Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc172_14, positive side

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1: GO: Molecular Function [Display Chart] 14 input genes in category / 59 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0072509 divalent inorganic cation transmembrane transporter activity 1.120E-20 6.608E-19 3.082E-18 6.608E-19 11 173
2 GO:0005262 calcium channel activity 4.742E-20 1.399E-18 6.523E-18 2.798E-18 10 114
3 GO:0015085 calcium ion transmembrane transporter activity 2.167E-19 4.261E-18 1.987E-17 1.278E-17 10 132
4 GO:0005245 voltage-gated calcium channel activity 1.446E-18 2.134E-17 9.949E-17 8.534E-17 8 44
5 GO:0046873 metal ion transmembrane transporter activity 2.644E-16 3.120E-15 1.455E-14 1.560E-14 11 426
6 GO:0005261 cation channel activity 1.147E-15 1.128E-14 5.260E-14 6.767E-14 10 306
7 GO:0022836 gated channel activity 2.532E-15 2.134E-14 9.950E-14 1.494E-13 10 331
8 GO:0022843 voltage-gated cation channel activity 2.512E-14 1.853E-13 8.641E-13 1.482E-12 8 141
9 GO:0005216 ion channel activity 3.047E-14 1.998E-13 9.316E-13 1.798E-12 10 424
10 GO:0022838 substrate-specific channel activity 4.220E-14 2.490E-13 1.161E-12 2.490E-12 10 438
11 GO:0008331 high voltage-gated calcium channel activity 4.896E-14 2.626E-13 1.224E-12 2.888E-12 5 11
12 GO:0015267 channel activity 8.548E-14 3.963E-13 1.848E-12 5.043E-12 10 470
13 GO:0022803 passive transmembrane transporter activity 8.732E-14 3.963E-13 1.848E-12 5.152E-12 10 471
14 GO:0022832 voltage-gated channel activity 3.964E-13 1.559E-12 7.271E-12 2.339E-11 8 198
15 GO:0005244 voltage-gated ion channel activity 3.964E-13 1.559E-12 7.271E-12 2.339E-11 8 198
16 GO:0048763 calcium-induced calcium release activity 1.567E-6 5.780E-6 2.695E-5 9.247E-5 2 3
17 GO:0005219 ryanodine-sensitive calcium-release channel activity 3.133E-6 1.087E-5 5.071E-5 1.849E-4 2 4
18 GO:0086007 voltage-gated calcium channel activity involved in cardiac muscle cell action potential 5.220E-6 1.711E-5 7.979E-5 3.080E-4 2 5
19 GO:0005516 calmodulin binding 9.623E-6 2.988E-5 1.393E-4 5.678E-4 4 190
20 GO:0015278 calcium-release channel activity 6.234E-5 1.752E-4 8.168E-4 3.678E-3 2 16
21 GO:0099604 ligand-gated calcium channel activity 6.234E-5 1.752E-4 8.168E-4 3.678E-3 2 16
22 GO:0044325 ion channel binding 1.061E-4 2.845E-4 1.327E-3 6.258E-3 3 127
23 GO:0005217 intracellular ligand-gated ion channel activity 2.246E-4 5.763E-4 2.687E-3 1.325E-2 2 30
24 GO:0043924 suramin binding 7.502E-4 1.844E-3 8.600E-3 4.426E-2 1 1
25 GO:0017020 myosin phosphatase regulator activity 1.500E-3 3.540E-3 1.651E-2
8.850E-2
 1 2
26 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential 2.249E-3 5.104E-3 2.380E-2
1.327E-1
 1 3
27 GO:0016247 channel regulator activity 4.727E-3 1.033E-2 4.817E-2
2.789E-1
 2 139
28 GO:0022834 ligand-gated channel activity 5.341E-3 1.087E-2
5.067E-2
3.151E-1
 2 148
29 GO:0015276 ligand-gated ion channel activity 5.341E-3 1.087E-2
5.067E-2
3.151E-1
 2 148
30 GO:0019855 calcium channel inhibitor activity 7.479E-3 1.471E-2
6.859E-2
4.412E-1
 1 10
31 GO:0034236 protein kinase A catalytic subunit binding 1.120E-2 2.131E-2
9.939E-2
6.607E-1
 1 15
32 GO:0034237 protein kinase A regulatory subunit binding 1.194E-2 2.202E-2
1.027E-1
7.045E-1
 1 16
33 GO:0005385 zinc ion transmembrane transporter activity 1.712E-2 3.061E-2
1.428E-1
1.000E0
 1 23
34 GO:0051393 alpha-actinin binding 1.860E-2 3.228E-2
1.505E-1
1.000E0
 1 25
35 GO:0035255 ionotropic glutamate receptor binding 1.934E-2 3.260E-2
1.520E-1
1.000E0
 1 26
36 GO:0031369 translation initiation factor binding 2.595E-2 4.138E-2
1.930E-1
1.000E0
 1 35
37 GO:0051721 protein phosphatase 2A binding 2.595E-2 4.138E-2
1.930E-1
1.000E0
 1 35
38 GO:0042805 actinin binding 2.668E-2 4.143E-2
1.932E-1
1.000E0
 1 36
39 GO:0005246 calcium channel regulator activity 2.814E-2 4.258E-2
1.985E-1
1.000E0
 1 38
40 GO:0008200 ion channel inhibitor activity 2.887E-2 4.259E-2
1.986E-1
1.000E0
 1 39
41 GO:0016248 channel inhibitor activity 3.033E-2 4.364E-2
2.035E-1
1.000E0
 1 41
42 GO:0046915 transition metal ion transmembrane transporter activity 3.106E-2 4.364E-2
2.035E-1
1.000E0
 1 42
43 GO:0035254 glutamate receptor binding 3.397E-2 4.653E-2
2.170E-1
1.000E0
 1 46
44 GO:0051018 protein kinase A binding 3.470E-2 4.653E-2
2.170E-1
1.000E0
 1 47
Show 39 more annotations

2: GO: Biological Process [Display Chart] 14 input genes in category / 534 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0035637 multicellular organismal signaling 1.251E-22 6.679E-20 4.581E-19 6.679E-20 12 197
2 GO:0061337 cardiac conduction 4.861E-22 1.298E-19 8.901E-19 2.596E-19 11 131
3 GO:0008016 regulation of heart contraction 4.997E-19 8.895E-17 6.101E-16 2.669E-16 11 242
4 GO:0006816 calcium ion transport 8.335E-19 1.113E-16 7.631E-16 4.451E-16 12 405
5 GO:0070588 calcium ion transmembrane transport 1.772E-18 1.870E-16 1.283E-15 9.461E-16 11 271
6 GO:0060047 heart contraction 2.173E-18 1.870E-16 1.283E-15 1.160E-15 11 276
7 GO:0003015 heart process 2.452E-18 1.870E-16 1.283E-15 1.309E-15 11 279
8 GO:0070838 divalent metal ion transport 3.414E-18 2.193E-16 1.504E-15 1.823E-15 12 455
9 GO:0072511 divalent inorganic cation transport 3.697E-18 2.193E-16 1.504E-15 1.974E-15 12 458
10 GO:1903522 regulation of blood circulation 1.819E-17 9.715E-16 6.663E-15 9.715E-15 11 334
11 GO:0006874 cellular calcium ion homeostasis 1.818E-16 8.825E-15 6.053E-14 9.707E-14 11 411
12 GO:0055074 calcium ion homeostasis 2.634E-16 1.172E-14 8.039E-14 1.407E-13 11 425
13 GO:0072503 cellular divalent inorganic cation homeostasis 3.407E-16 1.399E-14 9.598E-14 1.819E-13 11 435
14 GO:0034765 regulation of ion transmembrane transport 5.601E-16 2.136E-14 1.465E-13 2.991E-13 11 455
15 GO:0072507 divalent inorganic cation homeostasis 6.023E-16 2.144E-14 1.471E-13 3.216E-13 11 458
16 GO:0034762 regulation of transmembrane transport 8.599E-16 2.870E-14 1.968E-13 4.592E-13 11 473
17 GO:0010959 regulation of metal ion transport 8.850E-13 2.780E-11 1.907E-10 4.726E-10 9 374
18 GO:0042391 regulation of membrane potential 1.320E-12 3.917E-11 2.687E-10 7.051E-10 9 391
19 GO:1904062 regulation of cation transmembrane transport 1.778E-12 4.998E-11 3.428E-10 9.496E-10 8 238
20 GO:0051924 regulation of calcium ion transport 2.102E-12 5.613E-11 3.850E-10 1.123E-9 8 243
21 GO:1903169 regulation of calcium ion transmembrane transport 2.660E-12 6.764E-11 4.639E-10 1.420E-9 7 133
22 GO:1901019 regulation of calcium ion transmembrane transporter activity 9.371E-12 2.275E-10 1.560E-9 5.004E-9 6 74
23 GO:0032412 regulation of ion transmembrane transporter activity 4.947E-11 1.149E-9 7.878E-9 2.642E-8 7 201
24 GO:0022898 regulation of transmembrane transporter activity 5.881E-11 1.309E-9 8.975E-9 3.140E-8 7 206
25 GO:0051899 membrane depolarization 7.591E-11 1.622E-9 1.112E-8 4.054E-8 6 104
26 GO:0032409 regulation of transporter activity 9.639E-11 1.980E-9 1.358E-8 5.147E-8 7 221
27 GO:0007528 neuromuscular junction development 2.233E-10 4.416E-9 3.029E-8 1.192E-7 5 50
28 GO:0050808 synapse organization 2.853E-10 5.441E-9 3.732E-8 1.524E-7 7 258
29 GO:0001508 action potential 4.245E-10 7.816E-9 5.361E-8 2.267E-7 6 138
30 GO:0007204 positive regulation of cytosolic calcium ion concentration 5.055E-10 8.998E-9 6.171E-8 2.699E-7 7 280
31 GO:0060402 calcium ion transport into cytosol 6.753E-10 1.163E-8 7.979E-8 3.606E-7 6 149
32 GO:0060401 cytosolic calcium ion transport 7.320E-10 1.222E-8 8.378E-8 3.909E-7 6 151
33 GO:0051480 regulation of cytosolic calcium ion concentration 9.391E-10 1.520E-8 1.042E-7 5.015E-7 7 306
34 GO:0070509 calcium ion import 2.043E-9 3.208E-8 2.200E-7 1.091E-6 6 179
35 GO:1901385 regulation of voltage-gated calcium channel activity 3.472E-9 5.297E-8 3.633E-7 1.854E-6 4 27
36 GO:2001257 regulation of cation channel activity 7.775E-9 1.153E-7 7.910E-7 4.152E-6 5 100
37 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel 2.833E-8 4.089E-7 2.805E-6 1.513E-5 3 9
38 GO:0098900 regulation of action potential 3.498E-8 4.916E-7 3.372E-6 1.868E-5 4 47
39 GO:0051238 sequestering of metal ion 3.942E-8 5.397E-7 3.702E-6 2.105E-5 5 138
40 GO:0006941 striated muscle contraction 8.531E-8 1.139E-6 7.811E-6 4.555E-5 5 161
41 GO:0006936 muscle contraction 1.079E-7 1.406E-6 9.642E-6 5.764E-5 6 348
42 GO:1903779 regulation of cardiac conduction 1.490E-7 1.895E-6 1.300E-5 7.959E-5 4 67
43 GO:0003012 muscle system process 3.757E-7 4.665E-6 3.200E-5 2.006E-4 6 430
44 GO:0086064 cell communication by electrical coupling involved in cardiac conduction 5.165E-7 6.268E-6 4.299E-5 2.758E-4 3 22
45 GO:0010644 cell communication by electrical coupling 9.788E-7 1.136E-5 7.793E-5 5.227E-4 3 27
46 GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 9.788E-7 1.136E-5 7.793E-5 5.227E-4 3 27
47 GO:1903514 release of sequestered calcium ion into cytosol by endoplasmic reticulum 1.357E-6 1.509E-5 1.035E-4 7.245E-4 3 30
48 GO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 1.357E-6 1.509E-5 1.035E-4 7.245E-4 3 30
49 GO:0051283 negative regulation of sequestering of calcium ion 1.561E-6 1.619E-5 1.111E-4 8.337E-4 4 120
50 GO:0051209 release of sequestered calcium ion into cytosol 1.561E-6 1.619E-5 1.111E-4 8.337E-4 4 120
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 14 input genes in category / 67 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0034704 calcium channel complex 7.276E-23 4.875E-21 2.335E-20 4.875E-21 10 63
2 GO:0005891 voltage-gated calcium channel complex 7.620E-22 2.553E-20 1.223E-19 5.105E-20 9 41
3 GO:0034703 cation channel complex 3.375E-18 7.537E-17 3.610E-16 2.261E-16 10 176
4 GO:0034702 ion channel complex 5.592E-16 9.367E-15 4.486E-14 3.747E-14 10 291
5 GO:1902495 transmembrane transporter complex 1.814E-15 2.431E-14 1.164E-13 1.215E-13 10 327
6 GO:1990351 transporter complex 2.179E-15 2.433E-14 1.165E-13 1.460E-13 10 333
7 GO:0016529 sarcoplasmic reticulum 4.012E-12 3.840E-11 1.839E-10 2.688E-10 6 66
8 GO:0016528 sarcoplasm 8.156E-12 6.831E-11 3.271E-10 5.464E-10 6 74
9 GO:0030315 T-tubule 5.106E-10 3.801E-9 1.820E-8 3.421E-8 5 60
10 GO:0042383 sarcolemma 6.635E-10 4.445E-9 2.129E-8 4.445E-8 6 152
11 GO:1990454 L-type voltage-gated calcium channel complex 6.300E-9 3.837E-8 1.838E-7 4.221E-7 3 6
12 GO:0033017 sarcoplasmic reticulum membrane 1.476E-8 8.239E-8 3.946E-7 9.886E-7 4 39
13 GO:0030314 junctional membrane complex 1.399E-5 7.211E-5 3.454E-4 9.374E-4 2 8
14 GO:0014701 junctional sarcoplasmic reticulum membrane 2.247E-5 1.075E-4 5.150E-4 1.505E-3 2 10
15 GO:0002095 caveolar macromolecular signaling complex 7.345E-4 3.281E-3 1.571E-2 4.921E-2 1 1
16 GO:0030018 Z disc 3.349E-3 1.402E-2
6.716E-2
2.244E-1
 2 119
17 GO:0005635 nuclear envelope 4.018E-3 1.583E-2
7.584E-2
2.692E-1
 3 454
18 GO:0031674 I band 4.285E-3 1.595E-2
7.639E-2
2.871E-1
 2 135
19 GO:0033018 sarcoplasmic reticulum lumen 5.862E-3 2.067E-2
9.900E-2
3.927E-1
 1 8
20 GO:0009898 cytoplasmic side of plasma membrane 6.631E-3 2.221E-2
1.064E-1
4.443E-1
 2 169
21 GO:0098562 cytoplasmic side of membrane 7.814E-3 2.493E-2
1.194E-1
5.236E-1
 2 184
22 GO:0030017 sarcomere 8.999E-3 2.741E-2
1.313E-1
6.030E-1
 2 198
23 GO:0044449 contractile fiber part 1.054E-2 3.070E-2
1.471E-1
7.062E-1
 2 215
24 GO:0030016 myofibril 1.101E-2 3.075E-2
1.473E-1
7.379E-1
 2 220
25 GO:0043292 contractile fiber 1.239E-2 3.321E-2
1.590E-1
8.302E-1
 2 234
26 GO:0031307 integral component of mitochondrial outer membrane 1.532E-2 3.948E-2
1.891E-1
1.000E0
 1 21
27 GO:0031306 intrinsic component of mitochondrial outer membrane 1.604E-2 3.981E-2
1.907E-1
1.000E0
 1 22
28 GO:0005640 nuclear outer membrane 1.821E-2 4.299E-2
2.059E-1
1.000E0
 1 25
29 GO:0031965 nuclear membrane 1.861E-2 4.299E-2
2.059E-1
1.000E0
 2 290
30 GO:0032281 AMPA glutamate receptor complex 2.182E-2 4.873E-2
2.334E-1
1.000E0
 1 30
Show 25 more annotations

4: Human Phenotype [Display Chart] 9 input genes in category / 395 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0004756 Ventricular tachycardia 2.003E-8 7.911E-6 5.188E-5 7.911E-6 5 54
2 HP:0001279 Syncope 3.756E-7 7.418E-5 4.864E-4 1.484E-4 5 96
3 HP:0001645 Sudden cardiac death 6.791E-7 8.941E-5 5.863E-4 2.682E-4 5 108
4 HP:0001663 Ventricular fibrillation 1.156E-6 1.126E-4 7.386E-4 4.566E-4 4 48
5 HP:0001695 Cardiac arrest 1.528E-6 1.126E-4 7.386E-4 6.034E-4 5 127
6 HP:0004308 Ventricular arrhythmia 1.783E-6 1.126E-4 7.386E-4 7.043E-4 5 131
7 HP:0001649 Tachycardia 1.996E-6 1.126E-4 7.386E-4 7.884E-4 5 134
8 HP:0005110 Atrial fibrillation 5.660E-6 2.641E-4 1.732E-3 2.236E-3 4 71
9 HP:0011704 Sick sinus syndrome 6.322E-6 2.641E-4 1.732E-3 2.497E-3 3 21
10 HP:0001692 Atrial arrhythmia 6.685E-6 2.641E-4 1.732E-3 2.641E-3 4 74
11 HP:0004755 Supraventricular tachycardia 9.141E-6 3.066E-4 2.011E-3 3.611E-3 4 80
12 HP:0007193 Generalized tonic-clonic seizures on awakening 9.742E-6 3.066E-4 2.011E-3 3.848E-3 2 3
13 HP:0005115 Supraventricular arrhythmia 1.009E-5 3.066E-4 2.011E-3 3.986E-3 4 82
14 HP:0011663 Right ventricular cardiomyopathy 2.116E-5 5.971E-4 3.915E-3 8.359E-3 3 31
15 HP:0006682 Ventricular extrasystoles 2.564E-5 6.751E-4 4.427E-3 1.013E-2 3 33
16 HP:0011702 Abnormal electrophysiology of sinoatrial node origin 2.809E-5 6.935E-4 4.547E-3 1.110E-2 3 34
17 HP:0002321 Vertigo 3.252E-5 7.555E-4 4.954E-3 1.284E-2 4 110
18 HP:0012003 Affective auras 4.856E-5 8.719E-4 5.718E-3 1.918E-2 2 6
19 HP:0012001 EEG with generalized polyspikes 4.856E-5 8.719E-4 5.718E-3 1.918E-2 2 6
20 HP:0012002 Experiential auras 4.856E-5 8.719E-4 5.718E-3 1.918E-2 2 6
21 HP:0011172 Complex febrile seizures 4.856E-5 8.719E-4 5.718E-3 1.918E-2 2 6
22 HP:0011175 Versive seizures 4.856E-5 8.719E-4 5.718E-3 1.918E-2 2 6
23 HP:0001751 Vestibular dysfunction 8.413E-5 1.429E-3 9.373E-3 3.323E-2 4 140
24 HP:0011167 Focal tonic seizures 9.047E-5 1.429E-3 9.373E-3 3.574E-2 2 8
25 HP:0012232 Shortened QT interval 9.047E-5 1.429E-3 9.373E-3 3.574E-2 2 8
26 HP:0001665 Abnormality of cardiac conduction 9.559E-5 1.452E-3 9.523E-3 3.776E-2 5 295
27 HP:0007000 Morning myoclonic jerks 1.162E-4 1.700E-3 1.115E-2 4.590E-2 2 9
28 HP:0001657 Prolonged QT interval 1.274E-4 1.737E-3 1.139E-2
5.032E-2
 3 56
29 HP:0031547 Abnormal QT interval 1.415E-4 1.737E-3 1.139E-2
5.591E-2
 3 58
30 HP:0011710 Bundle branch block 1.415E-4 1.737E-3 1.139E-2
5.591E-2
 3 58
31 HP:0002392 EEG with polyspike wave complexes 1.451E-4 1.737E-3 1.139E-2
5.732E-2
 2 10
32 HP:0011147 Typical absence seizure 1.451E-4 1.737E-3 1.139E-2
5.732E-2
 2 10
33 HP:0002131 Episodic ataxia 1.451E-4 1.737E-3 1.139E-2
5.732E-2
 2 10
34 HP:0011168 Eyelid myoclonias 2.124E-4 2.397E-3 1.572E-2
8.390E-2
 2 12
35 HP:0011169 Generalized clonic seizures 2.124E-4 2.397E-3 1.572E-2
8.390E-2
 2 12
36 HP:0011166 Focal myoclonic seizures 2.508E-4 2.752E-3 1.804E-2
9.906E-2
 2 13
37 HP:0003115 Abnormal EKG 3.169E-4 3.384E-3 2.219E-2
1.252E-1
 3 76
38 HP:0010850 EEG with spike-wave complexes 3.369E-4 3.493E-3 2.290E-2
1.331E-1
 2 15
39 HP:0500014 Abnormal test result 3.690E-4 3.493E-3 2.290E-2
1.457E-1
 3 80
40 HP:0500015 Abnormal cardiac test 3.690E-4 3.493E-3 2.290E-2
1.457E-1
 3 80
41 HP:0003114 Abnormal cardiological findings 3.690E-4 3.493E-3 2.290E-2
1.457E-1
 3 80
42 HP:0011675 Arrhythmia 3.714E-4 3.493E-3 2.290E-2
1.467E-1
 5 392
43 HP:0005141 Episodes of ventricular tachycardia 3.847E-4 3.534E-3 2.317E-2
1.519E-1
 2 16
44 HP:0030956 Abnormality of cardiovascular system electrophysiology 4.233E-4 3.660E-3 2.400E-2
1.672E-1
 5 403
45 HP:0005142 Atrioventricular nodal disease 4.263E-4 3.660E-3 2.400E-2
1.684E-1
 3 84
46 HP:0005150 Abnormal atrioventricular conduction 4.263E-4 3.660E-3 2.400E-2
1.684E-1
 3 84
47 HP:0011157 Focal sensory seizure 4.895E-4 4.114E-3 2.697E-2
1.933E-1
 2 18
48 HP:0011150 Myoclonic absence 5.465E-4 4.406E-3 2.889E-2
2.159E-1
 2 19
49 HP:0011148 Absence seizures with special features 5.465E-4 4.406E-3 2.889E-2
2.159E-1
 2 19
50 HP:0012722 Heart block 7.123E-4 5.591E-3 3.666E-2
2.814E-1
 3 100
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 14 input genes in category / 533 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0004145 abnormal muscle electrophysiology 5.616E-8 2.993E-5 2.052E-4 2.993E-5 4 30
2 MP:0009745 abnormal behavioral response to xenobiotic 1.501E-6 2.254E-4 1.545E-3 7.998E-4 6 304
3 MP:0000743 muscle spasm 2.041E-6 2.254E-4 1.545E-3 1.088E-3 4 72
4 MP:0009046 muscle twitch 2.405E-6 2.254E-4 1.545E-3 1.282E-3 4 75
5 MP:0000947 convulsive seizures 2.437E-6 2.254E-4 1.545E-3 1.299E-3 5 177
6 MP:0004994 abnormal brain wave pattern 2.537E-6 2.254E-4 1.545E-3 1.352E-3 4 76
7 MP:0000738 impaired muscle contractility 2.981E-6 2.270E-4 1.557E-3 1.589E-3 6 342
8 MP:0004088 abnormal sarcoplasmic reticulum morphology 3.429E-6 2.285E-4 1.567E-3 1.828E-3 3 23
9 MP:0002064 seizures 6.380E-6 3.779E-4 2.591E-3 3.401E-3 6 390
10 MP:0002906 increased susceptibility to pharmacologically induced seizures 1.112E-5 5.787E-4 3.968E-3 5.926E-3 4 110
11 MP:0012349 increased susceptibility to induction of seizure by inducing agent 1.194E-5 5.787E-4 3.968E-3 6.365E-3 4 112
12 MP:0005620 abnormal muscle contractility 1.380E-5 6.131E-4 4.204E-3 7.357E-3 6 446
13 MP:0003484 abnormal channel response 1.614E-5 6.618E-4 4.538E-3 8.603E-3 3 38
14 MP:0003216 absence seizures 1.887E-5 7.186E-4 4.927E-3 1.006E-2 3 40
15 MP:0000948 nonconvulsive seizures 2.700E-5 9.079E-4 6.225E-3 1.439E-2 3 45
16 MP:0000950 abnormal seizure response to pharmacological agent 2.725E-5 9.079E-4 6.225E-3 1.453E-2 4 138
17 MP:0002272 abnormal nervous system electrophysiology 7.530E-5 2.361E-3 1.619E-2 4.013E-2 5 359
18 MP:0009357 abnormal seizure response to inducing agent 1.053E-4 3.118E-3 2.138E-2
5.612E-2
 4 195
19 MP:0009538 abnormal synapse morphology 1.403E-4 3.935E-3 2.698E-2
7.477E-2
 4 210
20 MP:0003894 abnormal Purkinje cell innervation 1.530E-4 4.079E-3 2.797E-2
8.157E-2
 2 14
21 MP:0001408 stereotypic behavior 1.679E-4 4.261E-3 2.921E-2
8.947E-2
 4 220
22 MP:0003996 clonic seizures 2.015E-4 4.882E-3 3.347E-2
1.074E-1
 2 16
23 MP:0004087 abnormal muscle fiber morphology 2.403E-4 5.569E-3 3.818E-2
1.281E-1
 5 459
24 MP:0001053 abnormal neuromuscular synapse morphology 2.774E-4 6.161E-3 4.224E-2
1.479E-1
 3 98
25 MP:0001405 impaired coordination 3.019E-4 6.438E-3 4.414E-2
1.609E-1
 5 482
26 MP:0001051 abnormal somatic motor system morphology 3.213E-4 6.586E-3 4.516E-2
1.712E-1
 3 103
27 MP:0001824 abnormal thymus involution 4.226E-4 8.342E-3
5.720E-2
2.252E-1
 2 23
28 MP:0008840 abnormal spike wave discharge 4.606E-4 8.768E-3
6.012E-2
2.455E-1
 2 24
29 MP:0009453 enhanced contextual conditioning behavior 5.416E-4 9.843E-3
6.749E-2
2.886E-1
 2 26
30 MP:0001394 circling 5.540E-4 9.843E-3
6.749E-2
2.953E-1
 3 124
31 MP:0005202 lethargy 6.650E-4 1.143E-2
7.840E-2
3.545E-1
 3 132
32 MP:0002826 tonic seizures 7.226E-4 1.197E-2
8.208E-2
3.852E-1
 2 30
33 MP:0001523 impaired righting response 7.411E-4 1.197E-2
8.208E-2
3.950E-1
 3 137
34 MP:0001393 ataxia 8.609E-4 1.333E-2
9.137E-2
4.589E-1
 4 338
35 MP:0004835 abnormal miniature endplate potential 8.751E-4 1.333E-2
9.137E-2
4.664E-1
 2 33
36 MP:0000243 myoclonus 9.290E-4 1.376E-2
9.431E-2
4.952E-1
 2 34
37 MP:0003990 decreased neurotransmitter release 9.846E-4 1.418E-2
9.725E-2
5.248E-1
 2 35
38 MP:0002862 altered righting response 1.061E-3 1.488E-2
1.020E-1
5.654E-1
 3 155
39 MP:0002980 abnormal postural reflex 1.249E-3 1.591E-2
1.091E-1
6.656E-1
 3 164
40 MP:0004817 abnormal skeletal muscle mass 1.293E-3 1.591E-2
1.091E-1
6.893E-1
 3 166
41 MP:0001469 abnormal contextual conditioning behavior 1.293E-3 1.591E-2
1.091E-1
6.893E-1
 3 166
42 MP:0002841 impaired skeletal muscle contractility 1.351E-3 1.591E-2
1.091E-1
7.199E-1
 2 41
43 MP:0009559 thymus cortex hyperplasia 1.352E-3 1.591E-2
1.091E-1
7.206E-1
 1 1
44 MP:0020075 increased tyrosine 3-monooxygenase activity 1.352E-3 1.591E-2
1.091E-1
7.206E-1
 1 1
45 MP:0020076 increased brain tyrosine 3-monooxygenase activity 1.352E-3 1.591E-2
1.091E-1
7.206E-1
 1 1
46 MP:0012316 enhanced conditioning behavior 1.417E-3 1.591E-2
1.091E-1
7.553E-1
 2 42
47 MP:0005333 decreased heart rate 1.433E-3 1.591E-2
1.091E-1
7.636E-1
 3 172
48 MP:0004215 abnormal myocardial fiber physiology 1.433E-3 1.591E-2
1.091E-1
7.636E-1
 3 172
49 MP:0002913 abnormal PNS synaptic transmission 1.485E-3 1.615E-2
1.108E-1
7.915E-1
 2 43
50 MP:0000937 abnormal motor neuron morphology 1.794E-3 1.912E-2
1.311E-1
9.561E-1
 3 186
Show 45 more annotations

6: Domain [Display Chart] 14 input genes in category / 100 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR000584 VDCC L bsu InterPro 1.328E-9 6.640E-8 3.445E-7 1.328E-7 3 4
2 PF12052 VGCC beta4Aa N Pfam 1.328E-9 6.640E-8 3.445E-7 1.328E-7 3 4
3 SM00072 GuKc SMART 8.549E-7 1.196E-5 6.205E-5 8.549E-5 3 26
4 PF00625 Guanylate kin Pfam 8.549E-7 1.196E-5 6.205E-5 8.549E-5 3 26
5 IPR008145 GK/Ca channel bsu InterPro 8.549E-7 1.196E-5 6.205E-5 8.549E-5 3 26
6 IPR008144 Guanylate kin-like dom InterPro 8.549E-7 1.196E-5 6.205E-5 8.549E-5 3 26
7 IPR005821 Ion trans dom InterPro 1.242E-6 1.196E-5 6.205E-5 1.242E-4 4 114
8 PF00520 Ion trans Pfam 1.242E-6 1.196E-5 6.205E-5 1.242E-4 4 114
9 PF06459 RR TM4-6 Pfam 1.555E-6 1.196E-5 6.205E-5 1.555E-4 2 3
10 PF02026 RyR Pfam 1.555E-6 1.196E-5 6.205E-5 1.555E-4 2 3
11 IPR013333 Ryan recept InterPro 1.555E-6 1.196E-5 6.205E-5 1.555E-4 2 3
12 IPR009460 Ryanrecept TM4-6 InterPro 1.555E-6 1.196E-5 6.205E-5 1.555E-4 2 3
13 IPR003032 Ryanodine rcpt InterPro 1.555E-6 1.196E-5 6.205E-5 1.555E-4 2 3
14 PF08473 VGCC alpha2 Pfam 3.109E-6 2.072E-5 1.075E-4 3.109E-4 2 4
15 IPR013680 VDCC a2/dsu InterPro 3.109E-6 2.072E-5 1.075E-4 3.109E-4 2 4
16 PF08399 VWA N Pfam 5.179E-6 3.046E-5 1.580E-4 5.179E-4 2 5
17 IPR013608 VWA N InterPro 5.179E-6 3.046E-5 1.580E-4 5.179E-4 2 5
18 PF08709 Ins145 P3 rec Pfam 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
19 IPR014821 Ins145 P3 rcpt InterPro 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
20 1.25.10.30 - Gene3D 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
21 PF01365 RYDR ITPR Pfam 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
22 IPR015925 Ryanodine recept-rel InterPro 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
23 PF08454 RIH assoc Pfam 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
24 IPR000699 RIH dom InterPro 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
25 IPR013662 RIH assoc-dom InterPro 7.765E-6 3.106E-5 1.611E-4 7.765E-4 2 6
26 IPR014873 VDCC a1su IQ InterPro 1.087E-5 3.622E-5 1.879E-4 1.087E-3 2 7
27 IPR031649 GPHH dom InterPro 1.087E-5 3.622E-5 1.879E-4 1.087E-3 2 7
28 SM01062 Ca chan IQ SMART 1.087E-5 3.622E-5 1.879E-4 1.087E-3 2 7
29 PF08763 Ca chan IQ Pfam 1.087E-5 3.622E-5 1.879E-4 1.087E-3 2 7
30 PF16905 GPHH Pfam 1.087E-5 3.622E-5 1.879E-4 1.087E-3 2 7
31 PF02815 MIR Pfam 2.325E-5 6.644E-5 3.447E-4 2.325E-3 2 10
32 PS50919 MIR PROSITE 2.325E-5 6.644E-5 3.447E-4 2.325E-3 2 10
33 SM00472 MIR SMART 2.325E-5 6.644E-5 3.447E-4 2.325E-3 2 10
34 IPR002077 VDCCAlpha1 InterPro 2.325E-5 6.644E-5 3.447E-4 2.325E-3 2 10
35 IPR016093 MIR motif InterPro 2.325E-5 6.644E-5 3.447E-4 2.325E-3 2 10
36 IPR011992 EF-hand-dom pair InterPro 4.783E-5 1.329E-4 6.892E-4 4.783E-3 4 287
37 PF00036 EF-hand 1 Pfam 1.785E-4 4.824E-4 2.502E-3 1.785E-2 3 152
38 SM00326 SH3 SMART 5.076E-4 1.302E-3 6.752E-3
5.076E-2
 3 217
39 PS50002 SH3 PROSITE 5.076E-4 1.302E-3 6.752E-3
5.076E-2
 3 217
40 IPR001452 SH3 domain InterPro 5.354E-4 1.339E-3 6.944E-3
5.354E-2
 3 221
41 PS50222 EF HAND 2 PROSITE 6.091E-4 1.469E-3 7.618E-3
6.091E-2
 3 231
42 IPR002048 EF hand dom InterPro 6.168E-4 1.469E-3 7.618E-3
6.168E-2
 3 232
43 IPR005448 CACNA1A InterPro 7.473E-4 1.557E-3 8.076E-3
7.473E-2
 1 1
44 IPR008079 VDCC L b3su InterPro 7.473E-4 1.557E-3 8.076E-3
7.473E-2
 1 1
45 IPR005422 VDCC g2su InterPro 7.473E-4 1.557E-3 8.076E-3
7.473E-2
 1 1
46 IPR005443 VDCC L b1su InterPro 7.473E-4 1.557E-3 8.076E-3
7.473E-2
 1 1
47 IPR010798 Triadin InterPro 7.473E-4 1.557E-3 8.076E-3
7.473E-2
 1 1
48 IPR005451 VDCC L a1csu InterPro 7.473E-4 1.557E-3 8.076E-3
7.473E-2
 1 1
49 PF00092 VWA Pfam 7.804E-4 1.585E-3 8.222E-3
7.804E-2
 2 56
50 1.20.120.350 - Gene3D 8.084E-4 1.585E-3 8.222E-3
8.084E-2
 2 57
Show 45 more annotations

7: Pathway [Display Chart] 13 input genes in category / 126 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1339115 Cardiac conduction BioSystems: REACTOME 2.195E-20 2.765E-18 1.498E-17 2.765E-18 11 142
2 1268767 Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels BioSystems: REACTOME 3.198E-19 2.015E-17 1.092E-16 4.030E-17 7 13
3 1269868 Muscle contraction BioSystems: REACTOME 1.323E-18 5.556E-17 3.010E-16 1.667E-16 11 204
4 1339119 Phase 2 - plateau phase BioSystems: REACTOME 2.193E-16 6.907E-15 3.742E-14 2.763E-14 7 28
5 117293 Arrhythmogenic right ventricular cardiomyopathy (ARVC) BioSystems: KEGG 1.054E-15 2.656E-14 1.439E-13 1.328E-13 8 72
6 93344 Cardiac muscle contraction BioSystems: KEGG 2.060E-15 4.327E-14 2.344E-13 2.596E-13 8 78
7 952859 Oxytocin signaling pathway BioSystems: KEGG 3.459E-15 5.449E-14 2.952E-13 4.358E-13 9 153
8 114229 Hypertrophic cardiomyopathy (HCM) BioSystems: KEGG 3.460E-15 5.449E-14 2.952E-13 4.359E-13 8 83
9 121494 Dilated cardiomyopathy BioSystems: KEGG 6.782E-15 9.495E-14 5.144E-13 8.545E-13 8 90
10 1339117 Phase 0 - rapid depolarisation BioSystems: REACTOME 1.155E-14 1.456E-13 7.887E-13 1.456E-12 7 47
11 908257 Adrenergic signaling in cardiomyocytes BioSystems: KEGG 3.228E-13 3.698E-12 2.003E-11 4.067E-11 8 144
12 P04378 Beta2 adrenergic receptor signaling pathway PantherDB 1.989E-12 1.928E-11 1.044E-10 2.506E-10 6 43
13 P04377 Beta1 adrenergic receptor signaling pathway PantherDB 1.989E-12 1.928E-11 1.044E-10 2.506E-10 6 43
14 83048 MAPK signaling pathway BioSystems: KEGG 3.271E-11 2.944E-10 1.595E-9 4.122E-9 8 255
15 1268766 Transmission across Chemical Synapses BioSystems: REACTOME 7.196E-10 6.044E-9 3.274E-8 9.066E-8 7 218
16 1268763 Neuronal System BioSystems: REACTOME 1.978E-8 1.558E-7 8.440E-7 2.493E-6 7 351
17 1270313 NCAM1 interactions BioSystems: REACTOME 4.630E-8 3.432E-7 1.859E-6 5.834E-6 4 37
18 P04391 Oxytocin receptor mediated signaling pathway PantherDB 2.366E-7 1.656E-6 8.973E-6 2.981E-5 4 55
19 1339121 Ion homeostasis BioSystems: REACTOME 2.547E-7 1.689E-6 9.149E-6 3.209E-5 4 56
20 P04394 Thyrotropin-releasing hormone receptor signaling pathway PantherDB 2.938E-7 1.851E-6 1.003E-5 3.702E-5 4 58
21 P04374 5HT2 type receptor mediated signaling pathway PantherDB 4.113E-7 2.223E-6 1.204E-5 5.183E-5 4 63
22 SMP00298 Atenolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
23 SMP00301 Esmolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
24 SMP00297 Alprenolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
25 SMP00304 Oxprenolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
26 SMP00307 Propranolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
27 SMP00299 Betaxolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
28 SMP00366 Nebivolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
29 SMP00296 Acebutolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
30 SMP00306 Pindolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
31 SMP00303 Nadolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
32 SMP00305 Penbutolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
33 SMP00300 Bisoprolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
34 SMP00302 Metoprolol Pathway SMPDB 5.997E-7 2.223E-6 1.204E-5 7.557E-5 3 17
35 1270102 Regulation of insulin secretion BioSystems: REACTOME 1.081E-6 3.893E-6 2.109E-5 1.363E-4 4 80
36 SMP00368 Labetalol Pathway SMPDB 1.170E-6 3.985E-6 2.159E-5 1.474E-4 3 21
37 SMP00367 Carvedilol Pathway SMPDB 1.170E-6 3.985E-6 2.159E-5 1.474E-4 3 21
38 1270103 Adrenaline,noradrenaline inhibits insulin secretion BioSystems: REACTOME 2.870E-6 9.517E-6 5.156E-5 3.616E-4 3 28
39 1270101 Integration of energy metabolism BioSystems: REACTOME 4.022E-6 1.299E-5 7.040E-5 5.068E-4 4 111
40 83050 Calcium signaling pathway BioSystems: KEGG 2.850E-5 8.977E-5 4.863E-4 3.591E-3 4 182
41 698773 Circadian entrainment BioSystems: KEGG 1.201E-4 3.692E-4 2.000E-3 1.514E-2 3 96
42 1270312 NCAM signaling for neurite out-growth BioSystems: REACTOME 1.504E-4 4.369E-4 2.367E-3 1.896E-2 4 279
43 1269953 Stimuli-sensing channels BioSystems: REACTOME 1.524E-4 4.369E-4 2.367E-3 1.920E-2 3 104
44 PW:0000674 insulin secretion pathway Pathway Ontology 1.526E-4 4.369E-4 2.367E-3 1.922E-2 2 18
45 SMP00324 Procainamide (Antiarrhythmic) Pathway SMPDB 6.567E-4 1.532E-3 8.301E-3
8.274E-2
 2 37
46 SMP00332 Ibutilide Pathway SMPDB 6.567E-4 1.532E-3 8.301E-3
8.274E-2
 2 37
47 SMP00330 Tocainide Pathway SMPDB 6.567E-4 1.532E-3 8.301E-3
8.274E-2
 2 37
48 SMP00327 Phenytoin (Antiarrhythmic) Pathway SMPDB 6.567E-4 1.532E-3 8.301E-3
8.274E-2
 2 37
49 SMP00329 Mexiletine Pathway SMPDB 6.567E-4 1.532E-3 8.301E-3
8.274E-2
 2 37
50 SMP00326 Fosphenytoin (Antiarrhythmic) Pathway SMPDB 6.567E-4 1.532E-3 8.301E-3
8.274E-2
 2 37
Show 45 more annotations

8: Pubmed [Display Chart] 14 input genes in category / 2161 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 24453333 Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression. Pubmed 9.383E-22 1.014E-18 8.370E-18 2.028E-18 7 15
2 20188150 Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons. Pubmed 9.383E-22 1.014E-18 8.370E-18 2.028E-18 7 15
3 16985003 Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Pubmed 1.484E-19 1.069E-16 8.824E-16 3.207E-16 9 137
4 25798587 Ion channel expression in the developing enteric nervous system. Pubmed 1.350E-15 7.294E-13 6.022E-12 2.918E-12 6 36
5 19723630 Diversity and developmental expression of L-type calcium channel beta2 proteins and their influence on calcium current in murine heart. Pubmed 5.645E-14 2.440E-11 2.014E-10 1.220E-10 4 5
6 10328888 beta subunit reshuffling modifies N- and P/Q-type Ca2+ channel subunit compositions in lethargic mouse brain. Pubmed 1.693E-13 5.227E-11 4.315E-10 3.659E-10 4 6
7 10446746 Mouse models of spike-wave epilepsy. Pubmed 1.693E-13 5.227E-11 4.315E-10 3.659E-10 4 6
8 18809727 NCAM induces CaMKIIalpha-mediated RPTPalpha phosphorylation to enhance its catalytic activity and neurite outgrowth. Pubmed 3.721E-12 1.005E-9 8.298E-9 8.041E-9 4 11
9 11700294 Identification of epilepsy genes in human and mouse. Pubmed 5.580E-12 1.340E-9 1.106E-8 1.206E-8 4 12
10 15170217 Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
11 19422811 Loss of calcium channels in the cerebellum of the ataxic and epileptic stargazer mutant mouse. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
12 10515159 Single gene defects in mice: the role of voltage-dependent calcium channels in absence models. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
13 22737983 Regional expression and subcellular localization of the voltage-gated calcium channel β subunits in the developing mouse brain. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
14 17320843 Redundancy of Cav2.1 channel accessory subunits in transmitter release at the mouse neuromuscular junction. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
15 10469844 Ataxic mouse mutants and molecular mechanisms of absence epilepsy. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
16 12151514 Mutations in high-voltage-activated calcium channel genes stimulate low-voltage-activated currents in mouse thalamic relay neurons. Pubmed 3.920E-11 5.295E-9 4.371E-8 8.472E-8 3 3
17 19383796 Ablation of triadin causes loss of cardiac Ca2+ release units, impaired excitation-contraction coupling, and cardiac arrhythmias. Pubmed 1.568E-10 1.694E-8 1.399E-7 3.388E-7 3 4
18 19996312 Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons. Pubmed 1.568E-10 1.694E-8 1.399E-7 3.388E-7 3 4
19 10494839 Mutations of calcium channel beta subunit genes in mice. Pubmed 1.568E-10 1.694E-8 1.399E-7 3.388E-7 3 4
20 15175395 Role of the alpha1G T-type calcium channel in spontaneous absence seizures in mutant mice. Pubmed 1.568E-10 1.694E-8 1.399E-7 3.388E-7 3 4
21 8825650 Chromosomal localization of the human genes for alpha 1A, alpha 1B, and alpha 1E voltage-dependent Ca2+ channel subunits. Pubmed 3.919E-10 3.387E-8 2.797E-7 8.468E-7 3 5
22 19966779 Enhanced tonic GABAA inhibition in typical absence epilepsy. Pubmed 3.919E-10 3.387E-8 2.797E-7 8.468E-7 3 5
23 16787652 Identification of a cardiac isoform of the murine calcium channel alpha1C (Cav1.2-a) subunit and its preferential binding with the beta2 subunit. Pubmed 3.919E-10 3.387E-8 2.797E-7 8.468E-7 3 5
24 11980879 Role of the beta(2) subunit of voltage-dependent calcium channels in the retinal outer plexiform layer. Pubmed 3.919E-10 3.387E-8 2.797E-7 8.468E-7 3 5
25 21883149 A β-amyloid oligomer directly modulates P/Q-type calcium currents in Xenopus oocytes. Pubmed 3.919E-10 3.387E-8 2.797E-7 8.468E-7 3 5
26 10395577 Seizure disorders in mutant mice: relevance to human epilepsies. Pubmed 1.371E-9 1.139E-7 9.407E-7 2.963E-6 3 7
27 11784029 Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle. Pubmed 2.193E-9 1.755E-7 1.449E-6 4.739E-6 3 8
28 19095005 New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. Pubmed 8.608E-9 6.644E-7 5.485E-6 1.860E-5 3 12
29 11576544 Skeletal and cardiac ryanodine receptors bind to the Ca(2+)-sensor region of dihydropyridine receptor alpha(1C) subunit. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
30 11756409 Novel Cav2.1 splice variants isolated from Purkinje cells do not generate P-type Ca2+ current. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
31 25892515 Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channel. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
32 9293489 Pharmacological profiles of generalized absence seizures in lethargic, stargazer and gamma-hydroxybutyrate-treated model mice. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
33 10212211 A new beta subtype-specific interaction in alpha1A subunit controls P/Q-type Ca2+ channel activation. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
34 16928863 The calcium channel alpha2delta-2 subunit partitions with CaV2.1 into lipid rafts in cerebellum: implications for localization and function. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
35 9442082 A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel alpha 1A subunit. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
36 17028169 Critical role for the beta regulatory subunits of Cav channels in T lymphocyte function. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
37 14550562 The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
38 10322048 Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
39 21531043 Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
40 10627593 Presynaptic Ca(2+) influx at a mouse central synapse with Ca(2+) channel subunit mutations. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
41 24026422 Genetic interactions found between calcium channel genes modulate amyloid load measured by positron emission tomography. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
42 14500989 Structures of the murine genes for the beta1- and beta4-subunits of the voltage-dependent calcium channel. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
43 10670432 Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
44 8500431 Animal models of inherited epilepsy. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
45 8551348 Selective failure of brain-derived neurotrophic factor mRNA expression in the cerebellum of stargazer, a mutant mouse with ataxia. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
46 16914686 Aberrant GABA(A) receptor expression in the dentate gyrus of the epileptic mutant mouse stargazer. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
47 1370480 Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
48 25527503 Functional characterization of CaVα2δ mutations associated with sudden cardiac death. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
49 14985349 Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes. Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
50 20301674 Episodic Ataxia Type 2 Pubmed 1.248E-7 4.730E-6 3.905E-5 2.696E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 14 input genes in category / 333 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CACNB3 CACNB3 interactions 4.134E-13 1.377E-10 8.792E-10 1.377E-10 5 15
2 int:CACNB2 CACNB2 interactions 4.709E-8 7.841E-6 5.008E-5 1.568E-5 3 10
3 int:CACNB4 CACNB4 interactions 1.781E-7 1.977E-5 1.263E-4 5.932E-5 3 15
4 int:CACNB1 CACNB1 interactions 2.660E-7 2.214E-5 1.414E-4 8.857E-5 3 17
5 int:CACNA1B CACNA1B interactions 3.787E-7 2.522E-5 1.611E-4 1.261E-4 3 19
6 int:CACNA1C CACNA1C interactions 8.963E-7 4.975E-5 3.177E-4 2.985E-4 3 25
7 int:CACNA1A CACNA1A interactions 1.117E-6 5.315E-5 3.395E-4 3.721E-4 4 105
8 int:RYR2 RYR2 interactions 1.421E-6 5.916E-5 3.779E-4 4.733E-4 3 29
9 int:C7orf69 C7orf69 interactions 1.622E-5 6.000E-4 3.832E-3 5.400E-3 2 8
10 int:RYR3 RYR3 interactions 2.084E-5 6.940E-4 4.433E-3 6.940E-3 2 9
11 int:REM1 REM1 interactions 2.604E-5 7.226E-4 4.615E-3 8.671E-3 2 10
12 int:CBARP CBARP interactions 2.604E-5 7.226E-4 4.615E-3 8.671E-3 2 10
13 int:CABP1 CABP1 interactions 3.181E-5 8.149E-4 5.205E-3 1.059E-2 2 11
14 int:TNIK TNIK interactions 5.563E-5 1.323E-3 8.451E-3 1.853E-2 4 282
15 int:RYR1 RYR1 interactions 6.062E-5 1.346E-3 8.596E-3 2.019E-2 2 15
16 int:SCGB1D4 SCGB1D4 interactions 2.016E-4 4.195E-3 2.679E-2
6.712E-2
 2 27
17 int:FKBP1B FKBP1B interactions 2.665E-4 5.221E-3 3.335E-2
8.876E-2
 2 31
18 int:LMAN2L LMAN2L interactions 3.404E-4 6.298E-3 4.023E-2
1.134E-1
 2 35
19 int:SRI SRI interactions 4.679E-4 8.201E-3
5.238E-2
1.558E-1
 2 41
20 int:BTNL8 BTNL8 interactions 5.148E-4 8.572E-3
5.475E-2
1.714E-1
 2 43
21 int:EFHC2 EFHC2 interactions 6.152E-4 9.755E-3
6.230E-2
2.049E-1
 2 47
22 int:PRKACA PRKACA interactions 1.291E-3 1.954E-2
1.248E-1
4.300E-1
 3 283
23 int:SCGB1D1 SCGB1D1 interactions 1.518E-3 2.106E-2
1.345E-1
5.056E-1
 2 74
24 int:HHATL HHATL interactions 1.581E-3 2.106E-2
1.345E-1
5.265E-1
 1 2
25 int:ZNF233 ZNF233 interactions 1.581E-3 2.106E-2
1.345E-1
5.265E-1
 1 2
26 int:PON2 PON2 interactions 1.997E-3 2.547E-2
1.626E-1
6.650E-1
 2 85
27 int:DEFA1 DEFA1 interactions 2.138E-3 2.547E-2
1.626E-1
7.121E-1
 2 88
28 int:CALM1 CALM1 interactions 2.258E-3 2.547E-2
1.626E-1
7.519E-1
 3 344
29 int:GOLGA6L5P GOLGA6L5P interactions 2.371E-3 2.547E-2
1.626E-1
7.895E-1
 1 3
30 int:SRRM4 SRRM4 interactions 2.371E-3 2.547E-2
1.626E-1
7.895E-1
 1 3
31 int:MPV17L2 MPV17L2 interactions 2.371E-3 2.547E-2
1.626E-1
7.895E-1
 1 3
32 int:FASLG FASLG interactions 2.486E-3 2.587E-2
1.653E-1
8.280E-1
 2 95
33 int:ATN1 ATN1 interactions 3.027E-3 2.959E-2
1.890E-1
1.000E0
 2 105
34 int:RIMBP2 RIMBP2 interactions 3.160E-3 2.959E-2
1.890E-1
1.000E0
 1 4
35 int:CRIM1 CRIM1 interactions 3.160E-3 2.959E-2
1.890E-1
1.000E0
 1 4
36 int:PPM1A PPM1A interactions 3.199E-3 2.959E-2
1.890E-1
1.000E0
 2 108
37 int:PTPRK PTPRK interactions 3.804E-3 3.286E-2
2.099E-1
1.000E0
 2 118
38 int:KCTD4 KCTD4 interactions 3.948E-3 3.286E-2
2.099E-1
1.000E0
 1 5
39 int:KCNE2 KCNE2 interactions 3.948E-3 3.286E-2
2.099E-1
1.000E0
 1 5
40 int:TAZ TAZ interactions 4.258E-3 3.286E-2
2.099E-1
1.000E0
 2 125
41 int:GNB1 GNB1 interactions 4.459E-3 3.286E-2
2.099E-1
1.000E0
 2 128
42 int:HRC HRC interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
43 int:PCSK6 PCSK6 interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
44 int:KLHL1 KLHL1 interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
45 int:MANBAL MANBAL interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
46 int:AMIGO2 AMIGO2 interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
47 int:CACNA1E CACNA1E interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
48 int:CCDC150 CCDC150 interactions 4.736E-3 3.286E-2
2.099E-1
1.000E0
 1 6
49 int:DOK7 DOK7 interactions 5.524E-3 3.607E-2
2.303E-1
1.000E0
 1 7
50 int:ZFY ZFY interactions 5.524E-3 3.607E-2
2.303E-1
1.000E0
 1 7
Show 45 more annotations

10: Cytoband [Display Chart] 14 input genes in category / 14 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q22-q23 2q22-q23 1.211E-3 1.411E-2 4.589E-2 1.696E-2 1 3
2 15q14-q15 15q14-q15 2.018E-3 1.411E-2 4.589E-2 2.825E-2 1 5
3 17q21-q22 17q21-q22 3.227E-3 1.411E-2 4.589E-2 4.518E-2 1 8
4 7q21-q22 7q21-q22 4.032E-3 1.411E-2 4.589E-2
5.645E-2
 1 10
5 6q22.31 6q22.31 1.125E-2 2.109E-2
6.858E-2
1.575E-1
 1 28
6 19p13 19p13 1.125E-2 2.109E-2
6.858E-2
1.575E-1
 1 28
7 1q32.3 1q32.3 1.165E-2 2.109E-2
6.858E-2
1.631E-1
 1 29
8 12p13.3 12p13.3 1.205E-2 2.109E-2
6.858E-2
1.687E-1
 1 30
9 6p12.3 6p12.3 1.484E-2 2.309E-2
7.508E-2
2.078E-1
 1 37
10 1q43 1q43 2.080E-2 2.913E-2
9.470E-2
2.913E-1
 1 52
11 3p21.3 3p21.3 2.397E-2 3.051E-2
9.919E-2
3.356E-1
 1 60
12 12q13 12q13 2.830E-2 3.302E-2
1.074E-1
3.963E-1
 1 71
13 19q13.3 19q13.3 3.341E-2 3.536E-2
1.150E-1
4.677E-1
 1 84
14 22q13.1 22q13.1 3.536E-2 3.536E-2
1.150E-1
4.951E-1
 1 89
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 12 input genes in category / 137 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 12 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 253 Calcium voltage-gated channel subunits genenames.org 2.592E-21 1.296E-20 2.959E-20 1.296E-20 8 26
2 904 Calcium voltage-gated channel subunits|Membrane associated guanylate kinases genenames.org 5.651E-7 1.413E-6 3.226E-6 2.826E-6 3 26
3 287 Ryanodine receptors|EF-hand domain containing genenames.org 1.196E-6 1.993E-6 4.551E-6 5.980E-6 2 3
4 863 EF-hand domain containing genenames.org 3.493E-4 4.366E-4 9.969E-4 1.746E-3 3 219

13: Coexpression [Display Chart] 14 input genes in category / 981 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 17823248-Table2 Mouse Breast VanHouten07 49genes GeneSigDB 1.136E-13 1.114E-10 8.317E-10 1.114E-10 6 45
2 19252174-Table3 Human Leukemia Hernandez09 66genes GeneSigDB 7.535E-6 3.696E-3 2.759E-2 7.391E-3 3 65
3 19658189-TableS8d Human EmbryonicStemCell Xu09 85genes GeneSigDB 1.575E-5 5.149E-3 3.845E-2 1.545E-2 3 83
4 15923633-Table2 Human BoneMarrow Mori05 20genes GeneSigDB 5.780E-5 1.418E-2
1.058E-1
5.670E-2
 2 19
5 19658189-TableS5 Human EmbryonicStemCell Xu09 622genes GeneSigDB 1.590E-4 3.119E-2
2.329E-1
1.560E-1
 4 483
6 M5709 Genes up-regulated in comparison of ActCD4 versus WTActCD4 (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 2.159E-4 3.530E-2
2.635E-1
2.118E-1
 3 200
Show 1 more annotation

14: Coexpression Atlas [Display Chart] 14 input genes in category / 1007 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory Neuron.excitatory Subtype Excitatory.subGroup1 Top 200 Genes BrainMap 2.216E-8 2.232E-5 1.672E-4 2.232E-5 6 312
2 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a6 Top 200 Genes 5.099E-8 2.568E-5 1.924E-4 5.135E-5 6 359
3 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 GlobusPallidus Top 200 Genes BrainMap 7.506E-7 2.520E-4 1.888E-3 7.559E-4 5 292
4 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Overall Top 200 Genes BrainMap 4.986E-6 6.822E-4 5.111E-3 5.021E-3 4 188
5 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7,Slc17a6 Neuron.excitatory.Slc17a7,Slc17a6 Top 200 BrainMap 4.986E-6 6.822E-4 5.111E-3 5.021E-3 4 188
6 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Cfh BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Cfh BrainMap 5.199E-6 6.822E-4 5.111E-3 5.236E-3 4 190
7 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/Rorb/subGroup2//Gja1 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/Rorb/subGroup2//Gja1 BrainMap 5.309E-6 6.822E-4 5.111E-3 5.346E-3 4 191
8 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gm9946 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Endothelial Stalk/Endothelial Stalk/Endothelial Stalk/Flt1//Gm9946 BrainMap 5.420E-6 6.822E-4 5.111E-3 5.458E-3 4 192
9 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Top 200 BrainMap 1.635E-5 1.646E-3 1.234E-2 1.646E-2 4 254
10 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Subtype Neuron.excitatory.Slc17a6.Rora Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6 Neuron.excitatory.Slc17a6 Subtype Neuron.excitatory.Slc17a6.Rora Top 200 Genes BrainMap 1.635E-5 1.646E-3 1.234E-2 1.646E-2 4 254
11 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.excitatory Top 200 Genes BrainMap 3.181E-5 2.372E-3 1.777E-2 3.203E-2 4 301
12 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7 Top 200 Genes 3.181E-5 2.372E-3 1.777E-2 3.203E-2 4 301
13 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Slc17a7 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype mixed excitatory.Slc17a7 Top 200 Genes 3.264E-5 2.372E-3 1.777E-2 3.287E-2 4 303
14 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.mixed excitatory Top 200 Genes BrainMap 3.660E-5 2.372E-3 1.777E-2 3.685E-2 4 312
15 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Gad1,Gad2 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Gad1,Gad2 Top 200 Genes 3.894E-5 2.372E-3 1.777E-2 3.921E-2 4 317
16 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype excitatory.Slc17a7,Slc17a6 Top 200 Genes 4.139E-5 2.372E-3 1.777E-2 4.168E-2 4 322
17 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Subtype Neuron.mixed excitatory.Gad1,Gad2 Top 200 Genes BrainMap 4.189E-5 2.372E-3 1.777E-2 4.219E-2 4 323
18 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.inhibitory Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Subtype Neuron.inhibitory Top 200 Genes BrainMap 4.240E-5 2.372E-3 1.777E-2 4.270E-2 4 324
19 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 1000 k2 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.943E-5 2.620E-3 1.963E-2 4.977E-2 4 337
20 BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1 PosteriorCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1 PosteriorCortex Top 200 Genes BrainMap 5.791E-5 2.839E-3 2.127E-2
5.831E-2
 4 351
21 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Subtype Excitatory.subGroup2 FrontalCortex Top 200 Genes BrainMap 5.920E-5 2.839E-3 2.127E-2
5.961E-2
 4 353
22 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Slc17a6 Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Subtype inhibitory.Slc17a6 Top 200 Genes 6.253E-5 2.862E-3 2.144E-2
6.296E-2
 4 358
23 BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1 FrontalCortex Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Endothelial Stalk. .Flt1 Endothelial Stalk. .Flt1 Subtype Endothelial Stalk. .Flt1 FrontalCortex Top 200 Genes BrainMap 6.669E-5 2.920E-3 2.188E-2
6.716E-2
 4 364
24 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 500 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 8.543E-5 3.584E-3 2.686E-2
8.603E-2
 4 388
25 gudmap developingLowerUrinaryTract P2 bladder detrusor (LCM) 200 DevelopingLowerUrinaryTract P2 bladder detrusor (LCM) emap-30376 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.426E-4 5.080E-3 3.806E-2
1.436E-1
 3 164
26 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/A/subGroup3//Myoc/Astrocyte.Gja1.Myoc/PosteriorCortex BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Astrocyte/Astrocyte/A/subGroup3//Myoc/Astrocyte.Gja1.Myoc/PosteriorCortex BrainMap 1.558E-4 5.080E-3 3.806E-2
1.569E-1
 3 169
27 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Overall Top 200 Genes BrainMap 1.614E-4 5.080E-3 3.806E-2
1.625E-1
 3 171
28 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup1 Excitatory.subGroup1 Top 200 BrainMap 1.614E-4 5.080E-3 3.806E-2
1.625E-1
 3 171
29 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup4 Inhibitory.subGroup4 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup4 Inhibitory.subGroup4 Overall Top 200 Genes BrainMap 1.757E-4 5.080E-3 3.806E-2
1.769E-1
 3 176
30 BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Slc17a6 Neuron.inhibitory.Slc17a6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.inhibitory.Slc17a6 Neuron.inhibitory.Slc17a6 Overall Top 200 Genes BrainMap 1.786E-4 5.080E-3 3.806E-2
1.799E-1
 3 177
31 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Top 200 BrainMap 1.878E-4 5.080E-3 3.806E-2
1.892E-1
 4 476
32 BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron Neuron Overall Top 200 Genes BrainMap 2.068E-4 5.080E-3 3.806E-2
2.082E-1
 3 186
33 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup9 Inhibitory.subGroup9 Overall Top 200 Genes BrainMap 2.068E-4 5.080E-3 3.806E-2
2.082E-1
 3 186
34 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Overall Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Neuron Overall Top 200 Genes 2.068E-4 5.080E-3 3.806E-2
2.082E-1
 3 186
35 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron BrainMap 2.068E-4 5.080E-3 3.806E-2
2.082E-1
 3 186
36 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup2 Excitatory.subGroup2 Overall Top 200 Genes BrainMap 2.134E-4 5.080E-3 3.806E-2
2.149E-1
 3 188
37 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Overall Top 200 Genes BrainMap 2.134E-4 5.080E-3 3.806E-2
2.149E-1
 3 188
38 BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Inhibitory.subGroup5 Inhibitory.subGroup5 Overall Top 200 Genes BrainMap 2.134E-4 5.080E-3 3.806E-2
2.149E-1
 3 188
39 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup6 Excitatory.subGroup6 Top 200 BrainMap 2.134E-4 5.080E-3 3.806E-2
2.149E-1
 3 188
40 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Overall Top 200 Genes BrainMap 2.167E-4 5.080E-3 3.806E-2
2.183E-1
 3 189
41 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Top 200 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a6,Slc17a7 Neuron.excitatory.Slc17a6,Slc17a7 Top 200 BrainMap 2.167E-4 5.080E-3 3.806E-2
2.183E-1
 3 189
42 BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.excitatory.Slc17a7 Neuron.excitatory.Slc17a7 Overall Top 200 Genes BrainMap 2.201E-4 5.080E-3 3.806E-2
2.217E-1
 3 190
43 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup3 BrainMap 2.236E-4 5.080E-3 3.806E-2
2.251E-1
 3 191
44 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory Neuron.mixed excitatory Overall Top 200 Genes BrainMap 2.236E-4 5.080E-3 3.806E-2
2.251E-1
 3 191
45 BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Neuron.mixed excitatory.Slc17a7 Neuron.mixed excitatory.Slc17a7 Overall Top 200 Genes BrainMap 2.270E-4 5.080E-3 3.806E-2
2.286E-1
 3 192
46 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup3 Excitatory.subGroup3 Top 200 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup3 Excitatory.subGroup3 Top 200 BrainMap 2.412E-4 5.168E-3 3.872E-2
2.429E-1
 3 196
47 BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup3 Excitatory.subGroup3 Overall Top 200 Genes BrainMap BrainAtlas - Mouse McCarroll Excitatory.subGroup3 Excitatory.subGroup3 Overall Top 200 Genes BrainMap 2.412E-4 5.168E-3 3.872E-2
2.429E-1
 3 196
48 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k3 500 DevelopingLowerUrinaryTract e14.5 urethra emap-30902 k-means-cluster#3 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.088E-4 6.478E-3 4.853E-2
3.109E-1
 2 41
49 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Large Intestine/enteroendocrine cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Large Intestine/enteroendocrine cell Tabula Muris Consortium 3.890E-4 7.995E-3
5.990E-2
3.917E-1
 2 46
50 gudmap developingLowerUrinaryTract e14.5 urethra 500 k4 DevelopingLowerUrinaryTract e14.5 urethra emap-30892 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.237E-4 8.532E-3
6.393E-2
4.266E-1
 2 48
Show 45 more annotations

15: Computational [Display Chart] 12 input genes in category / 70 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M426 MORF MLLT10 Neighborhood of MLLT10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.369E-4 1.087E-2
5.255E-2
 2.358E-2 4 304
2 M19749 MORF ERCC4 Neighborhood of ERCC4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.347E-4 1.087E-2
5.255E-2
 3.043E-2 4 325
3 M7214 MORF SUPT3H Neighborhood of SUPT3H MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.660E-4 1.087E-2
5.255E-2
 3.262E-2 4 331
4 M11755 MORF RAD51L3 Neighborhood of RAD51L3 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 8.751E-4 1.217E-2
5.883E-2
6.126E-2
 4 391
5 M19725 MORF DMPK Neighborhood of DMPK MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.038E-3 1.217E-2
5.883E-2
7.265E-2
 3 176
6 M13322 MORF PRKCA Neighborhood of PRKCA MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.162E-3 1.217E-2
5.883E-2
8.133E-2
 3 183
7 M3103 MORF MAGEA9 Neighborhood of MAGEA9 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.217E-3 1.217E-2
5.883E-2
8.522E-2
 4 427
8 M6409 MORF IFNA1 Neighborhood of IFNA1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.658E-3 1.450E-2
7.010E-2
1.160E-1
 3 207
9 M785 MODULE 316 Ion channels. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.025E-3 2.274E-2
1.099E-1
2.117E-1
 2 70
10 M8350 MORF MAGEA8 Neighborhood of MAGEA8 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.248E-3 2.274E-2
1.099E-1
2.274E-1
 3 262
11 M230 MORF FSHR Neighborhood of FSHR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.959E-3 2.333E-2
1.127E-1
2.771E-1
 3 281
12 M5734 MORF MDM2 Neighborhood of MDM2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.999E-3 2.333E-2
1.127E-1
2.799E-1
 3 282
13 M2749 MORF CAMK4 Neighborhood of CAMK4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 4.454E-3 2.398E-2
1.159E-1
3.118E-1
 3 293
14 M15658 MORF ATF2 Neighborhood of ATF2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 6.317E-3 3.159E-2
1.527E-1
4.422E-1
 3 332
Show 9 more annotations

16: MicroRNA [Display Chart] 14 input genes in category / 573 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GTGCCAA,MIR-96:MSigDB GTGCCAA,MIR-96:MSigDB MSigDB 2.238E-7 1.090E-4 7.555E-4 1.282E-4 4 283
2 hsa-miR-1271:PITA hsa-miR-1271:PITA TOP PITA 5.583E-7 1.090E-4 7.555E-4 3.199E-4 4 356
3 hsa-miR-96:PITA hsa-miR-96:PITA TOP PITA 5.708E-7 1.090E-4 7.555E-4 3.271E-4 4 358
4 hsa-miR-377:PITA hsa-miR-377:PITA TOP PITA 1.531E-6 2.193E-4 1.520E-3 8.773E-4 4 459
5 hsa-miR-129-5p:PITA hsa-miR-129-5p:PITA TOP PITA 1.936E-6 2.218E-4 1.537E-3 1.109E-3 4 487
6 hsa-miR-1207-5p:PITA hsa-miR-1207-5p:PITA TOP PITA 4.653E-6 4.444E-4 3.079E-3 2.666E-3 3 171
7 hsa-miR-1193:TargetScan hsa-miR-1193 TargetScan 1.190E-5 9.737E-4 6.747E-3 6.816E-3 3 234
8 hsa-miR-1300:PITA hsa-miR-1300:PITA TOP PITA 1.989E-5 1.424E-3 9.869E-3 1.139E-2 3 278
9 hsa-miR-155-5p:TargetScan hsa-miR-155-5p TargetScan 5.315E-5 3.384E-3 2.344E-2 3.045E-2 3 387
10 hsa-miR-544:PITA hsa-miR-544:PITA TOP PITA 7.876E-5 4.230E-3 2.931E-2 4.513E-2 3 442
11 hsa-miR-7106-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.121E-5 4.230E-3 2.931E-2 4.653E-2 2 69
12 hsa-miR-377-3p:TargetScan hsa-miR-377-3p TargetScan 9.622E-5 4.594E-3 3.183E-2
5.513E-2
 3 473
13 hsa-miR-187-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.205E-4 5.310E-3 3.679E-2
6.903E-2
 2 84
14 hsa-miR-6780b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.383E-4 5.521E-3 3.826E-2
7.926E-2
 2 90
15 hsa-miR-4780:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.445E-4 5.521E-3 3.826E-2
8.282E-2
 2 92
16 hsa-miR-504:PITA hsa-miR-504:PITA TOP PITA 1.847E-4 6.614E-3 4.583E-2
1.058E-1
 2 104
17 hsa-miR-220a:mirSVR highEffct hsa-miR-220a:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.377E-4 8.011E-3
5.551E-2
1.362E-1
 2 118
18 hsa-miR-1275:PITA hsa-miR-1275:PITA TOP PITA 3.017E-4 9.605E-3
6.655E-2
1.729E-1
 2 133
19 hsa-miR-637:PITA hsa-miR-637:PITA TOP PITA 3.201E-4 9.653E-3
6.688E-2
1.834E-1
 2 137
20 hsa-miR-581:PITA hsa-miR-581:PITA TOP PITA 3.834E-4 1.006E-2
6.974E-2
2.197E-1
 2 150
21 hsa-miR-1302:PITA hsa-miR-1302:PITA TOP PITA 3.885E-4 1.006E-2
6.974E-2
2.226E-1
 2 151
22 hsa-miR-1225-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.936E-4 1.006E-2
6.974E-2
2.255E-1
 2 152
23 hsa-miR-147:PITA hsa-miR-147:PITA TOP PITA 4.040E-4 1.006E-2
6.974E-2
2.315E-1
 2 154
24 hsa-miR-149:PITA hsa-miR-149:PITA TOP PITA 4.917E-4 1.174E-2
8.135E-2
2.818E-1
 2 170
25 hsa-miR-208a:mirSVR highEffct hsa-miR-208a:mirSVR conserved highEffect-0.5 MicroRNA.org 5.448E-4 1.249E-2
8.652E-2
3.122E-1
 2 179
26 hsa-miR-455-5p:TargetScan hsa-miR-455-5p TargetScan 5.879E-4 1.296E-2
8.978E-2
3.369E-1
 2 186
27 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 6.925E-4 1.463E-2
1.013E-1
3.968E-1
 2 202
28 hsa-miR-4270:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.981E-4 1.463E-2
1.013E-1
4.573E-1
 2 217
29 hsa-miR-6754-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.054E-4 1.463E-2
1.013E-1
4.615E-1
 2 218
30 hsa-miR-4441:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.127E-4 1.463E-2
1.013E-1
4.657E-1
 2 219
31 hsa-miR-143:PITA hsa-miR-143:PITA TOP PITA 8.201E-4 1.463E-2
1.013E-1
4.699E-1
 2 220
32 hsa-miR-892b:PITA hsa-miR-892b:PITA TOP PITA 8.349E-4 1.463E-2
1.013E-1
4.784E-1
 2 222
33 hsa-miR-532-5p:PITA hsa-miR-532-5p:PITA TOP PITA 8.424E-4 1.463E-2
1.013E-1
4.827E-1
 2 223
34 hsa-miR-4524b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.266E-4 1.498E-2
1.038E-1
5.309E-1
 2 234
35 hsa-miR-623:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.822E-4 1.498E-2
1.038E-1
5.628E-1
 2 241
36 hsa-miR-452-5p:TargetScan hsa-miR-452-5p TargetScan 9.984E-4 1.498E-2
1.038E-1
5.721E-1
 2 243
37 hsa-miR-892c-3p:TargetScan hsa-miR-892c-3p TargetScan 9.984E-4 1.498E-2
1.038E-1
5.721E-1
 2 243
38 hsa-miR-127-5p:PITA hsa-miR-127-5p:PITA TOP PITA 1.039E-3 1.498E-2
1.038E-1
5.956E-1
 2 248
39 hsa-miR-455-3p.2:TargetScan hsa-miR-455-3p.2 TargetScan 1.039E-3 1.498E-2
1.038E-1
5.956E-1
 2 248
40 hsa-miR-136:PITA hsa-miR-136:PITA TOP PITA 1.115E-3 1.498E-2
1.038E-1
6.391E-1
 2 257
41 hsa-miR-582-3p:PITA hsa-miR-582-3p:PITA TOP PITA 1.124E-3 1.498E-2
1.038E-1
6.440E-1
 2 258
42 hsa-miR-513a-5p:PITA hsa-miR-513a-5p:PITA TOP PITA 1.141E-3 1.498E-2
1.038E-1
6.539E-1
 2 260
43 hsa-miR-136-5p:TargetScan hsa-miR-136-5p TargetScan 1.159E-3 1.498E-2
1.038E-1
6.639E-1
 2 262
44 CACTGCC,MIR-34A:MSigDB CACTGCC,MIR-34A:MSigDB MSigDB 1.203E-3 1.498E-2
1.038E-1
6.891E-1
 2 267
45 CACTGCC,MIR-34C:MSigDB CACTGCC,MIR-34C:MSigDB MSigDB 1.203E-3 1.498E-2
1.038E-1
6.891E-1
 2 267
46 CACTGCC,MIR-449:MSigDB CACTGCC,MIR-449:MSigDB MSigDB 1.203E-3 1.498E-2
1.038E-1
6.891E-1
 2 267
47 hsa-miR-1207-3p:PITA hsa-miR-1207-3p:PITA TOP PITA 1.284E-3 1.565E-2
1.085E-1
7.357E-1
 2 276
48 hsa-miR-605:PITA hsa-miR-605:PITA TOP PITA 1.416E-3 1.690E-2
1.171E-1
8.111E-1
 2 290
49 hsa-miR-335-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.563E-3 1.828E-2
1.267E-1
8.959E-1
 2 305
50 hsa-miR-139-5p:TargetScan hsa-miR-139-5p TargetScan 1.666E-3 1.882E-2
1.304E-1
9.546E-1
 2 315
Show 45 more annotations

17: Drug [Display Chart] 14 input genes in category / 5085 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000162753 IHC-64 Stitch 8.684E-27 2.208E-23 2.012E-22 4.416E-23 10 33
2 CID000190902 CNS 1145 Stitch 8.684E-27 2.208E-23 2.012E-22 4.416E-23 10 33
3 CID000002752 Cinildipine Stitch 3.329E-24 5.642E-21 5.141E-20 1.693E-20 10 56
4 CID000004494 nilvadipine Stitch 7.043E-24 7.138E-21 6.504E-20 3.582E-20 10 60
5 CID000104822 dihydropyridine Stitch 8.404E-24 7.138E-21 6.504E-20 4.273E-20 12 193
6 CID000003667 IAA-94 Stitch 8.423E-24 7.138E-21 6.504E-20 4.283E-20 10 61
7 CID000065866 lercanidipine Stitch 1.193E-23 8.669E-21 7.899E-20 6.068E-20 10 63
8 CID000001234 gallopamil Stitch 2.314E-23 1.471E-20 1.340E-19 1.177E-19 10 67
9 CID000068733 AC1L2AC7 Stitch 3.172E-23 1.792E-20 1.633E-19 1.613E-19 10 69
10 CID000002761 CAS 298-57-7 Stitch 5.792E-23 2.945E-20 2.684E-19 2.945E-19 10 73
11 CID000003291 ethosuximide Stitch 6.696E-23 3.096E-20 2.820E-19 3.405E-19 10 74
12 CID000004499 nisoldipine Stitch 1.172E-22 4.967E-20 4.526E-19 5.960E-19 10 78
13 CID005287890 N-cyclopentyl-N-cyclobutylformamide Stitch 1.342E-22 5.249E-20 4.782E-19 6.823E-19 10 79
14 CID000004497 nimodipine Stitch 1.642E-22 5.965E-20 5.435E-19 8.351E-19 11 145
15 CID000002303 Bay K 8644 Stitch 2.415E-22 8.187E-20 7.459E-19 1.228E-18 11 150
16 CID000004008 manidipine Stitch 9.387E-22 2.983E-19 2.718E-18 4.773E-18 10 95
17 CID000005422 isotetrandrine Stitch 1.168E-21 3.494E-19 3.183E-18 5.939E-18 10 97
18 CID000004507 nitrendipine Stitch 1.300E-21 3.674E-19 3.347E-18 6.613E-18 10 98
19 CID000003784 isradipine Stitch 1.607E-21 4.300E-19 3.918E-18 8.171E-18 10 100
20 CID000005657 NSC7524 Stitch 2.159E-21 5.489E-19 5.001E-18 1.098E-17 11 182
21 CID000003954 loperamide Stitch 2.676E-21 6.479E-19 5.903E-18 1.361E-17 10 105
22 CID000003878 lamotrigine Stitch 7.553E-21 1.746E-18 1.591E-17 3.841E-17 10 116
23 CID004473765 AC1NBU2S Stitch 8.257E-21 1.826E-18 1.663E-17 4.199E-17 10 117
24 CID000002351 bepridil Stitch 1.781E-20 3.773E-18 3.438E-17 9.056E-17 10 126
25 CID000016362 pimozide Stitch 1.933E-20 3.931E-18 3.582E-17 9.828E-17 10 127
26 CID000023926 lanthanum Stitch 3.923E-20 7.673E-18 6.991E-17 1.995E-16 10 136
27 CID000002951 Dantrolene-13C3 Stitch 7.597E-20 1.380E-17 1.257E-16 3.863E-16 10 145
28 CID000004473 nicardipine Stitch 7.597E-20 1.380E-17 1.257E-16 3.863E-16 10 145
29 CID000004914 procaine Stitch 1.320E-19 2.315E-17 2.109E-16 6.714E-16 10 153
30 CID000003446 gabapentin Stitch 3.665E-19 6.012E-17 5.478E-16 1.864E-15 10 169
31 CID000003333 felodipine Stitch 3.665E-19 6.012E-17 5.478E-16 1.864E-15 10 169
32 CID000003894 lavendustin A Stitch 4.135E-19 6.571E-17 5.987E-16 2.103E-15 10 171
33 CID000005070 riluzole Stitch 4.941E-19 7.614E-17 6.937E-16 2.513E-15 10 174
34 CID000004680 papaverine Stitch 5.555E-19 8.220E-17 7.490E-16 2.824E-15 10 176
35 CID000002548 AC1L1DXE Stitch 5.658E-19 8.220E-17 7.490E-16 2.877E-15 11 299
36 CID000003075 NSC759576 Stitch 1.282E-18 1.762E-16 1.605E-15 6.518E-15 10 191
37 CID000002284 baclofen Stitch 1.282E-18 1.762E-16 1.605E-15 6.518E-15 10 191
38 CID000023982 gadolinium Stitch 1.949E-18 2.608E-16 2.376E-15 9.909E-15 10 199
39 CID000001775 phenytoin Stitch 5.170E-18 6.741E-16 6.142E-15 2.629E-14 10 219
40 CID000060662 mibefradil Stitch 7.149E-18 9.088E-16 8.280E-15 3.635E-14 8 64
41 CID000003121 valproate Stitch 8.388E-18 1.040E-15 9.479E-15 4.265E-14 11 381
42 CID000061492 cobalt-60 Stitch 1.087E-17 1.316E-15 1.199E-14 5.527E-14 11 390
43 CID000004485 nifedipine Stitch 2.165E-17 2.560E-15 2.333E-14 1.101E-13 11 415
44 CID000004946 propranolol Stitch 3.555E-17 4.109E-15 3.744E-14 1.808E-13 11 434
45 CID000005618 U46619 Stitch 7.484E-17 8.457E-15 7.705E-14 3.805E-13 10 285
46 CID000000119 gamma-aminobutyric acid Stitch 9.433E-17 1.043E-14 9.500E-14 4.796E-13 11 474
47 CID000073211 AC1NUZ8M Stitch 1.494E-16 1.616E-14 1.472E-13 7.595E-13 8 92
48 CID000001915 8-bromoguanosine 3',5'-cyclic monophosphate Stitch 1.640E-16 1.737E-14 1.583E-13 8.338E-13 10 308
49 CID000003562 halothane Stitch 1.993E-16 2.068E-14 1.884E-13 1.013E-12 10 314
50 CID000005631 AC1L1KS5 Stitch 3.715E-16 3.778E-14 3.443E-13 1.889E-12 10 334
Show 45 more annotations

18: Disease [Display Chart] 14 input genes in category / 342 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0011071 Sudden death DisGeNET Curated 3.466E-7 1.185E-4 7.602E-4 1.185E-4 3 17
2 cv:C1631597 Catecholaminergic polymorphic ventricular tachycardia Clinical Variations 2.078E-6 2.368E-4 1.519E-3 7.108E-4 2 3
3 OMIN:604772 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1; CPVT1 OMIM 2.078E-6 2.368E-4 1.519E-3 7.108E-4 2 3
4 C0039070 Syncope DisGeNET Curated 3.604E-6 2.368E-4 1.519E-3 1.233E-3 3 36
5 C0395920 Migrainous vertigo DisGeNET BeFree 4.155E-6 2.368E-4 1.519E-3 1.421E-3 2 4
6 OMIN:254770 EPILEPSY, MYOCLONIC JUVENILE; EJM OMIM 4.155E-6 2.368E-4 1.519E-3 1.421E-3 2 4
7 C0012833 Dizziness DisGeNET Curated 7.130E-6 2.897E-4 1.858E-3 2.438E-3 3 45
8 C0042571 Vertigo DisGeNET Curated 7.623E-6 2.897E-4 1.858E-3 2.607E-3 3 46
9 C0024591 Malignant hyperpyrexia due to anesthesia DisGeNET Curated 7.623E-6 2.897E-4 1.858E-3 2.607E-3 3 46
10 C2348199 Short Qt Syndrome DisGeNET BeFree 1.038E-5 3.549E-4 2.276E-3 3.549E-3 2 6
11 C0014553 Absence Epilepsy DisGeNET Curated 1.461E-5 4.543E-4 2.914E-3 4.997E-3 3 57
12 C0085612 Ventricular arrhythmia DisGeNET Curated 2.073E-5 5.909E-4 3.790E-3 7.090E-3 3 64
13 C0023976 Long QT Syndrome DisGeNET Curated 2.489E-5 6.547E-4 4.199E-3 8.511E-3 3 68
14 C0027125 Myotonia DisGeNET Curated 3.107E-5 7.589E-4 4.867E-3 1.062E-2 2 10
15 C0271390 Nystagmus, End-Position DisGeNET Curated 6.270E-5 1.430E-3 9.168E-3 2.144E-2 2 14
16 C0338484 Familial Hemiplegic Migraine DisGeNET BeFree 9.357E-5 2.000E-3 1.283E-2 3.200E-2 2 17
17 C0030552 Paresis DisGeNET Curated 1.078E-4 2.168E-3 1.390E-2 3.685E-2 3 111
18 C1720189 Episodic Ataxia DisGeNET Curated 1.735E-4 3.124E-3 2.003E-2
5.935E-2
 2 23
19 C1631597 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder) DisGeNET Curated 1.735E-4 3.124E-3 2.003E-2
5.935E-2
 2 23
20 C0694539 Chronic atrial fibrillation DisGeNET BeFree 1.892E-4 3.236E-3 2.075E-2
6.472E-2
 2 24
21 C0751122 Infantile Severe Myoclonic Epilepsy DisGeNET Curated 2.056E-4 3.348E-3 2.147E-2
7.031E-2
 2 25
22 C1270972 Mild cognitive disorder DisGeNET BeFree 2.730E-4 4.244E-3 2.722E-2
9.336E-2
 3 152
23 C0270853 Myoclonic Epilepsy, Juvenile DisGeNET Curated 3.177E-4 4.546E-3 2.915E-2
1.087E-1
 2 31
24 C0041671 Attention Deficit Disorder DisGeNET BeFree 4.787E-4 4.546E-3 2.915E-2
1.637E-1
 2 38
25 C0014548 Epilepsy, Generalized DisGeNET Curated 4.787E-4 4.546E-3 2.915E-2
1.637E-1
 2 38
26 C0042514 Tachycardia, Ventricular DisGeNET Curated 5.575E-4 4.546E-3 2.915E-2
1.907E-1
 2 41
27 C0018790 Cardiac Arrest DisGeNET Curated 6.009E-4 4.546E-3 2.915E-2
2.055E-1
 3 199
28 C0004134 Ataxia DisGeNET Curated 6.187E-4 4.546E-3 2.915E-2
2.116E-1
 3 201
29 C1142166 Brugada Syndrome (disorder) DisGeNET Curated 7.328E-4 4.546E-3 2.915E-2
2.506E-1
 2 47
30 C0741923 cardiac event DisGeNET BeFree 7.964E-4 4.546E-3 2.915E-2
2.724E-1
 2 49
31 C0338480 Common Migraine DisGeNET Curated 8.292E-4 4.546E-3 2.915E-2
2.836E-1
 2 50
32 OMIN:183086 SPINOCEREBELLAR ATAXIA 6; SCA6 OMIM 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
33 cv:C1832916 Timothy syndrome Clinical Variations 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
34 C4021571 Abnormal vestibulo-ocular reflex DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
35 C0231690 Titubation DisGeNET BeFree 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
36 C4025298 Effort-induced polymorphic ventricular tachycardias DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
37 C0585544 Downbeat nystagmus DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
38 C0751535 Syncope, Cardiogenic DisGeNET BeFree 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
39 C4018858 J wave DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
40 OMIN:600996 ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 2; ARVD2 OMIM 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
41 cv:C1832894 Familial hemiplegic migraine type 1 Clinical Variations 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
42 cv:C3280284 Mental retardation, autosomal dominant 10 Clinical Variations 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
43 C2678478 Brugada Syndrome 3 DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
44 cv:C1850778 Juvenile myoclonic epilepsy Clinical Variations 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
45 cv:C1832931 Arrhythmogenic right ventricular cardiomyopathy, type 2 Clinical Variations 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
46 cv:CN180177 Ventricular tachycardia, catecholaminergic polymorphic, 5, with or without muscle weakness Clinical Variations 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
47 OMIN:601005 TIMOTHY SYNDROME; TS OMIM 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
48 C3809536 VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 5, WITH OR WITHOUT MUSCLE WEAKNESS DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
49 C0235242 Syncope, Effort DisGeNET BeFree 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
50 C1866039 EPISODIC ATAXIA, TYPE 5 DisGeNET Curated 8.639E-4 4.546E-3 2.915E-2
2.955E-1
 1 1
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