Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc154_14, positive side

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1: GO: Molecular Function [Display Chart] 14 input genes in category / 38 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0061631 ubiquitin conjugating enzyme activity 5.421E-37 1.735E-35 7.334E-35 2.060E-35 13 31
2 GO:0061650 ubiquitin-like protein conjugating enzyme activity 9.130E-37 1.735E-35 7.334E-35 3.469E-35 13 32
3 GO:0004842 ubiquitin-protein transferase activity 5.630E-24 7.132E-23 3.015E-22 2.139E-22 14 414
4 GO:0019787 ubiquitin-like protein transferase activity 1.382E-23 1.313E-22 5.552E-22 5.253E-22 14 441
5 GO:0031625 ubiquitin protein ligase binding 5.054E-14 3.652E-13 1.544E-12 1.921E-12 9 273
6 GO:0044389 ubiquitin-like protein ligase binding 5.767E-14 3.652E-13 1.544E-12 2.191E-12 9 277
7 GO:0061630 ubiquitin protein ligase activity 6.885E-13 3.738E-12 1.580E-11 2.616E-11 8 212
8 GO:0061659 ubiquitin-like protein ligase activity 8.311E-13 3.948E-12 1.669E-11 3.158E-11 8 217
9 GO:0043130 ubiquitin binding 2.886E-3 1.036E-2 4.378E-2
1.097E-1
 2 108
10 GO:0019788 NEDD8 transferase activity 2.998E-3 1.036E-2 4.378E-2
1.139E-1
 1 4
11 GO:0042296 ISG15 transferase activity 2.998E-3 1.036E-2 4.378E-2
1.139E-1
 1 4
12 GO:0032182 ubiquitin-like protein binding 3.964E-3 1.255E-2
5.307E-2
1.506E-1
 2 127
13 GO:0097027 ubiquitin-protein transferase activator activity 7.479E-3 2.090E-2
8.835E-2
2.842E-1
 1 10
14 GO:0034450 ubiquitin-ubiquitin ligase activity 9.712E-3 2.090E-2
8.835E-2
3.691E-1
 1 13
15 GO:0055106 ubiquitin-protein transferase regulator activity 1.120E-2 2.090E-2
8.835E-2
4.256E-1
 1 15
16 GO:0055103 ligase regulator activity 1.194E-2 2.090E-2
8.835E-2
4.538E-1
 1 16
17 GO:0070735 protein-glycine ligase activity 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
18 GO:0043773 coenzyme F420-0 gamma-glutamyl ligase activity 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
19 GO:0008766 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
20 GO:0070736 protein-glycine ligase activity, initiating 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
21 GO:0018169 ribosomal S6-glutamic acid ligase activity 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
22 GO:0070737 protein-glycine ligase activity, elongating 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
23 GO:0043774 coenzyme F420-2 alpha-glutamyl ligase activity 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
24 GO:0070738 tubulin-glycine ligase activity 1.375E-2 2.090E-2
8.835E-2
5.226E-1
 2 242
25 GO:0070740 tubulin-glutamic acid ligase activity 1.408E-2 2.090E-2
8.835E-2
5.350E-1
 2 245
26 GO:0070739 protein-glutamic acid ligase activity 1.430E-2 2.090E-2
8.835E-2
5.433E-1
 2 247
27 GO:0016881 acid-amino acid ligase activity 1.542E-2 2.170E-2
9.173E-2
5.858E-1
 2 257
28 GO:0016879 ligase activity, forming carbon-nitrogen bonds 1.974E-2 2.679E-2
1.133E-1
7.501E-1
 2 293
29 GO:0031624 ubiquitin conjugating enzyme binding 2.448E-2 3.208E-2
1.356E-1
9.304E-1
 1 33
30 GO:0044390 ubiquitin-like protein conjugating enzyme binding 2.668E-2 3.380E-2
1.429E-1
1.000E0
 1 36
31 GO:0016874 ligase activity 3.763E-2 4.613E-2
1.950E-1
1.000E0
 2 415
Show 26 more annotations

2: GO: Biological Process [Display Chart] 14 input genes in category / 302 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000209 protein polyubiquitination 2.837E-21 8.569E-19 5.389E-18 8.569E-19 12 254
2 GO:0070936 protein K48-linked ubiquitination 1.888E-15 2.852E-13 1.793E-12 5.703E-13 7 49
3 GO:0070534 protein K63-linked ubiquitination 1.290E-10 1.299E-8 8.168E-8 3.896E-8 5 45
4 GO:0006301 postreplication repair 3.327E-10 2.512E-8 1.580E-7 1.005E-7 5 54
5 GO:0070979 protein K11-linked ubiquitination 3.472E-9 2.097E-7 1.319E-6 1.049E-6 4 27
6 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process 5.339E-9 2.687E-7 1.690E-6 1.612E-6 7 393
7 GO:0010498 proteasomal protein catabolic process 8.736E-9 3.769E-7 2.370E-6 2.638E-6 7 422
8 GO:0016574 histone ubiquitination 1.991E-8 7.518E-7 4.728E-6 6.014E-6 4 41
9 GO:0045089 positive regulation of innate immune response 4.941E-8 1.658E-6 1.043E-5 1.492E-5 6 305
10 GO:0051865 protein autoubiquitination 5.729E-8 1.698E-6 1.068E-5 1.730E-5 4 53
11 GO:0006513 protein monoubiquitination 6.184E-8 1.698E-6 1.068E-5 1.868E-5 4 54
12 GO:0002221 pattern recognition receptor signaling pathway 9.355E-8 2.354E-6 1.481E-5 2.825E-5 5 164
13 GO:0045088 regulation of innate immune response 1.678E-7 3.899E-6 2.452E-5 5.068E-5 6 375
14 GO:0031349 positive regulation of defense response 3.605E-7 7.777E-6 4.891E-5 1.089E-4 6 427
15 GO:0042275 error-free postreplication DNA repair 5.248E-7 1.057E-5 6.645E-5 1.585E-4 2 2
16 GO:0002758 innate immune response-activating signal transduction 7.301E-7 1.378E-5 8.667E-5 2.205E-4 5 248
17 GO:0051443 positive regulation of ubiquitin-protein transferase activity 8.465E-7 1.399E-5 8.797E-5 2.556E-4 4 103
18 GO:0002218 activation of innate immune response 8.540E-7 1.399E-5 8.797E-5 2.579E-4 5 256
19 GO:0002223 stimulatory C-type lectin receptor signaling pathway 8.800E-7 1.399E-5 8.797E-5 2.658E-4 4 104
20 GO:0035666 TRIF-dependent toll-like receptor signaling pathway 9.788E-7 1.418E-5 8.921E-5 2.956E-4 3 27
21 GO:0002220 innate immune response activating cell surface receptor signaling pathway 9.864E-7 1.418E-5 8.921E-5 2.979E-4 4 107
22 GO:0051351 positive regulation of ligase activity 1.062E-6 1.458E-5 9.172E-5 3.208E-4 4 109
23 GO:0002756 MyD88-independent toll-like receptor signaling pathway 1.501E-6 1.965E-5 1.236E-4 4.534E-4 3 31
24 GO:0051438 regulation of ubiquitin-protein transferase activity 1.561E-6 1.965E-5 1.236E-4 4.715E-4 4 120
25 GO:0051340 regulation of ligase activity 1.723E-6 2.082E-5 1.309E-4 5.204E-4 4 123
26 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia 1.821E-6 2.115E-5 1.330E-4 5.499E-4 3 33
27 GO:0038095 Fc-epsilon receptor signaling pathway 3.056E-6 3.419E-5 2.150E-4 9.231E-4 4 142
28 GO:0050852 T cell receptor signaling pathway 7.007E-6 7.558E-5 4.753E-4 2.116E-3 4 175
29 GO:0031398 positive regulation of protein ubiquitination 9.500E-6 9.893E-5 6.222E-4 2.869E-3 4 189
30 GO:1903322 positive regulation of protein modification by small protein conjugation or removal 1.335E-5 1.294E-4 8.140E-4 4.030E-3 4 206
31 GO:0038093 Fc receptor signaling pathway 1.335E-5 1.294E-4 8.140E-4 4.030E-3 4 206
32 GO:0043618 regulation of transcription from RNA polymerase II promoter in response to stress 1.371E-5 1.294E-4 8.140E-4 4.142E-3 3 64
33 GO:0002757 immune response-activating signal transduction 1.611E-5 1.475E-4 9.275E-4 4.867E-3 5 467
34 GO:0043620 regulation of DNA-templated transcription in response to stress 1.797E-5 1.596E-4 1.004E-3 5.427E-3 3 70
35 GO:0050851 antigen receptor-mediated signaling pathway 2.166E-5 1.869E-4 1.176E-3 6.542E-3 4 233
36 GO:0006282 regulation of DNA repair 2.586E-5 2.169E-4 1.364E-3 7.809E-3 3 79
37 GO:1903050 regulation of proteolysis involved in cellular protein catabolic process 3.693E-5 2.935E-4 1.846E-3 1.115E-2 4 267
38 GO:0031396 regulation of protein ubiquitination 3.693E-5 2.935E-4 1.846E-3 1.115E-2 4 267
39 GO:1903362 regulation of cellular protein catabolic process 4.895E-5 3.791E-4 2.384E-3 1.478E-2 4 287
40 GO:1903320 regulation of protein modification by small protein conjugation or removal 5.098E-5 3.849E-4 2.421E-3 1.539E-2 4 290
41 GO:0002429 immune response-activating cell surface receptor signaling pathway 8.621E-5 6.350E-4 3.994E-3 2.604E-2 4 332
42 GO:0033522 histone H2A ubiquitination 8.909E-5 6.406E-4 4.029E-3 2.690E-2 2 19
43 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 9.781E-5 6.823E-4 4.291E-3 2.954E-2 4 343
44 GO:0002224 toll-like receptor signaling pathway 9.940E-5 6.823E-4 4.291E-3 3.002E-2 3 124
45 GO:0000729 DNA double-strand break processing 1.093E-4 7.336E-4 4.614E-3 3.301E-2 2 21
46 GO:0002768 immune response-regulating cell surface receptor signaling pathway 1.257E-4 8.247E-4 5.187E-3 3.796E-2 4 366
47 GO:0051052 regulation of DNA metabolic process 1.284E-4 8.247E-4 5.187E-3 3.876E-2 4 368
48 GO:0071456 cellular response to hypoxia 1.517E-4 9.542E-4 6.002E-3 4.580E-2 3 143
49 GO:0036294 cellular response to decreased oxygen levels 1.747E-4 1.076E-3 6.767E-3
5.275E-2
 3 150
50 GO:0030509 BMP signaling pathway 1.781E-4 1.076E-3 6.767E-3
5.380E-2
 3 151
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 14 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031371 ubiquitin conjugating enzyme complex 1.202E-14 2.644E-13 9.758E-13 2.644E-13 5 9
2 GO:0000151 ubiquitin ligase complex 4.589E-12 5.048E-11 1.863E-10 1.010E-10 8 274
3 GO:0031372 UBC13-MMS2 complex 5.010E-7 2.755E-6 1.017E-5 1.102E-5 2 2
4 GO:0035370 UBC13-UEV1A complex 5.010E-7 2.755E-6 1.017E-5 1.102E-5 2 2
5 GO:0033503 HULC complex 5.003E-6 2.201E-5 8.125E-5 1.101E-4 2 5
6 GO:0001741 XY body 6.770E-5 2.482E-4 9.162E-4 1.489E-3 2 17
7 GO:0000803 sex chromosome 2.454E-4 7.712E-4 2.846E-3 5.398E-3 2 32
8 GO:0000792 heterochromatin 1.808E-3 4.973E-3 1.836E-2 3.979E-2 2 87
9 GO:0032433 filopodium tip 1.096E-2 2.680E-2
9.892E-2
2.412E-1
 1 15
Show 4 more annotations

4: Human Phenotype [Display Chart] 1 input genes in category / 85 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 10 input genes in category / 152 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 14 input genes in category / 22 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF00179 UQ con Pfam 2.013E-39 2.587E-38 9.547E-38 4.429E-38 14 39
2 PS00183 UBIQUITIN CONJUGAT 1 PROSITE 3.097E-39 2.587E-38 9.547E-38 6.814E-38 14 40
3 PS50127 UBIQUITIN CONJUGAT 2 PROSITE 4.703E-39 2.587E-38 9.547E-38 1.035E-37 14 41
4 IPR000608 UBQ-conjugat E2 InterPro 4.703E-39 2.587E-38 9.547E-38 1.035E-37 14 41
5 3.10.110.10 - Gene3D 1.188E-33 5.226E-33 1.929E-32 2.613E-32 13 51
6 IPR016135 UBQ-conjugating enzyme/RWD InterPro 2.098E-33 7.694E-33 2.840E-32 4.616E-32 13 53
7 IPR023313 UBQ-conjugating AS InterPro 2.228E-27 7.001E-27 2.584E-26 4.901E-26 10 25
8 PF12356 BIRC6 Pfam 7.473E-4 1.827E-3 6.742E-3 1.644E-2 1 1
9 IPR022103 BIRC6 InterPro 7.473E-4 1.827E-3 6.742E-3 1.644E-2 1 1
10 1.10.1170.10 - Gene3D 5.964E-3 8.747E-3 3.228E-2
1.312E-1
 1 8
11 IPR001370 BIR rpt InterPro 5.964E-3 8.747E-3 3.228E-2
1.312E-1
 1 8
12 PS01282 BIR REPEAT 1 PROSITE 5.964E-3 8.747E-3 3.228E-2
1.312E-1
 1 8
13 PS50143 BIR REPEAT 2 PROSITE 5.964E-3 8.747E-3 3.228E-2
1.312E-1
 1 8
14 PF00653 BIR Pfam 5.964E-3 8.747E-3 3.228E-2
1.312E-1
 1 8
15 SM00238 BIR SMART 5.964E-3 8.747E-3 3.228E-2
1.312E-1
 1 8
16 SM00165 UBA SMART 2.219E-2 3.052E-2
1.126E-1
4.883E-1
 1 30
17 PF00627 UBA Pfam 2.658E-2 3.439E-2
1.269E-1
5.847E-1
 1 36
18 IPR015940 UBA InterPro 3.239E-2 3.959E-2
1.461E-1
7.127E-1
 1 44
19 PS50030 UBA PROSITE 3.457E-2 4.002E-2
1.477E-1
7.605E-1
 1 47
Show 14 more annotations

7: Pathway [Display Chart] 14 input genes in category / 122 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00060 Ubiquitin proteasome pathway PantherDB 1.287E-22 1.052E-20 5.663E-20 1.570E-20 10 45
2 83056 Ubiquitin mediated proteolysis BioSystems: KEGG 1.724E-22 1.052E-20 5.663E-20 2.103E-20 12 137
3 1269193 Antigen processing: Ubiquitination & Proteasome degradation BioSystems: REACTOME 1.789E-20 7.274E-19 3.917E-18 2.182E-18 13 314
4 1269192 Class I MHC mediated antigen processing & presentation BioSystems: REACTOME 1.932E-19 5.893E-18 3.174E-17 2.357E-17 13 376
5 1457808 Protein ubiquitination BioSystems: REACTOME 2.018E-18 4.923E-17 2.651E-16 2.461E-16 9 62
6 1470927 E3 ubiquitin ligases ubiquitinate target proteins BioSystems: REACTOME 2.445E-17 4.972E-16 2.678E-15 2.983E-15 8 42
7 1457809 Synthesis of active ubiquitin: roles of E1 and E2 enzymes BioSystems: REACTOME 7.522E-16 1.311E-14 7.060E-14 9.177E-14 7 30
8 1269223 IKK complex recruitment mediated by RIP1 BioSystems: REACTOME 3.378E-11 5.151E-10 2.774E-9 4.121E-9 5 24
9 1269221 TRIF-mediated TLR3/TLR4 signaling BioSystems: REACTOME 5.432E-8 5.869E-7 3.161E-6 6.627E-6 5 99
10 1269220 MyD88-independent TLR3/TLR4 cascade BioSystems: REACTOME 5.432E-8 5.869E-7 3.161E-6 6.627E-6 5 99
11 1269219 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 5.432E-8 5.869E-7 3.161E-6 6.627E-6 5 99
12 1269264 Negative regulators of RIG-I/MDA5 signaling BioSystems: REACTOME 5.773E-8 5.869E-7 3.161E-6 7.043E-6 4 36
13 1269304 CLEC7A (Dectin-1) signaling BioSystems: REACTOME 6.632E-8 6.224E-7 3.352E-6 8.091E-6 5 103
14 1269236 Activated TLR4 signalling BioSystems: REACTOME 1.154E-7 1.006E-6 5.417E-6 1.408E-5 5 115
15 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 1.825E-7 1.484E-6 7.992E-6 2.226E-5 5 126
16 1269303 C-type lectin receptors (CLRs) BioSystems: REACTOME 3.939E-7 3.004E-6 1.617E-5 4.806E-5 5 147
17 1269204 Toll-Like Receptors Cascades BioSystems: REACTOME 4.807E-7 3.450E-6 1.858E-5 5.864E-5 5 153
18 1269259 RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways BioSystems: REACTOME 1.833E-6 1.243E-5 6.692E-5 2.237E-4 4 84
19 1269301 FCERI mediated NF-kB activation BioSystems: REACTOME 2.111E-6 1.355E-5 7.299E-5 2.575E-4 4 87
20 1208955 protein ubiquitylation BioSystems: BIOCYC 4.066E-6 2.411E-5 1.298E-4 4.960E-4 3 29
21 1269176 Downstream TCR signaling BioSystems: REACTOME 4.150E-6 2.411E-5 1.298E-4 5.063E-4 4 103
22 138013 Internalization of ErbB1 BioSystems: Pathway Interaction Database 6.636E-6 3.680E-5 1.982E-4 8.096E-4 3 34
23 1269172 TCR signaling BioSystems: REACTOME 8.687E-6 4.608E-5 2.481E-4 1.060E-3 4 124
24 1270418 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha BioSystems: REACTOME 5.677E-5 2.886E-4 1.554E-3 6.926E-3 3 69
25 1269742 Cell Cycle Checkpoints BioSystems: REACTOME 6.160E-5 2.901E-4 1.563E-3 7.515E-3 4 204
26 1269208 IRAK1 recruits IKK complex BioSystems: REACTOME 6.421E-5 2.901E-4 1.563E-3 7.834E-3 2 11
27 1269230 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation BioSystems: REACTOME 6.421E-5 2.901E-4 1.563E-3 7.834E-3 2 11
28 1269232 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling BioSystems: REACTOME 7.701E-5 3.317E-4 1.786E-3 9.395E-3 2 12
29 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 7.884E-5 3.317E-4 1.786E-3 9.618E-3 3 77
30 1270415 Cellular response to hypoxia BioSystems: REACTOME 8.512E-5 3.350E-4 1.804E-3 1.038E-2 3 79
31 1270416 Regulation of Hypoxia-inducible Factor (HIF) by oxygen BioSystems: REACTOME 8.512E-5 3.350E-4 1.804E-3 1.038E-2 3 79
32 1269212 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 BioSystems: REACTOME 1.986E-4 7.127E-4 3.838E-3 2.423E-2 2 19
33 1269843 Phosphorylation of the APC/C BioSystems: REACTOME 1.986E-4 7.127E-4 3.838E-3 2.423E-2 2 19
34 1269850 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase BioSystems: REACTOME 1.986E-4 7.127E-4 3.838E-3 2.423E-2 2 19
35 1269762 Inactivation of APC/C via direct inhibition of the APC/C complex BioSystems: REACTOME 2.205E-4 7.272E-4 3.916E-3 2.691E-2 2 20
36 1269213 activated TAK1 mediates p38 MAPK activation BioSystems: REACTOME 2.205E-4 7.272E-4 3.916E-3 2.691E-2 2 20
37 1269761 Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components BioSystems: REACTOME 2.205E-4 7.272E-4 3.916E-3 2.691E-2 2 20
38 1269758 Mitotic Spindle Checkpoint BioSystems: REACTOME 2.436E-4 7.821E-4 4.212E-3 2.972E-2 2 21
39 1269529 Downregulation of SMAD2/3:SMAD4 transcriptional activity BioSystems: REACTOME 2.931E-4 8.940E-4 4.814E-3 3.576E-2 2 23
40 1269848 APC/C:Cdc20 mediated degradation of Cyclin B BioSystems: REACTOME 2.931E-4 8.940E-4 4.814E-3 3.576E-2 2 23
41 1269522 Signaling by BMP BioSystems: REACTOME 3.195E-4 9.508E-4 5.121E-3 3.898E-2 2 24
42 1269847 APC-Cdc20 mediated degradation of Nek2A BioSystems: REACTOME 3.471E-4 1.008E-3 5.430E-3 4.235E-2 2 25
43 137959 BARD1 signaling events BioSystems: Pathway Interaction Database 4.686E-4 1.299E-3 6.996E-3
5.716E-2
 2 29
44 1269210 TAK1 activates NFkB by phosphorylation and activation of IKKs complex BioSystems: REACTOME 4.686E-4 1.299E-3 6.996E-3
5.716E-2
 2 29
45 1269252 NOD1/2 Signaling Pathway BioSystems: REACTOME 5.713E-4 1.549E-3 8.341E-3
6.970E-2
 2 32
46 1269298 Fc epsilon receptor (FCERI) signaling BioSystems: REACTOME 6.772E-4 1.776E-3 9.562E-3
8.262E-2
 4 381
47 137944 IL1-mediated signaling events BioSystems: Pathway Interaction Database 6.840E-4 1.776E-3 9.562E-3
8.345E-2
 2 35
48 167325 Protein processing in endoplasmic reticulum BioSystems: KEGG 7.605E-4 1.933E-3 1.041E-2
9.279E-2
 3 166
49 1309114 Formation of Incision Complex in GG-NER BioSystems: REACTOME 1.033E-3 2.571E-3 1.385E-2
1.260E-1
 2 43
50 1269527 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer BioSystems: REACTOME 1.181E-3 2.826E-3 1.522E-2
1.441E-1
 2 46
Show 45 more annotations

8: Pubmed [Display Chart] 14 input genes in category / 1671 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19549727 Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. Pubmed 3.294E-31 5.504E-28 4.402E-27 5.504E-28 13 147
2 20061386 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. Pubmed 2.920E-30 2.440E-27 1.952E-26 4.880E-27 10 26
3 24647965 Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity. Pubmed 5.489E-27 3.057E-24 2.445E-23 9.171E-24 9 24
4 26489670 New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins. Pubmed 6.498E-25 2.714E-22 2.171E-21 1.086E-21 8 17
5 27425610 Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity. Pubmed 2.020E-24 6.750E-22 5.399E-21 3.375E-21 8 19
6 17597759 Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging. Pubmed 2.888E-23 8.042E-21 6.433E-20 4.825E-20 8 25
7 19712108 Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination. Pubmed 4.815E-23 1.149E-20 9.193E-20 8.045E-20 7 11
8 21143188 Functional interactions between ubiquitin E2 enzymes and TRIM proteins. Pubmed 1.723E-19 3.598E-17 2.878E-16 2.879E-16 7 28
9 25527291 Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis. Pubmed 3.824E-19 7.100E-17 5.679E-16 6.390E-16 7 31
10 22069333 E1-E2 interactions in ubiquitin and Nedd8 ligation pathways. Pubmed 6.432E-19 8.957E-17 7.164E-16 1.075E-15 6 12
11 24905733 Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding. Pubmed 6.432E-19 8.957E-17 7.164E-16 1.075E-15 6 12
12 28763789 Ubiquitination of STING at lysine 224 controls IRF3 activation. Pubmed 6.432E-19 8.957E-17 7.164E-16 1.075E-15 6 12
13 27678051 Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination. Pubmed 1.774E-17 2.280E-15 1.824E-14 2.964E-14 5 6
14 21113135 c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. Pubmed 3.771E-17 4.501E-15 3.601E-14 6.302E-14 6 21
15 11714696 Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. Pubmed 6.207E-17 6.483E-15 5.185E-14 1.037E-13 5 7
16 20553626 RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand. Pubmed 6.207E-17 6.483E-15 5.185E-14 1.037E-13 5 7
17 16682404 A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control. Pubmed 1.655E-16 1.455E-14 1.164E-13 2.765E-13 5 8
18 24446487 E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis. Pubmed 1.655E-16 1.455E-14 1.164E-13 2.765E-13 5 8
19 18838541 Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation. Pubmed 1.655E-16 1.455E-14 1.164E-13 2.765E-13 5 8
20 26711259 Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181. Pubmed 3.723E-16 3.110E-14 2.488E-13 6.221E-13 5 9
21 20864041 MAGE-RING protein complexes comprise a family of E3 ubiquitin ligases. Pubmed 6.286E-16 5.002E-14 4.001E-13 1.050E-12 6 32
22 21518764 E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP. Pubmed 7.444E-16 5.654E-14 4.523E-13 1.244E-12 5 10
23 14690596 Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Pubmed 5.909E-15 4.293E-13 3.434E-12 9.874E-12 5 14
24 21965653 E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes. Pubmed 8.862E-15 5.924E-13 4.738E-12 1.481E-11 5 15
25 17588522 E3-independent monoubiquitination of ubiquitin-binding proteins. Pubmed 8.862E-15 5.924E-13 4.738E-12 1.481E-11 5 15
26 23695783 Comprehensive ubiquitin E2 profiling of ten ubiquitin E3 ligases. Pubmed 1.289E-14 8.283E-13 6.625E-12 2.154E-11 5 16
27 16413270 ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains. Pubmed 5.645E-14 3.369E-12 2.695E-11 9.433E-11 4 5
28 15684077 E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1). Pubmed 5.645E-14 3.369E-12 2.695E-11 9.433E-11 4 5
29 16549277 h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes. Pubmed 1.693E-13 8.321E-12 6.656E-11 2.829E-10 4 6
30 28625874 Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114. Pubmed 1.693E-13 8.321E-12 6.656E-11 2.829E-10 4 6
31 9990509 Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes. Pubmed 1.693E-13 8.321E-12 6.656E-11 2.829E-10 4 6
32 16337426 The ubiquitin-protein ligases Nedd4 and Nedd4-2 show similar ubiquitin-conjugating enzyme specificities. Pubmed 1.693E-13 8.321E-12 6.656E-11 2.829E-10 4 6
33 23131556 Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. Pubmed 1.693E-13 8.321E-12 6.656E-11 2.829E-10 4 6
34 15280377 Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo. Pubmed 1.693E-13 8.321E-12 6.656E-11 2.829E-10 4 6
35 20804422 Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays. Pubmed 3.468E-13 1.610E-11 1.288E-10 5.795E-10 6 87
36 17006537 A ubiquitin ligase complex assembles linear polyubiquitin chains. Pubmed 3.950E-13 1.610E-11 1.288E-10 6.600E-10 4 7
37 24831002 Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein. Pubmed 3.950E-13 1.610E-11 1.288E-10 6.600E-10 4 7
38 22350887 Measuring rates of ubiquitin chain formation as a functional readout of ligase activity. Pubmed 3.950E-13 1.610E-11 1.288E-10 6.600E-10 4 7
39 20051513 Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes. Pubmed 3.950E-13 1.610E-11 1.288E-10 6.600E-10 4 7
40 21694720 Autoregulation of Parkin activity through its ubiquitin-like domain. Pubmed 3.950E-13 1.610E-11 1.288E-10 6.600E-10 4 7
41 17719635 UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I. Pubmed 3.950E-13 1.610E-11 1.288E-10 6.600E-10 4 7
42 15247280 Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53. Pubmed 7.898E-13 2.869E-11 2.295E-10 1.320E-9 4 8
43 28972136 The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly. Pubmed 7.898E-13 2.869E-11 2.295E-10 1.320E-9 4 8
44 25207814 MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac. Pubmed 7.898E-13 2.869E-11 2.295E-10 1.320E-9 4 8
45 29323787 Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7. Pubmed 7.898E-13 2.869E-11 2.295E-10 1.320E-9 4 8
46 28681414 Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase. Pubmed 7.898E-13 2.869E-11 2.295E-10 1.320E-9 4 8
47 12525502 Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO. Pubmed 1.421E-12 5.053E-11 4.042E-10 2.375E-9 4 9
48 28757353 Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells. Pubmed 2.368E-12 8.245E-11 6.595E-10 3.958E-9 4 10
49 26752685 FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. Pubmed 5.350E-12 1.824E-10 1.459E-9 8.940E-9 6 136
50 20940148 The Machado-Joseph disease-associated mutant form of ataxin-3 regulates parkin ubiquitination and stability. Pubmed 5.580E-12 1.865E-10 1.492E-9 9.325E-9 4 12
Show 45 more annotations

9: Interaction [Display Chart] 14 input genes in category / 1386 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MKRN3 MKRN3 interactions 9.951E-20 1.379E-16 1.077E-15 1.379E-16 9 63
2 int:BIRC8 BIRC8 interactions 1.595E-18 9.810E-16 7.663E-15 2.210E-15 7 19
3 int:UBOX5 UBOX5 interactions 2.453E-18 9.810E-16 7.663E-15 3.399E-15 7 20
4 int:UBA1 UBA1 interactions 2.831E-18 9.810E-16 7.663E-15 3.924E-15 10 161
5 int:PRKN PRKN interactions 7.332E-18 2.032E-15 1.588E-14 1.016E-14 12 461
6 int:RNF11 RNF11 interactions 3.707E-17 6.472E-15 5.056E-14 5.138E-14 9 118
7 int:ZNRF1 ZNRF1 interactions 3.736E-17 6.472E-15 5.056E-14 5.178E-14 7 28
8 int:MARCH7 MARCH7 interactions 3.736E-17 6.472E-15 5.056E-14 5.178E-14 7 28
9 int:RNF111 RNF111 interactions 1.165E-16 1.794E-14 1.401E-13 1.614E-13 8 70
10 int:RNF103 RNF103 interactions 2.105E-16 2.917E-14 2.279E-13 2.917E-13 6 14
11 int:MID1 MID1 interactions 2.591E-16 3.264E-14 2.550E-13 3.591E-13 8 77
12 int:DTX3 DTX3 interactions 3.238E-16 3.740E-14 2.922E-13 4.488E-13 7 37
13 int:TRIM39 TRIM39 interactions 3.566E-16 3.802E-14 2.970E-13 4.942E-13 8 80
14 int:XIAP XIAP interactions 6.177E-16 6.115E-14 4.777E-13 8.561E-13 9 160
15 int:DZIP3 DZIP3 interactions 1.042E-15 9.628E-14 7.521E-13 1.444E-12 8 91
16 int:CNOT4 CNOT4 interactions 1.898E-15 1.644E-13 1.284E-12 2.630E-12 6 19
17 int:RNF5 RNF5 interactions 3.127E-15 2.550E-13 1.992E-12 4.335E-12 7 50
18 int:RNF167 RNF167 interactions 3.793E-15 2.920E-13 2.281E-12 5.257E-12 6 21
19 int:RC3H2 RC3H2 interactions 5.213E-15 3.613E-13 2.822E-12 7.225E-12 6 22
20 int:RNF125 RNF125 interactions 5.213E-15 3.613E-13 2.822E-12 7.225E-12 6 22
21 int:TRIM5 TRIM5 interactions 7.246E-15 4.783E-13 3.736E-12 1.004E-11 7 56
22 int:MUL1 MUL1 interactions 8.258E-15 5.203E-13 4.064E-12 1.145E-11 7 57
23 int:RNF165 RNF165 interactions 3.476E-14 2.008E-12 1.568E-11 4.818E-11 5 10
24 int:RNF122 RNF122 interactions 3.476E-14 2.008E-12 1.568E-11 4.818E-11 5 10
25 int:ARIH2 ARIH2 interactions 4.134E-14 2.292E-12 1.790E-11 5.729E-11 7 71
26 int:TRIM50 TRIM50 interactions 1.092E-13 5.819E-12 4.546E-11 1.513E-10 5 12
27 int:RNF14 RNF14 interactions 1.917E-13 9.840E-12 7.687E-11 2.657E-10 6 38
28 int:UBE2V1 UBE2V1 interactions 2.307E-13 1.142E-11 8.921E-11 3.198E-10 7 90
29 int:RNF10 RNF10 interactions 2.663E-13 1.233E-11 9.630E-11 3.691E-10 6 40
30 int:STUB1 STUB1 interactions 2.710E-13 1.233E-11 9.630E-11 3.757E-10 9 312
31 int:TRIM45 TRIM45 interactions 2.757E-13 1.233E-11 9.630E-11 3.821E-10 5 14
32 int:TRIM32 TRIM32 interactions 3.156E-13 1.367E-11 1.068E-10 4.375E-10 7 94
33 int:RNF150 RNF150 interactions 4.134E-13 1.736E-11 1.356E-10 5.730E-10 5 15
34 int:BFAR BFAR interactions 1.598E-12 6.328E-11 4.943E-10 2.215E-9 5 19
35 int:CADPS2 CADPS2 interactions 1.598E-12 6.328E-11 4.943E-10 2.215E-9 5 19
36 int:CHFR CHFR interactions 1.782E-12 6.862E-11 5.360E-10 2.470E-9 6 54
37 int:RNF114 RNF114 interactions 2.239E-12 8.386E-11 6.551E-10 3.103E-9 6 56
38 int:RNF43 RNF43 interactions 2.794E-12 1.019E-10 7.961E-10 3.873E-9 5 21
39 int:RNF25 RNF25 interactions 3.614E-12 1.285E-10 1.003E-9 5.010E-9 5 22
40 int:UBE2V2 UBE2V2 interactions 3.821E-12 1.292E-10 1.009E-9 5.296E-9 6 61
41 int:LRSAM1 LRSAM1 interactions 3.821E-12 1.292E-10 1.009E-9 5.296E-9 6 61
42 int:F12 F12 interactions 4.617E-12 1.454E-10 1.136E-9 6.398E-9 5 23
43 int:TRIM17 TRIM17 interactions 4.617E-12 1.454E-10 1.136E-9 6.398E-9 5 23
44 int:ZNRF2 ZNRF2 interactions 4.617E-12 1.454E-10 1.136E-9 6.398E-9 5 23
45 int:TRIM31 TRIM31 interactions 7.283E-12 2.243E-10 1.752E-9 1.009E-8 5 25
46 int:TRIM11 TRIM11 interactions 7.512E-12 2.263E-10 1.768E-9 1.041E-8 6 68
47 int:MAP3K1 MAP3K1 interactions 7.707E-12 2.273E-10 1.775E-9 1.068E-8 7 147
48 int:RNF8 RNF8 interactions 8.224E-12 2.375E-10 1.855E-9 1.140E-8 6 69
49 int:BIRC2 BIRC2 interactions 8.482E-12 2.399E-10 1.874E-9 1.176E-8 7 149
50 int:DTX1 DTX1 interactions 9.013E-12 2.498E-10 1.952E-9 1.249E-8 5 26
Show 45 more annotations

10: Cytoband [Display Chart] 14 input genes in category / 14 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8q11.21 8q11.21 5.239E-3 2.681E-2
8.716E-2
7.335E-2
 1 13
2 3p24.2 3p24.2 7.648E-3 2.681E-2
8.716E-2
1.071E-1
 1 19
3 2p22.3 2p22.3 7.648E-3 2.681E-2
8.716E-2
1.071E-1
 1 19
4 10q21.1 10q21.1 8.450E-3 2.681E-2
8.716E-2
1.183E-1
 1 21
5 5q31.2 5q31.2 1.165E-2 2.681E-2
8.716E-2
1.631E-1
 1 29
6 20q13.2 20q13.2 1.165E-2 2.681E-2
8.716E-2
1.631E-1
 1 29
7 4q24 4q24 1.405E-2 2.681E-2
8.716E-2
1.967E-1
 1 35
8 12q22 12q22 1.683E-2 2.681E-2
8.716E-2
2.357E-1
 1 42
9 4p14 4p14 1.723E-2 2.681E-2
8.716E-2
2.412E-1
 1 43
10 Xq24 Xq24 2.555E-2 3.302E-2
1.074E-1
3.577E-1
 1 64
11 5q31.1 5q31.1 2.594E-2 3.302E-2
1.074E-1
3.632E-1
 1 65
12 17q25.1 17q25.1 3.301E-2 3.808E-2
1.238E-1
4.622E-1
 1 83
13 19q13.43 19q13.43 3.536E-2 3.808E-2
1.238E-1
4.951E-1
 1 89
14 22q11.21 22q11.21 4.817E-2 4.817E-2
1.566E-1
6.744E-1
 1 122
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 13 input genes in category / 150 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ATCMNTCCGY UNKNOWN ATCMNTCCGY UNKNOWN 1.906E-5 2.858E-3 1.598E-2 2.858E-3 3 41

12: Gene Family [Display Chart] 13 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 102 Ubiquitin conjugating enzymes E2 genenames.org 4.603E-36 9.207E-36 1.381E-35 9.207E-36 13 41
2 419 Ring finger proteins|Baculoviral IAP repeat containing|Caspase recruitment domain containing genenames.org 5.703E-3 5.703E-3 8.554E-3 1.141E-2 1 8

13: Coexpression [Display Chart] 14 input genes in category / 1177 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19074895-Table3 Human Liver Sakai08 86genes GeneSigDB 1.818E-14 1.168E-11 8.934E-11 2.140E-11 7 82
2 M9224 Selected genes up-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.985E-14 1.168E-11 8.934E-11 2.336E-11 7 83
3 M11563 Genes involved in DNA repair, compiled manually by the authors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.832E-11 1.111E-8 8.498E-8 3.333E-8 7 230
4 M10236 Genes up-regulated in biphasic (mixed) vs epithelial subtypes of malignant peritoneal mesothelioma. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.996E-7 2.059E-4 1.575E-3 8.235E-4 5 305
5 19096012-TableS2 Human Viral Chetaille09 501genes GeneSigDB 4.179E-6 9.836E-4 7.523E-3 4.918E-3 5 439
6 19286929-SuppTable2g Mouse Lung Rangasamy09 78genes GeneSigDB 9.838E-6 1.930E-3 1.476E-2 1.158E-2 3 71
7 20418243-SuppTable1a Human Leukemia Chiaretti10 405genes GeneSigDB 3.067E-5 4.962E-3 3.795E-2 3.610E-2 4 316
8 15670303-Table1 Human Viral Ahn05 157genes GeneSigDB 3.373E-5 4.962E-3 3.795E-2 3.970E-2 3 107
9 15632314-Table1b Human Leukemia Takagaki04 30genes DownRegulated GeneSigDB 1.274E-4 1.412E-2
1.080E-1
1.499E-1
 2 28
10 M8520 Cluster 6 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts poor survival outcome. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.274E-4 1.412E-2
1.080E-1
1.500E-1
 4 456
11 M6579 Genes up-regulated in ITGAM+ [GeneID=3684] cells from spleens of tumor bearing mice: processed immediately versus those incubated for 24h in complete medium. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
12 M3823 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 0.5 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
13 M3960 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
14 M3973 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 8 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
15 M4601 Genes up-regulated in comparison of CD25+ T cells treated with IL4 [GeneID=3565] versus CD25- T cells treated with IL4 [GeneID=3565] at day 5. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
16 M5990 Genes up-regulated in macrophages: wildtype versus SOCS3 [GeneID=9021]. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
17 M4589 Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 5. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
18 M5171 Genes down-regulated in comparison of macrophages versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 1.412E-2
1.080E-1
2.541E-1
 3 200
19 M16036 Genes up-regulated in metastatic tumors from the whole panel of patients with prostate cancer. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.781E-4 1.723E-2
1.318E-1
3.274E-1
 3 218
20 16166288-Table4 Human Bone Man05 45genes GeneSigDB 3.027E-4 1.781E-2
1.362E-1
3.563E-1
 2 43
21 M6562 Genes up-regulated by 2-methoxyestradiol (2ME2) [PubChem=1573] in the MM.1S cell line (multiple myeloma) sensitive to dexamethasone [PubChem=5743]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.262E-4 2.389E-2
1.827E-1
5.017E-1
 2 51
22 M15123 Genes down-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.257E-4 2.813E-2
2.151E-1
6.188E-1
 3 271
23 M16975 Up-regulated genes in peripheral zone of human pancreatic cancer growing in the pancreas of nude mice compared to that of the tumor from the central zone. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.026E-4 3.084E-2
2.358E-1
7.092E-1
 3 284
24 19252174-Table3 Human Leukemia Hernandez09 66genes GeneSigDB 6.920E-4 3.393E-2
2.595E-1
8.144E-1
 2 65
25 15492233-TableS1 Human Sarcoma Lee04 335genes GeneSigDB 8.140E-4 3.832E-2
2.931E-1
9.581E-1
 3 315
26 M4479 Genes up-regulated in ductal carcinoma vs normal lobular breast cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.718E-4 3.947E-2
3.019E-1
1.000E0
 2 73
27 15492233-TableS3 Human Sarcoma Lee04 80genes GeneSigDB 9.445E-4 4.117E-2
3.149E-1
1.000E0
 2 76
Show 22 more annotations

14: Coexpression Atlas [Display Chart] 14 input genes in category / 418 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 13 input genes in category / 100 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M19318 MODULE 4 Genes in the cancer module 4. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.058E-29 1.058E-27 5.490E-27 1.058E-27 11 21
2 M16146 MODULE 82 Genes in the cancer module 82. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.486E-29 3.743E-27 1.942E-26 7.486E-27 11 24
3 M18951 MODULE 233 Genes in the cancer module 233. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.476E-26 2.159E-24 1.120E-23 6.476E-24 10 22
4 M150 MODULE 278 Ubiquitin ligases. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.309E-20 3.273E-19 1.698E-18 1.309E-18 9 34
5 M4414 MODULE 91 Proteasome. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.005E-3 2.011E-2
1.043E-1
1.005E-1
 2 37
6 M446 MORF HAT1 Neighborhood of HAT1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.289E-3 2.148E-2
1.114E-1
1.289E-1
 3 174
Show 1 more annotation

16: MicroRNA [Display Chart] 14 input genes in category / 841 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-641:PITA hsa-miR-641:PITA TOP PITA 2.709E-10 2.278E-7 1.666E-6 2.278E-7 6 490
2 hsa-miR-380:PITA hsa-miR-380:PITA TOP PITA 9.513E-9 4.000E-6 2.925E-5 8.000E-6 5 398
3 hsa-miR-499-5p:PITA hsa-miR-499-5p:PITA TOP PITA 8.791E-8 2.464E-5 1.802E-4 7.393E-5 4 224
4 GTACTGT,MIR-101:MSigDB GTACTGT,MIR-101:MSigDB MSigDB 1.198E-7 2.518E-5 1.841E-4 1.007E-4 4 242
5 ATAACCT,MIR-154:MSigDB ATAACCT,MIR-154:MSigDB MSigDB 1.596E-7 2.685E-5 1.963E-4 1.342E-4 3 56
6 AGTCTTA,MIR-499:MSigDB AGTCTTA,MIR-499:MSigDB MSigDB 3.285E-7 4.605E-5 3.367E-4 2.763E-4 3 71
7 hsa-miR-486-5p:mirSVR highEffct hsa-miR-486-5p:mirSVR conserved highEffect-0.5 MicroRNA.org 1.378E-6 1.656E-4 1.211E-3 1.159E-3 4 447
8 hsa-miR-101:PITA hsa-miR-101:PITA TOP PITA 1.813E-6 1.906E-4 1.393E-3 1.525E-3 4 479
9 hsa-miR-532-3p:PITA hsa-miR-532-3p:PITA TOP PITA 3.602E-6 3.365E-4 2.461E-3 3.029E-3 3 157
10 hsa-miR-208b:mirSVR highEffct hsa-miR-208b:mirSVR conserved highEffect-0.5 MicroRNA.org 6.281E-6 4.885E-4 3.572E-3 5.282E-3 3 189
11 hsa-miR-154:PITA hsa-miR-154:PITA TOP PITA 7.003E-6 4.885E-4 3.572E-3 5.890E-3 3 196
12 hsa-miR-1183:PITA hsa-miR-1183:PITA TOP PITA 7.219E-6 4.885E-4 3.572E-3 6.071E-3 3 198
13 hsa-miR-1321:PITA hsa-miR-1321:PITA TOP PITA 7.551E-6 4.885E-4 3.572E-3 6.351E-3 3 201
14 hsa-miR-649:PITA hsa-miR-649:PITA TOP PITA 8.981E-6 5.395E-4 3.945E-3 7.553E-3 3 213
15 hsa-miR-1301:PITA hsa-miR-1301:PITA TOP PITA 1.667E-5 9.344E-4 6.833E-3 1.402E-2 3 262
16 hsa-miR-409-3p:PITA hsa-miR-409-3p:PITA TOP PITA 2.349E-5 1.210E-3 8.847E-3 1.976E-2 3 294
17 hsa-miR-376c:PITA hsa-miR-376c:PITA TOP PITA 2.446E-5 1.210E-3 8.847E-3 2.057E-2 3 298
18 hsa-miR-653:PITA hsa-miR-653:PITA TOP PITA 2.646E-5 1.236E-3 9.041E-3 2.225E-2 3 306
19 hsa-miR-515-5p:PITA hsa-miR-515-5p:PITA TOP PITA 2.939E-5 1.301E-3 9.514E-3 2.472E-2 3 317
20 hsa-miR-500:PITA hsa-miR-500:PITA TOP PITA 3.165E-5 1.331E-3 9.733E-3 2.662E-2 3 325
21 hsa-miR-501-5p:PITA hsa-miR-501-5p:PITA TOP PITA 3.619E-5 1.449E-3 1.060E-2 3.044E-2 3 340
22 hsa-miR-4274:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.080E-5 1.496E-3 1.094E-2 3.431E-2 2 49
23 hsa-miR-216a:PITA hsa-miR-216a:PITA TOP PITA 4.396E-5 1.496E-3 1.094E-2 3.697E-2 3 363
24 hsa-miR-1273d:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.599E-5 1.496E-3 1.094E-2 3.868E-2 2 52
25 TTGCACT,MIR-130A:MSigDB TTGCACT,MIR-130A:MSigDB MSigDB 4.803E-5 1.496E-3 1.094E-2 4.039E-2 3 374
26 TTGCACT,MIR-301:MSigDB TTGCACT,MIR-301:MSigDB MSigDB 4.803E-5 1.496E-3 1.094E-2 4.039E-2 3 374
27 TTGCACT,MIR-130B:MSigDB TTGCACT,MIR-130B:MSigDB MSigDB 4.803E-5 1.496E-3 1.094E-2 4.039E-2 3 374
28 hsa-miR-101-3p:Functional MTI Functional MTI miRTarbase 5.562E-5 1.595E-3 1.166E-2 4.678E-2 3 393
29 AATGTGA,MIR-23A:MSigDB AATGTGA,MIR-23A:MSigDB MSigDB 5.689E-5 1.595E-3 1.166E-2 4.785E-2 3 396
30 AATGTGA,MIR-23B:MSigDB AATGTGA,MIR-23B:MSigDB MSigDB 5.689E-5 1.595E-3 1.166E-2 4.785E-2 3 396
31 hsa-miR-609:PITA hsa-miR-609:PITA TOP PITA 6.983E-5 1.894E-3 1.385E-2
5.872E-2
 2 64
32 hsa-miR-744-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.564E-5 1.988E-3 1.454E-2
6.361E-2
 3 436
33 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 7.876E-5 2.007E-3 1.468E-2
6.623E-2
 3 442
34 hsa-miR-1264:PITA hsa-miR-1264:PITA TOP PITA 8.469E-5 2.095E-3 1.532E-2
7.123E-2
 3 453
35 hsa-miR-3607-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.845E-5 2.125E-3 1.554E-2
7.439E-2
 2 72
36 hsa-miR-653-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.858E-5 2.303E-3 1.684E-2
8.291E-2
 2 76
37 hsa-miR-376b-3p:Non-Functional MTI Non-Functional MTI miRTarbase 1.205E-4 2.738E-3 2.002E-2
1.013E-1
 2 84
38 hsa-miR-4330:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.445E-4 3.039E-3 2.222E-2
1.216E-1
 2 92
39 hsa-miR-4519:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.445E-4 3.039E-3 2.222E-2
1.216E-1
 2 92
40 hsa-miR-571:PITA hsa-miR-571:PITA TOP PITA 1.445E-4 3.039E-3 2.222E-2
1.216E-1
 2 92
41 ATTACAT,MIR-380-3P:MSigDB ATTACAT,MIR-380-3P:MSigDB MSigDB 1.674E-4 3.273E-3 2.394E-2
1.408E-1
 2 99
42 hsa-miR-617:PITA hsa-miR-617:PITA TOP PITA 1.674E-4 3.273E-3 2.394E-2
1.408E-1
 2 99
43 hsa-miR-2114-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.674E-4 3.273E-3 2.394E-2
1.408E-1
 2 99
44 AGGAAGC,MIR-516-3P:MSigDB AGGAAGC,MIR-516-3P:MSigDB MSigDB 1.919E-4 3.574E-3 2.613E-2
1.614E-1
 2 106
45 hsa-miR-5588-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.919E-4 3.574E-3 2.613E-2
1.614E-1
 2 106
46 hsa-miR-3174:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.955E-4 3.574E-3 2.613E-2
1.644E-1
 2 107
47 hsa-miR-376a-3p:Non-Functional MTI Non-Functional MTI miRTarbase 2.142E-4 3.832E-3 2.802E-2
1.801E-1
 2 112
48 hsa-miR-5093:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.377E-4 4.164E-3 3.045E-2
1.999E-1
 2 118
49 hsa-miR-4694-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.458E-4 4.218E-3 3.085E-2
2.067E-1
 2 120
50 hsa-miR-6515-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.795E-4 4.586E-3 3.354E-2
2.351E-1
 2 128
Show 45 more annotations

17: Drug [Display Chart] 14 input genes in category / 1354 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C017906 3-dinitrobenzene CTD 1.242E-9 1.681E-6 1.309E-5 1.681E-6 7 390
2 ctd:D010695 Phlorhizin CTD 3.119E-9 2.112E-6 1.645E-5 4.223E-6 6 235
3 CID000005569 trifluralin Stitch 9.894E-7 4.465E-4 3.478E-3 1.340E-3 4 131
4 CID000069736 6-hydroxymethylpterin Stitch 1.407E-6 4.762E-4 3.709E-3 1.905E-3 3 37
5 CID006420160 2f34 Stitch 4.172E-6 1.130E-3 8.799E-3 5.649E-3 4 188
6 CID000380957 NSC666740 Stitch 1.253E-5 2.827E-3 2.202E-2 1.696E-2 2 9
7 CID000004156 methyl methanesulfonate Stitch 5.597E-5 1.083E-2
8.431E-2
7.578E-2
 4 364
8 ctd:D015647 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine CTD 1.226E-4 2.075E-2
1.616E-1
1.660E-1
 3 163
9 1065 DN LY 294002; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.898E-4 2.640E-2
2.056E-1
2.570E-1
 3 189
10 7098 UP 0316684-0000 [391209-55-5]; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.019E-4 2.640E-2
2.056E-1
2.733E-1
 3 193
11 1725 DN Mesoridazine besylate [32672-69-8]; Down 200; 7.4uM; HL60; HG-U133A Broad Institute CMAP Down 2.144E-4 2.640E-2
2.056E-1
2.903E-1
 3 197
12 CID000009074 TK-B Stitch 4.372E-4 4.734E-2
3.687E-1
5.920E-1
 2 51
13 CID000002537 Camphor Stitch 4.546E-4 4.734E-2
3.687E-1
6.155E-1
 2 52
Show 8 more annotations

18: Disease [Display Chart] 11 input genes in category / 149 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1868675 PARKINSON DISEASE 2, AUTOSOMAL RECESSIVE JUVENILE DisGeNET Curated 1.568E-4 2.337E-2
1.305E-1
 2.337E-2 2 28
2 cv:C3275464 X-linked syndromic mental retardation, Nascimento type Clinical Variations 6.788E-4 2.529E-2
1.412E-1
1.011E-1
 1 1
3 C3275464 MENTAL RETARDATION, X-LINKED, SYNDROMIC, NASCIMENTO TYPE DisGeNET Curated 6.788E-4 2.529E-2
1.412E-1
1.011E-1
 1 1
4 C4023402 Regional abnormality of skin DisGeNET Curated 6.788E-4 2.529E-2
1.412E-1
1.011E-1
 1 1