Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc169_12, positive side

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1: GO: Molecular Function [Display Chart] 12 input genes in category / 57 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0016941 natriuretic peptide receptor activity 2.032E-10 1.077E-8 4.985E-8 1.158E-8 3 3
2 GO:0004016 adenylate cyclase activity 3.779E-10 1.077E-8 4.985E-8 2.154E-8 4 19
3 GO:0016849 phosphorus-oxygen lyase activity 7.124E-10 1.229E-8 5.687E-8 4.061E-8 4 22
4 GO:0009975 cyclase activity 8.621E-10 1.229E-8 5.687E-8 4.914E-8 4 23
5 GO:0004383 guanylate cyclase activity 1.136E-8 1.295E-7 5.993E-7 6.473E-7 3 8
6 GO:0015280 ligand-gated sodium channel activity 1.703E-8 1.618E-7 7.488E-7 9.706E-7 3 9
7 GO:0050699 WW domain binding 1.096E-6 8.928E-6 4.133E-5 6.250E-5 3 33
8 GO:0005272 sodium channel activity 1.559E-6 1.111E-5 5.143E-5 8.888E-5 3 37
9 GO:0017046 peptide hormone binding 2.839E-6 1.798E-5 8.324E-5 1.618E-4 3 45
10 GO:0016829 lyase activity 5.360E-6 3.055E-5 1.414E-4 3.055E-4 4 195
11 GO:0019869 chloride channel inhibitor activity 1.361E-5 7.054E-5 3.265E-4 7.759E-4 2 9
12 GO:0042562 hormone binding 1.813E-5 8.613E-5 3.987E-4 1.034E-3 3 83
13 GO:0051428 peptide hormone receptor binding 5.128E-5 2.088E-4 9.664E-4 2.923E-3 2 17
14 GO:0017081 chloride channel regulator activity 5.128E-5 2.088E-4 9.664E-4 2.923E-3 2 17
15 GO:0001653 peptide receptor activity 7.766E-5 2.828E-4 1.309E-3 4.427E-3 3 135
16 GO:0015081 sodium ion transmembrane transporter activity 7.939E-5 2.828E-4 1.309E-3 4.525E-3 3 136
17 GO:0022834 ligand-gated channel activity 1.020E-4 3.232E-4 1.496E-3 5.817E-3 3 148
18 GO:0015276 ligand-gated ion channel activity 1.020E-4 3.232E-4 1.496E-3 5.817E-3 3 148
19 GO:0005184 neuropeptide hormone activity 1.979E-4 5.938E-4 2.749E-3 1.128E-2 2 33
20 GO:0008200 ion channel inhibitor activity 2.772E-4 7.900E-4 3.657E-3 1.580E-2 2 39
21 GO:0016248 channel inhibitor activity 3.065E-4 8.320E-4 3.852E-3 1.747E-2 2 41
22 GO:0042277 peptide binding 6.513E-4 1.688E-3 7.812E-3 3.713E-2 3 278
23 GO:0005261 cation channel activity 8.607E-4 2.103E-3 9.733E-3 4.906E-2 3 306
24 GO:0033218 amide binding 8.853E-4 2.103E-3 9.733E-3
5.046E-2
 3 309
25 GO:0022836 gated channel activity 1.080E-3 2.463E-3 1.140E-2
6.157E-2
 3 331
26 GO:0047805 cytidylate cyclase activity 1.286E-3 2.819E-3 1.305E-2
7.329E-2
 1 2
27 GO:0015077 monovalent inorganic cation transmembrane transporter activity 1.548E-3 3.223E-3 1.492E-2
8.821E-2
 3 375
28 GO:0005525 GTP binding 1.583E-3 3.223E-3 1.492E-2
9.025E-2
 3 378
29 GO:0032561 guanyl ribonucleotide binding 1.849E-3 3.538E-3 1.638E-2
1.054E-1
 3 399
30 GO:0019001 guanyl nucleotide binding 1.862E-3 3.538E-3 1.638E-2
1.061E-1
 3 400
31 GO:0005216 ion channel activity 2.199E-3 3.971E-3 1.838E-2
1.254E-1
 3 424
32 GO:0046873 metal ion transmembrane transporter activity 2.229E-3 3.971E-3 1.838E-2
1.271E-1
 3 426
33 GO:0022838 substrate-specific channel activity 2.413E-3 4.167E-3 1.929E-2
1.375E-1
 3 438
34 GO:0005179 hormone activity 2.768E-3 4.640E-3 2.148E-2
1.578E-1
 2 124
35 GO:0015267 channel activity 2.948E-3 4.696E-3 2.174E-2
1.680E-1
 3 470
36 GO:0022803 passive transmembrane transporter activity 2.966E-3 4.696E-3 2.174E-2
1.690E-1
 3 471
37 GO:0008528 G protein-coupled peptide receptor activity 3.129E-3 4.820E-3 2.231E-2
1.783E-1
 2 132
38 GO:0016247 channel regulator activity 3.462E-3 5.193E-3 2.404E-2
1.973E-1
 2 139
39 GO:0019870 potassium channel inhibitor activity 5.134E-3 7.503E-3 3.473E-2
2.926E-1
 1 8
40 GO:0051427 hormone receptor binding 5.918E-3 8.433E-3 3.903E-2
3.373E-1
 2 183
41 GO:0030291 protein serine/threonine kinase inhibitor activity 1.913E-2 2.659E-2
1.231E-1
1.000E0
 1 30
42 GO:0071855 neuropeptide receptor binding 1.976E-2 2.682E-2
1.241E-1
1.000E0
 1 31
43 GO:0051879 Hsp90 protein binding 2.291E-2 3.037E-2
1.406E-1
1.000E0
 1 36
44 GO:0015459 potassium channel regulator activity 3.044E-2 3.944E-2
1.826E-1
1.000E0
 1 48
45 GO:0004674 protein serine/threonine kinase activity 3.291E-2 4.168E-2
1.929E-1
1.000E0
 2 452
Show 40 more annotations

2: GO: Biological Process [Display Chart] 12 input genes in category / 362 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006182 cGMP biosynthetic process 8.477E-12 3.069E-9 1.985E-8 3.069E-9 5 32
2 GO:0007168 receptor guanylyl cyclase signaling pathway 3.253E-11 5.887E-9 3.809E-8 1.177E-8 4 11
3 GO:0046068 cGMP metabolic process 9.829E-11 1.186E-8 7.674E-8 3.558E-8 5 51
4 GO:0052652 cyclic purine nucleotide metabolic process 2.781E-10 2.093E-8 1.354E-7 1.007E-7 6 156
5 GO:0009190 cyclic nucleotide biosynthetic process 2.890E-10 2.093E-8 1.354E-7 1.046E-7 6 157
6 GO:0009187 cyclic nucleotide metabolic process 1.489E-9 8.984E-8 5.813E-7 5.391E-7 6 206
7 GO:0009152 purine ribonucleotide biosynthetic process 5.360E-9 2.653E-7 1.717E-6 1.940E-6 6 255
8 GO:0006164 purine nucleotide biosynthetic process 6.161E-9 2.653E-7 1.717E-6 2.230E-6 6 261
9 GO:0009260 ribonucleotide biosynthetic process 7.219E-9 2.653E-7 1.717E-6 2.613E-6 6 268
10 GO:0046390 ribose phosphate biosynthetic process 7.887E-9 2.653E-7 1.717E-6 2.855E-6 6 272
11 GO:0072522 purine-containing compound biosynthetic process 8.062E-9 2.653E-7 1.717E-6 2.919E-6 6 273
12 GO:0009165 nucleotide biosynthetic process 2.120E-8 6.239E-7 4.037E-6 7.674E-6 6 321
13 GO:1901293 nucleoside phosphate biosynthetic process 2.241E-8 6.239E-7 4.037E-6 8.111E-6 6 324
14 GO:0055078 sodium ion homeostasis 3.832E-8 9.909E-7 6.411E-6 1.387E-5 4 57
15 GO:0050891 multicellular organismal water homeostasis 6.970E-8 1.677E-6 1.085E-5 2.523E-5 4 66
16 GO:1903779 regulation of cardiac conduction 7.410E-8 1.677E-6 1.085E-5 2.683E-5 4 67
17 GO:0008217 regulation of blood pressure 9.389E-8 1.999E-6 1.294E-5 3.399E-5 5 197
18 GO:0030157 pancreatic juice secretion 1.383E-7 2.756E-6 1.783E-5 5.006E-5 3 17
19 GO:0030104 water homeostasis 1.447E-7 2.756E-6 1.783E-5 5.237E-5 4 79
20 GO:0006814 sodium ion transport 1.555E-7 2.815E-6 1.822E-5 5.630E-5 5 218
21 GO:0007589 body fluid secretion 4.561E-7 7.863E-6 5.088E-5 1.651E-4 4 105
22 GO:0061337 cardiac conduction 1.108E-6 1.798E-5 1.163E-4 4.011E-4 4 131
23 GO:0035725 sodium ion transmembrane transport 1.142E-6 1.798E-5 1.163E-4 4.135E-4 4 132
24 GO:1900194 negative regulation of oocyte maturation 2.282E-6 3.391E-5 2.194E-4 8.261E-4 2 4
25 GO:0055067 monovalent inorganic cation homeostasis 2.342E-6 3.391E-5 2.194E-4 8.477E-4 4 158
26 GO:0060283 negative regulation of oocyte development 3.802E-6 5.294E-5 3.425E-4 1.376E-3 2 5
27 GO:0035637 multicellular organismal signaling 5.626E-6 7.371E-5 4.769E-4 2.037E-3 4 197
28 GO:0090188 negative regulation of pancreatic juice secretion 5.701E-6 7.371E-5 4.769E-4 2.064E-3 2 6
29 GO:1900193 regulation of oocyte maturation 7.979E-6 9.960E-5 6.444E-4 2.888E-3 2 7
30 GO:0050909 sensory perception of taste 9.567E-6 1.154E-4 7.470E-4 3.463E-3 3 67
31 GO:1903430 negative regulation of cell maturation 1.063E-5 1.242E-4 8.035E-4 3.850E-3 2 8
32 GO:0008016 regulation of heart contraction 1.269E-5 1.435E-4 9.285E-4 4.592E-3 4 242
33 GO:0032414 positive regulation of ion transmembrane transporter activity 1.572E-5 1.717E-4 1.111E-3 5.692E-3 3 79
34 GO:0007588 excretion 1.633E-5 1.717E-4 1.111E-3 5.912E-3 3 80
35 GO:0060281 regulation of oocyte development 1.708E-5 1.717E-4 1.111E-3 6.183E-3 2 10
36 GO:0090186 regulation of pancreatic juice secretion 1.708E-5 1.717E-4 1.111E-3 6.183E-3 2 10
37 GO:0060047 heart contraction 2.128E-5 2.082E-4 1.347E-3 7.702E-3 4 276
38 GO:0003015 heart process 2.220E-5 2.088E-4 1.351E-3 8.036E-3 4 279
39 GO:0032411 positive regulation of transporter activity 2.250E-5 2.088E-4 1.351E-3 8.145E-3 3 89
40 GO:0032941 secretion by tissue 2.736E-5 2.476E-4 1.602E-3 9.906E-3 3 95
41 GO:0022600 digestive system process 3.486E-5 3.078E-4 1.992E-3 1.262E-2 3 103
42 GO:1903522 regulation of blood circulation 4.489E-5 3.826E-4 2.475E-3 1.625E-2 4 334
43 GO:0035810 positive regulation of urine volume 4.545E-5 3.826E-4 2.475E-3 1.645E-2 2 16
44 GO:0060457 negative regulation of digestive system process 5.149E-5 4.236E-4 2.741E-3 1.864E-2 2 17
45 GO:0035313 wound healing, spreading of epidermal cells 5.790E-5 4.658E-4 3.014E-3 2.096E-2 2 18
46 GO:0003014 renal system process 6.214E-5 4.890E-4 3.164E-3 2.249E-2 3 125
47 GO:0051447 negative regulation of meiotic cell cycle 6.469E-5 4.983E-4 3.224E-3 2.342E-2 2 19
48 GO:0048660 regulation of smooth muscle cell proliferation 6.825E-5 5.147E-4 3.330E-3 2.471E-2 3 129
49 GO:0048871 multicellular organismal homeostasis 7.268E-5 5.370E-4 3.474E-3 2.631E-2 4 378
50 GO:0048659 smooth muscle cell proliferation 7.474E-5 5.411E-4 3.501E-3 2.706E-2 3 133
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 12 input genes in category / 29 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008074 guanylate cyclase complex, soluble 1.066E-8 3.090E-7 1.224E-6 3.090E-7 3 8
2 GO:0034706 sodium channel complex 1.290E-7 1.870E-6 7.410E-6 3.741E-6 3 17
3 GO:0034703 cation channel complex 1.601E-4 1.548E-3 6.133E-3 4.644E-3 3 176
4 GO:0044445 cytosolic part 3.749E-4 2.718E-3 1.077E-2 1.087E-2 3 235
5 GO:0034702 ion channel complex 6.996E-4 3.390E-3 1.343E-2 2.029E-2 3 291
6 GO:0009897 external side of plasma membrane 8.406E-4 3.390E-3 1.343E-2 2.438E-2 3 310
7 GO:1902495 transmembrane transporter complex 9.811E-4 3.390E-3 1.343E-2 2.845E-2 3 327
8 GO:1990351 transporter complex 1.034E-3 3.390E-3 1.343E-2 2.999E-2 3 333
9 GO:0016324 apical plasma membrane 1.052E-3 3.390E-3 1.343E-2 3.051E-2 3 335
10 GO:0045177 apical part of cell 2.127E-3 6.167E-3 2.443E-2
6.167E-2
 3 428
11 GO:0042629 mast cell granule 1.439E-2 3.793E-2
1.503E-1
4.173E-1
 1 23
Show 6 more annotations

4: Human Phenotype [Display Chart] 7 input genes in category / 252 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0008242 Pseudohypoaldosteronism 6.114E-14 1.541E-11 9.412E-11 1.541E-11 5 8
2 HP:0002153 Hyperkalemia 1.840E-10 2.318E-8 1.416E-7 4.637E-8 5 31
3 HP:0011422 Abnormality of chloride homeostasis 5.317E-8 4.466E-6 2.728E-5 1.340E-5 4 31
4 HP:0011042 Abnormality of potassium homeostasis 7.559E-8 4.762E-6 2.909E-5 1.905E-5 5 99
5 HP:0000841 Hyperactive renin-angiotensin system 1.686E-7 8.498E-6 5.191E-5 4.249E-5 3 9
6 HP:0010930 Abnormality of monovalent inorganic cation homeostasis 1.115E-6 4.683E-5 2.861E-4 2.810E-4 5 169
7 HP:0011733 Abnormality of adrenal physiology 5.062E-6 1.822E-4 1.113E-3 1.276E-3 5 229
8 HP:0000847 Abnormality of renin-angiotensin system 9.811E-6 3.090E-4 1.888E-3 2.472E-3 3 32
9 HP:0004469 Chronic bronchitis 1.409E-5 3.550E-4 2.168E-3 3.550E-3 3 36
10 HP:0000127 Renal salt wasting 1.409E-5 3.550E-4 2.168E-3 3.550E-3 3 36
11 HP:0011423 Hyperchloremia 1.892E-5 4.334E-4 2.648E-3 4.768E-3 2 5
12 HP:0000834 Abnormality of the adrenal glands 2.406E-5 5.053E-4 3.086E-3 6.063E-3 5 314
13 HP:0010929 Abnormality of cation homeostasis 3.454E-5 6.056E-4 3.699E-3 8.704E-3 5 338
14 HP:0000859 Hyperaldosteronism 3.605E-5 6.056E-4 3.699E-3 9.084E-3 3 49
15 HP:0002855 Abnormality of aldosterone production 3.605E-5 6.056E-4 3.699E-3 9.084E-3 3 49
16 HP:0003111 Abnormality of ion homeostasis 5.100E-5 7.836E-4 4.787E-3 1.285E-2 5 366
17 HP:0004918 Hyperchloremic metabolic acidosis 5.286E-5 7.836E-4 4.787E-3 1.332E-2 2 8
18 HP:0001995 Hyperchloremic acidosis 6.792E-5 9.509E-4 5.809E-3 1.712E-2 2 9
19 HP:0001942 Metabolic acidosis 9.249E-5 1.167E-3 7.131E-3 2.331E-2 4 196
20 HP:0002717 Adrenal overactivity 9.265E-5 1.167E-3 7.131E-3 2.335E-2 3 67
21 HP:0003351 Decreased circulating renin level 1.243E-4 1.491E-3 9.108E-3 3.131E-2 2 12
22 HP:0001949 Hypokalemic alkalosis 1.467E-4 1.608E-3 9.821E-3 3.698E-2 2 13
23 HP:0011736 Primary hyperaldosteronism 1.467E-4 1.608E-3 9.821E-3 3.698E-2 2 13
24 HP:0001941 Acidosis 1.812E-4 1.903E-3 1.163E-2 4.567E-2 5 475
25 HP:0002924 Decreased circulating aldosterone level 2.253E-4 2.271E-3 1.387E-2
5.677E-2
 2 16
26 HP:0040085 Abnormal circulating aldosterone 2.551E-4 2.409E-3 1.472E-2
6.429E-2
 2 17
27 HP:0012387 Bronchitis 2.712E-4 2.409E-3 1.472E-2
6.835E-2
 3 96
28 HP:0000849 Adrenocortical abnormality 2.712E-4 2.409E-3 1.472E-2
6.835E-2
 3 96
29 HP:0040127 Abnormal sweat homeostasis 2.868E-4 2.409E-3 1.472E-2
7.228E-2
 2 18
30 HP:0012236 Elevated sweat chloride 2.868E-4 2.409E-3 1.472E-2
7.228E-2
 2 18
31 HP:0002902 Hyponatremia 4.060E-4 3.300E-3 2.016E-2
1.023E-1
 3 110
32 HP:0003350 Abnormality of the renin-aldosterone axis 4.318E-4 3.401E-3 2.077E-2
1.088E-1
 2 22
33 HP:0040084 Abnormal circulating renin 5.152E-4 3.934E-3 2.403E-2
1.298E-1
 2 24
34 HP:0010931 Abnormality of sodium homeostasis 5.645E-4 4.184E-3 2.556E-2
1.423E-1
 3 123
35 HP:0008872 Feeding difficulties in infancy 9.173E-4 6.536E-3 3.993E-2
2.312E-1
 4 354
36 HP:0012591 Abnormal urinary electrolyte concentration 9.337E-4 6.536E-3 3.993E-2
2.353E-1
 3 146
37 HP:0002788 Recurrent upper respiratory tract infections 1.406E-3 9.141E-3
5.584E-2
3.544E-1
 3 168
38 HP:0001944 Dehydration 1.480E-3 9.141E-3
5.584E-2
3.731E-1
 3 171
39 HP:0008484 Thoracolumbar interpediculate narrowness 1.487E-3 9.141E-3
5.584E-2
3.748E-1
 1 1
40 HP:0004633 Lower thoracic kyphosis 1.487E-3 9.141E-3
5.584E-2
3.748E-1
 1 1
41 HP:0007516 Redundant skin on fingers 1.487E-3 9.141E-3
5.584E-2
3.748E-1
 1 1
42 HP:0002110 Bronchiectasis 1.802E-3 1.081E-2
6.606E-2
4.542E-1
 3 183
43 HP:0001739 Abnormality of the nasopharynx 1.949E-3 1.142E-2
6.976E-2
4.911E-1
 3 188
44 HP:0011732 Abnormality of adrenal morphology 2.682E-3 1.536E-2
9.383E-2
6.758E-1
 3 210
45 HP:0025426 Abnormal bronchus morphology 2.870E-3 1.607E-2
9.816E-2
7.231E-1
 3 215
46 HP:0002109 Abnormality of the bronchi 2.986E-3 1.636E-2
9.993E-2
7.525E-1
 3 218
47 HP:0000600 Abnormality of the pharynx 3.228E-3 1.731E-2
1.057E-1
8.134E-1
 3 224
48 HP:0002615 Hypotension 4.268E-3 2.241E-2
1.369E-1
1.000E0
 3 247
49 HP:0002900 Hypokalemia 5.260E-3 2.705E-2
1.652E-1
1.000E0
 2 77
50 HP:0001948 Alkalosis 5.668E-3 2.857E-2
1.745E-1
1.000E0
 2 80
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 12 input genes in category / 519 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011415 abnormal aldosterone level 1.486E-9 7.714E-7 5.269E-6 7.714E-7 5 49
2 MP:0000230 abnormal systemic arterial blood pressure 4.022E-9 1.044E-6 7.128E-6 2.087E-6 7 259
3 MP:0000231 hypertension 8.661E-9 1.324E-6 9.046E-6 4.495E-6 5 69
4 MP:0002842 increased systemic arterial blood pressure 1.060E-8 1.324E-6 9.046E-6 5.504E-6 6 160
5 MP:0011977 abnormal sodium ion homeostasis 1.276E-8 1.324E-6 9.046E-6 6.622E-6 6 165
6 MP:0003372 abnormal circulating mineralocorticoid level 1.245E-7 9.234E-6 6.307E-5 6.464E-5 4 43
7 MP:0005346 abnormal circulating aldosterone level 1.245E-7 9.234E-6 6.307E-5 6.464E-5 4 43
8 MP:0004043 abnormal pH regulation 2.314E-7 1.501E-5 1.025E-4 1.201E-4 4 50
9 MP:0005627 increased circulating potassium level 3.170E-7 1.828E-5 1.249E-4 1.645E-4 4 54
10 MP:0006274 abnormal urine sodium level 5.937E-7 3.082E-5 2.105E-4 3.082E-4 4 63
11 MP:0006144 increased systemic arterial systolic blood pressure 1.203E-6 5.674E-5 3.875E-4 6.241E-4 4 75
12 MP:0005634 decreased circulating sodium level 2.696E-6 1.166E-4 7.964E-4 1.399E-3 3 25
13 MP:0002666 increased circulating aldosterone level 3.424E-6 1.269E-4 8.670E-4 1.777E-3 3 27
14 MP:0003373 increased circulating mineralocorticoid level 3.424E-6 1.269E-4 8.670E-4 1.777E-3 3 27
15 MP:0002668 abnormal circulating potassium level 3.820E-6 1.322E-4 9.027E-4 1.982E-3 4 100
16 MP:0006316 increased urine sodium level 5.249E-6 1.703E-4 1.163E-3 2.724E-3 3 31
17 MP:0001776 abnormal circulating sodium level 5.589E-6 1.706E-4 1.165E-3 2.901E-3 4 110
18 MP:0009643 abnormal urine homeostasis 6.351E-6 1.738E-4 1.187E-3 3.296E-3 6 472
19 MP:0003031 acidosis 6.362E-6 1.738E-4 1.187E-3 3.302E-3 3 33
20 MP:0014204 abnormal intestinal epithelial sodium ion transmembrane transport 7.377E-6 1.740E-4 1.189E-3 3.829E-3 2 4
21 MP:0014206 decreased intestinal epithelial sodium ion transmembrane transport 7.377E-6 1.740E-4 1.189E-3 3.829E-3 2 4
22 MP:0011461 abnormal urine bicarbonate level 7.377E-6 1.740E-4 1.189E-3 3.829E-3 2 4
23 MP:0002843 decreased systemic arterial blood pressure 7.903E-6 1.783E-4 1.218E-3 4.102E-3 4 120
24 MP:0011978 abnormal potassium ion homeostasis 1.120E-5 2.421E-4 1.654E-3 5.810E-3 4 131
25 MP:0006143 increased systemic arterial diastolic blood pressure 1.430E-5 2.968E-4 2.027E-3 7.420E-3 3 43
26 MP:0014202 abnormal intestinal epithelial transmembrane transport 1.842E-5 3.414E-4 2.332E-3 9.560E-3 2 6
27 MP:0006394 abnormal vertebral epiphyseal plate morphology 1.842E-5 3.414E-4 2.332E-3 9.560E-3 2 6
28 MP:0010109 abnormal renal sodium reabsorbtion 1.842E-5 3.414E-4 2.332E-3 9.560E-3 2 6
29 MP:0001756 abnormal urination 2.719E-5 4.867E-4 3.324E-3 1.411E-2 4 164
30 MP:0003028 alkalosis 3.434E-5 5.941E-4 4.058E-3 1.782E-2 2 8
31 MP:0011442 abnormal renal sodium ion transport 5.512E-5 8.668E-4 5.921E-3 2.861E-2 2 10
32 MP:0004217 salt-sensitive hypertension 5.512E-5 8.668E-4 5.921E-3 2.861E-2 2 10
33 MP:0006272 abnormal urine organic anion level 5.512E-5 8.668E-4 5.921E-3 2.861E-2 2 10
34 MP:0003662 abnormal long bone epiphyseal plate proliferative zone 9.291E-5 1.418E-3 9.687E-3 4.822E-2 3 80
35 MP:0004119 hypokalemia 1.112E-4 1.603E-3 1.095E-2
5.770E-2
 2 14
36 MP:0001599 abnormal blood volume 1.112E-4 1.603E-3 1.095E-2
5.770E-2
 2 14
37 MP:0003018 abnormal circulating chloride level 1.277E-4 1.791E-3 1.223E-2
6.626E-2
 3 89
38 MP:0012551 metabolic acidosis 1.658E-4 2.265E-3 1.547E-2
8.606E-2
 2 17
39 MP:0003374 decreased circulating mineralocorticoid level 1.864E-4 2.419E-3 1.652E-2
9.676E-2
 2 18
40 MP:0002667 decreased circulating aldosterone level 1.864E-4 2.419E-3 1.652E-2
9.676E-2
 2 18
41 MP:0005618 decreased urine potassium level 2.082E-4 2.636E-3 1.800E-2
1.081E-1
 2 19
42 MP:0012007 abnormal chloride level 2.458E-4 3.037E-3 2.075E-2
1.276E-1
 3 111
43 MP:0011999 abnormal tail length 2.729E-4 3.294E-3 2.250E-2
1.416E-1
 3 115
44 MP:0011417 abnormal renal transport 3.639E-4 4.293E-3 2.932E-2
1.889E-1
 2 25
45 MP:0003620 oliguria 4.252E-4 4.904E-3 3.350E-2
2.207E-1
 2 27
46 MP:0003349 abnormal circulating renin level 4.912E-4 5.542E-3 3.786E-2
2.550E-1
 2 29
47 MP:0001596 hypotension 5.260E-4 5.808E-3 3.967E-2
2.730E-1
 2 30
48 MP:0000165 abnormal long bone hypertrophic chondrocyte zone 5.726E-4 6.191E-3 4.229E-2
2.972E-1
 3 148
49 MP:0006397 disorganized long bone epiphyseal plate 7.171E-4 7.596E-3
5.188E-2
3.722E-1
 2 35
50 MP:0004820 abnormal urine potassium level 1.033E-3 1.055E-2
7.207E-2
5.362E-1
 2 42
Show 45 more annotations

6: Domain [Display Chart] 12 input genes in category / 46 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00458 ANF RECEPTORS PROSITE 2.008E-10 4.618E-9 2.039E-8 9.235E-9 3 3
2 IPR001170 ANPR/GUC InterPro 2.008E-10 4.618E-9 2.039E-8 9.235E-9 3 3
3 IPR004724 ENaC InterPro 7.017E-9 1.076E-7 4.752E-7 3.228E-7 3 7
4 IPR020903 Na+channel ASC CS InterPro 1.122E-8 1.106E-7 4.884E-7 5.162E-7 3 8
5 PF00858 ASC Pfam 1.683E-8 1.106E-7 4.884E-7 7.741E-7 3 9
6 IPR001873 Na+channel ASC InterPro 1.683E-8 1.106E-7 4.884E-7 7.741E-7 3 9
7 PS01206 ASC PROSITE 1.683E-8 1.106E-7 4.884E-7 7.741E-7 3 9
8 IPR018297 A/G cyclase CS InterPro 1.358E-7 5.932E-7 2.620E-6 6.248E-6 3 17
9 3.30.70.1230 - Gene3D 1.629E-7 5.932E-7 2.620E-6 7.495E-6 3 18
10 IPR029787 Nucleotide cyclase InterPro 1.629E-7 5.932E-7 2.620E-6 7.495E-6 3 18
11 PS00452 GUANYLATE CYCLASE 1 PROSITE 1.934E-7 5.932E-7 2.620E-6 8.897E-6 3 19
12 IPR001054 A/G cyclase InterPro 1.934E-7 5.932E-7 2.620E-6 8.897E-6 3 19
13 PF00211 Guanylate cyc Pfam 1.934E-7 5.932E-7 2.620E-6 8.897E-6 3 19
14 PS50125 GUANYLATE CYCLASE 2 PROSITE 1.934E-7 5.932E-7 2.620E-6 8.897E-6 3 19
15 SM00044 CYCc SMART 1.934E-7 5.932E-7 2.620E-6 8.897E-6 3 19
16 PS00263 NATRIURETIC PEPTIDE PROSITE 1.128E-6 2.594E-6 1.146E-5 5.188E-5 2 3
17 IPR000663 Natr peptide InterPro 1.128E-6 2.594E-6 1.146E-5 5.188E-5 2 3
18 SM00183 NAT PEP SMART 1.128E-6 2.594E-6 1.146E-5 5.188E-5 2 3
19 PF00212 ANP Pfam 1.128E-6 2.594E-6 1.146E-5 5.188E-5 2 3
20 IPR030480 Natr peptide CS InterPro 1.128E-6 2.594E-6 1.146E-5 5.188E-5 2 3
21 PF01094 ANF receptor Pfam 1.541E-6 3.222E-6 1.423E-5 7.088E-5 3 37
22 IPR001828 ANF lig-bd rcpt InterPro 1.541E-6 3.222E-6 1.423E-5 7.088E-5 3 37
23 IPR028082 Peripla BP I InterPro 1.811E-6 3.622E-6 1.600E-5 8.331E-5 3 39
24 PF12202 OSR1 C Pfam 5.633E-6 1.037E-5 4.578E-5 2.591E-4 2 6
25 IPR024678 Kinase OSR1/WNK CCT InterPro 5.633E-6 1.037E-5 4.578E-5 2.591E-4 2 6
26 IPR000719 Prot kinase dom InterPro 1.921E-4 3.377E-4 1.491E-3 8.836E-3 4 489
27 PS50011 PROTEIN KINASE DOM PROSITE 1.982E-4 3.377E-4 1.491E-3 9.117E-3 4 493
28 IPR002406 C natriurtcpep InterPro 6.405E-4 9.821E-4 4.338E-3 2.946E-2 1 1
29 IPR002407 Natriuretic peptide atrial InterPro 6.405E-4 9.821E-4 4.338E-3 2.946E-2 1 1
30 IPR032953 BPIFA1/Latherin InterPro 6.405E-4 9.821E-4 4.338E-3 2.946E-2 1 1
31 PF00069 Pkinase Pfam 1.601E-3 2.376E-3 1.050E-2
7.367E-2
 3 381
32 PF07700 HNOB Pfam 2.560E-3 3.680E-3 1.625E-2
1.178E-1
 1 4
33 PF07714 Pkinase Tyr Pfam 2.968E-3 4.137E-3 1.827E-2
1.365E-1
 2 129
34 IPR001245 Ser-Thr/Tyr kinase cat dom InterPro 3.387E-3 4.583E-3 2.024E-2
1.558E-1
 2 138
35 IPR011645 HNOB dom associated InterPro 3.837E-3 4.903E-3 2.166E-2
1.765E-1
 1 6
36 PF07701 HNOBA Pfam 3.837E-3 4.903E-3 2.166E-2
1.765E-1
 1 6
37 IPR024096 NO sig/Golgi transp ligand-bd InterPro 5.114E-3 6.357E-3 2.808E-2
2.352E-1
 1 8
38 IPR011644 Heme NO-bd InterPro 5.751E-3 6.962E-3 3.075E-2
2.646E-1
 1 9
39 IPR032942 BPI/LBP/Plunc InterPro 8.297E-3 9.088E-3 4.014E-2
3.817E-1
 1 13
40 IPR017943 Bactericidal perm-incr a/b dom InterPro 8.297E-3 9.088E-3 4.014E-2
3.817E-1
 1 13
41 PF01273 LBP BPI CETP Pfam 8.297E-3 9.088E-3 4.014E-2
3.817E-1
 1 13
42 IPR017942 Lipid-bd serum glycop N InterPro 8.297E-3 9.088E-3 4.014E-2
3.817E-1
 1 13
43 IPR008271 Ser/Thr kinase AS InterPro 2.106E-2 2.210E-2
9.762E-2
9.690E-1
 2 357
44 SM00220 S TKc SMART 2.129E-2 2.210E-2
9.762E-2
9.792E-1
 2 359
45 PS00108 PROTEIN KINASE ST PROSITE 2.162E-2 2.210E-2
9.762E-2
9.946E-1
 2 362
46 PS00107 PROTEIN KINASE ATP PROSITE 3.360E-2 3.360E-2
1.484E-1
1.000E0
 2 459
Show 41 more annotations

7: Pathway [Display Chart] 12 input genes in category / 54 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1339122 Physiological factors BioSystems: REACTOME 2.439E-10 1.317E-8 6.025E-8 1.317E-8 4 12
2 PW:0000473 C-type natriuretic peptide signaling Pathway Ontology 6.842E-10 1.847E-8 8.452E-8 3.695E-8 3 3
3 1269953 Stimuli-sensing channels BioSystems: REACTOME 2.791E-8 5.024E-7 2.299E-6 1.507E-6 5 104
4 1269950 Ion channel transport BioSystems: REACTOME 9.147E-7 1.235E-5 5.650E-5 4.939E-5 5 209
5 PW:0000471 atrial natriuretic peptide signaling Pathway Ontology 2.554E-6 2.758E-5 1.262E-4 1.379E-4 2 3
6 130626 Aldosterone-regulated sodium reabsorption BioSystems: KEGG 5.219E-6 4.697E-5 2.149E-4 2.818E-4 3 37
7 1339115 Cardiac conduction BioSystems: REACTOME 7.479E-6 5.577E-5 2.552E-4 4.039E-4 4 142
8 PW:0000031 purine metabolic Pathway Ontology 8.262E-6 5.577E-5 2.552E-4 4.462E-4 3 43
9 1269868 Muscle contraction BioSystems: REACTOME 3.126E-5 1.875E-4 8.581E-4 1.688E-3 4 204
10 83088 Taste transduction BioSystems: KEGG 6.019E-5 2.743E-4 1.255E-3 3.250E-3 3 83
11 MAP00230 Purine metabolism MAP00230 Purine metabolism GenMAPP 6.239E-5 2.743E-4 1.255E-3 3.369E-3 3 84
12 SMP00135 Eplerenone Pathway SMPDB 6.604E-5 2.743E-4 1.255E-3 3.566E-3 2 13
13 SMP00134 Spironolactone Pathway SMPDB 6.604E-5 2.743E-4 1.255E-3 3.566E-3 2 13
14 SMP00133 Amiloride Pathway SMPDB 7.701E-5 2.772E-4 1.268E-3 4.158E-3 2 14
15 SMP00132 Triamterene Pathway SMPDB 7.701E-5 2.772E-4 1.268E-3 4.158E-3 2 14
16 96530 Vascular smooth muscle contraction BioSystems: KEGG 1.848E-4 6.237E-4 2.854E-3 9.979E-3 3 121
17 952859 Oxytocin signaling pathway BioSystems: KEGG 3.691E-4 8.181E-4 3.743E-3 1.993E-2 3 153
18 983748 cGMP-PKG signaling pathway BioSystems: KEGG 4.444E-4 8.181E-4 3.743E-3 2.400E-2 3 163
19 SMP00155 Rescinnamine Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
20 SMP00154 Ramipril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
21 SMP00146 Captopril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
22 SMP00157 Trandolapril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
23 SMP00152 Perindopril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
24 SMP00153 Quinapril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
25 SMP00145 Benazepril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
26 SMP00148 Enalapril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
27 SMP00147 Cilazapril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
28 SMP00156 Spirapril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
29 SMP00149 Fosinopril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
30 SMP00150 Lisinopril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
31 SMP00151 Moexipril Pathway SMPDB 4.697E-4 8.181E-4 3.743E-3 2.536E-2 2 34
32 82944 Purine metabolism BioSystems: KEGG 5.471E-4 9.232E-4 4.224E-3 2.954E-2 3 175
33 1222951 Renin secretion BioSystems: KEGG 1.713E-3 2.803E-3 1.282E-2
9.249E-2
 2 65
34 PW:0000472 brain natriuretic peptide signaling Pathway Ontology 1.927E-3 3.060E-3 1.400E-2
1.041E-1
 1 2
35 PW:0000603 Erk5 MAPK signaling Pathway Ontology 5.770E-3 8.903E-3 4.073E-2
3.116E-1
 1 6
36 M10066 Corticosteroids and cardioprotection MSigDB C2 BIOCARTA (v6.0) 1.912E-2 2.867E-2
1.312E-1
1.000E0
 1 20
37 1269343 Nitric oxide stimulates guanylate cyclase BioSystems: REACTOME 2.290E-2 3.342E-2
1.529E-1
1.000E0
 1 24
38 SMP00050 Purine Metabolism SMPDB 2.573E-2 3.656E-2
1.673E-1
1.000E0
 1 27
39 1269653 YAP1- and WWTR1 (TAZ)-stimulated gene expression BioSystems: REACTOME 2.761E-2 3.823E-2
1.749E-1
1.000E0
 1 29
40 M17400 ALK in cardiac myocytes MSigDB C2 BIOCARTA (v6.0) 3.510E-2 4.739E-2
2.168E-1
1.000E0
 1 37
Show 35 more annotations

8: Pubmed [Display Chart] 12 input genes in category / 1983 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 15196958 Embryonic expression and multifunctional actions of the natriuretic peptides and receptors in the developing nervous system. Pubmed 1.170E-18 2.319E-15 1.895E-14 2.320E-15 5 5
2 20700369 Characterization and functional expression of the natriuretic peptide system in human lens epithelial cells. Pubmed 7.018E-18 2.319E-15 1.895E-14 1.392E-14 5 6
3 1660465 Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera. Pubmed 7.018E-18 2.319E-15 1.895E-14 1.392E-14 5 6
4 19805191 Regulation of axonal development by natriuretic peptide hormones. Pubmed 7.018E-18 2.319E-15 1.895E-14 1.392E-14 5 6
5 1309330 Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Pubmed 7.018E-18 2.319E-15 1.895E-14 1.392E-14 5 6
6 1672777 Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP). Pubmed 7.018E-18 2.319E-15 1.895E-14 1.392E-14 5 6
7 19326473 Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting. Pubmed 2.456E-17 6.957E-15 5.684E-14 4.870E-14 5 7
8 19458086 A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation. Pubmed 5.584E-15 1.107E-12 9.047E-12 1.107E-11 4 4
9 24124190 Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial cultures. Pubmed 5.584E-15 1.107E-12 9.047E-12 1.107E-11 4 4
10 20519934 SPLUNC1 expression reduces surface levels of the epithelial sodium channel (ENaC) in Xenopus laevis oocytes. Pubmed 5.584E-15 1.107E-12 9.047E-12 1.107E-11 4 4
11 23594824 WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination. Pubmed 2.792E-14 4.613E-12 3.769E-11 5.536E-11 4 5
12 16870210 Structural determinants of natriuretic peptide receptor specificity and degeneracy. Pubmed 2.792E-14 4.613E-12 3.769E-11 5.536E-11 4 5
13 19805384 C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Pubmed 1.841E-12 2.808E-10 2.294E-9 3.650E-9 4 11
14 23684652 Genetic dissection of sodium and potassium transport along the aldosterone-sensitive distal nephron: importance in the control of blood pressure and hypertension. Pubmed 2.760E-12 3.910E-10 3.194E-9 5.474E-9 4 12
15 20024606 Evidence for cross-talk between atrial natriuretic peptide and nitric oxide receptors. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
16 23218889 Expression of the epithelial sodium channel sensitive to amiloride (ENaC) in normal and preeclamptic human placenta. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
17 17766193 Upregulated expression of ENaC in human CF nasal epithelium. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
18 22207244 Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
19 9990093 Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
20 19300301 Functional and molecular expression of epithelial sodium channels in cultured human endolymphatic sac epithelial cells. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
21 8986818 Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
22 25559464 Expression and distribution of epithelial sodium channel in nasal polyp and nasal mucosa. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
23 17522058 Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
24 20504903 Interleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cells. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
25 17199078 Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
26 29358325 Mapping allosteric linkage to channel gating by extracellular domains in the human epithelial sodium channel. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
27 10404817 Polymorphisms of amiloride-sensitive sodium channel subunits in five sporadic cases of pseudohypoaldosteronism: do they have pathologic potential? Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
28 12897071 A region directly following the second transmembrane domain in gamma ENaC is required for normal channel gating. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
29 27903760 Interactions between intersubunit transmembrane domains regulate the chaperone-dependent degradation of an oligomeric membrane protein. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
30 12770839 Multiple epithelial Na+ channel domains participate in subunit assembly. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
31 12576470 Asymmetric organization of the pore region of the epithelial sodium channel. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
32 18990692 Extracellular protons regulate human ENaC by modulating Na+ self-inhibition. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
33 20106988 Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
34 19158091 Novel determinants of epithelial sodium channel gating within extracellular thumb domains. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
35 25860030 Increased Bone Turnover and Possible Accelerated Fracture Healing in a Murine Model With an Increased Circulating C-Type Natriuretic Peptide. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
36 12876281 Regulation of the epithelial Na+ channel by cytosolic ATP. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
37 19462466 Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
38 15166222 Differential current decay profiles of epithelial sodium channel subunit combinations in polarized renal epithelial cells. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
39 19144862 Regulation of ENaC-mediated sodium transport by glucocorticoids in Reissner's membrane epithelium. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
40 25900089 Assessment of epithelial sodium channel variants in nonwhite cystic fibrosis patients with non-diagnostic CFTR genotypes. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
41 15914781 Vascular ENaC proteins are required for renal myogenic constriction. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
42 8589728 Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
43 18665318 Epithelial sodium channel in a human trophoblast cell line (BeWo). Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
44 15096495 Fluorescence resonance energy transfer analysis of subunit stoichiometry of the epithelial Na+ channel. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
45 15459247 Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
46 1979052 Chromosomal distribution of three members of the human natriuretic peptide receptor/guanylyl cyclase gene family. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
47 19763606 Anionic phospholipids differentially regulate the epithelial sodium channel (ENaC) by interacting with alpha, beta, and gamma ENaC subunits. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
48 10409305 Cloning and functional expression of the mouse epithelial sodium channel. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
49 15596218 Overexpression of epithelial sodium channels in epithelium of human urinary bladder with outlet obstruction. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
50 21562341 Common variants in epithelial sodium channel genes contribute to salt sensitivity of blood pressure: The GenSalt study. Pubmed 2.370E-11 8.391E-10 6.855E-9 4.699E-8 3 3
Show 45 more annotations

9: Interaction [Display Chart] 12 input genes in category / 188 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:NPPC NPPC interactions 2.535E-11 4.767E-9 2.772E-8 4.767E-9 4 10
2 int:NPR3 NPR3 interactions 2.378E-9 2.235E-7 1.300E-6 4.470E-7 3 5
3 int:NPR2 NPR2 interactions 4.754E-9 2.979E-7 1.733E-6 8.937E-7 3 6
4 int:NPPA NPPA interactions 2.317E-8 1.089E-6 6.334E-6 4.356E-6 4 48
5 int:NPR1 NPR1 interactions 3.914E-8 1.227E-6 7.134E-6 7.359E-6 3 11
6 int:NPPB NPPB interactions 3.914E-8 1.227E-6 7.134E-6 7.359E-6 3 11
7 int:SERP1 SERP1 interactions 6.780E-8 1.821E-6 1.059E-5 1.275E-5 3 13
8 int:NEDD4L NEDD4L interactions 1.821E-7 4.033E-6 2.346E-5 3.424E-5 5 214
9 int:SCNN1G SCNN1G interactions 1.931E-7 4.033E-6 2.346E-5 3.630E-5 3 18
10 int:SCNN1A SCNN1A interactions 5.427E-7 1.020E-5 5.935E-5 1.020E-4 3 25
11 int:SCNN1B SCNN1B interactions 6.133E-7 1.048E-5 6.097E-5 1.153E-4 3 26
12 int:AP1M2 AP1M2 interactions 2.145E-6 3.361E-5 1.955E-4 4.033E-4 3 39
13 int:EPN1 EPN1 interactions 1.270E-5 1.705E-4 9.917E-4 2.387E-3 3 70
14 int:SGK1 SGK1 interactions 1.270E-5 1.705E-4 9.917E-4 2.387E-3 3 70
15 int:STX1A STX1A interactions 1.627E-5 2.039E-4 1.186E-3 3.059E-3 3 76
16 int:USP8 USP8 interactions 2.278E-5 2.677E-4 1.557E-3 4.282E-3 3 85
17 int:USP2 USP2 interactions 4.930E-5 5.452E-4 3.171E-3 9.269E-3 3 110
18 int:KLHL3 KLHL3 interactions 1.057E-4 1.046E-3 6.085E-3 1.988E-2 2 23
19 int:SCNN1D SCNN1D interactions 1.057E-4 1.046E-3 6.085E-3 1.988E-2 2 23
20 int:HECW1 HECW1 interactions 1.153E-4 1.084E-3 6.304E-3 2.168E-2 2 24
21 int:WWP2 WWP2 interactions 2.942E-4 2.633E-3 1.532E-2
5.530E-2
 3 201
22 int:KLHL2 KLHL2 interactions 9.915E-4 8.473E-3 4.928E-2
1.864E-1
 2 70
23 int:NEDD4 NEDD4 interactions 1.120E-3 8.908E-3
5.181E-2
2.105E-1
 3 318
24 int:COMMD1 COMMD1 interactions 1.137E-3 8.908E-3
5.181E-2
2.138E-1
 2 75
25 int:PM20D1 PM20D1 interactions 2.032E-3 1.470E-2
8.547E-2
3.821E-1
 1 3
26 int:BPIFB3 BPIFB3 interactions 2.032E-3 1.470E-2
8.547E-2
3.821E-1
 1 3
27 int:MME MME interactions 2.468E-3 1.719E-2
9.996E-2
4.640E-1
 2 111
28 int:SEMA3A SEMA3A interactions 3.385E-3 2.273E-2
1.322E-1
6.364E-1
 1 5
29 int:MXRA7 MXRA7 interactions 4.061E-3 2.545E-2
1.480E-1
7.634E-1
 1 6
30 int:CLDN4 CLDN4 interactions 4.061E-3 2.545E-2
1.480E-1
7.634E-1
 1 6
31 int:GDPD3 GDPD3 interactions 4.736E-3 2.872E-2
1.671E-1
8.904E-1
 1 7
32 int:ALOX15B ALOX15B interactions 6.086E-3 3.365E-2
1.957E-1
1.000E0
 1 9
33 int:CLDN3 CLDN3 interactions 6.086E-3 3.365E-2
1.957E-1
1.000E0
 1 9
34 int:NUDT8 NUDT8 interactions 6.086E-3 3.365E-2
1.957E-1
1.000E0
 1 9
35 int:METTL6 METTL6 interactions 6.760E-3 3.583E-2
2.084E-1
1.000E0
 1 10
36 int:UBQLN4 UBQLN4 interactions 7.263E-3 3.583E-2
2.084E-1
1.000E0
 2 193
37 int:ITCH ITCH interactions 7.263E-3 3.583E-2
2.084E-1
1.000E0
 2 193
38 int:SYT2 SYT2 interactions 7.433E-3 3.583E-2
2.084E-1
1.000E0
 1 11
39 int:CLDN2 CLDN2 interactions 7.433E-3 3.583E-2
2.084E-1
1.000E0
 1 11
40 int:GUCY1A1 GUCY1A1 interactions 8.106E-3 3.668E-2
2.133E-1
1.000E0
 1 12
41 int:GUCY1A2 GUCY1A2 interactions 8.779E-3 3.668E-2
2.133E-1
1.000E0
 1 13
42 int:SLC12A3 SLC12A3 interactions 8.779E-3 3.668E-2
2.133E-1
1.000E0
 1 13
43 int:NOX5 NOX5 interactions 8.779E-3 3.668E-2
2.133E-1
1.000E0
 1 13
44 int:SDR9C7 SDR9C7 interactions 8.779E-3 3.668E-2
2.133E-1
1.000E0
 1 13
45 int:CLDN1 CLDN1 interactions 8.779E-3 3.668E-2
2.133E-1
1.000E0
 1 13
46 int:NFASC NFASC interactions 9.452E-3 3.781E-2
2.199E-1
1.000E0
 1 14
47 int:BPIFA1 BPIFA1 interactions 9.452E-3 3.781E-2
2.199E-1
1.000E0
 1 14
48 int:WNK2 WNK2 interactions 1.012E-2 3.884E-2
2.259E-1
1.000E0
 1 15
49 int:METAP1 METAP1 interactions 1.012E-2 3.884E-2
2.259E-1
1.000E0
 1 15
50 int:WNK4 WNK4 interactions 1.080E-2 4.059E-2
2.361E-1
1.000E0
 1 16
Show 45 more annotations

10: Cytoband [Display Chart] 12 input genes in category / 12 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 4q31.3-q33 4q31.3-q33 3.462E-4 2.077E-3 6.445E-3 4.155E-3 1 1
2 16p12.2-p12.1 16p12.2-p12.1 3.462E-4 2.077E-3 6.445E-3 4.155E-3 1 1
3 9p21-p12 9p21-p12 6.923E-4 2.077E-3 6.445E-3 8.308E-3 1 2
4 5p14-p13 5p14-p13 6.923E-4 2.077E-3 6.445E-3 8.308E-3 1 2
5 17q21-q22 17q21-q22 2.767E-3 6.640E-3 2.060E-2 3.320E-2 1 8
6 2q24 2q24 3.802E-3 7.605E-3 2.360E-2 4.563E-2 1 11
7 16p12 16p12 5.182E-3 8.883E-3 2.757E-2
6.218E-2
 1 15
8 1q21-q22 1q21-q22 7.935E-3 1.190E-2 3.694E-2
9.522E-2
 1 23
9 20q11.2 20q11.2 9.309E-3 1.241E-2 3.850E-2
1.117E-1
 1 27
10 12p13.3 12p13.3 1.034E-2 1.241E-2 3.850E-2
1.241E-1
 1 30
11 12p13 12p13 2.262E-2 2.467E-2
7.656E-2
2.714E-1
 1 66
12 1p36.21 1p36.21 2.499E-2 2.499E-2
7.754E-2
2.998E-1
 1 73
Show 7 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 99 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 11 input genes in category / 8 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 185 Sodium channels epithelial genenames.org 6.574E-10 5.259E-9 1.429E-8 5.259E-9 3 4
2 343 Guanylate cyclase receptors genenames.org 6.967E-6 2.787E-5 7.574E-5 5.574E-5 2 7
3 504 DENN/MADD domain containing|Pleckstrin homology domain containing|Myotubularins genenames.org 9.894E-5 2.638E-4 7.171E-4 7.915E-4 2 25
4 820 Guanylate cyclases, soluble genenames.org 2.416E-3 4.833E-3 1.313E-2 1.933E-2 1 4
5 542 Endogenous ligands genenames.org 8.601E-3 1.284E-2 3.491E-2
6.880E-2
 2 237
6 456 BPI fold containing genenames.org 9.634E-3 1.284E-2 3.491E-2
7.707E-2
 1 16
7 870 Minor histocompatibility antigens|FERM domain containing genenames.org 3.041E-2 3.476E-2
9.447E-2
2.433E-1
 1 51
Show 2 more annotations

13: Coexpression [Display Chart] 12 input genes in category / 905 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14238 Candidate genes in the pericentromeric microdeletion in 16p11.2-p12.2 associated with developmental disabilities. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.917E-5 1.735E-2
1.282E-1
 1.735E-2 2 13
2 19129520-TableS26 Human StemCell Mullighan09 35genes GeneSigDB 1.290E-4 3.481E-2
2.571E-1
1.168E-1
 2 33
3 19658189-TableS8a Human EmbryonicStemCell Xu09 36genes GeneSigDB 1.538E-4 3.481E-2
2.571E-1
1.392E-1
 2 36
4 M16637 Genes up-regulated in HET1A cells (esophagus epithelium) engineered to stably express CDX2 [GeneID=1045]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.538E-4 3.481E-2
2.571E-1
1.392E-1
 2 36

14: Coexpression Atlas [Display Chart] 12 input genes in category / 1037 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Lungmap Mouse Lung PND1 Epithelial Subtype AT1-D Lungmap Mouse Lung PND1 Epithelial Subtype AT1-D Lungmap CCHMC 4.921E-6 4.173E-3 3.139E-2 5.103E-3 4 223
2 BM Top 100 - kidney medulla BM Top 100 - kidney medulla Body Map 8.049E-6 4.173E-3 3.139E-2 8.346E-3 3 74
3 gudmap kidney adult JuxtaGlom Ren1 k2 1000 kidney adult JuxtaGlom Ren1 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.390E-5 4.753E-3 3.575E-2 2.479E-2 4 333
4 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 - meso PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 - meso PND01-03 Top 200 Genes 3.037E-5 4.753E-3 3.575E-2 3.149E-2 4 354
5 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 PND01-03 Top 200 Genes 3.071E-5 4.753E-3 3.575E-2 3.184E-2 4 355
6 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 Top 200 Genes 3.173E-5 4.753E-3 3.575E-2 3.291E-2 4 358
7 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 - meso Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 - meso Top 200 Genes 3.208E-5 4.753E-3 3.575E-2 3.327E-2 4 359
8 gudmap developingKidney e15.5 Medullary collecting duct 100 k5 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#5 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 4.218E-5 5.467E-3 4.112E-2 4.374E-2 2 18
9 cervix, uterine cervix, uterine Human Protein Atlas 6.554E-5 6.948E-3
5.226E-2
6.797E-2
 3 149
10 gudmap developingKidney e15.5 cortic collect duct 1000 k2 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 6.954E-5 6.948E-3
5.226E-2
7.212E-2
 3 152
11 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/2/0 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal Carcinoma/2/0 TCGA-Breast 7.370E-5 6.948E-3
5.226E-2
7.643E-2
 3 155
12 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup4/Nell1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup4/Nell1 BrainMap 1.130E-4 9.762E-3
7.343E-2
1.171E-1
 3 179
13 gudmap developingLowerUrinaryTract e15.5 Urothelium 200 k4 DevelopingLowerUrinaryTract e15.5 Urothelium emap-28091 k-means-cluster#4 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.245E-4 1.791E-2
1.347E-1
2.328E-1
 2 41
14 Lungmap Lungmap - Mouse FluidigmC1 Epithelial Epithelial Subtype AT1 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Epithelial Epithelial Subtype AT1 Top 200 Genes 2.885E-4 2.091E-2
1.573E-1
2.992E-1
 3 246
15 Lungmap Mouse Lung PND3 Epithelial Subtype AT2-A Lungmap Mouse Lung PND3 Epithelial Subtype AT2-A Lungmap CCHMC 3.133E-4 2.091E-2
1.573E-1
3.249E-1
 3 253
16 Lungmap Mouse Lung PND3 Epithelial Subtype AT1 Lungmap Mouse Lung PND3 Epithelial Subtype AT1 Lungmap CCHMC 3.394E-4 2.091E-2
1.573E-1
3.519E-1
 3 260
17 Lungmap Lungmap - Mouse FluidigmC1 Epithelial Epithelial Subtype AT1 PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Epithelial Epithelial Subtype AT1 PND01-03 Top 200 Genes 3.668E-4 2.091E-2
1.573E-1
3.804E-1
 3 267
18 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Papillary Adenocarcinoma/2/1 Sample Type by Project: Shred 1/TCGA-Lung/Lung Carcinoma/Lung Papillary Adenocarcinoma/2/1 TCGA-Lung 3.758E-4 2.091E-2
1.573E-1
3.898E-1
 2 53
19 Lungmap Lungmap - Mouse FluidigmC1 Epithelial Epithelial Subtype AT1 - meso PND01-03 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Epithelial Epithelial Subtype AT1 - meso PND01-03 Top 200 Genes 3.832E-4 2.091E-2
1.573E-1
3.973E-1
 3 271
20 gudmap developingKidney e15.5 cortic collect duct 200 k1 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 4.502E-4 2.334E-2
1.756E-1
4.668E-1
 2 58
21 gudmap developingKidney e15.5 Medullary collecting duct 200 k5 DevelopingKidney e15.5 Medullary collecting duct emap-28063 k-means-cluster#5 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 6.367E-4 3.014E-2
2.267E-1
6.603E-1
 2 69
22 kidney kidney Human Protein Atlas 6.395E-4 3.014E-2
2.267E-1
6.632E-1
 3 323
23 gudmap RNAseq e15.5 Podocytes 2500 K2 gudmap RNAseq e15.5 Podocytes 2500 K2 Gudmap RNAseq 7.049E-4 3.058E-2
2.300E-1
7.310E-1
 3 334
24 BM Top 100 - trachea BM Top 100 - trachea Body Map 7.124E-4 3.058E-2
2.300E-1
7.388E-1
 2 73
25 BM Top 100 - bronchus BM Top 100 - bronchus Body Map 7.922E-4 3.058E-2
2.300E-1
8.215E-1
 2 77
26 DevelopingKidney e15.5 Medullary collecting duct emap-28063 100 DevelopingKidney e15.5 Medullary collecting duct emap-28063 top-relative-expression-ranked 100 Gudmap Mouse MOE430.2 8.337E-4 3.058E-2
2.300E-1
8.645E-1
 2 79
27 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Yolk Sac Tumor/3/4 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Embryonal Carcinoma, Yolk Sac Tumor/3/4 TCGA-Testes 8.337E-4 3.058E-2
2.300E-1
8.645E-1
 2 79
28 gudmap kidney adult RenMedVasc Tie2 k3 1000 kidney adult RenMedVasc Tie2 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 8.548E-4 3.058E-2
2.300E-1
8.864E-1
 2 80
29 Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 - meso E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Epithelial Subtype AT1 - meso E18.5 Top 200 Genes 8.551E-4 3.058E-2
2.300E-1
8.868E-1
 3 357
30 BM Top 100 - kidney cortex BM Top 100 - kidney cortex Body Map 9.418E-4 3.256E-2
2.449E-1
9.767E-1
 2 84
31 gudmap RNAseq e11.5 Ureteric bud 2500 K3 gudmap RNAseq e11.5 Ureteric bud 2500 K3 Gudmap RNAseq 9.869E-4 3.276E-2
2.464E-1
1.000E0
 2 86
32 gudmap developingKidney e15.5 ureter tip flank cortic collct 500 k4 DevelopingKidney e15.5 ureter tip flank cortic collct emap-27752 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.056E-3 3.276E-2
2.464E-1
1.000E0
 2 89
33 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3/C1ql2 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3/C1ql2 BrainMap 1.080E-3 3.276E-2
2.464E-1
1.000E0
 2 90
34 gudmap developingKidney e15.5 cortic collect duct 500 k5 DevelopingKidney e15.5 cortic collect duct emap-28132 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.128E-3 3.276E-2
2.464E-1
1.000E0
 2 92
35 GSM538268 500 Myeloid Cells, DC.IIhilang+103+11blo.SLN, MHCIIhi CD11c+ Langerin+ CD103+ CD11b-, Lymph Node, avg-3 Immgen.org, GSE15907 1.137E-3 3.276E-2
2.464E-1
1.000E0
 3 394
36 gudmap developingKidney e15.5 Medullary collecting duct 500 DevelopingKidney e15.5 Medullary collecting duct emap-28063 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.137E-3 3.276E-2
2.464E-1
1.000E0
 3 394
37 gudmap kidney adult JuxtaGlom Ren1 500 kidney adult JuxtaGlom Ren1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.197E-3 3.350E-2
2.520E-1
1.000E0
 3 401
38 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/kidney collecting duct epithelial cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Kidney/kidney collecting duct epithelial cell Tabula Muris Consortium 1.228E-3 3.350E-2
2.520E-1
1.000E0
 2 96
39 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Diffuse/2/3 Sample Type by Project: Shred 1/TCGA-Stomach/Stomach Adenocarcinoma/Stomach Adenocarcinoma - Diffuse/2/3 TCGA-Stomach 1.357E-3 3.609E-2
2.715E-1
1.000E0
 2 101
40 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type AB/3/3 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type AB/3/3 TCGA-Thymus 1.411E-3 3.658E-2
2.752E-1
1.000E0
 2 103
41 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/6 Sample Type by Project: Shred 1/TCGA-Esophagus/Esophageal Carcinoma/Esophagus Squamous Cell Carcinoma/6 TCGA-Esophagus 1.578E-3 3.875E-2
2.915E-1
1.000E0
 2 109
42 gudmap kidney adult JuxtaGlom Ren1 Captopr k2 1000 kidney adult JuxtaGlom Ren1 Captopr k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.583E-3 3.875E-2
2.915E-1
1.000E0
 3 442
43 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup7/Tac2/Tac2,Syt15 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup7/Tac2/Tac2,Syt15 BrainMap 1.607E-3 3.875E-2
2.915E-1
1.000E0
 2 110
44 gudmap kidney P4 CapMesRenVes Crym k4 1000 kidney P4 CapMesRenVes Crym k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.724E-3 3.921E-2
2.949E-1
1.000E0
 2 114
45 gudmap developingKidney e15.5 Peripheral blastema 200 k2 DevelopingKidney e15.5 Peripheral blastema emap-27731 k-means-cluster#2 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.785E-3 3.921E-2
2.949E-1
1.000E0
 2 116
46 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/4 Sample Type by Project: Shred 1/TCGA-Prostate/Prostate Adenocarcinoma /Acinar Adenocarcinoma/4 TCGA-Prostate 1.785E-3 3.921E-2
2.949E-1
1.000E0
 2 116
47 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex Wilms IF-U/Kidney Normal-Cortex Wilms IF14 Adult, Development, and Cancer types 1.815E-3 3.921E-2
2.949E-1
1.000E0
 2 117
48 BrainMap BrainAtlas - Mouse McCarroll Cerebellum Cerebellum Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Cerebellum Cerebellum Overall Top 200 Genes BrainMap 1.815E-3 3.921E-2
2.949E-1
1.000E0
 2 117
49 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B2/2/5 Sample Type by Project: Shred 1/TCGA-Thymus/Thymoma/Type B2/2/5 TCGA-Thymus 2.003E-3 4.139E-2
3.113E-1
1.000E0
 2 123
50 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal and Lobular Carcinoma/5 Sample Type by Project: Shred 1/TCGA-Breast/Breast Carcinoma/Infiltrating Ductal and Lobular Carcinoma/5 TCGA-Breast 2.003E-3 4.139E-2
3.113E-1
1.000E0
 2 123
Show 45 more annotations

15: Computational [Display Chart] 10 input genes in category / 43 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11146 MODULE 65 Genes in the cancer module 65. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.516E-8 3.662E-6 1.593E-5 3.662E-6 3 10
2 M11007 MODULE 445 Genes in the cancer module 445. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.221E-7 6.924E-6 3.012E-5 1.385E-5 3 15

16: MicroRNA [Display Chart] 12 input genes in category / 299 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-550a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.120E-4 2.760E-2
1.733E-1
 3.348E-2 2 95
2 hsa-miR-944:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.846E-4 2.760E-2
1.733E-1
5.521E-2
 2 122

17: Drug [Display Chart] 12 input genes in category / 4142 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011979316 vasopressin Stitch 1.142E-16 2.980E-13 2.654E-12 4.730E-13 10 388
2 CID000005839 aldosterone Stitch 1.439E-16 2.980E-13 2.654E-12 5.960E-13 10 397
3 CID000003001 NSC9567 Stitch 8.363E-16 1.155E-12 1.028E-11 3.464E-12 8 141
4 CID000130279 Ap 811 Stitch 1.925E-15 1.993E-12 1.775E-11 7.974E-12 5 9
5 CID003035839 Rp-8-Br-cGMPS Stitch 4.352E-14 3.605E-11 3.211E-10 1.803E-10 6 46
6 CID000005413 tetraethylammonium Stitch 5.510E-14 3.804E-11 3.388E-10 2.282E-10 8 236
7 CID000007054 isatin Stitch 8.358E-14 4.945E-11 4.405E-10 3.462E-10 6 51
8 CID000011840 5-methylisatin Stitch 2.182E-13 1.130E-10 1.006E-9 9.039E-10 4 5
9 CID000003843 AC1L1GU8 Stitch 2.846E-13 1.310E-10 1.166E-9 1.179E-9 6 62
10 CID000160802 MnGTP Stitch 4.010E-13 1.661E-10 1.479E-9 1.661E-9 5 22
11 CID000123969 8-pCPT-cGMP Stitch 4.615E-13 1.738E-10 1.548E-9 1.911E-9 6 67
12 CID000003758 IBMX Stitch 1.970E-12 6.799E-10 6.055E-9 8.159E-9 8 368
13 CID000004826 pinacidil Stitch 2.325E-12 7.383E-10 6.576E-9 9.628E-9 6 87
14 CID005490906 atrial peptide Stitch 2.581E-12 7.383E-10 6.576E-9 1.069E-8 5 31
15 CID000410009 AC1L8Y60 Stitch 2.674E-12 7.383E-10 6.576E-9 1.107E-8 6 89
16 CID000092977 8-bromoguanosine Stitch 3.504E-12 9.071E-10 8.079E-9 1.451E-8 6 93
17 CID000005212 sildenafil Stitch 4.259E-12 1.038E-9 9.241E-9 1.764E-8 6 96
18 CID005488765 Uroguanylin Stitch 5.720E-12 1.316E-9 1.172E-8 2.369E-8 5 36
19 CID000020382 tetradotoxin Stitch 6.603E-12 1.440E-9 1.282E-8 2.735E-8 8 428
20 CID000002720 thiazide Stitch 6.958E-12 1.441E-9 1.283E-8 2.882E-8 6 104
21 CID000003976 LY83583 Stitch 7.378E-12 1.455E-9 1.296E-8 3.056E-8 6 105
22 CID000002315 bendrofluazide Stitch 8.729E-12 1.644E-9 1.464E-8 3.616E-8 5 39
23 CID011947681 nitroprusside Stitch 1.037E-11 1.867E-9 1.663E-8 4.294E-8 6 111
24 CID003036959 PDEs Stitch 1.357E-11 2.342E-9 2.086E-8 5.621E-8 6 116
25 CID000163608 DEANO Stitch 1.458E-11 2.416E-9 2.151E-8 6.039E-8 5 43
26 CID000001727 4-AP Stitch 1.632E-11 2.469E-9 2.199E-8 6.761E-8 7 258
27 CID005489468 guanylin Stitch 1.644E-11 2.469E-9 2.199E-8 6.811E-8 5 44
28 CID000003639 hydrochlorothiazide Stitch 1.669E-11 2.469E-9 2.199E-8 6.913E-8 6 120
29 CID000036095 dibutyryl cyclic GMP Stitch 2.719E-11 3.883E-9 3.458E-8 1.126E-7 6 130
30 CID000005231 S-nitroso-N-acetyl-D,L-penicillamine Stitch 3.269E-11 4.514E-9 4.020E-8 1.354E-7 6 134
31 CID000065388 SIN-1 chloride Stitch 4.335E-11 5.768E-9 5.137E-8 1.796E-7 5 53
32 CID000005722 zaprinast Stitch 4.456E-11 5.768E-9 5.137E-8 1.846E-7 6 141
33 ctd:C055656 8-((4-chlorophenyl)thio)cyclic-3',5'-GMP CTD 5.941E-11 7.457E-9 6.641E-8 2.461E-7 4 15
34 CID000004197 milrinone Stitch 6.488E-11 7.904E-9 7.040E-8 2.687E-7 6 150
35 CID000001918 AC1L1CIR Stitch 6.914E-11 8.182E-9 7.287E-8 2.864E-7 5 58
36 CID000001433 1400 W Stitch 7.552E-11 8.689E-9 7.738E-8 3.128E-7 5 59
37 CID000127189 Anp (1-11) Stitch 7.919E-11 8.865E-9 7.896E-8 3.280E-7 4 16
38 CID000168120 8-Br Stitch 8.231E-11 8.972E-9 7.990E-8 3.409E-7 6 156
39 DB04899 Nesiritide Drug Bank 1.108E-10 1.177E-8 1.048E-7 4.589E-7 3 3
40 CID000004366 L-NMMA Stitch 1.595E-10 1.651E-8 1.471E-7 6.605E-7 6 174
41 CID000001456 OD-q Stitch 1.893E-10 1.912E-8 1.703E-7 7.839E-7 6 179
42 CID000047528 nicorandil Stitch 1.958E-10 1.931E-8 1.720E-7 8.110E-7 5 71
43 CID000107754 diethylamine NONOate Stitch 2.104E-10 1.938E-8 1.726E-7 8.713E-7 5 72
44 CID000123697 candoxatrilat Stitch 2.106E-10 1.938E-8 1.726E-7 8.722E-7 4 20
45 CID000123742 SQ 28,603 Stitch 2.106E-10 1.938E-8 1.726E-7 8.722E-7 4 20
46 CID000003780 CAS 87-33-2 Stitch 2.258E-10 2.033E-8 1.810E-7 9.351E-7 5 73
47 CID000003488 glibenclamide Stitch 2.553E-10 2.250E-8 2.004E-7 1.058E-6 7 382
48 ctd:D011692 Puromycin Aminonucleoside CTD 2.890E-10 2.494E-8 2.221E-7 1.197E-6 6 192
49 CID005360741 alternariol monomethyl ether Stitch 2.967E-10 2.508E-8 2.233E-7 1.229E-6 5 77
50 DB00384 Triamterene Drug Bank 4.430E-10 3.670E-8 3.269E-7 1.835E-6 3 4
Show 45 more annotations

18: Disease [Display Chart] 12 input genes in category / 370 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0033805 Pseudohypoaldosteronism DisGeNET Curated 3.702E-13 1.370E-10 8.894E-10 1.370E-10 5 16
2 cv:C1449843 Pseudohypoaldosteronism type 1 autosomal recessive Clinical Variations 3.102E-10 4.275E-8 2.776E-7 1.148E-7 3 3
3 C0085580 Essential Hypertension DisGeNET Curated 3.466E-10 4.275E-8 2.776E-7 1.283E-7 7 284
4 C1449843 Pseudohypoaldosteronism, Type I, Autosomal Recessive DisGeNET Curated 1.240E-9 1.147E-7 7.449E-7 4.590E-7 3 4
5 C0030779 Pelger-Huet Anomaly DisGeNET Curated 2.554E-9 1.890E-7 1.227E-6 9.450E-7 4 26
6 C3150267 Increased plasma renin activity DisGeNET Curated 1.734E-8 9.164E-7 5.949E-6 6.415E-6 3 8
7 C1846345 Hyperactive renin-angiotensin system DisGeNET Curated 1.734E-8 9.164E-7 5.949E-6 6.415E-6 3 8
8 C0268436 Pseudohypoaldosteronism, Type I DisGeNET BeFree 5.102E-8 2.360E-6 1.532E-5 1.888E-5 3 11
9 C0339985 Idiopathic bronchiectasis DisGeNET Curated 1.728E-7 6.467E-6 4.198E-5 6.394E-5 3 16
10 C0221043 Liddle Syndrome DisGeNET Curated 2.097E-7 6.467E-6 4.198E-5 7.760E-5 3 17
11 C0020461 Hyperkalemia DisGeNET Curated 2.097E-7 6.467E-6 4.198E-5 7.760E-5 3 17
12 C3854315 Pseudoprimary hyperaldosteronism DisGeNET BeFree 2.097E-7 6.467E-6 4.198E-5 7.760E-5 3 17
13 C1846347 Renal salt wasting DisGeNET Curated 2.516E-7 7.160E-6 4.649E-5 9.309E-5 3 18
14 C0020649 Hypotension DisGeNET Curated 2.923E-7 7.724E-6 5.015E-5 1.081E-4 4 82
15 OMIN:177200 LIDDLE SYNDROME OMIM 5.027E-7 1.162E-5 7.547E-5 1.860E-4 2 2
16 cv:C0221043 Pseudoprimary hyperaldosteronism Clinical Variations 5.027E-7 1.162E-5 7.547E-5 1.860E-4 2 2
17 C1301700 Cardiovascular morbidity DisGeNET BeFree 1.378E-6 3.000E-5 1.948E-4 5.100E-4 3 31
18 C0020625 Hyponatremia DisGeNET Curated 2.579E-6 5.302E-5 3.442E-4 9.544E-4 3 38
19 OMIN:145260 PSEUDOHYPOALDOSTERONISM, TYPE II; PHA2 OMIM 3.014E-6 5.575E-5 3.620E-4 1.115E-3 2 4
20 C1864356 ACROMESOMELIC DYSPLASIA, MAROTEAUX TYPE DisGeNET Curated 3.014E-6 5.575E-5 3.620E-4 1.115E-3 2 4
21 C0220981 Metabolic acidosis DisGeNET Curated 4.039E-6 7.117E-5 4.620E-4 1.495E-3 3 44
22 C0020428 Hyperaldosteronism DisGeNET Curated 4.626E-6 7.780E-5 5.051E-4 1.712E-3 3 46
23 C4049883 Obstructive Ureterocele DisGeNET BeFree 5.266E-6 8.472E-5 5.500E-4 1.949E-3 3 48
24 C0008677 Bronchitis, Chronic DisGeNET Curated 7.533E-6 1.161E-4 7.540E-4 2.787E-3 3 54
25 C0085570 Hypokalemic alkalosis DisGeNET Curated 1.053E-5 1.559E-4 1.012E-3 3.898E-3 2 7
26 C0220666 ARTHROGRYPOSIS MULTIPLEX CONGENITA, DISTAL, TYPE IIA DisGeNET Curated 1.804E-5 2.473E-4 1.605E-3 6.677E-3 2 9
27 C1845206 Decreased plasma renin activity DisGeNET Curated 1.804E-5 2.473E-4 1.605E-3 6.677E-3 2 9
28 C0006267 Bronchiectasis DisGeNET Curated 2.033E-5 2.686E-4 1.744E-3 7.522E-3 3 75
29 20090724:Estrada Height GWAS 2.255E-5 2.877E-4 1.868E-3 8.342E-3 2 10
30 C3469605 PSEUDOHYPOALDOSTERONISM, TYPE IID DisGeNET Curated 2.755E-5 3.397E-4 2.206E-3 1.019E-2 2 11
31 C0011175 Dehydration DisGeNET Curated 2.961E-5 3.534E-4 2.295E-3 1.096E-2 3 85
32 C1846226 Mineralocorticoid insufficiency DisGeNET Curated 3.304E-5 3.820E-4 2.480E-3 1.223E-2 2 12
33 C1449844 Pseudohypoaldosteronism, Type II DisGeNET BeFree 4.552E-5 5.104E-4 3.313E-3 1.684E-2 2 14
34 C0024115 Lung diseases DisGeNET Curated 9.129E-5 9.935E-4 6.450E-3 3.378E-2 4 349
35 C0020595 Hypoaldosteronism DisGeNET Curated 1.047E-4 1.107E-3 7.189E-3 3.876E-2 2 21
36 C3806482 Recurrent respiratory infections DisGeNET Curated 1.485E-4 1.475E-3 9.578E-3
5.494E-2
 3 146
37 C1408258 Kidney damage DisGeNET Curated 1.494E-4 1.475E-3 9.578E-3
5.527E-2
 2 25
38 C0042963 Vomiting DisGeNET Curated 1.515E-4 1.475E-3 9.578E-3
5.607E-2
 3 147
39 C0001080 Achondroplasia DisGeNET Curated 1.618E-4 1.535E-3 9.964E-3
5.985E-2
 2 26
40 C0598428 genetic hypertension DisGeNET BeFree 2.162E-4 2.000E-3 1.298E-2
7.998E-2
 2 30
41 C2674608 Feeding difficulties in infancy DisGeNET Curated 2.535E-4 2.288E-3 1.485E-2
9.380E-2
 3 175
42 C0020621 Hypokalemia DisGeNET Curated 2.621E-4 2.309E-3 1.499E-2
9.696E-2
 2 33
43 C0037315 Sleep Apnea Syndromes DisGeNET Curated 3.860E-4 3.322E-3 2.156E-2
1.428E-1
 2 40
44 C0013336 Dwarfism DisGeNET Curated 5.792E-4 3.703E-3 2.404E-2
2.143E-1
 3 232
45 C0917798 Cerebral Ischemia DisGeNET Curated 5.865E-4 3.703E-3 2.404E-2
2.170E-1
 3 233
46 C1848924 Infantile onset DisGeNET Curated 6.240E-4 3.703E-3 2.404E-2
2.309E-1
 3 238
47 C0153392 Malignant neoplasm of nasopharynx DisGeNET BeFree 6.530E-4 3.703E-3 2.404E-2
2.416E-1
 2 52
48 C0013720 Ehlers-Danlos Syndrome DisGeNET Curated 6.530E-4 3.703E-3 2.404E-2
2.416E-1
 2 52
49 C0238301 Cancer of Nasopharynx DisGeNET BeFree 6.530E-4 3.703E-3 2.404E-2
2.416E-1
 2 52
50 C1864361 Lower thoracic kyphosis DisGeNET Curated 7.405E-4 3.703E-3 2.404E-2
2.740E-1
 1 1
Show 45 more annotations