Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc150_13, positive side

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1: GO: Molecular Function [Display Chart] 13 input genes in category / 62 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034061 DNA polymerase activity 2.483E-8 1.540E-6 7.255E-6 1.540E-6 4 47
2 GO:0003887 DNA-directed DNA polymerase activity 8.566E-7 2.655E-5 1.251E-4 5.311E-5 3 28
3 GO:0016779 nucleotidyltransferase activity 1.628E-6 3.364E-5 1.585E-4 1.009E-4 4 132
4 GO:0017125 deoxycytidyl transferase activity 6.966E-4 8.638E-3 4.071E-2 4.319E-2 1 1
5 GO:0003912 DNA nucleotidylexotransferase activity 6.966E-4 8.638E-3 4.071E-2 4.319E-2 1 1
6 GO:0003684 damaged DNA binding 9.091E-4 9.394E-3 4.427E-2
5.636E-2
 2 65
7 GO:0003910 DNA ligase (ATP) activity 4.173E-3 1.762E-2
8.305E-2
2.587E-1
 1 6
8 GO:0035312 5'-3' exodeoxyribonuclease activity 4.173E-3 1.762E-2
8.305E-2
2.587E-1
 1 6
9 GO:0008420 RNA polymerase II CTD heptapeptide repeat phosphatase activity 4.173E-3 1.762E-2
8.305E-2
2.587E-1
 1 6
10 GO:0043814 phospholactate guanylyltransferase activity 4.867E-3 1.762E-2
8.305E-2
3.018E-1
 1 7
11 GO:0003909 DNA ligase activity 4.867E-3 1.762E-2
8.305E-2
3.018E-1
 1 7
12 GO:0052630 UDP-N-acetylgalactosamine diphosphorylase activity 4.867E-3 1.762E-2
8.305E-2
3.018E-1
 1 7
13 GO:0043910 ATP:coenzyme F420 adenylyltransferase activity 4.867E-3 1.762E-2
8.305E-2
3.018E-1
 1 7
14 GO:0043338 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity 4.867E-3 1.762E-2
8.305E-2
3.018E-1
 1 7
15 GO:0003896 DNA primase activity 5.561E-3 1.762E-2
8.305E-2
3.448E-1
 1 8
16 GO:0008905 mannose-phosphate guanylyltransferase activity 5.561E-3 1.762E-2
8.305E-2
3.448E-1
 1 8
17 GO:0000014 single-stranded DNA endodeoxyribonuclease activity 5.561E-3 1.762E-2
8.305E-2
3.448E-1
 1 8
18 GO:0033170 protein-DNA loading ATPase activity 6.254E-3 1.762E-2
8.305E-2
3.877E-1
 1 9
19 GO:0004779 sulfate adenylyltransferase activity 6.254E-3 1.762E-2
8.305E-2
3.877E-1
 1 9
20 GO:0008193 tRNA guanylyltransferase activity 6.254E-3 1.762E-2
8.305E-2
3.877E-1
 1 9
21 GO:0003689 DNA clamp loader activity 6.254E-3 1.762E-2
8.305E-2
3.877E-1
 1 9
22 GO:0033677 DNA/RNA helicase activity 6.254E-3 1.762E-2
8.305E-2
3.877E-1
 1 9
23 GO:0008192 RNA guanylyltransferase activity 6.946E-3 1.794E-2
8.456E-2
4.307E-1
 1 10
24 GO:0016886 ligase activity, forming phosphoric ester bonds 6.946E-3 1.794E-2
8.456E-2
4.307E-1
 1 10
25 GO:0070568 guanylyltransferase activity 8.330E-3 2.066E-2
9.735E-2
5.165E-1
 1 12
26 GO:0070182 DNA polymerase binding 9.021E-3 2.072E-2
9.762E-2
5.593E-1
 1 13
27 GO:0070569 uridylyltransferase activity 9.021E-3 2.072E-2
9.762E-2
5.593E-1
 1 13
28 GO:0003720 telomerase activity 9.712E-3 2.150E-2
1.013E-1
6.022E-1
 1 14
29 GO:0008022 protein C-terminus binding 1.026E-2 2.150E-2
1.013E-1
6.358E-1
 2 224
30 GO:0070567 cytidylyltransferase activity 1.040E-2 2.150E-2
1.013E-1
6.450E-1
 1 15
31 GO:0004529 exodeoxyribonuclease activity 1.247E-2 2.343E-2
1.104E-1
7.732E-1
 1 18
32 GO:0016895 exodeoxyribonuclease activity, producing 5'-phosphomonoesters 1.247E-2 2.343E-2
1.104E-1
7.732E-1
 1 18
33 GO:0008409 5'-3' exonuclease activity 1.247E-2 2.343E-2
1.104E-1
7.732E-1
 1 18
34 GO:0003964 RNA-directed DNA polymerase activity 1.454E-2 2.651E-2
1.249E-1
9.012E-1
 1 21
35 GO:0003950 NAD+ ADP-ribosyltransferase activity 1.797E-2 3.183E-2
1.500E-1
1.000E0
 1 26
36 GO:0070566 adenylyltransferase activity 2.139E-2 3.684E-2
1.736E-1
1.000E0
 1 31
Show 31 more annotations

2: GO: Biological Process [Display Chart] 13 input genes in category / 306 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071897 DNA biosynthetic process 3.514E-11 1.075E-8 6.778E-8 1.075E-8 7 211
2 GO:0002200 somatic diversification of immune receptors 7.577E-10 7.728E-8 4.871E-7 2.319E-7 5 69
3 GO:0006303 double-strand break repair via nonhomologous end joining 7.577E-10 7.728E-8 4.871E-7 2.319E-7 5 69
4 GO:0000726 non-recombinational repair 1.242E-9 9.505E-8 5.990E-7 3.802E-7 5 76
5 GO:0006310 DNA recombination 1.295E-8 7.927E-7 4.996E-6 3.963E-6 6 267
6 GO:0016445 somatic diversification of immunoglobulins 4.772E-8 2.434E-6 1.534E-5 1.460E-5 4 55
7 GO:0006260 DNA replication 6.056E-8 2.647E-6 1.668E-5 1.853E-5 6 346
8 GO:0006302 double-strand break repair 1.475E-7 5.641E-6 3.555E-5 4.513E-5 5 196
9 GO:0002377 immunoglobulin production 6.313E-7 2.146E-5 1.353E-4 1.932E-4 4 104
10 GO:0010212 response to ionizing radiation 3.276E-6 1.003E-4 6.318E-4 1.003E-3 4 157
11 GO:0002440 production of molecular mediator of immune response 5.515E-6 1.534E-4 9.669E-4 1.688E-3 4 179
12 GO:0016444 somatic cell DNA recombination 8.887E-6 2.092E-4 1.318E-3 2.719E-3 3 60
13 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus 8.887E-6 2.092E-4 1.318E-3 2.719E-3 3 60
14 GO:0009314 response to radiation 1.208E-5 2.641E-4 1.665E-3 3.697E-3 5 480
15 GO:0042113 B cell activation 2.297E-5 4.686E-4 2.953E-3 7.029E-3 4 257
16 GO:0016446 somatic hypermutation of immunoglobulin genes 5.368E-5 1.027E-3 6.471E-3 1.643E-2 2 16
17 GO:0002566 somatic diversification of immune receptors via somatic mutation 6.082E-5 1.095E-3 6.899E-3 1.861E-2 2 17
18 GO:0033151 V(D)J recombination 6.839E-5 1.118E-3 7.048E-3 2.093E-2 2 18
19 GO:0006289 nucleotide-excision repair 6.944E-5 1.118E-3 7.048E-3 2.125E-2 3 119
20 GO:0042276 error-prone translesion synthesis 7.641E-5 1.169E-3 7.368E-3 2.338E-2 2 19
21 GO:0006261 DNA-dependent DNA replication 9.883E-5 1.440E-3 9.076E-3 3.024E-2 3 134
22 GO:0000723 telomere maintenance 1.125E-4 1.565E-3 9.866E-3 3.444E-2 3 140
23 GO:0006297 nucleotide-excision repair, DNA gap filling 1.231E-4 1.638E-3 1.032E-2 3.766E-2 2 24
24 GO:0032200 telomere organization 1.464E-4 1.867E-3 1.176E-2 4.480E-2 3 153
25 GO:0019985 translesion synthesis 3.632E-4 4.167E-3 2.626E-2
1.112E-1
 2 41
26 GO:0045190 isotype switching 3.813E-4 4.167E-3 2.626E-2
1.167E-1
 2 42
27 GO:0002204 somatic recombination of immunoglobulin genes involved in immune response 3.813E-4 4.167E-3 2.626E-2
1.167E-1
 2 42
28 GO:0002208 somatic diversification of immunoglobulins involved in immune response 3.813E-4 4.167E-3 2.626E-2
1.167E-1
 2 42
29 GO:0016447 somatic recombination of immunoglobulin gene segments 4.777E-4 5.041E-3 3.177E-2
1.462E-1
 2 47
30 GO:0002381 immunoglobulin production involved in immunoglobulin mediated immune response 6.075E-4 6.197E-3 3.906E-2
1.859E-1
 2 53
31 GO:0006301 postreplication repair 6.307E-4 6.225E-3 3.923E-2
1.930E-1
 2 54
32 GO:0007004 telomere maintenance via telomerase 6.782E-4 6.283E-3 3.960E-2
2.075E-1
 2 56
33 GO:0051102 DNA ligation involved in DNA recombination 6.981E-4 6.283E-3 3.960E-2
2.136E-1
 1 1
34 GO:0000416 positive regulation of histone H3-K36 methylation 6.981E-4 6.283E-3 3.960E-2
2.136E-1
 1 1
35 GO:0002312 B cell activation involved in immune response 9.127E-4 7.758E-3 4.890E-2
2.793E-1
 2 65
36 GO:0006278 RNA-dependent DNA biosynthetic process 9.127E-4 7.758E-3 4.890E-2
2.793E-1
 2 65
37 GO:0010833 telomere maintenance via telomere lengthening 9.409E-4 7.781E-3 4.904E-2
2.879E-1
 2 66
38 GO:0000731 DNA synthesis involved in DNA repair 1.213E-3 9.767E-3
6.156E-2
3.711E-1
 2 75
39 GO:0030098 lymphocyte differentiation 1.718E-3 1.348E-2
8.496E-2
5.257E-1
 3 356
40 GO:0097680 double-strand break repair via classical nonhomologous end joining 2.093E-3 1.601E-2
1.009E-1
6.404E-1
 1 3
41 GO:0002250 adaptive immune response 2.430E-3 1.771E-2
1.116E-1
7.437E-1
 3 402
42 GO:0060249 anatomical structure homeostasis 2.430E-3 1.771E-2
1.116E-1
7.437E-1
 3 402
43 GO:0000414 regulation of histone H3-K36 methylation 2.790E-3 1.985E-2
1.251E-1
8.536E-1
 1 4
44 GO:0033152 immunoglobulin V(D)J recombination 3.486E-3 2.162E-2
1.363E-1
1.000E0
 1 5
45 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain 3.486E-3 2.162E-2
1.363E-1
1.000E0
 1 5
46 GO:0002568 somatic diversification of T cell receptor genes 3.486E-3 2.162E-2
1.363E-1
1.000E0
 1 5
47 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development 3.486E-3 2.162E-2
1.363E-1
1.000E0
 1 5
48 GO:0002681 somatic recombination of T cell receptor gene segments 3.486E-3 2.162E-2
1.363E-1
1.000E0
 1 5
49 GO:0033153 T cell receptor V(D)J recombination 3.486E-3 2.162E-2
1.363E-1
1.000E0
 1 5
50 GO:0030183 B cell differentiation 3.533E-3 2.162E-2
1.363E-1
1.000E0
 2 129
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 13 input genes in category / 44 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070419 nonhomologous end joining complex 1.542E-5 6.783E-4 2.966E-3 6.783E-4 2 9
2 GO:0000793 condensed chromosome 3.379E-4 6.409E-3 2.802E-2 1.487E-2 3 208
3 GO:1990391 DNA repair complex 4.370E-4 6.409E-3 2.802E-2 1.923E-2 2 46
4 GO:0005819 spindle 1.060E-3 1.166E-2
5.097E-2
 4.662E-2 3 308
5 GO:0032807 DNA ligase IV complex 1.364E-3 1.200E-2
5.247E-2
6.000E-2
 1 2
6 GO:0070545 PeBoW complex 2.045E-3 1.416E-2
6.194E-2
8.997E-2
 1 3
7 GO:0016363 nuclear matrix 2.253E-3 1.416E-2
6.194E-2
9.915E-2
 2 105
8 GO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex 2.726E-3 1.476E-2
6.454E-2
1.199E-1
 1 4
9 GO:0000922 spindle pole 3.584E-3 1.476E-2
6.454E-2
1.577E-1
 2 133
10 GO:0000784 nuclear chromosome, telomeric region 3.584E-3 1.476E-2
6.454E-2
1.577E-1
 2 133
11 GO:0034399 nuclear periphery 3.690E-3 1.476E-2
6.454E-2
1.624E-1
 2 135
12 GO:0005663 DNA replication factor C complex 4.086E-3 1.498E-2
6.551E-2
1.798E-1
 1 6
13 GO:0000781 chromosome, telomeric region 5.266E-3 1.782E-2
7.793E-2
2.317E-1
 2 162
14 GO:0044666 MLL3/4 complex 6.123E-3 1.924E-2
8.414E-2
2.694E-1
 1 9
15 GO:0001673 male germ cell nucleus 1.423E-2 4.175E-2
1.826E-1
6.262E-1
 1 21
16 GO:0030687 preribosome, large subunit precursor 1.692E-2 4.465E-2
1.952E-1
7.446E-1
 1 25
17 GO:0043073 germ cell nucleus 1.826E-2 4.465E-2
1.952E-1
8.036E-1
 1 27
18 GO:0030686 90S preribosome 1.826E-2 4.465E-2
1.952E-1
8.036E-1
 1 27
19 GO:0051233 spindle midzone 2.027E-2 4.695E-2
2.053E-1
8.921E-1
 1 30
20 GO:0098687 chromosomal region 2.221E-2 4.887E-2
2.137E-1
9.774E-1
 2 344
Show 15 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 641 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007549 Desquamation of skin soon after birth 2.839E-5 1.818E-2
1.280E-1
 1.820E-2 2 15
2 HP:0003075 Hypoproteinemia 5.673E-5 1.818E-2
1.280E-1
 3.636E-2 2 21
3 HP:0000778 Hypoplasia of the thymus 1.254E-4 2.424E-2
1.707E-1
8.040E-2
 2 31
4 HP:0010515 Aplasia/Hypoplasia of the thymus 1.513E-4 2.424E-2
1.707E-1
9.696E-2
 2 34
5 HP:0001019 Erythroderma 2.909E-4 3.393E-2
2.389E-1
1.865E-1
 2 47
6 HP:0002841 Recurrent fungal infections 3.296E-4 3.393E-2
2.389E-1
2.112E-1
 2 50
7 HP:0005365 Severe B lymphocytopenia 3.706E-4 3.393E-2
2.389E-1
2.375E-1
 2 53
8 HP:0010976 B lymphocytopenia 6.113E-4 3.868E-2
2.724E-1
3.918E-1
 2 68
9 HP:0010975 Abnormal B cell count 6.294E-4 3.868E-2
2.724E-1
4.035E-1
 2 69
10 HP:0030813 Absent tonsils 6.373E-4 3.868E-2
2.724E-1
4.085E-1
 1 1
11 HP:0000777 Abnormality of the thymus 7.047E-4 3.868E-2
2.724E-1
4.517E-1
 2 73
12 HP:0007423 Skin inflammation 7.241E-4 3.868E-2
2.724E-1
4.642E-1
 2 74
13 HP:0001831 Short toe 8.678E-4 4.279E-2
3.013E-1
5.562E-1
 2 81
Show 8 more annotations

5: Mouse Phenotype [Display Chart] 11 input genes in category / 281 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008755 abnormal immunoglobulin V(D)J recombination 4.087E-9 1.149E-6 7.141E-6 1.149E-6 4 21
2 MP:0008761 abnormal immunoglobulin light chain V-J recombination 8.909E-9 1.252E-6 7.782E-6 2.503E-6 3 5
3 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination 4.030E-7 3.775E-5 2.347E-4 1.132E-4 3 15
4 MP:0002144 abnormal B cell differentiation 5.437E-7 3.819E-5 2.375E-4 1.528E-4 6 347
5 MP:0008758 abnormal T cell receptor beta chain V(D)J recombination 3.679E-5 2.067E-3 1.285E-2 1.034E-2 2 9
6 MP:0002223 lymphoid hypoplasia 9.272E-5 4.292E-3 2.668E-2 2.605E-2 2 14
7 MP:0000687 small lymphoid organs 1.069E-4 4.292E-3 2.668E-2 3.004E-2 2 15
8 MP:0008754 abnormal T cell receptor V(D)J recombination 1.383E-4 4.859E-3 3.021E-2 3.887E-2 2 17
9 MP:0010847 increased central memory CD8 positive, alpha-beta T cell number 2.564E-4 6.565E-3 4.082E-2
7.206E-2
 2 23
10 MP:0004030 induced chromosome breakage 3.037E-4 6.565E-3 4.082E-2
8.534E-2
 2 25
11 MP:0000727 absent CD8-positive, alpha-beta T cells 3.037E-4 6.565E-3 4.082E-2
8.534E-2
 2 25
12 MP:0012772 abnormal central memory CD8-positive, alpha-beta T cell number 3.037E-4 6.565E-3 4.082E-2
8.534E-2
 2 25
13 MP:0010846 abnormal central memory CD8 positive, alpha-beta T cell morphology 3.037E-4 6.565E-3 4.082E-2
8.534E-2
 2 25
14 MP:0013435 decreased CD8-positive, naive alpha-beta T cell number 5.321E-4 1.052E-2
6.539E-2
1.495E-1
 2 33
15 MP:0009339 decreased splenocyte number 5.650E-4 1.052E-2
6.539E-2
1.588E-1
 2 34
16 MP:0020154 impaired humoral immune response 5.989E-4 1.052E-2
6.539E-2
1.683E-1
 2 35
17 MP:0013434 abnormal CD8-positive, naive alpha-beta T cell number 7.064E-4 1.168E-2
7.259E-2
1.985E-1
 2 38
18 MP:0008217 abnormal B cell activation 1.029E-3 1.531E-2
9.518E-2
2.893E-1
 3 199
19 MP:0004956 decreased thymus weight 1.035E-3 1.531E-2
9.518E-2
2.909E-1
 2 46
20 MP:0010844 increased effector memory CD4-positive, alpha-beta T cell number 1.127E-3 1.583E-2
9.843E-2
3.166E-1
 2 48
21 MP:0005017 decreased B cell number 1.196E-3 1.601E-2
9.951E-2
3.361E-1
 4 484
22 MP:0002007 increased cellular sensitivity to gamma-irradiation 1.477E-3 1.887E-2
1.173E-1
4.152E-1
 2 55
23 MP:0010835 increased CD4-positive, alpha-beta memory T cell number 1.642E-3 1.989E-2
1.236E-1
4.613E-1
 2 58
24 MP:0001825 arrested T cell differentiation 1.698E-3 1.989E-2
1.236E-1
4.772E-1
 2 59
25 MP:0004954 abnormal thymus weight 1.934E-3 1.989E-2
1.237E-1
5.435E-1
 2 63
26 MP:0010843 abnormal effector memory CD4-positive, alpha-beta T cell morphology 1.995E-3 1.989E-2
1.237E-1
5.607E-1
 2 64
27 MP:0012770 abnormal effector memory CD4-positive, alpha-beta T cell number 1.995E-3 1.989E-2
1.237E-1
5.607E-1
 2 64
28 MP:0009337 abnormal splenocyte number 2.057E-3 1.989E-2
1.237E-1
5.782E-1
 2 65
29 MP:0010838 increased CD8-positive, alpha-beta memory T cell number 2.121E-3 1.989E-2
1.237E-1
5.959E-1
 2 66
30 MP:0030046 round forehead 2.124E-3 1.989E-2
1.237E-1
5.967E-1
 1 2
31 MP:0010834 abnormal CD4-positive, alpha-beta memory T cell morphology 2.249E-3 2.039E-2
1.268E-1
6.321E-1
 2 68
32 MP:0001802 arrested B cell differentiation 2.518E-3 2.139E-2
1.330E-1
7.076E-1
 2 72
33 MP:0004028 chromosome breakage 2.518E-3 2.139E-2
1.330E-1
7.076E-1
 2 72
34 MP:0009332 abnormal splenocyte morphology 2.588E-3 2.139E-2
1.330E-1
7.271E-1
 2 73
35 MP:0012769 abnormal CD4-positive, alpha-beta memory T cell number 3.099E-3 2.405E-2
1.496E-1
8.707E-1
 2 80
36 MP:0008044 increased NK cell number 3.099E-3 2.405E-2
1.496E-1
8.707E-1
 2 80
37 MP:0005089 decreased double-negative T cell number 3.253E-3 2.405E-2
1.496E-1
9.140E-1
 2 82
38 MP:0004227 increased cellular sensitivity to ionizing radiation 3.253E-3 2.405E-2
1.496E-1
9.140E-1
 2 82
39 MP:0010837 abnormal CD8-positive, alpha-beta memory T cell morphology 3.736E-3 2.625E-2
1.632E-1
1.000E0
 2 88
40 MP:0012774 abnormal CD8-positive, alpha-beta memory T cell number 3.736E-3 2.625E-2
1.632E-1
1.000E0
 2 88
41 MP:0004816 abnormal class switch recombination 4.164E-3 2.773E-2
1.724E-1
1.000E0
 2 93
42 MP:0010091 decreased circulating creatine kinase level 4.243E-3 2.773E-2
1.724E-1
1.000E0
 1 4
43 MP:0020281 decreased creatine kinase level 4.243E-3 2.773E-2
1.724E-1
1.000E0
 1 4
44 MP:0010250 absent thymus cortex 6.358E-3 4.061E-2
2.525E-1
1.000E0
 1 6
45 MP:0008049 increased memory T cell number 6.622E-3 4.112E-2
2.556E-1
1.000E0
 2 118
46 MP:0008866 chromosomal instability 6.731E-3 4.112E-2
2.556E-1
1.000E0
 2 119
47 MP:0010094 abnormal chromosome stability 6.952E-3 4.156E-2
2.584E-1
1.000E0
 2 121
48 MP:0008058 abnormal DNA repair 7.404E-3 4.334E-2
2.695E-1
1.000E0
 2 125
49 MP:0001556 increased circulating HDL cholesterol level 7.988E-3 4.556E-2
2.833E-1
1.000E0
 2 130
50 MP:0001806 decreased IgM level 8.107E-3 4.556E-2
2.833E-1
1.000E0
 2 131
Show 45 more annotations

6: Domain [Display Chart] 13 input genes in category / 108 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS50172 BRCT PROSITE 2.414E-31 2.607E-29 1.372E-28 2.607E-29 11 26
2 IPR001357 BRCT dom InterPro 6.707E-31 3.622E-29 1.906E-28 7.244E-29 11 28
3 SM00292 BRCT SMART 1.260E-28 4.538E-27 2.389E-26 1.361E-26 10 22
4 3.40.50.10190 - Gene3D 2.230E-28 6.020E-27 3.169E-26 2.408E-26 10 23
5 PF00533 BRCT Pfam 8.429E-26 1.821E-24 9.583E-24 9.103E-24 9 19
6 IPR027421 DNA pol X lyase dom InterPro 2.610E-10 4.027E-9 2.120E-8 2.819E-8 3 3
7 1.10.150.110 - Gene3D 2.610E-10 4.027E-9 2.120E-8 2.819E-8 3 3
8 IPR029398 PolB thumb InterPro 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
9 PF10391 DNA pol lambd f Pfam 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
10 PF14716 HHH 8 Pfam 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
11 IPR019843 DNA pol-X BS InterPro 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
12 PF14791 DNA pol B thumb Pfam 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
13 PF14792 DNA pol B palm Pfam 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
14 PS00522 DNA POLYMERASE X PROSITE 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
15 IPR002054 DNA-dir DNA pol X InterPro 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
16 SM00483 POLXc SMART 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
17 3.30.210.10 - Gene3D 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
18 IPR022312 DNA pol X InterPro 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
19 IPR028207 DNA pol B palm palm InterPro 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
20 IPR018944 DNA pol lambd fingers domain InterPro 1.044E-9 5.635E-9 2.966E-8 1.127E-7 3 4
21 IPR010996 DNA pol b-like N InterPro 2.608E-9 1.341E-8 7.060E-8 2.816E-7 3 5
22 IPR001726 TdT/Mu InterPro 4.445E-7 2.182E-6 1.149E-5 4.800E-5 2 2
23 PF12738 PTCB-BRCT Pfam 2.665E-6 1.251E-5 6.587E-5 2.878E-4 2 4
24 PF16589 BRCT 2 Pfam 4.439E-6 1.998E-5 1.052E-4 4.795E-4 2 5
25 IPR031273 PARP4 InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
26 IPR026993 Topbp1 InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
27 IPR029710 LIG4 InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
28 IPR021536 DNA ligase IV dom InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
29 IPR031991 Rev1 C InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
30 IPR027249 DNA/RNApol mu InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
31 PF09309 FCP1 C Pfam 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
32 PF08519 RFC1 Pfam 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
33 IPR015388 FCP1 C InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
34 PF11411 DNA ligase IV Pfam 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
35 PF16727 REV1 C Pfam 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
36 IPR011947 FCP1 euk InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
37 PF06732 Pescadillo N Pfam 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
38 IPR010613 PES InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
39 IPR027292 TdT InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
40 IPR013725 DNA replication fac RFC1 C InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
41 IPR012178 RFC1 InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
42 IPR012112 REV1 InterPro 6.939E-4 1.784E-3 9.392E-3
7.494E-2
 1 1
43 PF09806 CDK2AP Pfam 1.387E-3 3.121E-3 1.643E-2
1.498E-1
 1 2
44 IPR025527 DUF4414 InterPro 1.387E-3 3.121E-3 1.643E-2
1.498E-1
 1 2
45 IPR002008 DNA pol X beta-like InterPro 1.387E-3 3.121E-3 1.643E-2
1.498E-1
 1 2
46 IPR019187 Cyclin-dep kinase2-assoc pr InterPro 1.387E-3 3.121E-3 1.643E-2
1.498E-1
 1 2
47 IPR017266 CDK2-associated 2 InterPro 1.387E-3 3.121E-3 1.643E-2
1.498E-1
 1 2
48 PF14377 DUF4414 Pfam 1.387E-3 3.121E-3 1.643E-2
1.498E-1
 1 2
49 PS00333 DNA LIGASE A2 PROSITE 2.080E-3 3.566E-3 1.877E-2
2.247E-1
 1 3
50 PF01068 DNA ligase A M Pfam 2.080E-3 3.566E-3 1.877E-2
2.247E-1
 1 3
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 98 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83047 Non-homologous end-joining BioSystems: KEGG 6.622E-13 6.489E-11 3.353E-10 6.489E-11 5 13
2 1309095 DNA Double-Strand Break Repair BioSystems: REACTOME 1.202E-10 5.888E-9 3.042E-8 1.178E-8 7 169
3 1270350 DNA Repair BioSystems: REACTOME 1.960E-10 6.404E-9 3.309E-8 1.921E-8 8 319
4 1309110 Nonhomologous End-Joining (NHEJ) BioSystems: REACTOME 6.040E-9 1.480E-7 7.646E-7 5.919E-7 5 70
5 1270370 Translesion synthesis by REV1 BioSystems: REACTOME 1.198E-4 1.900E-3 9.815E-3 1.174E-2 2 16
6 1270372 Translesion synthesis by POLK BioSystems: REACTOME 1.357E-4 1.900E-3 9.815E-3 1.330E-2 2 17
7 1270373 Translesion synthesis by POLI BioSystems: REACTOME 1.357E-4 1.900E-3 9.815E-3 1.330E-2 2 17
8 83043 Base excision repair BioSystems: KEGG 5.218E-4 6.034E-3 3.118E-2
5.114E-2
 2 33
9 1270374 Termination of translesion DNA synthesis BioSystems: REACTOME 5.541E-4 6.034E-3 3.118E-2
5.430E-2
 2 34
10 1270369 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template BioSystems: REACTOME 8.066E-4 7.905E-3 4.085E-2
7.905E-2
 2 41
11 1270367 DNA Damage Bypass BioSystems: REACTOME 1.199E-3 1.068E-2
5.518E-2
1.175E-1
 2 50
12 1309102 HDR through Homologous Recombination (HRR) BioSystems: REACTOME 2.270E-3 1.854E-2
9.579E-2
2.225E-1
 2 69
Show 7 more annotations

8: Pubmed [Display Chart] 13 input genes in category / 1077 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16860755 Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Pubmed 3.080E-11 3.318E-8 2.508E-7 3.318E-8 3 3
2 25512557 PTIP associates with Artemis to dictate DNA repair pathway choice. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
3 23967291 DNA ligase IV and artemis act cooperatively to suppress homologous recombination in human cells: implications for DNA double-strand break repair. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
4 23935073 A specific N-terminal extension of the 8 kDa domain is required for DNA end-bridging by human Polμ and Polλ. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
5 10747040 DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
6 26240371 Essential role for polymerase specialization in cellular nonhomologous end joining. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
7 11974916 [Expression and function of terminal deoxynucleotidyl-transferase and discovery of novel DNA polymerase mu]. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
8 11937519 Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
9 19805281 Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
10 10982892 Two novel human and mouse DNA polymerases of the polX family. Pubmed 1.069E-7 1.152E-5 8.707E-5 1.152E-4 2 2
11 23219551 Structural basis of DNA ligase IV-Artemis interaction in nonhomologous end-joining. Pubmed 3.208E-7 2.483E-5 1.877E-4 3.455E-4 2 3
12 28696258 Effects of DNA end configuration on XRCC4-DNA ligase IV and its stimulation of Artemis activity. Pubmed 3.208E-7 2.483E-5 1.877E-4 3.455E-4 2 3
13 12077346 Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Pubmed 3.208E-7 2.483E-5 1.877E-4 3.455E-4 2 3
14 19074885 Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia. Pubmed 3.227E-7 2.483E-5 1.877E-4 3.476E-4 4 179
15 21160476 H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Pubmed 6.414E-7 4.064E-5 3.072E-4 6.908E-4 2 4
16 22529269 Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs. Pubmed 6.414E-7 4.064E-5 3.072E-4 6.908E-4 2 4
17 15609317 Association of amino acid substitution polymorphisms in DNA repair genes TP53, POLI, REV1 and LIG4 with lung cancer risk. Pubmed 6.414E-7 4.064E-5 3.072E-4 6.908E-4 2 4
18 18270339 Comprehensive analysis of DNA repair gene variants and risk of meningioma. Pubmed 8.918E-7 5.336E-5 4.034E-4 9.605E-4 3 57
19 20975951 Ancient and recent adaptive evolution of primate non-homologous end joining genes. Pubmed 1.069E-6 5.756E-5 4.351E-4 1.151E-3 2 5
20 12846809 The role of DNA breaks in genomic instability and tumorigenesis. Pubmed 1.069E-6 5.756E-5 4.351E-4 1.151E-3 2 5
21 14576433 The BRCT domain is a phospho-protein binding domain. Pubmed 1.603E-6 7.506E-5 5.674E-4 1.726E-3 2 6
22 14657033 Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis. Pubmed 1.603E-6 7.506E-5 5.674E-4 1.726E-3 2 6
23 14576432 BRCT repeats as phosphopeptide-binding modules involved in protein targeting. Pubmed 1.603E-6 7.506E-5 5.674E-4 1.726E-3 2 6
24 20522537 Variation within DNA repair pathway genes and risk of multiple sclerosis. Pubmed 1.890E-6 8.480E-5 6.411E-4 2.035E-3 3 73
25 19237606 Genetic polymorphisms in 85 DNA repair genes and bladder cancer risk. Pubmed 2.889E-6 1.239E-4 9.366E-4 3.111E-3 3 84
26 25941166 XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair. Pubmed 2.991E-6 1.239E-4 9.366E-4 3.221E-3 2 8
27 23901102 BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Pubmed 3.845E-6 1.534E-4 1.159E-3 4.141E-3 2 9
28 19859091 Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country. Pubmed 8.324E-6 3.202E-4 2.420E-3 8.965E-3 2 13
29 17588522 E3-independent monoubiquitination of ubiquitin-binding proteins. Pubmed 1.120E-5 4.160E-4 3.145E-3 1.206E-2 2 15
30 22522401 Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors. Pubmed 2.238E-5 8.033E-4 6.073E-3 2.410E-2 2 21
31 20610542 Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk. Pubmed 3.736E-5 9.776E-4 7.390E-3 4.024E-2 2 27
32 19661089 Genetic variation in immune regulation and DNA repair pathways and stomach cancer in China. Pubmed 4.022E-5 9.776E-4 7.390E-3 4.332E-2 2 28
33 22242598 Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily. Pubmed 1.196E-4 9.776E-4 7.390E-3
1.288E-1
 2 48
34 19536092 Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. Pubmed 1.572E-4 9.776E-4 7.390E-3
1.693E-1
 2 55
35 23254330 Regulation of error-prone translesion synthesis by Spartan/C1orf124. Pubmed 1.810E-4 9.776E-4 7.390E-3
1.949E-1
 2 59
36 20496165 Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. Pubmed 2.406E-4 9.776E-4 7.390E-3
2.591E-1
 2 68
37 20724438 Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
38 11112348 The murine Pes1 gene encodes a nuclear protein containing a BRCT domain. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
39 15731174 Omenn syndrome due to ARTEMIS mutations. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
40 11934899 A Functional interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
41 28973441 Polμ tumor variants decrease the efficiency and accuracy of NHEJ. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
42 20301787 Congenital Cataracts, Facial Dysmorphism, and Neuropathy Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
43 17287259 TopBP1 regulates human papillomavirus type 16 E2 interaction with chromatin. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
44 28930678 DNA Ligase IV Guides End-Processing Choice during Nonhomologous End Joining. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
45 11278384 Deoxycytidyl transferase activity of the human REV1 protein is closely associated with the conserved polymerase domain. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
46 18975621 [Induced mutagenesis and translesion DNA synthesis--structure and function of REV1]. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
47 20088963 PTIP promotes DNA double-strand break repair through homologous recombination. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
48 15611258 Valpha and Vbeta public repertoires are highly conserved in terminal deoxynucleotidyl transferase-deficient mice. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
49 12228225 Lesion bypass activities of human DNA polymerase mu. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
50 12921762 Expansion of clonotype-restricted HLA-identical maternal CD4+ T cells in a patient with severe combined immunodeficiency and a homozygous mutation in the Artemis gene. Pubmed 3.404E-4 9.776E-4 7.390E-3
3.666E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 13 input genes in category / 762 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NBN NBN interactions 6.076E-7 4.630E-4 3.340E-3 4.630E-4 4 98
2 int:PCNA PCNA interactions 2.137E-6 8.143E-4 5.874E-3 1.629E-3 5 320
3 int:ATM ATM interactions 9.832E-6 2.497E-3 1.801E-2 7.492E-3 4 197
4 int:SMC2 SMC2 interactions 3.503E-5 6.672E-3 4.813E-2 2.669E-2 3 90
5 int:XRCC6 XRCC6 interactions 7.598E-5 9.921E-3
7.157E-2
5.790E-2
 4 332
6 int:RAD50 RAD50 interactions 8.897E-5 9.921E-3
7.157E-2
6.779E-2
 3 123
7 int:ATR ATR interactions 9.114E-5 9.921E-3
7.157E-2
6.945E-2
 3 124
8 int:CDC27 CDC27 interactions 1.199E-4 9.955E-3
7.181E-2
9.135E-2
 3 136
9 int:MRE11 MRE11 interactions 1.225E-4 9.955E-3
7.181E-2
9.336E-2
 3 137
10 int:BLM BLM interactions 1.306E-4 9.955E-3
7.181E-2
9.955E-2
 3 140
11 int:NPC2 NPC2 interactions 1.602E-4 1.098E-2
7.921E-2
1.221E-1
 2 26
12 int:REV1 REV1 interactions 1.729E-4 1.098E-2
7.921E-2
1.318E-1
 2 27
13 int:TP53BP1 TP53BP1 interactions 2.011E-4 1.179E-2
8.504E-2
1.533E-1
 3 162
14 int:RPA1 RPA1 interactions 3.587E-4 1.845E-2
1.331E-1
2.733E-1
 4 497
15 int:CDC45 CDC45 interactions 3.633E-4 1.845E-2
1.331E-1
2.768E-1
 2 39
16 int:MT-ND1 MT-ND1 interactions 4.017E-4 1.913E-2
1.380E-1
3.061E-1
 2 41
17 int:IGHA1 IGHA1 interactions 5.059E-4 2.236E-2
1.613E-1
3.855E-1
 2 46
18 int:POLL POLL interactions 5.282E-4 2.236E-2
1.613E-1
4.025E-1
 2 47
19 int:INTS7 INTS7 interactions 8.602E-4 3.203E-2
2.310E-1
6.555E-1
 2 60
20 int:PPHLN1 PPHLN1 interactions 9.182E-4 3.203E-2
2.310E-1
6.997E-1
 2 62
21 int:WDR18 WDR18 interactions 9.182E-4 3.203E-2
2.310E-1
6.997E-1
 2 62
22 int:SRRM2 SRRM2 interactions 9.251E-4 3.203E-2
2.310E-1
7.049E-1
 3 273
23 int:XRCC5 XRCC5 interactions 9.750E-4 3.203E-2
2.310E-1
7.429E-1
 3 278
24 int:MYL12A MYL12A interactions 1.009E-3 3.203E-2
2.310E-1
7.687E-1
 2 65
25 int:PRKDC PRKDC interactions 1.135E-3 3.290E-2
2.374E-1
8.648E-1
 3 293
26 int:CSNK2B CSNK2B interactions 1.227E-3 3.290E-2
2.374E-1
9.346E-1
 3 301
27 int:SMC4 SMC4 interactions 1.236E-3 3.290E-2
2.374E-1
9.418E-1
 2 72
28 int:RFC2 RFC2 interactions 1.236E-3 3.290E-2
2.374E-1
9.418E-1
 2 72
29 int:TRIM26 TRIM26 interactions 1.340E-3 3.290E-2
2.374E-1
1.000E0
 2 75
30 int:PGGHG PGGHG interactions 1.468E-3 3.290E-2
2.374E-1
1.000E0
 1 2
31 int:BTBD16 BTBD16 interactions 1.468E-3 3.290E-2
2.374E-1
1.000E0
 1 2
32 int:BBOF1 BBOF1 interactions 1.468E-3 3.290E-2
2.374E-1
1.000E0
 1 2
33 int:AMZ2P1 AMZ2P1 interactions 1.468E-3 3.290E-2
2.374E-1
1.000E0
 1 2
34 int:CYB5R4 CYB5R4 interactions 1.468E-3 3.290E-2
2.374E-1
1.000E0
 1 2
35 int:ERH ERH interactions 1.638E-3 3.467E-2
2.501E-1
1.000E0
 2 83
36 int:KRR1 KRR1 interactions 1.638E-3 3.467E-2
2.501E-1
1.000E0
 2 83
37 int:FBXW7 FBXW7 interactions 1.697E-3 3.495E-2
2.521E-1
1.000E0
 3 337
38 int:SNX3 SNX3 interactions 1.757E-3 3.524E-2
2.542E-1
1.000E0
 2 86
39 int:UBE2H UBE2H interactions 2.095E-3 3.901E-2
2.814E-1
1.000E0
 2 94
40 int:AGAP4 AGAP4 interactions 2.202E-3 3.901E-2
2.814E-1
1.000E0
 1 3
41 int:FAM84A FAM84A interactions 2.202E-3 3.901E-2
2.814E-1
1.000E0
 1 3
42 int:GUSBP3 GUSBP3 interactions 2.202E-3 3.901E-2
2.814E-1
1.000E0
 1 3
43 int:WBP1L WBP1L interactions 2.202E-3 3.901E-2
2.814E-1
1.000E0
 1 3
44 int:MSH6 MSH6 interactions 2.604E-3 4.141E-2
2.987E-1
1.000E0
 2 105
45 int:RFC4 RFC4 interactions 2.703E-3 4.141E-2
2.987E-1
1.000E0
 2 107
46 int:STRAP STRAP interactions 2.753E-3 4.141E-2
2.987E-1
1.000E0
 2 108
47 int:PGBD3 PGBD3 interactions 2.934E-3 4.141E-2
2.987E-1
1.000E0
 1 4
48 int:C2orf42 C2orf42 interactions 2.934E-3 4.141E-2
2.987E-1
1.000E0
 1 4
49 int:FBLL1 FBLL1 interactions 2.934E-3 4.141E-2
2.987E-1
1.000E0
 1 4
50 int:CATSPERG CATSPERG interactions 2.934E-3 4.141E-2
2.987E-1
1.000E0
 1 4
Show 45 more annotations

10: Cytoband [Display Chart] 13 input genes in category / 13 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 13q33-q34 13q33-q34 3.751E-4 2.438E-3 7.753E-3 4.876E-3 1 1
2 4p14-p13 4p14-p13 3.751E-4 2.438E-3 7.753E-3 4.876E-3 1 1
3 2q11.1-q11.2 2q11.1-q11.2 7.500E-4 3.250E-3 1.034E-2 9.750E-3 1 2
4 10q23-q24 10q23-q24 3.371E-3 1.096E-2 3.484E-2 4.382E-2 1 9
5 10q23 10q23 4.866E-3 1.265E-2 4.023E-2
6.325E-2
 1 13
6 13q11 13q11 6.358E-3 1.378E-2 4.381E-2
8.266E-2
 1 17
7 7q36 7q36 1.008E-2 1.855E-2
5.898E-2
1.311E-1
 1 27
8 22q12.1 22q12.1 1.268E-2 1.855E-2
5.898E-2
1.648E-1
 1 34
9 18q23 18q23 1.305E-2 1.855E-2
5.898E-2
1.697E-1
 1 35
10 7p13 7p13 1.527E-2 1.855E-2
5.898E-2
1.985E-1
 1 41
11 3q22.1 3q22.1 1.638E-2 1.855E-2
5.898E-2
2.129E-1
 1 44
12 10p13 10p13 1.712E-2 1.855E-2
5.898E-2
2.225E-1
 1 46
13 12q24.31 12q24.31 2.996E-2 2.996E-2
9.529E-2
3.895E-1
 1 81
Show 8 more annotations

11: Transcription Factor Binding Site [Display Chart] 9 input genes in category / 67 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 10 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 535 DNA polymerases genenames.org 4.054E-10 2.838E-9 7.358E-9 2.838E-9 4 23
2 1247 Zinc fingers|Zinc fingers PARP-type|DNA ligases genenames.org 1.648E-3 5.126E-3 1.329E-2 1.154E-2 1 3
3 1335 Fanconi anemia complementation groups|DNA helicases|BRCA1 B complex genenames.org 2.197E-3 5.126E-3 1.329E-2 1.538E-2 1 4
4 1041 CTD family phosphatases genenames.org 4.389E-3 7.682E-3 1.992E-2 3.073E-2 1 8
5 684 Poly(ADP-ribose) polymerases genenames.org 9.307E-3 1.303E-2 3.378E-2
6.515E-2
 1 17
6 775 Myb/SANT domain containing|Trinucleotide repeat containing genenames.org 1.366E-2 1.594E-2 4.132E-2
9.562E-2
 1 25
7 413 AAA ATPases genenames.org 2.876E-2 2.876E-2
7.457E-2
2.013E-1
 1 53
Show 2 more annotations

13: Coexpression [Display Chart] 13 input genes in category / 1166 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9372 Genes involved in DNA replication, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.595E-15 3.026E-12 2.312E-11 3.026E-12 8 146
2 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.041E-13 6.068E-11 4.636E-10 1.214E-10 8 230
3 M1486 Putative targets or partners of EZH2 [GeneID=2146] in hematopoietic stem cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.459E-6 5.671E-4 4.332E-3 1.701E-3 3 41
4 M4495 Substrates of PRKDC [GeneID=5591]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.506E-5 1.334E-2
1.019E-1
6.420E-2
 2 20
5 M9516 Genes constituting the BRCA2-PCC network of transcripts whose expression positively correlated (Pearson correlation coefficient, PCC >= 0.4) with that of BRCA2 [GeneID=675] across a compendium of normal tissues. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.910E-5 1.334E-2
1.019E-1
8.057E-2
 4 423
6 19010929-TableS2 Human Breast Venables08 41genes GeneSigDB 1.432E-4 1.334E-2
1.019E-1
1.669E-1
 2 32
7 16715129-Table2 Human HeadandNeck Jarvinen06 40genes GeneSigDB 1.618E-4 1.334E-2
1.019E-1
1.887E-1
 2 34
8 M3487 Genes up-regulated in naive CD4 [GeneID=920] T cells from adult blood versus thymic stromal cells. MSigDB C7: Immunologic Signatures (v6.0) 1.657E-4 1.334E-2
1.019E-1
1.932E-1
 3 198
9 M7334 Genes down-regulated in HMC-1 (mast leukemia) cells: untreated versus stimulated with T cell membranes. MSigDB C7: Immunologic Signatures (v6.0) 1.682E-4 1.334E-2
1.019E-1
1.961E-1
 3 199
10 M7039 Genes up-regulated in megakaryo-erythrocyte progenitors: wildtype versus IKZF1 [GeneID=10320] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.334E-2
1.019E-1
1.991E-1
 3 200
11 M7148 Genes up-regulated in CD8A- [GeneID=925] splenic dendritic cells: wildtype versus IFNB1 [GeneID=3456] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.334E-2
1.019E-1
1.991E-1
 3 200
12 M9843 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4intermediate. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.334E-2
1.019E-1
1.991E-1
 3 200
13 M6198 Genes up-regulated in polymorphonuclear leukocytes (9h): treated by heat killed HC60 cell (promyelocytic leukemia) lysate versus A. phagocytophilum infection. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.334E-2
1.019E-1
1.991E-1
 3 200
14 M3788 Genes up-regulated in comparison of control dendritic cells (DC) at 8 h versus those stimulated with Gardiquimod (TLR7 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 1.707E-4 1.334E-2
1.019E-1
1.991E-1
 3 200
15 16293602-Table1 Mouse StemCell Kamminga06 56genes GeneSigDB 1.716E-4 1.334E-2
1.019E-1
2.001E-1
 2 35
16 M4988 Genes whose expression was increased due to copy number gain in laryngeal cancer tumors (both in primary cultures and cell lines). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.246E-4 1.637E-2
1.250E-1
2.619E-1
 2 40
17 16651409-SuppTable1 Mouse StemCell Lawlor06 285genes GeneSigDB 2.919E-4 2.002E-2
1.529E-1
3.404E-1
 3 240
18 20630075-AF-2 Mouse StemCell GarciaEscudero10 371genes p53 GeneSigDB 3.903E-4 2.528E-2
1.931E-1
4.550E-1
 3 265
19 M9575 DNA repair genes whose promoters contain putative ZNF143 [GeneID=7702] binding sites. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.733E-4 2.904E-2
2.219E-1
5.518E-1
 2 58
20 12925741-Figure9 Human Lymphoma Jenner03 92genes GeneSigDB 5.761E-4 3.359E-2
2.566E-1
6.717E-1
 2 64
21 15897889-Table4 Human Skin Kyng05 81genes GeneSigDB 8.762E-4 4.865E-2
3.717E-1
1.000E0
 2 79
Show 16 more annotations

14: Coexpression Atlas [Display Chart] 13 input genes in category / 345 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 9 input genes in category / 89 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 13 input genes in category / 298 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-4448:Functional MTI Functional MTI miRTarbase 8.908E-5 2.655E-2
1.666E-1
 2.655E-2 2 78

17: Drug [Display Chart] 13 input genes in category / 3116 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000446904 homobiotin Stitch 4.497E-10 1.401E-6 1.208E-5 1.401E-6 5 76
2 CID000000645 NSC82626 Stitch 2.817E-9 4.388E-6 3.783E-5 8.776E-6 5 109
3 CID000000621 NSC82625 Stitch 9.266E-9 9.624E-6 8.297E-5 2.887E-5 5 138
4 CID000000625 AC1Q6S3R Stitch 5.999E-8 4.586E-5 3.954E-4 1.869E-4 4 71
5 CID000003657 hydroxyurea Stitch 7.358E-8 4.586E-5 3.954E-4 2.293E-4 6 438
6 CID000001151 AC1Q6S3S Stitch 9.801E-7 5.090E-4 4.389E-3 3.054E-3 4 142
7 CID000092850 cholesteryl chloride Stitch 1.793E-6 7.982E-4 6.881E-3 5.587E-3 2 4
8 CID000441040 AC1L9AG5 Stitch 2.987E-6 1.034E-3 8.917E-3 9.309E-3 2 5
9 CID002735127 Q-Dt Stitch 2.987E-6 1.034E-3 8.917E-3 9.309E-3 2 5
10 CID000001139 NSC46713 Stitch 4.479E-6 1.396E-3 1.203E-2 1.396E-2 4 208
11 CID000105003 Kalzinol Stitch 8.050E-6 2.280E-3 1.966E-2 2.508E-2 3 71
12 CID000002210 NSC351140 Stitch 1.050E-5 2.725E-3 2.350E-2 3.270E-2 4 258
13 CID000065051 ddTTP Stitch 1.434E-5 3.438E-3 2.964E-2 4.469E-2 3 86
14 CID000004156 methyl methanesulfonate Stitch 4.048E-5 9.010E-3
7.769E-2
1.261E-1
 4 364
15 CID000000624 ST013873 Stitch 4.829E-5 9.624E-3
8.298E-2
1.505E-1
 3 129
16 CID002723601 6-thioguanine Stitch 4.942E-5 9.624E-3
8.298E-2
1.540E-1
 3 130
17 CID006438404 BVdUTP Stitch 6.863E-5 1.188E-2
1.024E-1
2.139E-1
 2 22
18 CID006438779 petasiphenol Stitch 6.863E-5 1.188E-2
1.024E-1
2.139E-1
 2 22
19 CID000105116 1,N6-ethenodeoxyadenosine Stitch 8.905E-5 1.460E-2
1.259E-1
2.775E-1
 2 25
20 CID005289542 UV-C Stitch 9.682E-5 1.508E-2
1.301E-1
3.017E-1
 3 163
21 CID000072188 araTTP Stitch 1.041E-4 1.545E-2
1.332E-1
3.244E-1
 2 27
22 CID000005192 sebacate Stitch 1.320E-4 1.870E-2
1.612E-1
4.114E-1
 3 181
23 ctd:C408982 CPG-oligonucleotide CTD 1.386E-4 1.878E-2
1.619E-1
4.319E-1
 3 184
24 CID000439200 AC1L96VB Stitch 1.548E-4 1.962E-2
1.691E-1
4.823E-1
 3 191
25 7173 UP Ungerine nitrate; Up 200; 10.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.670E-4 1.962E-2
1.691E-1
5.205E-1
 3 196
26 7149 DN Aconitine [302-27-2]; Down 200; 6.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.696E-4 1.962E-2
1.691E-1
5.284E-1
 3 197
27 2653 DN Estradiol-17 beta [50-28-2]; Down 200; 14.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.721E-4 1.962E-2
1.691E-1
5.363E-1
 3 198
28 6152 DN Piperacetazine [3819-00-9]; Down 200; 9.8uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.773E-4 1.962E-2
1.691E-1
5.524E-1
 3 200
29 CID000449124 Argifin Stitch 1.826E-4 1.962E-2
1.691E-1
5.689E-1
 3 202
30 CID000448110 bp G Stitch 2.190E-4 2.274E-2
1.961E-1
6.823E-1
 2 39
31 CID000000593 NSC20261 Stitch 2.475E-4 2.488E-2
2.145E-1
7.713E-1
 3 224
32 CID000041322 anti-BaPDE Stitch 2.814E-4 2.740E-2
2.363E-1
8.769E-1
 3 234
33 CID000018058 thymine glycol Stitch 3.607E-4 2.956E-2
2.548E-1
1.000E0
 2 50
34 CID000001460 AC1L1BJ2 Stitch 3.753E-4 2.956E-2
2.548E-1
1.000E0
 2 51
35 CID000137438 AC1L3ALC Stitch 3.902E-4 2.956E-2
2.548E-1
1.000E0
 2 52
36 CID000005897 2-acetylaminofluorene Stitch 3.919E-4 2.956E-2
2.548E-1
1.000E0
 3 262
37 CID000115150 ICRF-193 Stitch 4.208E-4 2.956E-2
2.548E-1
1.000E0
 2 54
38 CID000002353 berberine Stitch 4.759E-4 2.956E-2
2.548E-1
1.000E0
 3 280
39 CID000123282 C-2-Y Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
40 CID000099774 dapmavarone Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
41 CID000073379 streptoval C Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
42 CID000140835 heptasulfur Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
43 CID000196333 poly(2-amino-8-methyladenylic acid Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
44 CID000026696 Fcpa Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
45 CID000640752 hexaethynylbenzene Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
46 CID000138399 phenylsulfanyl Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
47 CID000042764 meobentine Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
48 CID000101908 methylaluminum dichloride Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
49 CID003013895 11-hydroxyhexadecanoic acid Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
50 CID000637173 cephalotaxine alpha-N-oxide Stitch 5.692E-4 2.956E-2
2.548E-1
1.000E0
 1 1
Show 45 more annotations

18: Disease [Display Chart] 13 input genes in category / 311 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 OMIN:602450 SEVERE COMBINED IMMUNODEFICIENCY WITH SENSITIVITY TO IONIZING RADIATION OMIM 5.941E-7 1.848E-4 1.167E-3 1.848E-4 2 2
2 C0206019 HIV Encephalopathy DisGeNET BeFree 2.062E-4 1.649E-2
1.042E-1
6.412E-2
 2 27
3 C2700553 Omenn Syndrome DisGeNET Curated 2.062E-4 1.649E-2
1.042E-1
6.412E-2
 2 27
4 C0276548 HIV encephalitis DisGeNET BeFree 2.383E-4 1.649E-2
1.042E-1
7.410E-2
 2 29
5 C0494261 Combined immunodeficiency DisGeNET Curated 2.907E-4 1.649E-2
1.042E-1
9.041E-2
 2 32
6 C1292769 Precursor B-cell lymphoblastic leukemia DisGeNET BeFree 3.182E-4 1.649E-2
1.042E-1
9.897E-2
 4 441
7 cv:C1847827 Lig4 syndrome Clinical Variations 8.022E-4 2.079E-2
1.314E-1
2.495E-1
 1 1
8 C1858726 Congenital Cataracts, Facial Dysmorphism, And Neuropathy DisGeNET Curated 8.022E-4 2.079E-2
1.314E-1
2.495E-1
 1 1
9 cv:C1865370 Severe combined immunodeficiency with sensitivity to ionizing radiation Clinical Variations 8.022E-4 2.079E-2
1.314E-1
2.495E-1
 1 1
10 OMIN:606593 LIG4 SYNDROME OMIM 8.022E-4 2.079E-2
1.314E-1
2.495E-1
 1 1
11 OMIN:604168 CONGENITAL CATARACTS, FACIAL DYSMORPHISM, AND NEUROPATHY OMIM 8.022E-4 2.079E-2
1.314E-1
2.495E-1
 1 1
12 cv:C1858726 Congenital Cataracts, Facial Dysmorphism, and Neuropathy Clinical Variations 8.022E-4 2.079E-2
1.314E-1
2.495E-1
 1 1
13 C3807306 Rhabdomyolysis, acute DisGeNET Curated 1.604E-3 2.771E-2
1.751E-1
4.988E-1
 1 2
14 C1865370 Severe combined immunodeficiency with sensitivity to ionizing radiation DisGeNET Curated 1.604E-3 2.771E-2
1.751E-1
4.988E-1
 1 2
15 C0175691 Dubowitz syndrome DisGeNET Curated 1.604E-3 2.771E-2
1.751E-1
4.988E-1
 1 2
16 C1969799 Severe Combined Immunodeficiency with Microcephaly, Growth Retardation, and Sensitivity to Ionizing Radiation DisGeNET Curated 1.604E-3 2.771E-2
1.751E-1
4.988E-1
 1 2
17 cv:C0026764 Multiple myeloma Clinical Variations 1.604E-3 2.771E-2
1.751E-1
4.988E-1
 1 2
18 C1847827 LIG4 Syndrome DisGeNET Curated 1.604E-3 2.771E-2
1.751E-1
4.988E-1
 1 2
19 OMIN:254500 MYELOMA, MULTIPLE OMIM 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
20 OMIN:603554 OMENN SYNDROME OMIM 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
21 C2749625 Motor axonal neuropathy DisGeNET Curated 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
22 C4020811 Length dependent motor neuropathy DisGeNET Curated 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
23 cv:C1801959 Histiocytic medullary reticulosis Clinical Variations 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
24 C1854570 Distal motor neuropathy DisGeNET Curated 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
25 C1849236 Severe combined immunodeficiency, atypical DisGeNET BeFree 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
26 C2931884 Reticuloendotheliosis, familial, with eosinophilia DisGeNET Curated 2.405E-3 2.877E-2
1.818E-1
7.479E-1
 1 3
27 C0023485 Precursor B-Cell Lymphoblastic Leukemia-Lymphoma DisGeNET Curated 2.813E-3 3.021E-2
1.909E-1
8.749E-1
 2 100
28 C1837758 Bird-like facies DisGeNET Curated 3.205E-3 3.021E-2
1.909E-1
9.969E-1
 1 4
29 C1858732 Prominent midface DisGeNET Curated 3.205E-3 3.021E-2
1.909E-1
9.969E-1
 1 4
30 C4025830 Peripheral axonal degeneration DisGeNET Curated 3.205E-3 3.021E-2
1.909E-1
9.969E-1
 1 4
31 C1865371 SEVERE COMBINED IMMUNODEFICIENCY, ATHABASKAN-TYPE DisGeNET Curated 3.205E-3 3.021E-2
1.909E-1
9.969E-1
 1 4
32 C4020690 Abnormality of peripheral nerve conduction DisGeNET Curated 3.205E-3 3.021E-2
1.909E-1
9.969E-1
 1 4
33 C4280374 Hyperplasia of malar bones DisGeNET Curated 3.205E-3 3.021E-2
1.909E-1
9.969E-1
 1 4
34 C4025579 Large beaked nose DisGeNET Curated 4.005E-3 3.664E-2
2.315E-1
1.000E0
 1 5
35 C1852464 Cervical vertebral abnormalities DisGeNET Curated 4.804E-3 4.150E-2
2.623E-1
1.000E0
 1 6
36 C4280572 Acute blood cancer DisGeNET Curated 4.804E-3 4.150E-2
2.623E-1
1.000E0
 1 6
37 C4024927 Peripheral hypomyelination DisGeNET Curated 5.603E-3 4.710E-2
2.976E-1
1.000E0
 1 7
38 C0025958 Microcephaly DisGeNET Curated 6.371E-3 4.977E-2
3.145E-1
1.000E0
 2 152
39 C0302362 Brucella melitensis infection DisGeNET BeFree 6.401E-3 4.977E-2
3.145E-1
1.000E0
 1 8
40 C4021822 Abnormality of female external genitalia DisGeNET Curated 6.401E-3 4.977E-2
3.145E-1
1.000E0
 1 8
Show 35 more annotations