2.500E-10 9 17
30 1270260 Integrin cell surface interactions BioSystems: REACTOME 4.436E-13 9.610E-12 6.780E-11 2.883E-10 14 68
31 147809 Chagas disease (American trypanosomiasis) BioSystems: KEGG 7.731E-13 1.621E-11 1.144E-10 5.025E-10 16 102
32 1469482 Th17 cell differentiation BioSystems: KEGG 1.663E-12 3.378E-11 2.383E-10 1.081E-9 16 107
33 138000 IL23-mediated signaling events BioSystems: Pathway Interaction Database 1.922E-12 3.675E-11 2.593E-10 1.250E-9 11 37
34 83125 Primary immunodeficiency BioSystems: KEGG 1.922E-12 3.675E-11 2.593E-10 1.250E-9 11 37
35 83123 Allograft rejection BioSystems: KEGG 2.673E-12 4.964E-11 3.502E-10 1.737E-9 11 38
36 138018 Downstream signaling in naive CD8+ T cells BioSystems: Pathway Interaction Database 3.109E-12 5.613E-11 3.960E-10 2.021E-9 12 50
37 M6910 Cytokines and Inflammatory Response MSigDB C2 BIOCARTA (v6.0) 3.699E-12 6.499E-11 4.585E-10 2.404E-9 10 29
38 M1467 The Co-Stimulatory Signal During T-cell Activation MSigDB C2 BIOCARTA (v6.0) 4.431E-12 7.580E-11 5.348E-10 2.880E-9 9 21
39 1269177 Costimulation by the CD28 family BioSystems: REACTOME 2.215E-11 3.691E-10 2.604E-9 1.440E-8 13 73
40 128760 Intestinal immune network for IgA production BioSystems: KEGG 5.662E-11 9.201E-10 6.491E-9 3.680E-8 11 49
41 PW:0000286 integrin signaling Pathway Ontology 7.828E-11 1.241E-9 8.756E-9 5.088E-8 10 38
42 99051 Chemokine signaling pathway BioSystems: KEGG 8.154E-11 1.262E-9 8.903E-9 5.300E-8 18 182
43 M10765 Lck and Fyn tyrosine kinases in initiation of TCR Activation MSigDB C2 BIOCARTA (v6.0) 1.537E-10 2.323E-9 1.639E-8 9.989E-8 7 13
44 83080 T cell receptor signaling pathway BioSystems: KEGG 1.618E-10 2.390E-9 1.686E-8 1.051E-7 14 103
45 M18215 Role of Tob in T-cell activation MSigDB C2 BIOCARTA (v6.0) 2.261E-10 3.265E-9 2.304E-8 1.469E-7 8 21
46 200309 Rheumatoid arthritis BioSystems: KEGG 3.430E-10 4.847E-9 3.420E-8 2.230E-7 13 90
47 213780 Tuberculosis BioSystems: KEGG 5.305E-10 7.337E-9 5.176E-8 3.448E-7 17 179
48 M1462 CTL mediated immune response against target cells MSigDB C2 BIOCARTA (v6.0) 5.628E-10 7.618E-9 5.375E-8 3.658E-7 7 15
49 1383036 Interleukin-19, 20, 22, 24 BioSystems: REACTOME 5.743E-10 7.618E-9 5.375E-8 3.733E-7 6 9
50 138055 TCR signaling in naive CD8+ T cells BioSystems: Pathway Interaction Database 9.595E-10 1.247E-8 8.800E-8 6.237E-7 10 48
Show 45 more annotations

8: Pubmed [Display Chart] 186 input genes in category / 67273 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17703412 Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes. Pubmed 2.463E-89 1.657E-84 1.937E-83 1.657E-84 59 207
2 20503287 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Pubmed 1.081E-87 3.368E-83 3.939E-82 7.270E-83 58 204
3 19258923 Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Pubmed 1.502E-87 3.368E-83 3.939E-82 1.010E-82 58 205
4 1431091 Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells. Pubmed 4.156E-60 6.989E-56 8.173E-55 2.796E-55 31 50
5 20568250 Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. Pubmed 1.133E-48 1.524E-44 1.783E-43 7.622E-44 31 95
6 19573080 Common genetic variants in candidate genes and risk of familial lymphoid malignancies. Pubmed 2.368E-40 2.655E-36 3.105E-35 1.593E-35 30 145
7 19773279 Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. Pubmed 1.005E-36 9.655E-33 1.129E-31 6.758E-32 33 263
8 23128233 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. Pubmed 2.602E-34 2.188E-30 2.559E-29 1.751E-29 34 342
9 20331378 Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus. Pubmed 8.104E-33 6.057E-29 7.083E-28 5.452E-28 24 112
10 18633131 Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. Pubmed 9.413E-31 6.332E-27 7.405E-26 6.332E-26 18 44
11 20673868 A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM). Pubmed 2.555E-30 1.563E-26 1.827E-25 1.719E-25 26 186
12 20452482 Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Pubmed 2.956E-30 1.657E-26 1.938E-25 1.988E-25 26 187
13 24162774 The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression. Pubmed 1.275E-28 6.598E-25 7.715E-24 8.577E-24 22 119
14 25275127 HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins. Pubmed 2.938E-27 1.412E-23 1.651E-22 1.977E-22 16 40
15 15340161 Signal peptide prediction based on analysis of experimentally verified cleavage sites. Pubmed 2.935E-26 1.316E-22 1.539E-21 1.974E-21 26 264
16 21460847 The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Pubmed 4.256E-26 1.790E-22 2.093E-21 2.863E-21 13 20
17 19247692 Analyses of associations with asthma in four asthma population samples from Canada and Australia. Pubmed 7.569E-26 2.995E-22 3.503E-21 5.092E-21 19 92
18 20485444 Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population. Pubmed 1.539E-25 5.753E-22 6.727E-21 1.035E-20 20 115
19 20716621 Genetic polymorphisms in adaptive immunity genes and childhood acute lymphoblastic leukemia. Pubmed 1.866E-25 6.605E-22 7.724E-21 1.255E-20 14 29
20 12648490 Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs. Pubmed 6.202E-25 2.086E-21 2.440E-20 4.173E-20 13 23
21 20438785 Polymorphisms in innate immunity genes and risk of childhood leukemia. Pubmed 1.337E-24 4.282E-21 5.007E-20 8.992E-20 23 206
22 20406964 Risk of meningioma and common variation in genes related to innate immunity. Pubmed 1.498E-24 4.579E-21 5.355E-20 1.007E-19 23 207
23 19423540 Common variation in genes related to innate immunity and risk of adult glioma. Pubmed 1.677E-24 4.904E-21 5.735E-20 1.128E-19 23 208
24 21061265 Hodgkin disease risk: role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes. Pubmed 2.246E-24 6.296E-21 7.362E-20 1.511E-19 12 18
25 19008373 Increased Foxp3(+) CD4(+) regulatory T cells with intact suppressive activity but altered cellular localization in murine lupus. Pubmed 6.071E-24 1.634E-20 1.910E-19 4.084E-19 12 19
26 17152005 Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Pubmed 9.731E-24 2.518E-20 2.944E-19 6.546E-19 11 14
27 19170196 Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. Pubmed 2.416E-23 6.019E-20 7.039E-19 1.625E-18 27 383
28 19527514 Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants. Pubmed 6.252E-23 1.450E-19 1.696E-18 4.206E-18 19 128
29 18818748 Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants. Pubmed 6.252E-23 1.450E-19 1.696E-18 4.206E-18 19 128
30 23383108 Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. Pubmed 9.743E-23 2.185E-19 2.555E-18 6.554E-18 18 108
31 19625176 PTEN identified as important risk factor of chronic obstructive pulmonary disease. Pubmed 2.701E-22 5.861E-19 6.853E-18 1.817E-17 26 376
32 19773451 Role of inflammation gene polymorphisms on pain severity in lung cancer patients. Pubmed 2.979E-22 6.263E-19 7.324E-18 2.004E-17 13 33
33 19692168 Genetic susceptibility to distinct bladder cancer subphenotypes. Pubmed 3.090E-22 6.299E-19 7.366E-18 2.079E-17 27 422
34 18676680 Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. Pubmed 3.775E-22 7.389E-19 8.640E-18 2.540E-17 26 381
35 9208839 A spontaneously arising mutation in the DLAARN motif of murine ZAP-70 abrogates kinase activity and arrests thymocyte development. Pubmed 3.844E-22 7.389E-19 8.640E-18 2.586E-17 10 12
36 19275586 HIV-1 mediated immune pathogenesis: spotlight on the role of viral protein R (Vpr). Pubmed 6.109E-22 1.142E-18 1.335E-17 4.109E-17 12 25
37 20811626 Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Pubmed 1.186E-21 2.156E-18 2.521E-17 7.978E-17 13 36
38 19019335 Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants. Pubmed 1.562E-21 2.766E-18 3.234E-17 1.051E-16 18 125
39 15240714 CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. Pubmed 1.659E-21 2.790E-18 3.262E-17 1.116E-16 10 13
40 12147624 MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses. Pubmed 1.659E-21 2.790E-18 3.262E-17 1.116E-16 10 13
41 19264973 Assessing the reproducibility of asthma candidate gene associations, using genome-wide data. Pubmed 2.756E-21 4.522E-18 5.287E-17 1.854E-16 13 38
42 20012528 Implications of Nef: host cell interactions in viral persistence and progression to AIDS. Pubmed 8.854E-21 1.418E-17 1.658E-16 5.957E-16 13 41
43 7539755 Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120. Pubmed 9.155E-21 1.432E-17 1.675E-16 6.159E-16 11 21
44 21048031 Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. Pubmed 1.185E-20 1.812E-17 2.119E-16 7.974E-16 21 231
45 20190752 Multiple common variants for celiac disease influencing immune gene expression. Pubmed 2.537E-20 3.792E-17 4.434E-16 1.706E-15 15 76
46 11239407 The TNF and TNF receptor superfamilies: integrating mammalian biology. Pubmed 4.030E-20 5.893E-17 6.891E-16 2.711E-15 12 33
47 16973387 Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor. Pubmed 4.586E-20 6.565E-17 7.677E-16 3.085E-15 10 16
48 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 2.265E-19 3.174E-16 3.712E-15 1.524E-14 20 229
49 17521585 Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells. Pubmed 2.718E-19 3.732E-16 4.364E-15 1.829E-14 8 8
50 19559392 A candidate gene association study of 77 polymorphisms in migraine. Pubmed 3.046E-19 4.099E-16 4.793E-15 2.049E-14 13 52
Show 45 more annotations

9: Interaction [Display Chart] 185 input genes in category / 3575 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CD9 CD9 interactions 6.789E-19 2.427E-15 2.126E-14 2.427E-15 13 29
2 int:LCK LCK interactions 2.020E-18 3.611E-15 3.163E-14 7.222E-15 21 143
3 int:PTPRC PTPRC interactions 5.859E-16 6.982E-13 6.116E-12 2.095E-12 14 57
4 int:PTPN6 PTPN6 interactions 2.266E-15 2.025E-12 1.774E-11 8.100E-12 20 176
5 int:CD82 CD82 interactions 1.370E-14 9.792E-12 8.577E-11 4.896E-11 12 43
6 int:CD53 CD53 interactions 1.420E-12 8.458E-10 7.409E-9 5.075E-9 7 10
7 int:SYK SYK interactions 1.553E-11 7.934E-9 6.949E-8 5.554E-8 15 138
8 int:FYN FYN interactions 2.196E-11 9.814E-9 8.596E-8 7.851E-8 19 254
9 int:PTPN11 PTPN11 interactions 3.342E-11 1.327E-8 1.163E-7 1.195E-7 18 229
10 int:CD247 CD247 interactions 4.508E-11 1.611E-8 1.412E-7 1.611E-7 10 47
11 int:PIK3R1 PIK3R1 interactions 1.519E-10 4.936E-8 4.323E-7 5.429E-7 18 251
12 int:CD19 CD19 interactions 2.290E-10 6.220E-8 5.448E-7 8.185E-7 8 27
13 int:CCR10 CCR10 interactions 2.436E-10 6.220E-8 5.448E-7 8.708E-7 6 10
14 int:CD38 CD38 interactions 2.436E-10 6.220E-8 5.448E-7 8.708E-7 6 10
15 int:CD80 CD80 interactions 7.025E-10 1.674E-7 1.467E-6 2.511E-6 5 6
16 int:CD28 CD28 interactions 1.248E-9 2.625E-7 2.299E-6 4.462E-6 7 21
17 int:CD2 CD2 interactions 1.248E-9 2.625E-7 2.299E-6 4.462E-6 7 21
18 int:ITGB1 ITGB1 interactions 1.390E-9 2.761E-7 2.419E-6 4.970E-6 13 133
19 int:CD4 CD4 interactions 2.110E-9 3.970E-7 3.477E-6 7.543E-6 12 112
20 int:CD5 CD5 interactions 2.586E-9 4.622E-7 4.048E-6 9.244E-6 7 23
21 int:LYN LYN interactions 2.932E-9 4.992E-7 4.372E-6 1.048E-5 16 232
22 int:IL13 IL13 interactions 6.446E-9 1.048E-6 9.175E-6 2.305E-5 5 8
23 int:ACKR1 ACKR1 interactions 2.852E-8 4.433E-6 3.883E-5 1.020E-4 5 10
24 int:CD81 CD81 interactions 3.899E-8 5.807E-6 5.087E-5 1.394E-4 15 242
25 int:CD3E CD3E interactions 4.125E-8 5.899E-6 5.167E-5 1.475E-4 7 33
26 int:IL10 IL10 interactions 5.726E-8 7.874E-6 6.897E-5 2.047E-4 4 5
27 int:IL2RG IL2RG interactions 7.850E-8 1.039E-5 9.104E-5 2.806E-4 7 36
28 int:ACKR4 ACKR4 interactions 8.812E-8 1.086E-5 9.515E-5 3.150E-4 5 12
29 int:IL12A IL12A interactions 8.812E-8 1.086E-5 9.515E-5 3.150E-4 5 12
30 int:LGALS1 LGALS1 interactions 2.122E-7 2.529E-5 2.215E-4 7.587E-4 10 109
31 int:CD63 CD63 interactions 2.962E-7 3.416E-5 2.992E-4 1.059E-3 6 27
32 int:CCL19 CCL19 interactions 3.943E-7 4.405E-5 3.859E-4 1.410E-3 4 7
33 int:CD3D CD3D interactions 4.697E-7 4.939E-5 4.326E-4 1.679E-3 5 16
34 int:CD46 CD46 interactions 4.697E-7 4.939E-5 4.326E-4 1.679E-3 5 16
35 int:INPP5D INPP5D interactions 7.415E-7 7.558E-5 6.620E-4 2.651E-3 8 71
36 int:IL10RB IL10RB interactions 7.822E-7 7.558E-5 6.620E-4 2.796E-3 4 8
37 int:CD86 CD86 interactions 7.822E-7 7.558E-5 6.620E-4 2.796E-3 4 8
38 int:TLR1 TLR1 interactions 9.059E-7 8.523E-5 7.465E-4 3.239E-3 5 18
39 int:ITGA6 ITGA6 interactions 1.093E-6 1.002E-4 8.773E-4 3.906E-3 7 52
40 int:ZAP70 ZAP70 interactions 1.135E-6 1.014E-4 8.883E-4 4.057E-3 8 75
41 int:PTGFRN PTGFRN interactions 1.219E-6 1.063E-4 9.310E-4 4.358E-3 5 19
42 int:MYD88 MYD88 interactions 1.865E-6 1.587E-4 1.390E-3 6.667E-3 8 80
43 int:FCGR3A FCGR3A interactions 2.097E-6 1.744E-4 1.527E-3 7.498E-3 5 21
44 int:TRAF3 TRAF3 interactions 2.304E-6 1.834E-4 1.606E-3 8.238E-3 10 141
45 int:CXCL13 CXCL13 interactions 2.308E-6 1.834E-4 1.606E-3 8.252E-3 4 10
46 int:VAV1 VAV1 interactions 2.665E-6 2.072E-4 1.814E-3 9.529E-3 9 112
47 int:H3F3B H3F3B interactions 3.236E-6 2.462E-4 2.156E-3 1.157E-2 8 86
48 int:DPP4 DPP4 interactions 3.410E-6 2.540E-4 2.225E-3 1.219E-2 5 23
49 int:TSPAN4 TSPAN4 interactions 3.598E-6 2.572E-4 2.253E-3 1.286E-2 4 11
50 int:IL2RA IL2RA interactions 3.598E-6 2.572E-4 2.253E-3 1.286E-2 4 11
Show 45 more annotations

10: Cytoband [Display Chart] 186 input genes in category / 130 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13.4 19q13.4 2.612E-7 3.396E-5 1.850E-4 3.396E-5 7 80
2 17q11.2-q12 17q11.2-q12 5.238E-6 3.405E-4 1.855E-3 6.810E-4 3 7
3 11q23 11q23 4.135E-5 1.792E-3 9.762E-3 5.375E-3 4 36
4 1q32 1q32 1.408E-4 3.498E-3 1.906E-2 1.831E-2 4 49
5 4q26-q27 4q26-q27 1.706E-4 3.498E-3 1.906E-2 2.218E-2 2 4
6 1q31-q32 1q31-q32 1.706E-4 3.498E-3 1.906E-2 2.218E-2 2 4
7 4q21 4q21 1.883E-4 3.498E-3 1.906E-2 2.448E-2 3 21
8 12p13 12p13 4.463E-4 7.252E-3 3.951E-2
5.802E-2
 4 66
9 1p13.1 1p13.1 7.368E-4 1.064E-2
5.799E-2
9.579E-2
 3 33
10 2q12 2q12 1.825E-3 2.372E-2
1.292E-1
2.372E-1
 2 12
11 1p36.3 1p36.3 2.498E-3 2.952E-2
1.609E-1
3.248E-1
 2 14
12 1p36 1p36 2.770E-3 3.001E-2
1.635E-1
3.601E-1
 3 52
13 16p11.2 16p11.2 4.905E-3 4.360E-2
2.376E-1
6.377E-1
 5 203
14 2q32.2-q32.3 2q32.2-q32.3 5.366E-3 4.360E-2
2.376E-1
6.976E-1
 1 1
15 Xq13.1-q28 Xq13.1-q28 5.366E-3 4.360E-2
2.376E-1
6.976E-1
 1 1
16 1q21.3-q22 1q21.3-q22 5.366E-3 4.360E-2
2.376E-1
6.976E-1
 1 1
17 Xp22.3 Xp22.3 6.729E-3 4.798E-2
2.614E-1
8.747E-1
 2 23
18 19p13 19p13 9.878E-3 4.798E-2
2.614E-1
1.000E0
 2 28
19 2q33 2q33 1.057E-2 4.798E-2
2.614E-1
1.000E0
 2 29
20 6q23.3 6q23.3 1.057E-2 4.798E-2
2.614E-1
1.000E0
 2 29
21 20p13-p12.2 20p13-p12.2 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
22 3q13.3-q21 3q13.3-q21 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
23 17q25.2-q25.3 17q25.2-q25.3 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
24 1p35-p34.3 1p35-p34.3 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
25 4q13-q21 4q13-q21 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
26 16p12.1-p11.2 16p12.1-p11.2 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
27 11q13.1-q13.3 11q13.1-q13.3 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
28 12q11-q13 12q11-q13 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
29 17q12-q21.2 17q12-q21.2 1.070E-2 4.798E-2
2.614E-1
1.000E0
 1 2
30 12p13.3 12p13.3 1.129E-2 4.892E-2
2.665E-1
1.000E0
 2 30
Show 25 more annotations

11: Transcription Factor Binding Site [Display Chart] 131 input genes in category / 402 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$NFKB Q6 01 V$NFKB Q6 01 2.651E-8 1.066E-5 7.007E-5 1.066E-5 15 187
2 V$NFKAPPAB 01 V$NFKAPPAB 01 4.738E-6 7.801E-4 5.129E-3 1.905E-3 13 211
3 V$CREL 01 V$CREL 01 5.822E-6 7.801E-4 5.129E-3 2.340E-3 13 215
4 V$PEA3 Q6 V$PEA3 Q6 9.188E-6 9.234E-4 6.071E-3 3.693E-3 12 191
5 V$NFKB C V$NFKB C 4.709E-5 3.786E-3 2.489E-2 1.893E-2 12 225
6 V$NFKAPPAB65 01 V$NFKAPPAB65 01 6.231E-5 4.175E-3 2.745E-2 2.505E-2 11 196
7 TTCYNRGAA V$STAT5B 01 TTCYNRGAA V$STAT5B 01 2.309E-4 1.326E-2
8.719E-2
9.283E-2
 12 266
8 GGGNNTTTCC V$NFKB Q6 01 GGGNNTTTCC V$NFKB Q6 01 6.018E-4 3.024E-2
1.988E-1
2.419E-1
 7 108
Show 3 more annotations

12: Gene Family [Display Chart] 180 input genes in category / 59 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 471 CD molecules|Tumor necrosis factor superfamily genenames.org 1.342E-152 7.916E-151 3.691E-150 7.916E-151 116 394
2 601 Interleukins|PDZ domain containing genenames.org 1.300E-23 3.834E-22 1.788E-21 7.668E-22 17 43
3 594 Immunoglobulin like domain containing|Interleukin receptors|TIR domain containing genenames.org 1.003E-19 1.972E-18 9.196E-18 5.916E-18 24 193
4 590 Receptor Tyrosine Kinases|CD molecules|V-set domain containing|I-set domain containing|Immunoglobulin like domain containing genenames.org 2.698E-15 3.980E-14 1.856E-13 1.592E-13 19 163
5 948 CD molecules|Toll like receptors genenames.org 3.474E-15 4.099E-14 1.911E-13 2.049E-13 8 10
6 483 Chemokine ligands|Endogenous ligands genenames.org 1.315E-14 1.293E-13 6.031E-13 7.760E-13 12 45
7 1160 CD molecules|Complement system|Integrin alpha subunits genenames.org 3.344E-14 2.819E-13 1.314E-12 1.973E-12 9 18
8 602 Fibronectin type III domain containing|Interleukin receptors genenames.org 7.819E-12 5.766E-11 2.689E-10 4.613E-10 10 42
9 542 Endogenous ligands genenames.org 2.403E-11 1.576E-10 7.347E-10 1.418E-9 18 237
10 768 Tetraspanins genenames.org 8.827E-10 5.208E-9 2.429E-8 5.208E-8 8 33
11 782 Tumor necrosis factor receptor superfamily genenames.org 1.072E-8 5.750E-8 2.681E-7 6.325E-7 7 29
12 592 Butyrophilins|V-set domain containing|C2-set domain containing genenames.org 1.168E-7 5.744E-7 2.678E-6 6.893E-6 7 40
13 781 CD molecules|Tumor necrosis factor superfamily genenames.org 6.920E-7 2.916E-6 1.360E-5 4.083E-5 5 18
14 910 FKBP prolyl isomerases genenames.org 6.920E-7 2.916E-6 1.360E-5 4.083E-5 5 18
15 1182 CD molecules|Inhibitory leukocyte immunoglobulin like receptors genenames.org 9.386E-6 3.692E-5 1.722E-4 5.538E-4 3 5
16 1298 C-type lectin domain containing genenames.org 5.034E-5 1.856E-4 8.656E-4 2.970E-3 5 41
17 1091 C-C motif chemokine receptors genenames.org 1.086E-4 3.769E-4 1.757E-3 6.407E-3 3 10
18 1253 Scavenger receptors genenames.org 1.361E-4 4.461E-4 2.080E-3 8.030E-3 4 27
19 492 Complement system|Sushi domain containing genenames.org 4.262E-4 1.323E-3 6.171E-3 2.514E-2 4 36
20 958 Membrane spanning 4-domains genenames.org 6.966E-4 2.055E-3 9.582E-3 4.110E-2 3 18
21 494 C-type lectin domain family genenames.org 1.186E-3 3.332E-3 1.554E-2
6.996E-2
 4 47
22 1094 CD molecules|C-X-C motif chemokine receptors genenames.org 1.422E-3 3.815E-3 1.779E-2
8.392E-2
 2 6
23 321 Receptor Tyrosine Kinases|Protein phosphatase 1 regulatory subunits genenames.org 7.192E-3 1.845E-2
8.604E-2
4.243E-1
 3 40
24 1093 C-X-3-C motif chemokine receptors genenames.org 9.893E-3 2.335E-2
1.089E-1
5.837E-1
 1 1
25 991 Histone deacetylases, class IV genenames.org 9.893E-3 2.335E-2
1.089E-1
5.837E-1
 1 1
26 620 Killer cell immunoglobulin like receptors genenames.org 1.342E-2 3.045E-2
1.420E-1
7.918E-1
 2 18
27 555 Receptor Tyrosine Kinases|Fibronectin type III domain containing|V-set domain containing|Immunoglobulin like domain containing genenames.org 2.155E-2 4.709E-2
2.196E-1
1.000E0
 5 160
Show 22 more annotations

13: Coexpression [Display Chart] 186 input genes in category / 8203 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17174972-TableS1 Human Zola07 426genes CellDifferentiationMarkers GeneSigDB 8.076E-155 6.625E-151 6.353E-150 6.625E-151 109 345
2 M5950 Genes up-regulated during transplant rejection. MSigDB H: Hallmark Gene Sets (v6.0) 3.867E-56 1.586E-52 1.521E-51 3.172E-52 47 200
3 19795415-Table1 Mouse Lung Beisiegel09 262genes GeneSigDB 2.723E-39 7.445E-36 7.139E-35 2.233E-35 37 207
4 20220088-SuppTable2a Human Immune Allen10 106genes GeneSigDB 2.110E-35 4.327E-32 4.149E-31 1.731E-31 28 103
5 M5932 Genes defining inflammatory response. MSigDB H: Hallmark Gene Sets (v6.0) 2.218E-32 3.639E-29 3.490E-28 1.820E-28 32 200
6 M8513 Genes up-regulated in the normal-like subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.364E-30 3.232E-27 3.100E-26 1.939E-26 41 476
7 M1851 Up-regulated genes that best disciminate plasmablastic plasmacytoma from plasmacytic plasmacytoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.127E-30 6.008E-27 5.761E-26 4.206E-26 33 259
8 20460173-ImmPortAntimicrobials Human Immune Kong10 544genes ImmPort Antimicrobials GeneSigDB 1.935E-29 1.984E-26 1.903E-25 1.587E-25 40 469
9 M1985 Inflammatory cytokines and their receptors modulated in brain tumors after treatment with an oncocytic virus, a potential anticancer therapy. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.294E-29 6.648E-26 6.375E-25 5.984E-25 19 44
10 19014521-TableS6b Human Breast Reyal08 159genes GeneSigDB 1.555E-28 1.276E-25 1.223E-24 1.276E-24 27 154
11 M5897 Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. MSigDB H: Hallmark Gene Sets (v6.0) 3.325E-27 2.479E-24 2.378E-23 2.727E-23 22 87
12 M11428 Inflammatory cytokines, chemokines and their cognate receptors up-regulated in THP-1 cells (monocyte) after treatment with PSMD4 [GeneID=5710]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.327E-25 9.072E-23 8.699E-22 1.089E-21 20 73
13 19383967-Table1 Mouse StemCell Pucci09 80genes GeneSigDB 2.446E-25 1.543E-22 1.480E-21 2.006E-21 20 75
14 20460173-ImmPortCytokines Human Immune Kong10 456genes ImmPort Cytokines GeneSigDB 5.607E-25 3.285E-22 3.150E-21 4.599E-21 35 433
15 16014681-table2 Human StemCell Bohgaki05 118genes GeneSigDB 3.331E-24 1.821E-21 1.747E-20 2.732E-20 22 116
16 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 4.833E-24 2.478E-21 2.376E-20 3.965E-20 30 303
17 M5369 Genes up-regulated in atypical ductal hyperplastic tissues from patients with (ADHC) breast cancer vs those without the cancer (ADH). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.632E-23 7.876E-21 7.553E-20 1.339E-19 29 287
18 20460173-ImmPortInterleukins Human Immune Kong10 47genes ImmPort Interleukins GeneSigDB 2.189E-23 9.976E-21 9.566E-20 1.796E-19 16 42
19 16423051-Table1 Human Leukemia Larsson06 44genes GeneSigDB 3.462E-23 1.495E-20 1.433E-19 2.840E-19 16 43
20 M6474 Genes down-regulated in NKT cells versus CD8A [GeneID=925] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.110E-22 4.554E-20 4.367E-19 9.108E-19 25 200
21 19797726-SuppTable5 Human Lymphoma VanLoo09 25genes GeneSigDB 3.039E-22 1.187E-19 1.138E-18 2.493E-18 12 17
22 16479545-Table2 Mouse Lung not cancer Kahnert06 70genes GeneSigDB 6.123E-22 2.283E-19 2.189E-18 5.023E-18 16 50
23 M10319 Genes up-regulated in prostate cancer samples from African-American patients compared to those from the European-American patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.384E-22 2.634E-19 2.526E-18 6.057E-18 28 298
24 M6808 Genes down-regulated in B lymphocytes treated by anti-HEL and expressing BCR [GeneID=613] fusions with: IgM versus IgMG. MSigDB C7: Immunologic Signatures (v6.0) 9.671E-22 3.305E-19 3.170E-18 7.933E-18 23 170
25 M1869 Genes up-regulated in bone marrow progenitors by constitutively active NOTCH1 [GeneID=4851]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.271E-21 4.170E-19 3.999E-18 1.043E-17 16 52
26 M10454 Genes up-regulated in pulpal tissue extracted from carious teeth. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.406E-21 7.414E-19 7.110E-18 1.974E-17 26 253
27 11298554-Table1 Human Lymphoma Murakami02 22genes GeneSigDB 2.440E-21 7.414E-19 7.110E-18 2.002E-17 12 19
28 20220088-SuppTable2b Human Immune Allen10 42genes GeneSigDB 1.908E-19 5.589E-17 5.360E-16 1.565E-15 13 33
29 M6905 Genes down-regulated in CD133+ [GeneID=8842] cells (hematopoietic stem cells, HSC) compared to the CD133- cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.880E-19 1.946E-16 1.866E-15 5.644E-15 23 226
30 M5947 Genes up-regulated by STAT5 in response to IL2 stimulation. MSigDB H: Hallmark Gene Sets (v6.0) 7.603E-19 2.079E-16 1.994E-15 6.237E-15 22 200
31 18245496-SuppTable2 Human Prostate Wallace08 489genes GeneSigDB 1.171E-18 3.100E-16 2.973E-15 9.609E-15 28 392
32 16081686-SuppTable2 Human Lymphoma Tome05 357genes GeneSigDB 1.285E-18 3.294E-16 3.159E-15 1.054E-14 20 155
33 15642130-TableS1 Rat Immune Rioja04 438genes GeneSigDB 1.348E-18 3.352E-16 3.214E-15 1.106E-14 26 325
34 19797726-Table2b Human Lymphoma VanLoo09 40genes GeneSigDB 2.593E-18 6.255E-16 5.999E-15 2.127E-14 13 39
35 18922855-Table1 Human StemCell Kuttruff08 108genes GeneSigDB 3.620E-18 8.484E-16 8.136E-15 2.969E-14 17 99
36 11573962-Table4 Human Viral Sun01 27genes Cytokine-Related GeneSigDB 4.391E-18 1.001E-15 9.595E-15 3.602E-14 11 22
37 M1978 Genes down-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.547E-18 1.230E-15 1.179E-14 4.550E-14 13 41
38 17638852-Table2 Human Lymphoma Shin07 62genes GeneSigDB 7.031E-18 1.518E-15 1.455E-14 5.767E-14 14 54
39 12393520-Table1 Human Bone Marrow Zhan03 23genes GeneSigDB 8.358E-18 1.758E-15 1.686E-14 6.856E-14 11 23
40 16109776-TableS1 Human Leukemia Verhaak05 568genes GeneSigDB 1.103E-17 2.262E-15 2.170E-14 9.050E-14 28 427
41 16140871-SuppTable7 Human Leukemia Toren05 224genes GeneSigDB 2.590E-17 5.182E-15 4.970E-14 2.125E-13 19 155
42 12972399-Table1 Mouse Lung not cancer Vuillemenot04 64genes GeneSigDB 1.851E-16 3.616E-14 3.467E-13 1.519E-12 13 52
43 M3673 Genes up-regulated in comparison of regulatory T cell (Treg) from mice infected with S. mansoni versus T effector cells from the infected mice. MSigDB C7: Immunologic Signatures (v6.0) 2.079E-16 3.966E-14 3.803E-13 1.705E-12 20 200
44 17206280-TableS1C Mouse Breast Park07 173genes GeneSigDB 4.310E-16 8.034E-14 7.705E-13 3.535E-12 17 130
45 16291580-Table2a Human Lymphoma Karube06 17genes GeneSigDB 5.541E-16 1.010E-13 9.685E-13 4.545E-12 9 15
46 16857994-TableS1 Human Leukemia Chapiro06 156genes GeneSigDB 6.880E-16 1.227E-13 1.176E-12 5.643E-12 15 91
47 20502458-TableS6a Human Sarcoma Missiaglia10 176genes GeneSigDB 1.028E-15 1.794E-13 1.720E-12 8.431E-12 16 114
48 19383967-Table2 Mouse StemCell Pucci09 39genes GeneSigDB 1.638E-15 2.800E-13 2.685E-12 1.344E-11 11 34
49 15504237-Table1 Mouse StemCell Hutton04 134genes GeneSigDB 2.555E-15 4.278E-13 4.102E-12 2.096E-11 15 99
50 M2933 Genes up-regulated in skin after injection of Trypanosoma cruzi (strain Y): wildtype (BALB/c) versus IFNAR1 [GeneID=3454] knockout. MSigDB C7: Immunologic Signatures (v6.0) 3.145E-15 5.160E-13 4.948E-12 2.580E-11 19 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 184 input genes in category / 5571 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 lymph node lymph node Human Protein Atlas 3.875E-58 2.159E-54 1.987E-53 2.159E-54 53 268
2 appendix appendix Human Protein Atlas 5.968E-40 1.662E-36 1.530E-35 3.325E-36 37 191
3 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/7 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/7 TCGA-Breast 6.187E-35 1.149E-31 1.057E-30 3.447E-31 31 145
4 GSM538365 500 alpha beta T cells, T.4Mem.Sp, 4+ 8- 25- 44hi 122lo, Spleen, avg-3 Immgen.org, GSE15907 4.716E-34 6.569E-31 6.045E-30 2.627E-30 40 343
5 GSM854324 500 Myeloid Cells, MF.Sbcaps.SLN, CD11b+ CD169+ F4/80-, Lymph Node, avg-2 Immgen.org, GSE15907 5.958E-34 6.639E-31 6.109E-30 3.319E-30 40 345
6 GSM538371 500 alpha beta T cells, T.4Mem44h62l.Sp, CD4 TCRb CD44hi CD62Llo, Spleen, avg-3 Immgen.org, GSE15907 5.408E-32 5.021E-29 4.621E-28 3.013E-28 39 359
7 spleen spleen Human Protein Atlas 1.326E-31 1.055E-28 9.709E-28 7.385E-28 37 315
8 GSM476681 500 gamma delta T cells, Tgd.vg2-.act.Sp, TCRd+ Vg2- CD44+, Spleen, avg-3 Immgen.org, GSE15907 6.055E-30 4.216E-27 3.880E-26 3.373E-26 38 377
9 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Tubular/4/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Tubular/4/3 TCGA-Stomach 2.547E-29 1.576E-26 1.451E-25 1.419E-25 28 156
10 GSM476672 500 gamma delta T cells, Tgd.Sp, TCRd+ CD3e+, Spleen, avg-3 Immgen.org, GSE15907 2.865E-29 1.596E-26 1.469E-25 1.596E-25 38 393
11 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/5 Sample Type by Project: Shred 1/TCGA-Pancreas/Pancreatic Adenocarcinoma/Ductal Adenocarcinoma/5 TCGA-Pancreas 5.465E-29 2.768E-26 2.547E-25 3.044E-25 29 179
12 GSM538288 500 NK cells, NK.49CI-.Sp, NK1.1+ CD3- Ly49C/I-, Spleen, avg-3 Immgen.org, GSE15907 6.047E-29 2.807E-26 2.583E-25 3.369E-25 37 372
13 GSM538368 500 alpha beta T cells, T.4Mem44h62l.LN, CD4 TCRb CD44hi CD62Llo, Lymph Node, avg-3 Immgen.org, GSE15907 7.354E-29 3.152E-26 2.900E-25 4.097E-25 36 346
14 tonsil tonsil Human Protein Atlas 9.038E-29 3.596E-26 3.310E-25 5.035E-25 29 182
15 GSM538318 500 alpha beta T cells, NKT.4+.Lv, CD45 TCRb aGalCer-loaded CD1d tet CD4, Liver, avg-4 Immgen.org, GSE15907 1.226E-28 4.552E-26 4.189E-25 6.828E-25 36 351
16 GSM538322 500 alpha beta T cells, NKT.4+.Sp, TCRb aGalCer-loaded CD1d tetramer CD4, Spleen, avg-1 Immgen.org, GSE15907 1.350E-27 4.700E-25 4.325E-24 7.519E-24 35 347
17 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma /Diffuse Malignant/3 Sample Type by Project: Shred 1/TCGA-Mesothelium/Mesothelioma /Diffuse Malignant/3 TCGA-Mesothelium 4.714E-27 1.545E-24 1.422E-23 2.626E-23 25 130
18 GSM854276 500 Myeloid Cells, DC.11cloSer.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-lo CD11b+, Small Intestine, avg-4 Immgen.org, GSE15907 6.992E-27 2.164E-24 1.992E-23 3.895E-23 35 364
19 GSM854258 500 Myeloid Cells, DC.103-11b+.Salm3.SI, CD45+ MHCII+ Gr1- CD11c-hi CD11b+ CD103- F480+, Small Intestine, avg-4 Immgen.org, GSE15907 1.017E-26 2.981E-24 2.744E-23 5.665E-23 35 368
20 GSM538362 500 alpha beta T cells, T.4Mem.LN, TCRb CD44high CD122lo CD4, Lymph Node, avg-3 Immgen.org, GSE15907 2.369E-26 6.598E-24 6.072E-23 1.320E-22 34 348
21 GSM538325 500 alpha beta T cells, NKT.4-.Lv, CD45 TCRb aGalCer-loaded CD1d tet, Liver, avg-4 Immgen.org, GSE15907 3.154E-26 8.366E-24 7.699E-23 1.757E-22 34 351
22 GSM605817 500 NK cells, NK.49H-.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 3.762E-26 9.526E-24 8.767E-23 2.096E-22 36 413
23 GSM854315 500 Myeloid Cells, MF.169+11chi.SLN, CD11b+ CD169+ CD11chigh, Lymph Node, avg-2 Immgen.org, GSE15907 4.751E-26 1.151E-23 1.059E-22 2.647E-22 35 385
24 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/T cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Fat/T cell Tabula Muris Consortium 5.820E-26 1.351E-23 1.243E-22 3.242E-22 27 182
25 GSM538329 500 alpha beta T cells, NKT.4-.Sp, TCRbeta+ aGalCer tet+ CD4-, Spleen, avg-3 Immgen.org, GSE15907 7.903E-26 1.723E-23 1.585E-22 4.403E-22 33 332
26 GSM854322 500 Myeloid Cells, MF.Medl.SLN, CD11b+ CD169+ F4/80+, Lymph Node, avg-2 Immgen.org, GSE15907 8.039E-26 1.723E-23 1.585E-22 4.479E-22 35 391
27 GSM399365 500 alpha beta T cells, T.4FP3+25+.Sp, 4+ 8- GFP+ 25+, Spleen, avg-3 Immgen.org, GSE15907 2.494E-25 5.146E-23 4.735E-22 1.389E-21 33 344
28 GSM399365 100 alpha beta T cells, T.4FP3+25+.Sp, 4+ 8- GFP+ 25+, Spleen, avg-3 Immgen.org, GSE15907 3.326E-25 6.618E-23 6.091E-22 1.853E-21 20 73
29 GSM605761 500 alpha beta T cells, T.4.Sp.B16, 4+ 8- TCR+ 45+, B16 Melanoma Spleen, avg-2 Immgen.org, GSE15907 4.689E-25 8.878E-23 8.171E-22 2.612E-21 32 322
30 GSM854262 500 Myeloid Cells, DC.103-11b+.SI, CD45+ MHCII+ CD11c-hi CD11b+ CD103- F4/80+, Small Intestine, avg-7 Immgen.org, GSE15907 4.781E-25 8.878E-23 8.171E-22 2.664E-21 34 381
31 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype T cells 1 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype T cells 1 Top 200 Genes 1.563E-24 2.721E-22 2.504E-21 8.707E-21 27 205
32 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype T cells 1 PND07-28 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Subtype T cells 1 PND07-28 Top 200 Genes 1.563E-24 2.721E-22 2.504E-21 8.707E-21 27 205
33 GSM854280 500 Myeloid Cells, DC.11cloSer.SI, CD45+ MHCII+ CD11c-lo CD11b+, Small Intestine, avg-5 Immgen.org, GSE15907 4.720E-24 7.968E-22 7.332E-21 2.629E-20 33 377
34 GSM605761 100 alpha beta T cells, T.4.Sp.B16, 4+ 8- TCR+ 45+, B16 Melanoma Spleen, avg-2 Immgen.org, GSE15907 6.580E-24 1.078E-21 9.922E-21 3.666E-20 19 70
35 GSM538323 500 alpha beta T cells, NKT.4+.Sp, TCRb aGalCer-loaded CD1d-tetramer CD4, Spleen, avg-2 Immgen.org, GSE15907 1.994E-23 3.174E-21 2.921E-20 1.111E-19 31 333
36 GSM605773 100 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 2.868E-23 4.438E-21 4.084E-20 1.598E-19 19 75
37 GSM538389 500 alpha beta T cells, T.8Eff.Sp.OT1.d6.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 4.961E-23 7.470E-21 6.874E-20 2.764E-19 32 374
38 GSM605894 500 alpha beta T cells, T.8Eff.Sp.OT1.d15.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 5.847E-23 8.573E-21 7.889E-20 3.258E-19 32 376
39 GSM605823 500 Myeloid Cells, DC.103-11b+.PolyIC.Lu, CD45 MHCII CD11c CD103 CD11b, Lung, avg-3 Immgen.org, GSE15907 6.264E-23 8.947E-21 8.234E-20 3.489E-19 33 409
40 GSM538239 500 Myeloid Cells, DC.103-11b+.Lv, CD45+ CD11c+ MHC-II + CD11b high CD103-, Liver, avg-3 Immgen.org, GSE15907 7.306E-23 1.018E-20 9.364E-20 4.070E-19 33 411
41 GSM605901 500 alpha beta T cells, T.8Eff.Sp.OT1.d8.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 8.100E-23 1.101E-20 1.013E-19 4.512E-19 32 380
42 GSM538389 100 alpha beta T cells, T.8Eff.Sp.OT1.d6.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 8.584E-23 1.139E-20 1.048E-19 4.782E-19 19 79
43 GSM605907 500 alpha beta T cells, T.8Mem.Sp.OT1.d45.LisOva, CD8+ CD45.1+, Spleen, avg-2 Immgen.org, GSE15907 1.032E-22 1.336E-20 1.230E-19 5.747E-19 32 383
44 GSM538285 500 NK cells, NK.49CI+.Sp, NK1.1+ CD3- Ly49C/I+, Spleen, avg-3 Immgen.org, GSE15907 1.211E-22 1.533E-20 1.411E-19 6.744E-19 32 385
45 GSM538392 500 alpha beta T cells, T.8Eff.Sp.OT1.d8.VSVOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 1.419E-22 1.757E-20 1.617E-19 7.907E-19 32 387
46 GSM605773 500 alpha beta T cells, T.8.TI.B16, 4- 8+ TCR+ 45+, B16 Melanoma Tumor, avg-2 Immgen.org, GSE15907 1.908E-22 2.311E-20 2.127E-19 1.063E-18 31 359
47 GSM476678 500 gamma delta T cells, Tgd.vg2+.act.Sp, TCRd+ Vg2+ CD44+, Spleen, avg-3 Immgen.org, GSE15907 2.657E-22 3.150E-20 2.899E-19 1.480E-18 32 395
48 GSM605799 500 gamma delta T cells, Tgd.vg2-24ahi.Th.TCRbko, TCRd+ Vg2- CD24+, Thymus, avg-3 Immgen.org, GSE15907 2.871E-22 3.332E-20 3.067E-19 1.600E-18 32 396
49 GSM605891 500 alpha beta T cells, T.8Eff.Sp.OT1.d10.LisOva, CD8+ CD45.1+, Spleen, avg-3 Immgen.org, GSE15907 4.332E-22 4.925E-20 4.532E-19 2.413E-18 31 369
50 Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Overall Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Immune Immune Overall Top 200 Genes 4.824E-22 5.358E-20 4.931E-19 2.687E-18 23 158
Show 45 more annotations

15: Computational [Display Chart] 154 input genes in category / 335 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M688 MODULE 27 Genes in the cancer module 27. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.047E-47 3.507E-45 2.242E-44 3.507E-45 60 355
2 M15983 MODULE 46 Genes in the cancer module 46. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.503E-46 5.867E-44 3.751E-43 1.173E-43 61 394
3 M12401 MODULE 75 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.151E-43 2.402E-41 1.536E-40 7.207E-41 59 398
4 M5770 MODULE 63 Porins / transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.060E-15 8.879E-14 5.676E-13 3.552E-13 25 211
5 M17322 MODULE 76 Inflammatory response. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.276E-15 2.195E-13 1.403E-12 1.097E-12 17 81
6 M6482 MODULE 108 Genes in the cancer module 108. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.355E-14 4.106E-12 2.625E-11 2.464E-11 14 56
7 M19614 MODULE 292 Genes in the cancer module 292. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.083E-13 9.969E-12 6.373E-11 6.978E-11 19 137
8 M3463 MODULE 44 Thymus genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.448E-13 2.281E-11 1.458E-10 1.825E-10 27 327
9 M7015 MODULE 263 Chemotaxis (chemokines). MSigDb: C4 - CM: Cancer Modules (v6.0) 2.056E-12 7.653E-11 4.893E-10 6.888E-10 12 45
10 M1653 MODULE 223 Immune (defense) response. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.628E-11 1.550E-9 9.911E-9 1.550E-8 17 142
11 M11942 MODULE 412 Genes in the cancer module 412. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.774E-10 8.020E-9 5.127E-8 9.294E-8 7 13
12 M6286 MODULE 265 Caner module 265: IL receptors. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.873E-10 8.020E-9 5.127E-8 9.624E-8 9 29
13 M4595 MODULE 436 Genes in the cancer module 436. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.225E-10 8.311E-9 5.313E-8 1.080E-7 16 139
14 M414 MODULE 122 Adhesion molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.001E-10 9.574E-9 6.121E-8 1.340E-7 16 141
15 M786 MODULE 345 Immune response and Ag processing and presentation. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.249E-10 1.842E-8 1.178E-7 2.764E-7 15 127
16 M10197 MODULE 92 Secreted signaling molecules. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.151E-10 1.916E-8 1.225E-7 3.066E-7 16 149
17 M13121 MODULE 171 Genes in the cancer module 171. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.948E-9 5.810E-8 3.714E-7 9.876E-7 15 139
18 M8807 MODULE 208 Genes in the cancer module 208. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.263E-9 1.166E-7 7.451E-7 2.098E-6 14 125
19 M17161 MODULE 199 Genes in the cancer module 199. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.255E-8 2.213E-7 1.415E-6 4.205E-6 10 57
20 M18643 MODULE 73 Genes in the cancer module 73. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.484E-8 5.836E-7 3.731E-6 1.167E-5 7 23
21 M7383 MODULE 5 Lung genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.087E-8 6.519E-7 4.168E-6 1.369E-5 24 434
22 M19421 MODULE 85 Genes in the cancer module 85. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.544E-8 9.965E-7 6.371E-6 2.192E-5 9 51
23 M19458 MODULE 275 Genes in the cancer module 275. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.349E-8 1.216E-6 7.774E-6 2.797E-5 6 16
24 M18183 MODULE 121 Genes in the cancer module 121. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.065E-7 4.278E-6 2.735E-5 1.027E-4 11 99
25 M7360 MODULE 33 Immune / stress response genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.631E-7 4.866E-6 3.111E-5 1.217E-4 21 383
26 M13974 MODULE 259 RTK signaling. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.075E-7 5.251E-6 3.357E-5 1.365E-4 8 46
27 M14121 MODULE 165 Genes in the cancer module 165. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.479E-7 5.558E-6 3.553E-5 1.501E-4 10 82
28 M4219 MODULE 300 Programmed cell death. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.338E-7 6.386E-6 4.083E-5 1.788E-4 7 33
29 M14338 GNF2 HCK Neighborhood of HCK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.618E-6 1.869E-5 1.195E-4 5.419E-4 10 94
30 M7315 MODULE 119 Genes in the cancer module 119. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.012E-6 2.246E-5 1.436E-4 6.739E-4 12 144
31 M1169 GNF2 ZAP70 Neighborhood of ZAP70 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.684E-6 2.900E-5 1.854E-4 8.991E-4 6 27
32 M2944 MODULE 170 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.136E-6 3.283E-5 2.099E-4 1.051E-3 10 101
33 M6026 MODULE 424 Genes in the cancer module 424. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.811E-6 5.899E-5 3.771E-4 1.947E-3 5 18
34 M3301 MODULE 399 Genes in the cancer module 399. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.310E-5 1.253E-4 8.013E-4 4.387E-3 7 52
35 M8373 GNF2 CD33 Neighborhood of CD33 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.310E-5 1.253E-4 8.013E-4 4.387E-3 7 52
36 M11185 MODULE 128 Genes in the cancer module 128. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.833E-5 1.682E-4 1.075E-3 6.140E-3 9 98
37 M491 MODULE 288 Genes in the cancer module 288. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.857E-5 1.682E-4 1.075E-3 6.222E-3 6 37
38 M8286 MODULE 79 Genes in the cancer module 79. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.159E-5 1.903E-4 1.217E-3 7.231E-3 9 100
39 M7032 GNF2 CARD15 Neighborhood of CARD15 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 9.317E-5 8.003E-4 5.116E-3 3.121E-2 7 70
40 M5305 MODULE 361 B lymphoma expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.005E-4 8.419E-4 5.382E-3 3.367E-2 10 150
41 M12584 MODULE 289 Genes in the cancer module 289. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.178E-4 9.626E-4 6.154E-3 3.947E-2 9 124
42 M4337 MODULE 177 Genes in the cancer module 177. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.548E-4 1.235E-3 7.896E-3
5.187E-2
 8 101
43 M718 GNF2 CD14 Neighborhood of CD14 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.784E-4 1.390E-3 8.884E-3
5.976E-2
 5 35
44 M4396 GNF2 CASP1 Neighborhood of CASP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.973E-4 2.264E-3 1.447E-2
9.961E-2
 8 111
45 M18856 MODULE 456 B lymphoma expression clusters. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.358E-4 2.476E-3 1.583E-2
1.125E-1
 8 113
46 M245 GNF2 CD7 Neighborhood of CD7 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.399E-4 2.476E-3 1.583E-2
1.139E-1
 5 40
47 M19754 MODULE 375 GPCR signaling pathways (immune and neuro). MSigDb: C4 - CM: Cancer Modules (v6.0) 4.497E-4 3.206E-3 2.049E-2
1.507E-1
 7 90
48 M12582 GNF2 CD1D Neighborhood of CD1D MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 5.935E-4 4.142E-3 2.648E-2
1.988E-1
 5 45
49 M4843 MODULE 174 Genes in the cancer module 174. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.241E-4 4.267E-3 2.728E-2
2.091E-1
 7 95
50 M10511 MODULE 169 Immune response. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.073E-4 4.739E-3 3.029E-2
2.369E-1
 7 97
Show 45 more annotations

16: MicroRNA [Display Chart] 186 input genes in category / 1989 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-3199:mirSVR highEffct hsa-miR-3199:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.869E-10 1.167E-6 9.541E-6 1.167E-6 13 487
2 hsa-miR-614:mirSVR lowEffct hsa-miR-614:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.337E-7 1.330E-4 1.087E-3 2.660E-4 10 409
3 hsa-miR-615-5p:mirSVR highEffct hsa-miR-615-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.030E-7 1.346E-4 1.100E-3 4.038E-4 9 325
4 hsa-miR-499a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.096E-7 4.523E-4 3.696E-3 1.809E-3 5 67
5 hsa-miR-3181:mirSVR lowEffct hsa-miR-3181:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.735E-6 6.903E-4 5.641E-3 3.451E-3 8 312
6 hsa-miR-23a-3p:Functional MTI Functional MTI miRTarbase 4.287E-6 1.421E-3 1.161E-2 8.527E-3 7 249
7 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 9.860E-6 2.263E-3 1.850E-2 1.961E-2 7 283
8 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 1.009E-5 2.263E-3 1.850E-2 2.006E-2 7 284
9 hsa-miR-1225-3p:mirSVR highEffct hsa-miR-1225-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.056E-5 2.263E-3 1.850E-2 2.099E-2 7 286
10 hsa-miR-4281:mirSVR lowEffct hsa-miR-4281:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.274E-5 2.263E-3 1.850E-2 2.533E-2 8 410
11 hsa-miR-346:mirSVR highEffct hsa-miR-346:mirSVR conserved highEffect-0.5 MicroRNA.org 1.342E-5 2.263E-3 1.850E-2 2.669E-2 8 413
12 hsa-miR-146a-5p:Functional MTI Functional MTI miRTarbase 1.549E-5 2.263E-3 1.850E-2 3.080E-2 6 202
13 hsa-miR-1234:mirSVR lowEffct hsa-miR-1234:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.593E-5 2.263E-3 1.850E-2 3.168E-2 8 423
14 hsa-miR-1247:mirSVR lowEffct hsa-miR-1247:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.631E-5 2.263E-3 1.850E-2 3.243E-2 7 306
15 hsa-miR-181a*:mirSVR lowEffct hsa-miR-181a*:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.772E-5 2.263E-3 1.850E-2 3.525E-2 7 310
16 hsa-miR-27a*:mirSVR highEffct hsa-miR-27a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.821E-5 2.263E-3 1.850E-2 3.621E-2 8 431
17 hsa-miR-125b:mirSVR highEffct hsa-miR-125b:mirSVR conserved highEffect-0.5 MicroRNA.org 1.976E-5 2.312E-3 1.890E-2 3.931E-2 8 436
18 hsa-miR-499b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.250E-5 2.487E-3 2.032E-2 4.476E-2 4 63
19 hsa-miR-591:mirSVR highEffct hsa-miR-591:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.435E-5 2.489E-3 2.034E-2 4.843E-2 8 449
20 hsa-miR-296-5p:mirSVR highEffct hsa-miR-296-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.503E-5 2.489E-3 2.034E-2 4.978E-2 6 220
21 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.413E-5 3.086E-3 2.522E-2
6.789E-2
 8 471
22 hsa-miR-125a-5p:mirSVR highEffct hsa-miR-125a-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 3.413E-5 3.086E-3 2.522E-2
6.789E-2
 8 471
23 hsa-miR-219-5p:mirSVR highEffct hsa-miR-219-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 3.842E-5 3.323E-3 2.716E-2
7.642E-2
 8 479
24 hsa-miR-541:mirSVR highEffct hsa-miR-541:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.014E-5 3.327E-3 2.719E-2
7.984E-2
 8 482
25 hsa-miR-5702:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.483E-5 3.566E-3 2.915E-2
8.916E-2
 4 75
26 hsa-miR-3193:mirSVR lowEffct hsa-miR-3193:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.914E-5 6.054E-3 4.948E-2
1.574E-1
 7 393
27 hsa-miR-423-3p:mirSVR lowEffct hsa-miR-423-3p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 8.560E-5 6.246E-3
5.105E-2
1.703E-1
 7 398
28 hsa-miR-2861:mirSVR highEffct hsa-miR-2861:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.107E-5 6.246E-3
5.105E-2
1.811E-1
 7 402
29 hsa-miR-670-3p:TargetScan hsa-miR-670-3p TargetScan 9.107E-5 6.246E-3
5.105E-2
1.811E-1
 7 402
30 hsa-miR-663b:mirSVR highEffct hsa-miR-663b:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.027E-4 6.810E-3
5.566E-2
2.043E-1
 6 284
31 hsa-miR-4323:mirSVR highEffct hsa-miR-4323:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.108E-4 7.112E-3
5.812E-2
2.205E-1
 7 415
32 hsa-miR-181c-5p:Functional MTI Functional MTI miRTarbase 1.173E-4 7.290E-3
5.958E-2
2.333E-1
 6 291
33 hsa-miR-1273f:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.263E-4 7.398E-3
6.046E-2
2.512E-1
 6 295
34 hsa-miR-516a-5p:mirSVR highEffct hsa-miR-516a-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.293E-4 7.398E-3
6.046E-2
2.571E-1
 5 186
35 hsa-miR-938:mirSVR highEffct hsa-miR-938:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.302E-4 7.398E-3
6.046E-2
2.589E-1
 7 426
36 hsa-miR-203a-3p:Functional MTI Functional MTI miRTarbase 1.595E-4 8.813E-3
7.203E-2
3.173E-1
 6 308
37 hsa-miR-1915:mirSVR highEffct hsa-miR-1915:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.700E-4 9.138E-3
7.468E-2
3.381E-1
 7 445
38 hsa-miR-1914:mirSVR highEffct hsa-miR-1914:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.795E-4 9.396E-3
7.679E-2
3.570E-1
 7 449
39 hsa-miR-1538:mirSVR lowEffct hsa-miR-1538:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.191E-4 1.094E-2
8.943E-2
4.358E-1
 7 464
40 hsa-miR-4727-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.201E-4 1.094E-2
8.943E-2
4.377E-1
 3 45
41 GGATCCG,MIR-127:MSigDB GGATCCG,MIR-127:MSigDB MSigDB 2.346E-4 1.130E-2
9.239E-2
4.665E-1
 2 9
42 hsa-miR-1233:mirSVR highEffct hsa-miR-1233:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.387E-4 1.130E-2
9.239E-2
4.748E-1
 6 332
43 hsa-miR-1224-3p:mirSVR highEffct hsa-miR-1224-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.556E-4 1.182E-2
9.664E-2
5.084E-1
 7 476
44 hsa-miR-4253:mirSVR highEffct hsa-miR-4253:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.622E-4 1.185E-2
9.686E-2
5.214E-1
 7 478
45 hsa-miR-1247-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.929E-4 1.295E-2
1.058E-1
5.826E-1
 6 345
46 hsa-miR-503-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.011E-4 1.302E-2
1.064E-1
5.989E-1
 3 50
47 hsa-miR-92a-1*:mirSVR highEffct hsa-miR-92a-1*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.080E-4 1.303E-2
1.065E-1
6.126E-1
 7 491
48 hsa-miR-143-3p:Functional MTI Functional MTI miRTarbase 3.313E-4 1.363E-2
1.114E-1
6.589E-1
 5 228
49 hsa-miR-18b*:mirSVR highEffct hsa-miR-18b*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.358E-4 1.363E-2
1.114E-1
6.679E-1
 6 354
50 hsa-miR-130a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.863E-4 1.517E-2
1.240E-1
7.683E-1
 4 131
Show 45 more annotations

17: Drug [Display Chart] 186 input genes in category / 21615 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000019920 LS109 Stitch 2.307E-75 4.987E-71 5.265E-70 4.987E-71 67 338
2 CID000428410 NSC237521 Stitch 2.834E-70 3.063E-66 3.234E-65 6.125E-66 56 211
3 CID000007871 MF I Stitch 5.490E-50 3.955E-46 4.176E-45 1.187E-45 41 163
4 CID000130705 9-OH-B220 Stitch 5.614E-46 3.034E-42 3.203E-41 1.214E-41 36 127
5 CID000032744 polyinosinic-polycytidylic acid Stitch 3.379E-43 1.461E-39 1.542E-38 7.303E-39 44 291
6 CID000005292 AC1L1K12 Stitch 1.621E-42 5.839E-39 6.165E-38 3.503E-38 32 102
7 CID000008222 eicosane Stitch 5.930E-40 1.831E-36 1.933E-35 1.282E-35 31 107
8 CID004369063 AC1N9ZLR Stitch 3.482E-37 8.987E-34 9.489E-33 7.527E-33 36 212
9 CID000159603 resiquimod Stitch 4.030E-37 8.987E-34 9.489E-33 8.711E-33 30 115
10 CID000098285 tetrahydro-beta-carboline-3-carboxylic acid Stitch 4.158E-37 8.987E-34 9.489E-33 8.987E-33 31 129
11 CID000447989 (2s,5s)-5-Carboxymethylproline Stitch 3.712E-36 7.293E-33 7.701E-32 8.023E-32 40 314
12 CID000067874 p-trifluoromethylphenol Stitch 4.660E-35 8.394E-32 8.863E-31 1.007E-30 29 118
13 ctd:C433788 lipopolysaccharide, E. coli O26-B6 CTD 8.744E-34 1.454E-30 1.535E-29 1.890E-29 30 145
14 CID002826713 alpha-GalCer Stitch 1.326E-33 2.048E-30 2.162E-29 2.867E-29 29 131
15 ctd:C402696 TMC 120A CTD 2.822E-32 4.067E-29 4.294E-28 6.101E-28 24 75
16 CID000003399 CAS 80474-14-2 Stitch 5.337E-32 7.210E-29 7.613E-28 1.154E-27 28 131
17 CID006334320 francium;germanium Stitch 4.073E-31 5.179E-28 5.468E-27 8.804E-27 27 124
18 CID000057469 imiquimod Stitch 2.548E-30 3.060E-27 3.231E-26 5.508E-26 27 132
19 CID000002931 AC1L1ESQ Stitch 3.054E-30 3.474E-27 3.668E-26 6.600E-26 26 117
20 ctd:D004137 Dinitrochlorobenzene CTD 3.318E-30 3.586E-27 3.786E-26 7.172E-26 38 383
21 ctd:C007262 deoxynivalenol CTD 6.918E-30 7.120E-27 7.518E-26 1.495E-25 41 483
22 CID000027435 AC1L1D7P Stitch 1.048E-29 1.030E-26 1.087E-25 2.266E-25 25 107
23 CID000002909 cyclophorine Stitch 1.261E-29 1.185E-26 1.251E-25 2.725E-25 39 427
24 CID000034196 trinitrochlorobenzene Stitch 1.649E-29 1.485E-26 1.568E-25 3.563E-25 19 41
25 ctd:C038459 curdlan CTD 1.746E-29 1.510E-26 1.594E-25 3.774E-25 25 109
26 ctd:C000488 cladosporin CTD 9.247E-29 7.688E-26 8.117E-25 1.999E-24 20 53
27 CID004634234 3-amino-4-phenylbutan-2-ol Stitch 1.083E-28 8.668E-26 9.152E-25 2.340E-24 22 75
28 CID003081257 Peptide 78 Stitch 2.680E-28 2.069E-25 2.184E-24 5.793E-24 24 105
29 ctd:D014051 Toluene 2,4-Diisocyanate CTD 4.521E-28 3.370E-25 3.558E-24 9.772E-24 27 158
30 CID004369451 T1 d Stitch 6.463E-28 4.657E-25 4.917E-24 1.397E-23 27 160
31 CID000065180 7-amino-AMD Stitch 8.153E-28 5.685E-25 6.002E-24 1.762E-23 20 58
32 CID000003937 AC1L1H1Q Stitch 2.172E-27 1.467E-24 1.549E-23 4.694E-23 27 167
33 CID000040846 Muramyl dipeptide Stitch 1.653E-26 1.083E-23 1.143E-22 3.572E-22 24 123
34 CID000005372 NSC717865 Stitch 2.073E-26 1.318E-23 1.392E-22 4.482E-22 35 388
35 CID000445722 AC1L9IGO Stitch 3.292E-26 2.030E-23 2.143E-22 7.115E-22 27 184
36 ctd:D009183 Mycotoxins CTD 3.381E-26 2.030E-23 2.143E-22 7.307E-22 20 68
37 CID000521017 HPCs Stitch 3.589E-26 2.097E-23 2.214E-22 7.759E-22 26 164
38 CID010447660 IL-1R antagonist Stitch 4.838E-26 2.752E-23 2.905E-22 1.046E-21 22 96
39 ctd:C006794 brevianamide A CTD 6.324E-26 3.505E-23 3.700E-22 1.367E-21 18 48
40 ctd:D009173 Mycophenolic Acid CTD 1.607E-25 8.686E-23 9.171E-22 3.475E-21 23 117
41 ctd:D010476 Perfume CTD 3.400E-25 1.793E-22 1.893E-21 7.350E-21 21 89
42 CID006914627 3 Ig Stitch 4.126E-25 2.124E-22 2.242E-21 8.919E-21 15 27
43 ctd:D011070 Poly I-C CTD 5.208E-25 2.618E-22 2.764E-21 1.126E-20 22 106
44 CID000002304 AC1L1DDL Stitch 1.011E-24 4.967E-22 5.244E-21 2.185E-20 20 79
45 CID000000899 N-acetylhexosamine Stitch 1.250E-24 6.003E-22 6.338E-21 2.701E-20 36 472
46 CID000006574 beta T Stitch 2.521E-24 1.159E-21 1.224E-20 5.448E-20 18 57
47 CID005287950 AC1NRAKH Stitch 2.521E-24 1.159E-21 1.224E-20 5.448E-20 18 57
48 CID000003653 AC1L1GEZ Stitch 7.256E-24 3.245E-21 3.427E-20 1.568E-19 26 200
49 CID000060737 loxoribine Stitch 7.357E-24 3.245E-21 3.427E-20 1.590E-19 18 60
50 CID000066693 CD-III Stitch 3.617E-23 1.564E-20 1.651E-19 7.818E-19 17 53
Show 45 more annotations

18: Disease [Display Chart] 186 input genes in category / 3767 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0013595 Eczema DisGeNET Curated 9.908E-46 3.733E-42 3.289E-41 3.733E-42 58 438
2 C0011615 Dermatitis, Atopic DisGeNET Curated 1.699E-43 3.201E-40 2.821E-39 6.402E-40 55 411
3 C0024138 Lupus Erythematosus, Discoid DisGeNET Curated 5.124E-40 6.433E-37 5.669E-36 1.930E-36 47 303
4 C0398650 Immune thrombocytopenic purpura DisGeNET Curated 2.076E-38 1.955E-35 1.723E-34 7.820E-35 38 172
5 C0409974 Lupus Erythematosus DisGeNET BeFree 7.187E-38 5.415E-35 4.771E-34 2.707E-34 45 296
6 C0018133 Graft-vs-Host Disease DisGeNET Curated 3.653E-37 2.293E-34 2.021E-33 1.376E-33 40 216
7 C0024131 Lupus Vulgaris DisGeNET BeFree 9.602E-36 5.168E-33 4.553E-32 3.617E-32 43 289
8 C0023493 Adult T-Cell Lymphoma/Leukemia DisGeNET Curated 1.667E-35 7.849E-33 6.916E-32 6.279E-32 52 497
9 C0155877 Allergic asthma DisGeNET BeFree 1.330E-34 5.566E-32 4.905E-31 5.010E-31 37 197
10 C0032285 Pneumonia DisGeNET Curated 3.615E-34 1.362E-31 1.200E-30 1.362E-30 50 476
11 C0009447 Common Variable Immunodeficiency DisGeNET Curated 8.383E-34 2.871E-31 2.530E-30 3.158E-30 31 119
12 C0008312 Primary biliary cirrhosis DisGeNET Curated 5.161E-33 1.620E-30 1.428E-29 1.944E-29 40 272
13 C0014070 Encephalomyelitis DisGeNET BeFree 2.663E-32 7.715E-30 6.798E-29 1.003E-28 43 347
14 C0024530 Malaria DisGeNET Curated 3.472E-32 9.015E-30 7.944E-29 1.308E-28 48 470
15 C0004943 Behcet Syndrome DisGeNET Curated 3.590E-32 9.015E-30 7.944E-29 1.352E-28 36 210
16 C0024143 Lupus Nephritis DisGeNET Curated 6.805E-32 1.602E-29 1.412E-28 2.564E-28 34 180
17 C0018213 Graves Disease DisGeNET Curated 2.172E-30 4.812E-28 4.240E-27 8.180E-27 40 316
18 C3539909 Allergic disposition DisGeNET BeFree 3.025E-30 6.331E-28 5.579E-27 1.140E-26 37 256
19 C0524910 Hepatitis C, Chronic DisGeNET Curated 4.188E-30 8.303E-28 7.316E-27 1.578E-26 42 367
20 C0026896 Myasthenia Gravis DisGeNET Curated 4.524E-30 8.520E-28 7.508E-27 1.704E-26 32 169
21 C0011603 Dermatitis DisGeNET Curated 9.955E-30 1.786E-27 1.573E-26 3.750E-26 32 173
22 C3875321 Inflammatory dermatosis DisGeNET BeFree 4.554E-29 7.797E-27 6.870E-26 1.715E-25 30 149
23 C0149678 Epstein-Barr Virus Infections DisGeNET BeFree 2.829E-28 4.633E-26 4.083E-25 1.066E-24 34 228
24 C0041327 Tuberculosis, Pulmonary DisGeNET Curated 3.592E-28 5.638E-26 4.968E-25 1.353E-24 30 159
25 C1527336 Sjogren's Syndrome DisGeNET Curated 2.827E-27 4.260E-25 3.754E-24 1.065E-23 33 224
26 C0079773 Lymphoma, T-Cell, Cutaneous DisGeNET Curated 4.445E-27 6.440E-25 5.675E-24 1.675E-23 34 247
27 C1292769 Precursor B-cell lymphoblastic leukemia DisGeNET BeFree 7.406E-27 1.033E-24 9.104E-24 2.790E-23 42 441
28 C1519680 Tumor Immunity DisGeNET BeFree 2.517E-26 3.386E-24 2.984E-23 9.482E-23 27 133
29 C0023343 Leprosy DisGeNET Curated 2.197E-25 2.854E-23 2.514E-22 8.276E-22 26 128
30 C0850666 helicobacter pylori infection DisGeNET BeFree 8.758E-25 1.100E-22 9.690E-22 3.299E-21 35 312
31 C0036690 Septicemia DisGeNET Curated 1.980E-24 2.406E-22 2.120E-21 7.459E-21 40 450
32 C0524909 Hepatitis B, Chronic DisGeNET Curated 6.106E-24 7.188E-22 6.333E-21 2.300E-20 30 218
33 C0006271 Bronchiolitis DisGeNET Curated 6.966E-24 7.952E-22 7.006E-21 2.624E-20 19 54
34 C0024314 Lymphoproliferative Disorders DisGeNET Curated 9.196E-24 9.907E-22 8.729E-21 3.464E-20 29 201
35 C0243026 Sepsis DisGeNET Curated 9.205E-24 9.907E-22 8.729E-21 3.467E-20 41 498
36 C0221026 X-linked agammaglobulinemia DisGeNET Curated 1.579E-23 1.653E-21 1.456E-20 5.949E-20 19 56
37 C0856825 Acute GVH disease DisGeNET BeFree 2.563E-23 2.609E-21 2.299E-20 9.654E-20 27 170
38 C0867389 Chronic graft-versus-host disease DisGeNET BeFree 2.937E-23 2.912E-21 2.566E-20 1.107E-19 23 106
39 C0014457 Eosinophilia DisGeNET Curated 9.110E-23 8.800E-21 7.754E-20 3.432E-19 27 178
40 C3714757 Juvenile rheumatoid arthritis DisGeNET Curated 1.067E-22 1.005E-20 8.855E-20 4.020E-19 24 127
41 C0241910 Hepatitis, Autoimmune DisGeNET Curated 1.418E-22 1.303E-20 1.148E-19 5.343E-19 23 113
42 C0339143 Thyroid associated opthalmopathies DisGeNET Curated 1.724E-22 1.546E-20 1.363E-19 6.495E-19 21 86
43 C0027430 Nasal Polyps DisGeNET Curated 2.352E-22 2.060E-20 1.815E-19 8.859E-19 28 204
44 C0007570 Celiac Disease DisGeNET Curated 2.541E-22 2.175E-20 1.917E-19 9.571E-19 30 247
45 C0026946 Mycoses DisGeNET BeFree 3.225E-22 2.699E-20 2.379E-19 1.215E-18 30 249
46 C0043144 Wheezing DisGeNET BeFree 6.308E-22 5.166E-20 4.552E-19 2.376E-18 21 91
47 C1306759 Eosinophilic disorder DisGeNET BeFree 1.316E-21 1.055E-19 9.292E-19 4.956E-18 25 158
48 C0242584 Autoimmune thrombocytopenia DisGeNET Curated 2.056E-21 1.614E-19 1.422E-18 7.746E-18 19 70
49 C0010823 Cytomegalovirus Infections DisGeNET Curated 2.246E-21 1.727E-19 1.522E-18 8.462E-18 30 266
50 C0036202 Sarcoidosis DisGeNET Curated 4.241E-21 3.195E-19 2.816E-18 1.598E-17 27 205
Show 45 more annotations