Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc168_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 19 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030695 GTPase regulator activity 1.438E-10 1.789E-9 6.347E-9 2.731E-9 6 312
2 GO:0060589 nucleoside-triphosphatase regulator activity 2.590E-10 1.789E-9 6.347E-9 4.922E-9 6 344
3 GO:0001965 G-protein alpha-subunit binding 2.825E-10 1.789E-9 6.347E-9 5.367E-9 4 33
4 GO:0005096 GTPase activator activity 1.586E-8 7.536E-8 2.673E-7 3.014E-7 5 283
5 GO:0005092 GDP-dissociation inhibitor activity 9.390E-6 3.568E-5 1.266E-4 1.784E-4 2 13
6 GO:0031755 Edg-2 lysophosphatidic acid receptor binding 7.501E-4 2.036E-3 7.223E-3 1.425E-2 1 2
7 GO:0031753 endothelial differentiation G protein-coupled receptor binding 7.501E-4 2.036E-3 7.223E-3 1.425E-2 1 2
8 GO:0047696 beta-adrenergic receptor kinase activity 1.500E-3 3.562E-3 1.264E-2 2.849E-2 1 4
9 GO:0031694 alpha-2A adrenergic receptor binding 1.874E-3 3.957E-3 1.404E-2 3.561E-2 1 5
10 GO:0004703 G protein-coupled receptor kinase activity 2.623E-3 4.984E-3 1.768E-2 4.984E-2 1 7
11 GO:0032794 GTPase activating protein binding 6.734E-3 1.163E-2 4.126E-2
1.279E-1
 1 18
12 GO:0031690 adrenergic receptor binding 7.479E-3 1.184E-2 4.201E-2
1.421E-1
 1 20
13 GO:0030159 receptor signaling complex scaffold activity 9.714E-3 1.420E-2
5.037E-2
1.846E-1
 1 26
14 GO:0032947 protein-containing complex scaffold activity 2.890E-2 3.922E-2
1.391E-1
5.491E-1
 1 78
Show 9 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 141 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008277 regulation of G protein-coupled receptor signaling pathway 4.155E-10 5.859E-8 3.240E-7 5.859E-8 5 137
2 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 5.236E-7 3.691E-5 2.041E-4 7.382E-5 3 47
3 GO:0038032 termination of G protein-coupled receptor signaling pathway 3.759E-4 1.064E-2
5.885E-2
5.300E-2
 1 1
4 GO:0003108 negative regulation of the force of heart contraction by chemical signal 3.759E-4 1.064E-2
5.885E-2
5.300E-2
 1 1
5 GO:0043407 negative regulation of MAP kinase activity 3.774E-4 1.064E-2
5.885E-2
5.321E-2
 2 80
6 GO:0010070 zygote asymmetric cell division 7.516E-4 1.766E-2
9.767E-2
1.060E-1
 1 2
7 GO:0071901 negative regulation of protein serine/threonine kinase activity 1.085E-3 1.892E-2
1.046E-1
1.530E-1
 2 136
8 GO:0051661 maintenance of centrosome location 1.127E-3 1.892E-2
1.046E-1
1.589E-1
 1 3
9 GO:0007051 spindle organization 1.283E-3 1.892E-2
1.046E-1
1.810E-1
 2 148
10 GO:0031914 negative regulation of synaptic plasticity 1.503E-3 1.892E-2
1.046E-1
2.119E-1
 1 4
11 GO:0023021 termination of signal transduction 1.503E-3 1.892E-2
1.046E-1
2.119E-1
 1 4
12 GO:0043409 negative regulation of MAPK cascade 1.611E-3 1.892E-2
1.046E-1
2.271E-1
 2 166
13 GO:0042699 follicle-stimulating hormone signaling pathway 2.629E-3 2.647E-2
1.464E-1
3.706E-1
 1 7
14 GO:0045988 negative regulation of striated muscle contraction 3.004E-3 2.647E-2
1.464E-1
4.235E-1
 1 8
15 GO:0003057 regulation of the force of heart contraction by chemical signal 3.004E-3 2.647E-2
1.464E-1
4.235E-1
 1 8
16 GO:0007217 tachykinin receptor signaling pathway 3.004E-3 2.647E-2
1.464E-1
4.235E-1
 1 8
17 GO:0051657 maintenance of organelle location 3.379E-3 2.802E-2
1.549E-1
4.764E-1
 1 9
18 GO:0006469 negative regulation of protein kinase activity 3.577E-3 2.802E-2
1.549E-1
5.044E-1
 2 249
19 GO:0033673 negative regulation of kinase activity 4.345E-3 3.224E-2
1.783E-1
6.126E-1
 2 275
20 GO:0007213 G protein-coupled acetylcholine receptor signaling pathway 6.747E-3 3.749E-2
2.073E-1
9.514E-1
 1 18
21 GO:1905145 cellular response to acetylcholine 6.747E-3 3.749E-2
2.073E-1
9.514E-1
 1 18
22 GO:1903831 signal transduction involved in cellular response to ammonium ion 6.747E-3 3.749E-2
2.073E-1
9.514E-1
 1 18
23 GO:1905144 response to acetylcholine 6.747E-3 3.749E-2
2.073E-1
9.514E-1
 1 18
24 GO:0098926 postsynaptic signal transduction 6.747E-3 3.749E-2
2.073E-1
9.514E-1
 1 18
25 GO:0095500 acetylcholine receptor signaling pathway 6.747E-3 3.749E-2
2.073E-1
9.514E-1
 1 18
26 GO:0043405 regulation of MAP kinase activity 7.181E-3 3.749E-2
2.073E-1
1.000E0
 2 356
27 GO:0033605 positive regulation of catecholamine secretion 7.495E-3 3.749E-2
2.073E-1
1.000E0
 1 20
28 GO:0008356 asymmetric cell division 7.495E-3 3.749E-2
2.073E-1
1.000E0
 1 20
29 GO:0051642 centrosome localization 7.868E-3 3.749E-2
2.073E-1
1.000E0
 1 21
30 GO:0051348 negative regulation of transferase activity 8.066E-3 3.749E-2
2.073E-1
1.000E0
 2 378
31 GO:0000132 establishment of mitotic spindle orientation 8.241E-3 3.749E-2
2.073E-1
1.000E0
 1 22
32 GO:0022401 negative adaptation of signaling pathway 8.988E-3 3.807E-2
2.105E-1
1.000E0
 1 24
33 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 8.988E-3 3.807E-2
2.105E-1
1.000E0
 1 24
34 GO:0045822 negative regulation of heart contraction 9.734E-3 3.807E-2
2.105E-1
1.000E0
 1 26
35 GO:0023058 adaptation of signaling pathway 9.734E-3 3.807E-2
2.105E-1
1.000E0
 1 26
36 GO:0040001 establishment of mitotic spindle localization 9.734E-3 3.807E-2
2.105E-1
1.000E0
 1 26
37 GO:0001933 negative regulation of protein phosphorylation 1.016E-2 3.807E-2
2.105E-1
1.000E0
 2 426
38 GO:0051294 establishment of spindle orientation 1.048E-2 3.807E-2
2.105E-1
1.000E0
 1 28
39 GO:0006979 response to oxidative stress 1.076E-2 3.807E-2
2.105E-1
1.000E0
 2 439
40 GO:0000188 inactivation of MAPK activity 1.085E-2 3.807E-2
2.105E-1
1.000E0
 1 29
41 GO:0045932 negative regulation of muscle contraction 1.122E-2 3.807E-2
2.105E-1
1.000E0
 1 30
42 GO:0007616 long-term memory 1.197E-2 3.807E-2
2.105E-1
1.000E0
 1 32
43 GO:0000226 microtubule cytoskeleton organization 1.197E-2 3.807E-2
2.105E-1
1.000E0
 2 464
44 GO:0060487 lung epithelial cell differentiation 1.234E-2 3.807E-2
2.105E-1
1.000E0
 1 33
45 GO:0002026 regulation of the force of heart contraction 1.234E-2 3.807E-2
2.105E-1
1.000E0
 1 33
46 GO:0042326 negative regulation of phosphorylation 1.242E-2 3.807E-2
2.105E-1
1.000E0
 2 473
47 GO:0060479 lung cell differentiation 1.271E-2 3.814E-2
2.109E-1
1.000E0
 1 34
48 GO:1902532 negative regulation of intracellular signal transduction 1.329E-2 3.872E-2
2.141E-1
1.000E0
 2 490
49 GO:0051293 establishment of spindle localization 1.346E-2 3.872E-2
2.141E-1
1.000E0
 1 36
50 GO:0007212 dopamine receptor signaling pathway 1.457E-2 4.109E-2
2.272E-1
1.000E0
 1 39
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 42 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000922 spindle pole 9.918E-4 1.833E-2
7.930E-2
 4.165E-2 2 133
2 GO:0043197 dendritic spine 1.276E-3 1.833E-2
7.930E-2
5.357E-2
 2 151
3 GO:0044309 neuron spine 1.309E-3 1.833E-2
7.930E-2
5.499E-2
 2 153
4 GO:0097431 mitotic spindle pole 5.131E-3 4.175E-2
1.806E-1
2.155E-1
 1 14
5 GO:0005819 spindle 5.180E-3 4.175E-2
1.806E-1
2.176E-1
 2 308
6 GO:0097440 apical dendrite 6.593E-3 4.175E-2
1.806E-1
2.769E-1
 1 18
7 GO:0097381 photoreceptor disc membrane 6.958E-3 4.175E-2
1.806E-1
2.922E-1
 1 19
Show 2 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 28 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0030511 Bradyopsia 8.497E-4 2.379E-2
9.343E-2
 2.379E-2 1 2
2 HP:0002700 Large foramen magnum 2.548E-3 3.567E-2
1.401E-1
7.135E-2
 1 6
3 HP:0007033 Cerebellar dysplasia 8.058E-3 4.004E-2
1.573E-1
2.256E-1
 1 19
4 HP:0002699 Abnormality of the foramen magnum 8.904E-3 4.004E-2
1.573E-1
2.493E-1
 1 21
5 HP:0100700 Abnormal arachnoid mater morphology 8.904E-3 4.004E-2
1.573E-1
2.493E-1
 1 21
6 HP:0100702 Arachnoid cyst 8.904E-3 4.004E-2
1.573E-1
2.493E-1
 1 21
7 HP:0001338 Partial agenesis of the corpus callosum 1.102E-2 4.004E-2
1.573E-1
3.085E-1
 1 26
8 HP:0002281 Gray matter heterotopias 1.144E-2 4.004E-2
1.573E-1
3.203E-1
 1 27
Show 3 more annotations

5: Mouse Phenotype [Display Chart] 6 input genes in category / 234 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 7 input genes in category / 65 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00315 RGS SMART 1.891E-16 4.916E-15 2.340E-14 1.229E-14 6 35
2 PF00615 RGS Pfam 1.891E-16 4.916E-15 2.340E-14 1.229E-14 6 35
3 PS50132 RGS PROSITE 2.269E-16 4.916E-15 2.340E-14 1.475E-14 6 36
4 IPR016137 RGS InterPro 3.800E-16 6.175E-15 2.939E-14 2.470E-14 6 39
5 IPR024066 RGS subdom1 InterPro 2.872E-14 3.112E-13 1.481E-12 1.867E-12 5 22
6 1.10.196.10 - Gene3D 2.872E-14 3.112E-13 1.481E-12 1.867E-12 5 22
7 PS50877 GOLOCO PROSITE 1.117E-9 7.262E-9 3.456E-8 7.262E-8 3 7
8 PF02188 GoLoco Pfam 1.117E-9 7.262E-9 3.456E-8 7.262E-8 3 7
9 IPR003109 GoLoco motif InterPro 1.117E-9 7.262E-9 3.456E-8 7.262E-8 3 7
10 SM00390 GoLoco SMART 1.117E-9 7.262E-9 3.456E-8 7.262E-8 3 7
11 PF02196 RBD Pfam 1.794E-6 1.060E-5 5.044E-5 1.166E-4 2 6
12 SM00455 RBD SMART 2.511E-6 1.166E-5 5.548E-5 1.632E-4 2 7
13 PS50898 RBD PROSITE 2.511E-6 1.166E-5 5.548E-5 1.632E-4 2 7
14 IPR003116 RBD dom InterPro 2.511E-6 1.166E-5 5.548E-5 1.632E-4 2 7
15 IPR030776 RGS14 InterPro 3.736E-4 1.619E-3 7.706E-3 2.429E-2 1 1
16 IPR029071 Ubiquitin-rel dom InterPro 1.950E-3 7.923E-3 3.771E-2
1.268E-1
 2 184
17 IPR000239 GPCR kinase InterPro 2.613E-3 9.991E-3 4.755E-2
1.698E-1
 1 7
18 PF13176 TPR 7 Pfam 3.731E-3 1.347E-2
6.412E-2
2.425E-1
 1 10
19 PF00631 G-gamma Pfam 5.964E-3 1.615E-2
7.687E-2
3.876E-1
 1 16
20 IPR001770 Gprotein-gamma InterPro 5.964E-3 1.615E-2
7.687E-2
3.876E-1
 1 16
21 4.10.260.10 - Gene3D 5.964E-3 1.615E-2
7.687E-2
3.876E-1
 1 16
22 IPR015898 G-protein gamma-like dom InterPro 5.964E-3 1.615E-2
7.687E-2
3.876E-1
 1 16
23 SM00224 GGL SMART 5.964E-3 1.615E-2
7.687E-2
3.876E-1
 1 16
24 PS50058 G PROTEIN GAMMA PROSITE 5.964E-3 1.615E-2
7.687E-2
3.876E-1
 1 16
25 PF00610 DEP Pfam 8.192E-3 1.919E-2
9.135E-2
5.325E-1
 1 22
26 PS50186 DEP PROSITE 8.192E-3 1.919E-2
9.135E-2
5.325E-1
 1 22
27 SM00049 DEP SMART 8.192E-3 1.919E-2
9.135E-2
5.325E-1
 1 22
28 2.30.29.30 - Gene3D 8.512E-3 1.919E-2
9.135E-2
5.533E-1
 2 391
29 IPR000591 DEP dom InterPro 8.563E-3 1.919E-2
9.135E-2
5.566E-1
 1 23
30 IPR011993 PH dom-like InterPro 1.009E-2 2.186E-2
1.040E-1
6.557E-1
 2 427
31 PS01179 PID PROSITE 1.190E-2 2.495E-2
1.187E-1
7.733E-1
 1 32
32 SM00462 PTB SMART 1.485E-2 2.998E-2
1.427E-1
9.654E-1
 1 40
33 IPR006020 PTB/PI dom InterPro 1.522E-2 2.998E-2
1.427E-1
9.894E-1
 1 41
34 PF13181 TPR 8 Pfam 1.964E-2 3.644E-2
1.734E-1
1.000E0
 1 53
35 SM00133 S TK X SMART 2.074E-2 3.644E-2
1.734E-1
1.000E0
 1 56
36 PS51285 AGC KINASE CTER PROSITE 2.074E-2 3.644E-2
1.734E-1
1.000E0
 1 56
37 IPR000961 AGC-kinase C InterPro 2.074E-2 3.644E-2
1.734E-1
1.000E0
 1 56
Show 32 more annotations

7: Pathway [Display Chart] 7 input genes in category / 55 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PantherDB 3.202E-14 1.761E-12 8.091E-12 1.761E-12 7 150
2 P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway PantherDB 3.046E-12 8.376E-11 3.848E-10 1.675E-10 6 111
3 1269576 G alpha (i) signalling events BioSystems: REACTOME 4.733E-6 8.676E-5 3.986E-4 2.603E-4 4 243
4 1269577 G alpha (z) signalling events BioSystems: REACTOME 3.019E-4 4.151E-3 1.907E-2 1.661E-2 2 48

8: Pubmed [Display Chart] 7 input genes in category / 740 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26987813 Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o. Pubmed 5.922E-15 4.382E-12 3.148E-11 4.382E-12 4 6
2 11829488 Evolution of the regulators of G-protein signaling multigene family in mouse and human. Pubmed 7.271E-14 2.690E-11 1.933E-10 5.381E-11 5 51
3 20627871 Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma. Pubmed 9.389E-13 2.316E-10 1.664E-9 6.948E-10 4 17
4 11342430 A novel regulator of G-protein signaling bearing GAP activity for Galphai and Galphaq in megakaryocytes. Pubmed 1.529E-12 2.829E-10 2.032E-9 1.131E-9 4 19
5 10869340 Novel alternative splicing and nuclear localization of human RGS12 gene products. Pubmed 2.879E-8 2.663E-6 1.914E-5 2.131E-5 2 2
6 15525537 RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. Pubmed 2.879E-8 2.663E-6 1.914E-5 2.131E-5 2 2
7 16145674 Differential expression of regulator of G-protein signaling R12 subfamily members during mouse development. Pubmed 2.879E-8 2.663E-6 1.914E-5 2.131E-5 2 2
8 9168931 Molecular cloning and expression analysis of rat Rgs12 and Rgs14. Pubmed 2.879E-8 2.663E-6 1.914E-5 2.131E-5 2 2
9 10727532 Selective regulation of Gq signaling by G protein-coupled receptor kinase 2: direct interaction of kinase N terminus with activated galphaq. Pubmed 1.727E-7 1.420E-5 1.020E-4 1.278E-4 2 4
10 11387333 RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity. Pubmed 2.879E-7 2.130E-5 1.530E-4 2.130E-4 2 5
11 29229865 Daple coordinates organ-wide and cell-intrinsic polarity to pattern inner-ear hair bundles. Pubmed 3.451E-6 2.322E-4 1.668E-3 2.554E-3 2 16
12 24561123 CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human βâ??-adrenergic receptor. Pubmed 4.413E-5 5.447E-4 3.913E-3 3.266E-2 2 56
13 12920194 Recruitment of RGS2 and RGS4 to the plasma membrane by G proteins and receptors reflects functional interactions. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
14 27720394 G Protein-coupled Receptor Kinase 2 (GRK2) Promotes Breast Tumorigenesis Through a HDAC6-Pin1 Axis. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
15 9660778 Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
16 19636837 Backbone and sidechain 1H, 13C and 15N resonance assignments of the RGS domain from human RGS14. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
17 19620130 The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
18 17588543 Ethnic stratification of the association of RGS4 variants with antipsychotic treatment response in schizophrenia. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
19 22253691 An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
20 26234354 [The Role of GRK2 and Its Potential as a New Therapeutic Target in Diabetic Vascular Complications]. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
21 24191280 Increased nitric oxide bioavailability in adult GRK2 hemizygous mice protects against angiotensin II-induced hypertension. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
22 17517892 GRK2 negatively regulates glycogen synthesis in mouse liver FL83B cells. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
23 12435819 Reduction of G protein-coupled receptor kinase 2 expression in U-937 cells attenuates H2 histamine receptor desensitization and induces cell maturation. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
24 20493668 Reduced platelet G protein-coupled receptor kinase 2 in major depressive disorder: antidepressant treatment-induced upregulation of GRK2 protein discriminates between responder and non-responder patients. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
25 27091895 Pivotal Role of Regulator of G-protein Signaling 12 in Pathological Cardiac Hypertrophy. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
26 16356165 Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293beta2 cells and cardiac myocytes. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
27 15585587 Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
28 14732600 Support for RGS4 as a susceptibility gene for schizophrenia. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
29 25150149 RGS9-2 modulates sensory and mood related symptoms of neuropathic pain. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
30 9187265 A dominant negative mutant of the G protein-coupled receptor kinase 2 selectively attenuates adenosine A2 receptor desensitization. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
31 20385802 RGS4 is a negative regulator of insulin release from pancreatic beta-cells in vitro and in vivo. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
32 22516294 GRK2 contribution to the regulation of energy expenditure and brown fat function. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
33 23904266 G protein-coupled receptor kinase 2 (GRK2) is localized to centrosomes and mediates epidermal growth factor-promoted centrosomal separation. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
34 17000469 Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
35 12869383 Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
36 28776200 Regulator of G protein signaling 14 (RGS14) is expressed pre- and postsynaptically in neurons of hippocampus, basal ganglia, and amygdala of monkey and human brain. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
37 24702056 GRK2 in the heart: a GPCR kinase and beyond. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
38 28882814 Opsin 3 and 4 mediate light-induced pulmonary vasorelaxation that is potentiated by G protein-coupled receptor kinase 2 inhibition. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
39 19912469 Distribution of RGS9-2 in neurons of the mouse striatum. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
40 22753418 Amino-terminal cysteine residues differentially influence RGS4 protein plasma membrane targeting, intracellular trafficking, and function. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
41 21111235 Nonenzymatic rapid control of GIRK channel function by a G protein-coupled receptor kinase. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
42 19041089 Expression of RGS4 splice variants in dorsolateral prefrontal cortex of schizophrenic and bipolar disorder patients. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
43 20430014 Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
44 17301167 Allelic variation in RGS4 impacts functional and structural connectivity in the human brain. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
45 16526029 Evaluation of RGS4 as a candidate gene for schizophrenia. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
46 15917656 RGS14 is a microtubule-associated protein. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
47 16984558 Decreased expression of G protein-coupled receptor kinases in the detrusor smooth muscle of human urinary bladder with outlet obstruction. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
48 26447102 G-protein-coupled receptor kinase 2 and endothelial dysfunction: molecular insights and pathophysiological mechanisms. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
49 19878719 RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
50 17408432 A role for G protein-coupled receptor kinase 2 in mechanical allodynia. Pubmed 1.833E-4 5.447E-4 3.913E-3
1.356E-1
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 152 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:GNAI1 GNAI1 interactions 1.258E-10 1.912E-8 1.071E-7 1.912E-8 5 103
2 int:GNAO1 GNAO1 interactions 6.907E-9 5.249E-7 2.942E-6 1.050E-6 4 68
3 int:GNAI3 GNAI3 interactions 5.428E-8 2.750E-6 1.541E-5 8.250E-6 4 113
4 int:GNAI2 GNAI2 interactions 1.699E-7 6.457E-6 3.619E-5 2.583E-5 4 150
5 int:PLCB1 PLCB1 interactions 4.336E-5 1.318E-3 7.388E-3 6.591E-3 2 26
6 int:ADRB2 ADRB2 interactions 1.049E-4 2.658E-3 1.490E-2 1.595E-2 3 260
7 int:GNAQ GNAQ interactions 6.513E-4 1.414E-2
7.926E-2
9.899E-2
 2 100
8 int:RGS9BP RGS9BP interactions 7.907E-4 1.502E-2
8.420E-2
1.202E-1
 1 2
9 int:HRAS HRAS interactions 1.399E-3 2.363E-2
1.325E-1
2.127E-1
 2 147
10 int:GPR17 GPR17 interactions 1.581E-3 2.403E-2
1.347E-1
2.403E-1
 1 4
11 int:AASDH AASDH interactions 2.370E-3 2.475E-2
1.387E-1
3.603E-1
 1 6
12 int:GNAT1 GNAT1 interactions 2.370E-3 2.475E-2
1.387E-1
3.603E-1
 1 6
13 int:INSC INSC interactions 2.370E-3 2.475E-2
1.387E-1
3.603E-1
 1 6
14 int:RGS7BP RGS7BP interactions 2.765E-3 2.475E-2
1.387E-1
4.203E-1
 1 7
15 int:PDC PDC interactions 3.160E-3 2.475E-2
1.387E-1
4.803E-1
 1 8
16 int:GUCY2D GUCY2D interactions 3.160E-3 2.475E-2
1.387E-1
4.803E-1
 1 8
17 int:CCR4 CCR4 interactions 3.160E-3 2.475E-2
1.387E-1
4.803E-1
 1 8
18 int:FPR1 FPR1 interactions 3.554E-3 2.475E-2
1.387E-1
5.402E-1
 1 9
19 int:RGS9 RGS9 interactions 3.948E-3 2.475E-2
1.387E-1
6.001E-1
 1 10
20 int:PABPC4L PABPC4L interactions 3.948E-3 2.475E-2
1.387E-1
6.001E-1
 1 10
21 int:PDE6G PDE6G interactions 4.342E-3 2.475E-2
1.387E-1
6.600E-1
 1 11
22 int:PRPF40B PRPF40B interactions 4.736E-3 2.475E-2
1.387E-1
7.199E-1
 1 12
23 int:PRKACA PRKACA interactions 5.072E-3 2.475E-2
1.387E-1
7.709E-1
 2 283
24 int:PTAFR PTAFR interactions 5.130E-3 2.475E-2
1.387E-1
7.797E-1
 1 13
25 int:MC4R MC4R interactions 5.130E-3 2.475E-2
1.387E-1
7.797E-1
 1 13
26 int:RND2 RND2 interactions 5.130E-3 2.475E-2
1.387E-1
7.797E-1
 1 13
27 int:BDKRB2 BDKRB2 interactions 5.524E-3 2.475E-2
1.387E-1
8.396E-1
 1 14
28 int:GRM2 GRM2 interactions 5.917E-3 2.475E-2
1.387E-1
8.994E-1
 1 15
29 int:RGS4 RGS4 interactions 5.917E-3 2.475E-2
1.387E-1
8.994E-1
 1 15
30 int:OSTM1 OSTM1 interactions 5.917E-3 2.475E-2
1.387E-1
8.994E-1
 1 15
31 int:RHO RHO interactions 5.917E-3 2.475E-2
1.387E-1
8.994E-1
 1 15
32 int:LCE2A LCE2A interactions 5.917E-3 2.475E-2
1.387E-1
8.994E-1
 1 15
33 int:ADRA2A ADRA2A interactions 5.917E-3 2.475E-2
1.387E-1
8.994E-1
 1 15
34 int:RND3 RND3 interactions 6.311E-3 2.475E-2
1.387E-1
9.592E-1
 1 16
35 int:RCVRN RCVRN interactions 6.311E-3 2.475E-2
1.387E-1
9.592E-1
 1 16
36 int:LCE3C LCE3C interactions 6.704E-3 2.475E-2
1.387E-1
1.000E0
 1 17
37 int:GRK3 GRK3 interactions 6.704E-3 2.475E-2
1.387E-1
1.000E0
 1 17
38 int:GABBR1 GABBR1 interactions 6.704E-3 2.475E-2
1.387E-1
1.000E0
 1 17
39 int:RND1 RND1 interactions 6.704E-3 2.475E-2
1.387E-1
1.000E0
 1 17
40 int:RUFY3 RUFY3 interactions 7.097E-3 2.475E-2
1.387E-1
1.000E0
 1 18
41 int:GPSM2 GPSM2 interactions 7.097E-3 2.475E-2
1.387E-1
1.000E0
 1 18
42 int:RGS17 RGS17 interactions 7.490E-3 2.475E-2
1.387E-1
1.000E0
 1 19
43 int:KRIT1 KRIT1 interactions 7.490E-3 2.475E-2
1.387E-1
1.000E0
 1 19
44 int:PPWD1 PPWD1 interactions 7.490E-3 2.475E-2
1.387E-1
1.000E0
 1 19
45 int:CACNA1B CACNA1B interactions 7.490E-3 2.475E-2
1.387E-1
1.000E0
 1 19
46 int:RGS12 RGS12 interactions 7.490E-3 2.475E-2
1.387E-1
1.000E0
 1 19
47 int:RGS14 RGS14 interactions 7.883E-3 2.510E-2
1.407E-1
1.000E0
 1 20
48 int:SMCP SMCP interactions 8.276E-3 2.510E-2
1.407E-1
1.000E0
 1 21
49 int:ARL4C ARL4C interactions 8.668E-3 2.510E-2
1.407E-1
1.000E0
 1 22
50 int:RASGRF1 RASGRF1 interactions 9.061E-3 2.510E-2
1.407E-1
1.000E0
 1 23
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17q24 17q24 2.018E-3 1.413E-2 3.663E-2 1.413E-2 1 10
2 6q25.3 6q25.3 7.048E-3 1.967E-2
5.101E-2
 4.933E-2 1 35
3 1q23.3 1q23.3 1.026E-2 1.967E-2
5.101E-2
7.179E-2
 1 51
4 11q13.1 11q13.1 1.345E-2 1.967E-2
5.101E-2
9.418E-2
 1 67
5 1p13.3 1p13.3 1.405E-2 1.967E-2
5.101E-2
9.837E-2
 1 70
6 4p16.3 4p16.3 1.824E-2 2.042E-2
5.295E-2
1.276E-1
 1 91
7 5q35.3 5q35.3 2.042E-2 2.042E-2
5.295E-2
1.429E-1
 1 102
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 43 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 720 Regulators of G-protein signaling genenames.org 2.570E-14 1.285E-13 2.934E-13 1.285E-13 5 21

13: Coexpression [Display Chart] 7 input genes in category / 753 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19286929-SuppTable2n Mouse Lung Rangasamy09 254genes GeneSigDB 3.695E-5 2.782E-2
2.004E-1
 2.782E-2 3 239
2 16204010-SuppTable Human Ovarian Spentzos05 93genes GeneSigDB 1.199E-4 3.462E-2
2.494E-1
9.028E-2
 2 56
3 20081812-Table3 Human Lymphoma Sagaert10 167genes GeneSigDB 3.753E-4 3.462E-2
2.494E-1
2.826E-1
 2 99
4 M1514 Down-regulated genes in the signature of adipose stromal cells (ADSC) immortalized by forced expression of telomerase (TERT) [GeneID=7015]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.984E-4 3.462E-2
2.494E-1
3.000E-1
 2 102
5 M2451 Genes down-regulated after 1 h of TGFB1 [GeneID=7040] stimulation in MEF cells (embryonic fibroblast) with NFIC [GeneID=4782] knockout vs wild type MEFs. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.301E-4 3.462E-2
2.494E-1
3.239E-1
 2 106
6 20035825-TableS2b Mouse Lung Mikkonen10 134genes GeneSigDB 5.599E-4 3.462E-2
2.494E-1
4.216E-1
 2 121
7 M7722 Genes up-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 3h versus 24h. MSigDB C7: Immunologic Signatures (v6.0) 9.635E-4 3.462E-2
2.494E-1
7.255E-1
 2 159
8 M6110 Genes down-regulated in patients at the incipient stage of Alzheimer's disease. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.037E-3 3.462E-2
2.494E-1
7.808E-1
 2 165
9 M6882 Genes up-regulated in monocytes after HCMV infection: untreated versus Ly294002 [PubChem=3973]. MSigDB C7: Immunologic Signatures (v6.0) 1.152E-3 3.462E-2
2.494E-1
8.674E-1
 2 174
10 M7706 Genes up-regulated in CD4 [GeneID=920] T cells: control versus Ro 41-5253 [PubChem=5312120]. MSigDB C7: Immunologic Signatures (v6.0) 1.473E-3 3.462E-2
2.494E-1
1.000E0
 2 197
11 M8400 Genes down-regulated in brain microglia versus spleen CD8- dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 3.462E-2
2.494E-1
1.000E0
 2 198
12 M8473 Genes up-regulated in splenic B lymphocytes: wildtype versus KLF3 [GeneID=51274] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.462E-2
2.494E-1
1.000E0
 2 199
13 M9997 Genes up-regulated in dendritic cells: CD8A [GeneID=925] versus ITGAM+ [GeneID=3684]. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.462E-2
2.494E-1
1.000E0
 2 199
14 M4464 Genes up-regulated in comparison of neutrophils versus dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 3.462E-2
2.494E-1
1.000E0
 2 199
15 M5738 Genes down-regulated in comparison of lymph node regulatory T cells versus thymus regulatory T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
16 M3706 Genes down-regulated in comparison of control dendritic cells (DC) at 0 h versus those stimulated with poly(I:C) (TLR3 agonist) at 0.5 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
17 M7754 Genes up-regulated in macrophages: untreated versus 24h after M. bovis BCG infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
18 M3550 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus activated regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
19 M7682 Genes up-regulated in ankle joints: SPHK1 [GeneID=8877] versus wildtype over-expressing TNF [GeneID=7124]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
20 M8959 Genes up-regulated in lymph node from aged PPARG [GeneID=5468] knockout mice: T reg versus T conv. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
21 M6580 Genes down-regulated in ITGAM+ [GeneID=3684] cells from spleens of tumor bearing mice: processed immediately versus those incubated for 24h in complete medium. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
22 M4021 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
23 M7758 Genes up-regulated macrophages with MYD88 [GeneID=4615] knockout: untreated versus 12h after M. bovis BCG infection. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
24 M3563 Genes down-regulated in comparison of resting regulatory T cell (Treg) versus activated regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
25 M4512 Genes down-regulated in comparison of stimulated CD4 [GeneID=920] Th1 cells at 48 h versus stimulated CD4 [GeneID=920] Th2 cells at 48 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
26 M5399 Genes up-regulated in comparison of eosinophils versus dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
27 M4048 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 4 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
28 M4024 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
29 M3943 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 6 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
30 M3165 Genes down-regulated in comparison of Th2 cells versus Th17 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
31 M9386 Genes up-regulated in day 40 memory B cells versus day 40 germinal center B cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
32 M9674 Genes up-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 10h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
33 M3557 Genes down-regulated in comparison of PTPRC- [GeneID=5788] CD4 [GeneID=920] T cells versus activated regulatory T cell (Treg). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 3.462E-2
2.494E-1
1.000E0
 2 200
34 17894856-SuppList4 Human Breast Yu07 298genes GeneSigDB 1.671E-3 3.701E-2
2.665E-1
1.000E0
 2 210
35 M11234 Genes down-regulated in polymorphonuclear neutrophilic granulocytes (PMNs) attracted to skin wounds. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.915E-3 4.119E-2
2.967E-1
1.000E0
 2 225
Show 30 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 565 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/Gad1,Gad2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/Gad1,Gad2 BrainMap 1.791E-5 2.348E-3 1.623E-2 1.012E-2 3 177
2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup9 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup9 BrainMap 2.044E-5 2.348E-3 1.623E-2 1.155E-2 3 185
3 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Top 200 BrainMap 2.044E-5 2.348E-3 1.623E-2 1.155E-2 3 185
4 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Gad1,Gad2 Neuron.mixed excitatory.Gad1,Gad2 Overall Top 200 Genes BrainMap 2.044E-5 2.348E-3 1.623E-2 1.155E-2 3 185
5 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Overall Top 200 Genes BrainMap 2.078E-5 2.348E-3 1.623E-2 1.174E-2 3 186
6 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 GlobusPallidus Top 200 Genes BrainMap 8.549E-5 6.074E-3 4.200E-2 4.830E-2 3 299
7 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap 9.700E-5 6.074E-3 4.200E-2
5.481E-2
 3 312
8 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Gad1,Gad2 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Gad1,Gad2 Top 200 Genes 9.793E-5 6.074E-3 4.200E-2
5.533E-2
 3 313
9 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory Neuron.inhibitory Subtype Neuron.inhibitory.Gad1,Gad2 Top 200 Genes BrainMap 1.026E-4 6.074E-3 4.200E-2
5.799E-2
 3 318
10 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap 1.075E-4 6.074E-3 4.200E-2
6.074E-2
 3 323
11 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 Striatum Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Subtype Inhibitory.subGroup9 Striatum Top 200 Genes BrainMap 1.307E-4 6.712E-3 4.641E-2
7.383E-2
 3 345
12 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Top 200 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Top 200 BrainMap 3.016E-4 1.363E-2
9.427E-2
1.704E-1
 3 458
13 Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/mid-fetal/CM a Human Kidney Development/Human Kidney Fetal Kidney Cell Atlas: (Tang et al 2018)/Human/Cell Subclass of Age of Cell Class of Tissue (subtype)/Cap mesenchyme (CM)/mid-fetal/CM a Fetal, Development 3.207E-4 1.363E-2
9.427E-2
1.812E-1
 1 1
14 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap 3.378E-4 1.363E-2
9.427E-2
1.909E-1
 3 476
15 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/3/4 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/3/4 TCGA-Breast 6.413E-4 2.415E-2
1.670E-1
3.623E-1
 1 2
16 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/Striatum BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Car4/Endothelial Stalk.Flt1.Car4/Striatum BrainMap 8.517E-4 3.008E-2
2.080E-1
4.812E-1
 2 141
17 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Oligodendrocyte/Oligodendrocyte/Pdgfa-hi oligodendrocytes/Tnf//Ptgds BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Oligodendrocyte/Oligodendrocyte/Pdgfa-hi oligodendrocytes/Tnf//Ptgds BrainMap 1.122E-3 3.090E-2
2.137E-1
6.338E-1
 2 162
18 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Grm1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Grm1 BrainMap 1.352E-3 3.090E-2
2.137E-1
7.637E-1
 2 178
19 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Overall Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Overall Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.367E-3 3.090E-2
2.137E-1
7.722E-1
 2 179
20 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Top 200 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hNProg Top 200 GSE76381_EmbryoMoleculeCountsPMLog2 1.367E-3 3.090E-2
2.137E-1
7.722E-1
 2 179
21 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Htr1b BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Htr1b BrainMap 1.382E-3 3.090E-2
2.137E-1
7.808E-1
 2 180
22 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup7/Adora2a BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup7/Adora2a BrainMap 1.397E-3 3.090E-2
2.137E-1
7.894E-1
 2 181
23 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Top 200 BrainMap 1.474E-3 3.090E-2
2.137E-1
8.331E-1
 2 186
24 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Gad1,Gad2 Neuron.inhibitory.Gad1,Gad2 Overall Top 200 Genes BrainMap 1.474E-3 3.090E-2
2.137E-1
8.331E-1
 2 186
25 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Chat BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/inhibitory/subGroup2/Chat BrainMap 1.490E-3 3.090E-2
2.137E-1
8.420E-1
 2 187
26 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic D cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Pancreas/pancreatic D cell Tabula Muris Consortium 1.490E-3 3.090E-2
2.137E-1
8.420E-1
 2 187
27 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Ccnd1/Mural.Rgs5.Acta2.Ccnd1/FrontalCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Mural/Mural/Acta2/Acta2,Rgs5//Ccnd1/Mural.Rgs5.Acta2.Ccnd1/FrontalCortex BrainMap 1.506E-3 3.090E-2
2.137E-1
8.509E-1
 2 188
28 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap 1.554E-3 3.090E-2
2.137E-1
8.779E-1
 2 191
29 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Dcn/Endothelial Tip.Dcn/Striatum BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Tip/Endothelial Tip/Endothelial Tip/Dcn//Dcn/Endothelial Tip.Dcn/Striatum BrainMap 1.586E-3 3.090E-2
2.137E-1
8.962E-1
 2 193
Show 24 more annotations

15: Computational [Display Chart] 5 input genes in category / 25 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 334 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-496.2:TargetScan hsa-miR-496.2 TargetScan 6.917E-5 1.125E-2
7.185E-2
 2.310E-2 2 132
2 hsa-miR-924:PITA hsa-miR-924:PITA TOP PITA 8.462E-5 1.125E-2
7.185E-2
 2.826E-2 2 146
3 hsa-miR-4465:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.433E-4 1.125E-2
7.185E-2
 4.785E-2 2 190
4 hsa-miR-1297:Functional MTI Functional MTI miRTarbase 1.493E-4 1.125E-2
7.185E-2
 4.988E-2 2 194
5 hsa-miR-500b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.683E-4 1.125E-2
7.185E-2
5.623E-2
 2 206
6 hsa-miR-127-3p:mirSVR lowEffct hsa-miR-127-3p:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 5.695E-4 2.032E-2
1.298E-1
1.902E-1
 2 380
7 hsa-miR-26a-5p:Functional MTI Functional MTI miRTarbase 8.211E-4 2.032E-2
1.298E-1
2.743E-1
 2 457
8 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 8.211E-4 2.032E-2
1.298E-1
2.743E-1
 2 457
9 hsa-miR-1913:mirSVR highEffct hsa-miR-1913:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.354E-4 2.032E-2
1.298E-1
2.790E-1
 2 461
10 hsa-miR-654-5p:mirSVR highEffct hsa-miR-654-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.717E-4 2.032E-2
1.298E-1
2.911E-1
 2 471
11 hsa-miR-1297:PITA hsa-miR-1297:PITA TOP PITA 8.790E-4 2.032E-2
1.298E-1
2.936E-1
 2 473
12 hsa-miR-26a:PITA hsa-miR-26a:PITA TOP PITA 8.790E-4 2.032E-2
1.298E-1
2.936E-1
 2 473
13 hsa-miR-26b:PITA hsa-miR-26b:PITA TOP PITA 8.790E-4 2.032E-2
1.298E-1
2.936E-1
 2 473
14 hsa-miR-3141:mirSVR lowEffct hsa-miR-3141:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.087E-4 2.032E-2
1.298E-1
3.035E-1
 2 481
15 hsa-miR-541:mirSVR highEffct hsa-miR-541:mirSVR nonconserved highEffect-0.5 MicroRNA.org 9.125E-4 2.032E-2
1.298E-1
3.048E-1
 2 482
16 hsa-miR-3912-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.453E-3 3.032E-2
1.938E-1
4.852E-1
 1 15
17 hsa-miR-127-3p:Functional MTI Functional MTI miRTarbase 2.807E-3 4.303E-2
2.749E-1
9.375E-1
 1 29
18 hsa-miR-5687:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.903E-3 4.303E-2
2.749E-1
9.697E-1
 1 30
19 hsa-miR-151-5p:PITA hsa-miR-151-5p:PITA TOP PITA 2.903E-3 4.303E-2
2.749E-1
9.697E-1
 1 30
20 CTCTATG,MIR-368:MSigDB CTCTATG,MIR-368:MSigDB MSigDB 3.676E-3 4.303E-2
2.749E-1
1.000E0
 1 38
21 hsa-miR-4474-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.449E-3 4.303E-2
2.749E-1
1.000E0
 1 46
22 hsa-miR-7705:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.028E-3 4.303E-2
2.749E-1
1.000E0
 1 52
23 hsa-miR-7704:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.125E-3 4.303E-2
2.749E-1
1.000E0
 1 53
24 hsa-miR-508-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.703E-3 4.303E-2
2.749E-1
1.000E0
 1 59
25 hsa-miR-4711-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.703E-3 4.303E-2
2.749E-1
1.000E0
 1 59
26 hsa-miR-103b:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.896E-3 4.303E-2
2.749E-1
1.000E0
 1 61
27 hsa-miR-569:Functional MTI Functional MTI miRTarbase 6.185E-3 4.303E-2
2.749E-1
1.000E0
 1 64
28 hsa-miR-4704-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.378E-3 4.303E-2
2.749E-1
1.000E0
 1 66
29 hsa-miR-10a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.474E-3 4.303E-2
2.749E-1
1.000E0
 1 67
30 hsa-miR-6733-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.571E-3 4.303E-2
2.749E-1
1.000E0
 1 68
31 hsa-miR-296-5p:PITA hsa-miR-296-5p:PITA TOP PITA 6.667E-3 4.303E-2
2.749E-1
1.000E0
 1 69
32 AATGGAG,MIR-136:MSigDB AATGGAG,MIR-136:MSigDB MSigDB 6.956E-3 4.303E-2
2.749E-1
1.000E0
 1 72
33 hsa-miR-3660:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.956E-3 4.303E-2
2.749E-1
1.000E0
 1 72
34 CTCAAGA,MIR-526B:MSigDB CTCAAGA,MIR-526B:MSigDB MSigDB 6.956E-3 4.303E-2
2.749E-1
1.000E0
 1 72
35 hsa-miR-4526:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.052E-3 4.303E-2
2.749E-1
1.000E0
 1 73
36 hsa-miR-323a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.245E-3 4.303E-2
2.749E-1
1.000E0
 1 75
37 hsa-miR-3129-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.630E-3 4.303E-2
2.749E-1
1.000E0
 1 79
38 hsa-miR-593-5p:Functional MTI Functional MTI miRTarbase 7.726E-3 4.303E-2
2.749E-1
1.000E0
 1 80
39 hsa-miR-936:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.303E-2
2.749E-1
1.000E0
 1 82
40 hsa-miR-642a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.303E-2
2.749E-1
1.000E0
 1 82
41 hsa-miR-642b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.303E-2
2.749E-1
1.000E0
 1 82
42 hsa-miR-199b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.919E-3 4.303E-2
2.749E-1
1.000E0
 1 82
43 hsa-miR-222-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 4.303E-2
2.749E-1
1.000E0
 1 83
44 hsa-miR-6854-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.015E-3 4.303E-2
2.749E-1
1.000E0
 1 83
45 hsa-miR-886-3p:mirSVR highEffct hsa-miR-886-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.208E-3 4.303E-2
2.749E-1
1.000E0
 1 85
46 GGCAGTG,MIR-324-3P:MSigDB GGCAGTG,MIR-324-3P:MSigDB MSigDB 8.400E-3 4.303E-2
2.749E-1
1.000E0
 1 87
47 hsa-miR-1234:mirSVR highEffct hsa-miR-1234:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.496E-3 4.303E-2
2.749E-1
1.000E0
 1 88
48 hsa-miR-5190:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.592E-3 4.303E-2
2.749E-1
1.000E0
 1 89
49 hsa-miR-939:PITA hsa-miR-939:PITA TOP PITA 8.689E-3 4.303E-2
2.749E-1
1.000E0
 1 90
50 hsa-miR-4742-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.785E-3 4.303E-2
2.749E-1
1.000E0
 1 91
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 3535 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5086 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.619E-5 3.570E-3 3.123E-2
5.722E-2
 3 179
2 1228 UP geldanamycin; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.816E-5 3.570E-3 3.123E-2
6.418E-2
 3 186
3 6552 DN prostaglandin E2; Down 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.091E-5 3.570E-3 3.123E-2
7.392E-2
 3 195
4 7448 UP Bacitracin [1405-87-4]; Up 200; 2.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.091E-5 3.570E-3 3.123E-2
7.392E-2
 3 195
5 5058 UP Homatropine hydrobromide (R,S) [51-56-9]; Up 200; 11.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.123E-5 3.570E-3 3.123E-2
7.506E-2
 3 196
6 4236 DN Gabazine [105538-73-6]; Down 200; 10.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.123E-5 3.570E-3 3.123E-2
7.506E-2
 3 196
7 3247 DN Cefixime [79350-37-1]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.156E-5 3.570E-3 3.123E-2
7.621E-2
 3 197
8 5100 DN Cyclizine hydrochloride [303-25-3]; Down 200; 13.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.156E-5 3.570E-3 3.123E-2
7.621E-2
 3 197
9 5972 UP pioglitazone HCl; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.156E-5 3.570E-3 3.123E-2
7.621E-2
 3 197
10 6497 UP L(-)-vesamicol hydrochloride [112709-59-8]; Up 200; 13.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.156E-5 3.570E-3 3.123E-2
7.621E-2
 3 197
11 7259 UP Hydroflumethiazide [135-09-1]; Up 200; 12uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.156E-5 3.570E-3 3.123E-2
7.621E-2
 3 197
12 3551 UP Piperidolate hydrochloride [129-77-1]; Up 200; 11.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.156E-5 3.570E-3 3.123E-2
7.621E-2
 3 197
13 2125 UP Iproniazide phosphate [305-33-9]; Up 200; 14.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
14 5080 UP Lobelanidine hydrochloride [6112-86-3]; Up 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
15 5850 UP Vidarabine [5536-17-4]; Up 200; 15uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
16 4088 UP Tolmetin sodium salt dihydrate [64490-92-2]; Up 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
17 2118 UP Aztreonam [78110-38-0]; Up 200; 9.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
18 3703 UP Folinic acid calcium salt [6035-45-6]; Up 200; 7.8uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
19 6033 UP Delcorine; Up 200; 8.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.189E-5 3.570E-3 3.123E-2
7.738E-2
 3 198
20 7319 UP Pentoxifylline [6493-05-6]; Up 200; 14.4uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.222E-5 3.570E-3 3.123E-2
7.855E-2
 3 199
21 7216 UP Repaglinide [135062-02-1]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.222E-5 3.570E-3 3.123E-2
7.855E-2
 3 199
22 3047 UP Nizatidine [76963-41-2]; Up 200; 12uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.222E-5 3.570E-3 3.123E-2
7.855E-2
 3 199
23 CID000002124 aluminum fluoride Stitch 5.399E-5 8.298E-3
7.259E-2
1.909E-1
 3 268
24 CID000002901 cycloleucine Stitch 1.870E-4 1.355E-2
1.185E-1
6.612E-1
 2 69
25 CID004488326 Tyr-D-Ala-Gly-N-methyl-Phe-Gly-ol Stitch 2.515E-4 1.355E-2
1.185E-1
8.891E-1
 2 80
26 CID000004253 morphine hydrochloride Stitch 3.050E-4 1.355E-2
1.185E-1
1.000E0
 3 481
27 CID010695334 SureCN1269469 Stitch 3.065E-4 1.355E-2
1.185E-1
1.000E0
 1 1
28 ctd:D012110 Reserpine CTD 5.557E-4 1.355E-2
1.185E-1
1.000E0
 2 119
29 CID005311249 NF062 Stitch 6.129E-4 1.355E-2
1.185E-1
1.000E0
 1 2
30 CID000005722 zaprinast Stitch 7.786E-4 1.355E-2
1.185E-1
1.000E0
 2 141
31 CID000001257 LY 171555 Stitch 7.896E-4 1.355E-2
1.185E-1
1.000E0
 2 142
32 ctd:D000661 Amphetamine CTD 8.688E-4 1.355E-2
1.185E-1
1.000E0
 2 149
33 1220 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.001E-3 1.355E-2
1.185E-1
1.000E0
 2 160
34 4444 UP SAHA; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.064E-3 1.355E-2
1.185E-1
1.000E0
 2 165
35 1234 UP Trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.089E-3 1.355E-2
1.185E-1
1.000E0
 2 167
36 1233 UP rosiglitazone; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.102E-3 1.355E-2
1.185E-1
1.000E0
 2 168
37 4018 UP Niclosamide [50-65-7]; Up 200; 12.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.102E-3 1.355E-2
1.185E-1
1.000E0
 2 168
38 CID000446755 P-NE Stitch 1.115E-3 1.355E-2
1.185E-1
1.000E0
 2 169
39 4632 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.115E-3 1.355E-2
1.185E-1
1.000E0
 2 169
40 1212 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.128E-3 1.355E-2
1.185E-1
1.000E0
 2 170
41 6736 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.128E-3 1.355E-2
1.185E-1
1.000E0
 2 170
42 4237 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.142E-3 1.355E-2
1.185E-1
1.000E0
 2 171
43 3791 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.142E-3 1.355E-2
1.185E-1
1.000E0
 2 171
44 7077 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.168E-3 1.355E-2
1.185E-1
1.000E0
 2 173
45 2105 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.168E-3 1.355E-2
1.185E-1
1.000E0
 2 173
46 2084 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.182E-3 1.355E-2
1.185E-1
1.000E0
 2 174
47 7073 UP trichostatin A, Streptomyces sp.; Up 200; 1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.195E-3 1.355E-2
1.185E-1
1.000E0
 2 175
48 4436 UP Trichostatin A, Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.195E-3 1.355E-2
1.185E-1
1.000E0
 2 175
49 7245 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.195E-3 1.355E-2
1.185E-1
1.000E0
 2 175
50 3746 UP Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.195E-3 1.355E-2
1.185E-1
1.000E0
 2 175
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 93 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C1858695 Chudley-McCullough syndrome Clinical Variations 4.320E-4 1.148E-2
5.870E-2
 4.017E-2 1 1
2 OMIN:613557 DEAFNESS, AUTOSOMAL RECESSIVE 82; DFNB82 OMIM 4.320E-4 1.148E-2
5.870E-2
 4.017E-2 1 1
3 cv:C1842073 Prolonged electroretinal response suppression Clinical Variations 8.638E-4 1.148E-2
5.870E-2
8.033E-2
 1 2
4 OMIN:604906 SCHIZOPHRENIA 9; SCZD9 OMIM 8.638E-4 1.148E-2
5.870E-2
8.033E-2
 1 2
5 C1842073 Prolonged Electroretinal Response Suppression DisGeNET Curated 8.638E-4 1.148E-2
5.870E-2
8.033E-2
 1 2
6 OMIN:608415 PROLONGED ELECTRORETINAL RESPONSE SUPPRESSION; PERRS OMIM 8.638E-4 1.148E-2
5.870E-2
8.033E-2
 1 2
7 C1997092 Hypertensive left ventricular hypertrophy DisGeNET BeFree 8.638E-4 1.148E-2
5.870E-2
8.033E-2
 1 2
8 C1858695 Chudley-Mccullough syndrome DisGeNET Curated 1.295E-3 1.506E-2
7.703E-2
1.205E-1
 1 3
9 C0431369 Dysgenesis of corpus callosum DisGeNET Curated 2.158E-3 1.720E-2
8.799E-2
2.007E-1
 1 5
10 C0266491 Neuronal heterotopia DisGeNET Curated 2.158E-3 1.720E-2
8.799E-2
2.007E-1
 1 5
11 C4280555 Increased circumference of foramen magnum DisGeNET Curated 2.589E-3 1.720E-2
8.799E-2
2.408E-1
 1 6
12 C4280554 Increased diameter of foramen magnum DisGeNET Curated 2.589E-3 1.720E-2
8.799E-2
2.408E-1
 1 6
13 C4073291 Hyperplasia of foramen magnum DisGeNET Curated 2.589E-3 1.720E-2
8.799E-2
2.408E-1
 1 6
14 C1844508 Large foramen magnum DisGeNET Curated 2.589E-3 1.720E-2
8.799E-2
2.408E-1
 1 6
15 C0752351 Embryo Loss DisGeNET Curated 3.020E-3 1.783E-2
9.121E-2
2.809E-1
 1 7
16 C3278322 Cerebellar dysplasia DisGeNET Curated 3.451E-3 1.783E-2
9.121E-2
3.210E-1
 1 8
17 C1959583 Myocardial Failure DisGeNET BeFree 3.451E-3 1.783E-2
9.121E-2
3.210E-1
 1 8
18 C0871099 positive and negative symptoms DisGeNET BeFree 3.451E-3 1.783E-2
9.121E-2
3.210E-1
 1 8
19 C1857278 Partial or complete agenesis of corpus callosum DisGeNET Curated 3.882E-3 1.900E-2
9.719E-2
3.610E-1
 1 9
20 C0431368 Partial agenesis of corpus callosum DisGeNET Curated 4.312E-3 1.910E-2
9.769E-2
4.011E-1
 1 10
21 C4021533 Severe sensorineural hearing impairment DisGeNET Curated 4.312E-3 1.910E-2
9.769E-2
4.011E-1
 1 10
22 C0392702 Abnormal involuntary movement DisGeNET BeFree 4.743E-3 2.005E-2
1.026E-1
4.411E-1
 1 11
23 C0078981 Arachnoid Cysts DisGeNET Curated 5.603E-3 2.171E-2
1.111E-1
5.211E-1
 1 13
24 C2063866 Depressive Disorder, Treatment-Resistant DisGeNET Curated 5.603E-3 2.171E-2
1.111E-1
5.211E-1
 1 13
25 C0033975 Psychotic Disorders DisGeNET Curated 7.234E-3 2.522E-2
1.290E-1
6.728E-1
 2 311
26 C0033941 Psychoses, Substance-Induced DisGeNET Curated 7.322E-3 2.522E-2
1.290E-1
6.809E-1
 1 17
27 C0013386 Dyskinesia, Drug-Induced DisGeNET Curated 7.322E-3 2.522E-2
1.290E-1
6.809E-1
 1 17
28 C0543968 Cone dysfunction syndrome DisGeNET BeFree 8.180E-3 2.717E-2
1.390E-1
7.607E-1
 1 19
29 C0158570 Vascular anomaly DisGeNET Curated 1.075E-2 3.448E-2
1.764E-1
9.999E-1
 1 25
30 C0546817 Fluid overload DisGeNET Curated 1.203E-2 3.718E-2
1.902E-1
1.000E0
 1 28
31 C0239849 Harlequin Fetus DisGeNET Curated 1.246E-2 3.718E-2
1.902E-1
1.000E0
 1 29
32 C0041696 Unipolar Depression DisGeNET Curated 1.279E-2 3.718E-2
1.902E-1
1.000E0
 2 418
33 C0392164 Pulmonary Cystic Fibrosis DisGeNET BeFree 1.630E-2 4.312E-2
2.206E-1
1.000E0
 1 38
34 C2732618 Sessile Serrated Adenoma/Polyp DisGeNET BeFree 1.630E-2 4.312E-2
2.206E-1
1.000E0
 1 38
35 C0152268 Hodgkin's disease, nodular sclerosis (clinical) DisGeNET BeFree 1.630E-2 4.312E-2
2.206E-1
1.000E0
 1 38
36 C2751492 AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED DisGeNET Curated 1.673E-2 4.312E-2
2.206E-1
1.000E0
 1 39
37 C0266449 Congenital anomaly of brain DisGeNET BeFree 1.715E-2 4.312E-2
2.206E-1
1.000E0
 1 40
38 C0162770 Right Ventricular Hypertrophy DisGeNET Curated 1.886E-2 4.470E-2
2.286E-1
1.000E0
 1 44
39 C0150055 Chronic pain DisGeNET Curated 1.971E-2 4.470E-2
2.286E-1
1.000E0
 1 46
40 C0856742 post mi DisGeNET BeFree 1.971E-2 4.470E-2
2.286E-1
1.000E0
 1 46
41 C0020428 Hyperaldosteronism DisGeNET Curated 1.971E-2 4.470E-2
2.286E-1
1.000E0
 1 46
42 C0686347 Tardive Dyskinesia DisGeNET BeFree 2.140E-2 4.614E-2
2.360E-1
1.000E0
 1 50
43 C3714760 Drug-induced tardive dyskinesia DisGeNET BeFree 2.140E-2 4.614E-2
2.360E-1
1.000E0
 1 50
44 C0751783 Lafora Disease DisGeNET Curated 2.183E-2 4.614E-2
2.360E-1
1.000E0
 1 51
45 C0022650 Kidney Calculi DisGeNET Curated 2.395E-2 4.949E-2
2.531E-1
1.000E0
 1 56
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