Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc153_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 51 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008481 sphinganine kinase activity 5.358E-4 1.025E-2 4.630E-2 2.733E-2 1 2
2 GO:0017050 D-erythro-sphingosine kinase activity 5.358E-4 1.025E-2 4.630E-2 2.733E-2 1 2
3 GO:0004605 phosphatidate cytidylyltransferase activity 8.036E-4 1.025E-2 4.630E-2 4.099E-2 1 3
4 GO:0004142 diacylglycerol cholinephosphotransferase activity 8.036E-4 1.025E-2 4.630E-2 4.099E-2 1 3
5 GO:0005516 calmodulin binding 1.011E-3 1.031E-2 4.658E-2
5.154E-2
 2 190
6 GO:0001727 lipid kinase activity 1.607E-3 1.366E-2
6.172E-2
8.195E-2
 1 6
7 GO:0038036 sphingosine-1-phosphate receptor activity 2.142E-3 1.536E-2
6.941E-2
1.092E-1
 1 8
8 GO:0017169 CDP-alcohol phosphatidyltransferase activity 2.409E-3 1.536E-2
6.941E-2
1.229E-1
 1 9
9 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity 3.211E-3 1.706E-2
7.707E-2
1.638E-1
 1 12
10 GO:0045125 bioactive lipid receptor activity 3.746E-3 1.706E-2
7.707E-2
1.910E-1
 1 14
11 GO:0005159 insulin-like growth factor receptor binding 4.013E-3 1.706E-2
7.707E-2
2.047E-1
 1 15
12 GO:0070567 cytidylyltransferase activity 4.013E-3 1.706E-2
7.707E-2
2.047E-1
 1 15
13 GO:0005521 lamin binding 4.547E-3 1.784E-2
8.061E-2
2.319E-1
 1 17
14 GO:0016780 phosphotransferase activity, for other substituted phosphate groups 5.615E-3 2.045E-2
9.243E-2
2.863E-1
 1 21
15 GO:0004697 protein kinase C activity 6.415E-3 2.181E-2
9.856E-2
3.271E-1
 1 24
16 GO:0004435 phosphatidylinositol phospholipase C activity 7.481E-3 2.384E-2
1.077E-1
3.815E-1
 1 28
17 GO:0042169 SH2 domain binding 9.078E-3 2.463E-2
1.113E-1
4.630E-1
 1 34
18 GO:0005158 insulin receptor binding 9.078E-3 2.463E-2
1.113E-1
4.630E-1
 1 34
19 GO:0051721 protein phosphatase 2A binding 9.344E-3 2.463E-2
1.113E-1
4.765E-1
 1 35
20 GO:0004629 phospholipase C activity 9.876E-3 2.463E-2
1.113E-1
5.037E-1
 1 37
21 GO:0043548 phosphatidylinositol 3-kinase binding 1.014E-2 2.463E-2
1.113E-1
5.172E-1
 1 38
22 GO:0016303 1-phosphatidylinositol-3-kinase activity 1.147E-2 2.659E-2
1.201E-1
5.849E-1
 1 43
23 GO:0052742 phosphatidylinositol kinase activity 1.545E-2 3.117E-2
1.409E-1
7.877E-1
 1 58
24 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding 1.571E-2 3.117E-2
1.409E-1
8.012E-1
 1 59
25 GO:0030971 receptor tyrosine kinase binding 1.597E-2 3.117E-2
1.409E-1
8.147E-1
 1 60
26 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 1.650E-2 3.117E-2
1.409E-1
8.417E-1
 1 62
27 GO:0005080 protein kinase C binding 1.650E-2 3.117E-2
1.409E-1
8.417E-1
 1 62
28 GO:1990782 protein tyrosine kinase binding 1.756E-2 3.199E-2
1.445E-1
8.956E-1
 1 66
29 GO:0052813 phosphatidylinositol bisphosphate kinase activity 1.915E-2 3.367E-2
1.521E-1
9.764E-1
 1 72
30 GO:0035004 phosphatidylinositol 3-kinase activity 2.046E-2 3.410E-2
1.541E-1
1.000E0
 1 77
31 GO:0035591 signaling adaptor activity 2.073E-2 3.410E-2
1.541E-1
1.000E0
 1 78
32 GO:1902936 phosphatidylinositol bisphosphate binding 2.178E-2 3.471E-2
1.569E-1
1.000E0
 1 82
33 GO:0008081 phosphoric diester hydrolase activity 2.599E-2 4.016E-2
1.815E-1
1.000E0
 1 98
34 GO:0004620 phospholipase activity 3.279E-2 4.918E-2
2.223E-1
1.000E0
 1 124
35 GO:1901981 phosphatidylinositol phosphate binding 3.383E-2 4.930E-2
2.228E-1
1.000E0
 1 128
36 GO:0016779 nucleotidyltransferase activity 3.487E-2 4.941E-2
2.233E-1
1.000E0
 1 132
Show 31 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 649 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1903532 positive regulation of secretion by cell 1.217E-6 5.355E-4 3.777E-3 7.901E-4 4 417
2 GO:0051047 positive regulation of secretion 1.650E-6 5.355E-4 3.777E-3 1.071E-3 4 450
3 GO:0008286 insulin receptor signaling pathway 2.994E-6 6.478E-4 4.569E-3 1.943E-3 3 126
4 GO:0046488 phosphatidylinositol metabolic process 1.237E-5 1.753E-3 1.237E-2 8.031E-3 3 202
5 GO:0032869 cellular response to insulin stimulus 1.351E-5 1.753E-3 1.237E-2 8.767E-3 3 208
6 GO:0032868 response to insulin 2.821E-5 2.504E-3 1.766E-2 1.831E-2 3 266
7 GO:0090087 regulation of peptide transport 3.614E-5 2.504E-3 1.766E-2 2.346E-2 3 289
8 GO:0046627 negative regulation of insulin receptor signaling pathway 3.620E-5 2.504E-3 1.766E-2 2.349E-2 2 36
9 GO:0016042 lipid catabolic process 4.163E-5 2.504E-3 1.766E-2 2.702E-2 3 303
10 GO:0048009 insulin-like growth factor receptor signaling pathway 4.256E-5 2.504E-3 1.766E-2 2.762E-2 2 39
11 GO:1900077 negative regulation of cellular response to insulin stimulus 4.256E-5 2.504E-3 1.766E-2 2.762E-2 2 39
12 GO:0006650 glycerophospholipid metabolic process 4.630E-5 2.504E-3 1.766E-2 3.005E-2 3 314
13 GO:0071375 cellular response to peptide hormone stimulus 5.084E-5 2.538E-3 1.790E-2 3.300E-2 3 324
14 GO:1901653 cellular response to peptide 5.870E-5 2.721E-3 1.919E-2 3.810E-2 3 340
15 GO:0015833 peptide transport 6.789E-5 2.937E-3 2.072E-2 4.406E-2 3 357
16 GO:0046626 regulation of insulin receptor signaling pathway 7.606E-5 3.085E-3 2.176E-2 4.936E-2 2 52
17 GO:0042886 amide transport 8.435E-5 3.209E-3 2.264E-2
5.474E-2
 3 384
18 GO:0034504 protein localization to nucleus 8.901E-5 3.209E-3 2.264E-2
5.777E-2
 3 391
19 GO:0046486 glycerolipid metabolic process 1.003E-4 3.278E-3 2.312E-2
6.509E-2
 3 407
20 GO:0006066 alcohol metabolic process 1.010E-4 3.278E-3 2.312E-2
6.556E-2
 3 408
21 GO:0006644 phospholipid metabolic process 1.141E-4 3.525E-3 2.486E-2
7.402E-2
 3 425
22 GO:0043434 response to peptide hormone 1.282E-4 3.781E-3 2.667E-2
8.317E-2
 3 442
23 GO:1900076 regulation of cellular response to insulin stimulus 1.423E-4 4.014E-3 2.831E-2
9.232E-2
 2 71
24 GO:1901652 response to peptide 1.607E-4 4.346E-3 3.065E-2
1.043E-1
 3 477
25 GO:2000438 negative regulation of monocyte extravasation 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
26 GO:0035724 CD24 biosynthetic process 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
27 GO:0090275 negative regulation of somatostatin secretion 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
28 GO:0071350 cellular response to interleukin-15 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
29 GO:2000559 regulation of CD24 biosynthetic process 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
30 GO:2000560 positive regulation of CD24 biosynthetic process 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
31 GO:0046521 sphingoid catabolic process 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
32 GO:0035723 interleukin-15-mediated signaling pathway 2.685E-4 5.445E-3 3.840E-2
1.742E-1
 1 1
33 GO:0046834 lipid phosphorylation 2.769E-4 5.445E-3 3.840E-2
1.797E-1
 2 99
34 GO:0042307 positive regulation of protein import into nucleus 3.174E-4 6.058E-3 4.273E-2
2.060E-1
 2 106
35 GO:1904591 positive regulation of protein import 3.356E-4 6.222E-3 4.389E-2
2.178E-1
 2 109
36 GO:0019751 polyol metabolic process 3.480E-4 6.273E-3 4.425E-2
2.258E-1
 2 111
37 GO:0031503 protein-containing complex localization 3.998E-4 7.013E-3 4.947E-2
2.595E-1
 2 119
38 GO:0070555 response to interleukin-1 4.341E-4 7.413E-3
5.229E-2
2.817E-1
 2 124
39 GO:0006661 phosphatidylinositol biosynthetic process 4.553E-4 7.503E-3
5.292E-2
2.955E-1
 2 127
40 GO:0046824 positive regulation of nucleocytoplasmic transport 4.624E-4 7.503E-3
5.292E-2
3.001E-1
 2 128
41 GO:0045931 positive regulation of mitotic cell cycle 4.917E-4 7.580E-3
5.346E-2
3.191E-1
 2 132
42 GO:0035712 T-helper 2 cell activation 5.369E-4 7.580E-3
5.346E-2
3.485E-1
 1 2
43 GO:2000570 positive regulation of T-helper 2 cell activation 5.369E-4 7.580E-3
5.346E-2
3.485E-1
 1 2
44 GO:0060466 activation of meiosis involved in egg activation 5.369E-4 7.580E-3
5.346E-2
3.485E-1
 1 2
45 GO:2000569 regulation of T-helper 2 cell activation 5.369E-4 7.580E-3
5.346E-2
3.485E-1
 1 2
46 GO:1900182 positive regulation of protein localization to nucleus 5.372E-4 7.580E-3
5.346E-2
3.487E-1
 2 138
47 GO:0051092 positive regulation of NF-kappaB transcription factor activity 5.529E-4 7.634E-3
5.385E-2
3.588E-1
 2 140
48 GO:0046165 alcohol biosynthetic process 7.123E-4 9.630E-3
6.793E-2
4.623E-1
 2 159
49 GO:0070094 positive regulation of glucagon secretion 8.053E-4 1.005E-2
7.089E-2
5.226E-1
 1 3
50 GO:0035722 interleukin-12-mediated signaling pathway 8.053E-4 1.005E-2
7.089E-2
5.226E-1
 1 3
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005899 insulin receptor complex 7.868E-4 1.967E-2
7.506E-2
 1.967E-2 1 3

4: Human Phenotype [Display Chart] 2 input genes in category / 16 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 4 input genes in category / 379 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 5 input genes in category / 65 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR028400 PLC-beta1 InterPro 2.669E-4 4.336E-3 2.064E-2 1.735E-2 1 1
2 IPR027264 PKC theta InterPro 2.669E-4 4.336E-3 2.064E-2 1.735E-2 1 1
3 IPR016720 PC Trfase euk InterPro 5.337E-4 4.336E-3 2.064E-2 3.469E-2 1 2
4 PS01315 CDS PROSITE 5.337E-4 4.336E-3 2.064E-2 3.469E-2 1 2
5 IPR000374 PC trans InterPro 5.337E-4 4.336E-3 2.064E-2 3.469E-2 1 2
6 PS50004 C2 PROSITE 5.620E-4 4.336E-3 2.064E-2 3.653E-2 2 142
7 2.60.40.150 - Gene3D 6.103E-4 4.336E-3 2.064E-2 3.967E-2 2 148
8 IPR000008 C2 dom InterPro 7.485E-4 4.336E-3 2.064E-2 4.866E-2 2 164
9 PF06631 DUF1154 Pfam 8.005E-4 4.336E-3 2.064E-2
5.203E-2
 1 3
10 IPR009535 PLC-beta CS InterPro 8.005E-4 4.336E-3 2.064E-2
5.203E-2
 1 3
11 IPR014815 PLC-beta C InterPro 8.005E-4 4.336E-3 2.064E-2
5.203E-2
 1 3
12 PF08703 PLC-beta C Pfam 8.005E-4 4.336E-3 2.064E-2
5.203E-2
 1 3
13 IPR014376 Prot kin PKC delta InterPro 1.067E-3 4.955E-3 2.358E-2
6.937E-2
 1 4
14 IPR016280 PLC-beta InterPro 1.067E-3 4.955E-3 2.358E-2
6.937E-2
 1 4
15 SM00310 PTBI SMART 2.933E-3 8.959E-3 4.264E-2
1.906E-1
 1 11
16 PS51064 IRS PTB PROSITE 3.199E-3 8.959E-3 4.264E-2
2.079E-1
 1 12
17 PF02174 IRS Pfam 3.731E-3 8.959E-3 4.264E-2
2.425E-1
 1 14
18 IPR002404 IRS PTB InterPro 3.731E-3 8.959E-3 4.264E-2
2.425E-1
 1 14
19 SM00046 DAGKc SMART 3.731E-3 8.959E-3 4.264E-2
2.425E-1
 1 14
20 PS50146 DAGK PROSITE 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
21 PF00781 DAGK cat Pfam 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
22 SM00149 PLCYc SMART 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
23 PF09279 EF-hand like Pfam 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
24 PF00387 PI-PLC-Y Pfam 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
25 IPR015359 PLC EF-hand-like InterPro 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
26 PS50008 PIPLC Y DOMAIN PROSITE 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
27 IPR001206 Diacylglycerol kinase cat dom InterPro 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
28 IPR001192 PI-PLC fam InterPro 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
29 IPR001711 PLipase C Pinositol-sp Y InterPro 3.997E-3 8.959E-3 4.264E-2
2.598E-1
 1 15
30 IPR016064 NAD/diacylglycerol kinase InterPro 4.529E-3 9.399E-3 4.473E-2
2.944E-1
 1 17
31 SM00148 PLCXc SMART 4.795E-3 9.399E-3 4.473E-2
3.117E-1
 1 18
32 PF00388 PI-PLC-X Pfam 4.795E-3 9.399E-3 4.473E-2
3.117E-1
 1 18
33 IPR011993 PH dom-like InterPro 4.951E-3 9.399E-3 4.473E-2
3.218E-1
 2 427
34 PS50007 PIPLC X DOMAIN PROSITE 5.061E-3 9.399E-3 4.473E-2
3.290E-1
 1 19
35 IPR000909 PLipase C PInositol-sp X dom InterPro 5.061E-3 9.399E-3 4.473E-2
3.290E-1
 1 19
36 IPR020454 DAG/PE-bd InterPro 5.593E-3 1.010E-2 4.806E-2
3.635E-1
 1 21
37 IPR017946 PLC-like Pdiesterase TIM-brl InterPro 6.655E-3 1.138E-2
5.418E-2
4.326E-1
 1 25
38 3.20.20.190 - Gene3D 6.655E-3 1.138E-2
5.418E-2
4.326E-1
 1 25
39 IPR017892 Pkinase C InterPro 9.837E-3 1.639E-2
7.803E-2
6.394E-1
 1 37
40 PF00433 Pkinase C Pfam 1.116E-2 1.814E-2
8.631E-2
7.254E-1
 1 42
41 SM00133 S TK X SMART 1.486E-2 2.234E-2
1.063E-1
9.658E-1
 1 56
42 PS51285 AGC KINASE CTER PROSITE 1.486E-2 2.234E-2
1.063E-1
9.658E-1
 1 56
43 IPR000961 AGC-kinase C InterPro 1.486E-2 2.234E-2
1.063E-1
9.658E-1
 1 56
44 PF00130 C1 1 Pfam 1.512E-2 2.234E-2
1.063E-1
9.829E-1
 1 57
45 PS00479 ZF DAG PE 1 PROSITE 1.697E-2 2.369E-2
1.127E-1
1.000E0
 1 64
46 PS50081 ZF DAG PE 2 PROSITE 1.697E-2 2.369E-2
1.127E-1
1.000E0
 1 64
47 SM00109 C1 SMART 1.723E-2 2.369E-2
1.127E-1
1.000E0
 1 65
48 IPR002219 PE/DAG-bd InterPro 1.749E-2 2.369E-2
1.127E-1
1.000E0
 1 66
49 PF00168 C2 Pfam 3.448E-2 4.574E-2
2.177E-1
1.000E0
 1 131
50 SM00239 C2 SMART 3.604E-2 4.685E-2
2.230E-1
1.000E0
 1 137
Show 45 more annotations

7: Pathway [Display Chart] 5 input genes in category / 251 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M10579 Phospholipids as signalling intermediaries MSigDB C2 BIOCARTA (v6.0) 4.511E-5 5.662E-3 3.456E-2 1.132E-2 2 27
2 PW:0000143 insulin signaling Pathway Ontology 4.511E-5 5.662E-3 3.456E-2 1.132E-2 2 27
3 P04385 Histamine H1 receptor mediated signaling pathway PantherDB 1.104E-4 7.580E-3 4.627E-2 2.771E-2 2 42
4 137958 Endothelins BioSystems: Pathway Interaction Database 1.764E-4 7.580E-3 4.627E-2 4.427E-2 2 53
5 P04391 Oxytocin receptor mediated signaling pathway PantherDB 1.900E-4 7.580E-3 4.627E-2 4.769E-2 2 55
6 P00056 VEGF signaling pathway PantherDB 2.114E-4 7.580E-3 4.627E-2
5.306E-2
 2 58
7 P04394 Thyrotropin-releasing hormone receptor signaling pathway PantherDB 2.114E-4 7.580E-3 4.627E-2
5.306E-2
 2 58
8 P04374 5HT2 type receptor mediated signaling pathway PantherDB 2.496E-4 7.830E-3 4.780E-2
6.264E-2
 2 63
9 83093 Adipocytokine signaling pathway BioSystems: KEGG 2.995E-4 8.352E-3
5.099E-2
7.517E-2
 2 69
10 P00019 Endothelin signaling pathway PantherDB 3.353E-4 8.415E-3
5.137E-2
8.415E-2
 2 73
11 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 4.327E-4 9.874E-3
6.028E-2
1.086E-1
 3 446
12 948277 Inflammatory mediator regulation of TRP channels BioSystems: KEGG 5.917E-4 1.142E-2
6.974E-2
1.485E-1
 2 97
13 83052 Phosphatidylinositol signaling system BioSystems: KEGG 5.917E-4 1.142E-2
6.974E-2
1.485E-1
 2 97
14 1272486 Insulin resistance BioSystems: KEGG 7.195E-4 1.260E-2
7.691E-2
1.806E-1
 2 107
15 P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PantherDB 7.741E-4 1.260E-2
7.691E-2
1.943E-1
 2 111
16 PW:0000046 inositol metabolic Pathway Ontology 8.031E-4 1.260E-2
7.691E-2
2.016E-1
 1 2
17 1144995 Sphingolipid signaling pathway BioSystems: KEGG 8.743E-4 1.282E-2
7.824E-2
2.194E-1
 2 118
18 96530 Vascular smooth muscle contraction BioSystems: KEGG 9.190E-4 1.282E-2
7.824E-2
2.307E-1
 2 121
19 83058 Autophagy - animal BioSystems: KEGG 1.028E-3 1.358E-2
8.289E-2
2.580E-1
 2 128
20 1492886 Apelin signaling pathway BioSystems: KEGG 1.193E-3 1.440E-2
8.788E-2
2.995E-1
 2 138
21 413389 Sphingosine degradation BioSystems: KEGG 1.204E-3 1.440E-2
8.788E-2
3.023E-1
 1 3
22 1311074 Phospholipase D signaling pathway BioSystems: KEGG 1.335E-3 1.523E-2
9.295E-2
3.350E-1
 2 146
23 P00005 Angiogenesis PantherDB 1.408E-3 1.537E-2
9.380E-2
3.534E-1
 2 150
24 983748 cGMP-PKG signaling pathway BioSystems: KEGG 1.660E-3 1.736E-2
1.060E-1
4.167E-1
 2 163
25 1270066 Synthesis of PI BioSystems: REACTOME 2.007E-3 1.919E-2
1.172E-1
5.037E-1
 1 5
26 1269430 IRS activation BioSystems: REACTOME 2.007E-3 1.919E-2
1.172E-1
5.037E-1
 1 5
27 83050 Calcium signaling pathway BioSystems: KEGG 2.065E-3 1.919E-2
1.172E-1
5.182E-1
 2 182
28 1269578 G alpha (q) signalling events BioSystems: REACTOME 2.295E-3 2.057E-2
1.256E-1
5.760E-1
 2 192
29 P05726 2-arachidonoylglycerol biosynthesis PantherDB 2.408E-3 2.084E-2
1.272E-1
6.043E-1
 1 6
30 1270106 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion BioSystems: REACTOME 3.209E-3 2.598E-2
1.586E-1
8.055E-1
 1 8
31 1270105 Free fatty acids regulate insulin secretion BioSystems: REACTOME 3.209E-3 2.598E-2
1.586E-1
8.055E-1
 1 8
32 545351 sphingosine and sphingosine-1-phosphate metabolism BioSystems: BIOCYC 3.610E-3 2.831E-2
1.729E-1
9.061E-1
 1 9
33 1270104 Acetylcholine regulates insulin secretion BioSystems: REACTOME 4.010E-3 2.876E-2
1.756E-1
1.000E0
 1 10
34 M7772 fl-arrestins in GPCR Desensitization MSigDB C2 BIOCARTA (v6.0) 4.010E-3 2.876E-2
1.756E-1
1.000E0
 1 10
35 1269441 Signal attenuation BioSystems: REACTOME 4.010E-3 2.876E-2
1.756E-1
1.000E0
 1 10
36 1269485 VEGFR2 mediated cell proliferation BioSystems: REACTOME 4.199E-3 2.928E-2
1.787E-1
1.000E0
 2 261
37 M5415 IL 4 signaling pathway MSigDB C2 BIOCARTA (v6.0) 4.411E-3 2.992E-2
1.827E-1
1.000E0
 1 11
38 M668 Role of fl-arrestins in the activation and targeting of MAP kinases MSigDB C2 BIOCARTA (v6.0) 4.811E-3 3.019E-2
1.843E-1
1.000E0
 1 12
39 PW:0000363 leptin system Pathway Ontology 4.811E-3 3.019E-2
1.843E-1
1.000E0
 1 12
40 PW:0000238 insulin-like growth factor signaling Pathway Ontology 4.811E-3 3.019E-2
1.843E-1
1.000E0
 1 12
41 PW:0000064 propanoate metabolic Pathway Ontology 5.211E-3 3.190E-2
1.947E-1
1.000E0
 1 13
42 P00057 Wnt signaling pathway PantherDB 5.696E-3 3.404E-2
2.078E-1
1.000E0
 2 305
43 M111 Roles of fl-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling MSigDB C2 BIOCARTA (v6.0) 6.011E-3 3.508E-2
2.142E-1
1.000E0
 1 15
44 M4388 Cadmium induces DNA synthesis and proliferation in macrophages MSigDB C2 BIOCARTA (v6.0) 6.410E-3 3.637E-2
2.220E-1
1.000E0
 1 16
45 1269483 VEGFA-VEGFR2 Pathway BioSystems: REACTOME 6.761E-3 3.637E-2
2.220E-1
1.000E0
 2 333
46 M16626 Regulation of ck1/cdk5 by type 1 glutamate receptors MSigDB C2 BIOCARTA (v6.0) 6.810E-3 3.637E-2
2.220E-1
1.000E0
 1 17
47 PW:0000071 valine, leucine and isoleucine degradation Pathway Ontology 6.810E-3 3.637E-2
2.220E-1
1.000E0
 1 17
48 1269480 Signaling by VEGF BioSystems: REACTOME 7.081E-3 3.684E-2
2.249E-1
1.000E0
 2 341
49 142255 CDP-diacylglycerol biosynthesis BioSystems: BIOCYC 7.608E-3 3.684E-2
2.249E-1
1.000E0
 1 19
50 1269582 G beta:gamma signalling through PLC beta BioSystems: REACTOME 8.008E-3 3.684E-2
2.249E-1
1.000E0
 1 20
Show 45 more annotations

8: Pubmed [Display Chart] 5 input genes in category / 1778 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15364919 Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101). Pubmed 8.226E-8 7.313E-5 5.895E-4 1.463E-4 2 4
2 24053798 Suppression of protein kinase C theta contributes to enhanced myogenesis in vitro via IRS1 and ERK1/2 phosphorylation. Pubmed 8.226E-8 7.313E-5 5.895E-4 1.463E-4 2 4
3 10843712 Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. Pubmed 4.108E-6 4.006E-4 3.229E-3 7.305E-3 2 25
4 20336759 Mechanism of HIV-1-TAT induction of interleukin-1beta from human monocytes: Involvement of the phospholipase C/protein kinase C signaling cascade. Pubmed 4.806E-6 4.006E-4 3.229E-3 8.546E-3 2 27
5 12482669 Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. Pubmed 1.014E-5 4.006E-4 3.229E-3 1.803E-2 2 39
6 14968112 Identification of NPM-ALK interacting proteins by tandem mass spectrometry. Pubmed 1.479E-5 4.006E-4 3.229E-3 2.629E-2 2 47
7 16129690 Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
8 25977289 An increased expression of PI-PLCβ1 is associated with myeloid differentiation and a longer response to azacitidine in myelodysplastic syndromes. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
9 27746240 Protein kinase Cθ controls type 2 innate lymphoid cell and TH2 responses to house dust mite allergen. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
10 16038795 Basal and induced sphingosine kinase 1 activity in A549 carcinoma cells: function in cell survival and IL-1beta and TNF-alpha induced production of inflammatory mediators. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
11 14689477 Compartmentation of the mouse cerebellar cortex by sphingosine kinase. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
12 19782042 Sphingosine kinase 1 localized to the plasma membrane lipid raft microdomain overcomes serum deprivation induced growth inhibition. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
13 9260867 Cellular relocalisation of protein kinase C-theta caused by staurosporine and some of its analogues. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
14 16233930 Variation of the insulin receptor substrate gene (IRS-1) in African Pygmies and Bantus. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
15 9762362 Inositides in the nucleus: taking stock of PLC beta 1. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
16 28364599 Flavonoids from Enicostema littorale blume enhances glucose uptake of cells in insulin resistant human liver cancer (HepG2) cell line via IRS-1/PI3K/Akt pathway. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
17 20123033 HSP-70 mitigates LPS/SKI-induced cell damage by increasing sphingosine kinase 1 (SK1). Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
18 18815359 A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
19 20525764 Insulin receptor substrate 1 regulates the cellular differentiation and the matrix metallopeptidase expression of preosteoblastic cells. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
20 26217938 BMP-2 Induced Expression of PLCβ1 That is a Positive Regulator of Osteoblast Differentiation. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
21 23955546 Predictive value of sphingosine kinase 1 expression in neoadjuvant treatment of breast cancer. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
22 15085153 Inositide-specific phospholipase c beta1 gene deletion in the progression of myelodysplastic syndrome to acute myeloid leukemia. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
23 12767044 Transgenic mice with dominant negative PKC-theta in skeletal muscle: a new model of insulin resistance and obesity. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
24 23659870 Common variants in and near IRS1 and subclinical cardiovascular disease in the Framingham Heart Study. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
25 28380411 Paeoniflorin suppresses lipid accumulation and alleviates insulin resistance by regulating the Rho kinase/IRS-1 pathway in palmitate-induced HepG2Cells. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
26 28158245 Protein kinase C theta is required for efficient induction of IL-10-secreting T cells. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
27 11464583 The biological significance of phospholipase C beta 1 gene mutation in mouse sperm in the acrosome reaction, fertilization, and embryo development. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
28 18362204 Apoptosis induces expression of sphingosine kinase 1 to release sphingosine-1-phosphate as a "come-and-get-me" signal. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
29 15474310 Disruption of the mouse phospholipase C-beta1 gene in a beta-lactoglobulin transgenic line affects viability, growth, and fertility in mice. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
30 23708959 Association between insulin receptor substrate 1 Gly972Arg polymorphism and cancer risk. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
31 7542742 Association of insulin receptor substrate 1 with simian virus 40 large T antigen. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
32 24452756 Sphingosine kinases/sphingosine-1-phosphate and death Signalling in APP-transfected cells. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
33 26662312 SphK1 promotes tumor cell migration and invasion in colorectal cancer. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
34 30305144 The role of insulin receptor substrate 1 gene polymorphism Gly972Arg as a risk factor for ischemic stroke among Indonesian subjects. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
35 15084656 The role of the theta isoform of protein kinase C (PKC) in activity-dependent synapse elimination: evidence from the PKC theta knock-out mouse in vivo and in vitro. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
36 25404266 [Role of SPHK1 regulates multi-drug resistance of small cell lung cancer â?©and its clinical significance]. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
37 19932089 Sphingosine kinase-1 mediates androgen-induced osteoblast cell growth. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
38 15344880 Inhibition of phosphatidylinositol-3-kinase enhances insulin stimulation of insulin receptor substrate 1 tyrosine phosphorylation and extracellular signal-regulated kinases in mouse R- fibroblasts. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
39 17620288 Spontaneous calcium oscillations and nuclear PLC-beta1 in human GV oocytes. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
40 8444877 Molecular cloning and characterization of PKC theta, a novel member of the protein kinase C (PKC) gene family expressed predominantly in hematopoietic cells. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
41 17725492 The phosphoinositide-phospholipase C (PI-PLC) pathway in the mouse oocyte. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
42 23433459 The yin and yang of protein kinase C-theta (PKCθ): a novel drug target for selective immunosuppression. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
43 20089836 Transforming growth factor-beta1 induces transdifferentiation of myoblasts into myofibroblasts via up-regulation of sphingosine kinase-1/S1P3 axis. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
44 26474286 IGF-1 mediated phosphorylation of specific IRS-1 serines in Ames dwarf fibroblasts is associated with longevity. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
45 26390157 TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
46 8020946 The human insulin receptor substrate-1 gene (IRS1) is localized on 2q36. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
47 28789830 Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension? Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
48 18818393 Imaging of plasmacytoid dendritic cell interactions with T cells. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
49 18973591 Predominant expression of phospholipase Cbeta1 in telencephalic principal neurons and cerebellar interneurons, and its close association with related signaling molecules in somatodendritic neuronal elements. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
50 20498263 Protective Toxoplasma gondii-specific T-cell responses require T-cell-specific expression of protein kinase C-theta. Pubmed 1.309E-4 4.006E-4 3.229E-3
2.328E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 172 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:PRKCD PRKCD interactions 8.428E-6 1.450E-3 8.303E-3 1.450E-3 3 169
2 int:FYN FYN interactions 2.858E-5 2.458E-3 1.408E-2 4.915E-3 3 254
3 int:PRKCQ PRKCQ interactions 6.288E-5 3.605E-3 2.065E-2 1.081E-2 2 45
4 int:ALK ALK interactions 1.529E-4 6.536E-3 3.744E-2 2.631E-2 2 70
5 int:PDPK1 PDPK1 interactions 1.900E-4 6.536E-3 3.744E-2 3.268E-2 2 78
6 int:CBLB CBLB interactions 2.644E-4 7.581E-3 4.342E-2 4.548E-2 2 92
7 int:IRS1 IRS1 interactions 3.314E-4 8.144E-3 4.665E-2
5.701E-2
 2 103
8 int:CHUK CHUK interactions 7.974E-4 1.584E-2
9.070E-2
1.372E-1
 2 160
9 int:MUC15 MUC15 interactions 8.471E-4 1.584E-2
9.070E-2
1.457E-1
 1 3
10 int:IKBKB IKBKB interactions 9.206E-4 1.584E-2
9.070E-2
1.584E-1
 2 172
11 int:LYN LYN interactions 1.666E-3 2.435E-2
1.394E-1
2.866E-1
 2 232
12 int:MAPK3 MAPK3 interactions 2.232E-3 2.435E-2
1.394E-1
3.839E-1
 2 269
13 int:RPS6KC1 RPS6KC1 interactions 2.258E-3 2.435E-2
1.394E-1
3.883E-1
 1 8
14 int:FBXO40 FBXO40 interactions 2.258E-3 2.435E-2
1.394E-1
3.883E-1
 1 8
15 int:SPHKAP SPHKAP interactions 2.258E-3 2.435E-2
1.394E-1
3.883E-1
 1 8
16 int:CBL CBL interactions 2.265E-3 2.435E-2
1.394E-1
3.895E-1
 2 271
17 int:TRIM72 TRIM72 interactions 3.103E-3 2.929E-2
1.678E-1
5.338E-1
 1 11
18 int:TUB TUB interactions 3.385E-3 2.929E-2
1.678E-1
5.822E-1
 1 12
19 int:RASGRP3 RASGRP3 interactions 3.385E-3 2.929E-2
1.678E-1
5.822E-1
 1 12
20 int:MAPK1 MAPK1 interactions 3.560E-3 2.929E-2
1.678E-1
6.123E-1
 2 341
21 int:ICAM3 ICAM3 interactions 4.230E-3 2.929E-2
1.678E-1
7.275E-1
 1 15
22 int:RGS4 RGS4 interactions 4.230E-3 2.929E-2
1.678E-1
7.275E-1
 1 15
23 int:CDS1 CDS1 interactions 4.230E-3 2.929E-2
1.678E-1
7.275E-1
 1 15
24 int:AKT1 AKT1 interactions 4.702E-3 2.929E-2
1.678E-1
8.088E-1
 2 393
25 int:SELL SELL interactions 4.793E-3 2.929E-2
1.678E-1
8.244E-1
 1 17
26 int:DCXR DCXR interactions 4.793E-3 2.929E-2
1.678E-1
8.244E-1
 1 17
27 int:SPHK1 SPHK1 interactions 5.355E-3 2.929E-2
1.678E-1
9.211E-1
 1 19
28 int:KRIT1 KRIT1 interactions 5.355E-3 2.929E-2
1.678E-1
9.211E-1
 1 19
29 int:RGS12 RGS12 interactions 5.355E-3 2.929E-2
1.678E-1
9.211E-1
 1 19
30 int:SH2B1 SH2B1 interactions 5.637E-3 2.929E-2
1.678E-1
9.695E-1
 1 20
31 int:TSPAN6 TSPAN6 interactions 5.637E-3 2.929E-2
1.678E-1
9.695E-1
 1 20
32 int:MBTPS1 MBTPS1 interactions 5.918E-3 2.929E-2
1.678E-1
1.000E0
 1 21
33 int:GRB14 GRB14 interactions 5.918E-3 2.929E-2
1.678E-1
1.000E0
 1 21
34 int:YWHAG YWHAG interactions 5.995E-3 2.929E-2
1.678E-1
1.000E0
 2 445
35 int:C2CD2L C2CD2L interactions 6.199E-3 2.929E-2
1.678E-1
1.000E0
 1 22
36 int:TRPM7 TRPM7 interactions 6.199E-3 2.929E-2
1.678E-1
1.000E0
 1 22
37 int:TRPC3 TRPC3 interactions 6.480E-3 2.929E-2
1.678E-1
1.000E0
 1 23
38 int:ACY1 ACY1 interactions 6.761E-3 2.929E-2
1.678E-1
1.000E0
 1 24
39 int:FYB1 FYB1 interactions 7.042E-3 2.929E-2
1.678E-1
1.000E0
 1 25
40 int:ATP2A1 ATP2A1 interactions 7.323E-3 2.929E-2
1.678E-1
1.000E0
 1 26
41 int:PLCB1 PLCB1 interactions 7.323E-3 2.929E-2
1.678E-1
1.000E0
 1 26
42 int:GRM5 GRM5 interactions 7.323E-3 2.929E-2
1.678E-1
1.000E0
 1 26
43 int:DTX1 DTX1 interactions 7.323E-3 2.929E-2
1.678E-1
1.000E0
 1 26
44 int:CTNND2 CTNND2 interactions 7.884E-3 2.965E-2
1.698E-1
1.000E0
 1 28
45 int:HABP4 HABP4 interactions 8.165E-3 2.965E-2
1.698E-1
1.000E0
 1 29
46 int:PTPRU PTPRU interactions 8.165E-3 2.965E-2
1.698E-1
1.000E0
 1 29
47 int:PELI1 PELI1 interactions 8.165E-3 2.965E-2
1.698E-1
1.000E0
 1 29
48 int:VSIG2 VSIG2 interactions 8.445E-3 2.965E-2
1.698E-1
1.000E0
 1 30
49 int:FER FER interactions 8.445E-3 2.965E-2
1.698E-1
1.000E0
 1 30
50 int:DEF8 DEF8 interactions 9.006E-3 3.034E-2
1.738E-1
1.000E0
 1 32
Show 45 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q25.2 17q25.2 8.653E-4 2.018E-3 4.608E-3 4.326E-3 1 6
2 10p15 10p15 1.009E-3 2.018E-3 4.608E-3 5.047E-3 1 7
3 2q36 2q36 1.298E-3 2.018E-3 4.608E-3 6.488E-3 1 9
4 20p12 20p12 2.018E-3 2.018E-3 4.608E-3 1.009E-2 1 14
5 4q21.23 4q21.23 2.018E-3 2.018E-3 4.608E-3 1.009E-2 1 14

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 52 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 4 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 835 C2 domain containing protein kinases genenames.org 1.648E-3 6.260E-3 1.304E-2 6.592E-3 1 10
2 832 Phospholipases|C2 domain containing phospholipases genenames.org 3.130E-3 6.260E-3 1.304E-2 1.252E-2 1 19
3 467 Phospholipases genenames.org 6.910E-3 9.213E-3 1.919E-2 2.764E-2 1 42
4 682 Zinc fingers FYVE-type|Pleckstrin homology domain containing|Rho guanine nucleotide exchange factors genenames.org 3.359E-2 3.359E-2
6.997E-2
1.343E-1
 1 206

13: Coexpression [Display Chart] 5 input genes in category / 667 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6867 Genes up-regulated during B lymphocyte differentiation: pre-B I versus VPREB1+ [GeneID=7441] large pre-B II. MSigDB C7: Immunologic Signatures (v6.0) 4.232E-4 2.566E-2
1.817E-1
2.823E-1
 2 152
2 M8994 Genes up-regulated in CD4 [GeneID=920] T cells over-expressing FOXP3 [GeneID=50943]: untreated versus pioglitazone [PubChem=4829]. MSigDB C7: Immunologic Signatures (v6.0) 4.457E-4 2.566E-2
1.817E-1
2.973E-1
 2 156
3 M6911 Genes down-regulated in macrophages with IL10 [GeneID=3586] knockout treated by LPS and IL10 [GeneID=3586]: 10 min versus 30 min. MSigDB C7: Immunologic Signatures (v6.0) 4.514E-4 2.566E-2
1.817E-1
3.011E-1
 2 157
4 M2502 Genes whose expression changes in Calu-6 cells (lung cancer) by TNF [GeneID=7124] were blocked partially by p38 inhibitor LY479754. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.688E-4 2.566E-2
1.817E-1
3.127E-1
 2 160
5 17284527-TableS4 Human Lypmhoma Leval07 241genes GeneSigDB 4.805E-4 2.566E-2
1.817E-1
3.205E-1
 2 162
6 18519693-Table1 Human StemCell Mishra08 289genes GeneSigDB 6.059E-4 2.566E-2
1.817E-1
4.041E-1
 2 182
7 M2822 Genes up-regulated in Sez-4 cells (T lymphocyte) that were first starved of IL2 [Gene ID=3558] and then stimulated with IL2 [Gene ID=3558]. MSigDB C6: Oncogenic Signatures (v6.0) 6.669E-4 2.566E-2
1.817E-1
4.448E-1
 2 191
8 M2839 Genes up-regulated in a panel of epithelial cell lines by TGFB1 [Gene ID=7040]. MSigDB C6: Oncogenic Signatures (v6.0) 6.739E-4 2.566E-2
1.817E-1
4.495E-1
 2 192
9 M2726 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) stably over-expressing constitutively active RAF1 [Gene ID=5894] gene. MSigDB C6: Oncogenic Signatures (v6.0) 6.879E-4 2.566E-2
1.817E-1
4.588E-1
 2 194
10 19010862-TableS1 Human Breast Laere08 263genes GeneSigDB 7.164E-4 2.566E-2
1.817E-1
4.778E-1
 2 198
11 M7227 Genes up-regulated in T cells treated with IL21 [GeneID=59067]: 6h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.566E-2
1.817E-1
4.827E-1
 2 199
12 M7505 Genes down-regulated in CD4 [GeneID=920] T cells: non-Tfh versus Tfh (T follicular helper) from germinal center. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
13 M6987 Genes down-regulated in naïve untreated macrophages versus tolerant macrophages stimulated by LPS. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
14 M9970 Genes down-regulated in CD8A [GeneID=925] dendritic cells with IFNAR1 [GeneID=3454] knockout: control versus primary acute viral infection. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
15 M302 Genes up-regulated in primary bronchial epithelial cells: control versus stimulated with IL22 [GeneID=50616]. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
16 M6781 Genes down-regulated in lymph node B lymphocytes: influenza infected versus interferon beta stimulation. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
17 M7230 Genes down-regulated in T cells treated with IL21 [GeneID=59067]: 1h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
18 M6193 Genes down-regulated in polymorphonuclear leukocytes (24h): control versus infection by A. phagocytophilum. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
19 M9968 Genes down-regulated in CD8A [GeneID=925] dendritic cells: control versus primary acute viral infection. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.566E-2
1.817E-1
4.875E-1
 2 200
20 M13273 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.814E-4 3.273E-2
2.318E-1
6.546E-1
 2 232
21 M12816 Genes down-regulated in MDA-MB-453 cells (class A ER(-) [GeneID=2099] breast cancer) after exposure to the androgen R1881 [PubChem=13766]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.058E-3 3.288E-2
2.328E-1
7.059E-1
 2 241
22 M2446 Genes down-regulated in MEF cells (embryonic fibroblast) upon stimulation with TGFB1 [GeneID=7040] for 10 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.085E-3 3.288E-2
2.328E-1
7.235E-1
 2 244
23 M9564 Genes down-regulated in the normal-like subtype of breast cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.296E-3 3.563E-2
2.523E-1
8.645E-1
 1 6
24 16135788-Table13 Human Breast Wang05 410genes up BT-BAF57cells GeneSigDB 1.326E-3 3.563E-2
2.523E-1
8.842E-1
 2 270
25 M2348 Genes up-regulated in leukemic progenitor cells expressing activated fusion of ESWR1 and FLI1 [GeneID=2130, 2313] compared to normal hematopoetic progenitors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.335E-3 3.563E-2
2.523E-1
8.907E-1
 2 271
26 M1804 Genes up-regulated in BT549 cells (breast cancer) by expression of SMARCE1 [GeneID=6605] off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.425E-3 3.655E-2
2.588E-1
9.502E-1
 2 280
27 M1811 Genes important for fertilization, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.728E-3 4.268E-2
3.022E-1
1.000E0
 1 8
Show 22 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 732 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 14 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 5 input genes in category / 218 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-494-3p:TargetScan hsa-miR-494-3p TargetScan 2.316E-6 5.049E-4 3.011E-3 5.049E-4 3 446
2 hsa-miR-487a:PITA hsa-miR-487a:PITA TOP PITA 1.138E-4 5.809E-3 3.464E-2 2.480E-2 2 245
3 hsa-miR-511-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.291E-4 5.809E-3 3.464E-2 2.814E-2 2 261
4 hsa-miR-223-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.528E-4 5.809E-3 3.464E-2 3.331E-2 2 284
5 hsa-miR-491-3p:PITA hsa-miR-491-3p:PITA TOP PITA 1.560E-4 5.809E-3 3.464E-2 3.402E-2 2 287
6 hsa-miR-7-5p:TargetScan hsa-miR-7-5p TargetScan 3.100E-4 5.809E-3 3.464E-2
6.759E-2
 2 405
7 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 3.773E-4 5.809E-3 3.464E-2
8.226E-2
 2 447
8 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 3.773E-4 5.809E-3 3.464E-2
8.226E-2
 2 447
9 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 3.943E-4 5.809E-3 3.464E-2
8.596E-2
 2 457
10 hsa-miR-6867-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.978E-4 5.809E-3 3.464E-2
8.671E-2
 2 459
11 hsa-miR-1297:PITA hsa-miR-1297:PITA TOP PITA 4.222E-4 5.809E-3 3.464E-2
9.205E-2
 2 473
12 hsa-miR-26a:PITA hsa-miR-26a:PITA TOP PITA 4.222E-4 5.809E-3 3.464E-2
9.205E-2
 2 473
13 hsa-miR-26b:PITA hsa-miR-26b:PITA TOP PITA 4.222E-4 5.809E-3 3.464E-2
9.205E-2
 2 473
14 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 4.402E-4 5.809E-3 3.464E-2
9.596E-2
 2 483
15 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 4.402E-4 5.809E-3 3.464E-2
9.596E-2
 2 483
16 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 4.402E-4 5.809E-3 3.464E-2
9.596E-2
 2 483
17 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 4.530E-4 5.809E-3 3.464E-2
9.875E-2
 2 490
18 hsa-miR-487b-3p:TargetScan hsa-miR-487b-3p TargetScan 7.611E-4 9.218E-3
5.498E-2
1.659E-1
 1 11
19 hsa-miR-516a-5p:PITA hsa-miR-516a-5p:PITA TOP PITA 1.038E-3 1.191E-2
7.101E-2
2.262E-1
 1 15
20 hsa-miR-614:PITA hsa-miR-614:PITA TOP PITA 1.176E-3 1.282E-2
7.646E-2
2.564E-1
 1 17
21 hsa-miR-126-3p.1:TargetScan hsa-miR-126-3p.1 TargetScan 1.660E-3 1.723E-2
1.028E-1
3.619E-1
 1 24
22 hsa-miR-487b:PITA hsa-miR-487b:PITA TOP PITA 2.075E-3 2.056E-2
1.226E-1
4.523E-1
 1 30
23 hsa-miR-1225-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.489E-3 2.359E-2
1.407E-1
5.427E-1
 1 36
24 hsa-miR-628-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.525E-3 2.940E-2
1.754E-1
7.684E-1
 1 51
25 hsa-miR-4777-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.594E-3 2.940E-2
1.754E-1
7.835E-1
 1 52
26 hsa-miR-4676-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.870E-3 2.940E-2
1.754E-1
8.437E-1
 1 56
27 hsa-miR-892c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.939E-3 2.940E-2
1.754E-1
8.587E-1
 1 57
28 hsa-miR-126-3p:Functional MTI Functional MTI miRTarbase 3.939E-3 2.940E-2
1.754E-1
8.587E-1
 1 57
29 ATCTTGC,MIR-31:MSigDB ATCTTGC,MIR-31:MSigDB MSigDB 4.491E-3 2.940E-2
1.754E-1
9.790E-1
 1 65
30 hsa-miR-659-3p:Functional MTI Functional MTI miRTarbase 4.698E-3 2.940E-2
1.754E-1
1.000E0
 1 68
31 hsa-miR-501-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.767E-3 2.940E-2
1.754E-1
1.000E0
 1 69
32 hsa-miR-3607-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.974E-3 2.940E-2
1.754E-1
1.000E0
 1 72
33 CTCAAGA,MIR-526B:MSigDB CTCAAGA,MIR-526B:MSigDB MSigDB 4.974E-3 2.940E-2
1.754E-1
1.000E0
 1 72
34 hsa-miR-875-5p:TargetScan hsa-miR-875-5p TargetScan 5.042E-3 2.940E-2
1.754E-1
1.000E0
 1 73
35 hsa-miR-502-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.111E-3 2.940E-2
1.754E-1
1.000E0
 1 74
36 hsa-miR-125b-1*:mirSVR highEffct hsa-miR-125b-1*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.111E-3 2.940E-2
1.754E-1
1.000E0
 1 74
37 hsa-miR-452-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.180E-3 2.940E-2
1.754E-1
1.000E0
 1 75
38 AGGGCCA,MIR-328:MSigDB AGGGCCA,MIR-328:MSigDB MSigDB 5.180E-3 2.940E-2
1.754E-1
1.000E0
 1 75
39 hsa-miR-1225-5p:PITA hsa-miR-1225-5p:PITA TOP PITA 6.007E-3 2.940E-2
1.754E-1
1.000E0
 1 87
40 hsa-miR-223-3p:Functional MTI Functional MTI miRTarbase 6.765E-3 2.940E-2
1.754E-1
1.000E0
 1 98
41 hsa-let-7f-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.833E-3 2.940E-2
1.754E-1
1.000E0
 1 99
42 hsa-miR-384:Non-Functional MTI Non-Functional MTI miRTarbase 6.971E-3 2.940E-2
1.754E-1
1.000E0
 1 101
43 AGGAAGC,MIR-516-3P:MSigDB AGGAAGC,MIR-516-3P:MSigDB MSigDB 7.315E-3 2.940E-2
1.754E-1
1.000E0
 1 106
44 hsa-miR-105-5p:Functional MTI Functional MTI miRTarbase 7.384E-3 2.940E-2
1.754E-1
1.000E0
 1 107
45 hsa-miR-324-5p:TargetScan hsa-miR-324-5p TargetScan 7.659E-3 2.940E-2
1.754E-1
1.000E0
 1 111
46 hsa-miR-875-5p:PITA hsa-miR-875-5p:PITA TOP PITA 7.866E-3 2.940E-2
1.754E-1
1.000E0
 1 114
47 hsa-miR-1185-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.072E-3 2.940E-2
1.754E-1
1.000E0
 1 117
48 hsa-miR-589:PITA hsa-miR-589:PITA TOP PITA 8.141E-3 2.940E-2
1.754E-1
1.000E0
 1 118
49 hsa-miR-423-5p:PITA hsa-miR-423-5p:PITA TOP PITA 8.141E-3 2.940E-2
1.754E-1
1.000E0
 1 118
50 hsa-miR-1185-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.278E-3 2.940E-2
1.754E-1
1.000E0
 1 120
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 2488 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000445141 AC1L9HHR Stitch 2.802E-7 6.972E-4 5.854E-3 6.972E-4 4 354
2 CID005460104 phosphatidate Stitch 6.274E-7 7.805E-4 6.554E-3 1.561E-3 4 433
3 CID000096400 naphthalene-2,3-dicarboxaldehyde Stitch 2.107E-6 1.747E-3 1.467E-2 5.242E-3 2 11
4 CID006857352 AC1OAGFW Stitch 5.166E-6 3.057E-3 2.567E-2 1.285E-2 3 185
5 3094 DN S-(+)-ibuprofen [51146-56-6]; Down 200; 19.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 6.144E-6 3.057E-3 2.567E-2 1.529E-2 3 196
6 CID009543520 triphosphoinositide Stitch 1.659E-5 6.567E-3
5.514E-2
 4.128E-2 3 273
7 CID000002399 BiM4 Stitch 1.848E-5 6.567E-3
5.514E-2
 4.597E-2 3 283
8 CID005281656 norathyriol Stitch 2.545E-5 7.916E-3
6.647E-2
6.333E-2
 2 37
9 CID000006026 kinin 9 Stitch 3.888E-5 1.075E-2
9.024E-2
9.673E-2
 3 363
10 CID000006268 thiomalate Stitch 4.677E-5 1.089E-2
9.146E-2
1.164E-1
 2 50
11 CID000001104 (2S,3R)-Sphingosine Stitch 4.816E-5 1.089E-2
9.146E-2
1.198E-1
 3 390
12 CID000005262 AC1L1JYL Stitch 6.668E-5 1.365E-2
1.147E-1
1.659E-1
 3 435
13 CID000005711 Y-27632 Stitch 7.135E-5 1.365E-2
1.147E-1
1.775E-1
 3 445
14 ctd:D020001 1-Butanol CTD 9.469E-5 1.435E-2
1.205E-1
2.356E-1
 2 71
15 CID005207744 AC1NPP2V Stitch 1.264E-4 1.435E-2
1.205E-1
3.146E-1
 2 82
16 CID000006104 aurothioglucose Stitch 1.558E-4 1.435E-2
1.205E-1
3.876E-1
 2 91
17 CID000028683 4 alpha-phorbol Stitch 1.996E-4 1.435E-2
1.205E-1
4.966E-1
 2 103
18 CID000003954 loperamide Stitch 2.074E-4 1.435E-2
1.205E-1
5.161E-1
 2 105
19 CID000005206 sevoflurane Stitch 2.074E-4 1.435E-2
1.205E-1
5.161E-1
 2 105
20 CID000073977 tin(4+) disulfide Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
21 CID000015650 3-methylcyclopentanone Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
22 CID001605514 GABA benzyl ester Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
23 CID000473555 terephthaloylbisglycine Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
24 CID000013596 N-methylpyridinium iodide Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
25 CID000014494 1,10-decanedithiol Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
26 CID000066290 cadmium myristate Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
27 CID000160477 elliptone Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
28 CID005391199 2,2'-bipyridine-3,3'-diol Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
29 CID000192591 diisovaleryl tert-butalone Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
30 CID000082604 nicotinoyl chloride Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
31 CID003014902 cadmium acrylate Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
32 CID000068280 diphenylbenzidine Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
33 CID000100096 NSC334189 Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
34 CID000010299 p-chloromandelic acid Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
35 CID000098116 cinnamyl bromide Stitch 2.189E-4 1.435E-2
1.205E-1
5.446E-1
 1 1
36 CID000000009 AC1Q6SH8 Stitch 2.532E-4 1.435E-2
1.205E-1
6.299E-1
 2 116
37 CID000026924 Florisil Stitch 3.377E-4 1.435E-2
1.205E-1
8.402E-1
 2 134
38 CID000004330 ICE inhibitor Stitch 4.007E-4 1.435E-2
1.205E-1
9.970E-1
 2 146
39 CID000003126 dihydrosphingosine Stitch 4.062E-4 1.435E-2
1.205E-1
1.000E0
 2 147
40 CID000073212 lead compounds Stitch 4.229E-4 1.435E-2
1.205E-1
1.000E0
 2 150
41 ctd:C512927 bis(alpha-furancarboxylato)oxovanadium(IV) CTD 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
42 CID000067383 CDS-E2 Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
43 CID000075121 phenyl methacrylate Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
44 CID000080526 octadecyl ether Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
45 CID000015537 acid violet Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
46 CID000521305 ACE-Cl Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
47 CID000061294 Octyl caprylate Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
48 CID000101325 2-anthracenecarboxylate Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
49 CID005316124 coumingine Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
50 CID000063079 PCB 163 Stitch 4.378E-4 1.435E-2
1.205E-1
1.000E0
 1 2
Show 45 more annotations

18: Disease [Display Chart] 5 input genes in category / 153 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C3150988 Early infantile epileptic encephalopathy 12 Clinical Variations 3.085E-4 2.360E-2
1.324E-1
 4.721E-2 1 1
2 C3150988 EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 12 DisGeNET Curated 3.085E-4 2.360E-2
1.324E-1
 4.721E-2 1 1
3 C0270844 Seizures, Tonic DisGeNET BeFree 9.254E-4 3.302E-2
1.853E-1
1.416E-1
 1 3
4 C0206686 Adrenocortical carcinoma DisGeNET Curated 1.010E-3 3.302E-2
1.853E-1
1.545E-1
 2 165
5 C1955860 Leukemia, Natural Killer Cell Large Granular Lymphocytic DisGeNET BeFree 1.234E-3 3.302E-2
1.853E-1
1.888E-1
 1 4
6 C3494976 Migrating partial seizures in infancy DisGeNET BeFree 1.542E-3 3.302E-2
1.853E-1
2.359E-1
 1 5
7 C1859844 LEBER CONGENITAL AMAUROSIS, TYPE II (disorder) DisGeNET Curated 1.542E-3 3.302E-2
1.853E-1
2.359E-1
 1 5
8 C1512709 Chronic Lymphoproliferative Disorder of NK-Cells DisGeNET BeFree 1.850E-3 3.302E-2
1.853E-1
2.831E-1
 1 6
9 20081125:Raychaudhuri Rheumatoid arthritis GWAS 2.158E-3 3.302E-2
1.853E-1
3.302E-1
 1 7
10 C1377913 Pleural Mesothelioma DisGeNET BeFree 2.158E-3 3.302E-2
1.853E-1
3.302E-1
 1 7
11 C0812413 Malignant Pleural Mesothelioma DisGeNET BeFree 2.522E-3 3.507E-2
1.968E-1
3.858E-1
 2 262
12 C1833488 Generalized seizures, recurrent DisGeNET Curated 2.774E-3 3.537E-2
1.985E-1
4.244E-1
 1 9
13 C1112160 Gastrooesophageal cancer DisGeNET BeFree 3.082E-3 3.627E-2
2.035E-1
4.716E-1
 1 10
14 C0393570 Corticobasal degeneration DisGeNET BeFree 4.005E-3 3.992E-2
2.240E-1
6.128E-1
 1 13
15 C2931919 X-linked infantile spasm syndrome DisGeNET BeFree 4.005E-3 3.992E-2
2.240E-1
6.128E-1
 1 13
16 C0948750 Salivary gland carcinoma DisGeNET BeFree 4.928E-3 3.992E-2
2.240E-1
7.539E-1
 1 16
17 20081125:Cooper Type 1 diabetes GWAS 5.235E-3 3.992E-2
2.240E-1
8.009E-1
 1 17
18 C3887611 Restlessness DisGeNET Curated 5.542E-3 3.992E-2
2.240E-1
8.480E-1
 1 18
19 C0025517 Metabolic Diseases DisGeNET Curated 5.645E-3 3.992E-2
2.240E-1
8.636E-1
 2 395
20 C0221269 Pseudolymphoma DisGeNET BeFree 6.156E-3 3.992E-2
2.240E-1
9.419E-1
 1 20
21 C0010051 Coronary Aneurysm DisGeNET Curated 6.464E-3 3.992E-2
2.240E-1
9.889E-1
 1 21
22 C0085631 Agitation DisGeNET Curated 6.770E-3 3.992E-2
2.240E-1
1.000E0
 1 22
23 C0234533 Generalized seizures DisGeNET Curated 6.770E-3 3.992E-2
2.240E-1
1.000E0
 1 22
24 C0342782 Depletion of mitochondrial DNA DisGeNET BeFree 7.077E-3 3.992E-2
2.240E-1
1.000E0
 1 23
25 C0020456 Hyperglycemia DisGeNET Curated 7.278E-3 3.992E-2
2.240E-1
1.000E0
 2 450
26 C0342541 Precocious pubarche DisGeNET Curated 7.384E-3 3.992E-2
2.240E-1
1.000E0
 1 24
27 C4049711 Lepidic Predominant Adenocarcinoma DisGeNET BeFree 7.384E-3 3.992E-2
2.240E-1
1.000E0
 1 24
28 C0684276 Hypsarrhythmia DisGeNET Curated 7.691E-3 3.992E-2
2.240E-1
1.000E0
 1 25
29 20090601:Barrett Type 1 diabetes GWAS 7.691E-3 3.992E-2
2.240E-1
1.000E0
 1 25
30 C0007115 Malignant neoplasm of thyroid DisGeNET BeFree 8.251E-3 3.992E-2
2.240E-1
1.000E0
 2 480
31 C0751495 Seizures, Focal DisGeNET Curated 8.304E-3 3.992E-2
2.240E-1
1.000E0
 1 27
32 C4054121 Rat Insulinoma DisGeNET BeFree 8.611E-3 3.992E-2
2.240E-1
1.000E0
 1 28
33 cv:C0011860 Diabetes mellitus type 2 Clinical Variations 8.611E-3 3.992E-2
2.240E-1
1.000E0
 1 28
34 C0175704 LEOPARD Syndrome DisGeNET Curated 8.917E-3 4.013E-2
2.251E-1
1.000E0
 1 29
35 OMIN:125853 DIABETES MELLITUS, NONINSULIN-DEPENDENT; NIDDM OMIM 1.045E-2 4.567E-2
2.563E-1
1.000E0
 1 34
36 C3887898 Infantile Spasm DisGeNET Curated 1.137E-2 4.830E-2
2.710E-1
1.000E0
 1 37
Show 31 more annotations