Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc162_17, positive side

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1: GO: Molecular Function [Display Chart] 17 input genes in category / 90 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity 3.001E-24 2.701E-22 1.373E-21 2.701E-22 8 10
2 GO:0046332 SMAD binding 3.397E-23 1.529E-21 7.770E-21 3.058E-21 11 77
3 GO:0070411 I-SMAD binding 9.732E-17 2.920E-15 1.484E-14 8.759E-15 6 11
4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity 3.283E-16 7.387E-15 3.755E-14 2.955E-14 5 5
5 GO:0070412 R-SMAD binding 2.817E-14 5.070E-13 2.577E-12 2.535E-12 6 24
6 GO:0048185 activin binding 4.207E-13 6.311E-12 3.208E-11 3.787E-11 5 13
7 GO:0017002 activin-activated receptor activity 1.646E-11 2.117E-10 1.076E-9 1.482E-9 4 7
8 GO:0070410 co-SMAD binding 2.322E-10 2.612E-9 1.328E-8 2.090E-8 4 12
9 GO:0016361 activin receptor activity, type I 2.510E-9 2.510E-8 1.276E-7 2.259E-7 3 4
10 GO:0004675 transmembrane receptor protein serine/threonine kinase activity 4.951E-9 4.456E-8 2.265E-7 4.456E-7 4 24
11 GO:0034713 type I transforming growth factor beta receptor binding 7.506E-8 6.141E-7 3.121E-6 6.755E-6 3 10
12 GO:0031625 ubiquitin protein ligase binding 1.003E-7 7.524E-7 3.824E-6 9.028E-6 6 273
13 GO:0044389 ubiquitin-like protein ligase binding 1.093E-7 7.569E-7 3.847E-6 9.840E-6 6 277
14 GO:0005160 transforming growth factor beta receptor binding 1.343E-7 8.631E-7 4.387E-6 1.208E-5 4 53
15 GO:0030617 transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity 7.811E-7 4.687E-6 2.382E-5 7.030E-5 2 2
16 GO:0019199 transmembrane receptor protein kinase activity 1.200E-6 6.748E-6 3.430E-5 1.080E-4 4 91
17 GO:0019838 growth factor binding 7.082E-6 3.749E-5 1.906E-4 6.374E-4 4 142
18 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 1.276E-5 6.380E-5 3.243E-4 1.148E-3 5 357
19 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 1.703E-5 8.067E-5 4.100E-4 1.533E-3 5 379
20 GO:0000987 proximal promoter sequence-specific DNA binding 2.155E-5 9.699E-5 4.930E-4 1.940E-3 5 398
21 GO:0005518 collagen binding 3.602E-5 1.544E-4 7.847E-4 3.242E-3 3 72
22 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 7.484E-5 3.062E-4 1.556E-3 6.736E-3 4 259
23 GO:0005126 cytokine receptor binding 1.144E-4 4.475E-4 2.275E-3 1.029E-2 4 289
24 GO:0070696 transmembrane receptor protein serine/threonine kinase binding 1.324E-4 4.964E-4 2.523E-3 1.191E-2 2 19
25 GO:0033612 receptor serine/threonine kinase binding 1.470E-4 5.292E-4 2.690E-3 1.323E-2 2 20
26 GO:0001085 RNA polymerase II transcription factor binding 1.571E-4 5.438E-4 2.764E-3 1.414E-2 3 118
27 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 2.801E-4 9.335E-4 4.745E-3 2.520E-2 4 365
28 GO:0004674 protein serine/threonine kinase activity 6.292E-4 2.022E-3 1.028E-2
5.662E-2
 4 452
29 GO:0030616 transforming growth factor beta receptor, common-partner cytoplasmic mediator activity 9.110E-4 2.827E-3 1.437E-2
8.199E-2
 1 1
30 GO:0033613 activating transcription factor binding 1.385E-3 4.155E-3 2.112E-2
1.246E-1
 2 61
31 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 1.619E-3 4.700E-3 2.389E-2
1.457E-1
 2 66
32 GO:0070698 type I activin receptor binding 2.731E-3 7.447E-3 3.785E-2
2.458E-1
 1 3
33 GO:0016362 activin receptor activity, type II 2.731E-3 7.447E-3 3.785E-2
2.458E-1
 1 3
34 GO:0008013 beta-catenin binding 2.920E-3 7.729E-3 3.928E-2
2.628E-1
 2 89
35 GO:0005025 transforming growth factor beta receptor activity, type I 3.639E-3 9.358E-3 4.756E-2
3.275E-1
 1 4
36 GO:0019955 cytokine binding 3.887E-3 9.718E-3 4.939E-2
3.499E-1
 2 103
37 GO:0035326 enhancer binding 4.112E-3 1.000E-2
5.083E-2
3.700E-1
 2 106
38 GO:0098821 BMP receptor activity 4.547E-3 1.023E-2
5.200E-2
4.092E-1
 1 5
39 GO:0038100 nodal binding 4.547E-3 1.023E-2
5.200E-2
4.092E-1
 1 5
40 GO:0070878 primary miRNA binding 4.547E-3 1.023E-2
5.200E-2
4.092E-1
 1 5
41 GO:0001046 core promoter sequence-specific DNA binding 4.820E-3 1.058E-2
5.377E-2
4.338E-1
 2 115
42 GO:0034711 inhibin binding 6.361E-3 1.363E-2
6.927E-2
5.724E-1
 1 7
43 GO:0070697 activin receptor binding 7.266E-3 1.521E-2
7.730E-2
6.539E-1
 1 8
44 GO:0005024 transforming growth factor beta-activated receptor activity 9.075E-3 1.856E-2
9.434E-2
8.167E-1
 1 10
45 GO:0001047 core promoter binding 9.574E-3 1.911E-2
9.711E-2
8.617E-1
 2 164
46 GO:0036122 BMP binding 9.978E-3 1.911E-2
9.711E-2
8.980E-1
 1 11
47 GO:0070700 BMP receptor binding 9.978E-3 1.911E-2
9.711E-2
8.980E-1
 1 11
48 GO:0019902 phosphatase binding 1.231E-2 2.307E-2
1.173E-1
1.000E0
 2 187
49 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding 1.268E-2 2.330E-2
1.184E-1
1.000E0
 1 14
50 GO:0031005 filamin binding 1.448E-2 2.607E-2
1.325E-1
1.000E0
 1 16
Show 45 more annotations

2: GO: Biological Process [Display Chart] 17 input genes in category / 992 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway 2.568E-22 2.548E-19 1.905E-18 2.548E-19 14 343
2 GO:0007179 transforming growth factor beta receptor signaling pathway 3.569E-21 1.770E-18 1.324E-17 3.541E-18 12 184
3 GO:0071560 cellular response to transforming growth factor beta stimulus 5.532E-20 1.608E-17 1.202E-16 5.488E-17 12 230
4 GO:0071559 response to transforming growth factor beta 6.482E-20 1.608E-17 1.202E-16 6.431E-17 12 233
5 GO:0030509 BMP signaling pathway 1.683E-17 3.338E-15 2.496E-14 1.669E-14 10 151
6 GO:0071772 response to BMP 3.921E-17 5.556E-15 4.155E-14 3.889E-14 10 164
7 GO:0071773 cellular response to BMP stimulus 3.921E-17 5.556E-15 4.155E-14 3.889E-14 10 164
8 GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 8.551E-16 1.060E-13 7.928E-13 8.482E-13 10 222
9 GO:0032924 activin receptor signaling pathway 7.796E-15 8.593E-13 6.425E-12 7.734E-12 7 47
10 GO:0001657 ureteric bud development 1.814E-14 1.622E-12 1.213E-11 1.800E-11 8 105
11 GO:0072163 mesonephric epithelium development 1.962E-14 1.622E-12 1.213E-11 1.946E-11 8 106
12 GO:0072164 mesonephric tubule development 1.962E-14 1.622E-12 1.213E-11 1.946E-11 8 106
13 GO:0001823 mesonephros development 2.660E-14 2.030E-12 1.518E-11 2.639E-11 8 110
14 GO:0001655 urogenital system development 9.650E-14 6.838E-12 5.113E-11 9.573E-11 10 355
15 GO:0072073 kidney epithelium development 3.008E-13 1.990E-11 1.488E-10 2.984E-10 8 148
16 GO:0007183 SMAD protein complex assembly 6.608E-13 4.097E-11 3.064E-10 6.555E-10 5 14
17 GO:0072001 renal system development 1.836E-12 1.072E-10 8.013E-10 1.822E-9 9 309
18 GO:0007389 pattern specification process 2.648E-12 1.362E-10 1.018E-9 2.627E-9 10 495
19 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway 2.745E-12 1.362E-10 1.018E-9 2.723E-9 7 105
20 GO:1903844 regulation of cellular response to transforming growth factor beta stimulus 2.745E-12 1.362E-10 1.018E-9 2.723E-9 7 105
21 GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.829E-12 1.809E-10 1.353E-9 3.798E-9 7 110
22 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation 1.154E-11 5.205E-10 3.892E-9 1.145E-8 6 61
23 GO:0060395 SMAD protein signal transduction 1.411E-11 6.086E-10 4.551E-9 1.400E-8 6 63
24 GO:0060389 pathway-restricted SMAD protein phosphorylation 1.556E-11 6.433E-10 4.810E-9 1.544E-8 6 64
25 GO:0007498 mesoderm development 2.025E-11 7.892E-10 5.901E-9 2.009E-8 7 139
26 GO:0009880 embryonic pattern specification 2.068E-11 7.892E-10 5.901E-9 2.052E-8 6 67
27 GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus 2.482E-11 8.542E-10 6.387E-9 2.462E-8 6 69
28 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway 2.482E-11 8.542E-10 6.387E-9 2.462E-8 6 69
29 GO:0090287 regulation of cellular response to growth factor stimulus 2.497E-11 8.542E-10 6.387E-9 2.477E-8 8 256
30 GO:0001822 kidney development 6.948E-11 2.298E-9 1.718E-8 6.893E-8 8 291
31 GO:0030510 regulation of BMP signaling pathway 1.036E-10 3.315E-9 2.479E-8 1.028E-7 6 87
32 GO:0090288 negative regulation of cellular response to growth factor stimulus 1.504E-9 4.663E-8 3.486E-7 1.492E-6 6 135
33 GO:0038092 nodal signaling pathway 2.281E-9 6.857E-8 5.127E-7 2.263E-6 4 20
34 GO:0001707 mesoderm formation 4.803E-9 1.401E-7 1.048E-6 4.765E-6 5 73
35 GO:0048332 mesoderm morphogenesis 6.304E-9 1.787E-7 1.336E-6 6.254E-6 5 77
36 GO:0032925 regulation of activin receptor signaling pathway 8.230E-9 2.268E-7 1.696E-6 8.165E-6 4 27
37 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus 9.597E-9 2.573E-7 1.924E-6 9.520E-6 4 28
38 GO:0014031 mesenchymal cell development 1.034E-8 2.700E-7 2.019E-6 1.026E-5 6 186
39 GO:0048864 stem cell development 1.251E-8 3.102E-7 2.319E-6 1.241E-5 6 192
40 GO:0007369 gastrulation 1.251E-8 3.102E-7 2.319E-6 1.241E-5 6 192
41 GO:0048762 mesenchymal cell differentiation 1.596E-8 3.862E-7 2.888E-6 1.583E-5 6 200
42 GO:0003002 regionalization 1.892E-8 4.393E-7 3.285E-6 1.877E-5 7 370
43 GO:0030278 regulation of ossification 1.904E-8 4.393E-7 3.285E-6 1.889E-5 6 206
44 GO:0045778 positive regulation of ossification 2.255E-8 5.085E-7 3.802E-6 2.237E-5 5 99
45 GO:0090100 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 3.035E-8 6.690E-7 5.003E-6 3.011E-5 5 105
46 GO:0001701 in utero embryonic development 4.301E-8 9.275E-7 6.936E-6 4.267E-5 7 417
47 GO:0031053 primary miRNA processing 5.289E-8 1.116E-6 8.348E-6 5.247E-5 3 9
48 GO:0045667 regulation of osteoblast differentiation 6.726E-8 1.362E-6 1.018E-5 6.672E-5 5 123
49 GO:0001704 formation of primary germ layer 6.726E-8 1.362E-6 1.018E-5 6.672E-5 5 123
50 GO:0060485 mesenchyme development 8.325E-8 1.652E-6 1.235E-5 8.258E-5 6 264
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 17 input genes in category / 44 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071141 SMAD protein complex 5.201E-18 2.289E-16 1.001E-15 2.289E-16 6 8
2 GO:0005667 transcription factor complex 3.738E-10 8.223E-9 3.596E-8 1.645E-8 8 368
3 GO:0048179 activin receptor complex 5.892E-10 8.642E-9 3.779E-8 2.593E-8 3 3
4 GO:0071144 heteromeric SMAD protein complex 7.487E-7 8.236E-6 3.601E-5 3.294E-5 2 2
5 GO:0032444 activin responsive factor complex 2.245E-6 1.975E-5 8.638E-5 9.877E-5 2 3
6 GO:1902554 serine/threonine protein kinase complex 4.816E-5 3.532E-4 1.544E-3 2.119E-3 3 81
7 GO:1902911 protein kinase complex 7.045E-5 4.429E-4 1.936E-3 3.100E-3 3 92
8 GO:0043235 receptor complex 1.948E-4 1.071E-3 4.684E-3 8.570E-3 4 339
9 GO:0098802 plasma membrane receptor complex 5.109E-4 2.498E-3 1.092E-2 2.248E-2 3 180
10 GO:0005637 nuclear inner membrane 1.121E-3 4.931E-3 2.156E-2 4.931E-2 2 56
11 GO:0061695 transferase complex, transferring phosphorus-containing groups 1.234E-3 4.935E-3 2.158E-2
5.429E-2
 3 244
12 GO:0000790 nuclear chromatin 2.772E-3 1.017E-2 4.445E-2
1.220E-1
 3 324
13 GO:0090575 RNA polymerase II transcription factor complex 3.873E-3 1.306E-2
5.710E-2
1.704E-1
 2 105
14 GO:0044214 spanning component of plasma membrane 4.452E-3 1.306E-2
5.710E-2
1.959E-1
 1 5
15 GO:0089717 spanning component of membrane 4.452E-3 1.306E-2
5.710E-2
1.959E-1
 1 5
16 GO:0044798 nuclear transcription factor complex 6.226E-3 1.712E-2
7.486E-2
2.739E-1
 2 134
17 GO:0016342 catenin complex 8.000E-3 2.071E-2
9.054E-2
3.520E-1
 1 9
18 GO:0000785 chromatin 8.632E-3 2.110E-2
9.226E-2
3.798E-1
 3 487
Show 13 more annotations

4: Human Phenotype [Display Chart] 11 input genes in category / 869 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0003720 Generalized muscle hypertrophy 4.947E-5 4.299E-2
3.158E-1
 4.299E-2 2 5

5: Mouse Phenotype [Display Chart] 17 input genes in category / 1189 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0012157 rostral body truncation 6.001E-10 3.701E-7 2.835E-6 7.135E-7 5 28
2 MP:0002230 abnormal primitive streak formation 6.226E-10 3.701E-7 2.835E-6 7.403E-7 6 66
3 MP:0003886 abnormal embryonic epiblast morphology 1.368E-9 5.367E-7 4.111E-6 1.627E-6 6 75
4 MP:0012103 abnormal bilaminar embryonic disk morphology 2.194E-9 5.367E-7 4.111E-6 2.608E-6 6 81
5 MP:0005221 abnormal rostral-caudal axis patterning 2.302E-9 5.367E-7 4.111E-6 2.737E-6 7 153
6 MP:0001695 abnormal gastrulation 2.708E-9 5.367E-7 4.111E-6 3.220E-6 9 392
7 MP:0000267 abnormal heart development 3.308E-9 5.619E-7 4.303E-6 3.933E-6 9 401
8 MP:0003935 abnormal craniofacial development 6.495E-9 9.653E-7 7.393E-6 7.722E-6 9 433
9 MP:0003875 abnormal hair follicle regression 1.168E-8 1.543E-6 1.181E-5 1.388E-5 4 17
10 MP:0008000 increased ovary tumor incidence 2.486E-8 2.956E-6 2.263E-5 2.956E-5 5 57
11 MP:0011186 abnormal visceral endoderm morphology 3.518E-8 3.803E-6 2.912E-5 4.183E-5 5 61
12 MP:0001688 abnormal somite development 5.723E-8 4.723E-6 3.617E-5 6.805E-5 7 243
13 MP:0014141 abnormal mesoderm morphology 5.755E-8 4.723E-6 3.617E-5 6.842E-5 6 139
14 MP:0002231 abnormal primitive streak morphology 6.007E-8 4.723E-6 3.617E-5 7.142E-5 6 140
15 MP:0001674 abnormal germ layer development 6.539E-8 4.723E-6 3.617E-5 7.774E-5 6 142
16 MP:0001683 absent mesoderm 6.595E-8 4.723E-6 3.617E-5 7.841E-5 5 69
17 MP:0010426 abnormal heart and great artery attachment 6.768E-8 4.723E-6 3.617E-5 8.047E-5 7 249
18 MP:0010425 abnormal heart and great vessel attachment 7.150E-8 4.723E-6 3.617E-5 8.502E-5 7 251
19 MP:0009590 increased gonad tumor incidence 8.186E-8 5.123E-6 3.923E-5 9.734E-5 5 72
20 MP:0001680 abnormal mesoderm development 1.150E-7 6.839E-6 5.238E-5 1.368E-4 5 77
21 MP:0030574 increased hair follicle cell proliferation 2.048E-7 1.107E-5 8.477E-5 2.435E-4 3 8
22 MP:0012083 absent foregut 2.048E-7 1.107E-5 8.477E-5 2.435E-4 3 8
23 MP:0014138 abnormal germ layer morphology 2.680E-7 1.317E-5 1.009E-4 3.186E-4 6 180
24 MP:0001730 embryonic growth arrest 2.710E-7 1.317E-5 1.009E-4 3.223E-4 7 305
25 MP:0002884 abnormal pharyngeal arch morphology 2.769E-7 1.317E-5 1.009E-4 3.293E-4 6 181
26 MP:0001693 failure of primitive streak formation 3.176E-7 1.452E-5 1.112E-4 3.776E-4 4 37
27 MP:0000474 abnormal foregut morphology 3.546E-7 1.562E-5 1.196E-4 4.216E-4 4 38
28 MP:0003085 abnormal egg cylinder morphology 5.899E-7 2.466E-5 1.889E-4 7.013E-4 4 43
29 MP:0008393 absent primordial germ cells 6.016E-7 2.466E-5 1.889E-4 7.153E-4 3 11
30 MP:0010287 increased reproductive system tumor incidence 6.594E-7 2.529E-5 1.937E-4 7.841E-4 5 109
31 MP:0001726 abnormal allantois morphology 6.594E-7 2.529E-5 1.937E-4 7.841E-4 5 109
32 MP:0005029 abnormal amnion morphology 9.254E-7 3.438E-5 2.633E-4 1.100E-3 4 48
33 MP:0009373 abnormal cumulus expansion 1.041E-6 3.749E-5 2.871E-4 1.237E-3 3 13
34 MP:0030573 abnormal hair follicle cell proliferation 1.652E-6 5.613E-5 4.298E-4 1.964E-3 3 15
35 MP:0003579 increased ovarian carcinoma incidence 1.652E-6 5.613E-5 4.298E-4 1.964E-3 3 15
36 MP:0000269 abnormal heart looping 2.284E-6 7.542E-5 5.776E-4 2.715E-3 5 140
37 MP:0011733 fused somites 2.954E-6 9.493E-5 7.270E-4 3.512E-3 3 18
38 MP:0010402 ventricular septal defect 3.718E-6 1.163E-4 8.909E-4 4.421E-3 6 282
39 MP:0005435 hemoperitoneum 5.552E-6 1.693E-4 1.296E-3 6.602E-3 3 22
40 MP:0010736 abnormal extraembryonic ectoderm morphology 6.379E-6 1.896E-4 1.452E-3 7.584E-3 3 23
41 MP:0012245 abnormal hepatoblast migration 7.603E-6 2.205E-4 1.689E-3 9.041E-3 2 3
42 MP:0000427 abnormal hair cycle 9.277E-6 2.626E-4 2.011E-3 1.103E-2 4 85
43 MP:0011090 perinatal lethality, incomplete penetrance 9.527E-6 2.634E-4 2.018E-3 1.133E-2 6 332
44 MP:0002582 disorganized extraembryonic tissue 1.174E-5 3.172E-4 2.430E-3 1.396E-2 3 28
45 MP:0003920 abnormal heart right ventricle morphology 1.310E-5 3.461E-4 2.650E-3 1.557E-2 5 200
46 MP:0003967 abnormal follicle stimulating hormone level 1.385E-5 3.579E-4 2.741E-3 1.646E-2 4 94
47 MP:0006339 abnormal third pharyngeal arch morphology 1.452E-5 3.597E-4 2.755E-3 1.726E-2 3 30
48 MP:0011194 abnormal hair follicle physiology 1.452E-5 3.597E-4 2.755E-3 1.726E-2 3 30
49 MP:0012241 abnormal hepatoblast physiology 1.519E-5 3.686E-4 2.823E-3 1.806E-2 2 4
50 MP:0000270 abnormal heart tube morphology 1.568E-5 3.730E-4 2.856E-3 1.865E-2 4 97
Show 45 more annotations

6: Domain [Display Chart] 17 input genes in category / 64 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR001132 SMAD dom Dwarfin-type InterPro 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
2 3.90.520.10 - Gene3D 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
3 SM00524 DWB SMART 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
4 IPR013790 Dwarfin InterPro 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
5 PS51075 MH1 PROSITE 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
6 PF03166 MH2 Pfam 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
7 IPR013019 MAD homology MH1 InterPro 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
8 PS51076 MH2 PROSITE 6.467E-26 5.174E-25 2.454E-24 4.139E-24 8 8
9 SM00523 DWA SMART 3.196E-23 1.859E-22 8.821E-22 2.045E-21 8 12
10 IPR003619 MAD homology1 Dwarfin-type InterPro 3.196E-23 1.859E-22 8.821E-22 2.045E-21 8 12
11 PF03165 MH1 Pfam 3.196E-23 1.859E-22 8.821E-22 2.045E-21 8 12
12 IPR017855 SMAD dom-like InterPro 8.295E-22 4.084E-21 1.937E-20 5.309E-20 8 16
13 2.60.200.10 - Gene3D 8.295E-22 4.084E-21 1.937E-20 5.309E-20 8 16
14 IPR008984 SMAD FHA domain InterPro 4.776E-17 2.183E-16 1.036E-15 3.057E-15 8 52
15 IPR000472 Activin recp InterPro 9.707E-11 3.883E-10 1.842E-9 6.212E-9 4 10
16 PF01064 Activin recp Pfam 9.707E-11 3.883E-10 1.842E-9 6.212E-9 4 10
17 IPR000333 TGFB receptor InterPro 2.286E-10 8.604E-10 4.082E-9 1.463E-8 4 12
18 PS51256 GS PROSITE 2.167E-8 6.604E-8 3.133E-7 1.387E-6 3 7
19 IPR003605 GS dom InterPro 2.167E-8 6.604E-8 3.133E-7 1.387E-6 3 7
20 PF08515 TGF beta GS Pfam 2.167E-8 6.604E-8 3.133E-7 1.387E-6 3 7
21 SM00467 GS SMART 2.167E-8 6.604E-8 3.133E-7 1.387E-6 3 7
22 IPR008271 Ser/Thr kinase AS InterPro 2.535E-4 6.362E-4 3.018E-3 1.622E-2 4 357
23 PS00108 PROTEIN KINASE ST PROSITE 2.673E-4 6.362E-4 3.018E-3 1.711E-2 4 362
24 SM00119 HECTc SMART 2.684E-4 6.362E-4 3.018E-3 1.718E-2 2 27
25 PF00632 HECT Pfam 2.684E-4 6.362E-4 3.018E-3 1.718E-2 2 27
26 IPR000569 HECT dom InterPro 2.684E-4 6.362E-4 3.018E-3 1.718E-2 2 27
27 PS50237 HECT PROSITE 2.684E-4 6.362E-4 3.018E-3 1.718E-2 2 27
28 IPR017441 Protein kinase ATP BS InterPro 3.184E-4 7.169E-4 3.401E-3 2.038E-2 4 379
29 PF00069 Pkinase Pfam 3.248E-4 7.169E-4 3.401E-3 2.079E-2 4 381
30 PS00107 PROTEIN KINASE ATP PROSITE 6.567E-4 1.401E-3 6.646E-3 4.203E-2 4 459
31 PF00397 WW Pfam 8.179E-4 1.613E-3 7.653E-3
5.234E-2
 2 47
32 IPR000719 Prot kinase dom InterPro 8.326E-4 1.613E-3 7.653E-3
5.329E-2
 4 489
33 SM00456 WW SMART 8.530E-4 1.613E-3 7.653E-3
5.459E-2
 2 48
34 PS50011 PROTEIN KINASE DOM PROSITE 8.583E-4 1.613E-3 7.653E-3
5.493E-2
 4 493
35 IPR026710 MDS1 InterPro 9.074E-4 1.613E-3 7.653E-3
5.807E-2
 1 1
36 IPR015770 BMPR2 InterPro 9.074E-4 1.613E-3 7.653E-3
5.807E-2
 1 1
37 PS50020 WW DOMAIN 2 PROSITE 9.626E-4 1.621E-3 7.691E-3
6.161E-2
 2 51
38 PS01159 WW DOMAIN 1 PROSITE 9.626E-4 1.621E-3 7.691E-3
6.161E-2
 2 51
39 IPR001202 WW dom InterPro 1.001E-3 1.642E-3 7.789E-3
6.404E-2
 2 52
40 IPR024928 E3 ub ligase SMURF1 InterPro 1.814E-3 2.832E-3 1.343E-2
1.161E-1
 1 2
41 IPR030413 Evi1/Prdm16 InterPro 1.814E-3 2.832E-3 1.343E-2
1.161E-1
 1 2
42 PF12413 DLL N Pfam 2.720E-3 4.048E-3 1.920E-2
1.741E-1
 1 3
43 IPR022135 Distal-less N InterPro 2.720E-3 4.048E-3 1.920E-2
1.741E-1
 1 3
44 SM00220 S TKc SMART 3.886E-3 5.652E-3 2.681E-2
2.487E-1
 3 359
45 PF00168 C2 Pfam 6.160E-3 8.627E-3 4.093E-2
3.943E-1
 2 131
46 PF05605 zf-Di19 Pfam 6.335E-3 8.627E-3 4.093E-2
4.055E-1
 1 7
47 IPR008598 Di19 Zn binding dom InterPro 6.335E-3 8.627E-3 4.093E-2
4.055E-1
 1 7
48 SM00239 C2 SMART 6.718E-3 8.958E-3 4.250E-2
4.300E-1
 2 137
49 PS50004 C2 PROSITE 7.200E-3 9.405E-3 4.461E-2
4.608E-1
 2 142
50 2.60.40.150 - Gene3D 7.799E-3 9.983E-3 4.736E-2
4.991E-1
 2 148
Show 45 more annotations

7: Pathway [Display Chart] 16 input genes in category / 95 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83064 TGF-beta signaling pathway BioSystems: KEGG 1.252E-26 1.189E-24 6.108E-24 1.189E-24 13 84
2 P00052 TGF-beta signaling pathway PantherDB 3.829E-26 1.819E-24 9.341E-24 3.637E-24 13 91
3 1269522 Signaling by BMP BioSystems: REACTOME 6.566E-19 2.079E-17 1.068E-16 6.238E-17 8 24
4 137948 BMP receptor signaling BioSystems: Pathway Interaction Database 2.683E-17 6.372E-16 3.273E-15 2.549E-15 8 36
5 1026136 Signaling pathways regulating pluripotency of stem cells BioSystems: KEGG 1.640E-16 3.117E-15 1.601E-14 1.558E-14 10 139
6 137968 ALK1 signaling events BioSystems: Pathway Interaction Database 4.265E-16 6.753E-15 3.469E-14 4.052E-14 7 24
7 137983 ALK2 signaling events BioSystems: Pathway Interaction Database 7.137E-16 9.686E-15 4.975E-14 6.780E-14 6 11
8 1269621 Signaling by Activin BioSystems: REACTOME 2.244E-12 2.665E-11 1.369E-10 2.132E-10 5 13
9 M17400 ALK in cardiac myocytes MSigDB C2 BIOCARTA (v6.0) 3.527E-12 3.723E-11 1.912E-10 3.351E-10 6 37
10 PW:0000330 Bone morphogenetic proteins signaling Pathway Ontology 9.088E-12 8.633E-11 4.434E-10 8.633E-10 4 5
11 1270343 Signaling by NODAL BioSystems: REACTOME 3.527E-11 3.046E-10 1.564E-9 3.351E-9 5 21
12 PW:0000614 altered transforming growth factor-beta Smad dependent signaling Pathway Ontology 6.352E-11 4.641E-10 2.384E-9 6.034E-9 4 7
13 PW:0000331 activin signaling Pathway Ontology 6.352E-11 4.641E-10 2.384E-9 6.034E-9 4 7
14 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 1.136E-10 7.708E-10 3.959E-9 1.079E-8 5 26
15 1269524 TGF-beta receptor signaling activates SMADs BioSystems: REACTOME 4.777E-10 3.025E-9 1.554E-8 4.538E-8 5 34
16 1268895 Loss of Function of SMAD4 in Cancer BioSystems: REACTOME 1.742E-9 9.732E-9 4.999E-8 1.654E-7 3 3
17 1268896 SMAD4 MH2 Domain Mutants in Cancer BioSystems: REACTOME 1.742E-9 9.732E-9 4.999E-8 1.654E-7 3 3
18 138024 TGF-beta receptor signaling BioSystems: Pathway Interaction Database 3.982E-9 2.102E-8 1.080E-7 3.783E-7 5 51
19 PW:0000612 colorectal cancer Pathway Ontology 5.506E-9 2.753E-8 1.414E-7 5.231E-7 4 18
20 M18933 TGF beta signaling pathway MSigDB C2 BIOCARTA (v6.0) 6.969E-9 3.310E-8 1.700E-7 6.621E-7 4 19
21 749777 Hippo signaling pathway BioSystems: KEGG 2.349E-8 1.063E-7 5.458E-7 2.231E-6 6 154
22 1269525 Downregulation of TGF-beta receptor signaling BioSystems: REACTOME 3.136E-8 1.354E-7 6.956E-7 2.979E-6 4 27
23 1269523 Signaling by TGF-beta Receptor Complex BioSystems: REACTOME 3.286E-8 1.357E-7 6.971E-7 3.121E-6 5 77
24 1268899 SMAD2/3 MH2 Domain Mutants in Cancer BioSystems: REACTOME 6.076E-8 2.309E-7 1.186E-6 5.773E-6 3 7
25 1268897 Loss of Function of SMAD2/3 in Cancer BioSystems: REACTOME 6.076E-8 2.309E-7 1.186E-6 5.773E-6 3 7
26 1269528 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription BioSystems: REACTOME 8.242E-8 3.012E-7 1.547E-6 7.830E-6 4 34
27 1268894 Signaling by TGF-beta Receptor Complex in Cancer BioSystems: REACTOME 1.456E-7 5.123E-7 2.631E-6 1.383E-5 3 9
28 1269527 Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer BioSystems: REACTOME 2.873E-7 9.749E-7 5.008E-6 2.730E-5 4 46
29 138015 Regulation of cytoplasmic and nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 1.667E-6 5.459E-6 2.804E-5 1.583E-4 3 19
30 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 2.327E-6 7.367E-6 3.784E-5 2.210E-4 4 77
31 1269529 Downregulation of SMAD2/3:SMAD4 transcriptional activity BioSystems: REACTOME 3.036E-6 9.014E-6 4.630E-5 2.885E-4 3 23
32 M11420 CTCF: First Multivalent Nuclear Factor MSigDB C2 BIOCARTA (v6.0) 3.036E-6 9.014E-6 4.630E-5 2.885E-4 3 23
33 1427862 Ub-specific processing proteases BioSystems: REACTOME 6.847E-6 1.971E-5 1.012E-4 6.505E-4 5 225
34 1268898 SMAD2/3 Phosphorylation Motif Mutants in Cancer BioSystems: REACTOME 2.316E-5 6.471E-5 3.323E-4 2.200E-3 2 6
35 1427860 Deubiquitination BioSystems: REACTOME 2.894E-5 7.856E-5 4.035E-4 2.750E-3 5 303
36 P00057 Wnt signaling pathway PantherDB 2.987E-5 7.883E-5 4.049E-4 2.838E-3 5 305
37 1268905 TGFBR1 KD Mutants in Cancer BioSystems: REACTOME 4.316E-5 1.079E-4 5.542E-4 4.100E-3 2 8
38 1268903 Loss of Function of TGFBR1 in Cancer BioSystems: REACTOME 4.316E-5 1.079E-4 5.542E-4 4.100E-3 2 8
39 83106 Colorectal cancer BioSystems: KEGG 5.699E-5 1.388E-4 7.131E-4 5.414E-3 3 60
40 83108 Pancreatic cancer BioSystems: KEGG 6.917E-5 1.643E-4 8.438E-4 6.571E-3 3 64
41 83116 Chronic myeloid leukemia BioSystems: KEGG 9.437E-5 2.187E-4 1.123E-3 8.965E-3 3 71
42 83070 Adherens junction BioSystems: KEGG 9.840E-5 2.226E-4 1.143E-3 9.348E-3 3 72
43 1270344 Regulation of signaling by NODAL BioSystems: REACTOME 1.014E-4 2.241E-4 1.151E-3 9.636E-3 2 12
44 1319988 AGE-RAGE signaling pathway in diabetic complications BioSystems: KEGG 2.534E-4 5.470E-4 2.810E-3 2.407E-2 3 99
45 1469482 Th17 cell differentiation BioSystems: KEGG 3.186E-4 6.621E-4 3.401E-3 3.027E-2 3 107
46 M18215 Role of Tob in T-cell activation MSigDB C2 BIOCARTA (v6.0) 3.206E-4 6.621E-4 3.401E-3 3.046E-2 2 21
47 M2821 NFkB activation by Nontypeable Hemophilus influenzae MSigDB C2 BIOCARTA (v6.0) 4.204E-4 8.497E-4 4.364E-3 3.994E-2 2 24
48 83054 Cell cycle BioSystems: KEGG 4.912E-4 9.722E-4 4.993E-3 4.666E-2 3 124
49 M648 Cell Cycle: G1/S Check Point MSigDB C2 BIOCARTA (v6.0) 5.740E-4 1.113E-3 5.716E-3
5.453E-2
 2 28
50 921162 FoxO signaling pathway BioSystems: KEGG 5.897E-4 1.120E-3 5.755E-3
5.602E-2
 3 132
Show 45 more annotations

8: Pubmed [Display Chart] 17 input genes in category / 4891 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 10708948 The Smad pathway. Pubmed 5.106E-32 2.497E-28 2.266E-27 2.497E-28 9 9
2 10708949 TGF-beta signaling by Smad proteins. Pubmed 2.166E-28 3.532E-25 3.204E-24 1.060E-24 8 8
3 10647776 Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells. Pubmed 2.166E-28 3.532E-25 3.204E-24 1.060E-24 8 8
4 9759503 TGF-beta signal transduction. Pubmed 1.949E-27 2.384E-24 2.163E-23 9.535E-24 8 9
5 23620745 Spatio-temporal distribution of Smads and role of Smads/TGF-β/BMP-4 in the regulation of mouse bladder organogenesis. Pubmed 9.745E-27 9.533E-24 8.648E-23 4.766E-23 8 10
6 14656760 Smad expression during kidney development. Pubmed 1.072E-25 8.735E-23 7.924E-22 5.241E-22 8 12
7 10376010 Can't get no SMADisfaction: Smad proteins as positive and negative regulators of TGF-beta family signals. Pubmed 8.273E-25 5.780E-22 5.244E-21 4.046E-21 7 7
8 19211612 A new nonsense mutation of SMAD8 associated with pulmonary arterial hypertension. Pubmed 6.617E-24 4.045E-21 3.670E-20 3.236E-20 7 8
9 19018011 Holding their own: the noncanonical roles of Smad proteins. Pubmed 2.977E-23 1.456E-20 1.321E-19 1.456E-19 7 9
10 26555259 Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-β (TGF-β)/Smad Signaling. Pubmed 2.977E-23 1.456E-20 1.321E-19 1.456E-19 7 9
11 15221015 Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1). Pubmed 9.921E-23 3.984E-20 3.614E-19 4.852E-19 7 10
12 9436979 Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Pubmed 9.921E-23 3.984E-20 3.614E-19 4.852E-19 7 10
13 15621726 Bone morphogenetic proteins. Pubmed 1.059E-22 3.984E-20 3.614E-19 5.179E-19 8 23
14 24008158 Downregulation of bone morphogenetic protein receptor axis during HIV-1 and cocaine-mediated pulmonary smooth muscle hyperplasia: implications for HIV-related pulmonary arterial hypertension. Pubmed 2.728E-22 9.529E-20 8.645E-19 1.334E-18 7 11
15 11169847 Immunohistochemical expression of Smads 1-6 in the 15-day gestation mouse embryo: signaling by BMPs and TGF-betas. Pubmed 2.872E-21 7.023E-19 6.372E-18 1.405E-17 6 6
16 9256479 Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Pubmed 2.872E-21 7.023E-19 6.372E-18 1.405E-17 6 6
17 10400677 SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. Pubmed 2.872E-21 7.023E-19 6.372E-18 1.405E-17 6 6
18 18069690 SMAD expression in the testis: an insight into BMP regulation of spermatogenesis. Pubmed 2.872E-21 7.023E-19 6.372E-18 1.405E-17 6 6
19 18952608 Smad7 is required for the development and function of the heart. Pubmed 2.872E-21 7.023E-19 6.372E-18 1.405E-17 6 6
20 11850197 Dynamic regulation of Smad expression during mesenchyme to epithelium transition in the metanephric kidney. Pubmed 2.872E-21 7.023E-19 6.372E-18 1.405E-17 6 6
21 12370310 Identification of mZnf8, a mouse Krüppel-like transcriptional repressor, as a novel nuclear interaction partner of Smad1. Pubmed 2.010E-20 4.468E-18 4.054E-17 9.830E-17 6 7
22 11163184 Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Pubmed 2.010E-20 4.468E-18 4.054E-17 9.830E-17 6 7
23 20734064 A large-scale candidate gene association study of age at menarche and age at natural menopause. Pubmed 2.627E-20 5.587E-18 5.069E-17 1.285E-16 11 275
24 23610558 Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension. Pubmed 4.157E-20 8.472E-18 7.686E-17 2.033E-16 7 19
25 15359284 The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. Pubmed 8.038E-20 1.456E-17 1.321E-16 3.931E-16 6 8
26 23804438 Computational modelling of Smad-mediated negative feedback and crosstalk in the TGF-β superfamily network. Pubmed 8.038E-20 1.456E-17 1.321E-16 3.931E-16 6 8
27 11278251 Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation. Pubmed 8.038E-20 1.456E-17 1.321E-16 3.931E-16 6 8
28 14729481 Tgf-beta3-induced palatal fusion is mediated by Alk-5/Smad pathway. Pubmed 2.411E-19 3.930E-17 3.566E-16 1.179E-15 6 9
29 29247325 TGF-β signaling inhibits canonical BMP signaling pathway during palate development. Pubmed 2.411E-19 3.930E-17 3.566E-16 1.179E-15 6 9
30 12857866 Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Pubmed 2.411E-19 3.930E-17 3.566E-16 1.179E-15 6 9
31 16890162 Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Pubmed 6.025E-19 9.506E-17 8.624E-16 2.947E-15 6 10
32 21538804 BMPR-II is dispensable for formation of the limb skeleton. Pubmed 2.650E-18 3.927E-16 3.563E-15 1.296E-14 6 12
33 16435884 Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. Pubmed 2.650E-18 3.927E-16 3.563E-15 1.296E-14 6 12
34 15761153 High-throughput mapping of a dynamic signaling network in mammalian cells. Pubmed 2.863E-18 4.118E-16 3.736E-15 1.400E-14 10 256
35 17628518 Endoglin is required for myogenic differentiation potential of neural crest stem cells. Pubmed 4.920E-18 6.684E-16 6.064E-15 2.406E-14 6 13
36 23011393 Tbx1 genetically interacts with the transforming growth factor-β/bone morphogenetic protein inhibitor Smad7 during great vessel remodeling. Pubmed 4.920E-18 6.684E-16 6.064E-15 2.406E-14 6 13
37 25274628 An atypical canonical bone morphogenetic protein (BMP) signaling pathway regulates Msh homeobox 1 (Msx1) expression during odontogenesis. Pubmed 8.608E-18 1.040E-15 9.432E-15 4.210E-14 6 14
38 18566469 Functions of the type 1 BMP receptor Acvr1 (Alk2) in lens development: cell proliferation, terminal differentiation, and survival. Pubmed 9.140E-18 1.040E-15 9.432E-15 4.470E-14 5 5
39 8673135 Mad-related genes in the human. Pubmed 9.140E-18 1.040E-15 9.432E-15 4.470E-14 5 5
40 25141865 Brightfield proximity ligation assay reveals both canonical and mixed transforming growth factor-β/bone morphogenetic protein Smad signaling complexes in tissue sections. Pubmed 9.140E-18 1.040E-15 9.432E-15 4.470E-14 5 5
41 15817471 Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. Pubmed 9.140E-18 1.040E-15 9.432E-15 4.470E-14 5 5
42 10583507 Smad8B, a Smad8 splice variant lacking the SSXS site that inhibits Smad8-mediated signalling. Pubmed 9.140E-18 1.040E-15 9.432E-15 4.470E-14 5 5
43 11231077 Developmentally regulated expression of Smad3, Smad4, Smad6, and Smad7 involved in TGF-beta signaling. Pubmed 9.140E-18 1.040E-15 9.432E-15 4.470E-14 5 5
44 22560297 Congenital asplenia in mice and humans with mutations in a Pbx/Nkx2-5/p15 module. Pubmed 1.108E-17 1.232E-15 1.117E-14 5.420E-14 9 167
45 19717565 p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. Pubmed 3.545E-17 3.853E-15 3.495E-14 1.734E-13 6 17
46 15849193 Repression of bone morphogenetic protein and activin-inducible transcription by Evi-1. Pubmed 5.482E-17 5.705E-15 5.176E-14 2.681E-13 5 6
47 17467076 PRDM16/MEL1: a novel Smad binding protein expressed in murine embryonic orofacial tissue. Pubmed 5.482E-17 5.705E-15 5.176E-14 2.681E-13 5 6
48 17585069 Myocardial smad4 is essential for cardiogenesis in mouse embryos. Pubmed 1.553E-16 1.582E-14 1.435E-13 7.594E-13 6 21
49 14701756 CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription. Pubmed 1.918E-16 1.737E-14 1.576E-13 9.382E-13 5 7
50 12815042 Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3. Pubmed 1.918E-16 1.737E-14 1.576E-13 9.382E-13 5 7
Show 45 more annotations

9: Interaction [Display Chart] 17 input genes in category / 1359 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SMAD6 SMAD6 interactions 6.966E-25 9.467E-22 7.377E-21 9.467E-22 11 53
2 int:SMAD7 SMAD7 interactions 8.539E-24 5.803E-21 4.521E-20 1.161E-20 12 108
3 int:SMAD1 SMAD1 interactions 1.036E-20 4.694E-18 3.658E-17 1.408E-17 12 191
4 int:SMAD5 SMAD5 interactions 1.895E-20 5.799E-18 4.519E-17 2.575E-17 10 75
5 int:SMAD2 SMAD2 interactions 2.134E-20 5.799E-18 4.519E-17 2.899E-17 13 306
6 int:ACVR1B ACVR1B interactions 8.544E-20 1.935E-17 1.508E-16 1.161E-16 9 48
7 int:ACVR1 ACVR1 interactions 4.347E-17 8.440E-15 6.576E-14 5.908E-14 9 92
8 int:SMAD3 SMAD3 interactions 4.977E-17 8.454E-15 6.588E-14 6.763E-14 12 383
9 int:SMAD4 SMAD4 interactions 6.922E-17 1.045E-14 8.144E-14 9.407E-14 11 262
10 int:SMAD9 SMAD9 interactions 1.760E-15 2.392E-13 1.864E-12 2.392E-12 9 137
11 int:TOB1 TOB1 interactions 5.701E-15 7.043E-13 5.488E-12 7.747E-12 7 43
12 int:WWP1 WWP1 interactions 9.973E-15 1.129E-12 8.801E-12 1.355E-11 8 93
13 int:RASD2 RASD2 interactions 2.143E-14 2.241E-12 1.746E-11 2.913E-11 6 22
14 int:TGFBR1 TGFBR1 interactions 5.376E-14 5.219E-12 4.067E-11 7.306E-11 9 199
15 int:ZEB2 ZEB2 interactions 6.600E-14 5.979E-12 4.659E-11 8.969E-11 6 26
16 int:RUNX2 RUNX2 interactions 1.218E-13 1.035E-11 8.063E-11 1.656E-10 7 65
17 int:PRDM16 PRDM16 interactions 1.967E-13 1.573E-11 1.226E-10 2.674E-10 5 11
18 int:USP15 USP15 interactions 2.836E-13 2.141E-11 1.669E-10 3.854E-10 9 239
19 int:SMURF2 SMURF2 interactions 3.033E-13 2.169E-11 1.690E-10 4.122E-10 8 141
20 int:ZNF8 ZNF8 interactions 5.475E-13 3.543E-11 2.761E-10 7.440E-10 5 13
21 int:RASL12 RASL12 interactions 5.475E-13 3.543E-11 2.761E-10 7.440E-10 5 13
22 int:SMURF1 SMURF1 interactions 6.078E-13 3.755E-11 2.926E-10 8.260E-10 10 406
23 int:PIAS4 PIAS4 interactions 4.179E-12 2.469E-10 1.924E-9 5.679E-9 7 106
24 int:PEX6 PEX6 interactions 1.423E-11 7.737E-10 6.029E-9 1.934E-8 5 23
25 int:COL3A1 COL3A1 interactions 1.423E-11 7.737E-10 6.029E-9 1.934E-8 5 23
26 int:COL5A1 COL5A1 interactions 5.006E-11 2.605E-9 2.030E-8 6.803E-8 5 29
27 int:DVL1 DVL1 interactions 5.176E-11 2.605E-9 2.030E-8 7.034E-8 6 74
28 int:MECOM MECOM interactions 7.155E-11 3.472E-9 2.706E-8 9.723E-8 5 31
29 int:CSH2 CSH2 interactions 1.217E-10 5.705E-9 4.445E-8 1.654E-7 4 10
30 int:BAMBI BAMBI interactions 1.912E-10 8.120E-9 6.327E-8 2.598E-7 4 11
31 int:RAB38 RAB38 interactions 1.912E-10 8.120E-9 6.327E-8 2.598E-7 4 11
32 int:GSC GSC interactions 1.912E-10 8.120E-9 6.327E-8 2.598E-7 4 11
33 int:CXXC5 CXXC5 interactions 2.866E-10 1.146E-8 8.927E-8 3.895E-7 4 12
34 int:CSH1 CSH1 interactions 2.866E-10 1.146E-8 8.927E-8 3.895E-7 4 12
35 int:MBD1 MBD1 interactions 3.138E-10 1.218E-8 9.493E-8 4.264E-7 5 41
36 int:ZEB1 ZEB1 interactions 3.560E-10 1.344E-8 1.047E-7 4.838E-7 5 42
37 int:RUNX3 RUNX3 interactions 4.026E-10 1.479E-8 1.152E-7 5.471E-7 5 43
38 int:TGFBR2 TGFBR2 interactions 4.172E-10 1.492E-8 1.163E-7 5.670E-7 6 104
39 int:STRAP STRAP interactions 5.250E-10 1.830E-8 1.426E-7 7.135E-7 6 108
40 int:INHBB INHBB interactions 7.890E-10 2.681E-8 2.089E-7 1.072E-6 4 15
41 int:BMPR1A BMPR1A interactions 8.540E-10 2.831E-8 2.206E-7 1.161E-6 6 117
42 int:RHEBL1 RHEBL1 interactions 1.051E-9 3.402E-8 2.651E-7 1.429E-6 4 16
43 int:LEF1 LEF1 interactions 1.193E-9 3.772E-8 2.939E-7 1.622E-6 5 53
44 int:DDX5 DDX5 interactions 2.663E-9 8.225E-8 6.409E-7 3.619E-6 7 265
45 int:EIF4ENIF1 EIF4ENIF1 interactions 3.689E-9 1.114E-7 8.682E-7 5.014E-6 5 66
46 int:BMPR2 BMPR2 interactions 5.756E-9 1.701E-7 1.325E-6 7.823E-6 5 72
47 int:KDM6B KDM6B interactions 6.110E-9 1.767E-7 1.377E-6 8.303E-6 4 24
48 int:ZMYM2 ZMYM2 interactions 7.584E-9 2.147E-7 1.673E-6 1.031E-5 5 76
49 int:USP9X USP9X interactions 9.357E-9 2.595E-7 2.022E-6 1.272E-5 6 174
50 int:TGFBRAP1 TGFBRAP1 interactions 1.007E-8 2.738E-7 2.133E-6 1.369E-5 4 27
Show 45 more annotations

10: Cytoband [Display Chart] 17 input genes in category / 15 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18q21.1 18q21.1 9.573E-7 1.436E-5 4.765E-5 1.436E-5 3 40
2 15q22.33 15q22.33 9.807E-4 4.904E-3 1.627E-2 1.471E-2 1 2
3 2q23-q24 2q23-q24 9.807E-4 4.904E-3 1.627E-2 1.471E-2 1 2
4 13q12-q14 13q12-q14 1.471E-3 5.515E-3 1.830E-2 2.206E-2 1 3
5 15q21-q22 15q21-q22 2.939E-3 8.818E-3 2.926E-2 4.409E-2 1 6
6 2q33-q34 2q33-q34 4.406E-3 1.102E-2 3.655E-2
6.609E-2
 1 9
7 4q31 4q31 5.383E-3 1.153E-2 3.827E-2
8.074E-2
 1 11
8 2q22.3 2q22.3 7.333E-3 1.375E-2 4.563E-2
1.100E-1
 1 15
9 3q26.2 3q26.2 1.316E-2 2.047E-2
6.793E-2
1.975E-1
 1 27
10 2q24.1 2q24.1 1.365E-2 2.047E-2
6.793E-2
2.047E-1
 1 28
11 17q21 17q21 3.046E-2 4.154E-2
1.378E-1
4.569E-1
 1 63
12 12q13 12q13 3.427E-2 4.283E-2
1.421E-1
5.140E-1
 1 71
Show 7 more annotations

11: Transcription Factor Binding Site [Display Chart] 16 input genes in category / 206 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$SMAD3 Q6 V$SMAD3 Q6 2.230E-4 4.594E-2
2.714E-1
 4.594E-2 4 193

12: Gene Family [Display Chart] 16 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 750 SMAD family genenames.org 4.329E-26 3.463E-25 9.411E-25 3.463E-25 8 8
2 345 Type 1 receptor serine/threonine kinases|CD molecules genenames.org 1.949E-8 7.795E-8 2.119E-7 1.559E-7 3 7
3 838 C2 and WW domain containing genenames.org 3.513E-3 8.780E-3 2.386E-2 2.811E-2 1 4
4 346 Type 2 receptor serine/threonine kinases genenames.org 4.390E-3 8.780E-3 2.386E-2 3.512E-2 1 5
5 529 Zinc fingers C2H2-type|ZF class homeoboxes and pseudogenes genenames.org 1.312E-2 1.980E-2
5.382E-2
1.049E-1
 1 15
6 1197 Zinc fingers C2H2-type|PR/SET domain family genenames.org 1.485E-2 1.980E-2
5.382E-2
1.188E-1
 1 17
7 487 Lysine methyltransferases|RNA binding motif containing genenames.org 2.950E-2 3.371E-2
9.162E-2
2.360E-1
 1 34
Show 2 more annotations

13: Coexpression [Display Chart] 17 input genes in category / 1816 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5896 Genes up-regulated in response to TGFB1 [GeneID=7040]. MSigDB H: Hallmark Gene Sets (v6.0) 4.809E-15 8.733E-12 7.058E-11 8.733E-12 7 54
2 M15804 Examples of transcription factors whose activities are regulated by MAPK1 and MAPK3 [GeneID=5594;5595] phosphorylation. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.834E-11 8.929E-8 7.216E-7 1.786E-7 4 12
3 14977634-Figure8b Rat Viral Sparmann04 52genes GeneSigDB 6.198E-9 3.752E-6 3.032E-5 1.125E-5 4 31
4 15834136-Table8 Mouse Bone Kalajzic05 8genes BMP pathway GeneSigDB 1.841E-8 8.357E-6 6.754E-5 3.343E-5 3 8
5 15834136-Table9 Mouse Bone Kalajzic05 11genes GeneSigDB 2.760E-8 1.002E-5 8.101E-5 5.012E-5 3 9
6 20460173-ImmPortTGF-betaFamilyMemberReceptors Human Immune Kong10 12genes ImmPort TGF-betaFamilyMemberReceptors GeneSigDB 7.218E-8 2.185E-5 1.766E-4 1.311E-4 3 12
7 20521089-SuppTable1a Human Breast Blick10 69genes EMT up GeneSigDB 1.485E-7 3.384E-5 2.735E-4 2.698E-4 4 67
8 15548695-Table2 Human Prostate Haudenschild04 18genes GeneSigDB 1.491E-7 3.384E-5 2.735E-4 2.707E-4 3 15
9 M3955 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes up-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.880E-7 3.793E-5 3.065E-4 3.413E-4 4 71
10 18787207-Table1 Mouse Viral Craft08 83genes GeneSigDB 2.223E-7 4.037E-5 3.263E-4 4.037E-4 4 74
11 M18219 Growth factor signaling components up-regulated in hepatocellular carcinoma (HCC). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.030E-7 8.304E-5 6.711E-4 9.135E-4 3 22
12 18689800-TableS6 Human EmbryonicStemCell Thomas08 113genes GeneSigDB 1.138E-6 1.722E-4 1.392E-3 2.066E-3 4 111
13 M12313 Genes up-regulated in MEWO cells (melanoma) after 96 h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.405E-6 1.962E-4 1.586E-3 2.551E-3 4 117
14 19286929-SuppTable2f Mouse Lung Rangasamy09 39genes GeneSigDB 2.521E-6 3.270E-4 2.642E-3 4.577E-3 3 37
15 18519693-Table1 Human StemCell Mishra08 289genes GeneSigDB 8.138E-6 9.853E-4 7.963E-3 1.478E-2 4 182
16 M9031 Genes down-regulated in macrophages with heterozygous knockout of HDAC3 [GeneID=8841]: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 1.072E-3 8.664E-3 2.144E-2 4 200
17 M5705 Genes down-regulated in comparsion of sfActCD4TGF versus ActCD4TGF (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 1.072E-3 8.664E-3 2.144E-2 4 200
18 M4656 Genes down-regulated in comparison of naive CD8 T cells versus PD-1 high CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 1.072E-3 8.664E-3 2.144E-2 4 200
19 M4659 Genes down-regulated in comparison of naive CD8 T cells versus PD-1 low CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 1.072E-3 8.664E-3 2.144E-2 4 200
20 M6044 Genes up-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by IL-12 (48h). MSigDB C7: Immunologic Signatures (v6.0) 1.181E-5 1.072E-3 8.664E-3 2.144E-2 4 200
21 M14722 Genes down-regulated in A549 cells (lung cancer) after treatment with AZD0530 [PubChem=10302451], a SRC [GeneID=6714] kinase inhibitor. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.419E-5 1.227E-3 9.918E-3 2.577E-2 2 8
22 M4397 Genes from the black module which are down-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.784E-5 2.298E-3 1.857E-2
5.055E-2
 2 11
23 12086872-Table12d Human Leukemia Yeoh02 93genes GeneSigDB 3.247E-5 2.564E-3 2.072E-2
5.896E-2
 3 86
24 M13251 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 14 h time point that were not down-regulated at the previous time point, 12 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.550E-5 4.200E-3 3.394E-2
1.008E-1
 4 297
25 15170602-Table3 Human Lymphoma Valet04 24genes GeneSigDB 6.061E-5 4.403E-3 3.558E-2
1.101E-1
 2 16
26 15950496-Table3a Human Leukemia Gebauer05 19genes GeneSigDB 8.625E-5 5.801E-3 4.689E-2
1.566E-1
 2 19
27 M1821 Genes important for embryonic germ cell, based on mouse models with female fertility defects. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.625E-5 5.801E-3 4.689E-2
1.566E-1
 2 19
28 M13537 Genes up-regulated in MEWO cells (melanoma) after 48h of methionine [PubChem=876] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.063E-4 6.784E-3
5.483E-2
1.930E-1
 3 128
29 M10761 Genes up-regulated in the HMEC cells (primary mammary epithelium) upon expression of the transcriptionally active isoform of TP63 [GeneID=8626] off adenoviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.083E-4 6.784E-3
5.483E-2
1.967E-1
 4 353
30 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 1.272E-4 7.536E-3
6.090E-2
2.310E-1
 4 368
31 M449 Genes up-regulated in control CD4 [GeneID=920] T cells versus those infected with HIV-1 viruses lacking Env and Nef. MSigDB C7: Immunologic Signatures (v6.0) 1.300E-4 7.536E-3
6.090E-2
2.360E-1
 3 137
32 M19245 'Early-TGFB1 signature': genes overexpressed in primary hepatocytes at an early phase of TGFB1 [GeneID=7040] treatment; is associated with a less invasive phenotype. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.328E-4 7.536E-3
6.090E-2
2.411E-1
 3 138
33 20081105-Table4 Human Breast Nagaraja10 25genes mir-182Knockdown GeneSigDB 1.389E-4 7.645E-3
6.178E-2
2.523E-1
 2 24
34 12917485-Table9 Human Breast Sotiriou03 485genes Survival GeneSigDB 1.574E-4 8.409E-3
6.796E-2
2.859E-1
 4 389
35 20145155-Table1 Human StemCell Lottaz10 30genes GeneSigDB 1.899E-4 9.622E-3
7.776E-2
3.449E-1
 2 28
36 M12595 Class T (tolerizeable) genes: induced during the first LPS stimulation and either not re-induced or induced to a much lesser degree in tolerant macrophages. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.907E-4 9.622E-3
7.776E-2
3.464E-1
 3 156
37 M10311 Genes down-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 6 h time point that were not down-regulated at the previous time point, 4 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.055E-4 1.009E-2
8.152E-2
3.732E-1
 3 160
38 M14557 Genes up-regulated by expression of GAB2 [GeneID=9846] in K562 cells (chronic myeloid leukemia (CML) cell line with p210 BCR-ABL [GeneID=613;25]). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.333E-4 1.115E-2
9.012E-2
4.237E-1
 2 31
39 M2839 Genes up-regulated in a panel of epithelial cell lines by TGFB1 [Gene ID=7040]. MSigDB C6: Oncogenic Signatures (v6.0) 3.511E-4 1.261E-2
1.019E-1
6.376E-1
 3 192
40 17909013-table2 Mouse Prostate Banach-Petrosky07 55genes GeneSigDB 3.517E-4 1.261E-2
1.019E-1
6.387E-1
 2 38
41 M8119 Genes up-regulated in NFKB1 and IL10 [GeneID=4790;3586] knockout macrophages stimulated by LPS versus those also stimulated by IL10 [GeneID=3586]. MSigDB C7: Immunologic Signatures (v6.0) 3.899E-4 1.261E-2
1.019E-1
7.081E-1
 3 199
42 M6388 Genes up-regulated in B lymphocytes: naïve versus memory. MSigDB C7: Immunologic Signatures (v6.0) 3.899E-4 1.261E-2
1.019E-1
7.081E-1
 3 199
43 M8381 Genes up-regulated in CD4 [GeneID=920] T cells: progesterone [PubChem=5994] versus TGFB1 [GeneID=7040] and progesterone [PubChem=5994]. MSigDB C7: Immunologic Signatures (v6.0) 3.899E-4 1.261E-2
1.019E-1
7.081E-1
 3 199
44 M7219 Genes up-regulated in mouse embryonic fibroblasts (MEF): control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.899E-4 1.261E-2
1.019E-1
7.081E-1
 3 199
45 M3454 Genes down-regulated in comparison of CD4 [GeneID=920] CD8 thymocytes versus T cells from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.261E-2
1.019E-1
7.185E-1
 3 200
46 M5623 Genes up-regulated in comparison of CD4 [GeneID=920] T cells treated with TGFB1 [GeneID=7040] versus those treated with TGFB3 [GeneID=7043] and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.261E-2
1.019E-1
7.185E-1
 3 200
47 M5720 Genes up-regulated in comparison of NK cells versus total splenocytes. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.261E-2
1.019E-1
7.185E-1
 3 200
48 M9035 Genes up-regulated in macrophages with heterozygous knockout of HDAC3 [GeneID=8841]: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.261E-2
1.019E-1
7.185E-1
 3 200
49 M6965 Genes up-regulated in monocyte-derived dendritic cells: control versus TNF [GeneID=7124] inhibitor etanercept. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.261E-2
1.019E-1
7.185E-1
 3 200
50 M9278 Genes up-regulated in CD8 T cells 3 days after immunization: control versus IL2 [GeneID=3558] treatment. MSigDB C7: Immunologic Signatures (v6.0) 3.957E-4 1.261E-2
1.019E-1
7.185E-1
 3 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 17 input genes in category / 1256 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Facebase RNAseq e9.5 Mandibular Arch 500 K4 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 500 k-means-cluster#4 FaceBase_RNAseq 3.468E-5 4.356E-2
3.360E-1
 4.356E-2 3 83
2 gudmap dev gonad e11.5 M GonMes Sma k3 1000 dev gonad e11.5 M GonMes Sma k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 8.411E-5 4.738E-2
3.654E-1
1.056E-1
 4 312
3 gudmap dev gonad e11.5 M GonadVasMes Flk k1 1000 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse ST 1.0 1.146E-4 4.738E-2
3.654E-1
1.439E-1
 4 338
4 Facebase RNAseq e9.5 Mandibular Arch 1000 K1 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 1000 k-means-cluster#1 FaceBase_RNAseq 1.509E-4 4.738E-2
3.654E-1
1.895E-1
 3 136

15: Computational [Display Chart] 12 input genes in category / 59 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 17 input genes in category / 952 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-942:PITA hsa-miR-942:PITA TOP PITA 1.026E-8 8.643E-6 6.427E-5 9.765E-6 5 323
2 hsa-miR-323-3p:PITA hsa-miR-323-3p:PITA TOP PITA 2.428E-8 8.643E-6 6.427E-5 2.311E-5 5 384
3 hsa-miR-1322:PITA hsa-miR-1322:PITA TOP PITA 2.724E-8 8.643E-6 6.427E-5 2.593E-5 4 135
4 hsa-miR-205-5p:Functional MTI Functional MTI miRTarbase 9.041E-8 2.152E-5 1.600E-4 8.607E-5 4 182
5 hsa-miR-145-5p:Functional MTI Functional MTI miRTarbase 2.643E-7 5.033E-5 3.743E-4 2.516E-4 4 238
6 GTGCAAT,MIR-25:MSigDB GTGCAAT,MIR-25:MSigDB MSigDB 5.730E-7 5.455E-5 4.057E-4 5.455E-4 4 289
7 GTGCAAT,MIR-32:MSigDB GTGCAAT,MIR-32:MSigDB MSigDB 5.730E-7 5.455E-5 4.057E-4 5.455E-4 4 289
8 GTGCAAT,MIR-92:MSigDB GTGCAAT,MIR-92:MSigDB MSigDB 5.730E-7 5.455E-5 4.057E-4 5.455E-4 4 289
9 GTGCAAT,MIR-363:MSigDB GTGCAAT,MIR-363:MSigDB MSigDB 5.730E-7 5.455E-5 4.057E-4 5.455E-4 4 289
10 GTGCAAT,MIR-367:MSigDB GTGCAAT,MIR-367:MSigDB MSigDB 5.730E-7 5.455E-5 4.057E-4 5.455E-4 4 289
11 hsa-miR-323a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.232E-7 5.856E-5 4.355E-4 6.885E-4 3 75
12 hsa-miR-203a-3p:Functional MTI Functional MTI miRTarbase 7.382E-7 5.856E-5 4.355E-4 7.027E-4 4 308
13 hsa-miR-135b-5p:Functional MTI Functional MTI miRTarbase 9.829E-7 7.183E-5 5.341E-4 9.357E-4 3 83
14 hsa-miR-153-3p:Functional MTI Functional MTI miRTarbase 1.056E-6 7.183E-5 5.341E-4 1.006E-3 3 85
15 hsa-miR-1252:PITA hsa-miR-1252:PITA TOP PITA 1.545E-6 9.806E-5 7.292E-4 1.471E-3 4 371
16 hsa-miR-130a-3p:Functional MTI Functional MTI miRTarbase 2.041E-6 1.166E-4 8.672E-4 1.943E-3 4 398
17 hsa-miR-145:PITA hsa-miR-145:PITA TOP PITA 2.102E-6 1.166E-4 8.672E-4 2.001E-3 4 401
18 TGCACTT,MIR-519A:MSigDB TGCACTT,MIR-519A:MSigDB MSigDB 2.549E-6 1.166E-4 8.672E-4 2.426E-3 4 421
19 TGCACTT,MIR-519B:MSigDB TGCACTT,MIR-519B:MSigDB MSigDB 2.549E-6 1.166E-4 8.672E-4 2.426E-3 4 421
20 TGCACTT,MIR-519C:MSigDB TGCACTT,MIR-519C:MSigDB MSigDB 2.549E-6 1.166E-4 8.672E-4 2.426E-3 4 421
21 hsa-miR-485-3p:PITA hsa-miR-485-3p:PITA TOP PITA 2.573E-6 1.166E-4 8.672E-4 2.449E-3 4 422
22 hsa-miR-27a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.745E-6 1.188E-4 8.834E-4 2.614E-3 4 429
23 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 3.089E-6 1.252E-4 9.308E-4 2.941E-3 4 442
24 hsa-miR-135a:PITA hsa-miR-135a:PITA TOP PITA 3.287E-6 1.252E-4 9.308E-4 3.129E-3 4 449
25 hsa-miR-135b:PITA hsa-miR-135b:PITA TOP PITA 3.287E-6 1.252E-4 9.308E-4 3.129E-3 4 449
26 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 3.524E-6 1.253E-4 9.321E-4 3.355E-3 4 457
27 hsa-miR-1277:mirSVR lowEffct hsa-miR-1277:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.555E-6 1.253E-4 9.321E-4 3.384E-3 4 458
28 hsa-miR-182:PITA hsa-miR-182:PITA TOP PITA 4.243E-6 1.268E-4 9.430E-4 4.039E-3 4 479
29 hsa-miR-32:PITA hsa-miR-32:PITA TOP PITA 4.278E-6 1.268E-4 9.430E-4 4.072E-3 4 480
30 hsa-miR-363:PITA hsa-miR-363:PITA TOP PITA 4.492E-6 1.268E-4 9.430E-4 4.277E-3 4 486
31 hsa-miR-25:PITA hsa-miR-25:PITA TOP PITA 4.529E-6 1.268E-4 9.430E-4 4.311E-3 4 487
32 hsa-miR-367:PITA hsa-miR-367:PITA TOP PITA 4.529E-6 1.268E-4 9.430E-4 4.311E-3 4 487
33 hsa-miR-92b:PITA hsa-miR-92b:PITA TOP PITA 4.529E-6 1.268E-4 9.430E-4 4.311E-3 4 487
34 hsa-miR-92a:PITA hsa-miR-92a:PITA TOP PITA 4.529E-6 1.268E-4 9.430E-4 4.311E-3 4 487
35 hsa-miR-200a-3p:Functional MTI Functional MTI miRTarbase 5.840E-6 1.589E-4 1.181E-3 5.560E-3 3 150
36 hsa-miR-1243:PITA hsa-miR-1243:PITA TOP PITA 6.444E-6 1.704E-4 1.267E-3 6.134E-3 3 155
37 hsa-miR-199a-5p:Non-Functional MTI Non-Functional MTI miRTarbase 7.913E-6 2.018E-4 1.501E-3 7.533E-3 3 166
38 hsa-miR-642:PITA hsa-miR-642:PITA TOP PITA 8.056E-6 2.018E-4 1.501E-3 7.669E-3 3 167
39 hsa-miR-125a-3p:PITA hsa-miR-125a-3p:PITA TOP PITA 9.110E-6 2.224E-4 1.654E-3 8.672E-3 3 174
40 hsa-miR-552:PITA hsa-miR-552:PITA TOP PITA 1.185E-5 2.820E-4 2.097E-3 1.128E-2 3 190
41 hsa-miR-876-5p:PITA hsa-miR-876-5p:PITA TOP PITA 1.340E-5 3.112E-4 2.315E-3 1.276E-2 3 198
42 hsa-miR-593:PITA hsa-miR-593:PITA TOP PITA 1.553E-5 3.520E-4 2.617E-3 1.478E-2 3 208
43 hsa-miR-612:PITA hsa-miR-612:PITA TOP PITA 1.690E-5 3.657E-4 2.720E-3 1.609E-2 3 214
44 hsa-miR-1285:PITA hsa-miR-1285:PITA TOP PITA 1.690E-5 3.657E-4 2.720E-3 1.609E-2 3 214
45 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 3.054E-5 6.195E-4 4.607E-3 2.907E-2 3 261
46 hsa-miR-18a-5p:Functional MTI Functional MTI miRTarbase 3.088E-5 6.195E-4 4.607E-3 2.940E-2 3 262
47 hsa-miR-138:PITA hsa-miR-138:PITA TOP PITA 3.124E-5 6.195E-4 4.607E-3 2.974E-2 3 263
48 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 3.124E-5 6.195E-4 4.607E-3 2.974E-2 3 263
49 hsa-miR-183:PITA hsa-miR-183:PITA TOP PITA 3.195E-5 6.207E-4 4.616E-3 3.041E-2 3 265
50 hsa-miR-891b:PITA hsa-miR-891b:PITA TOP PITA 3.303E-5 6.290E-4 4.677E-3 3.145E-2 3 268
Show 45 more annotations

17: Drug [Display Chart] 17 input genes in category / 5286 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID005289333 1,3,2-dioxaborolan-2-ol Stitch 2.501E-25 1.322E-21 1.210E-20 1.322E-21 12 104
2 CID009549240 3 tp Stitch 5.946E-25 1.571E-21 1.438E-20 3.143E-21 11 66
3 CID000073965 MW 1 Stitch 2.685E-23 4.730E-20 4.328E-19 1.419E-19 12 151
4 CID000005293 AC1L1K15 Stitch 6.342E-22 8.380E-19 7.668E-18 3.352E-18 11 120
5 CID000434448 NSC350854 Stitch 6.893E-20 7.288E-17 6.668E-16 3.644E-16 10 108
6 CID000452221 AC1L9Q5W Stitch 3.860E-15 3.401E-12 3.112E-11 2.040E-11 8 106
7 CID003030073 ap1-6 Stitch 3.989E-12 3.012E-9 2.756E-8 2.109E-8 5 23
8 ctd:C037032 galangin CTD 6.699E-12 4.426E-9 4.050E-8 3.541E-8 6 68
9 CID005289552 alpha-D-glucose 1-phosphate 6-vanadate Stitch 3.289E-11 1.932E-8 1.768E-7 1.739E-7 6 88
10 CID000032842 MDPC Stitch 6.778E-11 3.583E-8 3.278E-7 3.583E-7 5 39
11 CID000123280 lanthanum carbide Stitch 8.081E-10 3.883E-7 3.553E-6 4.272E-6 4 19
12 CID004184747 AC1N4UEG Stitch 1.010E-9 4.447E-7 4.070E-6 5.337E-6 4 20
13 CID004620597 Bmps Stitch 1.306E-9 5.310E-7 4.858E-6 6.902E-6 5 69
14 CID010316032 SD-208 Stitch 1.843E-9 6.958E-7 6.366E-6 9.741E-6 4 23
15 CID009858940 SB-505124 Stitch 4.251E-9 1.498E-6 1.371E-5 2.247E-5 4 28
16 CID000030819 phosphotyrosine (pY Stitch 5.221E-9 1.725E-6 1.578E-5 2.760E-5 6 203
17 CID000200884 P-15 Stitch 8.917E-9 2.773E-6 2.537E-5 4.714E-5 6 222
18 CID003080785 Mcat Stitch 1.084E-8 3.182E-6 2.912E-5 5.728E-5 4 35
19 ctd:C022909 5-methoxypsoralen CTD 1.196E-8 3.328E-6 3.045E-5 6.324E-5 3 7
20 CID000005637 U0126 Stitch 1.341E-8 3.543E-6 3.242E-5 7.086E-5 7 431
21 ctd:C554430 LDN 193189 CTD 1.913E-8 4.816E-6 4.407E-5 1.011E-4 3 8
22 CID000108062 Madecassol Stitch 3.361E-8 7.734E-6 7.076E-5 1.776E-4 4 46
23 CID000005307 A19413 Stitch 3.365E-8 7.734E-6 7.076E-5 1.779E-4 5 131
24 ctd:C530108 LY2109761 CTD 4.096E-8 9.021E-6 8.255E-5 2.165E-4 3 10
25 CID000086322 CP094 Stitch 1.068E-7 2.258E-5 2.066E-4 5.645E-4 5 165
26 CID000079689 polyoxyethylene (10 Stitch 1.217E-7 2.475E-5 2.264E-4 6.434E-4 4 63
27 CID000133445 TAAD Stitch 4.517E-7 8.843E-5 8.091E-4 2.388E-3 3 21
28 CID000454702 AC1L9RT0 Stitch 5.228E-7 9.869E-5 9.030E-4 2.763E-3 3 22
29 CID004369394 AR E Stitch 5.557E-7 1.013E-4 9.269E-4 2.938E-3 5 230
30 ctd:C007350 nitrofen CTD 6.580E-7 1.159E-4 1.061E-3 3.478E-3 5 238
31 ctd:C031534 imperatorin CTD 6.864E-7 1.170E-4 1.071E-3 3.628E-3 3 24
32 ctd:C010845 aluminum chloride CTD 8.531E-7 1.409E-4 1.289E-3 4.509E-3 4 102
33 ctd:C009172 rhodioloside CTD 1.676E-6 2.685E-4 2.456E-3 8.859E-3 3 32
34 CID000104764 monocrotaline pyrrole Stitch 2.408E-6 3.637E-4 3.328E-3 1.273E-2 3 36
35 CID000172416 sodium;hexadecane Stitch 2.408E-6 3.637E-4 3.328E-3 1.273E-2 3 36
36 ctd:D015638 Cytochalasin D CTD 3.078E-6 4.520E-4 4.136E-3 1.627E-2 3 39
37 ctd:C471405 sorafenib CTD 3.875E-6 5.390E-4 4.932E-3 2.048E-2 4 149
38 CID000114813 AC1Q5H8E Stitch 3.875E-6 5.390E-4 4.932E-3 2.048E-2 4 149
39 ctd:C581572 1-trifluoromethoxyphenyl-3-(1-propionylpiperidine-4-yl)urea CTD 6.568E-6 8.902E-4 8.146E-3 3.472E-2 3 50
40 CID009958995 CDDO-Im Stitch 8.297E-6 1.096E-3 1.003E-2 4.386E-2 3 54
41 1006 DN 17-AAG; Down 200; 1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 9.935E-6 1.237E-3 1.132E-2
5.251E-2
 4 189
42 970 DN 5230742; Down 200; 17uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.057E-5 1.237E-3 1.132E-2
5.588E-2
 4 192
43 1286 DN Prochlorperazine dimaleate [84-02-6]; Down 200; 6.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.057E-5 1.237E-3 1.132E-2
5.588E-2
 4 192
44 2708 DN Hexylcaine hydrochloride [532-76-3]; Down 200; 13.4uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.124E-5 1.237E-3 1.132E-2
5.940E-2
 4 195
45 953 DN radicicol; Down 200; 0.1uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.124E-5 1.237E-3 1.132E-2
5.940E-2
 4 195
46 5385 UP Amoxicillin [26787-78-0]; Up 200; 11uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.124E-5 1.237E-3 1.132E-2
5.940E-2
 4 195
47 5824 UP Meropenem [96036-03-2]; Up 200; 10.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.147E-5 1.237E-3 1.132E-2
6.061E-2
 4 196
48 5525 DN Cyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.170E-5 1.237E-3 1.132E-2
6.184E-2
 4 197
49 1487 DN Hydrochlorothiazide [58-93-5]; Down 200; 13.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.170E-5 1.237E-3 1.132E-2
6.184E-2
 4 197
50 CID000025476 Hypertensin II Stitch 1.173E-5 1.237E-3 1.132E-2
6.199E-2
 5 429
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 734 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0023643 Lichen disease DisGeNET BeFree 9.577E-9 7.030E-6 5.045E-5 7.030E-6 3 5
2 C0011644 Scleroderma DisGeNET Curated 1.932E-8 7.090E-6 5.088E-5 1.418E-5 6 180
3 C0152021 Congenital heart disease DisGeNET Curated 6.330E-8 1.549E-5 1.111E-4 4.646E-5 5 106
4 C0153690 Secondary malignant neoplasm of bone DisGeNET BeFree 5.619E-7 9.480E-5 6.803E-4 4.124E-4 6 318
5 C0431109 Choroid Plexus Carcinoma DisGeNET Curated 7.749E-7 9.480E-5 6.803E-4 5.688E-4 3 18
6 C0030848 Peyronie Disease DisGeNET Curated 7.749E-7 9.480E-5 6.803E-4 5.688E-4 3 18
7 OMIN:178600 PULMONARY HYPERTENSION, PRIMARY, 1; PPH1 OMIM 1.036E-6 1.010E-4 7.250E-4 7.603E-4 2 2
8 C0151650 Renal fibrosis DisGeNET BeFree 1.101E-6 1.010E-4 7.250E-4 8.082E-4 5 188
9 C0345893 Juvenile polyposis syndrome DisGeNET Curated 2.762E-6 2.252E-4 1.616E-3 2.027E-3 3 27
10 C1867423 Vascular resistance pulmonary increased DisGeNET Curated 3.106E-6 2.280E-4 1.636E-3 2.280E-3 2 3
11 C1844813 Widely spaced teeth DisGeNET Curated 4.233E-6 2.825E-4 2.027E-3 3.107E-3 3 31
12 C0007113 Rectal Carcinoma DisGeNET BeFree 5.407E-6 3.307E-4 2.373E-3 3.969E-3 5 260
13 C3203102 Idiopathic pulmonary arterial hypertension DisGeNET Curated 7.491E-6 4.229E-4 3.035E-3 5.498E-3 5 278
14 C0016037 Fibrodysplasia Ossificans Progressiva DisGeNET Curated 9.974E-6 5.059E-4 3.631E-3 7.321E-3 3 41
15 C0600519 Ventricular Remodeling DisGeNET Curated 1.034E-5 5.059E-4 3.631E-3 7.589E-3 2 5
16 C0018206 granulosa cell tumor DisGeNET BeFree 1.511E-5 6.692E-4 4.803E-3 1.109E-2 3 47
17 C1321551 Shprintzen-Goldberg syndrome DisGeNET Curated 1.550E-5 6.692E-4 4.803E-3 1.138E-2 2 6
18 C0018818 Ventricular Septal Defects DisGeNET Curated 2.559E-5 1.044E-3 7.489E-3 1.879E-2 4 171
19 C0340613 Arterial aneurysm DisGeNET BeFree 4.638E-5 1.792E-3 1.286E-2 3.405E-2 2 10
20 C0029417 Osteoblastoma DisGeNET BeFree 5.666E-5 2.079E-3 1.492E-2 4.159E-2 2 11
21 C0036631 Seminoma DisGeNET Curated 6.609E-5 2.310E-3 1.658E-2 4.851E-2 4 218
22 C0220620 Gastrointestinal Carcinoid Tumor DisGeNET BeFree 7.733E-5 2.580E-3 1.852E-2
5.676E-2
 4 227
23 C1705254 Neonatal Deformity DisGeNET BeFree 1.232E-4 3.933E-3 2.822E-2
9.045E-2
 2 16
24 C0597984 Biliary stricture DisGeNET BeFree 1.396E-4 4.269E-3 3.063E-2
1.024E-1
 2 17
25 C0023267 Fibroid Tumor DisGeNET Curated 1.937E-4 5.495E-3 3.943E-2
1.422E-1
 4 288
26 C4020848 Aneurysmal disease DisGeNET Curated 1.946E-4 5.495E-3 3.943E-2
1.429E-1
 2 20
27 C0039445 Hereditary hemorrhagic telangiectasia DisGeNET Curated 2.150E-4 5.845E-3 4.194E-2
1.578E-1
 2 21
28 C0340543 Familial primary pulmonary hypertension DisGeNET Curated 2.363E-4 6.196E-3 4.446E-2
1.735E-1
 2 22
29 C0497247 Increase in blood pressure DisGeNET Curated 3.089E-4 7.817E-3
5.610E-2
2.267E-1
 3 129
30 C1519346 Skin Carcinogenesis DisGeNET BeFree 3.379E-4 8.266E-3
5.932E-2
2.480E-1
 3 133
31 C0042133 Uterine Fibroids DisGeNET Curated 3.774E-4 8.652E-3
6.209E-2
2.770E-1
 4 343
32 C0042373 Vascular Diseases DisGeNET Curated 4.926E-4 8.652E-3
6.209E-2
3.616E-1
 4 368
33 C0034069 Pulmonary Fibrosis DisGeNET Curated 5.289E-4 8.652E-3
6.209E-2
3.882E-1
 4 375
34 C0003492 Aortic coarctation DisGeNET Curated 7.502E-4 8.652E-3
6.209E-2
5.507E-1
 2 39
35 C2973725 Pulmonary arterial hypertension DisGeNET Curated 7.892E-4 8.652E-3
6.209E-2
5.793E-1
 2 40
36 C0039446 Telangiectasis DisGeNET Curated 7.892E-4 8.652E-3
6.209E-2
5.793E-1
 2 40
37 C0376634 Craniofacial Abnormalities DisGeNET Curated 8.573E-4 8.652E-3
6.209E-2
6.293E-1
 3 183
38 C0346957 Disseminated Malignant Neoplasm DisGeNET BeFree 8.710E-4 8.652E-3
6.209E-2
6.393E-1
 3 184
39 C0685409 Congenital Camptodactyly DisGeNET Curated 9.120E-4 8.652E-3
6.209E-2
6.694E-1
 2 43
40 C0239946 Fibrosis, Liver DisGeNET Curated 9.153E-4 8.652E-3
6.209E-2
6.718E-1
 4 434
41 C0030297 Pancreatic Neoplasm DisGeNET Curated 9.311E-4 8.652E-3
6.209E-2
6.834E-1
 4 436
42 C0018816 Heart Septal Defects DisGeNET Curated 1.043E-3 8.652E-3
6.209E-2
7.659E-1
 2 46
43 C1867421 Elevated right atrial pressure DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
44 OMIN:612229 COLORECTAL CANCER, SUSCEPTIBILITY TO, 3; CRCS3 OMIM 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
45 C1867424 Pulmonary artery vasoconstriction DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
46 C4023094 Ectopic ossification in ligament tissue DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
47 C4280802 Pulmonary venous occlusion DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
48 C4025303 Enlarged vertebral pedicles DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
49 C1856123 Pulmonary artery sling DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
50 C3805639 Generalized muscle hypertrophy DisGeNET Curated 1.049E-3 8.652E-3
6.209E-2
7.700E-1
 1 1
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