Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc16_14, positive side

Go To Start Page
Input Parameters [Show Detail]
Training Results [Expand All] [Download All] [Sparse Matrix]
Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 14 input genes in category / 97 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0017127 cholesterol transporter activity 1.534E-16 1.488E-14 7.675E-14 1.488E-14 6 14
2 GO:0015248 sterol transporter activity 9.471E-16 4.593E-14 2.369E-13 9.187E-14 6 18
3 GO:0015485 cholesterol binding 3.082E-13 9.964E-12 5.139E-11 2.989E-11 6 43
4 GO:0032934 sterol binding 6.192E-13 1.464E-11 7.548E-11 6.006E-11 6 48
5 GO:0043178 alcohol binding 7.691E-13 1.464E-11 7.548E-11 7.460E-11 7 112
6 GO:0055102 lipase inhibitor activity 9.053E-13 1.464E-11 7.548E-11 8.782E-11 5 18
7 GO:0005543 phospholipid binding 1.128E-12 1.563E-11 8.062E-11 1.094E-10 9 385
8 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity 2.970E-12 3.601E-11 1.857E-10 2.881E-10 4 6
9 GO:0070325 lipoprotein particle receptor binding 3.548E-12 3.824E-11 1.972E-10 3.442E-10 5 23
10 GO:0071813 lipoprotein particle binding 6.928E-12 6.110E-11 3.151E-10 6.720E-10 5 26
11 GO:0071814 protein-lipid complex binding 6.928E-12 6.110E-11 3.151E-10 6.720E-10 5 26
12 GO:0005496 steroid binding 7.070E-11 5.715E-10 2.947E-9 6.858E-9 6 103
13 GO:0005319 lipid transporter activity 1.620E-10 1.209E-9 6.235E-9 1.572E-8 6 118
14 GO:0070653 high-density lipoprotein particle receptor binding 3.361E-10 2.320E-9 1.197E-8 3.261E-8 3 3
15 GO:0034185 apolipoprotein binding 3.588E-10 2.320E-9 1.197E-8 3.481E-8 4 16
16 GO:0031210 phosphatidylcholine binding 1.741E-9 1.055E-8 5.442E-8 1.688E-7 4 23
17 GO:0008035 high-density lipoprotein particle binding 2.816E-8 1.607E-7 8.286E-7 2.732E-6 3 9
18 GO:0050997 quaternary ammonium group binding 6.134E-8 3.306E-7 1.705E-6 5.950E-6 4 54
19 GO:0070405 ammonium ion binding 2.883E-7 1.472E-6 7.591E-6 2.797E-5 4 79
20 GO:0017129 triglyceride binding 5.227E-7 2.535E-6 1.307E-5 5.070E-5 2 2
21 GO:0034186 apolipoprotein A-I binding 1.567E-6 7.240E-6 3.733E-5 1.520E-4 2 3
22 GO:0008201 heparin binding 5.775E-6 2.546E-5 1.313E-4 5.602E-4 4 167
23 GO:0004857 enzyme inhibitor activity 6.913E-6 2.916E-5 1.504E-4 6.706E-4 5 393
24 GO:0005548 phospholipid transporter activity 8.152E-6 3.295E-5 1.699E-4 7.907E-4 3 54
25 GO:0034190 apolipoprotein receptor binding 1.095E-5 4.250E-5 2.192E-4 1.062E-3 2 7
26 GO:0005539 glycosaminoglycan binding 1.685E-5 6.285E-5 3.241E-4 1.634E-3 4 219
27 GO:1901681 sulfur compound binding 3.302E-5 1.186E-4 6.118E-4 3.203E-3 4 260
28 GO:0030169 low-density lipoprotein particle binding 6.234E-5 2.160E-4 1.114E-3 6.047E-3 2 16
29 GO:0050750 low-density lipoprotein particle receptor binding 7.942E-5 2.657E-4 1.370E-3 7.704E-3 2 18
30 GO:0030228 lipoprotein particle receptor activity 8.873E-5 2.869E-4 1.479E-3 8.607E-3 2 19
31 GO:0004806 triglyceride lipase activity 1.197E-4 3.746E-4 1.932E-3 1.161E-2 2 22
32 GO:0001540 amyloid-beta binding 3.245E-4 9.837E-4 5.073E-3 3.148E-2 2 36
33 GO:0046911 metal chelating activity 7.502E-4 2.205E-3 1.137E-2
7.277E-2
 1 1
34 GO:0038024 cargo receptor activity 1.261E-3 3.597E-3 1.855E-2
1.223E-1
 2 71
35 GO:0035478 chylomicron binding 1.500E-3 3.829E-3 1.975E-2
1.455E-1
 1 2
36 GO:0070506 high-density lipoprotein particle receptor activity 1.500E-3 3.829E-3 1.975E-2
1.455E-1
 1 2
37 GO:0034188 apolipoprotein A-I receptor activity 1.500E-3 3.829E-3 1.975E-2
1.455E-1
 1 2
38 GO:0030226 apolipoprotein receptor activity 1.500E-3 3.829E-3 1.975E-2
1.455E-1
 1 2
39 GO:0060230 lipoprotein lipase activator activity 2.249E-3 5.594E-3 2.885E-2
2.182E-1
 1 3
40 GO:0034191 apolipoprotein A-I receptor binding 2.998E-3 7.092E-3 3.658E-2
2.908E-1
 1 4
41 GO:0070326 very-low-density lipoprotein particle receptor binding 2.998E-3 7.092E-3 3.658E-2
2.908E-1
 1 4
42 GO:0001875 lipopolysaccharide receptor activity 3.746E-3 8.533E-3 4.401E-2
3.634E-1
 1 5
43 GO:0004620 phospholipase activity 3.783E-3 8.533E-3 4.401E-2
3.669E-1
 2 124
44 GO:0035473 lipase binding 4.494E-3 9.906E-3
5.109E-2
4.359E-1
 1 6
45 GO:0016298 lipase activity 4.661E-3 1.005E-2
5.181E-2
4.521E-1
 2 138
46 GO:0046848 hydroxyapatite binding 5.241E-3 1.105E-2
5.699E-2
5.083E-1
 1 7
47 GO:0004465 lipoprotein lipase activity 5.987E-3 1.236E-2
6.372E-2
5.808E-1
 1 8
48 GO:0052689 carboxylic ester hydrolase activity 6.441E-3 1.302E-2
6.712E-2
6.248E-1
 2 163
49 GO:0048027 mRNA 5'-UTR binding 8.224E-3 1.564E-2
8.066E-2
7.977E-1
 1 11
50 GO:0008970 phospholipase A1 activity 8.224E-3 1.564E-2
8.066E-2
7.977E-1
 1 11
Show 45 more annotations

2: GO: Biological Process [Display Chart] 14 input genes in category / 825 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0071827 plasma lipoprotein particle organization 3.139E-32 2.590E-29 1.889E-28 2.590E-29 12 36
2 GO:0071825 protein-lipid complex subunit organization 9.804E-32 4.044E-29 2.950E-28 8.089E-29 12 39
3 GO:0034367 protein-containing complex remodeling 3.885E-31 6.411E-29 4.676E-28 3.205E-28 11 24
4 GO:0034368 protein-lipid complex remodeling 3.885E-31 6.411E-29 4.676E-28 3.205E-28 11 24
5 GO:0034369 plasma lipoprotein particle remodeling 3.885E-31 6.411E-29 4.676E-28 3.205E-28 11 24
6 GO:0097006 regulation of plasma lipoprotein particle levels 2.801E-29 3.851E-27 2.809E-26 2.311E-26 12 59
7 GO:0043691 reverse cholesterol transport 1.311E-25 1.545E-23 1.127E-22 1.081E-22 9 18
8 GO:0030301 cholesterol transport 6.458E-25 6.660E-23 4.857E-22 5.328E-22 11 74
9 GO:0015918 sterol transport 7.567E-25 6.936E-23 5.059E-22 6.243E-22 11 75
10 GO:0042632 cholesterol homeostasis 1.032E-24 7.739E-23 5.644E-22 8.513E-22 11 77
11 GO:0055092 sterol homeostasis 1.032E-24 7.739E-23 5.644E-22 8.513E-22 11 77
12 GO:0034370 triglyceride-rich lipoprotein particle remodeling 1.382E-24 8.769E-23 6.395E-22 1.140E-21 8 11
13 GO:0034372 very-low-density lipoprotein particle remodeling 1.382E-24 8.769E-23 6.395E-22 1.140E-21 8 11
14 GO:0042157 lipoprotein metabolic process 1.654E-24 9.747E-23 7.108E-22 1.365E-21 12 139
15 GO:0033344 cholesterol efflux 1.789E-24 9.838E-23 7.175E-22 1.476E-21 10 44
16 GO:0046503 glycerolipid catabolic process 1.139E-23 5.871E-22 4.282E-21 9.394E-21 10 52
17 GO:0034375 high-density lipoprotein particle remodeling 5.383E-23 2.612E-21 1.905E-20 4.441E-20 8 15
18 GO:0034381 plasma lipoprotein particle clearance 1.036E-22 4.745E-21 3.460E-20 8.546E-20 9 33
19 GO:0006641 triglyceride metabolic process 1.093E-22 4.745E-21 3.460E-20 9.015E-20 11 115
20 GO:0055088 lipid homeostasis 3.730E-22 1.465E-20 1.069E-19 3.077E-19 11 128
21 GO:0006639 acylglycerol metabolic process 3.730E-22 1.465E-20 1.069E-19 3.077E-19 11 128
22 GO:0006638 neutral lipid metabolic process 4.077E-22 1.529E-20 1.115E-19 3.363E-19 11 129
23 GO:0015914 phospholipid transport 4.626E-20 1.659E-18 1.210E-17 3.817E-17 9 61
24 GO:0033700 phospholipid efflux 1.431E-19 4.918E-18 3.587E-17 1.180E-16 7 15
25 GO:0010876 lipid localization 1.929E-19 6.366E-18 4.643E-17 1.591E-16 12 359
26 GO:0046461 neutral lipid catabolic process 3.209E-19 9.806E-18 7.152E-17 2.648E-16 8 37
27 GO:0046464 acylglycerol catabolic process 3.209E-19 9.806E-18 7.152E-17 2.648E-16 8 37
28 GO:0032374 regulation of cholesterol transport 6.387E-19 1.817E-17 1.325E-16 5.269E-16 8 40
29 GO:0032371 regulation of sterol transport 6.387E-19 1.817E-17 1.325E-16 5.269E-16 8 40
30 GO:0015850 organic hydroxy compound transport 1.215E-18 3.341E-17 2.437E-16 1.002E-15 11 262
31 GO:0015748 organophosphate ester transport 2.546E-18 6.776E-17 4.942E-16 2.101E-15 9 93
32 GO:0034377 plasma lipoprotein particle assembly 3.783E-18 9.753E-17 7.113E-16 3.121E-15 7 22
33 GO:0034384 high-density lipoprotein particle clearance 4.353E-18 1.088E-16 7.936E-16 3.591E-15 6 9
34 GO:0065005 protein-lipid complex assembly 1.065E-17 2.585E-16 1.885E-15 8.788E-15 7 25
35 GO:0006869 lipid transport 1.297E-17 3.058E-16 2.230E-15 1.070E-14 11 324
36 GO:0044242 cellular lipid catabolic process 1.417E-17 3.247E-16 2.368E-15 1.169E-14 10 198
37 GO:0019433 triglyceride catabolic process 5.815E-17 1.297E-15 9.457E-15 4.798E-14 7 31
38 GO:0070328 triglyceride homeostasis 7.441E-17 1.574E-15 1.148E-14 6.139E-14 7 32
39 GO:0055090 acylglycerol homeostasis 7.441E-17 1.574E-15 1.148E-14 6.139E-14 7 32
40 GO:0008203 cholesterol metabolic process 7.646E-17 1.577E-15 1.150E-14 6.308E-14 9 134
41 GO:1902652 secondary alcohol metabolic process 1.073E-16 2.158E-15 1.574E-14 8.849E-14 9 139
42 GO:0046486 glycerolipid metabolic process 1.631E-16 3.204E-15 2.337E-14 1.346E-13 11 407
43 GO:0016125 sterol metabolic process 1.798E-16 3.449E-15 2.515E-14 1.483E-13 9 147
44 GO:0016042 lipid catabolic process 1.060E-15 1.987E-14 1.449E-13 8.743E-13 10 303
45 GO:0034382 chylomicron remnant clearance 2.252E-15 4.038E-14 2.945E-13 1.858E-12 5 7
46 GO:0071830 triglyceride-rich lipoprotein particle clearance 2.252E-15 4.038E-14 2.945E-13 1.858E-12 5 7
47 GO:0032368 regulation of lipid transport 2.458E-15 4.314E-14 3.146E-13 2.028E-12 8 106
48 GO:0034374 low-density lipoprotein particle remodeling 4.946E-14 8.500E-13 6.199E-12 4.080E-11 5 11
49 GO:0032375 negative regulation of cholesterol transport 1.377E-13 2.271E-12 1.657E-11 1.136E-10 5 13
50 GO:0032372 negative regulation of sterol transport 1.377E-13 2.271E-12 1.657E-11 1.136E-10 5 13
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 14 input genes in category / 61 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034358 plasma lipoprotein particle 2.780E-28 8.479E-27 3.982E-26 1.696E-26 11 40
2 GO:1990777 lipoprotein particle 2.780E-28 8.479E-27 3.982E-26 1.696E-26 11 40
3 GO:0032994 protein-lipid complex 5.146E-28 1.046E-26 4.914E-26 3.139E-26 11 42
4 GO:0042627 chylomicron 8.944E-24 1.364E-22 6.405E-22 5.456E-22 8 13
5 GO:0034364 high-density lipoprotein particle 1.507E-23 1.838E-22 8.633E-22 9.192E-22 9 28
6 GO:0034385 triglyceride-rich plasma lipoprotein particle 8.737E-22 7.614E-21 3.576E-20 5.329E-20 8 20
7 GO:0034361 very-low-density lipoprotein particle 8.737E-22 7.614E-21 3.576E-20 5.329E-20 8 20
8 GO:0034363 intermediate-density lipoprotein particle 1.821E-13 1.388E-12 6.519E-12 1.111E-11 4 4
9 GO:0034366 spherical high-density lipoprotein particle 1.272E-11 8.623E-11 4.050E-10 7.761E-10 4 8
10 GO:0005769 early endosome 9.575E-10 5.841E-9 2.743E-8 5.841E-8 7 314
11 GO:0034362 low-density lipoprotein particle 1.143E-7 6.337E-7 2.976E-6 6.970E-6 3 14
12 GO:0071682 endocytic vesicle lumen 2.132E-7 1.084E-6 5.089E-6 1.300E-5 3 17
13 GO:0030139 endocytic vesicle 9.038E-7 4.241E-6 1.992E-5 5.513E-5 5 265
14 GO:0034365 discoidal high-density lipoprotein particle 1.502E-6 6.546E-6 3.074E-5 9.164E-5 2 3
15 GO:0005788 endoplasmic reticulum lumen 1.242E-5 5.050E-5 2.372E-4 7.576E-4 4 207
16 GO:0060205 cytoplasmic vesicle lumen 5.498E-5 2.096E-4 9.844E-4 3.354E-3 3 104
17 GO:0031983 vesicle lumen 6.153E-5 2.208E-4 1.037E-3 3.753E-3 3 108
18 GO:0072562 blood microparticle 1.417E-4 4.800E-4 2.254E-3 8.641E-3 3 143
19 GO:0034359 mature chylomicron 7.345E-4 2.240E-3 1.052E-2 4.480E-2 1 1
20 GO:0034360 chylomicron remnant 7.345E-4 2.240E-3 1.052E-2 4.480E-2 1 1
21 GO:0098857 membrane microdomain 1.814E-3 5.016E-3 2.356E-2
1.107E-1
 3 343
22 GO:0045121 membrane raft 1.814E-3 5.016E-3 2.356E-2
1.107E-1
 3 343
23 GO:0005902 microvillus 1.891E-3 5.016E-3 2.356E-2
1.154E-1
 2 89
24 GO:1990635 proximal dendrite 2.935E-3 7.161E-3 3.363E-2
1.790E-1
 1 4
25 GO:0097452 GAIT complex 2.935E-3 7.161E-3 3.363E-2
1.790E-1
 1 4
26 GO:0071204 histone pre-mRNA 3'end processing complex 4.399E-3 9.939E-3 4.668E-2
2.684E-1
 1 6
27 GO:0070937 CRD-mediated mRNA stability complex 4.399E-3 9.939E-3 4.668E-2
2.684E-1
 1 6
28 GO:0019897 extrinsic component of plasma membrane 5.398E-3 1.176E-2
5.523E-2
3.293E-1
 2 152
29 GO:0030666 endocytic vesicle membrane 5.678E-3 1.194E-2
5.609E-2
3.463E-1
 2 156
30 GO:0031232 extrinsic component of external side of plasma membrane 6.592E-3 1.340E-2
6.295E-2
4.021E-1
 1 9
31 GO:0098858 actin-based cell projection 9.531E-3 1.875E-2
8.807E-2
5.814E-1
 2 204
32 GO:0005770 late endosome 1.140E-2 2.173E-2
1.021E-1
6.954E-1
 2 224
33 GO:0031528 microvillus membrane 1.532E-2 2.832E-2
1.330E-1
9.345E-1
 1 21
34 GO:0019898 extrinsic component of membrane 1.718E-2 3.083E-2
1.448E-1
1.000E0
 2 278
35 GO:0031904 endosome lumen 1.893E-2 3.300E-2
1.550E-1
1.000E0
 1 26
36 GO:0009897 external side of plasma membrane 2.109E-2 3.573E-2
1.678E-1
1.000E0
 2 310
Show 31 more annotations

4: Human Phenotype [Display Chart] 10 input genes in category / 757 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0000991 Xanthomatosis 4.256E-14 2.973E-11 2.143E-10 3.222E-11 8 66
2 HP:0010980 Hyperlipoproteinemia 7.856E-14 2.973E-11 2.143E-10 5.947E-11 7 35
3 HP:0010979 Abnormality of lipoprotein cholesterol concentration 6.982E-12 1.762E-9 1.270E-8 5.286E-9 8 122
4 HP:0003107 Abnormality of cholesterol metabolism 3.228E-11 6.110E-9 4.404E-8 2.444E-8 9 254
5 HP:0003119 Abnormality of lipid metabolism 4.970E-11 7.524E-9 5.423E-8 3.762E-8 10 443
6 HP:0001114 Xanthelasma 1.111E-10 1.402E-8 1.010E-7 8.409E-8 5 18
7 HP:0003124 Hypercholesterolemia 1.803E-10 1.688E-8 1.216E-7 1.365E-7 7 100
8 HP:0010732 Nodular changes affecting the eyelids 2.007E-10 1.688E-8 1.216E-7 1.519E-7 5 20
9 HP:0010604 Cyst of the eyelid 2.007E-10 1.688E-8 1.216E-7 1.519E-7 5 20
10 HP:0003077 Hyperlipidemia 4.547E-10 3.442E-8 2.481E-7 3.442E-7 8 204
11 HP:0200040 Epidermoid cyst 1.263E-9 8.130E-8 5.859E-7 9.560E-7 5 28
12 HP:0001013 Eruptive xanthomas 1.289E-9 8.130E-8 5.859E-7 9.756E-7 4 9
13 HP:0025245 Cutaneous cyst 1.828E-9 1.064E-7 7.672E-7 1.384E-6 5 30
14 HP:0012184 Increased HDL cholesterol concentration 6.908E-9 3.735E-7 2.692E-6 5.230E-6 3 3
15 HP:0005181 Premature coronary artery atherosclerosis 1.388E-8 7.003E-7 5.047E-6 1.050E-5 4 15
16 HP:0010981 Hypolipoproteinemia 2.087E-8 9.873E-7 7.116E-6 1.580E-5 6 105
17 HP:0001084 Corneal arcus 2.414E-8 1.075E-6 7.749E-6 1.828E-5 4 17
18 HP:0008011 Peripheral opacification of the cornea 3.101E-8 1.304E-6 9.400E-6 2.348E-5 4 18
19 HP:0003233 Decreased HDL cholesterol concentration 6.047E-8 2.409E-6 1.736E-5 4.577E-5 4 21
20 HP:0001677 Coronary artery atherosclerosis 6.594E-8 2.496E-6 1.799E-5 4.992E-5 6 127
21 HP:0006704 Abnormal coronary artery morphology 7.245E-8 2.612E-6 1.882E-5 5.485E-5 6 129
22 HP:0002621 Atherosclerosis 4.204E-7 1.384E-5 9.973E-5 3.183E-4 6 173
23 HP:0002634 Arteriosclerosis 4.204E-7 1.384E-5 9.973E-5 3.183E-4 6 173
24 HP:0003563 Decreased LDL cholesterol concentration 5.649E-7 1.782E-5 1.284E-4 4.276E-4 5 91
25 HP:0200036 Skin nodule 4.513E-6 1.292E-4 9.310E-4 3.416E-3 5 138
26 HP:0100740 Embryotoxon 4.733E-6 1.292E-4 9.310E-4 3.583E-3 4 60
27 HP:0100545 Arterial stenosis 4.778E-6 1.292E-4 9.310E-4 3.617E-3 6 261
28 HP:0005114 Abnormalities of the peripheral arteries 4.778E-6 1.292E-4 9.310E-4 3.617E-3 6 261
29 HP:0002155 Hypertriglyceridemia 5.198E-6 1.357E-4 9.779E-4 3.935E-3 5 142
30 HP:0004416 Precocious atherosclerosis 5.544E-6 1.399E-4 1.008E-3 4.196E-3 3 18
31 HP:0003141 Increased LDL cholesterol concentration 1.042E-5 2.543E-4 1.833E-3 7.884E-3 3 22
32 HP:0012153 Hypotriglyceridemia 1.218E-5 2.880E-4 2.076E-3 9.217E-3 2 3
33 HP:0200034 Papule 1.580E-5 3.624E-4 2.612E-3 1.196E-2 5 178
34 HP:0001012 Multiple lipomas 2.513E-5 5.595E-4 4.032E-3 1.902E-2 4 91
35 HP:0200013 Neoplasm of fatty tissue 2.739E-5 5.760E-4 4.152E-3 2.074E-2 4 93
36 HP:0012031 Lipomatous tumor 2.739E-5 5.760E-4 4.152E-3 2.074E-2 4 93
37 HP:0007759 Opacification of the corneal stroma 2.858E-5 5.848E-4 4.215E-3 2.164E-2 4 94
38 HP:0011492 Abnormality of corneal stroma 3.107E-5 6.190E-4 4.461E-3 2.352E-2 4 96
39 HP:0001681 Angina pectoris 3.645E-5 7.075E-4 5.099E-3 2.759E-2 3 33
40 HP:0007957 Corneal opacity 5.496E-5 1.015E-3 7.314E-3 4.161E-2 5 230
41 HP:0000515 Corneal opacity 5.496E-5 1.015E-3 7.314E-3 4.161E-2 5 230
42 HP:0012397 Aortic atherosclerotic lesion 8.484E-5 1.529E-3 1.102E-2
6.422E-2
 2 7
43 HP:0010874 Tendon xanthomatosis 1.130E-4 1.989E-3 1.434E-2
8.554E-2
 2 8
44 HP:0002620 Systemic artery abnormality 1.438E-4 2.388E-3 1.721E-2
1.089E-1
 6 471
45 HP:0000799 Renal steatosis 1.451E-4 2.388E-3 1.721E-2
1.098E-1
 2 9
46 HP:0000660 Lipemia retinalis 1.451E-4 2.388E-3 1.721E-2
1.098E-1
 2 9
47 HP:0005344 Abnormal carotid artery morphology 2.218E-4 3.572E-3 2.575E-2
1.679E-1
 3 60
48 HP:0100546 Carotid artery stenosis 3.130E-4 4.936E-3 3.558E-2
2.369E-1
 2 13
49 HP:0004943 Accelerated atherosclerosis 3.647E-4 5.635E-3 4.061E-2
2.761E-1
 2 14
50 HP:0004929 Coronary atherosclerosis 4.204E-4 6.364E-3 4.587E-2
3.182E-1
 2 15
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 10 input genes in category / 787 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000184 abnormal circulating HDL cholesterol level 1.187E-16 9.340E-14 6.768E-13 9.340E-14 10 269
2 MP:0000186 decreased circulating HDL cholesterol level 4.433E-16 1.745E-13 1.264E-12 3.489E-13 9 162
3 MP:0003982 increased cholesterol level 1.717E-15 2.318E-13 1.680E-12 1.351E-12 10 350
4 MP:0012226 increased sterol level 1.717E-15 2.318E-13 1.680E-12 1.351E-12 10 350
5 MP:0010329 abnormal lipoprotein level 1.767E-15 2.318E-13 1.680E-12 1.391E-12 10 351
6 MP:0010330 abnormal circulating lipoprotein level 1.767E-15 2.318E-13 1.680E-12 1.391E-12 10 351
7 MP:0006084 abnormal circulating phospholipid level 9.116E-15 1.025E-12 7.426E-12 7.174E-12 6 22
8 MP:0000181 abnormal circulating LDL cholesterol level 1.136E-13 1.117E-11 8.097E-11 8.939E-11 8 159
9 MP:0005178 increased circulating cholesterol level 1.583E-13 1.384E-11 1.003E-10 1.246E-10 9 308
10 MP:0020151 abnormal circulating non-HDL cholesterol level 2.480E-13 1.952E-11 1.414E-10 1.952E-10 8 175
11 MP:0005179 decreased circulating cholesterol level 4.320E-13 3.091E-11 2.240E-10 3.400E-10 9 344
12 MP:0001552 increased circulating triglyceride level 6.761E-13 4.434E-11 3.213E-10 5.321E-10 8 198
13 MP:0012225 decreased sterol level 9.223E-13 5.185E-11 3.757E-10 7.258E-10 9 374
14 MP:0003983 decreased cholesterol level 9.223E-13 5.185E-11 3.757E-10 7.258E-10 9 374
15 MP:0001556 increased circulating HDL cholesterol level 4.860E-12 2.550E-10 1.848E-9 3.825E-9 7 130
16 MP:0004777 abnormal phospholipid level 1.317E-11 6.458E-10 4.680E-9 1.036E-8 6 68
17 MP:0005317 increased triglyceride level 1.395E-11 6.458E-10 4.680E-9 1.098E-8 8 288
18 MP:0011969 abnormal circulating triglyceride level 2.664E-10 1.165E-8 8.440E-8 2.097E-7 8 416
19 MP:0003975 increased circulating VLDL triglyceride level 4.370E-10 1.810E-8 1.312E-7 3.439E-7 4 14
20 MP:0005144 abnormal circulating VLDL cholesterol level 9.514E-10 3.744E-8 2.713E-7 7.487E-7 5 56
21 MP:0003192 increased cholesterol efflux 2.593E-9 9.719E-8 7.042E-7 2.041E-6 3 4
22 MP:0000182 increased circulating LDL cholesterol level 3.715E-9 1.329E-7 9.631E-7 2.924E-6 5 73
23 MP:0000183 decreased circulating LDL cholesterol level 1.346E-8 4.469E-7 3.238E-6 1.060E-5 5 94
24 MP:0005145 increased circulating VLDL cholesterol level 1.363E-8 4.469E-7 3.238E-6 1.073E-5 4 31
25 MP:0003980 increased circulating phospholipid level 1.421E-7 4.472E-6 3.240E-5 1.118E-4 3 12
26 MP:0004883 abnormal vascular wound healing 3.467E-7 1.050E-5 7.605E-5 2.729E-4 4 68
27 MP:0005340 altered susceptibility to atherosclerosis 5.442E-7 1.586E-5 1.149E-4 4.283E-4 4 76
28 MP:0003191 abnormal cellular cholesterol metabolism 8.549E-7 2.403E-5 1.741E-4 6.728E-4 3 21
29 MP:0005338 atherosclerotic lesions 2.000E-6 5.429E-5 3.934E-4 1.574E-3 4 105
30 MP:0005339 increased susceptibility to atherosclerosis 2.098E-6 5.504E-5 3.988E-4 1.651E-3 3 28
31 MP:0003991 arteriosclerosis 2.410E-6 6.119E-5 4.434E-4 1.897E-3 4 110
32 MP:0005146 decreased circulating VLDL cholesterol level 2.598E-6 6.389E-5 4.629E-4 2.044E-3 3 30
33 MP:0013245 abnormal lipid metabolism 4.554E-6 1.086E-4 7.870E-4 3.584E-3 3 36
34 MP:0006134 artery occlusion 8.381E-6 1.832E-4 1.328E-3 6.596E-3 2 5
35 MP:0008389 hypochromic macrocytic anemia 8.381E-6 1.832E-4 1.328E-3 6.596E-3 2 5
36 MP:0004254 cerebral amyloid angiopathy 8.381E-6 1.832E-4 1.328E-3 6.596E-3 2 5
37 MP:0005341 decreased susceptibility to atherosclerosis 1.097E-5 2.332E-4 1.690E-3 8.630E-3 3 48
38 MP:0003692 xanthoma 1.257E-5 2.602E-4 1.886E-3 9.889E-3 2 6
39 MP:0003981 decreased circulating phospholipid level 1.758E-5 3.548E-4 2.571E-3 1.384E-2 2 7
40 MP:0000249 abnormal blood vessel physiology 2.308E-5 4.498E-4 3.259E-3 1.817E-2 5 421
41 MP:0000256 echinocytosis 2.343E-5 4.498E-4 3.259E-3 1.844E-2 2 8
42 MP:0005023 abnormal wound healing 2.745E-5 5.144E-4 3.728E-3 2.161E-2 4 203
43 MP:0020408 altered susceptibility to induced thrombosis 3.011E-5 5.511E-4 3.993E-3 2.370E-2 2 9
44 MP:0000604 amyloidosis 3.432E-5 6.138E-4 4.448E-3 2.701E-2 3 70
45 MP:0011951 increased cardiac stroke volume 3.762E-5 6.168E-4 4.469E-3 2.961E-2 2 10
46 MP:0010161 decreased brain cholesterol level 3.762E-5 6.168E-4 4.469E-3 2.961E-2 2 10
47 MP:0012227 decreased brain sterol level 3.762E-5 6.168E-4 4.469E-3 2.961E-2 2 10
48 MP:0003394 increased cardiac output 3.762E-5 6.168E-4 4.469E-3 2.961E-2 2 10
49 MP:0003193 decreased cholesterol efflux 4.596E-5 7.381E-4 5.348E-3 3.617E-2 2 11
50 MP:0012779 abnormal brain cholesterol level 7.592E-5 1.195E-3 8.659E-3
5.975E-2
 2 14
Show 45 more annotations

6: Domain [Display Chart] 14 input genes in category / 89 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PF01442 Apolipoprotein Pfam 1.555E-6 6.920E-5 3.509E-4 1.384E-4 2 3
2 IPR000074 ApoA E InterPro 1.555E-6 6.920E-5 3.509E-4 1.384E-4 2 3
3 IPR033906 Lipase N InterPro 2.325E-5 2.957E-4 1.499E-3 2.070E-3 2 10
4 PF00151 Lipase Pfam 2.325E-5 2.957E-4 1.499E-3 2.070E-3 2 10
5 IPR016272 Lipase LIPH InterPro 2.325E-5 2.957E-4 1.499E-3 2.070E-3 2 10
6 IPR000734 TAG lipase InterPro 2.325E-5 2.957E-4 1.499E-3 2.070E-3 2 10
7 IPR013818 Lipase/vitellogenin InterPro 2.325E-5 2.957E-4 1.499E-3 2.070E-3 2 10
8 SM00308 LH2 SMART 7.880E-5 8.011E-4 4.063E-3 7.013E-3 2 18
9 PS50095 PLAT PROSITE 1.080E-4 8.011E-4 4.063E-3 9.613E-3 2 21
10 IPR001024 PLAT/LH2 dom InterPro 1.080E-4 8.011E-4 4.063E-3 9.613E-3 2 21
11 PF01477 PLAT Pfam 1.080E-4 8.011E-4 4.063E-3 9.613E-3 2 21
12 2.60.60.20 - Gene3D 1.080E-4 8.011E-4 4.063E-3 9.613E-3 2 21
13 PS00120 LIPASE SER PROSITE 1.668E-4 1.142E-3 5.792E-3 1.485E-2 2 26
14 IPR002333 Lipase hep InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
15 IPR023121 ApoC-II domain InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
16 PD010397 ApoA-II ProDom 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
17 1.10.1440.10 - Gene3D 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
18 PD010414 Apo-CIII ProDom 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
19 IPR009454 Lipid transpt open b-sht InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
20 IPR015818 Vitellinogen open b-sht sub2 InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
21 PF05778 Apo-CIII Pfam 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
22 IPR015817 Vitellinogen open b-sht sub1 InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
23 PF09172 DUF1943 Pfam 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
24 IPR006801 ApoA-II InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
25 IPR030365 ABCA1 InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
26 IPR017130 Cholesteryl ester transfer InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
27 2.20.80.10 - Gene3D 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
28 IPR008403 Apo-CIII InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
29 IPR015255 Vitellinogen open b-sht InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
30 IPR006781 ApoC-I InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
31 PF12491 ApoB100 C Pfam 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
32 IPR022176 ApoB100 C InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
33 PF06448 DUF1081 Pfam 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
34 SM01169 DUF1943 SMART 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
35 IPR008019 Apo-CII InterPro 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
36 PF05355 Apo-CII Pfam 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
37 2.20.50.20 - Gene3D 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
38 PF04691 ApoC-I Pfam 7.473E-4 1.750E-3 8.876E-3
6.651E-2
 1 1
39 PS51211 VITELLOGENIN PROSITE 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
40 PF08391 Ly49 Pfam 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
41 IPR015819 Lipid transp b-sht shell InterPro 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
42 IPR002330 Lipo Lipase InterPro 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
43 IPR001747 Lipid transpt N InterPro 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
44 2.30.230.10 - Gene3D 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
45 SM00638 LPD N SMART 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
46 1.25.10.20 - Gene3D 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
47 IPR013600 Ly49 N InterPro 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
48 IPR015816 Vitellinogen b-sht N InterPro 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
49 IPR005428 CD36/SCARB1/SNMP1 InterPro 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
50 PF01347 Vitellogenin N Pfam 1.494E-3 2.659E-3 1.349E-2
1.330E-1
 1 2
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 69 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000482 lipoprotein metabolic Pathway Ontology 3.327E-30 2.296E-28 1.106E-27 2.296E-28 10 13
2 1270005 Lipoprotein metabolism BioSystems: REACTOME 9.860E-27 3.402E-25 1.639E-24 6.803E-25 12 74
3 1270002 Lipid digestion, mobilization, and transport BioSystems: REACTOME 2.762E-24 6.353E-23 3.061E-22 1.906E-22 12 115
4 1270006 Chylomicron-mediated lipid transport BioSystems: REACTOME 2.780E-19 4.796E-18 2.311E-17 1.918E-17 8 28
5 PW:0000484 altered lipoprotein metabolic Pathway Ontology 2.324E-18 3.207E-17 1.545E-16 1.604E-16 6 7
6 1270007 HDL-mediated lipid transport BioSystems: REACTOME 1.441E-17 1.657E-16 7.983E-16 9.940E-16 7 20
7 1269624 Retinoid metabolism and transport BioSystems: REACTOME 7.049E-15 6.948E-14 3.348E-13 4.864E-13 7 44
8 1339147 Metabolism of fat-soluble vitamins BioSystems: REACTOME 2.825E-14 2.436E-13 1.174E-12 1.949E-12 7 53
9 PW:0000498 reverse cholesterol transport Pathway Ontology 1.299E-13 9.956E-13 4.798E-12 8.961E-12 5 10
10 1269623 Visual phototransduction BioSystems: REACTOME 3.088E-12 2.131E-11 1.027E-10 2.131E-10 7 101
11 1270144 Metabolism of vitamins and cofactors BioSystems: REACTOME 1.665E-10 1.044E-9 5.032E-9 1.149E-8 7 177
12 83042 PPAR signaling pathway BioSystems: KEGG 6.974E-9 4.010E-8 1.932E-7 4.812E-7 5 72
13 1269900 Scavenging by Class B Receptors BioSystems: REACTOME 8.884E-9 4.715E-8 2.272E-7 6.130E-7 3 5
14 194385 Fat digestion and absorption BioSystems: KEGG 7.083E-8 3.491E-7 1.682E-6 4.887E-6 4 41
15 1269897 Binding and Uptake of Ligands by Scavenger Receptors BioSystems: REACTOME 1.475E-7 6.785E-7 3.270E-6 1.018E-5 4 49
16 1269899 Scavenging by Class A Receptors BioSystems: REACTOME 1.170E-6 5.046E-6 2.432E-5 8.074E-5 3 21
17 199556 Vitamin digestion and absorption BioSystems: KEGG 1.778E-6 7.215E-6 3.477E-5 1.227E-4 3 24
18 1427852 VLDL biosynthesis BioSystems: REACTOME 1.005E-5 3.851E-5 1.856E-4 6.933E-4 2 5
19 M2404 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) MSigDB C2 BIOCARTA (v6.0) 2.655E-5 9.641E-5 4.646E-4 1.832E-3 3 58
20 SMP00039 Glycerolipid Metabolism SMPDB 6.604E-5 2.278E-4 1.098E-3 4.557E-3 2 12
21 1427851 VLDL interactions BioSystems: REACTOME 2.515E-4 7.594E-4 3.659E-3 1.735E-2 2 23
22 1270030 PPARA activates gene expression BioSystems: REACTOME 2.564E-4 7.594E-4 3.659E-3 1.769E-2 3 124
23 1270008 LDL-mediated lipid transport BioSystems: REACTOME 2.742E-4 7.594E-4 3.659E-3 1.892E-2 2 24
24 PW:0000015 Alzheimer disease Pathway Ontology 2.742E-4 7.594E-4 3.659E-3 1.892E-2 2 24
25 1270029 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) BioSystems: REACTOME 2.751E-4 7.594E-4 3.659E-3 1.898E-2 3 127
26 PW:0000153 glycerolipid metabolic Pathway Ontology 4.307E-4 1.143E-3 5.507E-3 2.972E-2 2 30
27 PW:0000544 altered reverse cholesterol transport Pathway Ontology 1.044E-3 2.611E-3 1.258E-2
7.205E-2
 1 1
28 MAP00561 Glycerolipid metabolism MAP00561 Glycerolipid metabolism GenMAPP 1.060E-3 2.611E-3 1.258E-2
7.311E-2
 2 47
29 82986 Glycerolipid metabolism BioSystems: KEGG 1.665E-3 3.962E-3 1.909E-2
1.149E-1
 2 59
30 1270010 Fatty acid, triacylglycerol, and ketone body metabolism BioSystems: REACTOME 2.040E-3 4.691E-3 2.260E-2
1.407E-1
 3 253
31 PW:0000010 lipid metabolic Pathway Ontology 4.171E-3 8.993E-3 4.333E-2
2.878E-1
 1 4
32 1269902 Scavenging by Class H Receptors BioSystems: REACTOME 4.171E-3 8.993E-3 4.333E-2
2.878E-1
 1 4
33 P05726 2-arachidonoylglycerol biosynthesis PantherDB 6.250E-3 1.268E-2
6.112E-2
4.312E-1
 1 6
34 1269901 Scavenging by Class F Receptors BioSystems: REACTOME 6.250E-3 1.268E-2
6.112E-2
4.312E-1
 1 6
35 SMP00383 Obesity / Metabolic Syndrome SMPDB 9.361E-3 1.803E-2
8.686E-2
6.459E-1
 1 9
36 1269373 Cell surface interactions at the vascular wall BioSystems: REACTOME 9.405E-3 1.803E-2
8.686E-2
6.490E-1
 2 143
37 PW:0000244 Angiotensin II signaling Pathway Ontology 1.040E-2 1.939E-2
9.342E-2
7.174E-1
 1 10
38 153910 Phagosome BioSystems: KEGG 1.084E-2 1.969E-2
9.487E-2
7.482E-1
 2 154
39 142418 triacylglycerol degradation BioSystems: BIOCYC 1.143E-2 1.972E-2
9.501E-2
7.887E-1
 1 11
40 413388 Acylglycerol degradation BioSystems: KEGG 1.143E-2 1.972E-2
9.501E-2
7.887E-1
 1 11
41 83097 Alzheimer's disease BioSystems: KEGG 1.324E-2 2.229E-2
1.074E-1
9.139E-1
 2 171
42 137975 RXR and RAR heterodimerization with other nuclear receptor BioSystems: Pathway Interaction Database 1.453E-2 2.387E-2
1.150E-1
1.000E0
 1 14
43 1427857 Regulation of TLR by endogenous ligand BioSystems: REACTOME 1.659E-2 2.642E-2
1.273E-1
1.000E0
 1 16
44 1269348 Platelet sensitization by LDL BioSystems: REACTOME 1.761E-2 2.642E-2
1.273E-1
1.000E0
 1 17
45 545293 retinol biosynthesis BioSystems: BIOCYC 1.761E-2 2.642E-2
1.273E-1
1.000E0
 1 17
46 1270003 Digestion of dietary lipid BioSystems: REACTOME 1.761E-2 2.642E-2
1.273E-1
1.000E0
 1 17
47 1269905 ABC transporters in lipid homeostasis BioSystems: REACTOME 1.864E-2 2.737E-2
1.319E-1
1.000E0
 1 18
48 1269898 Scavenging of heme from plasma BioSystems: REACTOME 1.967E-2 2.827E-2
1.362E-1
1.000E0
 1 19
Show 43 more annotations

8: Pubmed [Display Chart] 14 input genes in category / 11902 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20031551 Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response. Pubmed 4.877E-33 5.805E-29 5.783E-28 5.805E-29 11 31
2 17855807 Maternal and fetal variation in genes of cholesterol metabolism is associated with preterm delivery. Pubmed 4.807E-29 2.858E-25 2.847E-24 5.721E-25 9 16
3 18193044 Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. Pubmed 7.204E-29 2.858E-25 2.847E-24 8.574E-25 10 34
4 20430392 No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels. Pubmed 3.880E-28 1.155E-24 1.150E-23 4.618E-24 9 19
5 20864672 Genetic variants influencing circulating lipid levels and risk of coronary artery disease. Pubmed 4.508E-27 1.073E-23 1.069E-22 5.366E-23 10 49
6 19060906 Common variants at 30 loci contribute to polygenic dyslipidemia. Pubmed 1.604E-26 3.181E-23 3.169E-22 1.909E-22 10 55
7 20855565 Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease. Pubmed 3.443E-26 5.855E-23 5.833E-22 4.098E-22 10 59
8 16763159 Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants. Pubmed 1.720E-25 2.560E-22 2.550E-21 2.048E-21 8 15
9 18193043 Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Pubmed 3.946E-25 5.219E-22 5.199E-21 4.697E-21 9 36
10 20686565 Biological, clinical and population relevance of 95 loci for blood lipids. Pubmed 6.755E-25 8.040E-22 8.009E-21 8.040E-21 11 147
11 16542392 Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels. Pubmed 1.168E-24 1.264E-21 1.259E-20 1.390E-20 7 8
12 19878569 Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. Pubmed 1.468E-24 1.456E-21 1.450E-20 1.747E-20 9 41
13 20714348 Common inherited variation in mitochondrial genes is not enriched for associations with type 2 diabetes or related glycemic traits. Pubmed 3.366E-24 3.081E-21 3.070E-20 4.006E-20 8 20
14 11162594 Apolipoprotein specificity for lipid efflux by the human ABCAI transporter. Pubmed 5.254E-24 4.467E-21 4.450E-20 6.253E-20 7 9
15 22286219 Genome-wide association study identifies multiple loci influencing human serum metabolite levels. Pubmed 5.705E-24 4.526E-21 4.509E-20 6.790E-20 9 47
16 16770077 Concordant association of lipid gene variation with a combined HDL/LDL-cholesterol phenotype in two European populations. Pubmed 1.751E-23 1.226E-20 1.221E-19 2.084E-19 7 10
17 12966036 Association of extreme blood lipid profile phenotypic variation with 11 reverse cholesterol transport genes and 10 non-genetic cardiovascular disease risk factors. Pubmed 1.751E-23 1.226E-20 1.221E-19 2.084E-19 7 10
18 19689828 Nutrigenetics: links between genetic background and response to Mediterranean-type diets. Pubmed 4.815E-23 3.184E-20 3.171E-19 5.730E-19 7 11
19 22916037 Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis. Pubmed 8.478E-23 5.311E-20 5.290E-19 1.009E-18 9 62
20 19948975 Integrative predictive model of coronary artery calcification in atherosclerosis. Pubmed 1.012E-22 6.024E-20 6.001E-19 1.205E-18 11 229
21 20167577 Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2 with dementia risk. Pubmed 1.145E-22 6.491E-20 6.466E-19 1.363E-18 8 29
22 17700364 Contribution of 20 single nucleotide polymorphisms of 13 genes to dyslipidemia associated with antiretroviral therapy. Pubmed 2.503E-22 1.354E-19 1.349E-18 2.979E-18 7 13
23 18660489 Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. Pubmed 2.709E-22 1.402E-19 1.397E-18 3.224E-18 11 250
24 19060911 Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts. Pubmed 6.275E-22 3.072E-19 3.060E-18 7.469E-18 8 35
25 15657615 Polymorphisms in APOA1 and LPL genes are statistically independently associated with fasting TG in men with CAD. Pubmed 6.969E-22 3.072E-19 3.060E-18 8.294E-18 6 6
26 11171287 Common genetic variants that relate to disorders of lipid transport in Spanish subjects with premature coronary artery disease. Pubmed 6.969E-22 3.072E-19 3.060E-18 8.294E-18 6 6
27 12964943 Genetic study of common variants at the Apo E, Apo AI, Apo CIII, Apo B, lipoprotein lipase (LPL) and hepatic lipase (LIPC) genes and coronary artery disease (CAD): variation in LIPC gene associates with clinical outcomes in patients with established CAD. Pubmed 6.969E-22 3.072E-19 3.060E-18 8.294E-18 6 6
28 4345202 Interchange of apolipoproteins between chylomicrons and high density lipoproteins during alimentary lipemia in man. Pubmed 4.877E-21 2.073E-18 2.065E-17 5.805E-17 6 7
29 16498401 In vivo role of the HNF4alpha AF-1 activation domain revealed by exon swapping. Pubmed 5.739E-21 2.355E-18 2.346E-17 6.831E-17 8 45
30 20602615 Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? Pubmed 8.000E-21 3.174E-18 3.162E-17 9.521E-17 10 192
31 23631828 Identification of potential bladder cancer markers in urine by abundant-protein depletion coupled with quantitative proteomics. Pubmed 1.951E-20 7.489E-18 7.460E-17 2.322E-16 6 8
32 21943158 Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. Pubmed 2.484E-20 9.238E-18 9.203E-17 2.956E-16 7 22
33 19773416 A gene score of nine LDL and HDL regulating genes is associated with fluvastatin-induced cholesterol changes in women. Pubmed 5.851E-20 1.934E-17 1.927E-16 6.963E-16 6 9
34 12116231 Candidate genes involved in cardiovascular risk factors by a family-based association study on the island of Kosrae, Federated States of Micronesia. Pubmed 5.851E-20 1.934E-17 1.927E-16 6.963E-16 6 9
35 16030523 Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. Pubmed 5.851E-20 1.934E-17 1.927E-16 6.963E-16 6 9
36 18354102 Polymorphisms associated with cholesterol and risk of cardiovascular events. Pubmed 5.851E-20 1.934E-17 1.927E-16 6.963E-16 6 9
37 19336370 Determination of genetic predisposition to patent ductus arteriosus in preterm infants. Pubmed 9.127E-20 2.936E-17 2.925E-16 1.086E-15 9 130
38 19336475 Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk. Pubmed 4.999E-19 1.566E-16 1.560E-15 5.949E-15 8 76
39 19155782 The environmental and genetic evidence for the association of hyperlipidemia and hypertension. Pubmed 1.194E-18 3.645E-16 3.631E-15 1.422E-14 6 13
40 182536 Effect of serum and C-apoproteins from very low density lipoproteins on human postheparin plasma hepatic lipase. Pubmed 2.957E-18 7.998E-16 7.968E-15 3.519E-14 5 5
41 12782148 Effects of plasma apolipoproteins on lipoprotein lipase-mediated lipolysis of small and large lipid emulsions. Pubmed 2.957E-18 7.998E-16 7.968E-15 3.519E-14 5 5
42 8245722 Identification of disulfide-linked apolipoprotein species in human lipoproteins. Pubmed 2.957E-18 7.998E-16 7.968E-15 3.519E-14 5 5
43 18187430 The lipoprotein lipase serine 447 stop polymorphism is associated with altered serum carotenoid concentrations in the Stanislas Family Study. Pubmed 2.957E-18 7.998E-16 7.968E-15 3.519E-14 5 5
44 1917954 Mechanisms of inhibition by apolipoprotein C of apolipoprotein E-dependent cellular metabolism of human triglyceride-rich lipoproteins through the low density lipoprotein receptor pathway. Pubmed 2.957E-18 7.998E-16 7.968E-15 3.519E-14 5 5
45 20691829 Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease. Pubmed 5.571E-18 1.473E-15 1.468E-14 6.630E-14 6 16
46 24097068 Discovery and refinement of loci associated with lipid levels. Pubmed 8.239E-18 2.132E-15 2.124E-14 9.806E-14 9 212
47 18927546 Lp(a) and risk of recurrent cardiac events in obese postinfarction patients. Pubmed 8.608E-18 2.180E-15 2.171E-14 1.024E-13 6 17
48 19489872 Association of polymorphisms in genes involved in lipoprotein metabolism with plasma concentrations of remnant lipoproteins and HDL subpopulations before and after hormone therapy in postmenopausal women. Pubmed 1.774E-17 4.060E-15 4.044E-14 2.111E-13 5 6
49 19534808 Lipoprotein lipase activity and mass, apolipoprotein C-II mass and polymorphisms of apolipoproteins E and A5 in subjects with prior acute hypertriglyceridaemic pancreatitis. Pubmed 1.774E-17 4.060E-15 4.044E-14 2.111E-13 5 6
50 19285487 Genetic determinants of plasma HDL-cholesterol levels in prepubertal children. Pubmed 1.774E-17 4.060E-15 4.044E-14 2.111E-13 5 6
Show 45 more annotations

9: Interaction [Display Chart] 14 input genes in category / 688 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:APOA1 APOA1 interactions 6.558E-18 4.512E-15 3.209E-14 4.512E-15 9 98
2 int:APOA2 APOA2 interactions 1.453E-9 4.999E-7 3.555E-6 9.998E-7 4 21
3 int:ALB ALB interactions 7.618E-9 1.222E-6 8.689E-6 5.241E-6 6 212
4 int:APOC1 APOC1 interactions 7.863E-9 1.222E-6 8.689E-6 5.410E-6 3 6
5 int:SCARB1 SCARB1 interactions 1.263E-8 1.222E-6 8.689E-6 8.692E-6 4 35
6 int:LCAT LCAT interactions 1.375E-8 1.222E-6 8.689E-6 9.463E-6 3 7
7 int:CETP CETP interactions 1.375E-8 1.222E-6 8.689E-6 9.463E-6 3 7
8 int:PLTP PLTP interactions 1.421E-8 1.222E-6 8.689E-6 9.774E-6 4 36
9 int:LPL LPL interactions 5.193E-7 3.970E-5 2.823E-4 3.573E-4 3 21
10 int:VKORC1 VKORC1 interactions 7.797E-7 5.364E-5 3.815E-4 5.364E-4 4 96
11 int:APOF APOF interactions 3.481E-6 1.996E-4 1.420E-3 2.395E-3 2 4
12 int:APOC2 APOC2 interactions 3.481E-6 1.996E-4 1.420E-3 2.395E-3 2 4
13 int:APOC3 APOC3 interactions 8.696E-6 4.602E-4 3.273E-3 5.983E-3 2 6
14 int:ABCA13 ABCA13 interactions 1.622E-5 7.970E-4 5.668E-3 1.116E-2 2 8
15 int:APOB APOB interactions 1.749E-5 8.024E-4 5.707E-3 1.204E-2 3 66
16 int:ARFGAP1 ARFGAP1 interactions 2.180E-5 9.374E-4 6.667E-3 1.500E-2 3 71
17 int:ZNF558 ZNF558 interactions 2.604E-5 1.054E-3 7.495E-3 1.792E-2 2 10
18 int:LRP2 LRP2 interactions 2.782E-5 1.063E-3 7.563E-3 1.914E-2 3 77
19 int:CD81 CD81 interactions 3.062E-5 1.109E-3 7.884E-3 2.106E-2 4 242
20 int:APOE APOE interactions 3.485E-5 1.199E-3 8.526E-3 2.398E-2 3 83
21 int:DGAT1 DGAT1 interactions 3.816E-5 1.250E-3 8.891E-3 2.625E-2 2 12
22 int:VLDLR VLDLR interactions 7.845E-5 2.453E-3 1.745E-2
5.397E-2
 2 17
23 int:LMF1 LMF1 interactions 1.095E-4 3.274E-3 2.328E-2
7.530E-2
 2 20
24 int:NAXE NAXE interactions 1.209E-4 3.466E-3 2.465E-2
8.319E-2
 2 21
25 int:LRP1 LRP1 interactions 1.584E-4 4.360E-3 3.101E-2
1.090E-1
 3 138
26 int:CALR CALR interactions 2.107E-4 5.577E-3 3.966E-2
1.450E-1
 3 152
27 int:GDPD1 GDPD1 interactions 2.329E-4 5.935E-3 4.221E-2
1.603E-1
 2 29
28 int:HBA1 HBA1 interactions 2.842E-4 6.983E-3 4.966E-2
1.955E-1
 2 32
29 int:LIPC LIPC interactions 3.603E-4 8.548E-3
6.079E-2
2.479E-1
 2 36
30 int:LDLR LDLR interactions 4.679E-4 1.073E-2
7.631E-2
3.219E-1
 2 41
31 int:APOD APOD interactions 5.639E-4 1.251E-2
8.900E-2
3.880E-1
 2 45
32 int:ABCA1 ABCA1 interactions 6.962E-4 1.497E-2
1.064E-1
4.790E-1
 2 50
33 int:PDZK1 PDZK1 interactions 9.042E-4 1.885E-2
1.341E-1
6.221E-1
 2 57
34 int:AKT2 AKT2 interactions 1.518E-3 2.863E-2
2.036E-1
1.000E0
 2 74
35 int:ERVK-10 ERVK-10 interactions 1.581E-3 2.863E-2
2.036E-1
1.000E0
 1 2
36 int:SYT8 SYT8 interactions 1.581E-3 2.863E-2
2.036E-1
1.000E0
 1 2
37 int:FAM83C FAM83C interactions 1.581E-3 2.863E-2
2.036E-1
1.000E0
 1 2
38 int:TXNDC2 TXNDC2 interactions 1.581E-3 2.863E-2
2.036E-1
1.000E0
 1 2
39 int:ATP4A ATP4A interactions 2.285E-3 3.546E-2
2.522E-1
1.000E0
 2 91
40 int:RPL13AP17 RPL13AP17 interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
41 int:SAA2 SAA2 interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
42 int:ADHFE1 ADHFE1 interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
43 int:APOL1 APOL1 interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
44 int:ABCA6 ABCA6 interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
45 int:SMPDL3A SMPDL3A interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
46 int:SPEF2 SPEF2 interactions 2.371E-3 3.546E-2
2.522E-1
1.000E0
 1 3
47 int:HLA-DPA1 HLA-DPA1 interactions 2.486E-3 3.640E-2
2.588E-1
1.000E0
 2 95
48 int:CEL CEL interactions 3.160E-3 4.348E-2
3.092E-1
1.000E0
 1 4
49 int:P2RY14 P2RY14 interactions 3.160E-3 4.348E-2
3.092E-1
1.000E0
 1 4
50 int:CKLF CKLF interactions 3.160E-3 4.348E-2
3.092E-1
1.000E0
 1 4
Show 45 more annotations

10: Cytoband [Display Chart] 14 input genes in category / 12 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19q13.2 19q13.2 3.984E-5 4.781E-4 1.484E-3 4.781E-4 3 169
2 15q21-q23 15q21-q23 4.039E-4 2.423E-3 7.521E-3 4.847E-3 1 1
3 2p24-p23 2p24-p23 8.077E-4 3.231E-3 1.003E-2 9.692E-3 1 2
4 11q23-q24 11q23-q24 1.211E-3 3.634E-3 1.128E-2 1.454E-2 1 3
5 12p13.2-p12.3 12p13.2-p12.3 1.615E-3 3.875E-3 1.203E-2 1.938E-2 1 4
6 6q14-q15 6q14-q15 2.824E-3 5.648E-3 1.753E-2 3.389E-2 1 7
7 8p22 8p22 1.644E-2 2.449E-2
7.599E-2
1.972E-1
 1 41
8 9q31.1 9q31.1 1.683E-2 2.449E-2
7.599E-2
2.020E-1
 1 42
9 16q21 16q21 1.842E-2 2.449E-2
7.599E-2
2.211E-1
 1 46
10 1q23.3 1q23.3 2.041E-2 2.449E-2
7.599E-2
2.449E-1
 1 51
11 12q24.31 12q24.31 3.223E-2 3.301E-2
1.024E-1
3.868E-1
 1 81
12 11q23.3 11q23.3 3.301E-2 3.301E-2
1.024E-1
3.962E-1
 1 83
Show 7 more annotations

11: Transcription Factor Binding Site [Display Chart] 10 input genes in category / 123 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 14 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 405 Apolipoproteins genenames.org 3.037E-18 2.126E-17 5.512E-17 2.126E-17 7 21
2 464 Lipases genenames.org 1.259E-4 4.407E-4 1.143E-3 8.813E-4 2 22
3 1253 Scavenger receptors genenames.org 1.909E-4 4.454E-4 1.155E-3 1.336E-3 2 27
4 805 ATP binding cassette subfamily A genenames.org 1.072E-2 1.714E-2 4.445E-2
7.506E-2
 1 14
5 456 BPI fold containing genenames.org 1.225E-2 1.714E-2 4.445E-2
8.572E-2
 1 16
6 494 C-type lectin domain family genenames.org 3.558E-2 4.151E-2
1.076E-1
2.490E-1
 1 47
Show 1 more annotation

13: Coexpression [Display Chart] 14 input genes in category / 1590 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18318837-Table1 Human MesenchymalStemCells Yamamoto08 83genes GeneSigDB 3.789E-17 6.024E-14 4.788E-13 6.024E-14 8 79
2 M13283 Liver selective genes MSigDB C2: CGP Curated Gene Sets (v6.0) 3.878E-13 3.083E-10 2.451E-9 6.167E-10 8 244
3 11834723-Table1a Human Viral Naiki02 56genes GeneSigDB 1.024E-10 5.428E-8 4.315E-7 1.628E-7 5 53
4 M5946 Genes encoding components of blood coagulation system; also up-regulated in platelets. MSigDB H: Hallmark Gene Sets (v6.0) 1.346E-8 5.349E-6 4.252E-5 2.140E-5 5 138
5 M1678 Strongly up-regulated at 96 h during differentiation of 3T3-L1 cells (fibroblast) into adipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.506E-8 2.069E-5 1.644E-4 1.034E-4 5 189
6 M2301 Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout and in normal 8.5 dpc embryos compared to normal 9.5 dpc embryos. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.699E-7 4.503E-5 3.579E-4 2.702E-4 3 19
7 M4562 Genes up-regulated during in vitro maturation of CD14+ [GeneID=929] monocytes (day 0) into immature (day 7) and mature dendritic cells (day 14). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.386E-7 1.223E-4 9.726E-4 8.564E-4 4 114
8 16423883-Table3 Mouse Liver Jeong06 39genes GeneSigDB 9.520E-7 1.892E-4 1.504E-3 1.514E-3 3 33
9 16110340-Table2 Mouse Liver Le05 53genes GeneSigDB 2.815E-6 4.973E-4 3.953E-3 4.476E-3 3 47
10 M1806 Direct targets of FOXA2 [GeneID=3170] in liver, according to a ChIP-chip analysis. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.567E-6 5.372E-4 4.270E-3 5.672E-3 5 425
11 M2768 Genes up-regulated during late stages of differentiation of embryoid bodies from J1 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 4.223E-6 5.372E-4 4.270E-3 6.714E-3 4 191
12 18310505-Table1 Human StemCell Matushansky08 69genes GeneSigDB 4.542E-6 5.372E-4 4.270E-3 7.221E-3 3 55
13 M9677 Genes down-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 20h. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-6 5.372E-4 4.270E-3 8.058E-3 4 200
14 M5905 Genes up-regulated during adipocyte differentiation (adipogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 5.068E-6 5.372E-4 4.270E-3 8.058E-3 4 200
15 M9535 Genes down-regulated in skin: uninfected versus S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 5.068E-6 5.372E-4 4.270E-3 8.058E-3 4 200
16 16440291-SuppTable1 Human HeadandNeck Martens06 209genes GeneSigDB 5.697E-6 5.662E-4 4.500E-3 9.058E-3 4 206
17 16423883-Table2S Mouse Liver Jeong06 492genes GeneSigDB 7.127E-6 6.666E-4 5.299E-3 1.133E-2 4 218
18 M15476 Genes up-regulated in primary adipocytes compared to preadipocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.115E-5 9.846E-4 7.826E-3 1.772E-2 3 74
19 12771952-Table2 Human Liver Iizuka03 89genes GeneSigDB 1.463E-5 1.207E-3 9.595E-3 2.327E-2 3 81
20 15788672-Table1 Human Prostate Gu05 120genes GeneSigDB 1.518E-5 1.207E-3 9.595E-3 2.414E-2 3 82
21 15643601-Table6 Human Pancreas Centeno05 11genes GeneSigDB 1.864E-5 1.404E-3 1.116E-2 2.964E-2 2 11
22 M2299 Genes up-regulated in 9.5 days post coitus (dpc) embryos with COMMD1 [GeneID=150684] knockout compared to normal 9.5 dpc embryos. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.942E-5 1.404E-3 1.116E-2 3.088E-2 3 89
23 M5688 Genes up-regulated in Paneth cell (part of intestiinal epithelium) of mice with hypomorphic (reduced function) form of ATG16L1 [GeneID=55054]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.216E-5 1.532E-3 1.218E-2 3.524E-2 3 93
24 M11028 Genes in the most frequently gained loci in a panel of glioma cell lines. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.755E-5 1.825E-3 1.451E-2 4.380E-2 3 100
25 16373702-Table1a Human Lymphoma Mahadevan05 21genes PTCL-NOSvsNormalPeripheralBloodTCells GeneSigDB 5.780E-5 3.535E-3 2.810E-2
9.190E-2
 2 19
26 16104048-Table3 Mouse Liver Yamamoto05 30genes UpRegulated GeneSigDB 5.780E-5 3.535E-3 2.810E-2
9.190E-2
 2 19
27 M4872 Genes up-regulated in mature plasma cells compared with plasmablastic B lymphocytes. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.458E-5 4.392E-3 3.491E-2
1.186E-1
 4 397
28 11493696-TableS2 Human Kidney Takahashi01 32genes GeneSigDB 8.540E-5 4.849E-3 3.855E-2
1.358E-1
 2 23
29 M3645 Genes up-regulated in papillary thyroid carcinoma (PTC) compared to normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.140E-4 6.249E-3 4.967E-2
1.812E-1
 4 443
30 17786710-Table2 Human Lymphoma Uyttebroeck07 52genes GeneSigDB 1.274E-4 6.731E-3
5.350E-2
2.025E-1
 2 28
31 M7626 Genes up-regulated in CD8 T cells: naïve versus 1' memory. MSigDB C7: Immunologic Signatures (v6.0) 1.337E-4 6.731E-3
5.350E-2
2.125E-1
 3 170
32 M6757 Genes down-regulated in splenic CD 33D1+ dendritic cells versus CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.384E-4 6.731E-3
5.350E-2
2.200E-1
 3 172
33 15845616-SuppTable3 Mouse Uterine Jeong05 634genes GeneSigDB 1.577E-4 6.731E-3
5.350E-2
2.508E-1
 4 482
34 15756019-Table3 Human StemCell Appel05 genes GeneSigDB 1.776E-4 6.731E-3
5.350E-2
2.824E-1
 2 33
35 M1773 Genes up-regulated in neural progenitor cells (NPC) isolated from E13 cortical tissue of SMRT [GeneID=9612] knockout mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.776E-4 6.731E-3
5.350E-2
2.824E-1
 2 33
36 M5319 Genes up-regulated by imatinib [PubChem=5291] during dendritic cell differentiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.776E-4 6.731E-3
5.350E-2
2.824E-1
 2 33
37 M2772 Genes up-regulated during late stages of differentiation of embryoid bodies from V6.5 embryonic stem cells. MSigDB C6: Oncogenic Signatures (v6.0) 1.856E-4 6.731E-3
5.350E-2
2.951E-1
 3 190
38 19808960-Table2 Human Kidney Moore09 38genes GeneSigDB 1.886E-4 6.731E-3
5.350E-2
2.999E-1
 2 34
39 M8736 Genes down-regulated in T cells: control versus IL2 [GeneID=3558] stimulation for 2h. MSigDB C7: Immunologic Signatures (v6.0) 2.096E-4 6.731E-3
5.350E-2
3.333E-1
 3 198
40 M5944 Genes up-regulated during formation of blood vessels (angiogenesis). MSigDB H: Hallmark Gene Sets (v6.0) 2.117E-4 6.731E-3
5.350E-2
3.366E-1
 2 36
41 M13438 Up-regulated genes in the 'Field Effect' signature of normal lung tissue adjacent to the tumor. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.117E-4 6.731E-3
5.350E-2
3.366E-1
 2 36
42 18172294-Table1 Mouse Lung Stearman08 48genes GeneSigDB 2.117E-4 6.731E-3
5.350E-2
3.366E-1
 2 36
43 M9537 Genes up-regulated in skin: wildtype versus IL1R1 [GeneID=3554] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.127E-4 6.731E-3
5.350E-2
3.382E-1
 3 199
44 M8398 Genes down-regulated in brain microglia versus spleen CD8+ dendritic cells. MSigDB C7: Immunologic Signatures (v6.0) 2.127E-4 6.731E-3
5.350E-2
3.382E-1
 3 199
45 M5184 Genes down-regulated in comparison of dendritic cells (DC) exposed to T. gondii versus macrophages exposed to T. gondii. MSigDB C7: Immunologic Signatures (v6.0) 2.127E-4 6.731E-3
5.350E-2
3.382E-1
 3 199
46 M9675 Genes down-regulated in CD4 [GeneID=920] T helper cells Th17 treated with TGFB1 and IL6 [GeneID=7040;3569]: 1h versus 10h. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 6.731E-3
5.350E-2
3.433E-1
 3 200
47 M3096 Genes up-regulated in comparison of healthy myeloid cells versus systemic lupus erythematosus myeloid cells. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 6.731E-3
5.350E-2
3.433E-1
 3 200
48 M8209 Genes up-regulated in germinal center B lymphocytes over-expressing: PRDM1 [GeneID=639] versus Epstein-Barr virus protein LMP1. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 6.731E-3
5.350E-2
3.433E-1
 3 200
49 M5147 Genes up-regulated in untreated dendritic cells (DC) versus DCs exposed to parasite Toxoplasma gondii. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 6.731E-3
5.350E-2
3.433E-1
 3 200
50 M9691 Genes up-regulated in CD4 [GeneID=920] T helper cells (60h): Th0 versus Th17 treated with TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 6.731E-3
5.350E-2
3.433E-1
 3 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 14 input genes in category / 1541 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 liver liver Human Protein Atlas 4.681E-11 6.962E-8 5.512E-7 7.214E-8 8 419
2 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Mature Teratoma, Yolk Sac Tumor/6 Sample Type by Project: Shred 1/TCGA-Testes/Testicular Germ Cell Tumor/Non-Seminoma- Mature Teratoma, Yolk Sac Tumor/6 TCGA-Testes 9.035E-11 6.962E-8 5.512E-7 1.392E-7 6 125
3 PCBC ratio EB-blastocyst vs EB-cbCD34 500 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 PCBC 7.788E-9 3.550E-6 2.811E-5 1.200E-5 7 486
4 PCBC EB blastocyst 500 Progenitor-Cell-Biology-Consortium EmbryoidBody fromBlastocyst-derived-humanEmbryonicStemCells top-relative-expression-ranked 500 PCBC 9.216E-9 3.550E-6 2.811E-5 1.420E-5 7 498
5 ratio EB-blastocyst vs EB-cbCD34 1000 K2 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 1.620E-8 4.992E-6 3.953E-5 2.496E-5 6 296
6 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/1/0 Sample Type by Project: Shred 1/TCGA-Liver/Hepatocellular Carcinoma/Hepatocellular Carcinoma/1/0 TCGA-Liver 2.223E-8 5.711E-6 4.522E-5 3.426E-5 5 144
7 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Liver Tabula Muris Consortium 3.322E-8 7.313E-6 5.791E-5 5.119E-5 5 156
8 ratio EB-fibro vs EB-cbCD34 500 K2 ratio EmbryoidBody-fibro vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 k-means-cluster#2 PCBC 4.013E-8 7.731E-6 6.121E-5 6.185E-5 5 162
9 PCBC ratio MESO-30 from-ESC vs MESO-30 from-plasmid cfr-2X-p05 Mesoderm Day 30-method NA vs Mesoderm Day 30-method plasmid-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 6.602E-8 9.249E-6 7.323E-5 1.017E-4 6 375
10 PCBC ratio MESO-30 blastocyst vs MESO-30 fibroblast cfr-2X-p05 MESO-30 blastocyst vs MESO-30 fibroblast-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 6.602E-8 9.249E-6 7.323E-5 1.017E-4 6 375
11 PCBC ratio MESO-30 from-ESC vs MESO-30 from-OSKM - NLT cfr-2X-p05 Mesoderm Day 30-reprogram NA vs Mesoderm Day 30-reprogram OSKM - NLT-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 6.602E-8 9.249E-6 7.323E-5 1.017E-4 6 375
12 PCBC ratio EB blastocyst vs EB UCB CD34+Z cfr-2X-p05 EB blastocyst vs EB UCB CD34+Z-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 7.927E-8 1.018E-5 8.060E-5 1.222E-4 4 67
13 gudmap developingKidney e15.5 early proxim tubul 1000 k1 DevelopingKidney e15.5 early proxim tubul emap-28005 k-means-cluster#1 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 9.380E-8 1.060E-5 8.389E-5 1.445E-4 5 192
14 ratio EB-blastocyst vs EB-cbCD34 500 K1 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 k-means-cluster#1 PCBC 9.626E-8 1.060E-5 8.389E-5 1.483E-4 5 193
15 ratio EB vs SC 1000 K5 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 1.254E-7 1.207E-5 9.560E-5 1.933E-4 6 418
16 ratio EB vs SC 500 K3 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 k-means-cluster#3 PCBC 1.269E-7 1.207E-5 9.560E-5 1.955E-4 5 204
17 Facebase ST1 Univ 250 UniversalReference WholeMouseP1 top-relative-expression-ranked 250 FaceBase_ST1 1.332E-7 1.207E-5 9.560E-5 2.053E-4 5 206
18 gudmap developingKidney e15.5 early proxim tubul 500 k3 DevelopingKidney e15.5 early proxim tubul emap-28005 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.547E-7 1.324E-5 1.049E-4 2.384E-4 4 79
19 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5 Sample Type by Project: Shred 1/TCGA-Bile Duct/Cholangiocarcinoma/Intrahepatic/5 TCGA-Bile Duct 2.740E-7 2.222E-5 1.759E-4 4.222E-4 4 91
20 PCBC ratio EB-fibro vs EB-cbCD34 500 ratio EmbryoidBody-fibro vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 500 PCBC 3.395E-7 2.615E-5 2.071E-4 5.231E-4 6 495
21 Arv EB-LF 500 K2 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 k-means-cluster#2 PCBC 3.918E-7 2.684E-5 2.125E-4 6.037E-4 5 256
22 PCBC ratio DE cord blood vs DE blastocyst cfr-2X-p05 DE cord blood vs DE blastocyst-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 3.994E-7 2.684E-5 2.125E-4 6.155E-4 5 257
23 PCBC EB blastocyst 100 Progenitor-Cell-Biology-Consortium EmbryoidBody fromBlastocyst-derived-humanEmbryonicStemCells top-relative-expression-ranked 100 PCBC 4.006E-7 2.684E-5 2.125E-4 6.174E-4 4 100
24 ratio EB-fibro vs EB-cbCD34 1000 K5 ratio EmbryoidBody-fibro vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 1000 k-means-cluster#5 PCBC 5.995E-7 3.849E-5 3.048E-4 9.238E-4 5 279
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour PapRCC PT-U/Kidney Tumour PapRCC PT4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Tumour PapRCC PT-U/Kidney Tumour PapRCC PT4 Adult, Development, and Cancer types 7.598E-7 4.684E-5 3.708E-4 1.171E-3 3 29
26 PCBC ratio EB blastocyst vs EB amniotic fluid MSC cfr-2X-p05 EB blastocyst vs EB amniotic fluid MSC-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 9.008E-7 5.339E-5 4.227E-4 1.388E-3 5 303
27 Glioblastoma Single Cell Merged Immune cell Subtype Immune cell-Immune cell.7 Top 200 Genes Glioblastoma Single Cell Merged Immune cell Subtype Immune cell-Immune cell.7 Top 200 Genes 1.831E-6 1.045E-4 8.273E-4 2.821E-3 5 350
28 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 1000 k4 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.704E-6 1.488E-4 1.178E-3 4.167E-3 5 379
29 ratio EB-blastocyst vs EB-cbCD34 2500 K3 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 2500 k-means-cluster#3 PCBC 3.189E-6 1.695E-4 1.342E-3 4.915E-3 5 392
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour VHL RCC Nephron epithelium/Kidney Tumour VHL RCC N5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour VHL RCC Nephron epithelium/Kidney Tumour VHL RCC N5 Adult, Development, and Cancer types 3.815E-6 1.960E-4 1.552E-3 5.880E-3 2 5
31 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour PapRCC NK cell/Kidney Tumour PapRCC NK4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Tumour PapRCC NK cell/Kidney Tumour PapRCC NK4 Adult, Development, and Cancer types 4.294E-6 2.135E-4 1.690E-3 6.618E-3 3 51
32 Facebase ST1 Univ 500 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 FaceBase_ST1 4.842E-6 2.332E-4 1.846E-3 7.462E-3 5 427
33 Arv EB-LF 1000 K4 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 1000 k-means-cluster#4 PCBC 5.360E-6 2.436E-4 1.929E-3 8.260E-3 5 436
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Tumour PapRCC R U/Kidney Tumour PapRCC R4 Adult, Development, and Cancer types 5.402E-6 2.436E-4 1.929E-3 8.324E-3 3 55
35 Glioblastoma Single Cell Merged Immune cell Overall Top 200 Genes Glioblastoma Single Cell Merged Immune cell Overall Top 200 Genes 5.532E-6 2.436E-4 1.929E-3 8.525E-3 4 193
36 Lungmap Mouse Lung PND1 Immune Subtype Macrophages-B Lungmap Mouse Lung PND1 Immune Subtype Macrophages-B Lungmap CCHMC 8.171E-6 3.498E-4 2.769E-3 1.259E-2 4 213
37 PCBC EB fibroblast 500 Progenitor-Cell-Biology-Consortium EmbryoidBody from inducedPluripotentialStemCells derived from from fibroblast top-relative-expression-ranked 500 PCBC 1.033E-5 3.854E-4 3.052E-3 1.591E-2 5 499
38 Arv EB-LF 500 AravindRamakr EmbryoidBody-LF top-relative-expression-ranked 500 PCBC 1.033E-5 3.854E-4 3.052E-3 1.591E-2 5 499
39 PCBC ratio EB vs SC 500 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 500 PCBC 1.033E-5 3.854E-4 3.052E-3 1.591E-2 5 499
40 PCBC EB 500 Progenitor-Cell-Biology-Consortium EmbryoidBody top-relative-expression-ranked 500 PCBC 1.033E-5 3.854E-4 3.052E-3 1.591E-2 5 499
41 PCBC ratio DE from-OSKM-L vs DE from-ESC cfr-2X-p05 Endoderm Differentiated Cells-reprogram OSKM-L vs Endoderm Differentiated Cells-reprogram NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.050E-5 3.854E-4 3.052E-3 1.619E-2 4 227
42 PCBC ratio DE from-mRNA vs DE from-ESC cfr-2X-p05 Endoderm Differentiated Cells-method mRNA vs Endoderm Differentiated Cells-method NA-Confounder removed-fold2.0 adjp0.05 PCBC_AltAnalyze 1.050E-5 3.854E-4 3.052E-3 1.619E-2 4 227
43 gudmap developingLowerUrinaryTract e15.5 ureteral tissue 500 k2 DevelopingLowerUrinaryTract e15.5 ureteral tissue emap-8234 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.442E-5 5.167E-4 4.091E-3 2.222E-2 4 246
44 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Rectal Adenocarcinoma/5/0 Sample Type by Project: Shred 1/TCGA-Colorectal/Colorectal Adenocarcinoma/Rectal Adenocarcinoma/5/0 TCGA-Colorectal 1.872E-5 6.556E-4 5.191E-3 2.885E-2 3 83
45 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Tumour PapRCC Junk/Kidney Tumour PapRCC IF4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Junk/Kidney Tumour PapRCC Junk/Kidney Tumour PapRCC IF4 Adult, Development, and Cancer types 1.941E-5 6.645E-4 5.262E-3 2.990E-2 3 84
46 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour PapRCC Th cell/Kidney Tumour PapRCC IN4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Th cell/Kidney Tumour PapRCC Th cell/Kidney Tumour PapRCC IN4 Adult, Development, and Cancer types 2.387E-5 7.997E-4 6.332E-3 3.679E-2 3 90
47 Facebase ST1 Univ 500 1 UniversalReference WholeMouseP1 top-relative-expression-ranked 500 1 FaceBase_ST1 2.512E-5 8.235E-4 6.520E-3 3.871E-2 2 12
48 PCBC ratio EB-blastocyst vs EB-cbCD34 100 ratio EmbryoidBody-blastocyst vs EmbryoidBody-derived-from CD34-iPSC top-relative-expression-ranked 100 PCBC 2.988E-5 9.593E-4 7.595E-3 4.605E-2 3 97
49 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour PapRCC Endothelium Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Tumour PapRCC Endothelium Adult, Development, and Cancer types 3.176E-5 9.989E-4 7.909E-3 4.895E-2 3 99
50 PCBC EB fibroblast 100 Progenitor-Cell-Biology-Consortium EmbryoidBody from inducedPluripotentialStemCells derived from from fibroblast top-relative-expression-ranked 100 PCBC 3.273E-5 1.009E-3 7.988E-3
5.044E-2
 3 100
Show 45 more annotations

15: Computational [Display Chart] 14 input genes in category / 102 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M14916 MODULE 236 Genes in the cancer module 236. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.003E-11 2.043E-9 1.064E-8 2.043E-9 5 18
2 M19777 MODULE 385 Heparin binding. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.758E-8 2.426E-6 1.263E-5 4.853E-6 4 28
3 M15716 MODULE 209 Catabolic peptidases. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.201E-8 3.128E-6 1.629E-5 9.385E-6 5 89
4 M10041 MODULE 172 Genes in the cancer module 172. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.348E-7 3.437E-6 1.790E-5 1.375E-5 5 96
5 M132 GNF2 LCAT Neighborhood of LCAT MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.861E-7 9.917E-6 5.164E-5 4.958E-5 5 124
6 M10917 GNF2 HPN Neighborhood of HPN MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.892E-7 1.082E-5 5.633E-5 7.030E-5 5 133
7 M14108 GNF2 HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.424E-7 1.082E-5 5.633E-5 7.572E-5 5 135
8 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.490E-7 1.210E-5 6.300E-5 9.679E-5 7 453
9 M4487 MODULE 417 Genes in the cancer module 417. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.276E-6 3.712E-5 1.933E-4 3.341E-4 3 22
10 M17919 GNF2 TST Neighborhood of TST MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.005E-5 1.026E-4 5.340E-4 1.026E-3 4 104
11 M10693 GNF2 GSTM1 Neighborhood of GSTM1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.212E-5 1.123E-4 5.850E-4 1.236E-3 4 109
12 M3221 GNF2 CEBPA Neighborhood of CEBPA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.561E-5 7.277E-4 3.789E-3 8.732E-3 3 64
13 M6913 CAR HPX Neighborhood of HPX MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.269E-4 9.953E-4 5.183E-3 1.294E-2 3 73
14 M3789 MODULE 235 AA and sulfur metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.729E-4 1.219E-3 6.348E-3 1.763E-2 3 81
15 M9683 MODULE 40 Organic acid metabolism. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.793E-4 1.219E-3 6.348E-3 1.829E-2 3 82
16 M17170 MODULE 401 Genes in the cancer module 401. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.144E-4 1.367E-3 7.117E-3 2.187E-2 2 16
17 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.184E-3 1.281E-2
6.672E-2
2.228E-1
 4 421
18 M15763 MODULE 60 Heart genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.261E-3 1.281E-2
6.672E-2
2.306E-1
 4 425
19 M10190 MODULE 52 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.421E-3 1.300E-2
6.768E-2
2.470E-1
 4 433
20 M18034 CAR IGFBP1 Neighborhood of IGFBP1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.760E-3 1.408E-2
7.329E-2
2.815E-1
 2 57
21 M17376 MODULE 107 Genes in the cancer module 107. MSigDb: C4 - CM: Cancer Modules (v6.0) 5.235E-3 2.543E-2
1.324E-1
5.340E-1
 2 79
22 M2667 MODULE 19 Adrenal gland - metabolic genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.542E-3 3.960E-2
2.062E-1
8.713E-1
 3 314
Show 17 more annotations

16: MicroRNA [Display Chart] 14 input genes in category / 459 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-148b-3p:Functional MTI Functional MTI miRTarbase 5.992E-5 2.087E-2
1.400E-1
 2.750E-2 3 403
2 hsa-miR-615-3p:mirSVR highEffct hsa-miR-615-3p:mirSVR conserved highEffect-0.5 MicroRNA.org 9.093E-5 2.087E-2
1.400E-1
 4.174E-2 2 73
3 hsa-miR-6869-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.582E-4 3.950E-2
2.650E-1
1.185E-1
 2 123

17: Drug [Display Chart] 14 input genes in category / 5205 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000004912 probucol Stitch 9.787E-28 5.094E-24 4.654E-23 5.094E-24 13 162
2 CID000003339 fenofibrate Stitch 1.221E-24 3.178E-21 2.903E-20 6.357E-21 13 276
3 ctd:D008076 Cholesterol, HDL CTD 4.290E-24 7.442E-21 6.798E-20 2.233E-20 9 29
4 CID000002250 AC1L1D9C Stitch 2.840E-23 3.302E-20 3.016E-19 1.478E-19 13 350
5 CID005310993 acipimox Stitch 3.172E-23 3.302E-20 3.016E-19 1.651E-19 10 69
6 CID000000303 sodium cholate Stitch 2.148E-22 1.863E-19 1.702E-18 1.118E-18 13 408
7 CID000561567 n-heptyl-beta-D-thioglucoside Stitch 1.889E-21 1.405E-18 1.283E-17 9.833E-18 9 53
8 CID000065167 POPC Stitch 2.394E-21 1.558E-18 1.423E-17 1.246E-17 12 306
9 CID000166558 avasimibe Stitch 3.228E-21 1.867E-18 1.705E-17 1.680E-17 9 56
10 CID000031207 1,2,3-trioleoylglycerol Stitch 4.776E-21 2.486E-18 2.271E-17 2.486E-17 10 111
11 CID004475485 AC1NAE4O Stitch 6.903E-21 3.266E-18 2.984E-17 3.593E-17 10 115
12 CID000003962 Epi Lovastatin Stitch 8.956E-21 3.885E-18 3.549E-17 4.662E-17 12 341
13 CID000071388 Exosurf Stitch 1.818E-20 7.278E-18 6.648E-17 9.461E-17 9 67
14 CID000004677 NSC759269 Stitch 2.953E-20 1.098E-17 1.003E-16 1.537E-16 8 34
15 ctd:D001629 Bezafibrate CTD 3.315E-20 1.150E-17 1.051E-16 1.725E-16 11 232
16 CID000004889 AC1L1J6H Stitch 4.016E-20 1.306E-17 1.193E-16 2.090E-16 11 236
17 CID000039042 bezafibrate Stitch 5.320E-20 1.629E-17 1.488E-16 2.769E-16 11 242
18 CID000003157 doxazosin Stitch 1.393E-19 4.028E-17 3.679E-16 7.250E-16 9 83
19 CID000002116 vitamin E Stitch 2.033E-19 5.570E-17 5.088E-16 1.058E-15 12 441
20 CID000011146 tristearin Stitch 2.411E-19 6.275E-17 5.732E-16 1.255E-15 11 277
21 CID000078971 AC1L2WD4 Stitch 2.876E-19 7.128E-17 6.511E-16 1.497E-15 8 44
22 CID000000965 mangrove Stitch 4.176E-19 9.880E-17 9.025E-16 2.174E-15 12 468
23 ctd:D004809 Ephedrine CTD 1.279E-18 2.894E-16 2.643E-15 6.656E-15 6 9
24 CID000004829 pioglitazone Stitch 1.483E-18 3.215E-16 2.937E-15 7.717E-15 11 326
25 CID000035455 feprazone Stitch 1.839E-18 3.682E-16 3.363E-15 9.572E-15 7 24
26 CID000012437 T mu Stitch 1.839E-18 3.682E-16 3.363E-15 9.572E-15 7 24
27 CID000003931 sodium linoleate Stitch 2.527E-18 4.871E-16 4.450E-15 1.315E-14 11 342
28 CID000075420 4-APP Stitch 4.760E-18 8.848E-16 8.082E-15 2.477E-14 8 61
29 CID000003463 gemfibrozil Stitch 5.938E-18 1.066E-15 9.735E-15 3.091E-14 10 222
30 CID000026197 dimyristoylphosphatidylcholine Stitch 7.149E-18 1.240E-15 1.133E-14 3.721E-14 8 64
31 CID000004242 NSC-343257 Stitch 8.142E-18 1.367E-15 1.249E-14 4.238E-14 10 229
32 ctd:D014280 Triglycerides CTD 9.272E-18 1.508E-15 1.378E-14 4.826E-14 8 66
33 CID000054454 simvastatin Stitch 1.087E-17 1.714E-15 1.566E-14 5.658E-14 11 390
34 CID000000084 3-hydroxy-3-methylglutaryl-CoA Stitch 1.154E-17 1.767E-15 1.614E-14 6.007E-14 10 237
35 CID000004542 H088 Stitch 2.718E-17 4.042E-15 3.692E-14 1.415E-13 8 75
36 CID000005857 lynestrenol Stitch 6.681E-17 9.398E-15 8.585E-14 3.477E-13 7 38
37 CID000007510 beta-pyridylcarbinol Stitch 6.681E-17 9.398E-15 8.585E-14 3.477E-13 7 38
38 CID000082755 hydroxytyrosol Stitch 8.140E-17 1.115E-14 1.018E-13 4.237E-13 7 39
39 CID000024341 HOCl Stitch 1.040E-16 1.387E-14 1.267E-13 5.411E-13 9 169
40 CID000039941 benoxaprofen Stitch 1.189E-16 1.547E-14 1.414E-13 6.190E-13 7 41
41 CID000041774 acarbose Stitch 1.785E-16 2.266E-14 2.070E-13 9.292E-13 8 94
42 CID000006776 anthraflavic acid Stitch 2.025E-16 2.510E-14 2.293E-13 1.054E-12 7 44
43 CID000003403 CAS 93957-55-2 Stitch 2.631E-16 3.185E-14 2.909E-13 1.369E-12 9 187
44 CID000000937 niacin Stitch 4.440E-16 5.252E-14 4.797E-13 2.311E-12 9 198
45 CID000040973 desogestrel Stitch 4.823E-16 5.579E-14 5.096E-13 2.510E-12 8 106
46 CID000157691 gemcabene Stitch 5.881E-16 6.654E-14 6.078E-13 3.061E-12 6 20
47 CID000067874 p-trifluoromethylphenol Stitch 1.167E-15 1.292E-13 1.180E-12 6.072E-12 8 118
48 CID000003488 glibenclamide Stitch 1.436E-15 1.558E-13 1.423E-12 7.476E-12 10 382
49 CID006918540 dalcetrapib Stitch 1.530E-15 1.625E-13 1.485E-12 7.965E-12 6 23
50 CID000009904 nandrolone Stitch 1.583E-15 1.648E-13 1.505E-12 8.240E-12 7 58
Show 45 more annotations

18: Disease [Display Chart] 14 input genes in category / 1025 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 20081125:Kathiresan LDL cholesterol GWAS 3.804E-25 3.899E-22 2.928E-21 3.899E-22 10 34
2 C0342883 Cholesteryl Ester Transfer Protein Deficiency DisGeNET Curated 8.704E-25 4.461E-22 3.350E-21 8.921E-22 9 19
3 20090112:Kathiresan HDL cholesterol GWAS 9.232E-24 3.154E-21 2.369E-20 9.463E-21 10 45
4 20081125:Willer HDL cholesterol GWAS 9.410E-23 2.411E-20 1.811E-19 9.645E-20 9 29
5 C0020473 Hyperlipidemia DisGeNET Curated 1.148E-21 2.354E-19 1.768E-18 1.177E-18 12 206
6 C1867743 Coronary artery disease, premature DisGeNET Curated 6.633E-21 1.133E-18 8.510E-18 6.799E-18 9 44
7 C0020557 Hypertriglyceridemia DisGeNET Curated 1.047E-20 1.533E-18 1.152E-17 1.073E-17 11 150
8 20090112:Aulchenko HDL cholesterol GWAS 1.087E-19 1.393E-17 1.046E-16 1.114E-16 8 29
9 C0020445 Hypercholesterolemia, Familial DisGeNET Curated 1.205E-18 1.373E-16 1.031E-15 1.235E-15 10 136
10 C0020443 Hypercholesterolemia DisGeNET Curated 1.364E-18 1.398E-16 1.050E-15 1.398E-15 11 231
11 C0020479 Hyperlipoproteinemia Type III DisGeNET Curated 1.870E-18 1.743E-16 1.309E-15 1.917E-15 7 18
12 C0020476 Hyperlipoproteinemias DisGeNET Curated 6.827E-18 5.831E-16 4.379E-15 6.997E-15 7 21
13 C0154251 Lipid Metabolism Disorders DisGeNET Curated 6.933E-17 5.466E-15 4.105E-14 7.106E-14 7 28
14 C0242339 Dyslipidemias DisGeNET Curated 9.353E-17 6.848E-15 5.143E-14 9.587E-14 10 208
15 C2712907 combined hyperlipidemia DisGeNET Curated 3.577E-16 2.355E-14 1.768E-13 3.666E-13 6 14
16 C0497406 Overweight DisGeNET Curated 3.675E-16 2.355E-14 1.768E-13 3.767E-13 10 238
17 C0745103 Hyperlipoproteinemia Type IIa DisGeNET Curated 8.512E-16 5.132E-14 3.854E-13 8.725E-13 9 152
18 C0023817 Hyperlipoproteinemia Type I DisGeNET Curated 1.472E-15 8.383E-14 6.296E-13 1.509E-12 6 17
19 C2936179 Obesity, Visceral DisGeNET BeFree 2.230E-15 1.203E-13 9.036E-13 2.286E-12 7 44
20 C3149462 HYPERALPHALIPOPROTEINEMIA 1 DisGeNET Curated 1.203E-14 6.165E-13 4.630E-12 1.233E-11 5 8
21 C0020474 Hyperlipidemia, Familial Combined DisGeNET Curated 1.665E-13 7.912E-12 5.942E-11 1.706E-10 7 79
22 C0023195 Lecithin Acyltransferase Deficiency DisGeNET Curated 1.698E-13 7.912E-12 5.942E-11 1.741E-10 5 12
23 C0271650 Impaired glucose tolerance DisGeNET Curated 4.578E-13 2.040E-11 1.532E-10 4.693E-10 9 303
24 C0007820 Cerebrovascular Disorders DisGeNET Curated 8.485E-13 3.549E-11 2.665E-10 8.697E-10 7 99
25 C0302314 Xanthoma DisGeNET Curated 9.348E-13 3.549E-11 2.665E-10 9.582E-10 5 16
26 C0948242 Nuchal bleb, familial DisGeNET Curated 9.348E-13 3.549E-11 2.665E-10 9.582E-10 5 16
27 C0263420 Hyperkeratosis lenticularis perstans DisGeNET Curated 9.348E-13 3.549E-11 2.665E-10 9.582E-10 5 16
28 C0020597 Hypobetalipoproteinemias DisGeNET Curated 2.485E-12 9.098E-11 6.832E-10 2.547E-9 5 19
29 C0039292 Tangier Disease DisGeNET Curated 5.620E-12 1.920E-10 1.442E-9 5.761E-9 5 22
30 C0595929 Serum cholesterol raised DisGeNET Curated 5.620E-12 1.920E-10 1.442E-9 5.761E-9 5 22
31 C0151744 Myocardial Ischemia DisGeNET Curated 8.840E-12 2.923E-10 2.195E-9 9.061E-9 9 421
32 C0155733 Atherosclerosis of aorta DisGeNET Curated 2.526E-11 8.092E-10 6.077E-9 2.589E-8 5 29
33 C0020480 Hyperlipoproteinemia Type IV DisGeNET Curated 1.146E-10 3.560E-9 2.674E-8 1.175E-7 4 11
34 C1704429 Hypoalphalipoproteinemia, Familial DisGeNET Curated 1.718E-10 4.978E-9 3.739E-8 1.761E-7 4 12
35 C1704436 Peripheral Arterial Diseases DisGeNET Curated 1.740E-10 4.978E-9 3.739E-8 1.783E-7 6 104
36 C0042373 Vascular Diseases DisGeNET Curated 1.748E-10 4.978E-9 3.739E-8 1.792E-7 8 368
37 C0015695 Fatty Liver DisGeNET Curated 2.257E-10 6.251E-9 4.695E-8 2.313E-7 8 380
38 20090213:Saxena Triglycerides GWAS 5.133E-10 1.315E-8 9.879E-8 5.262E-7 3 3
39 C0221252 Eruptive xanthoma DisGeNET Curated 5.133E-10 1.315E-8 9.879E-8 5.262E-7 3 3
40 C1291447 Deficiency of triacylglycerol lipase DisGeNET BeFree 5.133E-10 1.315E-8 9.879E-8 5.262E-7 3 3
41 C1096293 Macroangiopathy DisGeNET BeFree 6.305E-10 1.576E-8 1.184E-7 6.463E-7 4 16
42 C0043325 Xanthomatosis DisGeNET Curated 8.241E-10 2.011E-8 1.511E-7 8.447E-7 4 17
43 C0473527 Hypoalphalipoproteinemias DisGeNET Curated 1.341E-9 3.196E-8 2.400E-7 1.374E-6 4 19
44 C2711227 Steatohepatitis DisGeNET Curated 1.610E-9 3.751E-8 2.817E-7 1.650E-6 8 487
45 20090112:Sabatti HDL cholesterol GWAS 2.527E-9 5.755E-8 4.322E-7 2.590E-6 4 22
46 C0333463 Senile Plaques DisGeNET BeFree 2.742E-9 6.110E-8 4.588E-7 2.810E-6 7 311
47 C0400966 Non-alcoholic Fatty Liver Disease DisGeNET Curated 3.131E-9 6.829E-8 5.128E-7 3.209E-6 7 317
48 C0020459 Hyperinsulinism DisGeNET Curated 3.885E-9 8.295E-8 6.230E-7 3.982E-6 7 327
49 C0242383 Age related macular degeneration DisGeNET Curated 4.690E-9 9.810E-8 7.368E-7 4.807E-6 7 336
50 C3272363 Ischemic Cerebrovascular Accident DisGeNET BeFree 5.091E-9 1.011E-7 7.591E-7 5.218E-6 7 340
Show 45 more annotations