Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc163_6, positive side

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1: GO: Molecular Function [Display Chart] 6 input genes in category / 38 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016763 transferase activity, transferring pentosyl groups 1.317E-4 5.003E-3 2.115E-2 5.003E-3 2 56
2 GO:0052657 guanine phosphoribosyltransferase activity 3.215E-4 6.108E-3 2.582E-2 1.222E-2 1 1
3 GO:0004731 purine-nucleoside phosphorylase activity 6.430E-4 6.108E-3 2.582E-2 2.443E-2 1 2
4 GO:0004422 hypoxanthine phosphoribosyltransferase activity 6.430E-4 6.108E-3 2.582E-2 2.443E-2 1 2
5 GO:0002060 purine nucleobase binding 9.643E-4 7.329E-3 3.099E-2 3.664E-2 1 3
6 GO:0004971 AMPA glutamate receptor activity 1.286E-3 8.142E-3 3.442E-2 4.885E-2 1 4
7 GO:0002054 nucleobase binding 1.607E-3 8.722E-3 3.688E-2
6.106E-2
1 5
8 GO:0030957 Tat protein binding 2.570E-3 1.221E-2
5.161E-2
9.765E-2
1 8
9 GO:0016757 transferase activity, transferring glycosyl groups 3.874E-3 1.586E-2
6.705E-2
1.472E-1
2 307
10 GO:0042301 phosphate ion binding 4.173E-3 1.586E-2
6.705E-2
1.586E-1
1 13
11 GO:0004970 ionotropic glutamate receptor activity 6.094E-3 2.031E-2
8.588E-2
2.316E-1
1 19
12 GO:0005234 extracellularly glutamate-gated ion channel activity 6.414E-3 2.031E-2
8.588E-2
2.437E-1
1 20
13 GO:0050998 nitric-oxide synthase binding 7.054E-3 2.062E-2
8.717E-2
2.680E-1
1 22
14 GO:0008066 glutamate receptor activity 8.651E-3 2.130E-2
9.007E-2
3.287E-1
1 27
15 GO:0022824 transmitter-gated ion channel activity 8.970E-3 2.130E-2
9.007E-2
3.409E-1
1 28
16 GO:0022835 transmitter-gated channel activity 8.970E-3 2.130E-2
9.007E-2
3.409E-1
1 28
17 GO:0031492 nucleosomal DNA binding 9.608E-3 2.148E-2
9.081E-2
3.651E-1
1 30
18 GO:0019894 kinesin binding 1.343E-2 2.835E-2
1.199E-1
5.103E-1
1 42
19 GO:0031491 nucleosome binding 1.438E-2 2.877E-2
1.216E-1
5.466E-1
1 45
20 GO:0005231 excitatory extracellular ligand-gated ion channel activity 1.787E-2 3.396E-2
1.436E-1
6.792E-1
1 56
21 GO:0030594 neurotransmitter receptor activity 2.198E-2 3.906E-2
1.652E-1
8.354E-1
1 69
22 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 2.262E-2 3.906E-2
1.652E-1
8.594E-1
1 71
23 GO:0005230 extracellular ligand-gated ion channel activity 2.419E-2 3.997E-2
1.690E-1
9.193E-1
1 76
24 GO:0031490 chromatin DNA binding 2.702E-2 4.279E-2
1.809E-1
1.000E0
1 85
25 GO:0001158 enhancer sequence-specific DNA binding 2.954E-2 4.489E-2
1.898E-1
1.000E0
1 93
26 GO:0035326 enhancer binding 3.361E-2 4.906E-2
2.074E-1
1.000E0
1 106
27 GO:0005200 structural constituent of cytoskeleton 3.486E-2 4.906E-2
2.074E-1
1.000E0
1 110
Show 22 more annotations

2: GO: Biological Process [Display Chart] 6 input genes in category / 323 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:1901069 guanosine-containing compound catabolic process 8.647E-7 2.793E-4 1.775E-3 2.793E-4 2 5
2 GO:0046130 purine ribonucleoside catabolic process 9.066E-6 7.584E-4 4.821E-3 2.928E-3 2 15
3 GO:0006152 purine nucleoside catabolic process 9.066E-6 7.584E-4 4.821E-3 2.928E-3 2 15
4 GO:0043101 purine-containing compound salvage 1.036E-5 7.584E-4 4.821E-3 3.346E-3 2 16
5 GO:1901070 guanosine-containing compound biosynthetic process 1.174E-5 7.584E-4 4.821E-3 3.792E-3 2 17
6 GO:0042454 ribonucleoside catabolic process 3.025E-5 1.629E-3 1.035E-2 9.772E-3 2 27
7 GO:0009164 nucleoside catabolic process 6.050E-5 2.443E-3 1.553E-2 1.954E-2 2 38
8 GO:0043094 cellular metabolic compound salvage 6.050E-5 2.443E-3 1.553E-2 1.954E-2 2 38
9 GO:1901658 glycosyl compound catabolic process 8.134E-5 2.919E-3 1.856E-2 2.627E-2 2 44
10 GO:1901068 guanosine-containing compound metabolic process 9.694E-5 3.090E-3 1.964E-2 3.131E-2 2 48
11 GO:0006195 purine nucleotide catabolic process 1.052E-4 3.090E-3 1.964E-2 3.399E-2 2 50
12 GO:0072523 purine-containing compound catabolic process 1.370E-4 3.687E-3 2.344E-2 4.424E-2 2 57
13 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
14 GO:0006161 deoxyguanosine catabolic process 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
15 GO:0006149 deoxyinosine catabolic process 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
16 GO:0046115 guanosine catabolic process 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
17 GO:0042453 deoxyguanosine metabolic process 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
18 GO:0006148 inosine catabolic process 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
19 GO:0046094 deoxyinosine metabolic process 3.222E-4 5.336E-3 3.392E-2
1.041E-1
1 1
20 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis 3.498E-4 5.336E-3 3.392E-2
1.130E-1
2 91
21 GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis 3.498E-4 5.336E-3 3.392E-2
1.130E-1
2 91
22 GO:0038094 Fc-gamma receptor signaling pathway 3.811E-4 5.336E-3 3.392E-2
1.231E-1
2 95
23 GO:0002431 Fc receptor mediated stimulatory signaling pathway 3.973E-4 5.336E-3 3.392E-2
1.283E-1
2 97
24 GO:0048010 vascular endothelial growth factor receptor signaling pathway 4.055E-4 5.336E-3 3.392E-2
1.310E-1
2 98
25 GO:0042451 purine nucleoside biosynthetic process 4.392E-4 5.336E-3 3.392E-2
1.419E-1
2 102
26 GO:0046129 purine ribonucleoside biosynthetic process 4.392E-4 5.336E-3 3.392E-2
1.419E-1
2 102
27 GO:0009166 nucleotide catabolic process 4.832E-4 5.336E-3 3.392E-2
1.561E-1
2 107
28 GO:1901292 nucleoside phosphate catabolic process 5.873E-4 5.336E-3 3.392E-2
1.897E-1
2 118
29 GO:0042455 ribonucleoside biosynthetic process 6.174E-4 5.336E-3 3.392E-2
1.994E-1
2 121
30 GO:0006738 nicotinamide riboside catabolic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
31 GO:0006178 guanine salvage 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
32 GO:0008617 guanosine metabolic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
33 GO:0046124 purine deoxyribonucleoside catabolic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
34 GO:0070638 pyridine nucleoside catabolic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
35 GO:0070637 pyridine nucleoside metabolic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
36 GO:0032263 GMP salvage 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
37 GO:0046495 nicotinamide riboside metabolic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
38 GO:0034418 urate biosynthetic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
39 GO:0046099 guanine biosynthetic process 6.443E-4 5.336E-3 3.392E-2
2.081E-1
1 2
40 GO:0009163 nucleoside biosynthetic process 7.231E-4 5.839E-3 3.712E-2
2.336E-1
2 131
41 GO:1901659 glycosyl compound biosynthetic process 7.452E-4 5.871E-3 3.732E-2
2.407E-1
2 133
42 GO:0046122 purine deoxyribonucleoside metabolic process 9.663E-4 6.936E-3 4.409E-2
3.121E-1
1 3
43 GO:0099558 maintenance of synapse structure 9.663E-4 6.936E-3 4.409E-2
3.121E-1
1 3
44 GO:0006168 adenine salvage 9.663E-4 6.936E-3 4.409E-2
3.121E-1
1 3
45 GO:0046038 GMP catabolic process 9.663E-4 6.936E-3 4.409E-2
3.121E-1
1 3
46 GO:0046083 adenine metabolic process 1.288E-3 8.071E-3
5.130E-2
4.161E-1
1 4
47 GO:0046121 deoxyribonucleoside catabolic process 1.288E-3 8.071E-3
5.130E-2
4.161E-1
1 4
48 GO:0046084 adenine biosynthetic process 1.288E-3 8.071E-3
5.130E-2
4.161E-1
1 4
49 GO:0043103 hypoxanthine salvage 1.288E-3 8.071E-3
5.130E-2
4.161E-1
1 4
50 GO:0061743 motor learning 1.288E-3 8.071E-3
5.130E-2
4.161E-1
1 4
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 6 input genes in category / 47 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0044301 climbing fiber 6.295E-4 1.975E-2
8.766E-2
2.959E-2 1 2
2 GO:0032983 kainate selective glutamate receptor complex 1.573E-3 1.975E-2
8.766E-2
7.393E-2
1 5
3 GO:0014069 postsynaptic density 2.142E-3 1.975E-2
8.766E-2
1.007E-1
2 232
4 GO:0099572 postsynaptic specialization 2.142E-3 1.975E-2
8.766E-2
1.007E-1
2 232
5 GO:0097433 dense body 2.202E-3 1.975E-2
8.766E-2
1.035E-1
1 7
6 GO:0060076 excitatory synapse 2.522E-3 1.975E-2
8.766E-2
1.185E-1
2 252
7 GO:0043083 synaptic cleft 3.144E-3 2.111E-2
9.369E-2
1.478E-1
1 10
8 GO:0098793 presynapse 4.564E-3 2.549E-2
1.131E-1
2.145E-1
2 341
9 GO:0043189 H4/H2A histone acetyltransferase complex 5.967E-3 2.549E-2
1.131E-1
2.804E-1
1 19
10 GO:1902562 H4 histone acetyltransferase complex 5.967E-3 2.549E-2
1.131E-1
2.804E-1
1 19
11 GO:0035267 NuA4 histone acetyltransferase complex 5.967E-3 2.549E-2
1.131E-1
2.804E-1
1 19
12 GO:0098794 postsynapse 7.799E-3 3.055E-2
1.356E-1
3.666E-1
2 449
13 GO:0032281 AMPA glutamate receptor complex 9.408E-3 3.401E-2
1.509E-1
4.422E-1
1 30
Show 8 more annotations

4: Human Phenotype [Display Chart] 4 input genes in category / 312 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007325 Generalized dystonia 6.475E-5 2.020E-2
1.277E-1
2.020E-2 2 16

5: Mouse Phenotype [Display Chart] 6 input genes in category / 725 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0010290 increased muscle tumor incidence 1.051E-4 2.896E-2
2.075E-1
7.617E-2
2 28
2 MP:0002947 increased hemangioma incidence 1.291E-4 2.896E-2
2.075E-1
9.363E-2
2 31
3 MP:0002575 increased circulating ketone body level 2.054E-4 2.896E-2
2.075E-1
1.489E-1
2 39
4 MP:0001899 absent long term depression 2.271E-4 2.896E-2
2.075E-1
1.647E-1
2 41
5 MP:0005079 decreased cytotoxic T cell cytolysis 2.990E-4 2.896E-2
2.075E-1
2.168E-1
2 47
6 MP:0013280 abnormal cytotoxic T cell cytolysis 3.119E-4 2.896E-2
2.075E-1
2.261E-1
2 48
7 MP:0003457 abnormal circulating ketone body level 4.099E-4 2.896E-2
2.075E-1
2.972E-1
2 55
8 MP:0001883 increased mammary adenocarcinoma incidence 4.403E-4 2.896E-2
2.075E-1
3.192E-1
2 57
9 MP:0009745 abnormal behavioral response to xenobiotic 4.692E-4 2.896E-2
2.075E-1
3.402E-1
3 304
10 MP:0012592 decreased brain choline acetyltransferase activity 5.794E-4 2.896E-2
2.075E-1
4.201E-1
1 1
11 MP:0011595 abnormal purine-nucleoside phosphorylase activity 5.794E-4 2.896E-2
2.075E-1
4.201E-1
1 1
12 MP:0011597 decreased purine-nucleoside phosphorylase activity 5.794E-4 2.896E-2
2.075E-1
4.201E-1
1 1
13 MP:0020077 decreased tyrosine 3-monooxygenase activity 5.794E-4 2.896E-2
2.075E-1
4.201E-1
1 1
14 MP:0020078 decreased brain tyrosine 3-monooxygenase activity 5.794E-4 2.896E-2
2.075E-1
4.201E-1
1 1
15 MP:0002357 abnormal spleen white pulp morphology 7.398E-4 2.896E-2
2.075E-1
5.364E-1
3 355
16 MP:0002272 abnormal nervous system electrophysiology 7.645E-4 2.896E-2
2.075E-1
5.542E-1
3 359
17 MP:0001362 abnormal anxiety-related response 7.707E-4 2.896E-2
2.075E-1
5.588E-1
3 360
18 MP:0008414 abnormal spatial reference memory 8.240E-4 2.896E-2
2.075E-1
5.974E-1
2 78
19 MP:0002747 abnormal aortic valve morphology 9.325E-4 2.896E-2
2.075E-1
6.761E-1
2 83
20 MP:0005078 abnormal cytotoxic T cell physiology 9.325E-4 2.896E-2
2.075E-1
6.761E-1
2 83
21 MP:0010429 abnormal heart left ventricle outflow tract morphology 9.325E-4 2.896E-2
2.075E-1
6.761E-1
2 83
22 MP:0008428 abnormal spatial working memory 9.325E-4 2.896E-2
2.075E-1
6.761E-1
2 83
23 MP:0001458 abnormal object recognition memory 1.001E-3 2.896E-2
2.075E-1
7.256E-1
2 86
24 MP:0002065 abnormal fear/anxiety-related behavior 1.064E-3 2.896E-2
2.075E-1
7.715E-1
3 402
25 MP:0008083 decreased single-positive T cell number 1.071E-3 2.896E-2
2.075E-1
7.768E-1
2 89
26 MP:0020074 abnormal brain tyrosine 3-monooxygenase activity 1.159E-3 2.896E-2
2.075E-1
8.400E-1
1 2
27 MP:0020168 decreased thyroid gland weight 1.159E-3 2.896E-2
2.075E-1
8.400E-1
1 2
28 MP:0020073 abnormal tyrosine 3-monooxygenase activity 1.159E-3 2.896E-2
2.075E-1
8.400E-1
1 2
29 MP:0012590 decreased choline O-acetyltransferase activity 1.159E-3 2.896E-2
2.075E-1
8.400E-1
1 2
30 MP:0001898 abnormal long term depression 1.245E-3 3.010E-2
2.156E-1
9.029E-1
2 96
31 MP:0008182 decreased marginal zone B cell number 1.350E-3 3.121E-2
2.236E-1
9.791E-1
2 100
32 MP:0010299 increased mammary gland tumor incidence 1.377E-3 3.121E-2
2.236E-1
9.986E-1
2 101
33 MP:0000534 abnormal ureter morphology 1.631E-3 3.394E-2
2.432E-1
1.000E0
2 110
34 MP:0010224 abnormal heart ventricle outflow tract morphology 1.661E-3 3.394E-2
2.432E-1
1.000E0
2 111
35 MP:0002746 abnormal semilunar valve morphology 1.721E-3 3.394E-2
2.432E-1
1.000E0
2 113
36 MP:0011476 abnormal urine nucleotide level 1.737E-3 3.394E-2
2.432E-1
1.000E0
1 3
37 MP:0001417 decreased exploration in new environment 1.781E-3 3.394E-2
2.432E-1
1.000E0
2 115
38 MP:0004392 abnormal CD8-positive, alpha-beta T cell physiology 1.812E-3 3.394E-2
2.432E-1
1.000E0
2 116
39 MP:0005017 decreased B cell number 1.826E-3 3.394E-2
2.432E-1
1.000E0
3 484
40 MP:0012589 abnormal choline O-acetyltransferase activity 2.316E-3 4.029E-2
2.887E-1
1.000E0
1 4
41 MP:0012006 abnormal hippocampus physiology 2.316E-3 4.029E-2
2.887E-1
1.000E0
1 4
42 MP:0002915 abnormal synaptic depression 2.339E-3 4.029E-2
2.887E-1
1.000E0
2 132
43 MP:0008180 abnormal marginal zone B cell morphology 2.445E-3 4.029E-2
2.887E-1
1.000E0
2 135
44 MP:0008081 abnormal single-positive T cell number 2.445E-3 4.029E-2
2.887E-1
1.000E0
2 135
45 MP:0000950 abnormal seizure response to pharmacological agent 2.554E-3 4.114E-2
2.948E-1
1.000E0
2 138
46 MP:0014074 increased brain glycogen level 2.894E-3 4.465E-2
3.199E-1
1.000E0
1 5
47 MP:0005583 decreased renin activity 2.894E-3 4.465E-2
3.199E-1
1.000E0
1 5
48 MP:0002032 increased sarcoma incidence 3.010E-3 4.546E-2
3.257E-1
1.000E0
2 150
49 MP:0002362 abnormal spleen marginal zone morphology 3.333E-3 4.662E-2
3.340E-1
1.000E0
2 158
50 MP:0013189 abnormal exploration in a new environment 3.333E-3 4.662E-2
3.340E-1
1.000E0
2 158
Show 45 more annotations

6: Domain [Display Chart] 6 input genes in category / 44 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR011268 Purine phosphorylase InterPro 3.203E-4 3.522E-3 1.540E-2 1.409E-2 1 1
2 IPR011270 Pur Nuc Pase Ino/Guo-sp InterPro 3.203E-4 3.522E-3 1.540E-2 1.409E-2 1 1
3 PF05994 FragX IP Pfam 6.404E-4 3.522E-3 1.540E-2 2.818E-2 1 2
4 PS01240 PNP MTAP 2 PROSITE 6.404E-4 3.522E-3 1.540E-2 2.818E-2 1 2
5 IPR005904 Hxn phspho trans InterPro 6.404E-4 3.522E-3 1.540E-2 2.818E-2 1 2
6 IPR008081 Cytoplasmic FMR1-int InterPro 6.404E-4 3.522E-3 1.540E-2 2.818E-2 1 2
7 IPR018099 Purine phosphorylase-2 CS InterPro 6.404E-4 3.522E-3 1.540E-2 2.818E-2 1 2
8 IPR001369 PNP/MTAP InterPro 6.404E-4 3.522E-3 1.540E-2 2.818E-2 1 2
9 IPR009828 DUF1394 InterPro 1.281E-3 4.334E-3 1.895E-2
5.634E-2
1 4
10 IPR000845 Nucleoside phosphorylase d InterPro 1.281E-3 4.334E-3 1.895E-2
5.634E-2
1 4
11 3.40.50.1580 - Gene3D 1.281E-3 4.334E-3 1.895E-2
5.634E-2
1 4
12 PF07159 DUF1394 Pfam 1.281E-3 4.334E-3 1.895E-2
5.634E-2
1 4
13 PF01048 PNP UDP 1 Pfam 1.281E-3 4.334E-3 1.895E-2
5.634E-2
1 4
14 PS00103 PUR PYR PR TRANSFER PROSITE 1.600E-3 5.030E-3 2.199E-2
7.042E-2
1 5
15 PS00406 ACTINS 1 PROSITE 2.560E-3 7.508E-3 3.283E-2
1.126E-1
1 8
16 PF00156 Pribosyltran Pfam 3.518E-3 8.726E-3 3.816E-2
1.548E-1
1 11
17 IPR000836 PRibTrfase dom InterPro 3.837E-3 8.726E-3 3.816E-2
1.688E-1
1 12
18 3.40.50.2020 - Gene3D 3.837E-3 8.726E-3 3.816E-2
1.688E-1
1 12
19 IPR029057 PRTase-like InterPro 3.837E-3 8.726E-3 3.816E-2
1.688E-1
1 12
20 IPR004001 Actin CS InterPro 5.114E-3 8.726E-3 3.816E-2
2.250E-1
1 16
21 PS00432 ACTINS 2 PROSITE 5.433E-3 8.726E-3 3.816E-2
2.390E-1
1 17
22 IPR019594 Glu/Gly-bd InterPro 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
23 IPR001508 Iono rcpt met InterPro 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
24 PF10613 Lig chan-Glu bd Pfam 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
25 SM00918 Lig chan-Glu bd SMART 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
26 PF00060 Lig chan Pfam 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
27 SM00079 PBPe SMART 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
28 IPR001320 Iontro rcpt InterPro 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
29 IPR020902 Actin/actin-like CS InterPro 5.752E-3 8.726E-3 3.816E-2
2.531E-1
1 18
30 PS01132 ACTINS ACT LIKE PROSITE 6.070E-3 8.903E-3 3.893E-2
2.671E-1
1 19
31 PF00022 Actin Pfam 9.888E-3 1.283E-2
5.610E-2
4.351E-1
1 31
32 SM00268 ACTIN SMART 9.888E-3 1.283E-2
5.610E-2
4.351E-1
1 31
33 IPR004000 Actin InterPro 9.888E-3 1.283E-2
5.610E-2
4.351E-1
1 31
34 PF00386 C1q Pfam 1.021E-2 1.283E-2
5.610E-2
4.491E-1
1 32
35 SM00110 C1Q SMART 1.021E-2 1.283E-2
5.610E-2
4.491E-1
1 32
36 PS50871 C1Q PROSITE 1.084E-2 1.289E-2
5.637E-2
4.770E-1
1 34
37 IPR001073 C1q dom InterPro 1.084E-2 1.289E-2
5.637E-2
4.770E-1
1 34
38 IPR001828 ANF lig-bd rcpt InterPro 1.179E-2 1.330E-2
5.818E-2
5.189E-1
1 37
39 PF01094 ANF receptor Pfam 1.179E-2 1.330E-2
5.818E-2
5.189E-1
1 37
40 IPR028082 Peripla BP I InterPro 1.243E-2 1.367E-2
5.977E-2
5.468E-1
1 39
41 2.60.120.40 - Gene3D 1.591E-2 1.707E-2
7.465E-2
7.000E-1
1 50
42 IPR008983 Tumour necrosis fac-like dom InterPro 1.843E-2 1.931E-2
8.445E-2
8.111E-1
1 58
43 IPR008160 Collagen InterPro 2.692E-2 2.692E-2
1.177E-1
1.000E0
1 85
44 PF01391 Collagen Pfam 2.692E-2 2.692E-2
1.177E-1
1.000E0
1 85
Show 39 more annotations

7: Pathway [Display Chart] 6 input genes in category / 117 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 547497 guanine and guanosine salvage BioSystems: BIOCYC 1.936E-7 2.265E-5 1.210E-4 2.265E-5 2 2
2 547495 adenine and adenosine salvage III BioSystems: BIOCYC 5.806E-7 3.396E-5 1.815E-4 6.793E-5 2 3
3 P02788 Xanthine and guanine salvage pathway PantherDB 1.161E-6 4.527E-5 2.419E-4 1.358E-4 2 4
4 P02723 Adenine and hypoxanthine salvage pathway PantherDB 4.060E-6 1.188E-4 6.347E-4 4.751E-4 2 7
5 1270136 Purine salvage BioSystems: REACTOME 1.506E-5 3.525E-4 1.883E-3 1.762E-3 2 13
6 SMP00050 Purine Metabolism SMPDB 6.758E-5 1.318E-3 7.042E-3 7.906E-3 2 27
7 1270134 Purine metabolism BioSystems: REACTOME 1.078E-4 1.770E-3 9.461E-3 1.262E-2 2 34
8 1269518 RHO GTPases Activate WASPs and WAVEs BioSystems: REACTOME 1.211E-4 1.770E-3 9.461E-3 1.416E-2 2 36
9 907942 superpathway of purine nucleotide salvage BioSystems: BIOCYC 1.574E-4 2.046E-3 1.093E-2 1.842E-2 2 41
10 1269281 Regulation of actin dynamics for phagocytic cup formation BioSystems: REACTOME 4.607E-4 4.337E-3 2.318E-2
5.390E-2
2 70
11 SMP00365 Gout or Kelley-Seegmiller Syndrome SMPDB 4.819E-4 4.337E-3 2.318E-2
5.639E-2
1 1
12 SMP00210 Purine Nucleoside Phosphorylase Deficiency SMPDB 4.819E-4 4.337E-3 2.318E-2
5.639E-2
1 1
13 SMP00364 Lesch-Nyhan Syndrome (LNS) SMPDB 4.819E-4 4.337E-3 2.318E-2
5.639E-2
1 1
14 MAP00230 Purine metabolism MAP00230 Purine metabolism GenMAPP 6.630E-4 5.541E-3 2.961E-2
7.757E-2
2 84
15 M5493 Genes related to Wnt-mediated signal transduction MSigDB C2 BIOCARTA (v6.0) 7.440E-4 5.803E-3 3.101E-2
8.704E-2
2 89
16 1269279 Fcgamma receptor (FCGR) dependent phagocytosis BioSystems: REACTOME 8.472E-4 6.077E-3 3.248E-2
9.912E-2
2 95
17 1270133 Metabolism of nucleotides BioSystems: REACTOME 8.830E-4 6.077E-3 3.248E-2
1.033E-1
2 97
18 1108783 purine deoxyribonucleosides degradation BioSystems: BIOCYC 9.637E-4 6.264E-3 3.347E-2
1.127E-1
1 2
19 P00029 Huntington disease PantherDB 1.415E-3 7.686E-3 4.107E-2
1.656E-1
2 123
20 142432 purine ribonucleosides degradation to ribose-1-phosphate BioSystems: BIOCYC 1.445E-3 7.686E-3 4.107E-2
1.691E-1
1 3
21 545363 guanosine nucleotides degradation BioSystems: BIOCYC 1.445E-3 7.686E-3 4.107E-2
1.691E-1
1 3
22 142442 arsenate detoxification I (glutaredoxin) BioSystems: BIOCYC 1.445E-3 7.686E-3 4.107E-2
1.691E-1
1 3
23 1268797 Activation of AMPA receptors BioSystems: REACTOME 1.927E-3 9.800E-3
5.237E-2
2.254E-1
1 4
24 82944 Purine metabolism BioSystems: KEGG 2.839E-3 1.352E-2
7.224E-2
3.322E-1
2 175
25 545323 urate biosynthesis/inosine 5'-phosphate degradation BioSystems: BIOCYC 2.889E-3 1.352E-2
7.224E-2
3.380E-1
1 6
26 142279 adenosine nucleotides degradation BioSystems: BIOCYC 3.850E-3 1.733E-2
9.258E-2
4.505E-1
1 8
27 83089 Regulation of actin cytoskeleton BioSystems: KEGG 4.138E-3 1.793E-2
9.582E-2
4.842E-1
2 212
28 1270137 Purine catabolism BioSystems: REACTOME 4.811E-3 1.876E-2
1.003E-1
5.628E-1
1 10
29 545362 purine nucleotides degradation BioSystems: BIOCYC 4.811E-3 1.876E-2
1.003E-1
5.628E-1
1 10
30 1268698 Folding of actin by CCT/TriC BioSystems: REACTOME 4.811E-3 1.876E-2
1.003E-1
5.628E-1
1 10
31 SMP00048 Nicotinate and Nicotinamide Metabolism SMPDB 5.770E-3 2.178E-2
1.164E-1
6.751E-1
1 12
32 1269509 RHO GTPase Effectors BioSystems: REACTOME 7.881E-3 2.810E-2
1.502E-1
9.220E-1
2 295
33 1268796 Trafficking of GluR2-containing AMPA receptors BioSystems: REACTOME 8.166E-3 2.810E-2
1.502E-1
9.555E-1
1 17
34 1268799 Unblocking of NMDA receptor, glutamate binding and activation BioSystems: REACTOME 8.166E-3 2.810E-2
1.502E-1
9.555E-1
1 17
35 1383059 SALM protein interactions at the synapses BioSystems: REACTOME 1.008E-2 3.370E-2
1.801E-1
1.000E0
1 21
36 SMP00046 Pyrimidine Metabolism SMPDB 1.199E-2 3.897E-2
2.082E-1
1.000E0
1 25
37 1268696 Prefoldin mediated transfer of substrate to CCT/TriC BioSystems: REACTOME 1.390E-2 4.279E-2
2.287E-1
1.000E0
1 29
38 83014 Nicotinate and nicotinamide metabolism BioSystems: KEGG 1.390E-2 4.279E-2
2.287E-1
1.000E0
1 29
39 1268794 Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity BioSystems: REACTOME 1.533E-2 4.429E-2
2.367E-1
1.000E0
1 32
40 1268795 Trafficking of AMPA receptors BioSystems: REACTOME 1.533E-2 4.429E-2
2.367E-1
1.000E0
1 32
41 138005 E-cadherin signaling in the nascent adherens junction BioSystems: Pathway Interaction Database 1.580E-2 4.429E-2
2.367E-1
1.000E0
1 33
42 1268695 Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding BioSystems: REACTOME 1.628E-2 4.429E-2
2.367E-1
1.000E0
1 34
43 1269507 Signaling by Rho GTPases BioSystems: REACTOME 1.628E-2 4.429E-2
2.367E-1
1.000E0
2 430
44 1309113 DNA Damage Recognition in GG-NER BioSystems: REACTOME 1.865E-2 4.865E-2
2.600E-1
1.000E0
1 39
45 583255 Nicotine addiction BioSystems: KEGG 1.913E-2 4.865E-2
2.600E-1
1.000E0
1 40
46 137918 Stabilization and expansion of the E-cadherin adherens junction BioSystems: Pathway Interaction Database 1.913E-2 4.865E-2
2.600E-1
1.000E0
1 40
47 1268798 Activation of NMDA receptor upon glutamate binding and postsynaptic events BioSystems: REACTOME 1.960E-2 4.879E-2
2.607E-1
1.000E0
1 41
48 1270332 EPHB-mediated forward signaling BioSystems: REACTOME 2.008E-2 4.893E-2
2.615E-1
1.000E0
1 42
49 PW:0000031 purine metabolic Pathway Ontology 2.055E-2 4.907E-2
2.622E-1
1.000E0
1 43
50 MAP00240 Pyrimidine metabolism MAP00240 Pyrimidine metabolism GenMAPP 2.102E-2 4.919E-2
2.629E-1
1.000E0
1 44
Show 45 more annotations

8: Pubmed [Display Chart] 6 input genes in category / 1565 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 22735032 Reference genes in the developing murine brain and in differentiating embryonic stem cells. Pubmed 2.056E-7 1.609E-4 1.276E-3 3.218E-4 2 5
2 22884776 Evaluation of reference genes for quantitative PCR analysis of mouse lymphocytes. Pubmed 2.056E-7 1.609E-4 1.276E-3 3.218E-4 2 5
3 30094508 Identification of reference genes suitable for RT-qPCR studies of murine gastrulation and patterning. Pubmed 5.756E-7 2.413E-4 1.914E-3 9.009E-4 2 8
4 204065 Assignment of the genes for thymidine kinase and galactokinase to Mus musculus chromosome 11 and the preferential segregation of this chromosome in Chinese hamster/mouse somatic cell hybrids. Pubmed 9.250E-7 2.413E-4 1.914E-3 1.448E-3 2 10
5 11964161 Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin. Pubmed 9.250E-7 2.413E-4 1.914E-3 1.448E-3 2 10
6 1235912 Gene linkage analysis in the mouse by somatic cell hybridization: assignment of adenine phosphoribosyltransferase to chromosome 8 and alpha-galactosidase to the X chromosome. Pubmed 9.250E-7 2.413E-4 1.914E-3 1.448E-3 2 10
7 26969129 Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2. Pubmed 1.130E-6 2.527E-4 2.005E-3 1.769E-3 2 11
8 23213437 The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs. Pubmed 2.158E-6 4.221E-4 3.348E-3 3.377E-3 2 15
9 9463375 In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly. Pubmed 2.794E-6 4.373E-4 3.469E-3 4.373E-3 2 17
10 198184 Gene mapping in Mus musculus by interspecific cell hybridization: assignment of the genes for tripeptidase-1 to chromosome 10, dipeptidase-2 to chromosome 18, acid phosphatase-1 to chromosome 12, and adenylate kinase-1 to chromosome 2. Pubmed 2.794E-6 4.373E-4 3.469E-3 4.373E-3 2 17
11 21909369 Global analysis of gene expression in the developing brain of Gtf2ird1 knockout mice. Pubmed 8.334E-6 5.718E-4 4.536E-3 1.304E-2 2 29
12 19041431 Identification of interaction partners for individual SH3 domains of Fas ligand associated members of the PCH protein family in T lymphocytes. Pubmed 9.544E-6 5.718E-4 4.536E-3 1.494E-2 2 31
13 19799774 Molecular networks involved in mouse cerebral corticogenesis and spatio-temporal regulation of Sox4 and Sox11 novel antisense transcripts revealed by transcriptome profiling. Pubmed 4.943E-5 5.718E-4 4.536E-3
7.736E-2
2 70
14 21800051 The interaction between ubiquitin C-terminal hydrolase 37 and glucose-regulated protein 78 in hepatocellular carcinoma. Pubmed 1.011E-4 5.718E-4 4.536E-3
1.582E-1
2 100
15 17651734 An active Src kinase-beta-actin association is linked to actin dynamics at the periphery of colon cancer cells. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
16 17697207 Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
17 19995283 Sequence-specific correction of genomic hypoxanthine-guanine phosphoribosyl transferase mutations in lymphoblasts by small fragment homologous replacement. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
18 26210823 Cytoskeletal regulation of platelet formation: Coordination of F-actin and microtubules. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
19 24794428 Behavioral abnormalities and circuit defects in the basal ganglia of a mouse model of 16p11.2 deletion syndrome. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
20 12874812 Comparative analysis of HPRT mutant frequency in children with cancer. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
21 25136576 Novel hypoxanthine guanine phosphoribosyltransferase gene mutations in Saudi Arabian hyperuricemia patients. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
22 27404508 Product Release Pathways in Human and Plasmodium falciparum Phosphoribosyltransferase. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
23 16685646 A mutation of beta -actin that alters depolymerization dynamics is associated with autosomal dominant developmental malformations, deafness, and dystonia. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
24 22132984 HPRT deficiency: identification of twenty-four novel variants including an unusual deep intronic mutation. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
25 25255767 Molecular mechanisms of disease-related human β-actin mutations p.R183W and p.E364K. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
26 21857658 A new mode of corticothalamic transmission revealed in the Gria4(-/-) model of absence epilepsy. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
27 1528024 Mouse models of hypoxanthine phosphoribosyltransferase deficiency. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
28 9205113 Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion: establishment of new HPRT-deficient mouse embryonic stem cell lines. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
29 22331909 Purinergic signaling in human pluripotent stem cells is regulated by the housekeeping gene encoding hypoxanthine guanine phosphoribosyltransferase. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
30 21780909 Novel mutations in the human HPRT gene. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
31 18281956 Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
32 27914629 Cytoplasmic FMR1-Interacting Protein 2 Is a Major Genetic Factor Underlying Binge Eating. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
33 16028230 Strong and ubiquitous expression of transgenes targeted into the beta-actin locus by Cre/lox cassette replacement. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
34 8931706 Two novel missense and frameshift mutations in exons 5 and 6 of the purine nucleoside phosphorylase (PNP) gene in a severe combined immunodeficiency (SCID) patient. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
35 18938130 Effect of the phosphate substrate on drug-inhibitor binding to human purine nucleoside phosphorylase. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
36 659426 Human hypoxanthine-guanine phosphoribosyltransferase. Evidence for tetrameric structure. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
37 28916757 Muscle pathology from stochastic low level DUX4 expression in an FSHD mouse model. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
38 24496622 The expression of Y-linked Zfy2 in XY mouse oocytes leads to frequent meiosis 2 defects, a high incidence of subsequent early cleavage stage arrest and infertility. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
39 24458642 Single β-actin mRNA detection in neurons reveals a mechanism for regulating its translatability. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
40 11857817 A targeted X-linked CMV-Cre line. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
41 9487115 Asymmetrical localization of mRNAs in enterocytes of human jejunum. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
42 10449408 Increased apoptosis induction by 121F mutant p53. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
43 15571222 Clinical and biochemical manifestations and molecular characterization of the mutation HPRT Jerusalem. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
44 20544511 Methylation status of HPRT1 promoter in HPRT deficiency with normal coding region. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
45 19706768 Mutagenicity and potential carcinogenicity of thiopurine treatment in patients with inflammatory bowel disease. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
46 26204901 Impact of nanosilver on various DNA lesions and HPRT gene mutations - effects of charge and surface coating. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
47 10884411 A DNA enzyme with N-glycosylase activity. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
48 24761428 Targeted CNS Delivery Using Human MiniPromoters and Demonstrated Compatibility with Adeno-Associated Viral Vectors. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
49 18835850 MicroRNA-mediated up-regulation of an alternatively polyadenylated variant of the mouse cytoplasmic {beta}-actin gene. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
50 10407678 Temporal, spatial and tissue-specific expression of a myogenin-lacZ transgene targeted to the Hprt locus in mice. Pubmed 1.571E-4 5.718E-4 4.536E-3
2.459E-1
1 1
Show 45 more annotations

9: Interaction [Display Chart] 6 input genes in category / 524 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NCALD NCALD interactions 1.633E-5 8.556E-3
5.852E-2
8.556E-3 2 19
2 int:WASF3 WASF3 interactions 4.432E-5 1.161E-2
7.942E-2
2.322E-2 2 31
3 int:PSAT1 PSAT1 interactions 8.999E-5 1.277E-2
8.735E-2
4.715E-2 2 44
4 int:SPTBN2 SPTBN2 interactions 1.260E-4 1.277E-2
8.735E-2
6.602E-2
2 52
5 int:WASF2 WASF2 interactions 1.309E-4 1.277E-2
8.735E-2
6.860E-2
2 53
6 int:MTAP MTAP interactions 1.462E-4 1.277E-2
8.735E-2
7.662E-2
2 56
7 int:PLG PLG interactions 2.096E-4 1.569E-2
1.073E-1
1.098E-1
2 67
8 int:WASF1 WASF1 interactions 2.698E-4 1.767E-2
1.209E-1
1.414E-1
2 76
9 int:LMOD1 LMOD1 interactions 6.778E-4 3.946E-2
2.699E-1
3.551E-1
1 2
10 int:PA2G4 PA2G4 interactions 1.088E-3 4.116E-2
2.815E-1
5.702E-1
2 153
11 int:WDYHV1 WDYHV1 interactions 1.102E-3 4.116E-2
2.815E-1
5.776E-1
2 154
12 int:SCN10A SCN10A interactions 1.355E-3 4.116E-2
2.815E-1
7.101E-1
1 4
13 int:MYO18B MYO18B interactions 1.355E-3 4.116E-2
2.815E-1
7.101E-1
1 4
14 int:CYFIP1 CYFIP1 interactions 1.501E-3 4.116E-2
2.815E-1
7.867E-1
2 180
15 int:KCNMA1 KCNMA1 interactions 1.688E-3 4.116E-2
2.815E-1
8.846E-1
2 191
16 int:CDK5R2 CDK5R2 interactions 1.694E-3 4.116E-2
2.815E-1
8.875E-1
1 5
17 int:SLC6A2 SLC6A2 interactions 1.694E-3 4.116E-2
2.815E-1
8.875E-1
1 5
18 int:DNASE1 DNASE1 interactions 2.032E-3 4.116E-2
2.815E-1
1.000E0
1 6
19 int:SNCA SNCA interactions 2.212E-3 4.116E-2
2.815E-1
1.000E0
2 219
20 int:SPTAN1 SPTAN1 interactions 2.272E-3 4.116E-2
2.815E-1
1.000E0
2 222
21 int:SDCBP SDCBP interactions 2.312E-3 4.116E-2
2.815E-1
1.000E0
2 224
22 int:UCHL5 UCHL5 interactions 2.333E-3 4.116E-2
2.815E-1
1.000E0
2 225
23 int:ABRA ABRA interactions 2.370E-3 4.116E-2
2.815E-1
1.000E0
1 7
24 int:PCYT1B PCYT1B interactions 2.370E-3 4.116E-2
2.815E-1
1.000E0
1 7
25 int:IFI6 IFI6 interactions 2.709E-3 4.116E-2
2.815E-1
1.000E0
1 8
26 int:RIBIN RIBIN interactions 2.709E-3 4.116E-2
2.815E-1
1.000E0
1 8
27 int:HTR1E HTR1E interactions 3.047E-3 4.116E-2
2.815E-1
1.000E0
1 9
28 int:NYAP1 NYAP1 interactions 3.047E-3 4.116E-2
2.815E-1
1.000E0
1 9
29 int:SCGB1A1 SCGB1A1 interactions 3.047E-3 4.116E-2
2.815E-1
1.000E0
1 9
30 int:FPR1 FPR1 interactions 3.047E-3 4.116E-2
2.815E-1
1.000E0
1 9
31 int:NYAP2 NYAP2 interactions 3.385E-3 4.116E-2
2.815E-1
1.000E0
1 10
32 int:PROM1 PROM1 interactions 3.385E-3 4.116E-2
2.815E-1
1.000E0
1 10
33 int:ACE ACE interactions 3.385E-3 4.116E-2
2.815E-1
1.000E0
1 10
34 int:REG3A REG3A interactions 3.385E-3 4.116E-2
2.815E-1
1.000E0
1 10
35 int:NXF5 NXF5 interactions 3.385E-3 4.116E-2
2.815E-1
1.000E0
1 10
36 int:DLG4 DLG4 interactions 3.436E-3 4.116E-2
2.815E-1
1.000E0
2 274
37 int:MYO16 MYO16 interactions 3.723E-3 4.116E-2
2.815E-1
1.000E0
1 11
38 int:NCKAP1L NCKAP1L interactions 3.723E-3 4.116E-2
2.815E-1
1.000E0
1 11
39 int:NRAP NRAP interactions 3.723E-3 4.116E-2
2.815E-1
1.000E0
1 11
40 int:ECHDC1 ECHDC1 interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
41 int:P2RX7 P2RX7 interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
42 int:HSD17B3 HSD17B3 interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
43 int:CYBB CYBB interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
44 int:HSPB9 HSPB9 interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
45 int:ZNF695 ZNF695 interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
46 int:CDH10 CDH10 interactions 4.061E-3 4.116E-2
2.815E-1
1.000E0
1 12
47 int:SLC12A3 SLC12A3 interactions 4.399E-3 4.116E-2
2.815E-1
1.000E0
1 13
48 int:VSNL1 VSNL1 interactions 4.399E-3 4.116E-2
2.815E-1
1.000E0
1 13
49 int:PHACTR2 PHACTR2 interactions 4.399E-3 4.116E-2
2.815E-1
1.000E0
1 13
50 int:IL1RL2 IL1RL2 interactions 4.399E-3 4.116E-2
2.815E-1
1.000E0
1 13
Show 45 more annotations

10: Cytoband [Display Chart] 6 input genes in category / 6 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 14q13.1 14q13.1 1.557E-3 5.445E-3 1.334E-2 9.342E-3 1 9
2 11q22 11q22 1.903E-3 5.445E-3 1.334E-2 1.142E-2 1 11
3 Xq26.1 Xq26.1 2.767E-3 5.445E-3 1.334E-2 1.660E-2 1 16
4 7p22 7p22 3.630E-3 5.445E-3 1.334E-2 2.178E-2 1 21
5 5q33.3 5q33.3 6.216E-3 7.459E-3 1.828E-2 3.730E-2 1 36
6 17q21 17q21 1.086E-2 1.086E-2 2.660E-2
6.514E-2
1 63
Show 1 more annotation

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 56 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 3 input genes in category / 3 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1200 Glutamate ionotropic receptor AMPA type subunits genenames.org 6.594E-4 1.484E-3 2.720E-3 1.978E-3 1 4
2 929 Actins genenames.org 9.891E-4 1.484E-3 2.720E-3 2.967E-3 1 6
3 1372 C1q and TNF related genenames.org 2.965E-3 2.965E-3 5.436E-3 8.896E-3 1 18

13: Coexpression [Display Chart] 6 input genes in category / 888 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M1687 Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MLg stroma cells (fibroblasts). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.585E-6 3.184E-3 2.345E-2 3.184E-3 3 132
2 M8526 Protein profiles associated with survival in lung adenocarcinoma. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.961E-5 8.709E-3
6.416E-2
1.742E-2 2 27
3 M1572 Up-regulated in the gastrocnemius muscle of aged (30-month) mice subjected to caloric restriction diet since young adulthood. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.037E-5 1.364E-2
1.004E-1
4.473E-2 2 43
4 16699793-Table1 Human pancreas Miyake06 52genes GeneSigDB 6.827E-5 1.364E-2
1.004E-1
6.063E-2
2 50
5 19278812-Table1 Human Leukemia Carlucci09 57genes GeneSigDB 7.678E-5 1.364E-2
1.004E-1
6.818E-2
2 53
6 19074870-SuppTable4a Human StemCell Harris08 490genes GeneSigDB 9.722E-5 1.439E-2
1.060E-1
8.633E-2
3 398
7 M1712 Genes enriched in neurons in the adult mouse brain identified through correlation-based searches seeded with neuron cell-type specific gene expression patterns. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.305E-4 1.534E-2
1.130E-1
1.159E-1
2 69
8 M14728 Genes up-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 6 h time point that were not up-regulated at the previous time point, 4 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.382E-4 1.534E-2
1.130E-1
1.227E-1
2 71
9 12631704-table1 Human StemCell Qi03 534genes GeneSigDB 1.663E-4 1.641E-2
1.209E-1
1.477E-1
3 477
10 M12924 Genes down-regulated in primary granulosa cells in response to forskolin [PubChem=47936]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.124E-4 1.886E-2
1.390E-1
1.886E-1
2 88
11 M4939 Genes correlated with the early tumor onset in the Emu-myc transgenic mouse lymphoma model. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.318E-4 2.444E-2
1.800E-1
2.947E-1
2 110
12 17638893-SuppTable1 Human Breast Larsson07 188genes GeneSigDB 4.992E-4 2.444E-2
1.800E-1
4.433E-1
2 135
13 M5898 Genes involved in DNA repair. MSigDB H: Hallmark Gene Sets (v6.0) 6.157E-4 2.444E-2
1.800E-1
5.467E-1
2 150
14 M2939 Genes down-regulated in CD8 T cells: undergoing deletional tolerance versus activated. MSigDB C7: Immunologic Signatures (v6.0) 8.364E-4 2.444E-2
1.800E-1
7.427E-1
2 175
15 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.541E-4 2.444E-2
1.800E-1
8.472E-1
2 187
16 18317805-Table1 Human Viral Gao08 5genes GeneSigDB 1.037E-3 2.444E-2
1.800E-1
9.208E-1
1 4
17 M7255 Genes down-regulated in thymus subcapsular cortical region versus the whole medulla. MSigDB C7: Immunologic Signatures (v6.0) 1.058E-3 2.444E-2
1.800E-1
9.394E-1
2 197
18 M3899 Genes down-regulated in comparison of dendritic cells (DC) stimulated with CpG DNA (TLR9 agonist) at 16 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 16 h. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.444E-2
1.800E-1
9.584E-1
2 199
19 M9530 Genes down-regulated in skin: wildtype versus IL1R1 [GeneID=3554] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.444E-2
1.800E-1
9.584E-1
2 199
20 M6584 Genes up-regulated in unstimulated monocytes versus macrophages incubated with CSF1 [GeneID=435] at day 7. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.444E-2
1.800E-1
9.584E-1
2 199
21 M5401 Genes up-regulated in comparison of eosinophils versus macrophages. MSigDB C7: Immunologic Signatures (v6.0) 1.079E-3 2.444E-2
1.800E-1
9.584E-1
2 199
22 M5527 Genes down-regulated in comparison of neutrophils versus effector memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
23 M9017 Genes up-regulated in dendritic cells from: lymph node versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
24 M8330 Genes down-regulated in naïve CD4 [GeneID=920] Tcells versus T conv cells. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
25 M3960 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
26 M9455 Genes up-regulated in CD8 T cells: naïve versus effectors at day 6. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
27 M5429 Genes up-regulated in comparison of mast cells versus macrophages. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
28 M9764 Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Th1 versus Ly6c int CXCR5+ [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
29 M5934 Genes encoding proteins involved in processing of drugs and other xenobiotics. MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
30 M4527 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus stimulated CD4 [GeneID=920] Th2 cells at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
31 M8297 Genes down-regulated in B lymphocytes from: peritoneal cavity versus spleen. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
32 M6309 Genes down-regulated in macrophages stimulated by IFNG [GeneID=3458] for 24h: control versus primed by IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
33 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
34 M7016 Genes down-regulated in lymphoid-primed multipotent progenitors versus pro-B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
35 M6256 Genes up-regulated in T cells from CLL (chronic lymphocytic leukemia) patients: CD4 [GeneID=920] versus CD8. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
36 M5811 Genes down-regulated in comparison of untreated macrophages from IRAK4 [GeneID=51135] deficient mice at 4 h versus those treated with LPS (TLR4 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
37 M5848 Genes up-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
38 M7611 Genes up-regulated in memory CD8 T cells: 2' versus 3'. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
39 M8305 Genes up-regulated in activated T cells: CD4 [GeneID=920] versus Va24- NKT. MSigDB C7: Immunologic Signatures (v6.0) 1.090E-3 2.444E-2
1.800E-1
9.680E-1
2 200
40 M8445 Genes positively correlated with amplifications of MYC [GeneID=4609] in SCLC (small cell lung cancer) cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.101E-3 2.444E-2
1.800E-1
9.776E-1
2 201
41 16790086-tableW1 Rat Liver Perez-Carreon06 290genes GeneSigDB 1.425E-3 3.087E-2
2.274E-1
1.000E0
2 229
42 20508912-TABLEa-1 Human Breast Chen10 10genes Rapamycin GeneSigDB 1.555E-3 3.211E-2
2.366E-1
1.000E0
1 6
43 20508912-TABLEa-2 Human Breast Chen10 10genes Temsirolimus GeneSigDB 1.555E-3 3.211E-2
2.366E-1
1.000E0
1 6
44 12406872-Table4 Human Lymphoma Martinez-Climent03 431genes GeneSigDB 1.944E-3 3.924E-2
2.891E-1
1.000E0
2 268
45 M14105 Genes down-regulated in fibroblasts expressing the XP/CS mutant form of ERCC3 [GeneID=2071], after low dose UVC irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.332E-3 4.372E-2
3.221E-1
1.000E0
1 9
46 18451145-Table1a Human StemCell Kumamoto08 10genes UpRegulated GeneSigDB 2.332E-3 4.372E-2
3.221E-1
1.000E0
1 9
47 M1518 Genes up-regulated in response to nutlin-3a [PubChem=216345], an inhibitor of MDM2 [GeneID=4193], in skin fibroblast cultures after knockdown of TP53 [GeneID=7157] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.332E-3 4.372E-2
3.221E-1
1.000E0
1 9
48 19185848-TableS1 Mouse StemCell Read09 438genes GeneSigDB 2.413E-3 4.372E-2
3.221E-1
1.000E0
2 299
49 M123 Genes constituting the PluriNet protein-protein network shared by the pluripotent cells (embryonic stem cells, embryonical carcinomas and induced pluripotent cells). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.413E-3 4.372E-2
3.221E-1
1.000E0
2 299
50 M19745 Genes down-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.558E-3 4.511E-2
3.323E-1
1.000E0
2 308
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 6 input genes in category / 993 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 5 input genes in category / 45 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 6 input genes in category / 281 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-191:mirSVR highEffct hsa-miR-191:mirSVR conserved highEffect-0.5 MicroRNA.org 2.212E-6 6.215E-4 3.864E-3 6.215E-4 3 349
2 hsa-let-7i*:mirSVR highEffct hsa-let-7i*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.822E-5 6.392E-3 3.974E-2 1.917E-2 2 155
3 hsa-miR-548l:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.401E-5 6.392E-3 3.974E-2 2.361E-2 2 172
4 hsa-miR-521:mirSVR highEffct hsa-miR-521:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.098E-5 6.392E-3 3.974E-2 2.557E-2 2 179
5 hsa-miR-600:PITA hsa-miR-600:PITA TOP PITA 1.759E-4 9.136E-3
5.680E-2
4.942E-2 2 249
6 hsa-miR-205:PITA hsa-miR-205:PITA TOP PITA 2.222E-4 9.136E-3
5.680E-2
6.245E-2
2 280
7 hsa-miR-4282:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.433E-4 9.136E-3
5.680E-2
6.836E-2
2 293
8 hsa-miR-196a-5p:Functional MTI Functional MTI miRTarbase 2.601E-4 9.136E-3
5.680E-2
7.309E-2
2 303
9 hsa-miR-24-2*:mirSVR highEffct hsa-miR-24-2*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.407E-4 1.064E-2
6.614E-2
9.574E-2
2 347
10 hsa-miR-337-5p:mirSVR lowEffct hsa-miR-337-5p:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 3.830E-4 1.076E-2
6.691E-2
1.076E-1
2 368
11 hsa-miR-24-1*:mirSVR highEffct hsa-miR-24-1*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.498E-4 1.149E-2
7.144E-2
1.264E-1
2 399
12 hsa-miR-874:mirSVR highEffct hsa-miR-874:mirSVR conserved highEffect-0.5 MicroRNA.org 4.910E-4 1.150E-2
7.149E-2
1.380E-1
2 417
13 hsa-miR-555:mirSVR highEffct hsa-miR-555:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.737E-4 1.226E-2
7.625E-2
1.612E-1
2 451
14 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.253E-4 1.226E-2
7.625E-2
1.757E-1
2 471
15 hsa-miR-541:mirSVR highEffct hsa-miR-541:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.547E-4 1.226E-2
7.625E-2
1.840E-1
2 482
16 hsa-let-7i-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.303E-4 1.458E-2
9.066E-2
2.333E-1
1 10
17 hsa-miR-3912-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.245E-3 2.058E-2
1.280E-1
3.499E-1
1 15
18 hsa-miR-524-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.328E-3 2.073E-2
1.289E-1
3.732E-1
1 16
19 hsa-miR-525-3p:Functional MTI Functional MTI miRTarbase 1.660E-3 2.455E-2
1.526E-1
4.665E-1
1 20
20 hsa-miR-191-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.075E-3 2.814E-2
1.750E-1
5.830E-1
1 25
21 hsa-miR-604:PITA hsa-miR-604:PITA TOP PITA 2.406E-3 2.814E-2
1.750E-1
6.762E-1
1 29
22 hsa-miR-3146:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.489E-3 2.814E-2
1.750E-1
6.995E-1
1 30
23 hsa-miR-1295a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.489E-3 2.814E-2
1.750E-1
6.995E-1
1 30
24 hsa-miR-6876-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.235E-3 2.814E-2
1.750E-1
9.090E-1
1 39
25 hsa-miR-626:Non-Functional MTI Non-Functional MTI miRTarbase 3.401E-3 2.814E-2
1.750E-1
9.556E-1
1 41
26 hsa-miR-6772-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.483E-3 2.814E-2
1.750E-1
9.788E-1
1 42
27 hsa-miR-6510-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.394E-3 2.814E-2
1.750E-1
1.000E0
1 53
28 hsa-miR-4509:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.725E-3 2.814E-2
1.750E-1
1.000E0
1 57
29 hsa-miR-491-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.808E-3 2.814E-2
1.750E-1
1.000E0
1 58
30 hsa-miR-651-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.387E-3 2.814E-2
1.750E-1
1.000E0
1 65
31 hsa-miR-325:PITA hsa-miR-325:PITA TOP PITA 5.387E-3 2.814E-2
1.750E-1
1.000E0
1 65
32 hsa-miR-4699-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.552E-3 2.814E-2
1.750E-1
1.000E0
1 67
33 hsa-miR-432-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.814E-2
1.750E-1
1.000E0
1 69
34 hsa-miR-4744:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.717E-3 2.814E-2
1.750E-1
1.000E0
1 69
35 hsa-miR-4504:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.800E-3 2.814E-2
1.750E-1
1.000E0
1 70
36 hsa-miR-4289:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.048E-3 2.814E-2
1.750E-1
1.000E0
1 73
37 hsa-miR-6870-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.131E-3 2.814E-2
1.750E-1
1.000E0
1 74
38 hsa-miR-5702:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.213E-3 2.814E-2
1.750E-1
1.000E0
1 75
39 hsa-miR-5572:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 2.814E-2
1.750E-1
1.000E0
1 77
40 hsa-miR-4260:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 2.814E-2
1.750E-1
1.000E0
1 77
41 hsa-miR-382-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.709E-3 2.814E-2
1.750E-1
1.000E0
1 81
42 hsa-miR-5195-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 2.814E-2
1.750E-1
1.000E0
1 83
43 hsa-miR-371-3p:mirSVR highEffct hsa-miR-371-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.874E-3 2.814E-2
1.750E-1
1.000E0
1 83
44 hsa-miR-937-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.874E-3 2.814E-2
1.750E-1
1.000E0
1 83
45 hsa-miR-6738-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.957E-3 2.814E-2
1.750E-1
1.000E0
1 84
46 hsa-miR-1225-5p:PITA hsa-miR-1225-5p:PITA TOP PITA 7.204E-3 2.814E-2
1.750E-1
1.000E0
1 87
47 hsa-miR-493-3p:Functional MTI Functional MTI miRTarbase 7.287E-3 2.814E-2
1.750E-1
1.000E0
1 88
48 hsa-miR-4464:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.369E-3 2.814E-2
1.750E-1
1.000E0
1 89
49 hsa-miR-4748:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.452E-3 2.814E-2
1.750E-1
1.000E0
1 90
50 hsa-miR-126:mirSVR lowEffct hsa-miR-126:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 7.535E-3 2.814E-2
1.750E-1
1.000E0
1 91
Show 45 more annotations

17: Drug [Display Chart] 6 input genes in category / 2242 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000100599 3,7-dideazaguanine Stitch 5.751E-8 1.289E-4 1.069E-3 1.289E-4 2 2
2 CID000073069 C5H5N5O2 Stitch 1.725E-7 1.934E-4 1.604E-3 3.867E-4 2 3
3 CID000409610 AC1L8XA0 Stitch 3.450E-7 2.578E-4 2.138E-3 7.734E-4 2 4
4 CID004023632 6-thioxanthosine Stitch 5.749E-7 3.222E-4 2.672E-3 1.289E-3 2 5
5 CID000466061 AC1LACVZ Stitch 8.622E-7 3.866E-4 3.206E-3 1.933E-3 2 6
6 CID003000603 beta-TGdR Stitch 1.207E-6 4.510E-4 3.740E-3 2.706E-3 2 7
7 CID000095995 8-azaguanosine Stitch 1.609E-6 5.153E-4 4.273E-3 3.607E-3 2 8
8 CID000107502 5'-iodo-5'-deoxyadenosine Stitch 2.069E-6 5.153E-4 4.273E-3 4.638E-3 2 9
9 CID003035973 5-Iodoribose 1-phosphate Stitch 2.069E-6 5.153E-4 4.273E-3 4.638E-3 2 9
10 CID000501523 ACVDP Stitch 2.585E-6 5.796E-4 4.807E-3 5.796E-3 2 10
11 CID000408612 AC1L8V5N Stitch 3.159E-6 5.903E-4 4.895E-3 7.084E-3 2 11
12 CID006332324 AC1O3MP2 Stitch 3.159E-6 5.903E-4 4.895E-3 7.084E-3 2 11
13 CID001268107 6-thioxanthine Stitch 3.791E-6 6.071E-4 5.034E-3 8.499E-3 2 12
14 CID000124316 3-deazaguanosine Stitch 3.791E-6 6.071E-4 5.034E-3 8.499E-3 2 12
15 CID000128476 AICAR triphosphate Stitch 4.480E-6 6.277E-4 5.205E-3 1.004E-2 2 13
16 CID000065125 1H-1,2,4-triazole-3-carboxamide Stitch 4.480E-6 6.277E-4 5.205E-3 1.004E-2 2 13
17 CID003034646 6-thioguanine nucleotide Stitch 5.226E-6 6.892E-4 5.715E-3 1.172E-2 2 14
18 CID000096410 8-azaadenosine Stitch 9.814E-6 1.222E-3 1.014E-2 2.200E-2 2 19
19 CID000001299 AC1L1B62 Stitch 1.205E-5 1.422E-3 1.179E-2 2.701E-2 2 21
20 CID000410238 AC1L8YNX Stitch 1.451E-5 1.627E-3 1.349E-2 3.254E-2 2 23
21 CID000005901 6-azauridine Stitch 2.167E-5 2.314E-3 1.919E-2 4.859E-2 2 28
22 CID000092751 orotidine Stitch 2.665E-5 2.598E-3 2.154E-2
5.975E-2
2 31
23 CID003000241 6-mercaptopurine Deriv. Stitch 2.665E-5 2.598E-3 2.154E-2
5.975E-2
2 31
24 CID000001190 xanthosine 5'-phosphate Stitch 2.842E-5 2.609E-3 2.163E-2
6.372E-2
2 32
25 CID000009570 MMPR Stitch 3.025E-5 2.609E-3 2.163E-2
6.783E-2
2 33
26 CID000407005 5H-purine-2,6-diamine Stitch 3.025E-5 2.609E-3 2.163E-2
6.783E-2
2 33
27 CID000001134 deoxythymidin Stitch 3.398E-5 2.729E-3 2.263E-2
7.618E-2
3 276
28 CID000676166 thioinosine Stitch 3.408E-5 2.729E-3 2.263E-2
7.642E-2
2 35
29 CID002724387 6-thioguanosine Stitch 3.608E-5 2.790E-3 2.313E-2
8.090E-2
2 36
30 CID000096849 8-aminoguanosine Stitch 4.026E-5 3.009E-3 2.495E-2
9.026E-2
2 38
31 CID000000320 NSC277817 Stitch 5.665E-5 3.969E-3 3.291E-2
1.270E-1
2 45
32 CID005473386 AC1NV8O5 Stitch 5.665E-5 3.969E-3 3.291E-2
1.270E-1
2 45
33 CID003330139 AC1MNMOM Stitch 6.452E-5 4.383E-3 3.635E-2
1.447E-1
2 48
34 CID000407007 AC1L8RPE Stitch 7.581E-5 4.601E-3 3.815E-2
1.700E-1
2 52
35 CID000000968 orotidine5-phosphate Stitch 8.487E-5 4.601E-3 3.815E-2
1.903E-1
2 55
36 CID000452109 6-OxaMyr Stitch 8.487E-5 4.601E-3 3.815E-2
1.903E-1
2 55
37 CID000000639 2-deoxyinosine Stitch 1.011E-4 4.601E-3 3.815E-2
2.267E-1
2 60
38 CID000011361 7-methylguanine Stitch 1.011E-4 4.601E-3 3.815E-2
2.267E-1
2 60
39 CID000001074 1-o-phosphonopentofuranose Stitch 1.045E-4 4.601E-3 3.815E-2
2.343E-1
2 61
40 ctd:C000621033 napabucasin CTD 1.151E-4 4.601E-3 3.815E-2
2.580E-1
2 64
41 CID000667490 6-mercaptopurine Stitch 1.582E-4 4.601E-3 3.815E-2
3.547E-1
2 75
42 CID000001189 NSC18930 Stitch 1.668E-4 4.601E-3 3.815E-2
3.740E-1
2 77
43 CID005469591 NSC-690579 Stitch 1.668E-4 4.601E-3 3.815E-2
3.740E-1
2 77
44 CID000008646 8-azaguanine Stitch 1.712E-4 4.601E-3 3.815E-2
3.837E-1
2 78
45 CID000193585 Ino-Hcy Stitch 1.938E-4 4.601E-3 3.815E-2
4.346E-1
2 83
46 CID005473385 Thioguanine (usan Stitch 1.986E-4 4.601E-3 3.815E-2
4.452E-1
2 84
47 CID000001044 purin Stitch 2.081E-4 4.601E-3 3.815E-2
4.666E-1
2 86
48 CID000003206 EHNA Stitch 2.130E-4 4.601E-3 3.815E-2
4.776E-1
2 87
49 CID000000646 AC1Q6S3Y Stitch 2.280E-4 4.601E-3 3.815E-2
5.111E-1
2 90
50 CID000100788 Araf-TC Stitch 2.487E-4 4.601E-3 3.815E-2
5.575E-1
2 94
Show 45 more annotations

18: Disease [Display Chart] 6 input genes in category / 370 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0263912 Rotator cuff syndrome DisGeNET BeFree 1.142E-6 4.225E-4 2.743E-3 4.225E-4 2 5
2 C0796154 SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 DisGeNET Curated 2.630E-5 4.866E-3 3.159E-2 9.733E-3 2 22
3 C0086942 Rous Sarcoma DisGeNET BeFree 1.503E-4 6.524E-3 4.235E-2
5.559E-2
2 52
4 C0848332 Spots on skin DisGeNET BeFree 1.687E-4 6.524E-3 4.235E-2
6.241E-2
3 336
5 C0004135 Ataxia Telangiectasia DisGeNET Curated 2.973E-4 6.524E-3 4.235E-2
1.100E-1
3 407
6 C0015230 Exanthema DisGeNET Curated 3.285E-4 6.524E-3 4.235E-2
1.215E-1
3 421
7 OMIN:607371 DYSTONIA, JUVENILE-ONSET OMIM 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
8 OMIN:613179 PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY OMIM 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
9 C1846331 Juvenile-onset dystonia DisGeNET Curated 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
10 cv:C0268125 Purine-nucleoside phosphorylase deficiency Clinical Variations 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
11 C1834098 Markedly reduced T cell function DisGeNET Curated 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
12 cv:C1846331 Juvenile-onset dystonia Clinical Variations 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
13 C0268104 Disorder of purine metabolism DisGeNET BeFree 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
14 C1849242 Reduced B cell function DisGeNET Curated 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
15 C1959897 Alcohol consumption during pregnancy DisGeNET Curated 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
16 cv:C0268117 Partial hypoxanthine-guanine phosphoribosyltransferase deficiency Clinical Variations 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
17 C0221168 Podagra DisGeNET Curated 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
18 C0238051 Cerebral Angiitis DisGeNET Curated 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
19 C1853623 Fryns-Aftimos Syndrome DisGeNET BeFree 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
20 cv:C0023374 Lesch-Nyhan syndrome Clinical Variations 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
21 cv:C1855722 Iris coloboma with ptosis, hypertelorism, and mental retardation Clinical Variations 3.703E-4 6.524E-3 4.235E-2
1.370E-1
1 1
22 C1848954 Generalized dystonia DisGeNET Curated 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
23 C1837819 Cerebrofrontofacial Syndrome DisGeNET BeFree 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
24 C1846339 Externally rotated hips DisGeNET Curated 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
25 C2712360 Severe hypoxic ischemic encephalopathy DisGeNET BeFree 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
26 C1855722 Iris Coloboma with Ptosis, Hypertelorism, and Mental Retardation DisGeNET Curated 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
27 C1865377 Small lymph nodes DisGeNET Curated 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
28 C4025683 Lymph node hypoplasia DisGeNET Curated 7.404E-4 9.542E-3
6.194E-2
2.739E-1
1 2
29 C0026106 Mild Mental Retardation DisGeNET Curated 7.479E-4 9.542E-3
6.194E-2
2.767E-1
2 116
30 C0024312 Lymphopenia DisGeNET Curated 8.000E-4 9.867E-3
6.406E-2
2.960E-1
2 120
31 C0014040 Encephalitis Lethargica DisGeNET BeFree 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
32 C0235419 hyperuricemic nephropathy DisGeNET BeFree 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
33 C0268117 Gout, HPRT-Related DisGeNET Curated 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
34 C0013393 Dysostoses DisGeNET Curated 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
35 C1697450 Prominent epicanthal folds DisGeNET Curated 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
36 C0948643 Uric acid concentration in urine above normal DisGeNET Curated 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
37 C1291317 Deficiency of transferase DisGeNET BeFree 1.110E-3 1.088E-2
7.065E-2
4.109E-1
1 3
38 C0025007 Measles DisGeNET Curated 1.118E-3 1.088E-2
7.065E-2
4.135E-1
2 142
39 C0011168 Deglutition Disorders DisGeNET Curated 1.165E-3 1.105E-2
7.175E-2
4.310E-1
2 145
40 C1854301 Motor delay DisGeNET Curated 1.262E-3 1.139E-2
7.396E-2
4.671E-1
2 151
41 C4020874 No development of motor milestones DisGeNET Curated 1.262E-3 1.139E-2
7.396E-2
4.671E-1
2 151
42 C1845526 Mental Retardation, X-Linked 46 DisGeNET Curated 1.480E-3 1.245E-2
8.082E-2
5.477E-1
1 4
43 C0268125 Purine-nucleoside phosphorylase deficiency DisGeNET Curated 1.480E-3 1.245E-2
8.082E-2
5.477E-1
1 4
44 C4076349 Chronic alcoholic liver disease DisGeNET BeFree 1.480E-3 1.245E-2
8.082E-2
5.477E-1
1 4
45 C0017083 Gangliosidoses DisGeNET BeFree 1.850E-3 1.456E-2
9.456E-2
6.846E-1
1 5
46 C0340971 Autoimmune neutropenia DisGeNET Curated 1.850E-3 1.456E-2
9.456E-2
6.846E-1
1 5
47 C1832324 Frequent opportunistic infections DisGeNET Curated 1.850E-3 1.456E-2
9.456E-2
6.846E-1
1 5
48 C1305904 Familial hematuria DisGeNET BeFree 2.220E-3 1.676E-2
1.088E-1
8.213E-1
1 6
49 C0268226 Type I Mucolipidosis DisGeNET BeFree 2.220E-3 1.676E-2
1.088E-1
8.213E-1
1 6
50 C0013421 Dystonia DisGeNET Curated 2.445E-3 1.808E-2
1.174E-1
9.048E-1
2 211
Show 45 more annotations