Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc170_18, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 55 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0008536 Ran GTPase binding 1.453E-23 7.994E-22 3.672E-21 7.994E-22 10 38
2 GO:0008565 protein transporter activity 5.763E-19 1.585E-17 7.280E-17 3.170E-17 10 101
3 GO:0008139 nuclear localization sequence binding 4.954E-17 9.083E-16 4.172E-15 2.725E-15 7 23
4 GO:0005048 signal sequence binding 5.399E-15 7.423E-14 3.410E-13 2.969E-13 7 42
5 GO:0017016 Ras GTPase binding 2.010E-14 2.211E-13 1.016E-12 1.106E-12 10 281
6 GO:0031267 small GTPase binding 4.010E-14 3.676E-13 1.689E-12 2.206E-12 10 301
7 GO:0051020 GTPase binding 9.200E-14 7.229E-13 3.321E-12 5.060E-12 10 327
8 GO:0042277 peptide binding 4.177E-9 2.872E-8 1.319E-7 2.297E-7 7 278
9 GO:0033218 amide binding 8.681E-9 5.305E-8 2.437E-7 4.775E-7 7 309
10 GO:0019789 SUMO transferase activity 2.602E-4 1.431E-3 6.574E-3 1.431E-2 2 25
11 GO:0003755 peptidyl-prolyl cis-trans isomerase activity 1.089E-3 5.391E-3 2.476E-2
5.992E-2
 2 51
12 GO:0016859 cis-trans isomerase activity 1.176E-3 5.391E-3 2.476E-2
6.469E-2
 2 53
13 GO:0070883 pre-miRNA binding 3.853E-3 1.630E-2
7.488E-2
2.119E-1
 1 4
14 GO:0005087 Ran guanyl-nucleotide exchange factor activity 6.734E-3 2.645E-2
1.215E-1
3.703E-1
 1 7
15 GO:0019787 ubiquitin-like protein transferase activity 8.214E-3 3.012E-2
1.383E-1
4.518E-1
 3 441
16 GO:0016853 isomerase activity 1.147E-2 3.943E-2
1.811E-1
6.309E-1
 2 170
17 GO:0005092 GDP-dissociation inhibitor activity 1.247E-2 4.035E-2
1.853E-1
6.859E-1
 1 13
Show 12 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 344 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006607 NLS-bearing protein import into nucleus 9.301E-22 3.200E-19 2.054E-18 3.200E-19 9 30
2 GO:0006913 nucleocytoplasmic transport 1.978E-19 3.402E-17 2.184E-16 6.805E-17 14 494
3 GO:0034504 protein localization to nucleus 1.029E-16 1.179E-14 7.572E-14 3.538E-14 12 391
4 GO:0006606 protein import into nucleus 4.894E-16 4.209E-14 2.702E-13 1.684E-13 11 302
5 GO:0051170 import into nucleus 9.617E-16 6.617E-14 4.247E-13 3.308E-13 11 321
6 GO:0017038 protein import 2.581E-15 1.480E-13 9.499E-13 8.879E-13 11 351
7 GO:1902583 multi-organism intracellular transport 1.743E-13 7.493E-12 4.810E-11 5.994E-11 7 67
8 GO:0075733 intracellular transport of virus 1.743E-13 7.493E-12 4.810E-11 5.994E-11 7 67
9 GO:0046794 transport of virus 2.398E-13 8.316E-12 5.338E-11 8.250E-11 7 70
10 GO:0044766 multi-organism transport 2.659E-13 8.316E-12 5.338E-11 9.148E-11 7 71
11 GO:1902579 multi-organism localization 2.659E-13 8.316E-12 5.338E-11 9.148E-11 7 71
12 GO:0019054 modulation by virus of host process 3.660E-11 1.049E-9 6.736E-9 1.259E-8 5 27
13 GO:0044068 modulation by symbiont of host cellular process 6.450E-11 1.707E-9 1.096E-8 2.219E-8 5 30
14 GO:0019048 modulation by virus of host morphology or physiology 3.823E-10 9.395E-9 6.031E-8 1.315E-7 5 42
15 GO:0044003 modification by symbiont of host morphology or physiology 1.050E-9 2.409E-8 1.546E-7 3.613E-7 5 51
16 GO:0007059 chromosome segregation 1.475E-8 3.171E-7 2.036E-6 5.073E-6 7 333
17 GO:0051168 nuclear export 1.640E-8 3.319E-7 2.130E-6 5.642E-6 6 188
18 GO:0051817 modification of morphology or physiology of other organism involved in symbiotic interaction 2.662E-8 5.088E-7 3.266E-6 9.158E-6 5 96
19 GO:0006610 ribosomal protein import into nucleus 6.346E-8 1.137E-6 7.299E-6 2.183E-5 3 9
20 GO:0035821 modification of morphology or physiology of other organism 6.611E-8 1.137E-6 7.299E-6 2.274E-5 5 115
21 GO:0019058 viral life cycle 1.109E-7 1.816E-6 1.166E-5 3.814E-5 7 447
22 GO:0000060 protein import into nucleus, translocation 1.736E-7 2.715E-6 1.743E-5 5.974E-5 4 53
23 GO:0006611 protein export from nucleus 3.743E-7 5.598E-6 3.594E-5 1.288E-4 4 64
24 GO:0051701 interaction with host 4.929E-7 7.064E-6 4.535E-5 1.695E-4 5 172
25 GO:0050657 nucleic acid transport 6.006E-7 7.946E-6 5.101E-5 2.066E-4 5 179
26 GO:0050658 RNA transport 6.006E-7 7.946E-6 5.101E-5 2.066E-4 5 179
27 GO:0051236 establishment of RNA localization 6.521E-7 8.308E-6 5.333E-5 2.243E-4 5 182
28 GO:0006403 RNA localization 1.450E-6 1.760E-5 1.130E-4 4.990E-4 5 214
29 GO:0015931 nucleobase-containing compound transport 1.484E-6 1.760E-5 1.130E-4 5.105E-4 5 215
30 GO:0000819 sister chromatid segregation 1.856E-6 2.128E-5 1.366E-4 6.384E-4 5 225
31 GO:0007079 mitotic chromosome movement towards spindle pole 5.288E-6 5.868E-5 3.767E-4 1.819E-3 2 4
32 GO:0098813 nuclear chromosome segregation 5.699E-6 6.127E-5 3.933E-4 1.961E-3 5 283
33 GO:0051305 chromosome movement towards spindle pole 1.848E-5 1.926E-4 1.236E-3 6.356E-3 2 7
34 GO:0046822 regulation of nucleocytoplasmic transport 6.690E-5 6.535E-4 4.195E-3 2.301E-2 4 236
35 GO:1903300 negative regulation of hexokinase activity 6.839E-5 6.535E-4 4.195E-3 2.353E-2 2 13
36 GO:0033132 negative regulation of glucokinase activity 6.839E-5 6.535E-4 4.195E-3 2.353E-2 2 13
37 GO:0033131 regulation of glucokinase activity 1.190E-4 1.106E-3 7.101E-3 4.093E-2 2 17
38 GO:1903299 regulation of hexokinase activity 1.338E-4 1.211E-3 7.774E-3 4.602E-2 2 18
39 GO:0006405 RNA export from nucleus 1.984E-4 1.733E-3 1.112E-2
6.824E-2
 3 120
40 GO:0006309 apoptotic DNA fragmentation 2.015E-4 1.733E-3 1.112E-2
6.932E-2
 2 22
41 GO:0007062 sister chromatid cohesion 2.345E-4 1.968E-3 1.263E-2
8.067E-2
 3 127
42 GO:0000737 DNA catabolic process, endonucleolytic 2.829E-4 2.317E-3 1.487E-2
9.730E-2
 2 26
43 GO:0016925 protein sumoylation 3.124E-4 2.499E-3 1.604E-2
1.075E-1
 3 140
44 GO:0007051 spindle organization 3.677E-4 2.867E-3 1.840E-2
1.265E-1
 3 148
45 GO:0007088 regulation of mitotic nuclear division 3.750E-4 2.867E-3 1.840E-2
1.290E-1
 3 149
46 GO:0051028 mRNA transport 3.900E-4 2.916E-3 1.872E-2
1.341E-1
 3 151
47 GO:0030262 apoptotic nuclear changes 4.302E-4 3.149E-3 2.021E-2
1.480E-1
 2 32
48 GO:0006308 DNA catabolic process 4.860E-4 3.483E-3 2.236E-2
1.672E-1
 2 34
49 GO:0033157 regulation of intracellular protein transport 5.197E-4 3.648E-3 2.342E-2
1.788E-1
 4 403
50 GO:0046825 regulation of protein export from nucleus 5.760E-4 3.963E-3 2.544E-2
1.981E-1
 2 37
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 39 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005635 nuclear envelope 4.353E-20 1.698E-18 7.220E-18 1.698E-18 14 454
2 GO:0005643 nuclear pore 1.898E-17 3.700E-16 1.574E-15 7.401E-16 9 84
3 GO:0031965 nuclear membrane 9.998E-11 1.300E-9 5.529E-9 3.899E-9 8 290
4 GO:0044614 nuclear pore cytoplasmic filaments 5.048E-6 4.922E-5 2.094E-4 1.969E-4 2 4
5 GO:0034399 nuclear periphery 2.623E-4 2.046E-3 8.702E-3 1.023E-2 3 135
6 GO:1904115 axon cytoplasm 5.206E-4 3.384E-3 1.439E-2 2.030E-2 2 36
7 GO:1990723 cytoplasmic periphery of the nuclear pore complex 9.443E-4 5.261E-3 2.238E-2 3.683E-2 1 1
8 GO:0032838 plasma membrane bounded cell projection cytoplasm 1.590E-3 7.750E-3 3.297E-2
6.200E-2
 2 63
9 GO:0042565 RNA nuclear export complex 1.888E-3 8.181E-3 3.480E-2
7.363E-2
 1 2
10 GO:0031074 nucleocytoplasmic transport complex 3.772E-3 1.337E-2
5.689E-2
1.471E-1
 1 4
11 GO:0005642 annulate lamellae 3.772E-3 1.337E-2
5.689E-2
1.471E-1
 1 4
12 GO:0044615 nuclear pore nuclear basket 4.713E-3 1.414E-2
6.014E-2
1.838E-1
 1 5
13 GO:0044613 nuclear pore central transport channel 4.713E-3 1.414E-2
6.014E-2
1.838E-1
 1 5
14 GO:0000776 kinetochore 6.000E-3 1.671E-2
7.109E-2
2.340E-1
 2 124
15 GO:0000922 spindle pole 6.872E-3 1.787E-2
7.600E-2
2.680E-1
 2 133
16 GO:0005875 microtubule associated complex 9.344E-3 2.278E-2
9.688E-2
3.644E-1
 2 156
17 GO:0071782 endoplasmic reticulum tubular network 1.128E-2 2.443E-2
1.039E-1
4.398E-1
 1 12
18 GO:0042405 nuclear inclusion body 1.128E-2 2.443E-2
1.039E-1
4.398E-1
 1 12
19 GO:0031616 spindle pole centrosome 1.221E-2 2.506E-2
1.066E-1
4.762E-1
 1 13
20 GO:0000775 chromosome, centromeric region 1.294E-2 2.524E-2
1.074E-1
5.048E-1
 2 185
21 GO:0098827 endoplasmic reticulum subcompartment 1.501E-2 2.787E-2
1.186E-1
5.853E-1
 1 16
22 GO:0000793 condensed chromosome 1.616E-2 2.865E-2
1.219E-1
6.304E-1
 2 208
23 GO:0005640 nuclear outer membrane 2.336E-2 3.961E-2
1.685E-1
9.109E-1
 1 25
Show 18 more annotations

4: Human Phenotype [Display Chart] 3 input genes in category / 225 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 14 input genes in category / 249 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 18 input genes in category / 100 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR011989 ARM-like InterPro 1.343E-14 1.343E-12 6.965E-12 1.343E-12 10 271
2 1.25.10.10 - Gene3D 1.735E-13 7.488E-12 3.884E-11 1.735E-11 9 222
3 PF00514 Arm Pfam 2.246E-13 7.488E-12 3.884E-11 2.246E-11 6 31
4 SM00913 IBN N SMART 1.934E-12 4.836E-11 2.509E-10 1.934E-10 5 16
5 IPR001494 Importin-beta N InterPro 2.739E-12 5.412E-11 2.808E-10 2.739E-10 5 17
6 IPR000225 Armadillo InterPro 3.247E-12 5.412E-11 2.808E-10 3.247E-10 6 47
7 IPR016024 ARM-type fold InterPro 8.092E-12 1.156E-10 5.997E-10 8.092E-10 9 340
8 PF01749 IBB Pfam 2.083E-11 1.894E-10 9.824E-10 2.083E-9 4 7
9 IPR024931 Importing su alpha InterPro 2.083E-11 1.894E-10 9.824E-10 2.083E-9 4 7
10 PF16186 Arm 3 Pfam 2.083E-11 1.894E-10 9.824E-10 2.083E-9 4 7
11 IPR032413 Arm 3 InterPro 2.083E-11 1.894E-10 9.824E-10 2.083E-9 4 7
12 PS51214 IBB PROSITE 4.164E-11 3.470E-10 1.800E-9 4.164E-9 4 8
13 IPR002652 Importin-a IBB InterPro 7.491E-11 5.762E-10 2.989E-9 7.491E-9 4 9
14 SM00185 ARM SMART 2.874E-10 2.053E-9 1.065E-8 2.874E-8 5 40
15 PS50166 IMPORTIN B NT PROSITE 5.933E-10 3.956E-9 2.052E-8 5.933E-8 4 14
16 PF03810 IBN N Pfam 8.086E-10 5.054E-9 2.622E-8 8.086E-8 4 15
17 PS50176 ARM REPEAT PROSITE 5.333E-8 3.137E-7 1.627E-6 5.333E-6 4 40
18 PF00638 Ran BP1 Pfam 1.629E-7 8.576E-7 4.449E-6 1.629E-5 3 12
19 PS50196 RANBD1 PROSITE 1.629E-7 8.576E-7 4.449E-6 1.629E-5 3 12
20 IPR000156 Ran bind dom InterPro 2.117E-7 1.008E-6 5.229E-6 2.117E-5 3 13
21 SM00160 RanBD SMART 2.117E-7 1.008E-6 5.229E-6 2.117E-5 3 13
22 IPR000357 HEAT InterPro 2.449E-7 1.113E-6 5.776E-6 2.449E-5 4 58
23 PS50077 HEAT REPEAT PROSITE 5.256E-7 2.285E-6 1.185E-5 5.256E-5 4 70
24 PF02985 HEAT Pfam 1.254E-5 5.018E-5 2.603E-4 1.254E-3 3 48
25 PF08389 Xpo1 Pfam 1.305E-5 5.018E-5 2.603E-4 1.305E-3 2 6
26 IPR013598 Exportin-1/Importin-b-like InterPro 1.305E-5 5.018E-5 2.603E-4 1.305E-3 2 6
27 PF00415 RCC1 Pfam 1.640E-4 6.034E-4 3.130E-3 1.640E-2 2 20
28 PS00626 RCC1 2 PROSITE 1.811E-4 6.034E-4 3.130E-3 1.811E-2 2 21
29 PS50012 RCC1 3 PROSITE 1.811E-4 6.034E-4 3.130E-3 1.811E-2 2 21
30 PS00625 RCC1 1 PROSITE 1.811E-4 6.034E-4 3.130E-3 1.811E-2 2 21
31 PF00641 zf-RanBP Pfam 1.991E-4 6.034E-4 3.130E-3 1.991E-2 2 22
32 2.130.10.30 - Gene3D 1.991E-4 6.034E-4 3.130E-3 1.991E-2 2 22
33 IPR000408 Reg chr condens InterPro 1.991E-4 6.034E-4 3.130E-3 1.991E-2 2 22
34 PS50199 ZF RANBP2 2 PROSITE 2.180E-4 6.054E-4 3.141E-3 2.180E-2 2 23
35 SM00547 ZnF RBZ SMART 2.180E-4 6.054E-4 3.141E-3 2.180E-2 2 23
36 IPR009091 RCC1/BLIP-II InterPro 2.180E-4 6.054E-4 3.141E-3 2.180E-2 2 23
37 PS01358 ZF RANBP2 1 PROSITE 2.376E-4 6.423E-4 3.332E-3 2.376E-2 2 24
38 IPR001876 Znf RanBP2 InterPro 2.581E-4 6.793E-4 3.524E-3 2.581E-2 2 25
39 IPR022011 IR1-M InterPro 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
40 IPR015458 MDM4 InterPro 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
41 SM01102 CRM1 C SMART 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
42 1.25.40.200 - Gene3D 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
43 PF12185 IR1-M Pfam 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
44 IPR009109 Ran GTPase activating 1 C InterPro 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
45 PF07834 RanGAP1 C Pfam 9.608E-4 2.135E-3 1.108E-2
9.608E-2
 1 1
46 IPR016495 p53 neg-reg MDM 2/4 InterPro 1.921E-3 4.001E-3 2.076E-2
1.921E-1
 1 2
47 PF08767 CRM1 C Pfam 1.921E-3 4.001E-3 2.076E-2
1.921E-1
 1 2
48 IPR014877 CRM1 C dom InterPro 1.921E-3 4.001E-3 2.076E-2
1.921E-1
 1 2
49 PF00515 TPR 1 Pfam 3.321E-3 6.643E-3 3.446E-2
3.321E-1
 2 90
50 IPR001440 TPR 1 InterPro 3.321E-3 6.643E-3 3.446E-2
3.321E-1
 2 90
Show 45 more annotations

7: Pathway [Display Chart] 16 input genes in category / 139 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M17370 Role of Ran in mitotic spindle regulation MSigDB C2 BIOCARTA (v6.0) 4.403E-13 6.120E-11 3.376E-10 6.120E-11 5 10
2 1269095 Interactions of Rev with host cellular proteins BioSystems: REACTOME 2.957E-12 2.055E-10 1.134E-9 4.111E-10 6 36
3 1269131 NS1 Mediated Effects on Host Pathways BioSystems: REACTOME 5.812E-12 2.062E-10 1.137E-9 8.079E-10 6 40
4 1269056 Infectious disease BioSystems: REACTOME 5.933E-12 2.062E-10 1.137E-9 8.246E-10 10 393
5 1269130 Host Interactions with Influenza Factors BioSystems: REACTOME 7.932E-12 2.205E-10 1.216E-9 1.103E-9 6 42
6 1269091 Host Interactions of HIV factors BioSystems: REACTOME 1.675E-10 3.880E-9 2.140E-8 2.328E-8 7 136
7 1269317 ISG15 antiviral mechanism BioSystems: REACTOME 3.499E-10 6.080E-9 3.353E-8 4.864E-8 6 77
8 1269316 Antiviral mechanism by IFN-stimulated genes BioSystems: REACTOME 3.499E-10 6.080E-9 3.353E-8 4.864E-8 6 77
9 1269085 Rev-mediated nuclear export of HIV RNA BioSystems: REACTOME 4.777E-10 6.704E-9 3.698E-8 6.640E-8 5 34
10 1269108 Influenza Infection BioSystems: REACTOME 4.823E-10 6.704E-9 3.698E-8 6.704E-8 7 158
11 1269057 HIV Infection BioSystems: REACTOME 8.945E-9 1.130E-7 6.234E-7 1.243E-6 7 240
12 1269058 HIV Life Cycle BioSystems: REACTOME 2.349E-8 2.721E-7 1.501E-6 3.265E-6 6 154
13 177876 RNA transport BioSystems: KEGG 4.394E-8 4.699E-7 2.591E-6 6.108E-6 6 171
14 1269311 Interferon Signaling BioSystems: REACTOME 1.185E-7 1.176E-6 6.487E-6 1.647E-5 6 202
15 138029 Sumoylation by RanBP2 regulates transcriptional repression BioSystems: Pathway Interaction Database 2.856E-7 2.646E-6 1.459E-5 3.969E-5 3 11
16 1269069 Late Phase of HIV Life Cycle BioSystems: REACTOME 6.856E-7 5.956E-6 3.285E-5 9.530E-5 5 141
17 1269114 Transport of Ribonucleoproteins into the Host Nucleus BioSystems: REACTOME 7.658E-6 6.262E-5 3.454E-4 1.065E-3 3 31
18 1269096 Nuclear import of Rev protein BioSystems: REACTOME 9.281E-6 7.167E-5 3.953E-4 1.290E-3 3 33
19 138062 Signaling events mediated by HDAC Class II BioSystems: Pathway Interaction Database 1.017E-5 7.441E-5 4.104E-4 1.414E-3 3 34
20 1269109 Influenza Life Cycle BioSystems: REACTOME 3.041E-5 2.113E-4 1.166E-3 4.226E-3 4 147
21 137953 Role of Calcineurin-dependent NFAT signaling in lymphocytes BioSystems: Pathway Interaction Database 3.493E-5 2.312E-4 1.275E-3 4.855E-3 3 51
22 137997 Signaling events mediated by HDAC Class I BioSystems: Pathway Interaction Database 7.585E-5 4.793E-4 2.643E-3 1.054E-2 3 66
23 1270293 Activation of DNA fragmentation factor BioSystems: REACTOME 1.198E-4 6.938E-4 3.826E-3 1.665E-2 2 13
24 1270292 Apoptosis induced DNA fragmentation BioSystems: REACTOME 1.198E-4 6.938E-4 3.826E-3 1.665E-2 2 13
25 138015 Regulation of cytoplasmic and nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 2.614E-4 1.454E-3 8.017E-3 3.634E-2 2 19
26 1269821 Resolution of Sister Chromatid Cohesion BioSystems: REACTOME 2.848E-4 1.522E-3 8.397E-3 3.958E-2 3 103
27 1269820 Mitotic Prometaphase BioSystems: REACTOME 3.549E-4 1.827E-3 1.008E-2 4.934E-2 3 111
28 1269519 RHO GTPases Activate Formins BioSystems: REACTOME 4.143E-4 2.057E-3 1.134E-2
5.759E-2
 3 117
29 1269810 M Phase BioSystems: REACTOME 5.480E-4 2.627E-3 1.449E-2
7.618E-2
 4 311
30 1269123 NEP/NS2 Interacts with the Cellular Export Machinery BioSystems: REACTOME 7.046E-4 3.264E-3 1.800E-2
9.793E-2
 2 31
31 1269121 Export of Viral Ribonucleoproteins from Nucleus BioSystems: REACTOME 7.510E-4 3.367E-3 1.857E-2
1.044E-1
 2 32
32 1269094 Vpr-mediated nuclear import of PICs BioSystems: REACTOME 7.988E-4 3.470E-3 1.914E-2
1.110E-1
 2 33
33 1269817 Nuclear Pore Complex (NPC) Disassembly BioSystems: REACTOME 8.988E-4 3.777E-3 2.083E-2
1.249E-1
 2 35
34 1269092 Interactions of Vpr with host cellular proteins BioSystems: REACTOME 9.510E-4 3.777E-3 2.083E-2
1.322E-1
 2 36
35 169350 Signaling events mediated by TCPTP BioSystems: Pathway Interaction Database 9.510E-4 3.777E-3 2.083E-2
1.322E-1
 2 36
36 1269826 Separation of Sister Chromatids BioSystems: REACTOME 1.229E-3 4.745E-3 2.617E-2
1.708E-1
 3 170
37 217173 Influenza A BioSystems: KEGG 1.293E-3 4.856E-3 2.678E-2
1.797E-1
 3 173
38 1269825 Mitotic Anaphase BioSystems: REACTOME 1.472E-3 5.331E-3 2.940E-2
2.046E-1
 3 181
39 1269823 Mitotic Metaphase and Anaphase BioSystems: REACTOME 1.496E-3 5.331E-3 2.940E-2
2.079E-1
 3 182
40 1339113 SUMOylation of DNA replication proteins BioSystems: REACTOME 1.551E-3 5.389E-3 2.972E-2
2.155E-1
 2 46
41 1269815 Nuclear Envelope Breakdown BioSystems: REACTOME 1.978E-3 6.705E-3 3.698E-2
2.749E-1
 2 52
42 1270287 Apoptotic execution phase BioSystems: REACTOME 2.054E-3 6.797E-3 3.749E-2
2.855E-1
 2 53
43 1269509 RHO GTPase Effectors BioSystems: REACTOME 5.865E-3 1.896E-2
1.046E-1
8.153E-1
 3 295
44 1269725 Regulation of mRNA stability by proteins that bind AU-rich elements BioSystems: REACTOME 6.188E-3 1.955E-2
1.078E-1
8.601E-1
 2 93
45 1268743 SUMO E3 ligases SUMOylate target proteins BioSystems: REACTOME 7.684E-3 2.323E-2
1.281E-1
1.000E0
 2 104
46 1309097 Sensing of DNA Double Strand Breaks BioSystems: REACTOME 7.688E-3 2.323E-2
1.281E-1
1.000E0
 1 6
47 1268738 SUMOylation BioSystems: REACTOME 8.562E-3 2.532E-2
1.397E-1
1.000E0
 2 110
48 P04392 P53 pathway feedback loops 1 PantherDB 8.964E-3 2.543E-2
1.402E-1
1.000E0
 1 7
49 1269816 Activation of NIMA Kinases NEK9, NEK6, NEK7 BioSystems: REACTOME 8.964E-3 2.543E-2
1.402E-1
1.000E0
 1 7
50 1269730 HuR (ELAVL1) binds and stabilizes mRNA BioSystems: REACTOME 1.024E-2 2.846E-2
1.570E-1
1.000E0
 1 8
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 1963 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 9562972 HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr. Pubmed 4.463E-22 8.761E-19 7.148E-18 8.761E-19 7 11
2 20015032 Blocking nuclear import of pre-integration complex: an emerging anti-HIV-1 drug discovery paradigm. Pubmed 1.206E-19 3.943E-17 3.218E-16 2.367E-16 6 8
3 9366553 HIV-1 nuclear import: in search of a leader. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
4 10525473 HIV-1 nuclear import: in search of a leader. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
5 10888652 The karyophilic properties of human immunodeficiency virus type 1 integrase are not required for nuclear import of proviral DNA. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
6 10860744 Two nuclear localization signals in the HIV-1 matrix protein regulate nuclear import of the HIV-1 pre-integration complex. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
7 12368302 Nuclear localization of human immunodeficiency virus type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic integrase mutants primarily defective for integration, not PIC nuclear import. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
8 10366569 Nuclear localization of human immunodeficiency virus type 1 integrase expressed as a fusion protein with green fluorescent protein. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
9 11035935 Cellular distribution and karyophilic properties of matrix, integrase, and Vpr proteins from the human and simian immunodeficiency viruses. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
10 9463369 Viral protein R regulates nuclear import of the HIV-1 pre-integration complex. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
11 1631159 Active nuclear import of human immunodeficiency virus type 1 preintegration complexes. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
12 21326825 Transportin 3 and importin α are required for effective nuclear import of HIV-1 integrase in virus-infected cells. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
13 11389849 HIV-1 infection requires a functional integrase NLS. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
14 26399853 Changing expression and subcellular distribution of karyopherins during murine oogenesis. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
15 9275210 HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
16 8105392 A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
17 11278458 Characterization of the nuclear import pathway for HIV-1 integrase. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
18 12414950 Reassessment of the roles of integrase and the central DNA flap in human immunodeficiency virus type 1 nuclear import. Pubmed 3.616E-19 3.943E-17 3.218E-16 7.098E-16 6 9
19 22509482 The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access nucleus and successful integration. Pubmed 1.988E-18 2.054E-16 1.676E-15 3.902E-15 6 11
20 10026238 Three distinct classes of the alpha-subunit of the nuclear pore-targeting complex (importin-alpha) are differentially expressed in adult mouse tissues. Pubmed 7.591E-17 7.450E-15 6.079E-14 1.490E-13 5 6
21 10523667 Evidence for distinct substrate specificities of importin alpha family members in nuclear protein import. Pubmed 2.656E-16 2.370E-14 1.934E-13 5.214E-13 5 7
22 19412186 Active nuclear import and cytoplasmic retention of activation-induced deaminase. Pubmed 2.656E-16 2.370E-14 1.934E-13 5.214E-13 5 7
23 15689618 Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. Pubmed 3.184E-15 2.718E-13 2.218E-12 6.251E-12 5 10
24 10473610 GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358. Pubmed 3.452E-14 2.823E-12 2.304E-11 6.776E-11 4 4
25 10668806 The C-terminal domain of TAP interacts with the nuclear pore complex and promotes export of specific CTE-bearing RNA substrates. Pubmed 7.804E-14 6.128E-12 5.000E-11 1.532E-10 5 17
26 7882974 Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
27 9817747 Characterization of HIV-1 vpr nuclear import: analysis of signals and pathways. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
28 10772949 Intranuclear binding by the HIV-1 regulatory protein VPR is dependent on cytosolic factors. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
29 15342649 AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
30 19961612 Inhibition of HIV-1 integrase nuclear import and replication by a peptide bearing integrase putative nuclear localization signal. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
31 9369227 Identification of novel homologues of mouse importin alpha, the alpha subunit of the nuclear pore-targeting complex, and their tissue-specific expression. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
32 20818336 An actin-regulated importin α/β-dependent extended bipartite NLS directs nuclear import of MRTF-A. Pubmed 1.725E-13 1.058E-11 8.637E-11 3.387E-10 4 5
33 7585960 HIV nuclear import is governed by the phosphotyrosine-mediated binding of matrix to the core domain of integrase. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
34 11904219 Inhibition of nuclear import by backbone cyclic peptidomimetics derived from the HIV-1 MA NLS sequence. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
35 9593140 CNI-H0294, a nuclear importation inhibitor of the human immunodeficiency virus type 1 genome, abrogates virus replication in infected activated peripheral blood mononuclear cells. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
36 8529100 Nuclear localization signal of HIV-1 as a novel target for therapeutic intervention. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
37 9557700 The putative alpha helix 2 of human immunodeficiency virus type 1 Vpr contains a determinant which is responsible for the nuclear translocation of proviral DNA in growth-arrested cells. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
38 8876228 Critical role of reverse transcriptase in the inhibitory mechanism of CNI-H0294 on HIV-1 nuclear translocation. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
39 26491019 Retinoblastoma-binding Protein 4-regulated Classical Nuclear Transport Is Involved in Cellular Senescence. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
40 9918876 Phenotype of HIV-1 lacking a functional nuclear localization signal in matrix protein of gag and Vpr is comparable to wild-type HIV-1 in primary macrophages. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
41 7859280 HIV-1 infection of nondividing cells: C-terminal tyrosine phosphorylation of the viral matrix protein is a key regulator. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
42 9548947 Backbone cyclic peptide, which mimics the nuclear localization signal of human immunodeficiency virus type 1 matrix protein, inhibits nuclear import and virus production in nondividing cells. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
43 8659115 Evidence for direct association of Vpr and matrix protein p17 within the HIV-1 virion. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
44 8041786 The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in nondividing host cells. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
45 19801544 Characterization of nuclear localization signal in the N terminus of CUL4B and its essential role in cyclin E degradation and cell cycle progression. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
46 9303297 HIV-1 infection of non-dividing cells: evidence that the amino-terminal basic region of the viral matrix protein is important for Gag processing but not for post-entry nuclear import. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
47 2064827 p17 and p17-containing gag precursors of input human immunodeficiency virus are transported into the nuclei of infected cells. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
48 15037073 A synthetic peptide bearing the HIV-1 integrase 161-173 amino acid residues mediates active nuclear import and binding to importin alpha: characterization of a functional nuclear localization signal. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
49 7745752 Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage infection. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
50 9603322 A role for human immunodeficiency virus type 1 Vpr during infection of peripheral blood mononuclear cells. Pubmed 5.175E-13 1.881E-11 1.535E-10 1.016E-9 4 6
Show 45 more annotations

9: Interaction [Display Chart] 18 input genes in category / 2075 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:RAN RAN interactions 2.839E-31 5.891E-28 4.839E-27 5.891E-28 16 167
2 int:NUP153 NUP153 interactions 9.601E-23 9.961E-20 8.183E-19 1.992E-19 12 120
3 int:RCC1 RCC1 interactions 1.778E-18 1.230E-15 1.010E-14 3.689E-15 10 107
4 int:KPNB1 KPNB1 interactions 4.473E-16 2.320E-13 1.906E-12 9.281E-13 11 285
5 int:B2M B2M interactions 1.813E-14 7.526E-12 6.183E-11 3.763E-11 7 47
6 int:NUP50 NUP50 interactions 3.255E-14 1.126E-11 9.246E-11 6.753E-11 8 100
7 int:CTDSPL2 CTDSPL2 interactions 1.271E-13 3.767E-11 3.095E-10 2.637E-10 6 27
8 int:RANBP2 RANBP2 interactions 9.462E-13 2.454E-10 2.016E-9 1.963E-9 8 151
9 int:NEMP1 NEMP1 interactions 1.969E-11 4.540E-9 3.729E-8 4.086E-8 5 23
10 int:NUP62 NUP62 interactions 8.288E-10 1.563E-7 1.284E-6 1.720E-6 6 109
11 int:NUP107 NUP107 interactions 8.288E-10 1.563E-7 1.284E-6 1.720E-6 6 109
12 int:RGPD5 RGPD5 interactions 9.868E-10 1.706E-7 1.402E-6 2.048E-6 5 48
13 int:KPNA2 KPNA2 interactions 1.337E-9 2.134E-7 1.753E-6 2.774E-6 7 224
14 int:CSNK1A1 CSNK1A1 interactions 1.657E-9 2.455E-7 2.017E-6 3.437E-6 7 231
15 int:AICDA AICDA interactions 2.190E-9 2.984E-7 2.452E-6 4.545E-6 5 56
16 int:IPO5 IPO5 interactions 2.301E-9 2.984E-7 2.452E-6 4.775E-6 6 129
17 int:RANGAP1 RANGAP1 interactions 3.936E-9 4.805E-7 3.947E-6 8.168E-6 6 141
18 int:NUP214 NUP214 interactions 1.194E-8 1.377E-6 1.131E-5 2.478E-5 5 78
19 int:UBR5 UBR5 interactions 1.542E-8 1.684E-6 1.383E-5 3.200E-5 6 177
20 int:MEPCE MEPCE interactions 2.430E-8 2.521E-6 2.071E-5 5.043E-5 6 191
21 int:NUP98 NUP98 interactions 2.610E-8 2.579E-6 2.119E-5 5.416E-5 5 91
22 int:KPNA4 KPNA4 interactions 2.758E-8 2.602E-6 2.137E-5 5.724E-5 5 92
23 int:KPNA3 KPNA3 interactions 2.913E-8 2.628E-6 2.159E-5 6.045E-5 5 93
24 int:MMS19 MMS19 interactions 3.198E-8 2.765E-6 2.272E-5 6.636E-5 6 200
25 int:CA9 CA9 interactions 3.404E-8 2.825E-6 2.321E-5 7.062E-5 4 34
26 int:IPO9 IPO9 interactions 3.795E-8 3.029E-6 2.488E-5 7.875E-5 5 98
27 int:CDKN1B CDKN1B interactions 4.419E-8 3.396E-6 2.790E-5 9.168E-5 5 101
28 int:MAT2B MAT2B interactions 9.006E-8 6.674E-6 5.483E-5 1.869E-4 4 43
29 int:RANBP1 RANBP1 interactions 1.189E-7 8.504E-6 6.986E-5 2.466E-4 4 46
30 int:G3BP1 G3BP1 interactions 1.447E-7 9.699E-6 7.968E-5 3.002E-4 7 442
31 int:FAM204A FAM204A interactions 1.449E-7 9.699E-6 7.968E-5 3.007E-4 3 11
32 int:NCBP2 NCBP2 interactions 1.814E-7 1.177E-5 9.665E-5 3.765E-4 4 51
33 int:PPM1D PPM1D interactions 1.964E-7 1.235E-5 1.015E-4 4.076E-4 4 52
34 int:GTF2IRD1 GTF2IRD1 interactions 2.292E-7 1.399E-5 1.149E-4 4.755E-4 4 54
35 int:CSE1L CSE1L interactions 2.613E-7 1.549E-5 1.273E-4 5.423E-4 5 144
36 int:CRY2 CRY2 interactions 3.892E-7 2.243E-5 1.843E-4 8.076E-4 5 156
37 int:COMTD1 COMTD1 interactions 4.292E-7 2.407E-5 1.977E-4 8.906E-4 4 63
38 int:IPO8 IPO8 interactions 4.872E-7 2.660E-5 2.186E-4 1.011E-3 4 65
39 int:CHD8 CHD8 interactions 5.849E-7 3.112E-5 2.557E-4 1.214E-3 4 68
40 int:RELA RELA interactions 1.092E-6 5.667E-5 4.655E-4 2.267E-3 6 364
41 int:HNRNPC HNRNPC interactions 1.145E-6 5.797E-5 4.762E-4 2.377E-3 5 194
42 int:PTMA PTMA interactions 1.810E-6 8.942E-5 7.346E-4 3.756E-3 4 90
43 int:DLGAP5 DLGAP5 interactions 2.262E-6 1.091E-4 8.965E-4 4.693E-3 3 26
44 int:TMA16 TMA16 interactions 3.522E-6 1.589E-4 1.305E-3 7.309E-3 3 30
45 int:VSIG2 VSIG2 interactions 3.522E-6 1.589E-4 1.305E-3 7.309E-3 3 30
46 int:IER2 IER2 interactions 3.522E-6 1.589E-4 1.305E-3 7.309E-3 3 30
47 int:VCAM1 VCAM1 interactions 4.033E-6 1.781E-4 1.463E-3 8.368E-3 6 456
48 int:SRP19 SRP19 interactions 5.179E-6 2.239E-4 1.839E-3 1.075E-2 3 34
49 int:NUSAP1 NUSAP1 interactions 5.660E-6 2.397E-4 1.969E-3 1.175E-2 3 35
50 int:EPAS1 EPAS1 interactions 6.096E-6 2.482E-4 2.039E-3 1.265E-2 4 122
Show 45 more annotations

10: Cytoband [Display Chart] 18 input genes in category / 18 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q25.33 3q25.33 7.763E-3 3.826E-2
1.337E-1
1.397E-1
 1 15
2 2q12.3 2q12.3 8.794E-3 3.826E-2
1.337E-1
1.583E-1
 1 17
3 1p36.1 1p36.1 1.137E-2 3.826E-2
1.337E-1
2.046E-1
 1 22
4 3q21 3q21 1.239E-2 3.826E-2
1.337E-1
2.231E-1
 1 24
5 22q13 22q13 1.342E-2 3.826E-2
1.337E-1
2.416E-1
 1 26
6 14q22.3 14q22.3 1.393E-2 3.826E-2
1.337E-1
2.508E-1
 1 27
7 17q24.2 17q24.2 1.598E-2 3.826E-2
1.337E-1
2.877E-1
 1 31
8 2p15 2p15 1.700E-2 3.826E-2
1.337E-1
3.061E-1
 1 33
9 13q14.3 13q14.3 2.108E-2 4.115E-2
1.438E-1
3.795E-1
 1 41
10 17q21.32 17q21.32 2.515E-2 4.115E-2
1.438E-1
4.527E-1
 1 49
11 1q32 1q32 2.515E-2 4.115E-2
1.438E-1
4.527E-1
 1 49
12 5q13.2 5q13.2 2.869E-2 4.304E-2
1.504E-1
5.165E-1
 1 56
Show 7 more annotations

11: Transcription Factor Binding Site [Display Chart] 15 input genes in category / 156 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$E2F Q6 01 V$E2F Q6 01 5.782E-6 9.020E-4 5.078E-3 9.020E-4 5 184
2 V$E2F Q4 01 V$E2F Q4 01 1.443E-4 1.125E-2
6.336E-2
 2.251E-2 4 185
3 V$MYCMAX B V$MYCMAX B 2.713E-4 1.411E-2
7.943E-2
 4.232E-2 4 218
4 TTCNRGNNNNTTC V$HSF Q6 TTCNRGNNNNTTC V$HSF Q6 6.857E-4 2.674E-2
1.506E-1
1.070E-1
 3 117

12: Gene Family [Display Chart] 11 input genes in category / 7 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 596 Armadillo repeat containing|Importins genenames.org 8.013E-20 5.609E-19 1.454E-18 5.609E-19 7 18
2 409 Armadillo repeat containing genenames.org 2.650E-11 9.277E-11 2.405E-10 1.855E-10 5 43
3 547 Exportins genenames.org 6.967E-6 1.626E-5 4.215E-5 4.877E-5 2 7
4 769 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 2.099E-3 3.673E-3 9.523E-3 1.469E-2 2 115
5 909 Tetratricopeptide repeat domain containing|Cyclophilin peptidylprolyl isomerases genenames.org 1.143E-2 1.473E-2 3.820E-2
8.001E-2
 1 19
6 89 Zinc fingers RANBP2-type genenames.org 1.263E-2 1.473E-2 3.820E-2
8.839E-2
 1 21
7 1051 Nucleoporins genenames.org 1.918E-2 1.918E-2 4.974E-2
1.343E-1
 1 32
Show 2 more annotations

13: Coexpression [Display Chart] 18 input genes in category / 1673 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M7185 Genes up-regulated in transitional CR2 [GeneID=1380] high B lymphocytes versus those from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 3.590E-7 6.005E-4 4.804E-3 6.005E-4 5 200
2 16919171-Table3 Human Colon Ancona06 45genes GeneSigDB 4.453E-6 2.126E-3 1.701E-2 7.450E-3 3 42
3 M2536 Proteins interacting with AIRE [GeneID=326], based on massspectroscopy analysis of co-immunoprecipitates in 293T cells (embryonic kidney). MSigDB C2: CGP Curated Gene Sets (v6.0) 5.496E-6 2.126E-3 1.701E-2 9.196E-3 3 45
4 18427120-DataS4 Human Breast Crawford08 971genes GeneSigDB 6.433E-6 2.126E-3 1.701E-2 1.076E-2 5 360
5 M6387 Genes from the 254-gene classifier which were up-regulated in melanoma patients with a reported distant metastasis within 4 years. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.564E-6 2.126E-3 1.701E-2 1.098E-2 4 162
6 15308739-Table1 Human Viral Krishnan04 59genes GeneSigDB 8.531E-6 2.126E-3 1.701E-2 1.427E-2 3 52
7 M1913 Genes down-regulated in neural stem cells (NSC) at 36 h after cre-lox knockout of TLX (NR2E1) [GeneID=7101]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.109E-5 2.126E-3 1.701E-2 1.856E-2 4 185
8 M9475 Genes down-regulated in CD8 T cells: naïve versus effectors. MSigDB C7: Immunologic Signatures (v6.0) 1.478E-5 2.126E-3 1.701E-2 2.473E-2 4 199
9 M5901 Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. MSigDB H: Hallmark Gene Sets (v6.0) 1.508E-5 2.126E-3 1.701E-2 2.523E-2 4 200
10 M5926 A subgroup of genes regulated by MYC - version 1 (v1). MSigDB H: Hallmark Gene Sets (v6.0) 1.508E-5 2.126E-3 1.701E-2 2.523E-2 4 200
11 M5925 Genes encoding cell cycle related targets of E2F transcription factors. MSigDB H: Hallmark Gene Sets (v6.0) 1.508E-5 2.126E-3 1.701E-2 2.523E-2 4 200
12 17410534-Table1 Human Breast Klein07 63genes human Mouse GeneSigDB 1.525E-5 2.126E-3 1.701E-2 2.551E-2 3 63
13 17150101-TableS1a Human Breast Troester06 81genes up sham HME-CC GeneSigDB 2.006E-5 2.581E-3 2.065E-2 3.356E-2 3 69
14 16265353-SuppTable2 Human Bladder Aaboe05 86genes GeneSigDB 2.377E-5 2.840E-3 2.272E-2 3.976E-2 3 73
15 M15606 Genes up-regulated in adult fibroblasts with inactivated RB1 [GeneID=5925] by Cre-lox: acute loss of function (LOF) of RB1. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.838E-5 3.166E-3 2.533E-2 4.749E-2 4 235
16 19074895-Table3 Human Liver Sakai08 86genes GeneSigDB 3.369E-5 3.412E-3 2.730E-2
5.637E-2
 3 82
17 M9224 Selected genes up-regulated in peripheral blood monocytes (PBMC) of patients with hepatocellular carcinoma (HCC) compared to those with chronic hepatitis. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.494E-5 3.412E-3 2.730E-2
5.845E-2
 3 83
18 M16010 Genes down-regulated in H1975 cells (non-small cell lung cancer, NSCLC) resistant to gefitinib [PubChem=123631] after treatment with EGFR inhibitor CL-387785 [PubChem=2776] for 24h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.671E-5 3.412E-3 2.730E-2
6.142E-2
 4 251
19 12874028-Table1 Human Esophagus Barrett03 104genes GeneSigDB 5.233E-5 4.608E-3 3.686E-2
8.754E-2
 3 95
20 M2849 Genes down-regulated in SK-NEP-1 cells (Wilm's tumor ) stably expressing inactivated forms of STAT1 [GeneID=6772] under growth stress (hypoxia or nutritional deprivation). MSigDB C2: CGP Curated Gene Sets (v6.0) 6.816E-5 5.430E-3 4.344E-2
1.140E-1
 2 16
21 19266279-Table1 Human Breast Chen09 16genes GeneSigDB 6.816E-5 5.430E-3 4.344E-2
1.140E-1
 2 16
22 M1215 Selected up-regulated genes distinguishing between Wilms tumors of different histological types: anaplastic vs favorable histology. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.699E-5 7.133E-3
5.706E-2
1.623E-1
 2 19
23 15171711-Table1 Human Breast Cicatiello04 344genes GeneSigDB 1.049E-4 7.133E-3
5.706E-2
1.756E-1
 4 329
24 M6866 Genes down-regulated in PaCa44 and CFPAC1 cells (pancreatic cancer) after treatment with decitabine [PubChem=451668], a DNA hypomethylating agent similar to azacitidine [PubChem=9444]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.102E-4 7.133E-3
5.706E-2
1.843E-1
 3 122
25 M17094 Genes down-regulated in non-metastatic breast cancer tumors having type 1 amplification in the 20q13 region; involves ZNF217 [GeneID=7764] locus only. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.112E-4 7.133E-3
5.706E-2
1.861E-1
 4 334
26 M7079 The 'core ESC-like gene module': genes coordinately up-regulated in a compendium of mouse embryonic stem cells (ESC) which are shared with the human ESC-like module. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.125E-4 7.133E-3
5.706E-2
1.882E-1
 4 335
27 M13936 Genes down-regulated in BJAB cells (B-lymphoma) after glutamine [PubChem=738] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.151E-4 7.133E-3
5.706E-2
1.926E-1
 4 337
28 M2366 Genes up-regulated in HEK-293 cells (fibroblast) upon knockdown of CTBP1 but not of SATB1 [GeneID=1487, 6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.232E-4 7.327E-3
5.861E-2
2.061E-1
 4 343
29 M2608 Cell cycle genes significantly (p =< 0.05) changed in fibroblast cells at 24 h after exposure to ionizing radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.270E-4 7.327E-3
5.861E-2
2.125E-1
 3 128
30 17899371-25GeneList Human Breast Lauss08 25genes GeneSigDB 1.562E-4 8.710E-3
6.968E-2
2.613E-1
 2 24
31 18427120-DataS5 Human Breast Crawford08 187genes GeneSigDB 1.691E-4 8.711E-3
6.968E-2
2.828E-1
 3 141
32 15531917-Table2 Human Kidney Li05 28genes GeneSigDB 1.697E-4 8.711E-3
6.968E-2
2.839E-1
 2 25
33 M1865 Up-regulated genes in the subpopulation of invasive PyMT cells (breast cancer) compared to the general population of PyMT cells. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.718E-4 8.711E-3
6.968E-2
2.874E-1
 4 374
34 M10175 Genes down-regulated in MCF7 cells (breast cancer) under hypoxia conditions. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.874E-4 9.220E-3
7.376E-2
3.135E-1
 3 146
35 M3766 Up-regulated genes whose expression correlated with histologic grade of invasive breast cancer tumors: comparison of grade 1 vs grade 3. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.069E-4 9.891E-3
7.913E-2
3.462E-1
 3 151
36 12925741-Figure8 Human Lymphoma Jenner03 279genes GeneSigDB 2.151E-4 9.996E-3
7.997E-2
3.599E-1
 3 153
37 M4399 Up-regulated in MCF7 cells (breast cancer) by TLX1 (HOX11) [GeneID=3195]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.534E-4 1.141E-2
9.127E-2
4.239E-1
 4 414
38 M5588 Genes up-regulated during differentiation from large pre-BII to small pre-BII lymphocyte. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.591E-4 1.141E-2
9.127E-2
4.336E-1
 3 163
39 M1930 Genes from the yellow module which are up-regulated in HAEC cells (primary aortic endothelium) after exposure to the oxidized 1-palmitoyl-2-arachidonyl-sn-3-glycerophosphorylcholine (oxPAPC). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.796E-4 1.144E-2
9.151E-2
4.678E-1
 2 32
40 M13893 Genes down-regulated in Daudi cells (B lymphocytes) stably expressing CD5 [GeneID=921] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.954E-4 1.144E-2
9.151E-2
4.941E-1
 4 431
41 M2639 Genes up-regulated in granule cell neuron precursors (GCNPs) after stimulation with Shh for 3h. MSigDB C6: Oncogenic Signatures (v6.0) 3.139E-4 1.144E-2
9.151E-2
5.252E-1
 3 174
42 M2367 Genes down-regulated in HEK-293 cells (fibroblast) upon knockdown of CTBP1 but not of SATB1 [GeneID=1487, 6304] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.307E-4 1.144E-2
9.151E-2
5.532E-1
 4 444
43 16293602-Table1 Mouse StemCell Kamminga06 56genes GeneSigDB 3.350E-4 1.144E-2
9.151E-2
5.604E-1
 2 35
44 M3155 Genes up-regulated in quiescent CD34+ [GeneID=8842] cells isolated from peripheral blood of normal donors compared to the dividing cells from CML (chronic myeloid leukemia) patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.524E-4 1.144E-2
9.151E-2
5.895E-1
 3 181
45 M2076 Genes periodically expressed in synchronized HeLa cells (cervical carcinoma), with peak during the G2 phase of cell cycle. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.581E-4 1.144E-2
9.151E-2
5.991E-1
 3 182
46 M367 Genes down-regulated in macrophages differentiated in the presence of IL4 [GeneID=3565] for 5 days versus those subsequently treated with TGFB1 [GeneID=7040] for 24h. MSigDB C7: Immunologic Signatures (v6.0) 3.757E-4 1.144E-2
9.151E-2
6.285E-1
 3 185
47 M12104 Genes down-regulated in BJAB cells (B-lymphoma) after leucine [PubChem=857] deprivation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.877E-4 1.144E-2
9.151E-2
6.486E-1
 3 187
48 M6819 Genes up-regulated in dendritic cells: untreated versus inflammatory cytokine cocktail. MSigDB C7: Immunologic Signatures (v6.0) 3.938E-4 1.144E-2
9.151E-2
6.588E-1
 3 188
49 M2632 Genes up-regulated in mouse fibroblasts over-expressing E2F1 [Gene ID=1869] gene. MSigDB C6: Oncogenic Signatures (v6.0) 3.938E-4 1.144E-2
9.151E-2
6.588E-1
 3 188
50 15171711-Table6 Human Breast Cicatiello04 51genes ER GeneSigDB 4.164E-4 1.144E-2
9.151E-2
6.967E-1
 2 39
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 634 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U/Kidney Normal fetal kidney R-U/Kidney Normal fetal kidney R10 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R-U/Kidney Normal fetal kidney R-U/Kidney Normal fetal kidney R10 Adult, Development, and Cancer types 1.793E-5 8.442E-3
5.935E-2
 1.137E-2 2 8
2 Lungmap Mouse Lung E16.5 Proliferative fibroblast Lungmap Mouse Lung E16.5 Proliferative fibroblast Lungmap CCHMC 2.663E-5 8.442E-3
5.935E-2
 1.688E-2 5 456
3 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor E16.5 Top 200 Genes 1.757E-4 2.091E-2
1.470E-1
1.114E-1
 4 355
4 Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Fibroblast Subtype Early Fibroblastic Progenitor Top 200 Genes 1.757E-4 2.091E-2
1.470E-1
1.114E-1
 4 355
5 GSM791154 500 alpha beta T cells, T.DN4.Th, Lin-/lo CD25- CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.189E-4 2.091E-2
1.470E-1
1.388E-1
 4 376
6 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.2 Top 100 Genes 2.406E-4 2.091E-2
1.470E-1
1.525E-1
 3 150
7 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.1 Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Subtype int.01.1 Top 100 Genes 2.453E-4 2.091E-2
1.470E-1
1.555E-1
 3 151
8 GSM791143 500 alpha beta T cells, preT.DN3-4.Th, Lin-/lo CD25int CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 2.694E-4 2.091E-2
1.470E-1
1.708E-1
 4 397
9 GSM791149 500 alpha beta T cells, preT.DN3B.Th, Lin-/lo CD25hi CD44- CD28+, Thymus, avg-3 Immgen.org, GSE15907 3.131E-4 2.091E-2
1.470E-1
1.985E-1
 4 413
10 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Astrocytoma/3/1 Sample Type by Project: Shred 1/TCGA-Brain/Low Grade Glioma/Astrocytoma/3/1 TCGA-Brain 3.298E-4 2.091E-2
1.470E-1
2.091E-1
 3 167
11 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/common lymphoid progenitor Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/common lymphoid progenitor Tabula Muris Consortium 4.810E-4 2.493E-2
1.752E-1
3.050E-1
 3 190
12 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Skin/stem cell of epidermis Tabula Muris Consortium 4.884E-4 2.493E-2
1.752E-1
3.097E-1
 3 191
13 Cap mesenchyme (CM) Cap mesenchyme (CM) 5.111E-4 2.493E-2
1.752E-1
3.241E-1
 3 194
14 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 Human Cell Atlas Human Cell Atlas Immune Immune Top 200 5.705E-4 2.501E-2
1.758E-1
3.617E-1
 4 484
15 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K5 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#5 FaceBase_RNAseq 5.917E-4 2.501E-2
1.758E-1
3.751E-1
 3 204
16 Lungmap Mouse Lung PND1 Endothelial Subtype Primitive Proliferative Endothelial Lungmap Mouse Lung PND1 Endothelial Subtype Primitive Proliferative Endothelial Lungmap CCHMC 7.368E-4 2.920E-2
2.053E-1
4.672E-1
 3 220
17 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 500 K5 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 500 k-means-cluster#5 FaceBase_RNAseq 8.702E-4 3.245E-2
2.281E-1
5.517E-1
 3 233
18 Lungmap Mouse Lung PND3 MatrixFB Subtype MatrixFB-C Lungmap Mouse Lung PND3 MatrixFB Subtype MatrixFB-C Lungmap CCHMC 1.079E-3 3.800E-2
2.671E-1
6.839E-1
 3 251
19 Lungmap Mouse Lung PND3 Immune Subtype Immune-C Lungmap Mouse Lung PND3 Immune Subtype Immune-C Lungmap CCHMC 1.331E-3 4.115E-2
2.893E-1
8.437E-1
 3 270
20 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPM Top 40 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPM Top 40 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.417E-3 4.115E-2
2.893E-1
8.981E-1
 2 68
21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter MNP1-like Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter MNP1-like Adult, Development, and Cancer types 1.630E-3 4.115E-2
2.893E-1
1.000E0
 2 73
22 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-A Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-A Lungmap CCHMC 1.699E-3 4.115E-2
2.893E-1
1.000E0
 3 294
23 Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D Lungmap Mouse Lung PND3 Endothelial Subtype Endothelial-D Lungmap CCHMC 1.765E-3 4.115E-2
2.893E-1
1.000E0
 3 298
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Pelvis Wilms NK cell/Kidney Normal-Pelvis Wilms NK6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Pelvis Wilms NK cell/Kidney Normal-Pelvis Wilms NK6 Adult, Development, and Cancer types 1.812E-3 4.115E-2
2.893E-1
1.000E0
 2 77
25 Human Cell Atlas Human Cell Atlas B cell B cell Subtype CD34+ pre-B cycling Top 200 Genes Human Cell Atlas Human Cell Atlas B cell B cell Subtype CD34+ pre-B cycling Top 200 Genes 1.869E-3 4.115E-2
2.893E-1
1.000E0
 3 304
26 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ pre-T Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ pre-T Top 200 Genes 1.976E-3 4.115E-2
2.893E-1
1.000E0
 3 310
27 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC hProg Subtype hProgFPL Top 200 Genes GSE76381_EmbryoMoleculeCountsPMLog2 1.994E-3 4.115E-2
2.893E-1
1.000E0
 3 311
28 Facebase RNAseq e8.5 Hind Brain Neural Epithelium 1000 K4 FacebaseRNAseq e8.5 Hind Brain Neural Epithelium top-relative-expression-ranked 1000 k-means-cluster#4 FaceBase_RNAseq 2.068E-3 4.115E-2
2.893E-1
1.000E0
 3 315
29 Facebase RNAseq e9.5 Mandibular Arch 2500 K3 FacebaseRNAseq e9.5 Mandibular Arch top-relative-expression-ranked 2500 k-means-cluster#3 FaceBase_RNAseq 2.068E-3 4.115E-2
2.893E-1
1.000E0
 3 315
30 BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neurogenesis.neurons.immature.Sox4 Neurogenesis.neurons.immature.Sox4 Subtype Neurogenesis.neurons.immature.Sox4.Hist1h2al Top 200 Genes BrainMap 2.163E-3 4.115E-2
2.893E-1
1.000E0
 3 320
31 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Subtype Sox4.Hist1h2al Top 200 Genes 2.163E-3 4.115E-2
2.893E-1
1.000E0
 3 320
32 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neurogenesis Top 200 2.163E-3 4.115E-2
2.893E-1
1.000E0
 3 320
33 Facebase RNAseq e10.5 Neural Epithelium Overlying Lateral Eminence 1000 K2 FacebaseRNAseq e10.5 Neural Epithelium Overlying Lateral Eminence top-relative-expression-ranked 1000 k-means-cluster#2 FaceBase_RNAseq 2.320E-3 4.115E-2
2.893E-1
1.000E0
 3 328
34 10X Human 8K PBMC unknown Subtype unknown-T cells CD8 - D CCL5 positive Top 200 Genes 10X Human 8K PBMC unknown Subtype unknown-T cells CD8 - D CCL5 positive Top 200 Genes 2.320E-3 4.115E-2
2.893E-1
1.000E0
 3 328
35 Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte E E16.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte E E16.5 Top 200 Genes 2.340E-3 4.115E-2
2.893E-1
1.000E0
 3 329
36 Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte A Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte A Top 200 Genes 2.340E-3 4.115E-2
2.893E-1
1.000E0
 3 329
37 GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2a Top 200 Genes GSE7638 Midbrain human neurons vs stem cell-derived neurons Platform BrainMap - FluidigmC eProg Subtype eProg2a Top 200 Genes GSE76381_ESMoleculeCountsPMLog2 2.401E-3 4.115E-2
2.893E-1
1.000E0
 3 332
38 Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes Human Cell Atlas Human Cell Atlas Immune Immune Subtype CD34+ CLP Top 200 Genes 2.526E-3 4.215E-2
2.963E-1
1.000E0
 3 338
39 gudmap kidney e10.5 UretericTip HoxB7 k4 1000 kidney e10.5 UretericTip HoxB7 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.744E-3 4.461E-2
3.136E-1
1.000E0
 3 348
40 6mo cortical organoids wt 6mo cortical organoids wt pan subtypes mature neuron 1 Overall Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt pan subtypes mature neuron 1 Overall Top 100 Genes 2.855E-3 4.525E-2
3.181E-1
1.000E0
 2 97
41 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Overall Top 100 Genes 6mo cortical organoids wt 6mo cortical organoids wt Intermediate.0 Intermediate.0 Overall Top 100 Genes 2.971E-3 4.595E-2
3.230E-1
1.000E0
 2 99
42 10X Human 8K PBMC doublet Subtype doublet-T cells CD8 - D CCL5 positive Top 200 Genes 10X Human 8K PBMC doublet Subtype doublet-T cells CD8 - D CCL5 positive Top 200 Genes 3.115E-3 4.703E-2
3.306E-1
1.000E0
 3 364
Show 37 more annotations

15: Computational [Display Chart] 16 input genes in category / 148 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M11473 MODULE 352 Nuclear pore complex. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.924E-14 1.025E-11 5.716E-11 1.025E-11 6 17
2 M19205 MODULE 245 Genes in the cancer module 245. MSigDb: C4 - CM: Cancer Modules (v6.0) 6.304E-8 4.665E-6 2.602E-5 9.330E-6 4 26
3 M3370 MODULE 155 Genes in the cancer module 155. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.483E-6 3.692E-4 2.059E-3 1.108E-3 3 25
4 M14843 MODULE 98 Genes in the cancer module 98. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.740E-4 1.014E-2
5.655E-2
 4.055E-2 5 393
5 M14316 MODULE 392 rRNA processing and DNA repair. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.591E-4 1.063E-2
5.930E-2
5.315E-2
 2 18
6 M5468 MODULE 54 Cell cycle (expression cluster). MSigDb: C4 - CM: Cancer Modules (v6.0) 6.446E-4 1.590E-2
8.869E-2
9.540E-2
 4 262
7 M17658 MODULE 198 Genes in the cancer module 198. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.112E-3 2.350E-2
1.311E-1
1.645E-1
 4 303
Show 2 more annotations

16: MicroRNA [Display Chart] 18 input genes in category / 1296 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-483-3p:PITA hsa-miR-483-3p:PITA TOP PITA 1.422E-8 1.285E-5 9.952E-5 1.843E-5 4 108
2 hsa-miR-483-3p.2:TargetScan hsa-miR-483-3p.2 TargetScan 2.483E-8 1.285E-5 9.952E-5 3.218E-5 4 124
3 hsa-miR-181b-5p:Functional MTI Functional MTI miRTarbase 2.975E-8 1.285E-5 9.952E-5 3.855E-5 5 375
4 hsa-miR-7-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.037E-8 1.656E-5 1.283E-4 1.171E-4 4 171
5 hsa-miR-320c:PITA hsa-miR-320c:PITA TOP PITA 1.022E-7 1.656E-5 1.283E-4 1.325E-4 5 481
6 hsa-miR-320d:PITA hsa-miR-320d:PITA TOP PITA 1.022E-7 1.656E-5 1.283E-4 1.325E-4 5 481
7 hsa-miR-320b:PITA hsa-miR-320b:PITA TOP PITA 1.022E-7 1.656E-5 1.283E-4 1.325E-4 5 481
8 hsa-miR-320a:PITA hsa-miR-320a:PITA TOP PITA 1.022E-7 1.656E-5 1.283E-4 1.325E-4 5 481
9 hsa-miR-7-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.212E-7 1.745E-5 1.352E-4 1.571E-4 4 184
10 AGGAGTG,MIR-483:MSigDB AGGAGTG,MIR-483:MSigDB MSigDB 5.109E-7 6.622E-5 5.128E-4 6.622E-4 3 63
11 hsa-miR-1300:PITA hsa-miR-1300:PITA TOP PITA 6.294E-7 6.958E-5 5.389E-4 8.157E-4 4 278
12 hsa-miR-802:Functional MTI Functional MTI miRTarbase 6.443E-7 6.958E-5 5.389E-4 8.350E-4 3 68
13 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 2.086E-6 1.931E-4 1.496E-3 2.704E-3 4 376
14 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 2.086E-6 1.931E-4 1.496E-3 2.704E-3 4 376
15 hsa-miR-33b-5p:TargetScan hsa-miR-33b-5p TargetScan 2.638E-6 2.137E-4 1.655E-3 3.419E-3 4 399
16 hsa-miR-33a-5p:TargetScan hsa-miR-33a-5p TargetScan 2.638E-6 2.137E-4 1.655E-3 3.419E-3 4 399
17 hsa-miR-205-5p:TargetScan hsa-miR-205-5p TargetScan 3.201E-6 2.440E-4 1.890E-3 4.148E-3 4 419
18 hsa-miR-802:PITA hsa-miR-802:PITA TOP PITA 4.317E-6 3.075E-4 2.382E-3 5.595E-3 4 452
19 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 4.508E-6 3.075E-4 2.382E-3 5.843E-3 4 457
20 hsa-miR-3173-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.102E-6 3.306E-4 2.560E-3 6.612E-3 3 135
21 hsa-miR-6891-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.569E-6 3.437E-4 2.662E-3 7.217E-3 3 139
22 hsa-miR-5688:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.018E-5 5.996E-4 4.644E-3 1.319E-2 3 170
23 hsa-miR-17-3p:Functional MTI Functional MTI miRTarbase 1.073E-5 6.044E-4 4.681E-3 1.390E-2 3 173
24 hsa-miR-495-3p:Functional MTI Functional MTI miRTarbase 1.290E-5 6.794E-4 5.262E-3 1.671E-2 3 184
25 hsa-miR-584:PITA hsa-miR-584:PITA TOP PITA 1.311E-5 6.794E-4 5.262E-3 1.699E-2 3 185
26 hsa-miR-6886-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.613E-5 7.771E-4 6.019E-3 2.091E-2 2 24
27 hsa-miR-1301-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.630E-5 7.771E-4 6.019E-3 2.112E-2 3 199
28 hsa-miR-942-5p:Non-Functional MTI Non-Functional MTI miRTarbase 1.679E-5 7.771E-4 6.019E-3 2.176E-2 3 201
29 TTTTGAG,MIR-373:MSigDB TTTTGAG,MIR-373:MSigDB MSigDB 1.968E-5 8.744E-4 6.772E-3 2.551E-2 3 212
30 hsa-miR-361-5p:TargetScan hsa-miR-361-5p TargetScan 2.024E-5 8.744E-4 6.772E-3 2.623E-2 3 214
31 hsa-miR-643:PITA hsa-miR-643:PITA TOP PITA 2.350E-5 9.825E-4 7.609E-3 3.046E-2 3 225
32 hsa-miR-3924:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.883E-5 1.168E-3 9.044E-3 3.737E-2 3 241
33 hsa-miR-3662:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.332E-5 1.308E-3 1.013E-2 4.318E-2 3 253
34 hsa-miR-6850-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.472E-5 1.323E-3 1.025E-2 4.500E-2 2 35
35 hsa-miR-1827:PITA hsa-miR-1827:PITA TOP PITA 3.654E-5 1.323E-3 1.025E-2 4.736E-2 3 261
36 hsa-miR-374c-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.676E-5 1.323E-3 1.025E-2 4.763E-2 2 36
37 hsa-miR-891b:PITA hsa-miR-891b:PITA TOP PITA 3.953E-5 1.363E-3 1.056E-2
5.123E-2
 3 268
38 hsa-miR-618:PITA hsa-miR-618:PITA TOP PITA 3.997E-5 1.363E-3 1.056E-2
5.180E-2
 3 269
39 hsa-miR-515-5p:PITA hsa-miR-515-5p:PITA TOP PITA 6.504E-5 2.161E-3 1.674E-2
8.429E-2
 3 317
40 hsa-miR-1290:PITA hsa-miR-1290:PITA TOP PITA 8.939E-5 2.826E-3 2.188E-2
1.159E-1
 3 353
41 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 8.939E-5 2.826E-3 2.188E-2
1.159E-1
 3 353
42 hsa-miR-216a:PITA hsa-miR-216a:PITA TOP PITA 9.708E-5 2.996E-3 2.320E-2
1.258E-1
 3 363
43 hsa-miR-922:PITA hsa-miR-922:PITA TOP PITA 1.164E-4 3.507E-3 2.716E-2
1.508E-1
 3 386
44 GTTAAAG,MIR-302B:MSigDB GTTAAAG,MIR-302B:MSigDB MSigDB 1.208E-4 3.531E-3 2.735E-2
1.566E-1
 2 65
45 hsa-miR-2116-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.246E-4 3.531E-3 2.735E-2
1.615E-1
 2 66
46 hsa-miR-7151-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.302E-4 3.531E-3 2.735E-2
1.687E-1
 3 401
47 hsa-miR-5095:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.312E-4 3.531E-3 2.735E-2
1.700E-1
 3 402
48 hsa-miR-219a-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.362E-4 3.531E-3 2.735E-2
1.765E-1
 2 69
49 hsa-miR-199b-5p:TargetScan hsa-miR-199b-5p TargetScan 1.513E-4 3.531E-3 2.735E-2
1.961E-1
 3 422
50 hsa-miR-199a-5p:TargetScan hsa-miR-199a-5p TargetScan 1.513E-4 3.531E-3 2.735E-2
1.961E-1
 3 422
Show 45 more annotations

17: Drug [Display Chart] 18 input genes in category / 3890 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000435143 NSC-364372 Stitch 8.653E-21 3.366E-17 2.977E-16 3.366E-17 14 484
2 CID005326396 I-bB Stitch 2.079E-19 4.044E-16 3.576E-15 8.087E-16 9 62
3 CID000001896 AC1L1CH3 Stitch 1.114E-15 1.444E-12 1.277E-11 4.332E-12 8 85
4 CID004369512 AC1NA07U Stitch 2.802E-15 2.725E-12 2.410E-11 1.090E-11 8 95
5 CID005316801 dmDBP Stitch 4.044E-12 3.147E-9 2.783E-8 1.573E-8 4 6
6 CID005312573 Hcda Stitch 1.886E-11 1.222E-8 1.081E-7 7.335E-8 4 8
7 CID004318740 AC1N8H7N Stitch 2.342E-11 1.301E-8 1.151E-7 9.110E-8 6 78
8 CID000480142 Tat11 Stitch 3.392E-11 1.649E-8 1.459E-7 1.320E-7 4 9
9 CID000005297 NSC-14083 Stitch 1.467E-10 6.342E-8 5.608E-7 5.708E-7 7 210
10 CID000008447 MBTS Stitch 2.488E-10 9.678E-8 8.559E-7 9.678E-7 5 47
11 CID000011122 methyl-1,4-benzoquinone Stitch 3.431E-10 1.213E-7 1.073E-6 1.335E-6 5 50
12 CID000098207 Phe-gly Stitch 2.406E-9 7.800E-7 6.898E-6 9.360E-6 5 73
13 CID011069636 HYCRON linker Stitch 4.105E-9 1.141E-6 1.009E-5 1.597E-5 3 5
14 CID000073088 CNI-H0294 Stitch 4.105E-9 1.141E-6 1.009E-5 1.597E-5 3 5
15 CID000132237 TFPAM-6 Stitch 8.206E-9 1.995E-6 1.764E-5 3.192E-5 3 6
16 CID000480797 AC1LA3FM Stitch 8.206E-9 1.995E-6 1.764E-5 3.192E-5 3 6
17 ctd:D017373 Cyproterone Acetate CTD 1.392E-8 3.185E-6 2.816E-5 5.414E-5 4 35
18 CID000003862 mimosine Stitch 3.665E-8 7.921E-6 7.005E-5 1.426E-4 5 125
19 CID006432717 Ag I Stitch 5.593E-8 1.145E-5 1.013E-4 2.176E-4 4 49
20 CID004635684 AC1NE2UB Stitch 9.663E-8 1.879E-5 1.662E-4 3.759E-4 4 56
21 CID000024563 silver iodide Stitch 1.115E-7 2.066E-5 1.827E-4 4.338E-4 4 58
22 CID000001822 AC1L1CBF Stitch 1.577E-7 2.789E-5 2.467E-4 6.136E-4 6 337
23 CID011846801 NL-2 Stitch 3.328E-7 5.417E-5 4.791E-4 1.295E-3 3 18
24 CID000643956 7-chloro-DL-tryptophan Stitch 3.342E-7 5.417E-5 4.791E-4 1.300E-3 4 76
25 CID000002142 amikacin sulphate Stitch 1.228E-6 1.910E-4 1.689E-3 4.776E-3 4 105
26 958 DN resveratrol; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 9.581E-6 1.434E-3 1.268E-2 3.727E-2 4 176
27 CID000018835 Ebna Stitch 1.118E-5 1.610E-3 1.424E-2 4.347E-2 4 183
28 6921 UP H-89, Dihydrochloride; Up 200; 0.5uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.406E-5 1.744E-3 1.542E-2
5.471E-2
 4 194
29 578 DN DAPH; Down 200; 10uM; PC3; HG-U133A Broad Institute CMAP Down 1.435E-5 1.744E-3 1.542E-2
5.583E-2
 4 195
30 2196 DN Ethotoin [86-35-1]; Down 200; 19.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.464E-5 1.744E-3 1.542E-2
5.696E-2
 4 196
31 1735 DN Clorsulon [60200-06-8]; Down 200; 10.6uM; HL60; HG-U133A Broad Institute CMAP Down 1.464E-5 1.744E-3 1.542E-2
5.696E-2
 4 196
32 2544 DN Medrysone [2668-66-8]; Down 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.494E-5 1.744E-3 1.542E-2
5.812E-2
 4 197
33 CID000121907 EGTA-AM Stitch 1.510E-5 1.744E-3 1.542E-2
5.872E-2
 3 62
34 1564 DN Bupropion hydrochloride [31677-93-7]; Down 200; 14.4uM; HL60; HG-U133A Broad Institute CMAP Down 1.524E-5 1.744E-3 1.542E-2
5.929E-2
 4 198
35 ctd:C038753 leptomycin B CTD 2.572E-5 2.859E-3 2.528E-2
1.001E-1
 3 74
36 CID005327152 1 C2 Stitch 6.334E-5 6.845E-3
6.053E-2
2.464E-1
 3 100
37 CID000003641 hydrocortisone 21-acetate Stitch 6.525E-5 6.860E-3
6.067E-2
2.538E-1
 3 101
38 CID000444167 4-hydroxy-3-nitrophenylacetyl (NP) caproic Stitch 8.908E-5 9.118E-3
8.064E-2
3.465E-1
 2 18
39 CID005466602 GV Stitch 1.172E-4 1.169E-2
1.034E-1
4.560E-1
 3 123
40 ctd:C080163 trovafloxacin CTD 1.805E-4 1.755E-2
1.552E-1
7.021E-1
 4 374
41 ctd:D064704 Levofloxacin CTD 2.789E-4 1.850E-2
1.636E-1
1.000E0
 3 165
42 2777 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.097E-4 1.850E-2
1.636E-1
1.000E0
 3 171
43 2881 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.205E-4 1.850E-2
1.636E-1
1.000E0
 3 173
44 CID000065396 hypusine Stitch 3.242E-4 1.850E-2
1.636E-1
1.000E0
 2 34
45 3177 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.427E-4 1.850E-2
1.636E-1
1.000E0
 3 177
46 841 DN resveratrol; Down 200; 10uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 3.427E-4 1.850E-2
1.636E-1
1.000E0
 3 177
47 4710 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.484E-4 1.850E-2
1.636E-1
1.000E0
 3 178
48 6916 DN trichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.839E-4 1.850E-2
1.636E-1
1.000E0
 3 184
49 1835 DN Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; HL60; HT HG-U133A Broad Institute CMAP Down 3.839E-4 1.850E-2
1.636E-1
1.000E0
 3 184
50 3391 DN Monobenzone [103-16-2]; Down 200; 20uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.962E-4 1.850E-2
1.636E-1
1.000E0
 3 186
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 176 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C3280309 ARTHROGRYPOSIS, PERTHES DISEASE, AND UPWARD GAZE PALSY DisGeNET Curated 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
2 OMIN:608033 ENCEPHALOPATHY, ACUTE NECROTIZING 1, SUSCEPTIBILITY TO; ANE1 OMIM 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
3 cv:C2675556 Encephalopathy, acute, infection-induced, 3, suceptibility to Clinical Variations 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
4 C2675556 ENCEPHALOPATHY, ACUTE, INFECTION-INDUCED, SUSCEPTIBILITY TO, 3 DisGeNET Curated 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
5 C4048549 Malignant germ cell neoplasm DisGeNET BeFree 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
6 C0032541 Polyneuritis DisGeNET BeFree 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
7 C0432195 Short rib dysplasia DisGeNET BeFree 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
8 C0265987 Nevus comedonicus DisGeNET Curated 1.049E-3 2.308E-2
1.327E-1
1.846E-1
 1 1
9 C0018199 Granuloma, Plasma Cell DisGeNET Curated 2.097E-3 3.691E-2
2.122E-1
3.691E-1
 1 2
10 C1333967 Inflammatory pseudotumor of liver DisGeNET BeFree 2.097E-3 3.691E-2
2.122E-1
3.691E-1
 1 2
Show 5 more annotations