|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
3427074
|
Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.
|
Pubmed
|
1.777E-11
|
4.409E-8
|
3.701E-7
|
4.409E-8
|
3
|
3
|
2
|
27358403
|
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
|
Pubmed
|
1.777E-10
|
2.204E-7
|
1.850E-6
|
4.408E-7
|
3
|
5
|
3
|
24793170
|
Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.
|
Pubmed
|
2.929E-9
|
2.422E-6
|
2.033E-5
|
7.266E-6
|
3
|
11
|
4
|
25195861
|
The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
5
|
27999401
|
Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
6
|
2826474
|
Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
7
|
18799464
|
Elafin, an elastase-specific inhibitor, is cleaved by its cognate enzyme neutrophil elastase in sputum from individuals with cystic fibrosis.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
8
|
16327289
|
Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
9
|
8794736
|
Crystal structure of an elastase-specific inhibitor elafin complexed with porcine pancreatic elastase determined at 1.9 A resolution.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
10
|
19197381
|
Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
11
|
2460440
|
Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
12
|
28187039
|
Plasma Neutrophil Elastase and Elafin as Prognostic Biomarker for Acute Respiratory Distress Syndrome: A Multicenter Survival and Longitudinal Prospective Observation Study.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
13
|
3646943
|
Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.
|
Pubmed
|
7.541E-8
|
1.439E-5
|
1.208E-4
|
1.871E-4
|
2
|
2
|
14
|
8864963
|
Functional and metabolic differences between elastase-generated fragments of human lipoprotein[a] and apolipoprotein[a].
|
Pubmed
|
2.262E-7
|
3.507E-5
|
2.944E-4
|
5.612E-4
|
2
|
3
|
15
|
1079736
|
The interaction of alpha-1-antitrypsin with chymotrypsin, trypsin and elastase.
|
Pubmed
|
2.262E-7
|
3.507E-5
|
2.944E-4
|
5.612E-4
|
2
|
3
|
16
|
9111002
|
Polymorphonuclear cells isolated from human peripheral blood cleave lipoprotein(a) and apolipoprotein(a) at multiple interkringle sites via the enzyme elastase. Generation of mini-Lp(a) particles and apo(a) fragments.
|
Pubmed
|
2.262E-7
|
3.507E-5
|
2.944E-4
|
5.612E-4
|
2
|
3
|
17
|
6153632
|
Interaction between human pancreatic elastase and plasma protease inhibitors.
|
Pubmed
|
4.523E-7
|
5.906E-5
|
4.958E-4
|
1.122E-3
|
2
|
4
|
18
|
20179351
|
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.
|
Pubmed
|
4.523E-7
|
5.906E-5
|
4.958E-4
|
1.122E-3
|
2
|
4
|
19
|
6191979
|
Radioimmunoassay of human pancreatic elastase 1. In vitro interaction of human pancreatic elastase 1 with serum protease inhibitors.
|
Pubmed
|
4.523E-7
|
5.906E-5
|
4.958E-4
|
1.122E-3
|
2
|
4
|
20
|
12189154
|
Characterization of four murine homologs of the human ov-serpin monocyte neutrophil elastase inhibitor MNEI (SERPINB1).
|
Pubmed
|
7.538E-7
|
9.350E-5
|
7.849E-4
|
1.870E-3
|
2
|
5
|
21
|
11961105
|
Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop.
|
Pubmed
|
1.130E-6
|
1.336E-4
|
1.121E-3
|
2.805E-3
|
2
|
6
|
22
|
20346360
|
Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease.
|
Pubmed
|
2.348E-6
|
2.648E-4
|
2.223E-3
|
5.826E-3
|
3
|
94
|
23
|
9851981
|
The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.
|
Pubmed
|
4.142E-6
|
4.468E-4
|
3.750E-3
|
1.028E-2
|
2
|
11
|
24
|
16518820
|
Osteopontin is a novel marker of pancreatic ductal tissues and of undifferentiated pancreatic precursors in mice.
|
Pubmed
|
9.029E-6
|
4.664E-4
|
3.915E-3
|
2.240E-2
|
2
|
16
|
25
|
28071719
|
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
|
Pubmed
|
1.098E-5
|
4.664E-4
|
3.915E-3
|
2.723E-2
|
3
|
157
|
26
|
25063451
|
The nuclear hormone receptor family member NR5A2 controls aspects of multipotent progenitor cell formation and acinar differentiation during pancreatic organogenesis.
|
Pubmed
|
3.266E-5
|
4.664E-4
|
3.915E-3
|
8.103E-2
|
2
|
30
|
27
|
15694261
|
Normal brain mitochondrial respiration in adult mice lacking cellular prion protein.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
28
|
28827331
|
Prion protein
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
29
|
15266305
|
Polymorphisms of the PRNP gene in Chinese populations and the identification of a novel insertion mutation.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
30
|
19820689
|
Diagnostic utility of SALL4 in primary germ cell tumors of the central nervous system: a study of 77 cases.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
31
|
12386336
|
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
32
|
10679935
|
Transgenic rescue of aganglionosis and piebaldism in lethal spotted mice.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
33
|
1687385
|
The scrapie fibril protein and its cellular isoform.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
34
|
21478678
|
Silencing of cellular prion protein (PrPC) expression by DNA-antisense oligonucleotides induces autophagy-dependent cell death in glioma cells.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
35
|
8575772
|
Physical mapping of the human ELA1 gene between D12S361 and D12S347 on chromosome 12q13.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
36
|
14610121
|
Surgical outcome in mesial temporal sclerosis correlates with prion protein gene variant.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
37
|
22669942
|
Multiple substitutions of methionine 129 in human prion protein reveal its importance in the amyloid fibrillation pathway.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
38
|
11704923
|
Sporadic--but not variant--Creutzfeldt-Jakob disease is associated with polymorphisms upstream of PRNP exon 1.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
39
|
10790216
|
Identification of three novel mutations (E196K, V203I, E211Q) in the prion protein gene (PRNP) in inherited prion diseases with Creutzfeldt-Jakob disease phenotype.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
40
|
21350487
|
Prion propagation and toxicity in vivo occur in two distinct mechanistic phases.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
41
|
16921242
|
Autopsy-proven Creutzfeldt-Jakob disease with a codon 180 mutation showing dissociation between diffusion-weighted magnetic resonance imaging and single-photon emission computed tomography findings: Is this a suggestive finding in long survival?
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
42
|
14657385
|
NMR-detected hydrogen exchange and molecular dynamics simulations provide structural insight into fibril formation of prion protein fragment 106-126.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
43
|
15941909
|
Motility, proliferation, and egress to the circulation of human AML cells are elastase dependent in NOD/SCID chimeric mice.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
44
|
22032174
|
Long-time scale fluctuations of human prion protein determined by restrained MD simulations.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
45
|
20932979
|
Pathogenic mutations in the hydrophobic core of the human prion protein can promote structural instability and misfolding.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
46
|
20921524
|
Neutrophil elastase mediates pathogenic effects of anthrax lethal toxin in the murine intestinal tract.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
47
|
17923484
|
High titers of transmissible spongiform encephalopathy infectivity associated with extremely low levels of PrPSc in vivo.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
48
|
20453918
|
CSPalpha: the neuroprotective J protein.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
49
|
21597335
|
A Chinese Creutzfeldt-Jakob disease patient with E196K mutation in PRNP.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|
50
|
26932165
|
Protective effects of elafin against adult asthma.
|
Pubmed
|
2.880E-4
|
4.664E-4
|
3.915E-3
|
7.146E-1
|
1
|
1
|