|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
20301621
|
Peroxisome Biogenesis Disorders, Zellweger Syndrome Spectrum
|
Pubmed
|
3.932E-37
|
2.816E-34
|
2.014E-33
|
2.816E-34
|
11
|
13
|
2
|
24501781
|
Leukodystrophy Overview
|
Pubmed
|
2.098E-34
|
7.510E-32
|
5.371E-31
|
1.502E-31
|
13
|
55
|
3
|
10704444
|
PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis.
|
Pubmed
|
1.167E-27
|
2.784E-25
|
1.991E-24
|
8.353E-25
|
9
|
16
|
4
|
12096124
|
Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay.
|
Pubmed
|
3.509E-27
|
6.281E-25
|
4.492E-24
|
2.512E-24
|
8
|
9
|
5
|
21525035
|
PEX14 is required for microtubule-based peroxisome motility in human cells.
|
Pubmed
|
5.712E-25
|
8.180E-23
|
5.850E-22
|
4.090E-22
|
10
|
54
|
6
|
11390669
|
Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences.
|
Pubmed
|
3.015E-20
|
3.598E-18
|
2.573E-17
|
2.159E-17
|
6
|
7
|
7
|
19105186
|
Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.
|
Pubmed
|
1.265E-17
|
1.294E-15
|
9.257E-15
|
9.061E-15
|
5
|
5
|
8
|
9922452
|
Peroxisome synthesis in the absence of preexisting peroxisomes.
|
Pubmed
|
2.656E-16
|
2.377E-14
|
1.700E-13
|
1.902E-13
|
5
|
7
|
9
|
22002062
|
Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix.
|
Pubmed
|
1.613E-15
|
1.284E-13
|
9.179E-13
|
1.155E-12
|
6
|
28
|
10
|
10562279
|
PEX12 interacts with PEX5 and PEX10 and acts downstream of receptor docking in peroxisomal matrix protein import.
|
Pubmed
|
3.452E-14
|
2.472E-12
|
1.768E-11
|
2.472E-11
|
4
|
4
|
11
|
10837480
|
Molecular anatomy of the peroxin Pex12p: ring finger domain is essential for Pex12p function and interacts with the peroxisome-targeting signal type 1-receptor Pex5p and a ring peroxin, Pex10p.
|
Pubmed
|
1.725E-13
|
1.030E-11
|
7.363E-11
|
1.235E-10
|
4
|
5
|
12
|
11883941
|
Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly.
|
Pubmed
|
1.725E-13
|
1.030E-11
|
7.363E-11
|
1.235E-10
|
4
|
5
|
13
|
20531392
|
The peroxisomal receptor Pex19p forms a helical mPTS recognition domain.
|
Pubmed
|
2.414E-12
|
1.329E-10
|
9.507E-10
|
1.728E-9
|
4
|
8
|
14
|
14709540
|
PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins.
|
Pubmed
|
7.236E-12
|
3.701E-10
|
2.647E-9
|
5.181E-9
|
4
|
10
|
15
|
14561759
|
Proteomic analysis of rat liver peroxisome: presence of peroxisome-specific isozyme of Lon protease.
|
Pubmed
|
6.260E-11
|
2.247E-9
|
1.607E-8
|
4.483E-8
|
4
|
16
|
16
|
9653144
|
Identification of a human PTS1 receptor docking protein directly required for peroxisomal protein import.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
17
|
16257970
|
Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
18
|
19584060
|
Solution structure of human Pex5.Pex14.PTS1 protein complexes obtained by small angle X-ray scattering.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
19
|
27311714
|
Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
20
|
19197237
|
Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
21
|
25016021
|
AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
22
|
15713480
|
Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
23
|
28765278
|
The peroxisomal matrix protein translocon is a large cavity-forming protein assembly into which PEX5 protein enters to release its cargo.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
24
|
12717447
|
The pathogenic peroxin Pex26p recruits the Pex1p-Pex6p AAA ATPase complexes to peroxisomes.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
25
|
16449325
|
Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundance.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
26
|
14715663
|
Potential role for Pex19p in assembly of PTS-receptor docking complexes.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
27
|
16854980
|
Dynamic and functional assembly of the AAA peroxins, Pex1p and Pex6p, and their membrane receptor Pex26p.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
28
|
21375735
|
The Peroxisomal Targeting Signal 1 in sterol carrier protein 2 is autonomous and essential for receptor recognition.
|
Pubmed
|
8.789E-11
|
2.247E-9
|
1.607E-8
|
6.293E-8
|
3
|
3
|
29
|
10777694
|
Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p.
|
Pubmed
|
3.514E-10
|
8.117E-9
|
5.805E-8
|
2.516E-7
|
3
|
4
|
30
|
11865044
|
Peroxisomal targeting signal receptor Pex5p interacts with cargoes and import machinery components in a spatiotemporally differentiated manner: conserved Pex5p WXXXF/Y motifs are critical for matrix protein import.
|
Pubmed
|
3.514E-10
|
8.117E-9
|
5.805E-8
|
2.516E-7
|
3
|
4
|
31
|
21102411
|
Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p.
|
Pubmed
|
3.514E-10
|
8.117E-9
|
5.805E-8
|
2.516E-7
|
3
|
4
|
32
|
19479899
|
Pex3p-dependent peroxisomal biogenesis initiates in the endoplasmic reticulum of human fibroblasts.
|
Pubmed
|
8.784E-10
|
1.965E-8
|
1.406E-7
|
6.289E-7
|
3
|
5
|
33
|
17881773
|
Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis.
|
Pubmed
|
1.756E-9
|
3.810E-8
|
2.725E-7
|
1.257E-6
|
3
|
6
|
34
|
10504404
|
The four murine peroxisomal ABC-transporter genes differ in constitutive, inducible and developmental expression.
|
Pubmed
|
3.072E-9
|
6.470E-8
|
4.627E-7
|
2.200E-6
|
3
|
7
|
35
|
20178365
|
A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.
|
Pubmed
|
4.631E-9
|
9.475E-8
|
6.776E-7
|
3.316E-6
|
4
|
44
|
36
|
17208939
|
Mitochondrial phosphoproteome revealed by an improved IMAC method and MS/MS/MS.
|
Pubmed
|
6.631E-9
|
1.319E-7
|
9.431E-7
|
4.748E-6
|
4
|
48
|
37
|
11171065
|
Prenatal and postnatal development of peroxisomal lipid-metabolizing pathways in the mouse.
|
Pubmed
|
1.052E-8
|
2.037E-7
|
1.457E-6
|
7.536E-6
|
3
|
10
|
38
|
24235149
|
A novel Pex14 protein-interacting site of human Pex5 is critical for matrix protein import into peroxisomes.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
39
|
16280322
|
In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
40
|
27302843
|
Spectrum of PEX1 and PEX6 variants in Heimler syndrome.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
41
|
22529745
|
Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
42
|
9288097
|
A mouse model for Zellweger syndrome.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
43
|
22624858
|
The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
44
|
8858165
|
Pex13p is an SH3 protein of the peroxisome membrane and a docking factor for the predominantly cytoplasmic PTs1 receptor.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
45
|
19715730
|
The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
46
|
25062251
|
Association between the intrinsically disordered protein PEX19 and PEX3.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
47
|
11453642
|
Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
48
|
16895967
|
Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
49
|
9398847
|
Mutations in PEX1 are the most common cause of peroxisome biogenesis disorders.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|
50
|
27633571
|
Severe early onset retinitis pigmentosa in a Moroccan patient with Heimler syndrome due to novel homozygous mutation of PEX1 gene.
|
Pubmed
|
2.098E-7
|
2.242E-6
|
1.603E-5
|
1.502E-4
|
2
|
2
|