Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc166_10, positive side

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1: GO: Molecular Function [Display Chart] 9 input genes in category / 19 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005344 oxygen carrier activity 7.906E-22 1.502E-20 5.329E-20 1.502E-20 7 14
2 GO:0019825 oxygen binding 2.658E-17 2.525E-16 8.957E-16 5.050E-16 7 51
3 GO:0020037 heme binding 2.543E-14 1.610E-13 5.713E-13 4.831E-13 7 131
4 GO:0046906 tetrapyrrole binding 4.088E-14 1.942E-13 6.889E-13 7.768E-13 7 140
5 GO:0005506 iron ion binding 1.107E-13 4.208E-13 1.493E-12 2.104E-12 7 161
6 GO:0031720 haptoglobin binding 7.757E-11 2.105E-10 7.470E-10 1.474E-9 3 3
7 GO:0031721 hemoglobin alpha binding 7.757E-11 2.105E-10 7.470E-10 1.474E-9 3 3
8 GO:0030492 hemoglobin binding 4.339E-9 1.030E-8 3.656E-8 8.244E-8 3 8
9 GO:0004601 peroxidase activity 1.090E-6 2.300E-6 8.161E-6 2.070E-5 3 45
10 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 1.245E-6 2.365E-6 8.389E-6 2.365E-5 3 47
11 GO:0016209 antioxidant activity 5.358E-6 9.255E-6 3.283E-5 1.018E-4 3 76
12 GO:0031722 hemoglobin beta binding 4.823E-4 7.636E-4 2.709E-3 9.163E-3 1 1
13 GO:0043177 organic acid binding 5.724E-3 8.365E-3 2.968E-2
1.087E-1
 2 243
Show 8 more annotations

2: GO: Biological Process [Display Chart] 9 input genes in category / 141 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0015671 oxygen transport 1.503E-21 2.120E-19 1.172E-18 2.120E-19 7 15
2 GO:0015669 gas transport 5.724E-20 4.035E-18 2.231E-17 8.070E-18 7 23
3 GO:0051291 protein heterooligomerization 4.025E-9 1.892E-7 1.046E-6 5.676E-7 5 151
4 GO:0042744 hydrogen peroxide catabolic process 1.786E-7 6.294E-6 3.480E-5 2.518E-5 3 25
5 GO:0048821 erythrocyte development 3.844E-7 1.041E-5 5.757E-5 5.420E-5 3 32
6 GO:0042542 response to hydrogen peroxide 4.430E-7 1.041E-5 5.757E-5 6.247E-5 4 146
7 GO:0015701 bicarbonate transport 1.096E-6 2.208E-5 1.221E-4 1.546E-4 3 45
8 GO:0042743 hydrogen peroxide metabolic process 1.512E-6 2.666E-5 1.474E-4 2.133E-4 3 50
9 GO:0061515 myeloid cell development 3.681E-6 5.514E-5 3.049E-4 5.191E-4 3 67
10 GO:0000302 response to reactive oxygen species 3.911E-6 5.514E-5 3.049E-4 5.514E-4 4 252
11 GO:0072593 reactive oxygen species metabolic process 4.564E-6 5.850E-5 3.235E-4 6.435E-4 4 262
12 GO:0098869 cellular oxidant detoxification 8.106E-6 9.525E-5 5.267E-4 1.143E-3 3 87
13 GO:1990748 cellular detoxification 8.978E-6 9.738E-5 5.384E-4 1.266E-3 3 90
14 GO:0098754 detoxification 1.023E-5 1.031E-4 5.699E-4 1.443E-3 3 94
15 GO:0007596 blood coagulation 1.656E-5 1.394E-4 7.707E-4 2.335E-3 4 363
16 GO:0007599 hemostasis 1.747E-5 1.394E-4 7.707E-4 2.464E-3 4 368
17 GO:0050817 coagulation 1.747E-5 1.394E-4 7.707E-4 2.464E-3 4 368
18 GO:0030218 erythrocyte differentiation 1.779E-5 1.394E-4 7.707E-4 2.509E-3 3 113
19 GO:0034101 erythrocyte homeostasis 2.294E-5 1.703E-4 9.414E-4 3.235E-3 3 123
20 GO:0006979 response to oxidative stress 3.494E-5 2.463E-4 1.362E-3 4.926E-3 4 439
21 GO:0002262 myeloid cell homeostasis 4.070E-5 2.733E-4 1.511E-3 5.739E-3 3 149
22 GO:0009636 response to toxic substance 2.347E-4 1.443E-3 7.980E-3 3.310E-2 3 269
23 GO:1904407 positive regulation of nitric oxide metabolic process 2.513E-4 1.443E-3 7.980E-3 3.543E-2 2 50
24 GO:0045429 positive regulation of nitric oxide biosynthetic process 2.513E-4 1.443E-3 7.980E-3 3.543E-2 2 50
25 GO:0048872 homeostasis of number of cells 2.559E-4 1.443E-3 7.980E-3 3.608E-2 3 277
26 GO:1903428 positive regulation of reactive oxygen species biosynthetic process 3.502E-4 1.878E-3 1.038E-2 4.938E-2 2 59
27 GO:0006898 receptor-mediated endocytosis 3.596E-4 1.878E-3 1.038E-2
5.070E-2
 3 311
28 GO:0045428 regulation of nitric oxide biosynthetic process 4.121E-4 2.075E-3 1.147E-2
5.811E-2
 2 64
29 GO:0006809 nitric oxide biosynthetic process 5.657E-4 2.750E-3 1.521E-2
7.976E-2
 2 75
30 GO:0046209 nitric oxide metabolic process 6.274E-4 2.949E-3 1.631E-2
8.847E-2
 2 79
31 GO:0030099 myeloid cell differentiation 6.866E-4 2.958E-3 1.636E-2
9.681E-2
 3 388
32 GO:1903426 regulation of reactive oxygen species biosynthetic process 6.923E-4 2.958E-3 1.636E-2
9.762E-2
 2 83
33 GO:2001057 reactive nitrogen species metabolic process 6.923E-4 2.958E-3 1.636E-2
9.762E-2
 2 83
34 GO:0001701 in utero embryonic development 8.468E-4 3.512E-3 1.942E-2
1.194E-1
 3 417
35 GO:2000379 positive regulation of reactive oxygen species metabolic process 1.023E-3 4.120E-3 2.278E-2
1.442E-1
 2 101
36 GO:1903409 reactive oxygen species biosynthetic process 1.084E-3 4.245E-3 2.347E-2
1.528E-1
 2 104
37 GO:0015711 organic anion transport 1.140E-3 4.344E-3 2.402E-2
1.607E-1
 3 462
38 GO:0030185 nitric oxide transport 1.449E-3 5.239E-3 2.897E-2
2.043E-1
 1 3
39 GO:0071409 cellular response to cycloheximide 1.449E-3 5.239E-3 2.897E-2
2.043E-1
 1 3
40 GO:2000377 regulation of reactive oxygen species metabolic process 3.095E-3 1.091E-2
6.032E-2
4.364E-1
 2 177
41 GO:0032463 negative regulation of protein homooligomerization 3.379E-3 1.134E-2
6.272E-2
4.764E-1
 1 7
42 GO:0046898 response to cycloheximide 3.379E-3 1.134E-2
6.272E-2
4.764E-1
 1 7
43 GO:0060509 type I pneumocyte differentiation 3.860E-3 1.237E-2
6.840E-2
5.443E-1
 1 8
44 GO:0071499 cellular response to laminar fluid shear stress 3.860E-3 1.237E-2
6.840E-2
5.443E-1
 1 8
45 GO:0048672 positive regulation of collateral sprouting 5.305E-3 1.626E-2
8.991E-2
7.479E-1
 1 11
46 GO:0048671 negative regulation of collateral sprouting 5.305E-3 1.626E-2
8.991E-2
7.479E-1
 1 11
47 GO:0043249 erythrocyte maturation 5.786E-3 1.700E-2
9.398E-2
8.158E-1
 1 12
48 GO:0032460 negative regulation of protein oligomerization 5.786E-3 1.700E-2
9.398E-2
8.158E-1
 1 12
49 GO:0034616 response to laminar fluid shear stress 6.747E-3 1.941E-2
1.074E-1
9.513E-1
 1 14
50 GO:0032462 regulation of protein homooligomerization 7.708E-3 2.174E-2
1.202E-1
1.000E0
 1 16
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 9 input genes in category / 14 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005833 hemoglobin complex 1.573E-22 2.202E-21 7.160E-21 2.202E-21 7 12
2 GO:0044445 cytosolic part 1.396E-12 9.773E-12 3.178E-11 1.955E-11 7 235
3 GO:0031838 haptoglobin-hemoglobin complex 2.911E-10 1.358E-9 4.417E-9 4.075E-9 3 4
4 GO:0072562 blood microparticle 2.725E-9 9.537E-9 3.101E-8 3.815E-8 5 143
5 GO:0071682 endocytic vesicle lumen 4.933E-8 1.381E-7 4.491E-7 6.907E-7 3 17
6 GO:0060205 cytoplasmic vesicle lumen 1.294E-5 2.899E-5 9.427E-5 1.812E-4 3 104
7 GO:0031983 vesicle lumen 1.450E-5 2.899E-5 9.427E-5 2.029E-4 3 108
8 GO:0022627 cytosolic small ribosomal subunit 1.856E-4 3.247E-4 1.056E-3 2.598E-3 2 44
9 GO:0030139 endocytic vesicle 2.098E-4 3.263E-4 1.061E-3 2.937E-3 3 265
10 GO:0015935 small ribosomal subunit 4.979E-4 6.971E-4 2.267E-3 6.971E-3 2 72
11 GO:0022626 cytosolic ribosome 1.352E-3 1.721E-3 5.596E-3 1.893E-2 2 119
12 GO:0044391 ribosomal subunit 2.892E-3 3.374E-3 1.097E-2 4.049E-2 2 175
13 GO:0005840 ribosome 5.147E-3 5.542E-3 1.802E-2
7.205E-2
 2 235
Show 8 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 456 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0011902 Abnormal hemoglobin 3.960E-10 1.750E-7 1.173E-6 1.806E-7 6 130
2 HP:0005511 Heinz body anemia 1.151E-9 1.750E-7 1.173E-6 5.250E-7 3 3
3 HP:0005507 Hemoglobin Barts 1.151E-9 1.750E-7 1.173E-6 5.250E-7 3 3
4 HP:0001935 Microcytic anemia 3.219E-9 3.669E-7 2.459E-6 1.468E-6 5 68
5 HP:0001930 Nonspherocytic hemolytic anemia 4.022E-8 3.668E-6 2.458E-5 1.834E-5 3 7
6 HP:0011904 Persistence of hemoglobin F 1.079E-7 7.028E-6 4.709E-5 4.920E-5 4 45
7 HP:0011903 HbH hemoglobin 1.079E-7 7.028E-6 4.709E-5 4.920E-5 4 45
8 HP:0001891 Iron deficiency anemia 2.849E-7 1.494E-5 1.001E-4 1.299E-4 4 57
9 HP:0000980 Pallor 3.027E-7 1.494E-5 1.001E-4 1.380E-4 6 388
10 HP:0004840 Hypochromic microcytic anemia 3.277E-7 1.494E-5 1.001E-4 1.494E-4 3 13
11 HP:0100603 Toxemia of pregnancy 3.758E-7 1.558E-5 1.044E-4 1.714E-4 4 61
12 HP:0010972 Anemia of inadequate production 6.068E-7 2.306E-5 1.545E-4 2.767E-4 5 191
13 HP:0001931 Hypochromic anemia 6.973E-7 2.446E-5 1.639E-4 3.180E-4 4 71
14 HP:0025409 Abnormal spleen physiology 2.786E-6 8.470E-5 5.676E-4 1.270E-3 4 100
15 HP:0001971 Hypersplenism 2.786E-6 8.470E-5 5.676E-4 1.270E-3 4 100
16 HP:0001900 Increased hemoglobin 3.522E-6 1.004E-4 6.727E-4 1.606E-3 4 106
17 HP:0000451 Triangular nasal tip 4.061E-6 1.029E-4 6.893E-4 1.852E-3 2 3
18 HP:0011907 Reduced alpha/beta synthesis ratio 4.061E-6 1.029E-4 6.893E-4 1.852E-3 2 3
19 HP:0001081 Cholelithiasis 4.554E-6 1.093E-4 7.324E-4 2.077E-3 4 113
20 HP:0005560 Imbalanced hemoglobin synthesis 5.059E-6 1.154E-4 7.730E-4 2.307E-3 4 116
21 HP:0002686 Prenatal maternal abnormality 5.419E-6 1.177E-4 7.884E-4 2.471E-3 4 118
22 HP:0012437 Abnormal gallbladder morphology 6.610E-6 1.311E-4 8.782E-4 3.014E-3 4 124
23 HP:0001789 Hydrops fetalis 6.610E-6 1.311E-4 8.782E-4 3.014E-3 4 124
24 HP:0012119 Methemoglobinemia 8.117E-6 1.542E-4 1.033E-3 3.701E-3 2 4
25 HP:0000952 Jaundice 9.310E-6 1.698E-4 1.138E-3 4.245E-3 5 330
26 HP:0010885 Aseptic necrosis 1.236E-5 2.167E-4 1.452E-3 5.635E-3 4 145
27 HP:0005264 Abnormality of the gallbladder 1.415E-5 2.389E-4 1.601E-3 6.451E-3 4 150
28 HP:0001396 Cholestasis 1.665E-5 2.711E-4 1.817E-3 7.591E-3 5 371
29 HP:0001901 Polycythemia 3.329E-5 5.235E-4 3.508E-3 1.518E-2 4 186
30 HP:0001005 Dermatological manifestations of systemic disorders 3.743E-5 5.689E-4 3.812E-3 1.707E-2 5 437
31 HP:0004297 Abnormality of the biliary system 5.947E-5 8.383E-4 5.618E-3 2.712E-2 5 480
32 HP:0001555 Asymmetry of the thorax 6.067E-5 8.383E-4 5.618E-3 2.767E-2 2 10
33 HP:0004425 Flat forehead 6.067E-5 8.383E-4 5.618E-3 2.767E-2 2 10
34 HP:0001923 Reticulocytosis 7.815E-5 1.011E-3 6.773E-3 3.564E-2 3 76
35 HP:0001878 Hemolytic anemia 7.980E-5 1.011E-3 6.773E-3 3.639E-2 4 232
36 HP:0011895 Anemia due to reduced life span of red cells 7.980E-5 1.011E-3 6.773E-3 3.639E-2 4 232
37 HP:0000961 Cyanosis 8.449E-5 1.041E-3 6.977E-3 3.853E-2 3 78
38 HP:0100602 Preeclampsia 1.826E-4 2.140E-3 1.434E-2
8.328E-2
 2 17
39 HP:0004312 Abnormality of reticulocytes 1.830E-4 2.140E-3 1.434E-2
8.346E-2
 3 101
40 HP:0001080 Biliary tract abnormality 2.586E-4 2.948E-3 1.975E-2
1.179E-1
 4 313
41 HP:0001297 Stroke 4.707E-4 5.235E-3 3.508E-2
2.146E-1
 4 365
42 HP:0001635 Congestive heart failure 5.503E-4 5.975E-3 4.003E-2
2.509E-1
 4 380
43 HP:0002558 Supernumerary nipple 6.195E-4 6.569E-3 4.402E-2
2.825E-1
 2 31
44 HP:0010808 Protruding tongue 7.026E-4 7.282E-3 4.879E-2
3.204E-1
 2 33
45 HP:0004825 Increased hemoglobin oxygen affinity 8.842E-4 7.862E-3
5.268E-2
4.032E-1
 2 37
46 HP:0009906 Aplasia/Hypoplasia of the earlobes 8.842E-4 7.862E-3
5.268E-2
4.032E-1
 2 37
47 HP:0008346 Increased red cell sickling tendency 8.842E-4 7.862E-3
5.268E-2
4.032E-1
 2 37
48 HP:0100510 Vitamin C deficiency 9.328E-4 7.862E-3
5.268E-2
4.254E-1
 2 38
49 HP:0005505 Refractory anemia 9.328E-4 7.862E-3
5.268E-2
4.254E-1
 2 38
50 HP:0100509 Abnormality of vitamin C metabolism 9.328E-4 7.862E-3
5.268E-2
4.254E-1
 2 38
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 168 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0005097 polychromatophilia 6.426E-7 1.080E-4 6.158E-4 1.080E-4 3 34
2 MP:0003060 increased aerobic running capacity 1.678E-6 1.410E-4 8.040E-4 2.819E-4 2 4
3 MP:0002319 hyperoxia 4.193E-6 2.348E-4 1.339E-3 7.044E-4 2 6
4 MP:0010175 leptocytosis 5.868E-6 2.465E-4 1.406E-3 9.859E-4 2 7
5 MP:0012107 enhanced exercise endurance 1.257E-5 4.107E-4 2.342E-3 2.111E-3 2 10
6 MP:0002640 reticulocytosis 1.467E-5 4.107E-4 2.342E-3 2.464E-3 3 95
7 MP:0005562 decreased mean corpuscular hemoglobin 1.817E-5 4.360E-4 2.487E-3 3.052E-3 3 102
8 MP:0011913 abnormal reticulocyte cell number 2.279E-5 4.491E-4 2.562E-3 3.829E-3 3 110
9 MP:0001577 anemia 2.422E-5 4.491E-4 2.562E-3 4.069E-3 4 376
10 MP:0002424 abnormal reticulocyte morphology 2.673E-5 4.491E-4 2.562E-3 4.491E-3 3 116
11 MP:0002591 decreased mean corpuscular volume 3.591E-5 5.485E-4 3.129E-3 6.033E-3 3 128
12 MP:0000348 abnormal aerobic fitness 5.292E-5 7.408E-4 4.226E-3 8.890E-3 2 20
13 MP:0002874 decreased hemoglobin content 1.464E-4 1.760E-3 1.004E-2 2.459E-2 3 205
14 MP:0008963 increased carbon dioxide production 1.557E-4 1.760E-3 1.004E-2 2.615E-2 2 34
15 MP:0001585 hemolytic anemia 1.747E-4 1.760E-3 1.004E-2 2.936E-2 2 36
16 MP:0010957 abnormal aerobic respiration 1.747E-4 1.760E-3 1.004E-2 2.936E-2 2 36
17 MP:0001589 abnormal mean corpuscular hemoglobin 1.780E-4 1.760E-3 1.004E-2 2.991E-2 3 219
18 MP:0002643 poikilocytosis 2.161E-4 2.017E-3 1.151E-2 3.631E-2 2 40
19 MP:0009409 abnormal skeletal muscle fiber type ratio 2.618E-4 2.315E-3 1.321E-2 4.399E-2 2 44
20 MP:0002642 anisocytosis 2.863E-4 2.405E-3 1.372E-2 4.810E-2 2 46
21 MP:0000226 abnormal mean corpuscular volume 3.130E-4 2.483E-3 1.416E-2
5.259E-2
 3 265
22 MP:0008962 abnormal carbon dioxide production 3.251E-4 2.483E-3 1.416E-2
5.462E-2
 2 49
23 MP:0005563 abnormal hemoglobin content 4.001E-4 2.923E-3 1.667E-2
6.722E-2
 3 288
24 MP:0013663 increased myeloid cell number 4.737E-4 3.316E-3 1.892E-2
7.959E-2
 3 305
25 MP:0002332 abnormal exercise endurance 8.240E-4 5.537E-3 3.158E-2
1.384E-1
 2 78
26 MP:0005505 thrombocytosis 1.048E-3 6.769E-3 3.861E-2
1.760E-1
 2 88
27 MP:0000726 absent lymphocyte 1.544E-3 9.609E-3
5.481E-2
2.595E-1
 2 107
28 MP:0004879 decreased systemic vascular resistance 1.737E-3 1.029E-2
5.867E-2
2.919E-1
 1 3
29 MP:0010067 increased red blood cell distribution width 1.812E-3 1.029E-2
5.867E-2
3.044E-1
 2 116
30 MP:0001588 abnormal hemoglobin 1.837E-3 1.029E-2
5.867E-2
3.086E-1
 3 485
31 MP:0005289 increased oxygen consumption 1.906E-3 1.033E-2
5.892E-2
3.202E-1
 2 119
32 MP:0010954 abnormal cellular respiration 3.129E-3 1.643E-2
9.371E-2
5.257E-1
 2 153
33 MP:0010066 abnormal red blood cell distribution width 3.459E-3 1.761E-2
1.004E-1
5.811E-1
 2 161
34 MP:0004877 abnormal systemic vascular resistance 4.050E-3 2.001E-2
1.142E-1
6.804E-1
 1 7
35 MP:0005288 abnormal oxygen consumption 4.885E-3 2.345E-2
1.337E-1
8.206E-1
 2 192
36 MP:0011951 increased cardiac stroke volume 5.782E-3 2.556E-2
1.458E-1
9.713E-1
 1 10
37 MP:0013026 decreased Ly6C low monocyte number 5.782E-3 2.556E-2
1.458E-1
9.713E-1
 1 10
38 MP:0003394 increased cardiac output 5.782E-3 2.556E-2
1.458E-1
9.713E-1
 1 10
39 MP:0003717 pallor 6.771E-3 2.846E-2
1.624E-1
1.000E0
 2 227
40 MP:0010132 decreased DN2 thymocyte number 6.935E-3 2.846E-2
1.624E-1
1.000E0
 1 12
41 MP:0004200 decreased fetal size 6.947E-3 2.846E-2
1.624E-1
1.000E0
 2 230
42 MP:0004198 abnormal fetal size 7.485E-3 2.994E-2
1.708E-1
1.000E0
 2 239
43 MP:0008574 decreased circulating interferon-alpha level 8.087E-3 3.159E-2
1.802E-1
1.000E0
 1 14
44 MP:0008760 abnormal immunoglobulin heavy chain V(D)J recombination 8.662E-3 3.307E-2
1.887E-1
1.000E0
 1 15
45 MP:0008124 decreased plasmacytoid dendritic cell number 9.237E-3 3.449E-2
1.967E-1
1.000E0
 1 16
46 MP:0006282 abnormal spinal cord dorsal horn morphology 9.812E-3 3.561E-2
2.031E-1
1.000E0
 1 17
47 MP:0005532 abnormal vascular resistance 1.039E-2 3.561E-2
2.031E-1
1.000E0
 1 18
48 MP:0011285 increased circulating erythropoietin level 1.039E-2 3.561E-2
2.031E-1
1.000E0
 1 18
49 MP:0011287 increased erythropoietin level 1.039E-2 3.561E-2
2.031E-1
1.000E0
 1 18
50 MP:0011283 abnormal erythropoietin level 1.096E-2 3.591E-2
2.048E-1
1.000E0
 1 19
Show 45 more annotations

6: Domain [Display Chart] 8 input genes in category / 9 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR000971 Globin InterPro 4.309E-19 1.293E-18 3.657E-18 3.878E-18 6 12
2 PF00042 Globin Pfam 4.309E-19 1.293E-18 3.657E-18 3.878E-18 6 12
3 PS01033 GLOBIN PROSITE 4.309E-19 1.293E-18 3.657E-18 3.878E-18 6 12
4 1.10.490.10 - Gene3D 8.001E-19 1.440E-18 4.074E-18 7.201E-18 6 13
5 IPR012292 Globin/Proto InterPro 8.001E-19 1.440E-18 4.074E-18 7.201E-18 6 13
6 IPR009050 Globin-like InterPro 3.733E-18 5.599E-18 1.584E-17 3.360E-17 6 16
7 IPR002337 Haemoglobin b InterPro 6.819E-14 8.767E-14 2.480E-13 6.137E-13 4 5
8 IPR002339 Haemoglobin pi InterPro 1.596E-7 1.795E-7 5.078E-7 1.436E-6 2 2
9 IPR002338 Haemoglobin a-typ InterPro 9.569E-7 9.569E-7 2.707E-6 8.612E-6 2 4
Show 4 more annotations

7: Pathway [Display Chart] 7 input genes in category / 15 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1270225 Erythrocytes take up oxygen and release carbon dioxide BioSystems: REACTOME 9.130E-9 1.165E-7 3.864E-7 1.369E-7 3 9
2 M19553 Hemoglobin's Chaperone MSigDB C2 BIOCARTA (v6.0) 3.106E-8 1.165E-7 3.864E-7 4.658E-7 3 13
3 1270224 Erythrocytes take up carbon dioxide and release oxygen BioSystems: REACTOME 3.106E-8 1.165E-7 3.864E-7 4.658E-7 3 13
4 1270223 O2/CO2 exchange in erythrocytes BioSystems: REACTOME 3.106E-8 1.165E-7 3.864E-7 4.658E-7 3 13
5 1269898 Scavenging of heme from plasma BioSystems: REACTOME 1.051E-7 3.152E-7 1.046E-6 1.576E-6 3 19
6 194384 African trypanosomiasis BioSystems: KEGG 7.069E-7 1.767E-6 5.864E-6 1.060E-5 3 35
7 1269377 Factors involved in megakaryocyte development and platelet production BioSystems: REACTOME 8.272E-7 1.773E-6 5.882E-6 1.241E-5 4 157
8 152665 Malaria BioSystems: KEGG 1.983E-6 3.305E-6 1.097E-5 2.975E-5 3 49
9 1269897 Binding and Uptake of Ligands by Scavenger Receptors BioSystems: REACTOME 1.983E-6 3.305E-6 1.097E-5 2.975E-5 3 49
10 MAP00970 Aminoacyl tRNA biosynthesis MAP00970 Aminoacyl tRNA biosynthesis GenMAPP 1.008E-2 1.512E-2
5.017E-2
1.512E-1
 1 18
11 MAP00260 Glycine serine and threonine metabolism MAP00260 Glycine serine and threonine metabolism GenMAPP 1.286E-2 1.754E-2
5.820E-2
1.930E-1
 1 23
Show 6 more annotations

8: Pubmed [Display Chart] 9 input genes in category / 2166 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2649166 A review of the molecular genetics of the human alpha-globin gene cluster. Pubmed 1.213E-24 2.626E-21 2.169E-20 2.626E-21 7 12
2 7555018 The multiple functions of hemoglobin. Pubmed 5.457E-22 5.910E-19 4.881E-18 1.182E-18 6 8
3 822353 3' non-coding region sequences in eukaryotic messenger RNA. Pubmed 1.637E-21 1.182E-18 9.761E-18 3.546E-18 6 9
4 17916326 Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA: effects of aminophospholipids and cholesterol. Pubmed 1.861E-19 1.008E-16 8.322E-16 4.031E-16 5 5
5 29866654 Poly(C)-Binding Protein Pcbp2 Enables Differentiation of Definitive Erythropoiesis by Directing Functional Splicing of the Runx1 Transcript. Pubmed 1.117E-18 4.837E-16 3.994E-15 2.418E-15 5 6
6 6985477 The structure and evolution of the human beta-globin gene family. Pubmed 1.042E-17 3.224E-15 2.662E-14 2.257E-14 5 8
7 20439494 Role of the GATA-1/FOG-1/NuRD pathway in the expression of human beta-like globin genes. Pubmed 1.042E-17 3.224E-15 2.662E-14 2.257E-14 5 8
8 881729 Structure of human foetal deoxyhaemoglobin. Pubmed 1.421E-15 3.421E-13 2.825E-12 3.079E-12 4 4
9 23777413 Annotated definition of BCL11A and HMIP-2 haplotypes through the analysis of sicilian β-thalassemia patients with high levels of fetal hemoglobin. Pubmed 1.421E-15 3.421E-13 2.825E-12 3.079E-12 4 4
10 11159543 Expression, purification, and characterization of human hemoglobins Gower-1 (zeta(2)epsilon(2)), Gower-2 (alpha(2)epsilon(2)), and Portland-2 (zeta(2)beta(2)) assembled in complex transgenic-knockout mice. Pubmed 7.106E-15 9.053E-13 7.476E-12 1.539E-11 4 5
11 2444404 A molecular analysis of mouse development from 8 to 10 days post coitum detects changes only in embryonic globin expression. Pubmed 7.106E-15 9.053E-13 7.476E-12 1.539E-11 4 5
12 9887104 Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Pubmed 7.106E-15 9.053E-13 7.476E-12 1.539E-11 4 5
13 873928 Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA. Pubmed 7.106E-15 9.053E-13 7.476E-12 1.539E-11 4 5
14 88735 beta 0 thalassemia, a nonsense mutation in man. Pubmed 7.106E-15 9.053E-13 7.476E-12 1.539E-11 4 5
15 6184621 The deletion in a type of delta 0-beta 0-thalassaemia begins in an inverted AluI repeat. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
16 6194897 Multiple origins of transcription in the 4.5 Kb upstream of the epsilon-globin gene. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
17 2578619 G to A substitution in the distal CCAAT box of the A gamma-globin gene in Greek hereditary persistence of fetal haemoglobin. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
18 3879973 Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
19 3857622 mRNA precursor splicing in vivo: sequence requirements determined by deletion analysis of an intervening sequence. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
20 6292840 mRNA-deficient beta o-thalassemia results from a single nucleotide deletion. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
21 2578620 A point mutation in the A gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
22 7162987 Duplication followed by deletion accounts for the structure of an Indian deletion beta (0)-thalassemia gene. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
23 6701091 Alternative sites of transcription initiation upstream of the canonical cap site in human gamma-globin and beta-globin genes. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
24 6292831 Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
25 7151176 A single-base change at a splice site in a beta 0-thalassemic gene causes abnormal RNA splicing. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
26 6270663 A nucleotide change at a splice junction in the human beta-globin gene is associated with beta 0-thalassemia. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
27 6714226 Molecular characterization of seven beta-thalassemia mutations in Asian Indians. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
28 6165992 beta-Thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta 75 (E19)Leu leads to 0]. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
29 3455755 Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
30 6324786 A fusion gene in man: DNA sequence analysis of the abnormal globin gene of hemoglobin Miyada. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
31 6327288 The beta-globin gene in Sardinian delta beta 0-thalassemia carries a C----T nonsense mutation at codon 39. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
32 6095301 Identification of a retrovirus-like repetitive element in human DNA. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
33 6264391 An intron nucleotide sequence variant in a cloned beta +-thalassaemia globin gene. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
34 6303333 A weak upstream promoter gives rise to long human beta-globin RNA molecules. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
35 2933810 The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
36 6086605 Base substitution at position -88 in a beta-thalassemic globin gene. Further evidence for the role of distal promoter element ACACCC. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
37 6297279 The structure and expression of the haemoglobin genes. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
38 6652684 Unexpected relationships between four large deletions in the human beta-globin gene cluster. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
39 6330670 Human fetal globin DNA sequences suggest novel conversion event. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
40 6210198 A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
41 6895866 Beta + thalassemia: aberrant splicing results from a single point mutation in an intron. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
42 6280057 Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
43 18687678 UCP2 modulates cell proliferation through the MAPK/ERK pathway during erythropoiesis and has no effect on heme biosynthesis. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
44 2581851 Cloning specific complete polyadenylylated 3'-terminal cDNA segments. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
45 6272205 Structure and expression of a cloned beta o thalassaemic globin gene. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
46 6457059 beta zero thalassemia in Sardinia is caused by a nonsense mutation. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
47 3382401 Beta-thalassemia due to a T----A mutation within the ATA box. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
48 3267215 Direct sequencing of enzymatically amplified human genomic DNA. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
49 6985481 Nonsense and frameshift mutations in beta 0-thalassemia detected in cloned beta-globin genes. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
50 6985475 Nonsense mutation as a cause of beta 0 thalassemia. Pubmed 2.132E-14 9.053E-13 7.476E-12 4.617E-11 4 6
Show 45 more annotations

9: Interaction [Display Chart] 9 input genes in category / 153 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ERBB3 ERBB3 interactions 1.873E-8 1.780E-6 9.990E-6 2.865E-6 5 195
2 int:HBB HBB interactions 2.327E-8 1.780E-6 9.990E-6 3.561E-6 4 67
3 int:VCAM1 VCAM1 interactions 1.283E-6 6.546E-5 3.673E-4 1.964E-4 5 456
4 int:HBA2 HBA2 interactions 2.225E-6 8.509E-5 4.774E-4 3.404E-4 3 54
5 int:HBE1 HBE1 interactions 3.443E-6 1.053E-4 5.911E-4 5.267E-4 2 6
6 int:SLC2A14 SLC2A14 interactions 8.256E-6 1.579E-4 8.859E-4 1.263E-3 2 9
7 int:AGA AGA interactions 8.256E-6 1.579E-4 8.859E-4 1.263E-3 2 9
8 int:PGPEP1 PGPEP1 interactions 8.256E-6 1.579E-4 8.859E-4 1.263E-3 2 9
9 int:HBG2 HBG2 interactions 1.261E-5 2.143E-4 1.202E-3 1.929E-3 2 11
10 int:GSTT1 GSTT1 interactions 3.500E-5 5.356E-4 3.005E-3 5.356E-3 2 18
11 int:MSL2 MSL2 interactions 8.011E-5 9.447E-4 5.301E-3 1.226E-2 2 27
12 int:PLXNB1 PLXNB1 interactions 8.011E-5 9.447E-4 5.301E-3 1.226E-2 2 27
13 int:CTSV CTSV interactions 8.625E-5 9.447E-4 5.301E-3 1.320E-2 2 28
14 int:DHRS2 DHRS2 interactions 9.262E-5 9.447E-4 5.301E-3 1.417E-2 2 29
15 int:GDPD1 GDPD1 interactions 9.262E-5 9.447E-4 5.301E-3 1.417E-2 2 29
16 int:HBA1 HBA1 interactions 1.131E-4 1.081E-3 6.066E-3 1.730E-2 2 32
17 int:MACROD1 MACROD1 interactions 1.203E-4 1.083E-3 6.076E-3 1.841E-2 2 33
18 int:NDUFAF5 NDUFAF5 interactions 1.435E-4 1.219E-3 6.842E-3 2.195E-2 2 36
19 int:UCHL5 UCHL5 interactions 1.608E-4 1.290E-3 7.237E-3 2.461E-2 3 225
20 int:HIST1H2BJ HIST1H2BJ interactions 1.686E-4 1.290E-3 7.237E-3 2.579E-2 2 39
21 int:UPF3A UPF3A interactions 1.774E-4 1.293E-3 7.253E-3 2.715E-2 2 40
22 int:ATP6AP1 ATP6AP1 interactions 2.779E-4 1.892E-3 1.062E-2 4.252E-2 2 50
23 int:HSD17B10 HSD17B10 interactions 2.844E-4 1.892E-3 1.062E-2 4.352E-2 3 273
24 int:CTSB CTSB interactions 4.276E-4 2.726E-3 1.530E-2
6.543E-2
 2 62
25 int:CTSD CTSD interactions 4.994E-4 2.938E-3 1.649E-2
7.640E-2
 2 67
26 int:PNKP PNKP interactions 4.994E-4 2.938E-3 1.649E-2
7.640E-2
 2 67
27 int:RFESD RFESD interactions 1.017E-3 5.585E-3 3.133E-2
1.555E-1
 1 2
28 int:INVS INVS interactions 1.022E-3 5.585E-3 3.133E-2
1.564E-1
 2 96
29 int:HBQ1 HBQ1 interactions 1.524E-3 8.043E-3 4.513E-2
2.332E-1
 1 3
30 int:UGT2A3 UGT2A3 interactions 2.032E-3 1.036E-2
5.815E-2
3.109E-1
 1 4
31 int:FBXO32 FBXO32 interactions 2.978E-3 1.457E-2
8.174E-2
4.556E-1
 2 165
32 int:APCDD1 APCDD1 interactions 3.047E-3 1.457E-2
8.174E-2
4.662E-1
 1 6
33 int:GATA5 GATA5 interactions 4.061E-3 1.775E-2
9.960E-2
6.213E-1
 1 8
34 int:AHSP AHSP interactions 4.061E-3 1.775E-2
9.960E-2
6.213E-1
 1 8
35 int:BMP5 BMP5 interactions 4.061E-3 1.775E-2
9.960E-2
6.213E-1
 1 8
36 int:CYTIP CYTIP interactions 4.567E-3 1.889E-2
1.060E-1
6.988E-1
 1 9
37 int:GRID1 GRID1 interactions 4.567E-3 1.889E-2
1.060E-1
6.988E-1
 1 9
38 int:LPAR2 LPAR2 interactions 5.580E-3 2.134E-2
1.197E-1
8.537E-1
 1 11
39 int:MGAT4B MGAT4B interactions 5.580E-3 2.134E-2
1.197E-1
8.537E-1
 1 11
40 int:HBG1 HBG1 interactions 5.580E-3 2.134E-2
1.197E-1
8.537E-1
 1 11
41 int:PNPLA1 PNPLA1 interactions 6.086E-3 2.271E-2
1.274E-1
9.311E-1
 1 12
42 int:CEP250 CEP250 interactions 6.289E-3 2.291E-2
1.285E-1
9.622E-1
 2 242
43 int:SELENOT SELENOT interactions 7.097E-3 2.360E-2
1.324E-1
1.000E0
 1 14
44 int:KLF2 KLF2 interactions 7.097E-3 2.360E-2
1.324E-1
1.000E0
 1 14
45 int:GDAP1 GDAP1 interactions 7.097E-3 2.360E-2
1.324E-1
1.000E0
 1 14
46 int:TMEM92 TMEM92 interactions 7.097E-3 2.360E-2
1.324E-1
1.000E0
 1 14
47 int:DLST DLST interactions 8.054E-3 2.584E-2
1.450E-1
1.000E0
 2 275
48 int:JOSD2 JOSD2 interactions 8.107E-3 2.584E-2
1.450E-1
1.000E0
 1 16
49 int:SPINK7 SPINK7 interactions 8.611E-3 2.689E-2
1.509E-1
1.000E0
 1 17
50 int:SLC4A1 SLC4A1 interactions 9.620E-3 2.857E-2
1.603E-1
1.000E0
 1 19
Show 45 more annotations

10: Cytoband [Display Chart] 9 input genes in category / 4 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 11p15.5 11p15.5 2.135E-8 8.540E-8 1.779E-7 8.540E-8 4 127
2 16p13.3 16p13.3 3.237E-5 6.474E-5 1.349E-4 1.295E-4 3 256
3 2p16.1 2p16.1 8.279E-3 1.104E-2 2.300E-2 3.312E-2 1 32
4 19p13.11 19p13.11 1.982E-2 1.982E-2 4.129E-2
7.928E-2
 1 77

11: Transcription Factor Binding Site [Display Chart] 6 input genes in category / 90 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 9 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 940 Hemoglobin subunits genenames.org 3.302E-23 6.604E-23 9.906E-23 6.604E-23 7 10
2 624 Zinc fingers C2H2-type|Kruppel like factors genenames.org 8.871E-3 8.871E-3 1.331E-2 1.774E-2 1 18

13: Coexpression [Display Chart] 10 input genes in category / 819 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19922785-Table3 Human Leukemia Yang09 42genes GeneSigDB 3.820E-18 3.128E-15 2.279E-14 3.128E-15 7 41
2 17178874-Table1 Human Leukemia Chung06 65genes GeneSigDB 1.994E-14 8.166E-12 5.950E-11 1.633E-11 6 52
3 18811983-Table2 Human Lung Stav08 198genes GeneSigDB 9.472E-12 2.586E-9 1.884E-8 7.758E-9 6 141
4 15090461-Table4 Human StemCell Wagner04 18genes GeneSigDB 4.176E-11 8.550E-9 6.229E-8 3.420E-8 4 17
5 16964388-SuppTable1 Human Ovarian Bachvarov06 155genes GeneSigDB 1.791E-9 2.933E-7 2.137E-6 1.467E-6 5 139
6 15972966-TableS2b Human Colon Lacroix05 61genes GeneSigDB 2.368E-9 3.233E-7 2.355E-6 1.940E-6 4 44
7 M2304 Genes down-regulated in normal 9.5 days post coitus (dpc) embryos compared to normal 8.5 dpc and 9.5 dpc embryos. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.331E-7 1.557E-5 1.134E-4 1.090E-4 3 25
8 17312329-SuppTable2 Human Leukemia Juric07 617genes GeneSigDB 6.260E-7 6.409E-5 4.670E-4 5.127E-4 5 449
9 17989719-SuppTableS2b Human Leukemia Montesinos-Rongen08 54genes GeneSigDB 8.172E-7 7.436E-5 5.418E-4 6.693E-4 3 45
10 17023574-TableS2 Human BoneMarrow Zhan07 458genes GeneSigDB 8.869E-6 7.263E-4 5.292E-3 7.263E-3 4 339
11 19933690-TableS1 Human Endometrial Altmae09 145genes GeneSigDB 1.127E-5 8.391E-4 6.114E-3 9.230E-3 3 107
12 M1788 Genes within amplicon 16p13 identified in a study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.590E-5 1.085E-3 7.906E-3 1.302E-2 3 120
13 17123152-Table3b Human Breast Feng07 21genesUpRegulated GeneSigDB 3.181E-5 2.004E-3 1.460E-2 2.605E-2 2 20
14 14767469-Table3 Human Kidney Bourdeau04 31genes GeneSigDB 5.017E-5 2.935E-3 2.138E-2 4.109E-2 2 25
15 15955831-SuppTable4 Human StemCell Komor05 30genes GeneSigDB 5.434E-5 2.967E-3 2.162E-2 4.451E-2 2 26
16 M7718 Genes up-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 0h versus 1h. MSigDB C7: Immunologic Signatures (v6.0) 7.194E-5 3.437E-3 2.505E-2
5.892E-2
 3 199
17 18487511-TableS2 Human StemCell Singleton08 47genes GeneSigDB 7.267E-5 3.437E-3 2.505E-2
5.951E-2
 2 30
18 17210693-Table2 Human pancreas Fidler07 50genes InVivo GeneSigDB 8.282E-5 3.437E-3 2.505E-2
6.783E-2
 2 32
19 12136251-table5 Human Liver Li02 36genes GeneSigDB 8.282E-5 3.437E-3 2.505E-2
6.783E-2
 2 32
20 17092989-SuppTable1 Human Lymphoma Fogel07 33genes GeneSigDB 8.814E-5 3.437E-3 2.505E-2
7.219E-2
 2 33
21 M11850 Genes up-regulated in WI-38 cells (senescent primary fibroblasts) after inactivation of TP53 [GeneID=7157] by GSE56 polypeptide. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.814E-5 3.437E-3 2.505E-2
7.219E-2
 2 33
22 17297478-Table1 Human Intestine Vecchi07 40genes GeneSigDB 9.363E-5 3.486E-3 2.540E-2
7.668E-2
 2 34
23 M27 Set 'Myc targets1': targets of c-Myc [GeneID=4609] identified by ChIP on chip in cultured cell lines, focusing on E-box-containing genes; high affinity bound subset MSigDB C2: CGP Curated Gene Sets (v6.0) 1.105E-4 3.869E-3 2.819E-2
9.051E-2
 3 230
24 M13273 Genes down-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.134E-4 3.869E-3 2.819E-2
9.286E-2
 3 232
25 15691381-Table4 Human Brain Dilley05 46genes GeneSigDB 1.300E-4 4.259E-3 3.103E-2
1.065E-1
 2 40
26 19567819-SuppTable1 Human Leukemia Gross09 279genes GeneSigDB 1.534E-4 4.600E-3 3.352E-2
1.257E-1
 3 257
27 18172295-SuppTable2 Human Bone Heller08 324genes GeneSigDB 1.643E-4 4.600E-3 3.352E-2
1.345E-1
 3 263
28 17023574-Table2 Human BoneMarrow Zhan07 52genes GeneSigDB 1.648E-4 4.600E-3 3.352E-2
1.350E-1
 2 45
29 18310505-TableS8 Human StemCell Matushansky08 297genes GeneSigDB 1.756E-4 4.600E-3 3.352E-2
1.438E-1
 3 269
30 M1668 Up-regulated in the hypothalamus of aged (22 months) BALB/c mice, compared to young (2 months) controls MSigDB C2: CGP Curated Gene Sets (v6.0) 1.799E-4 4.600E-3 3.352E-2
1.473E-1
 2 47
31 12433680-Table2 Human StemCell Gnatenko03 50genes GeneSigDB 1.799E-4 4.600E-3 3.352E-2
1.473E-1
 2 47
32 14684422-TableS1 Human Leukemia Chiaretti04 314genes GeneSigDB 1.854E-4 4.600E-3 3.352E-2
1.518E-1
 3 274
33 17192395-TableS2c Human StemCell Macaulay07 298genes GeneSigDB 1.854E-4 4.600E-3 3.352E-2
1.518E-1
 3 274
34 M2586 Genes down-regulated in B lymphocytes at 2 h after exprosure to 10 Gy dose of ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.466E-4 5.941E-3 4.329E-2
2.020E-1
 2 55
35 M3335 Genes up-regulated in at least one of three multiple myeloma (MM) cell lines by TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.847E-4 6.661E-3 4.853E-2
2.331E-1
 3 317
36 18716133-TableS1 Human Leukemia Metzeler08 86genes GeneSigDB 3.136E-4 7.134E-3
5.198E-2
2.568E-1
 2 62
37 19351829-SuppTableB Human Lung Daniel09 71genes GeneSigDB 3.662E-4 8.106E-3
5.906E-2
2.999E-1
 2 67
38 16818636-TableS3 Human Leukemia Takeda06 475genes GeneSigDB 3.902E-4 8.411E-3
6.128E-2
3.196E-1
 3 353
39 18172295-SuppTable4 Human Bone Heller08 693genes GeneSigDB 4.133E-4 8.680E-3
6.324E-2
3.385E-1
 3 360
40 15972966-TableS2a Human Colon Lacroix05 114genes GeneSigDB 4.835E-4 9.900E-3
7.213E-2
3.960E-1
 2 77
41 19305503-TableS1 Rat Brain Greco09 425genes GeneSigDB 5.106E-4 1.020E-2
7.431E-2
4.182E-1
 3 387
42 18172295-SuppTable3 Human Bone Heller08 470genes GeneSigDB 5.262E-4 1.026E-2
7.475E-2
4.309E-1
 3 391
43 18487511-TableS1 Human StemCell Singleton08 114genes GeneSigDB 6.310E-4 1.202E-2
8.756E-2
5.168E-1
 2 88
44 15735049-Table2 Human Thyroid Jarzab05 102genes GeneSigDB 7.659E-4 1.394E-2
1.016E-1
6.272E-1
 2 97
45 16863911-table1 Human StemCell Fruehauf06 110genes GeneSigDB 7.659E-4 1.394E-2
1.016E-1
6.272E-1
 2 97
46 15297395-SuppTable1 Human Lymphoma Sriuranpong04 670genes Epithelium(N)Metaplastic/DisplasticLesions(R)Carcinoma(T) GeneSigDB 8.232E-4 1.446E-2
1.054E-1
6.742E-1
 3 456
47 19893615-Table5 Human Thyroid Fontaine09 103genes GeneSigDB 8.299E-4 1.446E-2
1.054E-1
6.797E-1
 2 101
48 M14127 Genes up-regulated in multiple myeloma (MM) cell lines treated with both decitabine [PubChem=451668] TSA [PubChem=5562]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.497E-4 1.450E-2
1.056E-1
6.959E-1
 3 461
49 M3185 Genes down-regulated in at least one of three multiple myeloma (MM) cell lines treated with the DNA hypomethylating agent decitabine (5-aza-2'-deoxycytidine) [PubChem=451668]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.964E-4 1.498E-2
1.092E-1
7.342E-1
 2 105
50 14522937-Table1 Human Kidney Twine03 132genes GeneSigDB 1.149E-3 1.882E-2
1.371E-1
9.410E-1
 2 119
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 10 input genes in category / 1685 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/mid-fetal Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/mid-fetal Fetal, Development 2.817E-15 4.746E-12 3.800E-11 4.746E-12 5 11
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Tumour Wilms F-U/Kidney Tumour Wilms F22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney F-U/Kidney Tumour Wilms F-U/Kidney Tumour Wilms F22 Adult, Development, and Cancer types 1.220E-14 1.028E-11 8.229E-11 2.056E-11 5 14
3 PP epoMEP 500 K4 PP epoMEP top-relative-expression-ranked 500 k-means-cluster#4 PCBC 1.942E-14 1.091E-11 8.735E-11 3.273E-11 6 49
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour Wilms NK cell/Kidney Tumour Wilms NK22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour Wilms NK cell/Kidney Tumour Wilms NK22 Adult, Development, and Cancer types 7.079E-14 2.386E-11 1.910E-10 1.193E-10 5 19
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Erythroblast/Kidney Tumour Wilms Erythroblast Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Erythroblast/Kidney Tumour Wilms Erythroblast Adult, Development, and Cancer types 7.079E-14 2.386E-11 1.910E-10 1.193E-10 5 19
6 PP MEP 500 K1 PP MEP top-relative-expression-ranked 500 k-means-cluster#1 PCBC 6.041E-13 1.696E-10 1.358E-9 1.018E-9 6 85
7 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Erythrocyte contaminated (ER.C) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Erythrocyte contaminated (ER.C) Fetal, Development 7.766E-13 1.869E-10 1.497E-9 1.309E-9 4 7
8 PP MEP 100 PP MEP top-relative-expression-ranked 100 PCBC 1.643E-12 3.075E-10 2.462E-9 2.768E-9 6 100
9 PP RBC 100 PP RBC top-relative-expression-ranked 100 PCBC 1.643E-12 3.075E-10 2.462E-9 2.768E-9 6 100
10 PP epoMEP 1000 K2 PP epoMEP top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 2.786E-12 4.695E-10 3.759E-9 4.695E-9 6 109
11 PP MEP 1000 K1 PP MEP top-relative-expression-ranked 1000 k-means-cluster#1 PCBC 3.004E-11 4.245E-9 3.399E-8 5.062E-8 6 161
12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour Wilms PT-U/Kidney Tumour Wilms PT22 Adult, Development, and Cancer types 3.023E-11 4.245E-9 3.399E-8 5.094E-8 4 15
13 PP MEG 2500 K1 PP MEG top-relative-expression-ranked 2500 k-means-cluster#1 PCBC 5.522E-11 7.157E-9 5.731E-8 9.304E-8 6 178
14 Extraglomerular mesangium (EM)/Extraglomerular mesangium (EM) e Extraglomerular mesangium (EM)/Extraglomerular mesangium (EM) e 6.110E-11 7.291E-9 5.838E-8 1.030E-7 6 181
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Tumour Wilms U U/Kidney Tumour Wilms U22 Adult, Development, and Cancer types 6.773E-11 7.291E-9 5.838E-8 1.141E-7 4 18
16 gudmap dev gonad e13.5 F gudmap devVascOvary Flk k3 100 dev gonad e13.5 F DevVascOvary Flk k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 6.923E-11 7.291E-9 5.838E-8 1.167E-7 3 3
17 Erythrocyte (ER) Erythrocyte (ER) 8.732E-11 8.655E-9 6.930E-8 1.471E-7 6 192
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour Wilms IF-U/Kidney Tumour Wilms IF22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Tumour Wilms IF-U/Kidney Tumour Wilms IF22 Adult, Development, and Cancer types 1.072E-10 1.003E-8 8.035E-8 1.806E-7 4 20
19 PP MEG 1000 K5 PP MEG top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.541E-10 1.367E-8 1.095E-7 2.597E-7 5 81
20 PP RBC 500 K2 PP RBC top-relative-expression-ranked 500 k-means-cluster#2 PCBC 1.779E-10 1.499E-8 1.200E-7 2.998E-7 6 216
21 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Endothelial cells (ED)/early fetal/ED c Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Endothelial cells (ED)/early fetal/ED c Fetal, Development 2.349E-10 1.799E-8 1.441E-7 3.958E-7 4 24
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Tumour Wilms T U/Kidney Tumour Wilms T22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T U/Kidney Tumour Wilms T U/Kidney Tumour Wilms T22 Adult, Development, and Cancer types 2.349E-10 1.799E-8 1.441E-7 3.958E-7 4 24
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour Wilms R U/Kidney Tumour Wilms R22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour Wilms R U/Kidney Tumour Wilms R22 Adult, Development, and Cancer types 2.796E-10 2.048E-8 1.640E-7 4.711E-7 4 25
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal-Medulla Wilms R U/Kidney Normal-Medulla Wilms R4 Adult, Development, and Cancer types 3.294E-10 2.168E-8 1.736E-7 5.550E-7 5 94
25 PP MEP 500 PP MEP top-relative-expression-ranked 500 PCBC 3.298E-10 2.168E-8 1.736E-7 5.557E-7 7 494
26 PP RBC 500 PP RBC top-relative-expression-ranked 500 PCBC 3.345E-10 2.168E-8 1.736E-7 5.636E-7 7 495
27 PP epoMEP 500 PP epoMEP top-relative-expression-ranked 500 PCBC 3.538E-10 2.208E-8 1.768E-7 5.962E-7 7 499
28 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Overall Top 200 Genes 2.571E-9 1.547E-7 1.239E-6 4.332E-6 5 141
29 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Erythrocyte (ER) Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Erythrocyte (ER) Fetal, Development 3.172E-9 1.843E-7 1.476E-6 5.345E-6 5 147
30 gudmap dev gonad e12.5 M gudmap devVasTestis Flk k3 100 dev gonad e12.5 M DevVasTestis Flk k-means-cluster#3 top-relative-expression-ranked 100 Gudmap Mouse ST 1.0 3.872E-9 2.048E-7 1.640E-6 6.525E-6 3 8
31 geo heart 500 K5 geo heart top-relative-expression-ranked 500 k-means-cluster#5 PCBC 3.872E-9 2.048E-7 1.640E-6 6.525E-6 3 8
32 Kidney10XCellRanger Six2TGC E14 Eryth Eryth Overall Top 200 Genes Kidney10XCellRanger Six2TGC E14 Eryth Eryth Overall Top 200 Genes 4.010E-9 2.048E-7 1.640E-6 6.757E-6 5 154
33 Kidney10XCellRanger Six2TGC E14 Eryth Eryth Top 200 Kidney10XCellRanger Six2TGC E14 Eryth Eryth Top 200 4.010E-9 2.048E-7 1.640E-6 6.757E-6 5 154
34 ratio EB-blastocyst vs EB-cbCD34 500 K2 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 k-means-cluster#2 PCBC 4.658E-9 2.308E-7 1.848E-6 7.849E-6 4 49
35 Kidney10XCellRanger Six2KI E14 Eryth Eryth Subtype E14-Six2KI-Eryth-C11-KC7 Top 200 Genes Kidney10XCellRanger Six2KI E14 Eryth Eryth Subtype E14-Six2KI-Eryth-C11-KC7 Top 200 Genes 5.175E-9 2.491E-7 1.995E-6 8.720E-6 5 162
36 PP epoMEP 2500 K4 PP epoMEP top-relative-expression-ranked 2500 k-means-cluster#4 PCBC 5.553E-9 2.599E-7 2.081E-6 9.356E-6 6 383
37 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Extraglomerular mesangium (EM)/early fetal/EM e Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Extraglomerular mesangium (EM)/early fetal/EM e Fetal, Development 6.945E-9 3.163E-7 2.532E-6 1.170E-5 4 54
38 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C7-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C7-KC1 Top 200 Genes 7.201E-9 3.193E-7 2.557E-6 1.213E-5 5 173
39 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC Unk Subtype UnkH Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 9.309E-9 4.022E-7 3.220E-6 1.569E-5 4 58
40 PP RBC 1000 K4 PP RBC top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 1.034E-8 4.355E-7 3.487E-6 1.742E-5 6 425
41 Cap mesenchyme (CM)/Cap mesenchyme (CM) a Cap mesenchyme (CM)/Cap mesenchyme (CM) a 1.123E-8 4.614E-7 3.695E-6 1.892E-5 5 189
42 Facebase RNAseq e9.5 Maxillary Arch 500 K1 FacebaseRNAseq e9.5 Maxillary Arch top-relative-expression-ranked 500 k-means-cluster#1 FaceBase_RNAseq 1.305E-8 5.146E-7 4.121E-6 2.200E-5 4 63
43 Endothelial cells (ED)/Endothelial cells (ED) c Endothelial cells (ED)/Endothelial cells (ED) c 1.313E-8 5.146E-7 4.121E-6 2.213E-5 5 195
44 PP HSC 2500 K1 PP HSC top-relative-expression-ranked 2500 k-means-cluster#1 PCBC 1.397E-8 5.350E-7 4.284E-6 2.354E-5 6 447
45 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C6-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C6-KC1 Top 200 Genes 1.950E-8 7.301E-7 5.846E-6 3.285E-5 5 211
46 Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C1-KC1 Top 200 Genes Kidney10XCellRanger Six2TGC TSC1 E14 Eryth Eryth Subtype E14-Six2TGC Tsc1-Eryth-C1-KC1 Top 200 Genes 2.403E-8 8.803E-7 7.048E-6 4.049E-5 5 220
47 Facebase RNAseq e10.5 Olfactory Pit 1000 K3 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 1000 k-means-cluster#3 FaceBase_RNAseq 2.516E-8 9.019E-7 7.222E-6 4.239E-5 4 74
48 PP MEP 2500 K2 PP MEP top-relative-expression-ranked 2500 k-means-cluster#2 PCBC 2.627E-8 9.222E-7 7.384E-6 4.427E-5 6 497
49 Kidney10XCellRanger Six2KI E14 Eryth Eryth Top 200 Kidney10XCellRanger Six2KI E14 Eryth Eryth Top 200 2.937E-8 1.010E-6 8.086E-6 4.948E-5 5 229
50 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IN-U/Kidney Tumour Wilms IN-U/Kidney Tumour Wilms IN22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IN-U/Kidney Tumour Wilms IN-U/Kidney Tumour Wilms IN22 Adult, Development, and Cancer types 3.865E-8 1.302E-6 1.043E-5 6.512E-5 3 16
Show 45 more annotations

15: Computational [Display Chart] 8 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 10 input genes in category / 213 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-92a-1-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.016E-5 1.494E-2
8.878E-2
 1.494E-2 2 91
2 GTGCAAT,MIR-32:MSigDB GTGCAAT,MIR-32:MSigDB MSigDB 7.026E-4 2.494E-2
1.482E-1
1.497E-1
 2 289
3 GTGCAAT,MIR-367:MSigDB GTGCAAT,MIR-367:MSigDB MSigDB 7.026E-4 2.494E-2
1.482E-1
1.497E-1
 2 289
4 GTGCAAT,MIR-92:MSigDB GTGCAAT,MIR-92:MSigDB MSigDB 7.026E-4 2.494E-2
1.482E-1
1.497E-1
 2 289
5 GTGCAAT,MIR-363:MSigDB GTGCAAT,MIR-363:MSigDB MSigDB 7.026E-4 2.494E-2
1.482E-1
1.497E-1
 2 289
6 GTGCAAT,MIR-25:MSigDB GTGCAAT,MIR-25:MSigDB MSigDB 7.026E-4 2.494E-2
1.482E-1
1.497E-1
 2 289
Show 1 more annotation

17: Drug [Display Chart] 9 input genes in category / 2158 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011979741 syntometrine Stitch 1.847E-23 1.329E-20 1.097E-19 3.986E-20 7 11
2 CID006451852 NFPLP Stitch 1.847E-23 1.329E-20 1.097E-19 3.986E-20 7 11
3 CID000130204 N-(2-hydroxypropyl)valine Stitch 1.847E-23 1.329E-20 1.097E-19 3.986E-20 7 11
4 CID000128182 2-hydroxylamino-5-ethyl-5-propylbarbituric acid Stitch 4.433E-23 1.594E-20 1.316E-19 9.566E-20 7 12
5 CID000171553 Ferastral Stitch 4.433E-23 1.594E-20 1.316E-19 9.566E-20 7 12
6 CID000440190 7-methylguanosine 5'-phosphate Stitch 4.433E-23 1.594E-20 1.316E-19 9.566E-20 7 12
7 CID000016717 3-aminobiphenyl Stitch 9.604E-23 2.591E-20 2.138E-19 2.073E-19 7 13
8 CID000123452 pentafluorophenyl isothiocyanate Stitch 9.604E-23 2.591E-20 2.138E-19 2.073E-19 7 13
9 CID000076082 6-amino-m-cresol Stitch 1.921E-22 4.605E-20 3.801E-19 4.145E-19 7 14
10 CID000013543 NMAM Stitch 3.601E-22 6.476E-20 5.345E-19 7.771E-19 7 15
11 CID000072162 BW12C Stitch 3.601E-22 6.476E-20 5.345E-19 7.771E-19 7 15
12 CID000170449 methyl acetyl phosphate Stitch 3.601E-22 6.476E-20 5.345E-19 7.771E-19 7 15
13 CID000373677 colupulone Stitch 6.401E-22 9.209E-20 7.601E-19 1.381E-18 7 16
14 CID000123930 AC1L3XKM Stitch 6.401E-22 9.209E-20 7.601E-19 1.381E-18 7 16
15 CID000173813 Gm(5')ppp Stitch 6.401E-22 9.209E-20 7.601E-19 1.381E-18 7 16
16 CID000107912 N-(2-hydroxyethyl)valine Stitch 1.088E-21 1.381E-19 1.140E-18 2.348E-18 7 17
17 CID000131347 Rsr 4 Stitch 1.088E-21 1.381E-19 1.140E-18 2.348E-18 7 17
18 CID000001351 AC1L1BA8 Stitch 1.780E-21 2.022E-19 1.669E-18 3.842E-18 7 18
19 CID000122173 neokyotorphin Stitch 1.780E-21 2.022E-19 1.669E-18 3.842E-18 7 18
20 CID000132952 Hemorphin 7 Stitch 2.819E-21 3.041E-19 2.511E-18 6.083E-18 7 19
21 CID000107819 C19565 Stitch 4.336E-21 4.253E-19 3.511E-18 9.357E-18 7 20
22 CID000122288 glucitollysine Stitch 4.336E-21 4.253E-19 3.511E-18 9.357E-18 7 20
23 CID000119462 S-phenylcysteine Stitch 6.504E-21 5.848E-19 4.827E-18 1.404E-17 7 21
24 CID000024861 iron phosphate Stitch 6.504E-21 5.848E-19 4.827E-18 1.404E-17 7 21
25 CID000449473 3-iodo-4-hydroxybenzoic acid Stitch 9.538E-21 7.351E-19 6.068E-18 2.058E-17 7 22
26 CID000070549 Cilag Stitch 9.538E-21 7.351E-19 6.068E-18 2.058E-17 7 22
27 CID000442690 tellimagrandin I Stitch 9.538E-21 7.351E-19 6.068E-18 2.058E-17 7 22
28 CID000072284 NSC69862 Stitch 9.538E-21 7.351E-19 6.068E-18 2.058E-17 7 22
29 CID000110993 L-histidine beta-naphthylamide Stitch 1.371E-20 9.246E-19 7.632E-18 2.959E-17 7 23
30 CID000076008 n-butyl isocyanide Stitch 1.371E-20 9.246E-19 7.632E-18 2.959E-17 7 23
31 CID000407619 NSC-7813 Stitch 1.371E-20 9.246E-19 7.632E-18 2.959E-17 7 23
32 CID000425294 AC1L8FE9 Stitch 1.371E-20 9.246E-19 7.632E-18 2.959E-17 7 23
33 CID000024877 ferric pyrophosphate Stitch 1.935E-20 1.266E-18 1.045E-17 4.177E-17 7 24
34 CID005748247 Chlorocruorin Stitch 2.688E-20 1.657E-18 1.368E-17 5.800E-17 7 25
35 CID000126533 Vv-hemorphin-7 Stitch 2.688E-20 1.657E-18 1.368E-17 5.800E-17 7 25
36 CID001274030 thiohydantoin Stitch 3.678E-20 2.089E-18 1.724E-17 7.937E-17 7 26
37 CID005464045 DNME Stitch 3.678E-20 2.089E-18 1.724E-17 7.937E-17 7 26
38 CID000071372 iron (II) d-gluconate dihydrate Stitch 3.678E-20 2.089E-18 1.724E-17 7.937E-17 7 26
39 CID000010679 2,7-diaminofluorene Stitch 4.965E-20 2.747E-18 2.268E-17 1.071E-16 7 27
40 CID000016533 betamethasone valerate Stitch 6.619E-20 3.484E-18 2.876E-17 1.428E-16 7 28
41 CID000026818 urobilinogen Stitch 6.619E-20 3.484E-18 2.876E-17 1.428E-16 7 28
42 CID000126532 Lvv-hemorphin-7 Stitch 8.724E-20 4.483E-18 3.700E-17 1.883E-16 7 29
43 CID000100101 NSC334284 Stitch 1.138E-19 5.581E-18 4.607E-17 2.456E-16 7 30
44 CID000025738 dimethyl adipimidate Stitch 1.138E-19 5.581E-18 4.607E-17 2.456E-16 7 30
45 CID000008247 acetylphenylhydrazine Stitch 1.470E-19 6.748E-18 5.570E-17 3.171E-16 7 31
46 CID005464467 trimidox Stitch 1.470E-19 6.748E-18 5.570E-17 3.171E-16 7 31
47 CID000462147 AC1LA5IX Stitch 1.470E-19 6.748E-18 5.570E-17 3.171E-16 7 31
48 CID000065042 diaspirin Stitch 3.006E-19 1.351E-17 1.116E-16 6.487E-16 7 34
49 CID000005853 metrifonate Stitch 5.751E-19 2.533E-17 2.091E-16 1.241E-15 7 37
50 CID000007518 phenylhydroxylamine Stitch 7.050E-19 3.043E-17 2.511E-16 1.521E-15 7 38
Show 45 more annotations

18: Disease [Display Chart] 10 input genes in category / 309 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0878521 Beta thalassemia trait DisGeNET BeFree 3.230E-16 4.279E-14 2.701E-13 9.980E-14 6 20
2 C3841475 beta^+^ Thalassemia DisGeNET BeFree 3.396E-16 4.279E-14 2.701E-13 1.049E-13 8 121
3 C0005283 beta Thalassemia DisGeNET Curated 4.154E-16 4.279E-14 2.701E-13 1.284E-13 8 124
4 C1456873 alpha^+^ Thalassemia DisGeNET BeFree 2.204E-15 1.703E-13 1.075E-12 6.811E-13 7 69
5 C0271985 Delta-Beta Thalassemia DisGeNET Curated 2.141E-14 1.323E-12 8.351E-12 6.615E-12 5 12
6 C0019025 Hemoglobin F Disease DisGeNET Curated 3.478E-14 1.791E-12 1.131E-11 1.075E-11 5 13
7 C0019045 Hemoglobinopathies DisGeNET Curated 7.762E-14 3.426E-12 2.163E-11 2.398E-11 6 46
8 C0472767 Beta thalassemia intermedia DisGeNET Curated 3.137E-13 1.129E-11 7.128E-11 9.694E-11 5 19
9 C0271990 delta-Thalassemia DisGeNET BeFree 3.655E-13 1.129E-11 7.128E-11 1.129E-10 4 5
10 C4274391 Dominant beta-thalassemia DisGeNET BeFree 3.655E-13 1.129E-11 7.128E-11 1.129E-10 4 5
11 C0002312 alpha-Thalassemia DisGeNET Curated 1.081E-12 3.037E-11 1.917E-10 3.340E-10 6 70
12 C0039730 Thalassemia DisGeNET BeFree 1.526E-12 3.929E-11 2.480E-10 4.715E-10 6 74
13 C0271979 Thalassemia Intermedia DisGeNET BeFree 1.772E-12 4.211E-11 2.658E-10 5.474E-10 5 26
14 C0271980 beta^0^ Thalassemia DisGeNET BeFree 2.174E-12 4.797E-11 3.028E-10 6.716E-10 5 27
15 C0002895 Anemia, Sickle Cell DisGeNET Curated 6.235E-12 1.284E-10 8.107E-10 1.927E-9 7 209
16 C0349705 Abnormal hemoglobin finding DisGeNET Curated 9.199E-12 1.672E-10 1.055E-9 2.842E-9 4 9
17 C2873756 Severe beta thalassemia DisGeNET BeFree 9.199E-12 1.672E-10 1.055E-9 2.842E-9 4 9
18 C0030232 Pallor DisGeNET Curated 2.010E-11 3.451E-10 2.178E-9 6.212E-9 5 41
19 C3161174 Hemoglobin H Disease DisGeNET Curated 5.214E-11 8.479E-10 5.352E-9 1.611E-8 4 13
20 C0271994 Hereditary persistence of fetal hemoglobin thalassemia DisGeNET BeFree 9.947E-11 1.537E-9 9.701E-9 3.074E-8 4 15
21 cv:C0002312 alpha Thalassemia Clinical Variations 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
22 cv:C1841621 Fetal hemoglobin quantitative trait locus 1 Clinical Variations 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
23 C0238159 Hemoglobin E disease DisGeNET Curated 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
24 cv:C0700299 Heinz body anemias Clinical Variations 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
25 C3539063 Bart's Hemoglobinopathy DisGeNET BeFree 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
26 C0700299 Heinz Body Anemias DisGeNET Curated 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
27 C3161373 Dominant thalassemia DisGeNET BeFree 1.692E-10 1.937E-9 1.222E-8 5.229E-8 3 3
28 C0002875 Cooley's anemia DisGeNET Curated 2.033E-10 2.244E-9 1.416E-8 6.283E-8 5 64
29 C0472777 Hemoglobin E/beta thalassemia disease DisGeNET Curated 6.767E-10 6.150E-9 3.882E-8 2.091E-7 3 4
30 C0271987 ^A^gamma delta beta^0^ thalassemia DisGeNET BeFree 6.767E-10 6.150E-9 3.882E-8 2.091E-7 3 4
31 OMIN:604131 THALASSEMIAS OMIM 6.767E-10 6.150E-9 3.882E-8 2.091E-7 3 4
32 OMIN:141749 FETAL HEMOGLOBIN QUANTITATIVE TRAIT LOCUS 1; HBFQTL1 OMIM 6.767E-10 6.150E-9 3.882E-8 2.091E-7 3 4
33 C4025630 Abnormal bone structure DisGeNET Curated 6.767E-10 6.150E-9 3.882E-8 2.091E-7 3 4
34 C4023136 Reduced alpha/beta synthesis ratio DisGeNET Curated 6.767E-10 6.150E-9 3.882E-8 2.091E-7 3 4
35 C0023440 Acute Erythroblastic Leukemia DisGeNET Curated 1.174E-9 1.036E-8 6.542E-8 3.627E-7 6 220
36 C0878520 beta Thalassemia, heterozygous DisGeNET BeFree 1.691E-9 1.452E-8 9.163E-8 5.226E-7 3 5
37 C0085576 Iron-Refractory Iron Deficiency Anemia DisGeNET Curated 1.988E-9 1.660E-8 1.048E-7 6.144E-7 4 30
38 C3665425 Hemoglobin M Disease DisGeNET Curated 3.381E-9 2.749E-8 1.736E-7 1.045E-6 3 6
39 C0085077 Sweet Syndrome DisGeNET BeFree 5.343E-9 4.233E-8 2.672E-7 1.651E-6 4 38
40 C0271986 delta beta^0^ Thalassemia DisGeNET BeFree 5.915E-9 4.458E-8 2.814E-7 1.828E-6 3 7
41 C0239941 Foetal haemoglobin increased DisGeNET Curated 5.915E-9 4.458E-8 2.814E-7 1.828E-6 3 7
42 C0162119 Hemoglobin low DisGeNET Curated 6.671E-9 4.908E-8 3.098E-7 2.061E-6 5 127
43 C0238644 Anemia, severe DisGeNET BeFree 7.323E-9 5.263E-8 3.322E-7 2.263E-6 4 41
44 C0263454 Chloracne DisGeNET Curated 8.919E-9 6.264E-8 3.954E-7 2.756E-6 4 43
45 C0086981 Sicca Syndrome DisGeNET BeFree 1.404E-8 9.642E-8 6.086E-7 4.339E-6 4 48
46 C0702157 Thalassemia trait DisGeNET BeFree 2.026E-8 1.361E-7 8.591E-7 6.261E-6 3 10
47 C0038002 Splenomegaly DisGeNET Curated 4.920E-8 3.234E-7 2.042E-6 1.520E-5 5 189
48 C4025735 Nonspherocytic hemolytic anemia DisGeNET Curated 6.138E-8 3.951E-7 2.494E-6 1.897E-5 3 14
49 C0018790 Cardiac Arrest DisGeNET Curated 6.367E-8 4.015E-7 2.534E-6 1.967E-5 5 199
50 C0002871 Anemia DisGeNET Curated 7.219E-8 4.461E-7 2.816E-6 2.231E-5 6 438
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