Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc173_16, positive side

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1: GO: Molecular Function [Display Chart] 16 input genes in category / 75 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004713 protein tyrosine kinase activity 4.654E-4 3.214E-2
1.575E-1
 3.490E-2 3 182
2 GO:0051435 BH4 domain binding 8.574E-4 3.214E-2
1.575E-1
6.431E-2
 1 1
3 GO:0004962 endothelin receptor activity 1.714E-3 3.214E-2
1.575E-1
1.286E-1
 1 2
4 GO:0008120 ceramide glucosyltransferase activity 1.714E-3 3.214E-2
1.575E-1
1.286E-1
 1 2
5 GO:0005006 epidermal growth factor-activated receptor activity 2.570E-3 3.855E-2
1.890E-1
1.928E-1
 1 3

2: GO: Biological Process [Display Chart] 16 input genes in category / 675 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007229 integrin-mediated signaling pathway 1.103E-6 7.448E-4 5.283E-3 7.448E-4 4 95
2 GO:0007172 signal complex assembly 1.932E-5 6.520E-3 4.625E-2 1.304E-2 2 8
3 GO:0007173 epidermal growth factor receptor signaling pathway 1.822E-4 2.771E-2
1.965E-1
1.230E-1
 3 132
4 GO:0060396 growth hormone receptor signaling pathway 1.889E-4 2.771E-2
1.965E-1
1.275E-1
 2 24
5 GO:0071378 cellular response to growth hormone stimulus 2.052E-4 2.771E-2
1.965E-1
1.385E-1
 2 25
6 GO:0038127 ERBB signaling pathway 2.708E-4 3.047E-2
2.161E-1
1.828E-1
 3 151
7 GO:0060416 response to growth hormone 4.529E-4 4.078E-2
2.892E-1
3.057E-1
 2 37
8 GO:0007179 transforming growth factor beta receptor signaling pathway 4.833E-4 4.078E-2
2.892E-1
3.263E-1
 3 184
Show 3 more annotations

3: GO: Cellular Component [Display Chart] 16 input genes in category / 65 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001725 stress fiber 2.250E-5 5.554E-4 2.643E-3 1.462E-3 3 67
2 GO:0097517 contractile actin filament bundle 2.250E-5 5.554E-4 2.643E-3 1.462E-3 3 67
3 GO:0032432 actin filament bundle 2.912E-5 5.554E-4 2.643E-3 1.893E-3 3 73
4 GO:0042641 actomyosin 3.418E-5 5.554E-4 2.643E-3 2.222E-3 3 77
5 GO:0005925 focal adhesion 2.661E-4 2.719E-3 1.294E-2 1.730E-2 4 393
6 GO:0005924 cell-substrate adherens junction 2.793E-4 2.719E-3 1.294E-2 1.815E-2 4 398
7 GO:0030055 cell-substrate junction 2.929E-4 2.719E-3 1.294E-2 1.904E-2 4 403
8 GO:0015629 actin cytoskeleton 5.505E-4 4.233E-3 2.015E-2 3.578E-2 4 476
9 GO:0005912 adherens junction 5.862E-4 4.233E-3 2.015E-2 3.810E-2 4 484
10 GO:0008537 proteasome activator complex 2.516E-3 1.636E-2
7.784E-2
1.636E-1
 1 3
11 GO:0016604 nuclear body 3.215E-3 1.817E-2
8.646E-2
2.090E-1
 3 364
12 GO:0035363 histone locus body 3.354E-3 1.817E-2
8.646E-2
2.180E-1
 1 4
13 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex 5.027E-3 2.513E-2
1.196E-1
3.267E-1
 1 6
14 GO:0070776 MOZ/MORF histone acetyltransferase complex 5.862E-3 2.540E-2
1.209E-1
3.810E-1
 1 7
15 GO:0070775 H3 histone acetyltransferase complex 5.862E-3 2.540E-2
1.209E-1
3.810E-1
 1 7
16 GO:0019897 extrinsic component of plasma membrane 7.045E-3 2.694E-2
1.282E-1
4.579E-1
 2 152
17 GO:0042383 sarcolemma 7.045E-3 2.694E-2
1.282E-1
4.579E-1
 2 152
18 GO:0030027 lamellipodium 1.039E-2 3.751E-2
1.785E-1
6.752E-1
 2 186
Show 13 more annotations

4: Human Phenotype [Display Chart] 5 input genes in category / 240 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 15 input genes in category / 690 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0030072 round face 2.928E-5 2.020E-2
1.437E-1
 2.020E-2 2 6

6: Domain [Display Chart] 16 input genes in category / 129 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR032973 EFEMP1 InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
2 IPR029556 TP53INP1 InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
3 IPR031184 ELL InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
4 IPR028638 ING5 InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
5 IPR026720 MAATS1 InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
6 IPR012725 Chaperone DnaK InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
7 IPR030738 ARHGEF25 InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
8 IPR032840 MAATS1 dom InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
9 IPR026200 Tyrobp InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
10 IPR002175 ETA rcpt InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
11 IPR027006 SYTL2 InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
12 IPR025993 Ceramide glucosylTrfase InterPro 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
13 PF14738 PaaSYMP Pfam 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
14 PF13506 Glyco transf 21 Pfam 8.540E-4 7.105E-3 3.866E-2
1.102E-1
 1 1
15 PF00412 LIM Pfam 1.552E-3 7.105E-3 3.866E-2
2.001E-1
 2 69
16 2.10.110.10 - Gene3D 1.596E-3 7.105E-3 3.866E-2
2.059E-1
 2 70
17 IPR001781 Znf LIM InterPro 1.642E-3 7.105E-3 3.866E-2
2.118E-1
 2 71
18 SM00132 LIM SMART 1.642E-3 7.105E-3 3.866E-2
2.118E-1
 2 71
19 PS50023 LIM DOMAIN 2 PROSITE 1.642E-3 7.105E-3 3.866E-2
2.118E-1
 2 71
20 PS00478 LIM DOMAIN 1 PROSITE 1.642E-3 7.105E-3 3.866E-2
2.118E-1
 2 71
21 PS50886 TRBD PROSITE 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
22 IPR002547 tRNA-bd dom InterPro 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
23 IPR001904 Paxillin InterPro 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
24 PF01588 tRNA bind Pfam 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
25 PF14839 DOR Pfam 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
26 IPR001985 S-AdoMet decarboxylase InterPro 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
27 PF03623 Focal AT Pfam 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
28 PD006413 Focal adhesion target reg ProDom 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
29 IPR029431 TP53INP InterPro 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
30 IPR005189 Focal adhesion kin target dom InterPro 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
31 IPR000499 Endthln rcpt InterPro 1.707E-3 7.105E-3 3.866E-2
2.202E-1
 1 2
32 PF02251 PA28 alpha Pfam 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
33 IPR003186 Proteasome activ pa28 C InterPro 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
34 PF02252 PA28 beta Pfam 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
35 1.20.120.180 - Gene3D 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
36 PF10390 ELL Pfam 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
37 IPR003185 Proteasome activ pa28 N InterPro 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
38 IPR019464 ELL N InterPro 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
39 1.20.5.120 - Gene3D 2.560E-3 8.468E-3 4.607E-2
3.302E-1
 1 3
40 IPR009077 Proteasome activ pa28 InterPro 3.412E-3 1.100E-2
5.987E-2
4.401E-1
 1 4
41 IPR028651 ING fam InterPro 4.263E-3 1.250E-2
6.801E-2
5.500E-1
 1 5
42 IPR024610 ING N histone binding InterPro 4.263E-3 1.250E-2
6.801E-2
5.500E-1
 1 5
43 SM01408 ING SMART 4.263E-3 1.250E-2
6.801E-2
5.500E-1
 1 5
44 PF12998 ING Pfam 4.263E-3 1.250E-2
6.801E-2
5.500E-1
 1 5
45 PF07303 Occludin ELL Pfam 5.114E-3 1.404E-2
7.637E-2
6.597E-1
 1 6
46 IPR031176 ELL/occludin InterPro 5.114E-3 1.404E-2
7.637E-2
6.597E-1
 1 6
47 IPR010844 Occludin ELL InterPro 5.114E-3 1.404E-2
7.637E-2
6.597E-1
 1 6
48 IPR011011 Znf FYVE PHD InterPro 6.827E-3 1.835E-2
9.983E-2
8.807E-1
 2 147
49 PF02318 FYVE 2 Pfam 9.357E-3 2.463E-2
1.340E-1
1.000E0
 1 11
50 IPR029047 HSP70 peptide-bd InterPro 1.020E-2 2.483E-2
1.351E-1
1.000E0
 1 12
Show 45 more annotations

7: Pathway [Display Chart] 14 input genes in category / 342 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M3342 Integrin Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 9.330E-6 3.191E-3 2.047E-2 3.191E-3 3 38
2 1270241 Signal regulatory protein (SIRP) family interactions BioSystems: REACTOME 9.095E-5 1.209E-2
7.753E-2
 3.110E-2 2 13
3 M12851 Cell to Cell Adhesion Signaling MSigDB C2 BIOCARTA (v6.0) 1.060E-4 1.209E-2
7.753E-2
 3.626E-2 2 14
4 M13143 uCalpain and friends in Cell spread MSigDB C2 BIOCARTA (v6.0) 1.778E-4 1.484E-2
9.517E-2
6.082E-2
 2 18
5 M3873 Apoptotic Signaling in Response to DNA Damage MSigDB C2 BIOCARTA (v6.0) 2.678E-4 1.484E-2
9.517E-2
9.158E-2
 2 22
6 M882 CXCR4 Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 3.195E-4 1.484E-2
9.517E-2
1.093E-1
 2 24
7 M6355 Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia MSigDB C2 BIOCARTA (v6.0) 3.195E-4 1.484E-2
9.517E-2
1.093E-1
 2 24
8 M8719 mCalpain and friends in Cell motility MSigDB C2 BIOCARTA (v6.0) 3.471E-4 1.484E-2
9.517E-2
1.187E-1
 2 25
9 1270231 Cell-Cell communication BioSystems: REACTOME 4.069E-4 1.546E-2
9.916E-2
1.392E-1
 3 134
10 M12975 VEGF, Hypoxia, and Angiogenesis MSigDB C2 BIOCARTA (v6.0) 4.686E-4 1.602E-2
1.028E-1
1.602E-1
 2 29
11 M6220 Agrin in Postsynaptic Differentiation MSigDB C2 BIOCARTA (v6.0) 7.238E-4 2.122E-2
1.361E-1
2.475E-1
 2 36
12 M19358 Signaling of Hepatocyte Growth Factor Receptor MSigDB C2 BIOCARTA (v6.0) 7.647E-4 2.122E-2
1.361E-1
2.615E-1
 2 37
13 PW:0000286 integrin signaling Pathway Ontology 8.066E-4 2.122E-2
1.361E-1
2.759E-1
 2 38
14 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 1.222E-3 2.931E-2
1.880E-1
4.178E-1
 4 446
15 83067 Focal adhesion BioSystems: KEGG 1.286E-3 2.931E-2
1.880E-1
4.397E-1
 3 199
16 P00056 VEGF signaling pathway PantherDB 1.872E-3 3.897E-2
2.499E-1
6.404E-1
 2 58
17 83066 VEGF signaling pathway BioSystems: KEGG 1.937E-3 3.897E-2
2.499E-1
6.624E-1
 2 59
18 413367 Lactosylceramide biosynthesis BioSystems: KEGG 2.248E-3 4.222E-2
2.708E-1
7.688E-1
 1 2
19 137928 LPA receptor mediated events BioSystems: Pathway Interaction Database 2.346E-3 4.222E-2
2.708E-1
8.022E-1
 2 65
Show 14 more annotations

8: Pubmed [Display Chart] 16 input genes in category / 3089 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 24036928 Integrin-β5 and zyxin mediate formation of ventral stress fibers in response to transforming growth factor β. Pubmed 2.109E-9 6.514E-6 5.611E-5 6.514E-6 3 7
2 21741599 Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
3 15175910 Differential regulation of focal adhesion kinase and paxillin phosphorylation by the small GTP-binding protein Rho in human corneal epithelial cells. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
4 29040002 FAK-Src-paxillin system expression and disease outcome in human neuroblastoma. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
5 26980710 FAK and paxillin, two potential targets in pancreatic cancer. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
6 23990882 LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
7 22095445 Endothelial paxillin and focal adhesion kinase (FAK) play a critical role in neutrophil transmigration. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
8 24671495 Paxillin and focal adhesion kinase colocalise in human skeletal muscle and its associated microvasculature. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
9 9230116 Adhesion of fibroblasts to fibronectin stimulates both serine and tyrosine phosphorylation of paxillin. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
10 24642576 Altering FAK-paxillin interactions reduces adhesion, migration and invasion processes. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
11 27068537 Nuclear transport of paxillin depends on focal adhesion dynamics and FAT domains. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
12 22075845 Expression of paxillin and FAK mRNA and the related clinical significance in esophageal carcinoma. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
13 9658172 Serine and threonine phosphorylation of the paxillin LIM domains regulates paxillin focal adhesion localization and cell adhesion to fibronectin. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
14 12548551 Dissociation of focal adhesion kinase and paxillin tyrosine phosphorylation induced by bombesin and lysophosphatidic acid from epidermal growth factor receptor transactivation in Swiss 3T3 cells. Pubmed 1.645E-7 2.674E-5 2.303E-4 5.082E-4 2 2
15 19126677 FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
16 15155793 Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
17 11779709 Tyrosine phosphorylation of paxillin, FAK, and p130CAS: effects on cell spreading and migration. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
18 8986614 Focal adhesion and stress fiber formation is regulated by tyrosine phosphatase activity. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
19 22989773 C(16)-Ceramide-induced F-actin regulation stimulates mouse embryonic stem cell migration: involvement of N-WASP/Cdc42/Arp2/3 complex and cofilin-1/α-actinin. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
20 19492042 Nudel and FAK as antagonizing strength modulators of nascent adhesions through paxillin. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
21 28314297 Expression and Clinical Significance of Concomitant FAK/SRC and p-Paxillin in Mobile Tongue Squamous Cell Carcinoma. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
22 19917054 LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillin. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
23 15494312 Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
24 22094095 [Mechanisms of focal adhesion kinase in the proliferation of human pulmonary artery smooth cells under hypoxia]. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
25 27095481 Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
26 21486952 Actomyosin-generated tension controls the molecular kinetics of focal adhesions. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
27 27130522 Retinoic acid induces nuclear FAK translocation and reduces breast cancer cell adhesion through Moesin, FAK, and Paxillin. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
28 18449907 Genetic upregulation of matriptase-2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
29 10938112 Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
30 7529872 Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
31 15138291 Vinculin modulation of paxillin-FAK interactions regulates ERK to control survival and motility. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
32 7561682 Direct association of pp125FAK with paxillin, the focal adhesion-targeting mechanism of pp125FAK. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
33 9756887 Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
34 26956728 Bit1 knockdown contributes to growth suppression as well as the decreases of migration and invasion abilities in esophageal squamous cell carcinoma via suppressing FAK-paxillin pathway. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
35 19628583 A preformed signaling complex mediates GnRH-activated ERK phosphorylation of paxillin and FAK at focal adhesions in L beta T2 gonadotrope cells. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
36 9497381 Direct association of protein-tyrosine phosphatase PTP-PEST with paxillin. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
37 26895766 Targeting the Metastasis Suppressor, N-Myc Downstream Regulated Gene-1, with Novel Di-2-Pyridylketone Thiosemicarbazones: Suppression of Tumor Cell Migration and Cell-Collagen Adhesion by Inhibiting Focal Adhesion Kinase/Paxillin Signaling. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
38 11857088 PTEN regulates tumor cell adhesion of colon carcinoma cells under dynamic conditions of fluid flow. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
39 25486458 Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
40 10455189 Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
41 22481092 Paxillin phosphorylation and complexing with Erk and FAK are regulated by PLD activity in MDA-MB-231 cells. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
42 24885567 Maternal embryonic leucine zipper kinase enhances gastric cancer progression via the FAK/Paxillin pathway. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
43 15340073 SRC-mediated phosphorylation of focal adhesion kinase couples actin and adhesion dynamics to survival signaling. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
44 15652490 Angiotensin II induces focal adhesion kinase/paxillin phosphorylation and cell migration in human umbilical vein endothelial cells. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
45 11784865 The adaptor protein paxillin is essential for normal development in the mouse and is a critical transducer of fibronectin signaling. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
46 19168634 Stoichiometry of molecular complexes at adhesions in living cells. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
47 8922390 Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
48 21900245 Paxillin enables attachment-independent tyrosine phosphorylation of focal adhesion kinase and transformation by RAS. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
49 18078823 Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
50 10417825 Focal adhesion kinase, paxillin, and bcl-2: analysis of expression, phosphorylation, and association during morphogenesis. Pubmed 4.935E-7 2.674E-5 2.303E-4 1.524E-3 2 3
Show 45 more annotations

9: Interaction [Display Chart] 16 input genes in category / 973 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:ZBTB9 ZBTB9 interactions 9.586E-6 5.977E-3 4.457E-2 9.328E-3 3 47
2 int:NEDD9 NEDD9 interactions 1.228E-5 5.977E-3 4.457E-2 1.195E-2 3 51
3 int:BCAR1 BCAR1 interactions 5.520E-5 1.790E-2
1.335E-1
5.371E-2
 3 84
4 int:SELE SELE interactions 1.751E-4 2.664E-2
1.987E-1
1.703E-1
 2 22
5 int:PXN PXN interactions 1.799E-4 2.664E-2
1.987E-1
1.751E-1
 3 125
6 int:VCL VCL interactions 1.842E-4 2.664E-2
1.987E-1
1.793E-1
 3 126
7 int:ZNF324 ZNF324 interactions 1.916E-4 2.664E-2
1.987E-1
1.865E-1
 2 23
8 int:SYK SYK interactions 2.410E-4 2.798E-2
2.087E-1
2.344E-1
 3 138
9 int:DENND2D DENND2D interactions 2.855E-4 2.798E-2
2.087E-1
2.778E-1
 2 28
10 int:KAT14 KAT14 interactions 3.283E-4 2.798E-2
2.087E-1
3.194E-1
 2 30
11 int:PKD1 PKD1 interactions 3.507E-4 2.798E-2
2.087E-1
3.412E-1
 2 31
12 int:PTPRH PTPRH interactions 3.739E-4 2.798E-2
2.087E-1
3.638E-1
 2 32
13 int:EAF2 EAF2 interactions 3.739E-4 2.798E-2
2.087E-1
3.638E-1
 2 32
14 int:ASAP1 ASAP1 interactions 5.283E-4 3.671E-2
2.738E-1
5.140E-1
 2 38
15 int:TGFB1I1 TGFB1I1 interactions 6.768E-4 4.116E-2
3.069E-1
6.585E-1
 2 43
16 int:TRIM15 TRIM15 interactions 6.768E-4 4.116E-2
3.069E-1
6.585E-1
 2 43
17 int:TRMT6 TRMT6 interactions 8.432E-4 4.499E-2
3.356E-1
8.204E-1
 2 48
18 int:YEATS2 YEATS2 interactions 8.432E-4 4.499E-2
3.356E-1
8.204E-1
 2 48
19 int:SORBS1 SORBS1 interactions 8.786E-4 4.499E-2
3.356E-1
8.549E-1
 2 49
20 int:TAF1D TAF1D interactions 1.106E-3 4.883E-2
3.642E-1
1.000E0
 2 55
21 int:RNF146 RNF146 interactions 1.187E-3 4.883E-2
3.642E-1
1.000E0
 2 57
22 int:ZHX1 ZHX1 interactions 1.187E-3 4.883E-2
3.642E-1
1.000E0
 2 57
23 int:ITGB3 ITGB3 interactions 1.315E-3 4.883E-2
3.642E-1
1.000E0
 2 60
24 int:PPP3CB PPP3CB interactions 1.448E-3 4.883E-2
3.642E-1
1.000E0
 2 63
25 int:SEC23B SEC23B interactions 1.448E-3 4.883E-2
3.642E-1
1.000E0
 2 63
26 int:NF2 NF2 interactions 1.456E-3 4.883E-2
3.642E-1
1.000E0
 3 256
27 int:FERMT2 FERMT2 interactions 1.541E-3 4.883E-2
3.642E-1
1.000E0
 2 65
28 int:ARRB1 ARRB1 interactions 1.573E-3 4.883E-2
3.642E-1
1.000E0
 3 263
29 int:SIRT1 SIRT1 interactions 1.625E-3 4.883E-2
3.642E-1
1.000E0
 3 266
30 int:NEDD8 NEDD8 interactions 1.714E-3 4.883E-2
3.642E-1
1.000E0
 3 271
31 int:CBL CBL interactions 1.714E-3 4.883E-2
3.642E-1
1.000E0
 3 271
32 int:NCR2 NCR2 interactions 1.807E-3 4.883E-2
3.642E-1
1.000E0
 1 2
33 int:ZNF891 ZNF891 interactions 1.807E-3 4.883E-2
3.642E-1
1.000E0
 1 2
34 int:SIGLEC14 SIGLEC14 interactions 1.807E-3 4.883E-2
3.642E-1
1.000E0
 1 2
35 int:TREM1 TREM1 interactions 1.807E-3 4.883E-2
3.642E-1
1.000E0
 1 2
36 int:TREM2 TREM2 interactions 1.807E-3 4.883E-2
3.642E-1
1.000E0
 1 2
37 int:PTPN12 PTPN12 interactions 1.887E-3 4.961E-2
3.700E-1
1.000E0
 2 72
38 int:ASPM ASPM interactions 1.992E-3 4.990E-2
3.722E-1
1.000E0
 2 74
39 int:CRK CRK interactions 2.080E-3 4.990E-2
3.722E-1
1.000E0
 3 290
40 int:CDK9 CDK9 interactions 2.100E-3 4.990E-2
3.722E-1
1.000E0
 3 291
41 int:ITGAV ITGAV interactions 2.154E-3 4.990E-2
3.722E-1
1.000E0
 2 77
42 int:EAF1 EAF1 interactions 2.154E-3 4.990E-2
3.722E-1
1.000E0
 2 77
Show 37 more annotations

10: Cytoband [Display Chart] 16 input genes in category / 16 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 3q12-q13.3 3q12-q13.3 9.230E-4 1.477E-2 4.993E-2 1.477E-2 1 2
2 4q31.22 4q31.22 4.607E-3 2.085E-2
7.050E-2
7.371E-2
 1 10
3 2p16 2p16 5.526E-3 2.085E-2
7.050E-2
8.842E-2
 1 12
4 11q14 11q14 5.526E-3 2.085E-2
7.050E-2
8.842E-2
 1 12
5 8q22 8q22 6.903E-3 2.085E-2
7.050E-2
1.105E-1
 1 15
6 9q31 9q31 7.820E-3 2.085E-2
7.050E-2
1.251E-1
 1 17
7 7q32 7q32 1.102E-2 2.520E-2
8.518E-2
1.764E-1
 1 24
8 4q24 4q24 1.604E-2 3.208E-2
1.084E-1
2.566E-1
 1 35
9 19p13.1 19p13.1 2.193E-2 3.642E-2
1.231E-1
3.509E-1
 1 48
10 12q13.3 12q13.3 2.374E-2 3.642E-2
1.231E-1
3.799E-1
 1 52
11 19q13.1 19q13.1 2.509E-2 3.642E-2
1.231E-1
4.015E-1
 1 55
12 17q21 17q21 2.869E-2 3.642E-2
1.231E-1
4.591E-1
 1 63
13 5q31.1 5q31.1 2.959E-2 3.642E-2
1.231E-1
4.735E-1
 1 65
14 12q24.31 12q24.31 3.675E-2 4.200E-2
1.420E-1
5.880E-1
 1 81
15 2q37.3 2q37.3 3.942E-2 4.205E-2
1.422E-1
6.307E-1
 1 87
Show 10 more annotations

11: Transcription Factor Binding Site [Display Chart] 13 input genes in category / 116 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 12 input genes in category / 12 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 694 Protein phosphatase 1 regulatory subunits genenames.org 1.994E-4 2.393E-3 7.426E-3 2.393E-3 3 181
2 450 UDP-glucose ceramide glucosyltransferases genenames.org 6.596E-4 2.673E-3 8.295E-3 7.915E-3 1 1
3 1218 LIM domain containing genenames.org 6.682E-4 2.673E-3 8.295E-3 8.019E-3 2 59
4 225 Endothelin receptors genenames.org 1.319E-3 3.956E-3 1.228E-2 1.582E-2 1 2
5 556 Fibulins genenames.org 5.265E-3 1.128E-2 3.499E-2
6.318E-2
 1 8
6 1280 Super elongation complex genenames.org 5.922E-3 1.128E-2 3.499E-2
7.106E-2
 1 9
7 822 Synaptotagmin like tandem C2 proteins genenames.org 6.578E-3 1.128E-2 3.499E-2
7.893E-2
 1 10
8 583 Heat shock 70kDa proteins genenames.org 1.116E-2 1.674E-2
5.194E-2
1.339E-1
 1 17
9 690 Proteasome genenames.org 2.800E-2 3.734E-2
1.159E-1
3.360E-1
 1 43
10 1293 Minor histocompatibility antigens|FERM domain containing genenames.org 3.249E-2 3.899E-2
1.210E-1
3.899E-1
 1 50
11 722 Rho guanine nucleotide exchange factors genenames.org 4.269E-2 4.657E-2
1.445E-1
5.122E-1
 1 66
Show 6 more annotations

13: Coexpression [Display Chart] 16 input genes in category / 1884 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16574750-SuppTable2 Human StemCell Song06 74genes GeneSigDB 7.355E-6 1.386E-2
1.125E-1
 1.386E-2 3 56
2 M5321 Cluster 3: ECM related genes up-regulated in dermal fibroblasts within 30 min after TGFB1 [GeneID=7040] addition; returned rapidly to basal level after that. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.060E-5 3.428E-2
2.783E-1
7.650E-2
 2 14
3 20418243-SuppTable1a Human Leukemia Chiaretti10 405genes GeneSigDB 5.458E-5 3.428E-2
2.783E-1
1.028E-1
 4 316
4 M2080 Genes up-regulated by TGFB1 [GeneID=7040] in MEF cells (embryonic fibroblast) via TGFB1R [GeneID=7046]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.584E-5 3.432E-2
2.787E-1
1.617E-1
 3 127
5 M1430 Genes defining differentiation potential of the bipotential myeloid cell line FDB. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.863E-4 3.432E-2
2.787E-1
3.510E-1
 3 165
6 M18436 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G3, defined by unsupervised clustering. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.735E-4 3.432E-2
2.787E-1
5.153E-1
 3 188
7 M15187 Cluster d6: genes progressively down-regulated in WS1 cells (fibroblast) through 18 h after irradiation with high dose UV-C. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.944E-4 3.432E-2
2.787E-1
5.547E-1
 2 37
8 M2721 Genes down-regulated in MCF-7 cells (breast cancer) positive for ESR1 [Gene ID=2099] MCF-7 cells (breast cancer) and long-term adapted for estrogen-independent growth. MSigDB C6: Oncogenic Signatures (v6.0) 3.091E-4 3.432E-2
2.787E-1
5.823E-1
 3 196
9 15705876-TableS5 Human Leukemia Passioura05 44genes GeneSigDB 3.106E-4 3.432E-2
2.787E-1
5.853E-1
 2 38
10 M10828 Human orthologs of genes up-regulated in the crb ('crash and burn') zebrafish mutant that represents a loss-of-function mutation in BMYB [GeneID=4605]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.137E-4 3.432E-2
2.787E-1
5.910E-1
 3 197
11 M4955 Genes down-regulated in comparison of B cells from influenza vaccinee at day 7 versus monocytes from influenza vaccinee at day 7. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
12 M9754 Genes up-regulated in CD4 [GeneID=920] SMARTA effector T cells during acute infection of LCMV: Ly6c int CXCR5+ [GeneID=643] versus Ly6c low CXCR5- [GeneID=643]. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
13 M5924 Genes up-regulated through activation of mTORC1 complex. MSigDB H: Hallmark Gene Sets (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
14 M5808 Genes down-regulated in comparison of untreated macrophages from IRAK4 [GeneID=51135] deficient mice at 4 h versus those treated with LPS (TLR4 agonist) at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
15 M9290 Genes down-regulated in Lung dendritic cell from untreated wildtype mice versus Lung dendritic cell from untreated IL-1R mice. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
16 M9688 Genes down-regulated in CD4 [GeneID=920] T helper cells (60h): Th0 versus Th17 treated with TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
17 M7060 Genes up-regulated in hematopoietic stem cells versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
18 M6904 Genes up-regulated in macrophages with IL10 [GeneID=3586] knockout treated by LPS: 10 min versus 30 min. MSigDB C7: Immunologic Signatures (v6.0) 3.279E-4 3.432E-2
2.787E-1
6.178E-1
 3 200
19 17150101-TableS1i Human Breast Troester06 62genes-down-up DOX-MCF7 GeneSigDB 3.619E-4 3.589E-2
2.913E-1
6.818E-1
 2 41
20 16707422-tableS1b Human Prostate Hendriksen06 60genes GeneSigDB 4.362E-4 4.109E-2
3.336E-1
8.219E-1
 2 45
21 15246160-table3 Human StemCell Shim04 50genes GeneSigDB 4.759E-4 4.270E-2
3.467E-1
8.967E-1
 2 47
22 16474848-SuppTable1 Human Prostate Hooi06 65genes 2FoldChange GeneSigDB 5.189E-4 4.443E-2
3.607E-1
9.776E-1
 3 234
23 15308739-Table1 Human Viral Krishnan04 59genes GeneSigDB 5.826E-4 4.773E-2
3.875E-1
1.000E0
 2 52
Show 18 more annotations

14: Coexpression Atlas [Display Chart] 16 input genes in category / 1878 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/macrophage Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Spleen/macrophage Tabula Muris Consortium 3.186E-5 3.637E-2
2.952E-1
5.983E-2
 3 86
2 Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte C Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte C Top 200 Genes 1.096E-4 3.637E-2
2.952E-1
2.058E-1
 4 357
3 Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte C E18.5 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Pericyte Subtype pericyte C E18.5 Top 200 Genes 1.096E-4 3.637E-2
2.952E-1
2.058E-1
 4 357
4 GSM538288 500 NK cells, NK.49CI-.Sp, NK1.1+ CD3- Ly49C/I-, Spleen, avg-3 Immgen.org, GSE15907 1.284E-4 3.637E-2
2.952E-1
2.412E-1
 4 372
5 GSM538285 500 NK cells, NK.49CI+.Sp, NK1.1+ CD3- Ly49C/I+, Spleen, avg-3 Immgen.org, GSE15907 1.466E-4 3.637E-2
2.952E-1
2.753E-1
 4 385
6 GSM538291 500 NK cells, NK.b2m-.Sp, NK1.1+ TCRb-, Spleen, avg-3 Immgen.org, GSE15907 1.540E-4 3.637E-2
2.952E-1
2.893E-1
 4 390
7 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 200 dev lower uro neuro e15.5 PelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 1.603E-4 3.637E-2
2.952E-1
3.010E-1
 3 148
8 GSM538315 500 NK cells, NK.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 1.849E-4 3.637E-2
2.952E-1
3.472E-1
 4 409
9 GSM605817 500 NK cells, NK.49H-.Sp, NK1.1+, Spleen, avg-3 Immgen.org, GSE15907 1.919E-4 3.637E-2
2.952E-1
3.604E-1
 4 413
10 GSM538303 500 NK cells, NK.H+.MCMV7.Sp, NK1.1+ TCRb- Ly49H+, Spleen, avg-3 Immgen.org, GSE15907 1.937E-4 3.637E-2
2.952E-1
3.637E-1
 4 414
11 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/mature natural killer cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/mature natural killer cell Tabula Muris Consortium 2.412E-4 3.952E-2
3.207E-1
4.530E-1
 3 170
12 GSM777067 500 Stromal Cells, St.31-38-44-.SLN, CD45- gp38- CD31- CD44-, Lymph Node, avg-2 Immgen.org, GSE15907 2.732E-4 3.952E-2
3.207E-1
5.131E-1
 4 453
13 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/granulocyte Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Marrow/granulocyte Tabula Muris Consortium 2.853E-4 3.952E-2
3.207E-1
5.358E-1
 3 180
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Cortex Wilms Nephron epithelium/Kidney Normal-Cortex Wilms N20 Adult, Development, and Cancer types 3.092E-4 3.952E-2
3.207E-1
5.807E-1
 3 185
15 Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/skeletal muscle satellite stem cell Tabula Muris Consortium/Tabula Muris Consortium/Tissues and cell class/Diaphrag/skeletal muscle satellite stem cell Tabula Muris Consortium 3.191E-4 3.952E-2
3.207E-1
5.993E-1
 3 187
16 gudmap dev lower uro neuro e14.5 PelvicGanglion Sox10 200 dev lower uro neuro e14.5 PelvicGanglion Sox10 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 3.554E-4 3.952E-2
3.207E-1
6.674E-1
 3 194
17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Tumour VHL RCC MNP2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP2/Kidney Tumour VHL RCC MNP2 Adult, Development, and Cancer types 3.608E-4 3.952E-2
3.207E-1
6.776E-1
 3 195
18 Lungmap Mouse Lung PND3 Myeloid Subtype Myeloid-A Lungmap Mouse Lung PND3 Myeloid Subtype Myeloid-A Lungmap CCHMC 4.297E-4 3.952E-2
3.207E-1
8.069E-1
 3 207
19 gudmap dev gonad e11.5 M GonadVasMes Flk k4 500 dev gonad e11.5 M GonadVasMes Flk k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse ST 1.0 4.358E-4 3.952E-2
3.207E-1
8.183E-1
 3 208
20 Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte C Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte C Top 200 Genes 4.419E-4 3.952E-2
3.207E-1
8.299E-1
 3 209
21 Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte C E18.5 Top 200 Genes Lungmap Lungmap - Mouse FluidigmC1 Pericyte Pericyte Subtype pericyte C E18.5 Top 200 Genes 4.419E-4 3.952E-2
3.207E-1
8.299E-1
 3 209
22 gudmap dev lower uro neuro e15.5 PelvicGanglion Sox10 k3 200 dev lower uro neuro e15.5 PelvicGanglion Sox10 k-means-cluster#3 top-relative-expression-ranked 200 Gudmap Mouse ST 1.0 4.680E-4 3.995E-2
3.242E-1
8.789E-1
 2 44
Show 17 more annotations

15: Computational [Display Chart] 14 input genes in category / 133 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 16 input genes in category / 584 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-622:PITA hsa-miR-622:PITA TOP PITA 2.140E-5 9.331E-3
6.483E-2
 1.250E-2 3 247
2 hsa-miR-4796-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.310E-5 9.331E-3
6.483E-2
 1.933E-2 3 286
3 hsa-miR-580:PITA hsa-miR-580:PITA TOP PITA 4.793E-5 9.331E-3
6.483E-2
 2.799E-2 3 324
4 hsa-miR-26b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.033E-5 1.027E-2
7.134E-2
 4.107E-2 2 56
5 hsa-miR-27b-3p:Functional MTI Functional MTI miRTarbase 1.040E-4 1.215E-2
8.441E-2
6.074E-2
 3 421
6 hsa-miR-4327:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.072E-4 1.674E-2
1.163E-1
1.210E-1
 2 96
7 hsa-miR-16-1-3p:Functional MTI Functional MTI miRTarbase 2.248E-4 1.674E-2
1.163E-1
1.313E-1
 2 100
8 hsa-miR-1206:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.293E-4 1.674E-2
1.163E-1
1.339E-1
 2 101
9 hsa-miR-328-3p:Functional MTI Functional MTI miRTarbase 3.910E-4 2.537E-2
1.763E-1
2.283E-1
 2 132
10 hsa-miR-28-3p:PITA hsa-miR-28-3p:PITA TOP PITA 6.314E-4 2.792E-2
1.940E-1
3.688E-1
 2 168
11 hsa-miR-365:PITA hsa-miR-365:PITA TOP PITA 6.314E-4 2.792E-2
1.940E-1
3.688E-1
 2 168
12 hsa-miR-7-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.540E-4 2.792E-2
1.940E-1
3.819E-1
 2 171
13 hsa-miR-7-1-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.563E-4 2.792E-2
1.940E-1
4.417E-1
 2 184
14 hsa-miR-516b:PITA hsa-miR-516b:PITA TOP PITA 8.313E-4 2.792E-2
1.940E-1
4.855E-1
 2 193
15 hsa-miR-650:PITA hsa-miR-650:PITA TOP PITA 8.571E-4 2.792E-2
1.940E-1
5.005E-1
 2 196
16 hsa-miR-6850-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.856E-4 2.792E-2
1.940E-1
5.172E-1
 1 4
17 hsa-miR-96-5p:Functional MTI Functional MTI miRTarbase 9.009E-4 2.792E-2
1.940E-1
5.261E-1
 2 201
18 hsa-miR-5590-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.001E-3 2.792E-2
1.940E-1
5.846E-1
 2 212
19 hsa-miR-200c-3p:Functional MTI Functional MTI miRTarbase 1.020E-3 2.792E-2
1.940E-1
5.956E-1
 2 214
20 hsa-miR-411-3p:TargetScan hsa-miR-411-3p TargetScan 1.020E-3 2.792E-2
1.940E-1
5.956E-1
 2 214
21 hsa-miR-379-3p:TargetScan hsa-miR-379-3p TargetScan 1.020E-3 2.792E-2
1.940E-1
5.956E-1
 2 214
22 hsa-miR-142-5p:Functional MTI Functional MTI miRTarbase 1.126E-3 2.792E-2
1.940E-1
6.576E-1
 2 225
23 hsa-miR-7:PITA hsa-miR-7:PITA TOP PITA 1.186E-3 2.792E-2
1.940E-1
6.927E-1
 2 231
24 hsa-miR-744-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.237E-3 2.792E-2
1.940E-1
7.226E-1
 2 236
25 hsa-miR-505:PITA hsa-miR-505:PITA TOP PITA 1.300E-3 2.792E-2
1.940E-1
7.593E-1
 2 242
26 hsa-miR-3681-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.321E-3 2.792E-2
1.940E-1
7.717E-1
 2 244
27 hsa-miR-216a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.321E-3 2.792E-2
1.940E-1
7.717E-1
 2 244
28 ATTCTTT,MIR-186:MSigDB ATTCTTT,MIR-186:MSigDB MSigDB 1.419E-3 2.792E-2
1.940E-1
8.289E-1
 2 253
29 hsa-miR-936:PITA hsa-miR-936:PITA TOP PITA 1.486E-3 2.792E-2
1.940E-1
8.680E-1
 2 259
30 hsa-miR-511-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.509E-3 2.792E-2
1.940E-1
8.813E-1
 2 261
31 hsa-miR-216b-5p:TargetScan hsa-miR-216b-5p TargetScan 1.543E-3 2.792E-2
1.940E-1
9.014E-1
 2 264
32 hsa-miR-1249-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.661E-3 2.792E-2
1.940E-1
9.698E-1
 2 274
33 hsa-miR-6797-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.697E-3 2.792E-2
1.940E-1
9.908E-1
 2 277
34 hsa-miR-223-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.782E-3 2.792E-2
1.940E-1
1.000E0
 2 284
35 hsa-miR-324-5p:Functional MTI Functional MTI miRTarbase 1.946E-3 2.792E-2
1.940E-1
1.000E0
 2 297
36 hsa-miR-4419a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.998E-3 2.792E-2
1.940E-1
1.000E0
 2 301
37 hsa-miR-6130:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.998E-3 2.792E-2
1.940E-1
1.000E0
 2 301
38 hsa-miR-6129:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.011E-3 2.792E-2
1.940E-1
1.000E0
 2 302
39 hsa-miR-4510:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.024E-3 2.792E-2
1.940E-1
1.000E0
 2 303
40 hsa-miR-6127:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.050E-3 2.792E-2
1.940E-1
1.000E0
 2 305
41 hsa-miR-6133:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.050E-3 2.792E-2
1.940E-1
1.000E0
 2 305
42 TTGCCAA,MIR-182:MSigDB TTGCCAA,MIR-182:MSigDB MSigDB 2.063E-3 2.792E-2
1.940E-1
1.000E0
 2 306
43 hsa-miR-671-3p:PITA hsa-miR-671-3p:PITA TOP PITA 2.213E-3 2.792E-2
1.940E-1
1.000E0
 1 10
44 hsa-miR-652:mirSVR lowEffct hsa-miR-652:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 2.225E-3 2.792E-2
1.940E-1
1.000E0
 2 318
45 hsa-miR-548ah-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.239E-3 2.792E-2
1.940E-1
1.000E0
 2 319
46 hsa-miR-3609:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.253E-3 2.792E-2
1.940E-1
1.000E0
 2 320
47 hsa-miR-942:PITA hsa-miR-942:PITA TOP PITA 2.294E-3 2.792E-2
1.940E-1
1.000E0
 2 323
48 hsa-miR-217:TargetScan hsa-miR-217 TargetScan 2.294E-3 2.792E-2
1.940E-1
1.000E0
 2 323
49 hsa-miR-194-5p:TargetScan hsa-miR-194-5p TargetScan 2.393E-3 2.852E-2
1.982E-1
1.000E0
 2 330
50 hsa-miR-216b:PITA hsa-miR-216b:PITA TOP PITA 2.508E-3 2.929E-2
2.035E-1
1.000E0
 2 338
Show 45 more annotations

17: Drug [Display Chart] 16 input genes in category / 4887 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:C072247 cyclo(Trp-Asp-Pro-Val-Leu) CTD 3.930E-6 8.803E-3
7.986E-2
 1.921E-2 3 45
2 ctd:C068805 4-hydroxycoumarin CTD 4.595E-6 8.803E-3
7.986E-2
 2.245E-2 2 5
3 CID000006574 beta T Stitch 8.063E-6 8.803E-3
7.986E-2
 3.941E-2 3 57
4 4844 DN Tolazoline hydrochloride [59-97-2]; Down 200; 20.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 8.828E-6 8.803E-3
7.986E-2
 4.314E-2 4 196
5 2804 DN Boldine [476-70-0]; Down 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 9.007E-6 8.803E-3
7.986E-2
 4.402E-2 4 197
6 ctd:C042743 oxotremorine M CTD 1.285E-5 1.047E-2
9.494E-2
6.280E-2
 2 8
7 CID000025294 chloropyramine Stitch 4.166E-5 2.545E-2
2.309E-1
2.036E-1
 2 14
8 ctd:D000781 Anethole Trithione CTD 4.166E-5 2.545E-2
2.309E-1
2.036E-1
 2 14
9 ctd:C587228 methyl 3-hydroxyimino-11-oxoolean-12-en-28-oate CTD 4.805E-5 2.609E-2
2.367E-1
2.348E-1
 2 15
10 ctd:C434003 3-(4-methylphenylsulfonyl)-2-propenenitrile CTD 6.300E-5 3.079E-2
2.793E-1
3.079E-1
 3 113
11 ctd:C121718 dicyclanil CTD 9.126E-5 3.139E-2
2.848E-1
4.460E-1
 3 128
12 CID000004028 5,8,11-eicosatrienoic acid Stitch 1.054E-4 3.139E-2
2.848E-1
5.151E-1
 2 22
13 CID000072519 nonactin Stitch 1.054E-4 3.139E-2
2.848E-1
5.151E-1
 2 22
14 ctd:C086539 BQ 788 CTD 1.367E-4 3.139E-2
2.848E-1
6.682E-1
 2 25
15 CID000024402 ammonium phosphate Stitch 1.721E-4 3.139E-2
2.848E-1
8.409E-1
 2 28
16 ctd:C041359 terbinafine CTD 1.847E-4 3.139E-2
2.848E-1
9.028E-1
 2 29
17 ctd:C012606 4-vinyl-1-cyclohexene dioxide CTD 2.112E-4 3.139E-2
2.848E-1
1.000E0
 3 170
18 1631 DN 17-AAG; Down 200; 1uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.796E-4 3.139E-2
2.848E-1
1.000E0
 3 187
19 ctd:D000069439 Dasatinib CTD 2.823E-4 3.139E-2
2.848E-1
1.000E0
 4 478
20 CID000482568 AC1LA6WX Stitch 2.858E-4 3.139E-2
2.848E-1
1.000E0
 2 36
21 2800 DN Protoveratrine A [143-57-7]; Down 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.884E-4 3.139E-2
2.848E-1
1.000E0
 3 189
22 1103 UP colcemid; Up 200; 11.7uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 2.929E-4 3.139E-2
2.848E-1
1.000E0
 3 190
23 4385 DN Thiostrepton [1393-48-2]; Down 200; 2.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 2.929E-4 3.139E-2
2.848E-1
1.000E0
 3 190
24 2271 DN Hyoscyamine (L) [101-31-5]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.021E-4 3.139E-2
2.848E-1
1.000E0
 3 192
25 6749 DN Zaprinast [37762-06-4]; Down 200; 14.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.067E-4 3.139E-2
2.848E-1
1.000E0
 3 193
26 4226 DN Isoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Down 200; 16.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.067E-4 3.139E-2
2.848E-1
1.000E0
 3 193
27 1924 DN Naloxone hydrochloride [357-08-4]; Down 200; 11uM; PC3; HG-U133A Broad Institute CMAP Down 3.114E-4 3.139E-2
2.848E-1
1.000E0
 3 194
28 6072 DN Etanidazole [22668-01-5]; Down 200; 18.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.114E-4 3.139E-2
2.848E-1
1.000E0
 3 194
29 4335 DN Indapamide [26807-65-8]; Down 200; 10.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.114E-4 3.139E-2
2.848E-1
1.000E0
 3 194
30 1676 DN Morantel tartrate [26155-31-7]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.114E-4 3.139E-2
2.848E-1
1.000E0
 3 194
31 1239 DN LY 294002; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.161E-4 3.139E-2
2.848E-1
1.000E0
 3 195
32 4820 DN Gabazine [105538-73-6]; Down 200; 10.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.161E-4 3.139E-2
2.848E-1
1.000E0
 3 195
33 6255 DN Spironolactone [52-01-7]; Down 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.161E-4 3.139E-2
2.848E-1
1.000E0
 3 195
34 4235 DN Doxylamine succinate [562-10-7]; Down 200; 10.2uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.161E-4 3.139E-2
2.848E-1
1.000E0
 3 195
35 425 DN staurosporine; Down 200; 0.01uM; MCF7; HG-U133A Broad Institute CMAP Down 3.209E-4 3.139E-2
2.848E-1
1.000E0
 3 196
36 3222 DN Methylergometrine maleate [113-42-8]; Down 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.209E-4 3.139E-2
2.848E-1
1.000E0
 3 196
37 1686 DN Acetazolamide [59-66-5]; Down 200; 18uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.209E-4 3.139E-2
2.848E-1
1.000E0
 3 196
38 3768 DN Methyl benzethonium chloride [25155-18-4]; Down 200; 8.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.257E-4 3.139E-2
2.848E-1
1.000E0
 3 197
39 1109 UP 3-hydroxy-(D/L)-kynurenine; Up 200; 9.2uM; MCF7; HT HG-U133A EA Broad Institute CMAP Up 3.257E-4 3.139E-2
2.848E-1
1.000E0
 3 197
40 3561 DN Ciprofibrate [52214-84-3]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.257E-4 3.139E-2
2.848E-1
1.000E0
 3 197
41 4336 DN Phentolamine hydrochloride [73-05-2]; Down 200; 12.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.257E-4 3.139E-2
2.848E-1
1.000E0
 3 197
42 4963 DN Protoveratrine A [143-57-7]; Down 200; 5uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.257E-4 3.139E-2
2.848E-1
1.000E0
 3 197
43 7231 DN Azaperone [1649-18-9]; Down 200; 12.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.257E-4 3.139E-2
2.848E-1
1.000E0
 3 197
44 5251 DN Enoxacin [74011-58-8]; Down 200; 12.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.306E-4 3.139E-2
2.848E-1
1.000E0
 3 198
45 4194 DN Pyrimethamine [58-14-0]; Down 200; 16uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.306E-4 3.139E-2
2.848E-1
1.000E0
 3 198
46 6341 DN Trifluoperazine dihydrochloride [440-17-5]; Down 200; 8.4uM; PC3; HT HG-U133A Broad Institute CMAP Down 3.306E-4 3.139E-2
2.848E-1
1.000E0
 3 198
47 1690 DN Betazole hydrochloride; Down 200; 27uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.306E-4 3.139E-2
2.848E-1
1.000E0
 3 198
48 7219 DN Atropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.355E-4 3.139E-2
2.848E-1
1.000E0
 3 199
49 165 DN exemestane; Down 200; 0.01uM; MCF7; HG-U133A Broad Institute CMAP Down 3.355E-4 3.139E-2
2.848E-1
1.000E0
 3 199
50 5242 DN Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT HG-U133A Broad Institute CMAP Down 3.355E-4 3.139E-2
2.848E-1
1.000E0
 3 199
Show 45 more annotations

18: Disease [Display Chart] 15 input genes in category / 418 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C1850053 Leukodystrophy, hypomyelinating 3 Clinical Variations 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
2 C3279322 Joint contractures, progressive DisGeNET Curated 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
3 C4024769 Reticular pigmentary degeneration DisGeNET Curated 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
4 C4225180 EVEN-PLUS SYNDROME DisGeNET Curated 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
5 OMIN:126600 DOYNE HONEYCOMB RETINAL DYSTROPHY; DHRD OMIM 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
6 C0279734 pituitary eosinophilic adenoma DisGeNET BeFree 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
7 C0221151 Projectile vomiting DisGeNET Curated 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
8 cv:C1832174 Doyne honeycomb retinal dystrophy Clinical Variations 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
9 C4225349 MANDIBULOFACIAL DYSOSTOSIS WITH ALOPECIA DisGeNET Curated 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
10 C1850053 Pelizaeus-Merzbacher-like disease, autosomal recessive, 2 DisGeNET Curated 9.256E-4 3.869E-2
2.559E-1
3.869E-1
 1 1
11 C0856169 Endothelial dysfunction DisGeNET BeFree 1.664E-3 4.550E-2
3.009E-1
6.956E-1
 3 263
12 cv:C1857316 Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy Clinical Variations 1.850E-3 4.550E-2
3.009E-1
7.735E-1
 1 2
13 C0151445 Primary Raynaud Phenomenon DisGeNET BeFree 1.850E-3 4.550E-2
3.009E-1
7.735E-1
 1 2
14 C0410533 Osteodysplasia DisGeNET BeFree 1.850E-3 4.550E-2
3.009E-1
7.735E-1
 1 2
15 C4274077 Autosomal recessive sideroblastic anemia DisGeNET Curated 1.850E-3 4.550E-2
3.009E-1
7.735E-1
 1 2
16 C1533163 Disorder of cellular component of blood DisGeNET BeFree 1.850E-3 4.550E-2
3.009E-1
7.735E-1
 1 2
17 OMIN:221770 POLYCYSTIC LIPOMEMBRANOUS OSTEODYSPLASIA WITH SCLEROSING LEUKOENCEPHALOPATHY; PLOSL OMIM 1.850E-3 4.550E-2
3.009E-1
7.735E-1
 1 2
Show 12 more annotations