Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc174_19, positive side

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Display pValues and Scores as Table row limit

1: GO: Molecular Function [Display Chart] 19 input genes in category / 100 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005484 SNAP receptor activity 5.463E-50 5.463E-48 2.834E-47 5.463E-48 18 38
2 GO:0000149 SNARE binding 1.485E-38 7.427E-37 3.852E-36 1.485E-36 18 134
3 GO:0019905 syntaxin binding 3.115E-14 1.038E-12 5.387E-12 3.115E-12 8 98
4 GO:0019869 chloride channel inhibitor activity 7.488E-8 1.872E-6 9.710E-6 7.488E-6 3 9
5 GO:0017081 chloride channel regulator activity 6.030E-7 1.206E-5 6.256E-5 6.030E-5 3 17
6 GO:0008200 ion channel inhibitor activity 7.991E-6 1.330E-4 6.898E-4 7.991E-4 3 39
7 GO:0016248 channel inhibitor activity 9.309E-6 1.330E-4 6.898E-4 9.309E-4 3 41
8 GO:0017075 syntaxin-1 binding 1.846E-4 2.307E-3 1.197E-2 1.846E-2 2 20
9 GO:0016247 channel regulator activity 3.591E-4 3.990E-3 2.070E-2 3.591E-2 3 139
10 GO:0016230 sphingomyelin phosphodiesterase activator activity 2.035E-3 1.751E-2
9.082E-2
2.035E-1
 1 2
11 GO:0035620 ceramide transporter activity 2.035E-3 1.751E-2
9.082E-2
2.035E-1
 1 2
12 GO:0017022 myosin binding 2.150E-3 1.751E-2
9.082E-2
2.150E-1
 2 68
13 GO:0048306 calcium-dependent protein binding 2.276E-3 1.751E-2
9.082E-2
2.276E-1
 2 70
14 GO:0097001 ceramide binding 4.067E-3 2.905E-2
1.507E-1
4.067E-1
 1 4
15 GO:0046624 sphingolipid transporter activity 6.094E-3 4.063E-2
2.108E-1
6.094E-1
 1 6
16 GO:0050544 arachidonic acid binding 7.107E-3 4.442E-2
2.304E-1
7.107E-1
 1 7
17 GO:0050543 icosatetraenoic acid binding 8.118E-3 4.775E-2
2.477E-1
8.118E-1
 1 8
18 GO:0050542 icosanoid binding 9.128E-3 4.804E-2
2.492E-1
9.128E-1
 1 9
19 GO:1901567 fatty acid derivative binding 9.128E-3 4.804E-2
2.492E-1
9.128E-1
 1 9
20 GO:0016004 phospholipase activator activity 1.215E-2 4.938E-2
2.562E-1
1.000E0
 1 12
21 GO:0060229 lipase activator activity 1.417E-2 4.938E-2
2.562E-1
1.000E0
 1 14
22 GO:0046625 sphingolipid binding 1.617E-2 4.938E-2
2.562E-1
1.000E0
 1 16
23 GO:0036041 long-chain fatty acid binding 1.818E-2 4.938E-2
2.562E-1
1.000E0
 1 18
24 GO:0070273 phosphatidylinositol-4-phosphate binding 2.217E-2 4.938E-2
2.562E-1
1.000E0
 1 22
25 GO:0019706 protein-cysteine S-palmitoyltransferase activity 2.516E-2 4.938E-2
2.562E-1
1.000E0
 1 25
26 GO:0052858 peptidyl-lysine acetyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
27 GO:0034945 2,6-dimethyl-5-methylene-3-oxo-heptanoyl-CoA C-acetyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
28 GO:0016753 O-sinapoyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
29 GO:0018031 peptidyl-lysine N6-palmitoyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
30 GO:0043741 L-2-aminoadipate N-acetyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
31 GO:0034919 butyryl-CoA 2-C-propionyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
32 GO:0043806 keto acid formate lyase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
33 GO:0019705 protein-cysteine S-myristoyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
34 GO:0018030 peptidyl-lysine N6-myristoyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
35 GO:0046941 azetidine-2-carboxylic acid acetyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
36 GO:0016412 serine O-acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
37 GO:0034737 ergosterol O-acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
38 GO:0090595 acetyl-CoA:L-lysine N6-acetyltransferase 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
39 GO:0016750 O-succinyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
40 GO:0016752 sinapoyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
41 GO:0034915 2-methylhexanoyl-CoA C-acetyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
42 GO:0008951 palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
43 GO:0034738 lanosterol O-acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
44 GO:0032216 glucosaminyl-phosphotidylinositol O-acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
45 GO:0019186 acyl-CoA N-acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
46 GO:0018711 benzoyl acetate-CoA thiolase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
47 GO:0004147 dihydrolipoamide branched chain acyltransferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
48 GO:0018713 3-ketopimelyl-CoA thiolase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
49 GO:0034848 naphthyl-2-oxomethyl-succinyl-CoA succinyl transferase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
50 GO:0018712 3-hydroxybutyryl-CoA thiolase activity 2.913E-2 4.938E-2
2.562E-1
1.000E0
 1 29
Show 45 more annotations

2: GO: Biological Process [Display Chart] 19 input genes in category / 363 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0006906 vesicle fusion 1.725E-37 4.016E-35 2.600E-34 6.260E-35 18 152
2 GO:0090174 organelle membrane fusion 2.213E-37 4.016E-35 2.600E-34 8.033E-35 18 154
3 GO:0048284 organelle fusion 3.757E-35 4.545E-33 2.942E-32 1.364E-32 18 202
4 GO:0061025 membrane fusion 2.837E-34 2.574E-32 1.666E-31 1.030E-31 18 225
5 GO:0016050 vesicle organization 1.209E-30 8.778E-29 5.682E-28 4.389E-28 18 353
6 GO:0048278 vesicle docking 1.916E-26 1.159E-24 7.502E-24 6.953E-24 12 60
7 GO:0022406 membrane docking 2.505E-25 1.299E-23 8.410E-23 9.095E-23 12 73
8 GO:0048193 Golgi vesicle transport 5.080E-17 2.305E-15 1.492E-14 1.844E-14 12 340
9 GO:0006887 exocytosis 1.072E-15 4.322E-14 2.798E-13 3.890E-13 12 438
10 GO:0099500 vesicle fusion to plasma membrane 2.333E-15 7.699E-14 4.984E-13 8.469E-13 6 15
11 GO:0031629 synaptic vesicle fusion to presynaptic active zone membrane 2.333E-15 7.699E-14 4.984E-13 8.469E-13 6 15
12 GO:0017156 calcium ion regulated exocytosis 3.194E-15 9.663E-14 6.255E-13 1.160E-12 9 133
13 GO:0006892 post-Golgi vesicle-mediated transport 2.449E-14 6.840E-13 4.427E-12 8.891E-12 8 95
14 GO:0051656 establishment of organelle localization 6.864E-14 1.780E-12 1.152E-11 2.492E-11 11 438
15 GO:0045026 plasma membrane fusion 4.181E-13 1.012E-11 6.550E-11 1.518E-10 6 32
16 GO:0042147 retrograde transport, endosome to Golgi 5.671E-13 1.287E-11 8.328E-11 2.058E-10 7 74
17 GO:0051650 establishment of vesicle localization 1.083E-12 2.312E-11 1.496E-10 3.930E-10 9 252
18 GO:0006904 vesicle docking involved in exocytosis 1.763E-12 3.484E-11 2.255E-10 6.398E-10 6 40
19 GO:0051648 vesicle localization 1.823E-12 3.484E-11 2.255E-10 6.619E-10 9 267
20 GO:0016079 synaptic vesicle exocytosis 2.333E-12 4.235E-11 2.741E-10 8.469E-10 7 90
21 GO:0007009 plasma membrane organization 3.955E-12 6.836E-11 4.425E-10 1.436E-9 9 291
22 GO:0045055 regulated exocytosis 8.053E-12 1.329E-10 8.601E-10 2.923E-9 9 315
23 GO:0099504 synaptic vesicle cycle 1.937E-11 3.058E-10 1.979E-9 7.033E-9 7 121
24 GO:0072659 protein localization to plasma membrane 2.702E-11 4.087E-10 2.646E-9 9.809E-9 8 225
25 GO:1990778 protein localization to cell periphery 2.901E-11 4.212E-10 2.726E-9 1.053E-8 8 227
26 GO:0048489 synaptic vesicle transport 3.791E-11 5.097E-10 3.299E-9 1.376E-8 7 133
27 GO:0097480 establishment of synaptic vesicle localization 3.791E-11 5.097E-10 3.299E-9 1.376E-8 7 133
28 GO:0097479 synaptic vesicle localization 5.733E-11 7.432E-10 4.811E-9 2.081E-8 7 141
29 GO:1904375 regulation of protein localization to cell periphery 6.456E-11 7.811E-10 5.056E-9 2.343E-8 6 71
30 GO:1903076 regulation of protein localization to plasma membrane 6.456E-11 7.811E-10 5.056E-9 2.343E-8 6 71
31 GO:0016197 endosomal transport 8.319E-11 9.742E-10 6.306E-9 3.020E-8 8 259
32 GO:1903729 regulation of plasma membrane organization 1.347E-10 1.528E-9 9.893E-9 4.890E-8 6 80
33 GO:0099643 signal release from synapse 1.595E-10 1.703E-9 1.102E-8 5.789E-8 7 163
34 GO:0007269 neurotransmitter secretion 1.595E-10 1.703E-9 1.102E-8 5.789E-8 7 163
35 GO:0007034 vacuolar transport 1.936E-10 2.008E-9 1.300E-8 7.028E-8 8 288
36 GO:0099531 presynaptic process involved in chemical synaptic transmission 2.424E-10 2.366E-9 1.531E-8 8.800E-8 7 173
37 GO:0002349 histamine production involved in inflammatory response 2.542E-10 2.366E-9 1.531E-8 9.226E-8 4 11
38 GO:0002441 histamine secretion involved in inflammatory response 2.542E-10 2.366E-9 1.531E-8 9.226E-8 4 11
39 GO:0002553 histamine secretion by mast cell 2.542E-10 2.366E-9 1.531E-8 9.226E-8 4 11
40 GO:0023061 signal release 4.738E-10 4.300E-9 2.783E-8 1.720E-7 9 498
41 GO:0006836 neurotransmitter transport 1.007E-9 8.913E-9 5.770E-8 3.655E-7 7 212
42 GO:0001505 regulation of neurotransmitter levels 1.075E-9 9.291E-9 6.014E-8 3.902E-7 7 214
43 GO:0035493 SNARE complex assembly 1.397E-9 1.179E-8 7.635E-8 5.072E-7 4 16
44 GO:0001821 histamine secretion 1.826E-9 1.506E-8 9.751E-8 6.628E-7 4 17
45 GO:0051608 histamine transport 2.970E-9 2.396E-8 1.551E-7 1.078E-6 4 19
46 GO:0043299 leukocyte degranulation 9.615E-9 7.587E-8 4.911E-7 3.490E-6 5 74
47 GO:0045117 azole transport 1.338E-8 1.033E-7 6.688E-7 4.856E-6 4 27
48 GO:0002275 myeloid cell activation involved in immune response 1.429E-8 1.081E-7 6.997E-7 5.189E-6 5 80
49 GO:1903593 regulation of histamine secretion by mast cell 1.797E-8 1.331E-7 8.618E-7 6.524E-6 3 6
50 GO:0002444 myeloid leukocyte mediated immunity 2.902E-8 2.107E-7 1.364E-6 1.053E-5 5 92
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 19 input genes in category / 105 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0031201 SNARE complex 1.076E-46 1.129E-44 5.913E-44 1.129E-44 18 54
2 GO:0030133 transport vesicle 9.418E-15 4.945E-13 2.589E-12 9.889E-13 11 374
3 GO:0098793 presynapse 2.358E-13 8.254E-12 4.322E-11 2.476E-11 10 341
4 GO:0005802 trans-Golgi network 1.622E-11 4.257E-10 2.229E-9 1.703E-9 8 216
5 GO:0008021 synaptic vesicle 9.968E-11 2.093E-9 1.096E-8 1.047E-8 7 156
6 GO:0070382 exocytic vesicle 1.982E-10 3.469E-9 1.816E-8 2.081E-8 7 172
7 GO:0098791 Golgi subcompartment 4.312E-10 6.468E-9 3.387E-8 4.528E-8 8 326
8 GO:0031984 organelle subcompartment 6.155E-10 8.079E-9 4.230E-8 6.463E-8 8 341
9 GO:0043195 terminal bouton 9.165E-10 1.069E-8 5.599E-8 9.623E-8 6 112
10 GO:0032588 trans-Golgi network membrane 1.444E-8 1.516E-7 7.940E-7 1.516E-6 5 82
11 GO:0043679 axon terminus 1.944E-8 1.856E-7 9.718E-7 2.042E-6 6 186
12 GO:0044306 neuron projection terminus 2.910E-8 2.546E-7 1.333E-6 3.055E-6 6 199
13 GO:0030135 coated vesicle 9.076E-8 7.330E-7 3.838E-6 9.529E-6 6 241
14 GO:0055037 recycling endosome 2.130E-7 1.597E-6 8.363E-6 2.236E-5 5 140
15 GO:0030662 coated vesicle membrane 2.286E-7 1.600E-6 8.378E-6 2.400E-5 5 142
16 GO:0042581 specific granule 3.035E-7 1.992E-6 1.043E-5 3.187E-5 3 14
17 GO:0033267 axon part 3.928E-7 2.426E-6 1.270E-5 4.124E-5 6 309
18 GO:0005766 primary lysosome 6.787E-7 3.751E-6 1.964E-5 7.127E-5 3 18
19 GO:0042582 azurophil granule 6.787E-7 3.751E-6 1.964E-5 7.127E-5 3 18
20 GO:0042588 zymogen granule 1.677E-6 8.805E-6 4.610E-5 1.761E-4 3 24
21 GO:0030141 secretory granule 1.771E-6 8.854E-6 4.636E-5 1.859E-4 6 400
22 GO:0031902 late endosome membrane 3.538E-6 1.689E-5 8.841E-5 3.715E-4 4 108
23 GO:0000322 storage vacuole 5.641E-6 2.575E-5 1.348E-4 5.924E-4 2 4
24 GO:0030658 transport vesicle membrane 1.599E-5 6.994E-5 3.662E-4 1.679E-3 4 158
25 GO:0030136 clathrin-coated vesicle 1.764E-5 7.409E-5 3.879E-4 1.852E-3 4 162
26 GO:0012507 ER to Golgi transport vesicle membrane 2.132E-5 8.610E-5 4.508E-4 2.238E-3 3 55
27 GO:0010008 endosome membrane 3.578E-5 1.391E-4 7.285E-4 3.756E-3 5 399
28 GO:0030134 COPII-coated ER to Golgi transport vesicle 4.598E-5 1.724E-4 9.028E-4 4.828E-3 3 71
29 GO:0044440 endosomal part 5.341E-5 1.934E-4 1.013E-3 5.608E-3 5 434
30 GO:0005770 late endosome 6.265E-5 2.193E-4 1.148E-3 6.579E-3 4 224
31 GO:0042589 zymogen granule membrane 8.505E-5 2.881E-4 1.508E-3 8.931E-3 2 14
32 GO:0030667 secretory granule membrane 9.033E-5 2.964E-4 1.552E-3 9.484E-3 3 89
33 GO:0030027 lamellipodium 7.896E-4 2.512E-3 1.315E-2
8.291E-2
 3 186
34 GO:0098594 mucin granule 9.968E-4 3.078E-3 1.612E-2
1.047E-1
 1 1
35 GO:0016323 basolateral plasma membrane 1.725E-3 5.171E-3 2.708E-2
1.812E-1
 3 244
36 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane 1.773E-3 5.171E-3 2.708E-2
1.862E-1
 2 63
37 GO:1990796 photoreceptor cell terminal bouton 1.993E-3 5.655E-3 2.961E-2
2.092E-1
 1 2
38 GO:0098852 lytic vacuole membrane 2.476E-3 6.666E-3 3.490E-2
2.600E-1
 3 277
39 GO:0005765 lysosomal membrane 2.476E-3 6.666E-3 3.490E-2
2.600E-1
 3 277
40 GO:0005776 autophagosome 2.981E-3 7.286E-3 3.815E-2
3.130E-1
 2 82
41 GO:0097441 basal dendrite 2.988E-3 7.286E-3 3.815E-2
3.137E-1
 1 3
42 GO:0020016 ciliary pocket 2.988E-3 7.286E-3 3.815E-2
3.137E-1
 1 3
43 GO:0020018 ciliary pocket membrane 2.988E-3 7.286E-3 3.815E-2
3.137E-1
 1 3
44 GO:0030665 clathrin-coated vesicle membrane 3.053E-3 7.286E-3 3.815E-2
3.206E-1
 2 83
45 GO:0045335 phagocytic vesicle 3.424E-3 7.990E-3 4.183E-2
3.595E-1
 2 88
46 GO:0005769 early endosome 3.528E-3 8.053E-3 4.217E-2
3.704E-1
 3 314
47 GO:0060203 clathrin-sculpted glutamate transport vesicle membrane 3.982E-3 8.197E-3 4.292E-2
4.181E-1
 1 4
48 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex 3.982E-3 8.197E-3 4.292E-2
4.181E-1
 1 4
49 GO:0035577 azurophil granule membrane 3.982E-3 8.197E-3 4.292E-2
4.181E-1
 1 4
50 GO:0070033 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex 3.982E-3 8.197E-3 4.292E-2
4.181E-1
 1 4
Show 45 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 246 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 14 input genes in category / 361 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0020548 decreased optic chiasm size 5.089E-6 1.836E-3 1.187E-2 1.837E-3 2 3
2 MP:0008492 dorsal root ganglion degeneration 1.017E-5 1.836E-3 1.187E-2 3.671E-3 2 4
3 MP:0006409 vestibular ganglion hypoplasia 1.694E-5 2.038E-3 1.318E-2 6.114E-3 2 5
4 MP:0020547 abnormal optic chiasm size 2.538E-5 2.291E-3 1.482E-2 9.164E-3 2 6
5 MP:0004298 vestibular ganglion degeneration 3.551E-5 2.564E-3 1.658E-2 1.282E-2 2 7
6 MP:0001088 small nodose ganglion 7.592E-5 4.568E-3 2.954E-2 2.741E-2 2 10
7 MP:0001085 small petrosal ganglion 9.272E-5 4.781E-3 3.092E-2 3.347E-2 2 11
8 MP:0001087 abnormal nodose ganglion morphology 1.313E-4 5.023E-3 3.248E-2 4.739E-2 2 13
9 MP:0001083 small geniculate ganglion 1.313E-4 5.023E-3 3.248E-2 4.739E-2 2 13
10 MP:0008504 abnormal adrenal chromaffin cell morphology 1.530E-4 5.023E-3 3.248E-2
5.525E-2
 2 14
11 MP:0004267 abnormal optic tract morphology 1.530E-4 5.023E-3 3.248E-2
5.525E-2
 2 14
12 MP:0003987 small vestibular ganglion 1.765E-4 5.308E-3 3.433E-2
6.370E-2
 2 15
13 MP:0001084 abnormal petrosal ganglion morphology 2.015E-4 5.596E-3 3.619E-2
7.274E-2
 2 16
14 MP:0008223 absent hippocampal commissure 2.565E-4 6.615E-3 4.278E-2
9.261E-2
 2 18
15 MP:0009770 abnormal optic chiasm morphology 3.861E-4 8.973E-3
5.803E-2
1.394E-1
 2 22
16 MP:0001093 small trigeminal ganglion 4.226E-4 8.973E-3
5.803E-2
1.525E-1
 2 23
17 MP:0010913 abnormal neuroendocrine cell morphology 4.226E-4 8.973E-3
5.803E-2
1.525E-1
 2 23
18 MP:0001082 abnormal geniculate ganglion morphology 4.606E-4 9.238E-3
5.975E-2
1.663E-1
 2 24
19 MP:0008289 abnormal adrenal medulla morphology 5.003E-4 9.505E-3
6.148E-2
1.806E-1
 2 25
20 MP:0008227 absent anterior commissure 5.416E-4 9.775E-3
6.322E-2
1.955E-1
 2 26
21 MP:0005464 abnormal platelet physiology 5.941E-4 1.021E-2
6.605E-2
2.145E-1
 3 127
22 MP:0002856 abnormal vestibular ganglion morphology 8.227E-4 1.288E-2
8.329E-2
2.970E-1
 2 32
23 MP:0008221 abnormal hippocampal commissure morphology 8.751E-4 1.288E-2
8.329E-2
3.159E-1
 2 33
24 MP:0001096 abnormal glossopharyngeal ganglion morphology 8.751E-4 1.288E-2
8.329E-2
3.159E-1
 2 33
25 MP:0002910 abnormal excitatory postsynaptic currents 8.918E-4 1.288E-2
8.329E-2
3.219E-1
 3 146
26 MP:0013955 increased colon length 1.352E-3 1.877E-2
1.214E-1
4.881E-1
 1 1
27 MP:0000461 decreased presacral vertebrae number 1.485E-3 1.986E-2
1.284E-1
5.361E-1
 2 43
28 MP:0000781 decreased corpus callosum size 2.420E-3 3.040E-2
1.966E-1
8.735E-1
 2 55
29 MP:0020573 abnormal corpus callosum size 2.507E-3 3.040E-2
1.966E-1
9.052E-1
 2 56
30 MP:0001011 abnormal superior cervical ganglion morphology 2.597E-3 3.040E-2
1.966E-1
9.373E-1
 2 57
31 MP:0013957 increased small intestine length 2.702E-3 3.040E-2
1.966E-1
9.755E-1
 1 2
32 MP:0013959 increased large intestine length 2.702E-3 3.040E-2
1.966E-1
9.755E-1
 1 2
33 MP:0001092 abnormal trigeminal ganglion morphology 2.779E-3 3.040E-2
1.966E-1
1.000E0
 2 59
34 MP:0008317 abnormal paravertebral ganglion morphology 3.065E-3 3.254E-2
2.104E-1
1.000E0
 2 62
35 MP:0008225 abnormal anterior commissure morphology 3.262E-3 3.271E-2
2.116E-1
1.000E0
 2 64
36 MP:0008220 abnormal ventral commissure morphology 3.262E-3 3.271E-2
2.116E-1
1.000E0
 2 64
37 MP:0001008 abnormal sympathetic ganglion morphology 3.569E-3 3.483E-2
2.252E-1
1.000E0
 2 67
38 MP:0002961 abnormal axon guidance 3.999E-3 3.567E-2
2.307E-1
1.000E0
 2 71
39 MP:0004646 decreased cervical vertebrae number 4.051E-3 3.567E-2
2.307E-1
1.000E0
 1 3
40 MP:0013954 increased intestine length 4.051E-3 3.567E-2
2.307E-1
1.000E0
 1 3
41 MP:0014081 branched small intestinal villi 4.051E-3 3.567E-2
2.307E-1
1.000E0
 1 3
42 MP:0001007 abnormal sympathetic system morphology 4.807E-3 4.132E-2
2.672E-1
1.000E0
 2 78
43 MP:0004155 decreased susceptibility to induced pancreatitis 5.398E-3 4.532E-2
2.931E-1
1.000E0
 1 4
44 MP:0005445 abnormal neurotransmitter secretion 5.554E-3 4.557E-2
2.947E-1
1.000E0
 2 84
45 MP:0002551 abnormal blood coagulation 5.764E-3 4.613E-2
2.984E-1
1.000E0
 3 281
46 MP:0009676 abnormal hemostasis 5.878E-3 4.613E-2
2.984E-1
1.000E0
 3 283
47 MP:0003651 abnormal axon extension 6.081E-3 4.670E-2
3.021E-1
1.000E0
 2 88
Show 42 more annotations

6: Domain [Display Chart] 19 input genes in category / 47 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM00397 t SNARE SMART 2.402E-36 1.129E-34 5.011E-34 1.129E-34 13 22
2 IPR000727 T SNARE dom InterPro 3.271E-34 7.686E-33 3.411E-32 1.537E-32 13 29
3 IPR010989 t-SNARE InterPro 1.755E-31 2.750E-30 1.221E-29 8.251E-30 13 43
4 PF05739 SNARE Pfam 1.065E-29 1.251E-28 5.554E-28 5.006E-28 11 21
5 PS50192 T SNARE PROSITE 2.328E-28 2.189E-27 9.714E-27 1.094E-26 11 26
6 IPR006012 Syntaxin/epimorphin CS InterPro 1.347E-24 9.042E-24 4.013E-23 6.329E-23 9 16
7 PS00914 SYNTAXIN PROSITE 1.347E-24 9.042E-24 4.013E-23 6.329E-23 9 16
8 PF00804 Syntaxin Pfam 2.083E-16 1.223E-15 5.430E-15 9.788E-15 6 11
9 IPR006011 Syntaxin N InterPro 4.163E-16 2.174E-15 9.647E-15 1.956E-14 6 12
10 PS00417 SYNAPTOBREVIN PROSITE 3.381E-14 1.589E-13 7.052E-13 1.589E-12 5 8
11 SM00503 SynN SMART 7.602E-14 3.248E-13 1.442E-12 3.573E-12 5 9
12 PF00957 Synaptobrevin Pfam 2.784E-13 1.090E-12 4.839E-12 1.308E-11 5 11
13 PS50892 V SNARE PROSITE 4.770E-13 1.724E-12 7.653E-12 2.242E-11 5 12
14 IPR001388 Synaptobrevin InterPro 7.746E-13 2.600E-12 1.154E-11 3.640E-11 5 13
15 IPR016444 Synaptobrevin/VAMP InterPro 1.131E-11 3.545E-11 1.573E-10 5.318E-10 4 6
16 1.10.3840.10 - Gene3D 5.274E-11 1.549E-10 6.875E-10 2.479E-9 4 8
17 IPR015260 Syntaxin-6 N InterPro 9.744E-7 2.544E-6 1.129E-5 4.580E-5 2 2
18 PF09177 Syntaxin-6 N Pfam 9.744E-7 2.544E-6 1.129E-5 4.580E-5 2 2
19 PF00835 SNAP-25 Pfam 2.921E-6 6.865E-6 3.047E-5 1.373E-4 2 3
20 IPR000928 SNAP-25 InterPro 2.921E-6 6.865E-6 3.047E-5 1.373E-4 2 3
21 IPR007705 Vesicle trsprt v-SNARE N InterPro 5.839E-6 1.248E-5 5.536E-5 2.745E-4 2 4
22 PF05008 V-SNARE Pfam 5.839E-6 1.248E-5 5.536E-5 2.745E-4 2 4
23 IPR021538 Syntaxin-5 N InterPro 1.014E-3 1.833E-3 8.136E-3 4.766E-2 1 1
24 PF11416 Syntaxin-5 N Pfam 1.014E-3 1.833E-3 8.136E-3 4.766E-2 1 1
25 IPR028671 STX2 InterPro 1.014E-3 1.833E-3 8.136E-3 4.766E-2 1 1
26 IPR031186 Stx3 InterPro 1.014E-3 1.833E-3 8.136E-3 4.766E-2 1 1
27 IPR028669 STX1A/1B InterPro 2.027E-3 3.286E-3 1.458E-2
9.528E-2
 1 2
28 IPR015708 STX19 InterPro 2.027E-3 3.286E-3 1.458E-2
9.528E-2
 1 2
29 IPR027027 GOSR2/Membrin/Bos1 InterPro 2.027E-3 3.286E-3 1.458E-2
9.528E-2
 1 2
30 SM01270 Longin SMART 5.061E-3 6.996E-3 3.105E-2
2.379E-1
 1 5
31 IPR010908 Longin dom InterPro 5.061E-3 6.996E-3 3.105E-2
2.379E-1
 1 5
32 3.30.450.50 - Gene3D 5.061E-3 6.996E-3 3.105E-2
2.379E-1
 1 5
33 PS50859 LONGIN PROSITE 5.061E-3 6.996E-3 3.105E-2
2.379E-1
 1 5
34 PF13774 Longin Pfam 5.061E-3 6.996E-3 3.105E-2
2.379E-1
 1 5
35 SM00234 START SMART 1.311E-2 1.760E-2
7.812E-2
6.161E-1
 1 13
36 PS50848 START PROSITE 1.511E-2 1.869E-2
8.294E-2
7.102E-1
 1 15
37 IPR002913 START lipid-bd dom InterPro 1.511E-2 1.869E-2
8.294E-2
7.102E-1
 1 15
38 PF01852 START Pfam 1.511E-2 1.869E-2
8.294E-2
7.102E-1
 1 15
39 3.30.530.20 - Gene3D 2.308E-2 2.712E-2
1.204E-1
1.000E0
 1 23
40 IPR023393 START-like dom InterPro 2.308E-2 2.712E-2
1.204E-1
1.000E0
 1 23
41 IPR011012 Longin-like dom InterPro 2.803E-2 3.213E-2
1.426E-1
1.000E0
 1 28
Show 36 more annotations

7: Pathway [Display Chart] 19 input genes in category / 101 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83057 SNARE interactions in vesicular transport BioSystems: KEGG 3.450E-44 3.485E-42 1.811E-41 3.485E-42 17 34
2 P04375 5HT3 type receptor mediated signaling pathway PantherDB 4.168E-14 2.105E-12 1.094E-11 4.210E-12 6 16
3 P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway PantherDB 8.135E-13 2.739E-11 1.423E-10 8.216E-11 7 53
4 P04379 Beta3 adrenergic receptor signaling pathway PantherDB 1.188E-12 2.999E-11 1.559E-10 1.200E-10 6 26
5 P04380 Cortocotropin releasing factor receptor signaling pathway PantherDB 3.052E-12 4.696E-11 2.441E-10 3.083E-10 6 30
6 P00039 Metabotropic glutamate receptor group III pathway PantherDB 3.248E-12 4.696E-11 2.441E-10 3.280E-10 7 64
7 P04376 5HT4 type receptor mediated signaling pathway PantherDB 3.781E-12 4.696E-11 2.441E-10 3.819E-10 6 31
8 P05915 Opioid proenkephalin pathway PantherDB 4.650E-12 4.696E-11 2.441E-10 4.696E-10 6 32
9 P05916 Opioid prodynorphin pathway PantherDB 4.650E-12 4.696E-11 2.441E-10 4.696E-10 6 32
10 P05917 Opioid proopiomelanocortin pathway PantherDB 4.650E-12 4.696E-11 2.441E-10 4.696E-10 6 32
11 P04377 Beta1 adrenergic receptor signaling pathway PantherDB 3.097E-11 2.607E-10 1.355E-9 3.128E-9 6 43
12 P04378 Beta2 adrenergic receptor signaling pathway PantherDB 3.097E-11 2.607E-10 1.355E-9 3.128E-9 6 43
13 P00040 Metabotropic glutamate receptor group II pathway PantherDB 3.583E-11 2.784E-10 1.447E-9 3.619E-9 6 44
14 P00044 Nicotinic acetylcholine receptor signaling pathway PantherDB 4.136E-11 2.984E-10 1.551E-9 4.178E-9 7 91
15 P00002 Alpha adrenergic receptor signaling pathway PantherDB 9.359E-11 6.301E-10 3.275E-9 9.452E-9 5 21
16 P05912 Dopamine receptor mediated signaling pathway PantherDB 1.026E-10 6.405E-10 3.329E-9 1.036E-8 6 52
17 1383038 Intra-Golgi and retrograde Golgi-to-ER traffic BioSystems: REACTOME 1.078E-10 6.405E-10 3.329E-9 1.089E-8 8 180
18 P04391 Oxytocin receptor mediated signaling pathway PantherDB 1.457E-10 7.745E-10 4.026E-9 1.472E-8 6 55
19 P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway PantherDB 1.457E-10 7.745E-10 4.026E-9 1.472E-8 6 55
20 P04394 Thyrotropin-releasing hormone receptor signaling pathway PantherDB 2.029E-10 1.025E-9 5.325E-9 2.049E-8 6 58
21 P04374 5HT2 type receptor mediated signaling pathway PantherDB 3.391E-10 1.631E-9 8.475E-9 3.424E-8 6 63
22 P00001 Adrenaline and noradrenaline biosynthesis PantherDB 4.490E-10 2.061E-9 1.071E-8 4.535E-8 5 28
23 P04373 5HT1 type receptor mediated signaling pathway PantherDB 4.337E-9 1.904E-8 9.897E-8 4.380E-7 5 43
24 1383040 Intra-Golgi traffic BioSystems: REACTOME 5.494E-9 2.312E-8 1.202E-7 5.549E-7 5 45
25 P00037 Ionotropic glutamate receptor pathway PantherDB 6.158E-9 2.488E-8 1.293E-7 6.219E-7 5 46
26 1383039 Retrograde transport at the Trans-Golgi-Network BioSystems: REACTOME 8.542E-9 3.318E-8 1.725E-7 8.628E-7 5 49
27 373900 Synaptic vesicle cycle BioSystems: KEGG 2.180E-6 8.154E-6 4.238E-5 2.201E-4 4 63
28 PW:0000639 insulin responsive facilitative sugar transporter mediated glucose transport pathway Pathway Ontology 2.875E-6 1.037E-5 5.391E-5 2.904E-4 3 19
29 1269881 Clathrin derived vesicle budding BioSystems: REACTOME 3.945E-6 1.328E-5 6.902E-5 3.984E-4 4 73
30 1269880 trans-Golgi Network Vesicle Budding BioSystems: REACTOME 3.945E-6 1.328E-5 6.902E-5 3.984E-4 4 73
31 1269197 ER-Phagosome pathway BioSystems: REACTOME 7.958E-6 2.593E-5 1.348E-4 8.038E-4 4 87
32 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 1.330E-5 4.199E-5 2.182E-4 1.344E-3 4 99
33 1269195 Antigen processing-Cross presentation BioSystems: REACTOME 1.556E-5 4.764E-5 2.476E-4 1.572E-3 4 103
34 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 4.784E-5 1.421E-4 7.386E-4 4.832E-3 4 137
35 1269145 Neurotoxicity of clostridium toxins BioSystems: REACTOME 9.858E-5 2.845E-4 1.478E-3 9.956E-3 2 10
36 1269896 Translocation of GLUT4 to the plasma membrane BioSystems: REACTOME 1.077E-4 3.021E-4 1.570E-3 1.087E-2 3 62
37 PW:0000713 vasopressin signaling pathway via receptor type 2 Pathway Ontology 1.704E-4 4.651E-4 2.417E-3 1.721E-2 2 13
38 SMP00246 Pirenzepine Pathway SMPDB 2.960E-4 7.001E-4 3.639E-3 2.990E-2 2 17
39 PW:0000491 vasopressin signaling Pathway Ontology 2.960E-4 7.001E-4 3.639E-3 2.990E-2 2 17
40 SMP00232 Cimetidine Pathway SMPDB 2.960E-4 7.001E-4 3.639E-3 2.990E-2 2 17
41 SMP00225 Esomeprazole Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
42 SMP00231 Famotidine Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
43 SMP00233 Nizatidine Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
44 SMP00229 Rabeprazole Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
45 SMP00227 Lansoprazole Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
46 SMP00228 Pantoprazole Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
47 SMP00230 Ranitidine Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
48 SMP00226 Omeprazole Pathway SMPDB 3.327E-4 7.001E-4 3.639E-3 3.361E-2 2 18
49 P05734 Synaptic vesicle trafficking PantherDB 5.477E-4 1.129E-3 5.867E-3
5.532E-2
 2 23
50 137981 Insulin-mediated glucose transport BioSystems: Pathway Interaction Database 8.741E-4 1.766E-3 9.177E-3
8.829E-2
 2 29
Show 45 more annotations

8: Pubmed [Display Chart] 19 input genes in category / 946 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12828989 Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. Pubmed 1.714E-23 1.622E-20 1.205E-19 1.622E-20 7 8
2 10820264 Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. Pubmed 4.406E-20 1.389E-17 1.032E-16 4.168E-17 6 7
3 11839770 Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. Pubmed 4.406E-20 1.389E-17 1.032E-16 4.168E-17 6 7
4 11278762 Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. Pubmed 5.284E-19 9.998E-17 7.428E-16 4.999E-16 6 9
5 11101518 A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. Pubmed 5.284E-19 9.998E-17 7.428E-16 4.999E-16 6 9
6 10379359 SNAREs and SNARE regulators in membrane fusion and exocytosis. Pubmed 1.321E-18 2.082E-16 1.547E-15 1.249E-15 6 10
7 9852078 Three novel proteins of the syntaxin/SNAP-25 family. Pubmed 2.905E-18 3.435E-16 2.552E-15 2.748E-15 6 11
8 12853575 A dual mechanism controlling the localization and function of exocytic v-SNAREs. Pubmed 2.905E-18 3.435E-16 2.552E-15 2.748E-15 6 11
9 18321981 Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice. Pubmed 5.808E-18 6.104E-16 4.536E-15 5.494E-15 6 12
10 18535671 VAMP8 is the v-SNARE that mediates basolateral exocytosis in a mouse model of alcoholic pancreatitis. Pubmed 1.078E-17 1.020E-15 7.579E-15 1.020E-14 6 13
11 10839363 SNAREs contribute to the specificity of membrane fusion. Pubmed 1.030E-16 8.121E-15 6.034E-14 9.745E-14 5 6
12 15363411 A role of VAMP8/endobrevin in regulated exocytosis of pancreatic acinar cells. Pubmed 1.030E-16 8.121E-15 6.034E-14 9.745E-14 5 6
13 24623722 Systematic identification of pathological lamin A interactors. Pubmed 2.155E-16 1.568E-14 1.165E-13 2.039E-13 10 337
14 19557002 Coiled-coil interactions are required for post-Golgi R-SNARE trafficking. Pubmed 3.604E-16 2.436E-14 1.810E-13 3.410E-13 5 7
15 18505797 AQP2 exocytosis in the renal collecting duct -- involvement of SNARE isoforms and the regulatory role of Munc18b. Pubmed 9.609E-16 5.347E-14 3.973E-13 9.090E-13 5 8
16 12130530 Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. Pubmed 9.609E-16 5.347E-14 3.973E-13 9.090E-13 5 8
17 26359495 The Q-soluble N-Ethylmaleimide-sensitive Factor Attachment Protein Receptor (Q-SNARE) SNAP-47 Regulates Trafficking of Selected Vesicle-associated Membrane Proteins (VAMPs). Pubmed 9.609E-16 5.347E-14 3.973E-13 9.090E-13 5 8
18 9553086 Seven novel mammalian SNARE proteins localize to distinct membrane compartments. Pubmed 2.161E-15 1.076E-13 7.996E-13 2.045E-12 5 9
19 12651853 Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis. Pubmed 2.161E-15 1.076E-13 7.996E-13 2.045E-12 5 9
20 23395379 LTP requires a unique postsynaptic SNARE fusion machinery. Pubmed 1.357E-14 6.420E-13 4.770E-12 1.284E-11 5 12
21 16677249 A critical role for vesicle-associated membrane protein-7 in exocytosis from human eosinophils and neutrophils. Pubmed 2.186E-13 9.845E-12 7.315E-11 2.068E-10 4 5
22 25419848 O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Pubmed 6.555E-13 2.480E-11 1.843E-10 6.201E-10 4 6
23 10080545 Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1. Pubmed 6.555E-13 2.480E-11 1.843E-10 6.201E-10 4 6
24 9168999 Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c. Pubmed 6.555E-13 2.480E-11 1.843E-10 6.201E-10 4 6
25 11786915 Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. Pubmed 6.555E-13 2.480E-11 1.843E-10 6.201E-10 4 6
26 8663154 Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues. Pubmed 1.529E-12 4.821E-11 3.582E-10 1.446E-9 4 7
27 21151919 Fusogenic pairings of vesicle-associated membrane proteins (VAMPs) and plasma membrane t-SNAREs--VAMP5 as the exception. Pubmed 1.529E-12 4.821E-11 3.582E-10 1.446E-9 4 7
28 12773094 A role for Sec1/Munc18 proteins in platelet exocytosis. Pubmed 1.529E-12 4.821E-11 3.582E-10 1.446E-9 4 7
29 18253931 Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells. Pubmed 1.529E-12 4.821E-11 3.582E-10 1.446E-9 4 7
30 24705552 The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion. Pubmed 1.529E-12 4.821E-11 3.582E-10 1.446E-9 4 7
31 19620288 Dual roles of the mammalian GARP complex in tethering and SNARE complex assembly at the trans-golgi network. Pubmed 5.501E-12 1.633E-10 1.213E-9 5.204E-9 4 9
32 19144319 The phagosomal proteome in interferon-gamma-activated macrophages. Pubmed 5.524E-12 1.633E-10 1.213E-9 5.226E-9 5 35
33 10469351 Syntaxin 3 and Munc-18-2 in epithelial cells during kidney development. Pubmed 9.165E-12 2.627E-10 1.952E-9 8.670E-9 4 10
34 11252894 Three ways to make a vesicle. Pubmed 1.843E-11 5.128E-10 3.810E-9 1.744E-8 5 44
35 26553929 Cargo-selective apical exocytosis in epithelial cells is conducted by Myo5B, Slp4a, Vamp7, and Syntaxin 3. Pubmed 4.363E-11 1.179E-9 8.762E-9 4.128E-8 4 14
36 17065550 Endobrevin/VAMP-8 is the primary v-SNARE for the platelet release reaction. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
37 20006577 The t-SNAREs syntaxin4 and SNAP23 but not v-SNARE VAMP2 are indispensable to tether GLUT4 vesicles at the plasma membrane in adipocyte. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
38 16339081 Syntaxins 3 and 4 are concentrated in separate clusters on the plasma membrane before the establishment of cell polarity. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
39 22144578 VAMP8 is a vesicle SNARE that regulates mucin secretion in airway goblet cells. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
40 18250339 Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
41 10713150 Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
42 19910495 VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
43 12556468 Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
44 21720706 Syntaxins 3 and 4 mediate vesicular trafficking of α5β1 and α3β1 integrins and cancer cell migration. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
45 11842301 Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
46 19274433 Increased formation of VAMP-3-containing SNARE complexes in mast cells from VAMP-8 deficient cells. appetite. Pubmed 1.044E-10 2.146E-9 1.595E-8 9.873E-8 3 3
47 14668490 Mammalian late vacuole protein sorting orthologues participate in early endosomal fusion and interact with the cytoskeleton. Pubmed 1.332E-10 2.625E-9 1.951E-8 1.260E-7 4 18
48 19546860 The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth. Pubmed 1.332E-10 2.625E-9 1.951E-8 1.260E-7 4 18
49 17255364 Characterization of immunoisolated human gastric parietal cells tubulovesicles: identification of regulators of apical recycling. Pubmed 2.709E-10 5.230E-9 3.886E-8 2.563E-7 5 74
50 23677696 VAMP4 is required to maintain the ribbon structure of the Golgi apparatus. Pubmed 4.173E-10 6.368E-9 4.731E-8 3.948E-7 3 4
Show 45 more annotations

9: Interaction [Display Chart] 19 input genes in category / 556 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:STX7 STX7 interactions 2.052E-34 1.141E-31 7.871E-31 1.141E-31 16 98
2 int:STX12 STX12 interactions 2.834E-31 7.726E-29 5.330E-28 1.576E-28 15 101
3 int:STX6 STX6 interactions 4.169E-31 7.726E-29 5.330E-28 2.318E-28 14 68
4 int:VAMP8 VAMP8 interactions 4.694E-29 6.524E-27 4.501E-26 2.610E-26 12 37
5 int:STX3 STX3 interactions 3.842E-28 4.272E-26 2.947E-25 2.136E-25 13 69
6 int:VAMP4 VAMP4 interactions 1.758E-27 1.629E-25 1.124E-24 9.775E-25 12 48
7 int:STX4 STX4 interactions 2.186E-27 1.736E-25 1.198E-24 1.215E-24 13 78
8 int:VAMP3 VAMP3 interactions 1.824E-25 1.268E-23 8.747E-23 1.014E-22 12 68
9 int:SNAP23 SNAP23 interactions 3.843E-25 2.374E-23 1.638E-22 2.137E-22 12 72
10 int:NAPA NAPA interactions 1.024E-23 5.691E-22 3.926E-21 5.691E-21 11 57
11 int:STX8 STX8 interactions 3.875E-21 1.959E-19 1.351E-18 2.154E-18 10 56
12 int:NAPB NAPB interactions 3.959E-20 1.835E-18 1.266E-17 2.201E-17 8 20
13 int:STX18 STX18 interactions 8.624E-20 3.689E-18 2.545E-17 4.795E-17 9 42
14 int:STX5 STX5 interactions 1.182E-19 4.695E-18 3.239E-17 6.573E-17 10 77
15 int:STXBP5 STXBP5 interactions 7.978E-19 2.957E-17 2.040E-16 4.436E-16 7 13
16 int:VAMP2 VAMP2 interactions 1.495E-18 5.194E-17 3.583E-16 8.311E-16 10 98
17 int:VTI1A VTI1A interactions 1.595E-18 5.216E-17 3.598E-16 8.867E-16 7 14
18 int:STX11 STX11 interactions 3.734E-18 1.153E-16 7.958E-16 2.076E-15 10 107
19 int:STXBP6 STXBP6 interactions 5.309E-18 1.554E-16 1.072E-15 2.952E-15 7 16
20 int:VTI1B VTI1B interactions 1.479E-16 4.110E-15 2.836E-14 8.221E-14 9 91
21 int:VAMP7 VAMP7 interactions 1.599E-16 4.233E-15 2.920E-14 8.889E-14 7 24
22 int:CLEC12A CLEC12A interactions 5.456E-16 1.379E-14 9.513E-14 3.034E-13 7 28
23 int:SNAP29 SNAP29 interactions 4.103E-15 9.918E-14 6.843E-13 2.281E-12 8 73
24 int:TMEM17 TMEM17 interactions 4.517E-14 1.043E-12 7.199E-12 2.511E-11 11 401
25 int:STX10 STX10 interactions 4.692E-14 1.043E-12 7.199E-12 2.609E-11 6 22
26 int:NSF NSF interactions 5.596E-14 1.197E-12 8.255E-12 3.111E-11 8 100
27 int:SNAP25 SNAP25 interactions 3.138E-13 6.463E-12 4.459E-11 1.745E-10 7 65
28 int:TMEM216 TMEM216 interactions 1.317E-12 2.615E-11 1.804E-10 7.322E-10 9 245
29 int:GOSR1 GOSR1 interactions 3.257E-12 6.245E-11 4.308E-10 1.811E-9 6 42
30 int:STX2 STX2 interactions 1.617E-11 2.996E-10 2.067E-9 8.989E-9 5 21
31 int:SEC22B SEC22B interactions 1.692E-11 3.035E-10 2.093E-9 9.407E-9 7 113
32 int:STX16 STX16 interactions 2.670E-11 4.639E-10 3.200E-9 1.485E-8 5 23
33 int:GOSR2 GOSR2 interactions 6.389E-11 1.076E-9 7.426E-9 3.552E-8 5 27
34 int:NAPG NAPG interactions 1.588E-10 2.598E-9 1.792E-8 8.832E-8 5 32
35 int:STXBP2 STXBP2 interactions 2.192E-10 3.482E-9 2.402E-8 1.219E-7 5 34
36 int:VAMP1 VAMP1 interactions 6.733E-10 1.040E-8 7.174E-8 3.744E-7 4 13
37 int:STX1B STX1B interactions 9.420E-10 1.416E-8 9.766E-8 5.237E-7 4 14
38 int:NBAS NBAS interactions 2.872E-9 4.202E-8 2.899E-7 1.597E-6 4 18
39 int:SCFD1 SCFD1 interactions 3.249E-9 4.631E-8 3.195E-7 1.806E-6 5 57
40 int:STX19 STX19 interactions 5.605E-9 7.792E-8 5.375E-7 3.117E-6 4 21
41 int:VPS18 VPS18 interactions 6.893E-9 9.347E-8 6.449E-7 3.832E-6 5 66
42 int:STXBP1 STXBP1 interactions 1.153E-8 1.527E-7 1.053E-6 6.411E-6 5 73
43 int:STX1A STX1A interactions 1.416E-8 1.830E-7 1.263E-6 7.870E-6 5 76
44 int:BET1 BET1 interactions 1.909E-8 2.412E-7 1.664E-6 1.061E-5 4 28
45 int:AQP2 AQP2 interactions 2.212E-8 2.734E-7 1.886E-6 1.230E-5 4 29
46 int:ATP4A ATP4A interactions 3.528E-8 4.264E-7 2.942E-6 1.962E-5 5 91
47 int:STXBP3 STXBP3 interactions 6.834E-8 7.916E-7 5.461E-6 3.800E-5 4 38
48 int:VPS45 VPS45 interactions 6.834E-8 7.916E-7 5.461E-6 3.800E-5 4 38
49 int:SYPL1 SYPL1 interactions 8.768E-8 9.949E-7 6.864E-6 4.875E-5 3 9
50 int:VAMP5 VAMP5 interactions 1.252E-7 1.392E-6 9.603E-6 6.960E-5 3 10
Show 45 more annotations

10: Cytoband [Display Chart] 19 input genes in category / 18 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2p12-p11.2 2p12-p11.2 2.191E-3 2.949E-2
1.031E-1
 3.944E-2 1 4
2 1q24-q25 1q24-q25 3.285E-3 2.949E-2
1.031E-1
5.913E-2
 1 6
3 16p11.2 16p11.2 5.466E-3 2.949E-2
1.031E-1
9.839E-2
 2 203
4 7p15.1 7p15.1 7.104E-3 2.949E-2
1.031E-1
1.279E-1
 1 13
5 1p36.23 1p36.23 8.193E-3 2.949E-2
1.031E-1
1.475E-1
 1 15
6 10q25.2 10q25.2 1.037E-2 3.110E-2
1.087E-1
1.866E-1
 1 19
7 1q25.3 1q25.3 1.686E-2 3.376E-2
1.180E-1
3.035E-1
 1 31
8 1p35.3 1p35.3 1.848E-2 3.376E-2
1.180E-1
3.326E-1
 1 34
9 5q13.3 5q13.3 1.902E-2 3.376E-2
1.180E-1
3.423E-1
 1 35
10 14q24.1 14q24.1 2.009E-2 3.376E-2
1.180E-1
3.617E-1
 1 37
11 11q12.3 11q12.3 2.063E-2 3.376E-2
1.180E-1
3.714E-1
 1 38
12 17p12 17p12 2.760E-2 3.685E-2
1.288E-1
4.967E-1
 1 51
13 15q14 15q14 2.813E-2 3.685E-2
1.288E-1
5.063E-1
 1 52
14 12q24.33 12q24.33 2.866E-2 3.685E-2
1.288E-1
5.159E-1
 1 53
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 13 input genes in category / 117 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 19 input genes in category / 5 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 818 Syntaxins genenames.org 1.753E-24 8.765E-24 2.001E-23 8.765E-24 9 16
2 1124 SNAREs genenames.org 2.090E-12 5.224E-12 1.193E-11 1.045E-11 5 15
3 12 Vesicle associated membrane proteins genenames.org 2.966E-11 4.944E-11 1.129E-10 1.483E-10 4 7
4 759 StAR related lipid transfer domain containing genenames.org 1.556E-2 1.945E-2 4.440E-2
7.778E-2
 1 15

13: Coexpression [Display Chart] 19 input genes in category / 1588 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M5910 Genes involved in protein secretion pathway. MSigDB H: Hallmark Gene Sets (v6.0) 1.229E-8 1.952E-5 1.551E-4 1.952E-5 5 96
2 18811983-Table2 Human Lung Stav08 198genes GeneSigDB 4.771E-6 3.788E-3 3.011E-2 7.576E-3 4 141
3 M5606 Genes down-regulated in comparison of untreated CD4 [GeneID=920] T cells versus those treated with TGFB1 [GeneID=7040] and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 1.897E-5 6.025E-3 4.788E-2 3.012E-2 4 200
4 M9658 Genes up-regulated in CD4 [GeneID=920] T helper cells Th0: 1h versus 10h. MSigDB C7: Immunologic Signatures (v6.0) 1.897E-5 6.025E-3 4.788E-2 3.012E-2 4 200
5 M4480 Genes down-regulated in comparison of naive CD4 [GeneID=920] CD8 T cells versus monocytes cultured for 0 days. MSigDB C7: Immunologic Signatures (v6.0) 1.897E-5 6.025E-3 4.788E-2 3.012E-2 4 200
6 M2867 Genes up-regulated in epithelial lung cancer cell lines upon over-expression of an oncogenic form of KRAS [Gene ID=3845] gene and knockdown of TBK1 [Gene ID=29110] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 8.077E-5 2.138E-2
1.699E-1
1.283E-1
 4 290
7 18547747-Table1 Human Leukemia Mollinedo08 117genes GeneSigDB 1.151E-4 2.611E-2
2.075E-1
1.828E-1
 3 117
8 M19541 Genes commonly down-regulated in human alveolar rhabdomyosarcoma (ARMS) and its mouse model overexpressing PAX3-FOXO1 [GeneID=5077;2308] fusion. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.994E-4 2.679E-2
2.129E-1
4.754E-1
 4 408
9 M7449 Genes up-regulated in CD4 [GeneID=920] T cells with STAT3 [GeneID=6774] knockout: IL6 [GeneID=3569] versus TGF beta and IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.679E-2
2.129E-1
8.712E-1
 3 199
10 M5170 Genes up-regulated in comparison of macrophages versus macrophages exposed to M. tuberculosis. MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.679E-2
2.129E-1
8.712E-1
 3 199
11 M6130 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL-12 (2h) versus untreated (2h). MSigDB C7: Immunologic Signatures (v6.0) 5.486E-4 2.679E-2
2.129E-1
8.712E-1
 3 199
12 M9418 Genes down-regulated after poly(IC) injection: CD8A [GeneID=925] dendritic cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
13 M4795 Genes down-regulated in comparison of lineage negative versus neutrophils. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
14 M7192 Genes up-regulated in transitional B lymphocytes from cord blood: CR2 [GeneID=1380] low versus CR2 [GeneID=1380] high. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
15 M8079 Genes down-regulated in lymph node CD4 [GeneID=920] T cells: scurfy (non-functional form of FOXP3 [GeneID=50943]) versus scurfy and IL2 [GeneID=3558] knockout. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
16 M5997 Genes up-regulated in macrophages treated by IL6 [GeneID=3569]: 100min versus 400min. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
17 M3156 Genes up-regulated in comparison of T follicular helper (Tfh) cells versus Th17 cells. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
18 M9045 Genes up-regulated in T reg: untreated versus ZM 241385 [PubChem=176407]. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
19 M4744 Genes down-regulated in comparison of LSK versus B cells. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
20 M7303 Genes down-regulated in T reg cells (2h): medium versus TNF [GeneID=7124]. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
21 M7240 Genes down-regulated in cortical thymocytes versus thymus whole cortex. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
22 M4111 Genes down-regulated in comparison of dendritic cells (DC) stimulated with Pam3Csk4 (TLR1/2 agonist) at 0.5 h versus those stimulated at 8 h. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
23 M5099 Genes down-regulated in comparison of untreated CD8+ dendritic cells (DC) at 4 h versus those treated with IFNG [GeneID=3458] at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
24 M6019 Genes up-regulated in CD4 [GeneID=920] T cells: untreated (0h) versus activated by anti-CD3 and anti-CD28 and then stimulated by TGFB1 and IL4 [GeneID=7040;3565] (6h). MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
25 M3840 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
26 M6005 Genes up-regulated in macrophages with SOCS3 [GeneID=9021] knockout treated by IL6 [GeneID=3569]: 100min versus 400min. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
27 M3925 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
28 M4424 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulated NK cells. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
29 M7162 Genes down-regulated in CD4 [GeneID=920] T cells treated with HDAC inhibitors: 2h versus 12h. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
30 M5097 Genes up-regulated in comparison of untreated CD8+ dendritic cells (DC) at 4 h versus those treated with IFNG [GeneID=3458] at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
31 M4496 Genes down-regulated in comparison of naive CD8 T cells versus day 0 monocytes. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
32 M4503 Genes down-regulated in comparison of naive CD4 [GeneID=920] T cells versus unstimulatd dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
33 M5117 Genes up-regulated in comparison of CD8 dendritic cells (DC) versus CD4- [GeneID=920] CD8- DCs. MSigDB C7: Immunologic Signatures (v6.0) 5.567E-4 2.679E-2
2.129E-1
8.840E-1
 3 200
34 16778177-Table3 Human Brain Wang06 79genes GeneSigDB 7.046E-4 3.291E-2
2.616E-1
1.000E0
 2 48
35 M1415 Genes whose expression in bone marrow samples correlated directly with increased levels of serum IL5 [GeneID=3567]. MSigDB C2: CGP Curated Gene Sets (v6.0) 7.953E-4 3.608E-2
2.868E-1
1.000E0
 2 51
36 M7300 Selected genes up-regulated in response to the Ras inhibitor salirasib [PubChem=5469318] in a panel of cancer cell lines with constantly active HRAS [GeneID=3265]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.003E-3 4.405E-2
3.501E-1
1.000E0
 3 245
37 19074878-SuppTable1 Human Leukemia Hillion08 1176genes GeneSigDB 1.026E-3 4.405E-2
3.501E-1
1.000E0
 3 247
Show 32 more annotations

14: Coexpression Atlas [Display Chart] 19 input genes in category / 932 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 14 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 19 input genes in category / 723 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1:PITA hsa-miR-1:PITA TOP PITA 2.496E-6 6.080E-4 4.354E-3 1.805E-3 4 371
2 hsa-miR-206:PITA hsa-miR-206:PITA TOP PITA 2.496E-6 6.080E-4 4.354E-3 1.805E-3 4 371
3 hsa-miR-613:PITA hsa-miR-613:PITA TOP PITA 2.523E-6 6.080E-4 4.354E-3 1.824E-3 4 372
4 hsa-miR-206:Functional MTI Functional MTI miRTarbase 4.464E-6 8.069E-4 5.778E-3 3.228E-3 3 122
5 hsa-miR-24:PITA hsa-miR-24:PITA TOP PITA 2.711E-5 3.920E-3 2.808E-2 1.960E-2 3 223
6 hsa-miR-7114-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.959E-5 7.457E-3
5.340E-2
6.477E-2
 2 53
7 hsa-miR-1180-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.959E-5 7.457E-3
5.340E-2
6.477E-2
 2 53
8 hsa-miR-519b-3p:Functional MTI Functional MTI miRTarbase 9.801E-5 7.457E-3
5.340E-2
7.086E-2
 3 344
9 hsa-miR-519a-3p:Functional MTI Functional MTI miRTarbase 1.023E-4 7.457E-3
5.340E-2
7.394E-2
 3 349
10 hsa-miR-519c-3p:Functional MTI Functional MTI miRTarbase 1.031E-4 7.457E-3
5.340E-2
7.457E-2
 3 350
11 hsa-miR-660-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.274E-4 8.374E-3
5.997E-2
9.211E-2
 3 376
12 hsa-miR-3189-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.703E-4 9.607E-3
6.880E-2
1.231E-1
 2 73
13 hsa-miR-4763-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.750E-4 9.607E-3
6.880E-2
1.265E-1
 2 74
14 hsa-miR-555:mirSVR highEffct hsa-miR-555:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.174E-4 9.607E-3
6.880E-2
1.572E-1
 3 451
15 hsa-miR-6891-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.309E-4 9.607E-3
6.880E-2
1.670E-1
 2 85
16 hsa-miR-1915*:mirSVR highEffct hsa-miR-1915*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.319E-4 9.607E-3
6.880E-2
1.676E-1
 3 461
17 hsa-miR-613:Functional MTI Functional MTI miRTarbase 2.419E-4 9.607E-3
6.880E-2
1.749E-1
 2 87
18 hsa-miR-148a:PITA hsa-miR-148a:PITA TOP PITA 2.658E-4 9.607E-3
6.880E-2
1.921E-1
 3 483
19 hsa-miR-152:PITA hsa-miR-152:PITA TOP PITA 2.658E-4 9.607E-3
6.880E-2
1.921E-1
 3 483
20 hsa-miR-148b:PITA hsa-miR-148b:PITA TOP PITA 2.658E-4 9.607E-3
6.880E-2
1.921E-1
 3 483
21 hsa-miR-938:PITA hsa-miR-938:PITA TOP PITA 3.068E-4 1.056E-2
7.565E-2
2.218E-1
 2 98
22 hsa-miR-2682-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.863E-4 1.228E-2
8.792E-2
2.793E-1
 2 110
23 hsa-miR-125b-2-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.004E-4 1.228E-2
8.792E-2
2.895E-1
 2 112
24 hsa-miR-449c-5p:Functional MTI Functional MTI miRTarbase 4.075E-4 1.228E-2
8.792E-2
2.947E-1
 2 113
25 hsa-miR-34b-5p:Functional MTI Functional MTI miRTarbase 4.825E-4 1.363E-2
9.764E-2
3.488E-1
 2 123
26 ACACTAC,MIR-142-3P:MSigDB ACACTAC,MIR-142-3P:MSigDB MSigDB 4.903E-4 1.363E-2
9.764E-2
3.545E-1
 2 124
27 hsa-miR-204-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.468E-4 1.455E-2
1.042E-1
3.954E-1
 2 131
28 hsa-miR-4646-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.636E-4 1.455E-2
1.042E-1
4.075E-1
 2 133
29 hsa-miR-484:PITA hsa-miR-484:PITA TOP PITA 7.539E-4 1.879E-2
1.346E-1
5.450E-1
 2 154
30 hsa-miR-1200:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.233E-4 1.944E-2
1.392E-1
5.952E-1
 2 161
31 hsa-miR-6818-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.335E-4 1.944E-2
1.392E-1
6.026E-1
 2 162
32 hsa-miR-657:PITA hsa-miR-657:PITA TOP PITA 9.711E-4 2.176E-2
1.558E-1
7.021E-1
 2 175
33 hsa-miR-4643:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.931E-4 2.176E-2
1.558E-1
7.180E-1
 2 177
34 hsa-miR-142-3p:PITA hsa-miR-142-3p:PITA TOP PITA 1.252E-3 2.612E-2
1.870E-1
9.051E-1
 2 199
35 hsa-miR-150:PITA hsa-miR-150:PITA TOP PITA 1.264E-3 2.612E-2
1.870E-1
9.141E-1
 2 200
36 ACTGCCT,MIR-34B:MSigDB ACTGCCT,MIR-34B:MSigDB MSigDB 1.327E-3 2.619E-2
1.875E-1
9.597E-1
 2 205
37 hsa-miR-202-3p:Functional MTI Functional MTI miRTarbase 1.340E-3 2.619E-2
1.875E-1
9.690E-1
 2 206
38 hsa-miR-576-3p:PITA hsa-miR-576-3p:PITA TOP PITA 1.445E-3 2.684E-2
1.922E-1
1.000E0
 2 214
39 hsa-miR-338-3p:PITA hsa-miR-338-3p:PITA TOP PITA 1.485E-3 2.684E-2
1.922E-1
1.000E0
 2 217
40 hsa-miR-6500-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.485E-3 2.684E-2
1.922E-1
1.000E0
 2 217
41 hsa-miR-3714:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.567E-3 2.763E-2
1.979E-1
1.000E0
 2 223
42 hsa-miR-5690:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.623E-3 2.793E-2
2.000E-1
1.000E0
 2 227
43 hsa-miR-548b-3p:PITA hsa-miR-548b-3p:PITA TOP PITA 1.665E-3 2.800E-2
2.005E-1
1.000E0
 2 230
44 hsa-miR-569:PITA hsa-miR-569:PITA TOP PITA 1.840E-3 2.916E-2
2.088E-1
1.000E0
 2 242
45 hsa-miR-133a:PITA hsa-miR-133a:PITA TOP PITA 1.855E-3 2.916E-2
2.088E-1
1.000E0
 2 243
46 hsa-miR-133b:PITA hsa-miR-133b:PITA TOP PITA 1.855E-3 2.916E-2
2.088E-1
1.000E0
 2 243
47 hsa-miR-517c:mirSVR highEffct hsa-miR-517c:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.103E-3 3.235E-2
2.317E-1
1.000E0
 2 259
48 GGATCCG,MIR-127:MSigDB GGATCCG,MIR-127:MSigDB MSigDB 2.365E-3 3.443E-2
2.466E-1
1.000E0
 1 9
49 hsa-miR-382:PITA hsa-miR-382:PITA TOP PITA 2.382E-3 3.443E-2
2.466E-1
1.000E0
 2 276
50 hsa-miR-940:PITA hsa-miR-940:PITA TOP PITA 2.416E-3 3.443E-2
2.466E-1
1.000E0
 2 278
Show 45 more annotations

17: Drug [Display Chart] 19 input genes in category / 4358 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID006433111 Teglicar [inn] Stitch 6.466E-14 2.818E-10 2.524E-9 2.818E-10 6 29
2 CID000010935 maleimide Stitch 8.260E-12 1.800E-8 1.612E-7 3.600E-8 7 131
3 CID000005330 sulfamethoxypyridazine Stitch 7.178E-11 1.043E-7 9.340E-7 3.128E-7 5 35
4 CID001008511 1,4-bis-(phenoxyacetyl)piperazine Stitch 3.853E-10 4.198E-7 3.760E-6 1.679E-6 7 226
5 CID006857352 AC1OAGFW Stitch 6.470E-9 5.639E-6 5.051E-5 2.820E-5 6 185
6 CID000398799 TC-6 Stitch 2.761E-8 2.005E-5 1.796E-4 1.203E-4 4 39
7 CID000001855 DHBT Stitch 4.035E-8 2.512E-5 2.250E-4 1.758E-4 5 120
8 CID000002287 NSC381866 Stitch 2.301E-7 1.253E-4 1.123E-3 1.003E-3 5 170
9 1596 UP Desipramine hydrochloride [58-28-6]; Up 200; 13.2uM; HL60; HG-U133A Broad Institute CMAP Up 5.026E-7 2.434E-4 2.180E-3 2.190E-3 5 199
10 CID000326807 NSC298883 Stitch 7.982E-7 3.458E-4 3.097E-3 3.479E-3 4 89
11 CID002733635 Fm 4-64 Stitch 8.728E-7 3.458E-4 3.097E-3 3.804E-3 4 91
12 CID000003800 NSC613009 Stitch 3.747E-6 1.317E-3 1.180E-2 1.633E-2 4 131
13 ctd:C096325 botulinum toxin type D CTD 3.929E-6 1.317E-3 1.180E-2 1.712E-2 2 4
14 ctd:C096323 rimabotulinumtoxinB CTD 6.546E-6 2.038E-3 1.825E-2 2.853E-2 2 5
15 ctd:D006220 Haloperidol CTD 7.357E-6 2.137E-3 1.915E-2 3.206E-2 5 344
16 CID000643964 PtdIns(3)P Stitch 1.180E-5 3.213E-3 2.878E-2
5.141E-2
 4 175
17 1334 UP Myricetin [529-44-2]; Up 200; 12.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 1.500E-5 3.422E-3 3.065E-2
6.536E-2
 4 186
18 CID005287758 AC1NRA8N Stitch 1.631E-5 3.422E-3 3.065E-2
7.106E-2
 4 190
19 970 DN 5230742; Down 200; 17uM; MCF7; HT HG-U133A EA Broad Institute CMAP Down 1.699E-5 3.422E-3 3.065E-2
7.405E-2
 4 192
20 4713 UP 0175029-0000 [211245-78-2]; Up 200; 10uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.770E-5 3.422E-3 3.065E-2
7.712E-2
 4 194
21 2650 DN Androsterone [53-41-8]; Down 200; 13.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.770E-5 3.422E-3 3.065E-2
7.712E-2
 4 194
22 5092 DN Rimexolone [49697-38-3]; Down 200; 10.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 1.806E-5 3.422E-3 3.065E-2
7.870E-2
 4 195
23 1303 DN Arecoline hydrobromide [300-08-3]; Down 200; 17uM; HL60; HT HG-U133A Broad Institute CMAP Down 1.806E-5 3.422E-3 3.065E-2
7.870E-2
 4 195
24 6246 DN Saquinavir mesylate [149845-06-7]; Down 200; 5.2uM; MCF7; HT HG-U133A Broad Institute CMAP Down 1.917E-5 3.477E-3 3.114E-2
8.356E-2
 4 198
25 5465 UP Pivampicillin [33817-20-8]; Up 200; 8.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 1.995E-5 3.477E-3 3.114E-2
8.692E-2
 4 200
26 CID000004597 o-nitrophenyl beta-D-fucopyranoside Stitch 3.173E-5 5.318E-3 4.763E-2
1.383E-1
 3 75
27 CID000068916 epiroprim Stitch 4.305E-5 6.949E-3
6.224E-2
1.876E-1
 2 12
28 CID000004598 NSC-114340 Stitch 7.812E-5 1.216E-2
1.089E-1
3.405E-1
 2 16
29 ctd:C551172 bis-N,N-dimethylamino-2-(N-methylpyrrolyl)methyl cyclopentadienyl titanium (IV) CTD 8.427E-5 1.266E-2
1.134E-1
3.672E-1
 3 104
30 ctd:C523184 mocetinostat CTD 8.918E-5 1.295E-2
1.160E-1
3.886E-1
 3 106
31 CID006857696 62--a Stitch 9.951E-5 1.369E-2
1.227E-1
4.337E-1
 2 18
32 ctd:C005219 methyl cellosolve CTD 1.005E-4 1.369E-2
1.227E-1
4.382E-1
 4 303
33 ctd:D009536 Niacinamide CTD 1.196E-4 1.579E-2
1.414E-1
5.210E-1
 3 117
34 CID000004551 28 N Stitch 1.790E-4 2.228E-2
1.996E-1
7.800E-1
 2 24
35 CID000066435 estradiol phosphate Stitch 1.790E-4 2.228E-2
1.996E-1
7.800E-1
 2 24
36 CID005485225 batrachotoxinin A 20-alpha-benzoate Stitch 1.944E-4 2.289E-2
2.051E-1
8.474E-1
 2 25
37 CID000020667 dodecyl ether Stitch 2.105E-4 2.289E-2
2.051E-1
9.175E-1
 2 26
38 CID000004246 AC1L1HQG Stitch 2.119E-4 2.289E-2
2.051E-1
9.235E-1
 3 142
39 CID000078798 octaethylene glycol Stitch 2.626E-4 2.289E-2
2.051E-1
1.000E0
 2 29
40 ctd:D003024 Clozapine CTD 2.700E-4 2.289E-2
2.051E-1
1.000E0
 4 392
41 CID000003724 iodixanol Stitch 2.812E-4 2.289E-2
2.051E-1
1.000E0
 2 30
42 CID000123968 AC1L3XN4 Stitch 3.620E-4 2.289E-2
2.051E-1
1.000E0
 2 34
43 CID004369084 PNU-107859 Stitch 3.849E-4 2.289E-2
2.051E-1
1.000E0
 3 174
44 1280 UP Ritodrine hydrochloride [23239-51-2]; Up 200; 12.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.389E-4 2.289E-2
2.051E-1
1.000E0
 3 182
45 1344 DN Adamantamine fumarate [80789-67-9]; Down 200; 9.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 4.532E-4 2.289E-2
2.051E-1
1.000E0
 3 184
46 CID000002532 AC1L1DW2 Stitch 4.677E-4 2.289E-2
2.051E-1
1.000E0
 3 186
47 1299 UP Estradiol-17 beta [50-28-2]; Up 200; 14.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 4.825E-4 2.289E-2
2.051E-1
1.000E0
 3 188
48 2805 DN Harmaline hydrochloride dihydrate [6027-98-1]; Down 200; 14uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.825E-4 2.289E-2
2.051E-1
1.000E0
 3 188
49 4121 DN Ginkgolide A [15291-75-5]; Down 200; 9.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.901E-4 2.289E-2
2.051E-1
1.000E0
 3 189
50 7439 DN Disopyramide [3737-09-5]; Down 200; 11.8uM; MCF7; HT HG-U133A Broad Institute CMAP Down 4.977E-4 2.289E-2
2.051E-1
1.000E0
 3 190
Show 45 more annotations

18: Disease [Display Chart] 18 input genes in category / 142 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1836033 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome DisGeNET Curated 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
2 cv:CN224991 Generalized epilepsy with febrile seizures plus, type 9 Clinical Variations 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
3 OMIN:609528 CEREBRAL DYSGENESIS, NEUROPATHY, ICHTHYOSIS, AND PALMOPLANTAR KERATODERMA SYNDROME OMIM 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
4 C4015395 GENERALIZED EPILEPSY WITH FEBRILE SEIZURES PLUS, TYPE 9 DisGeNET Curated 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
5 cv:C1836033 Cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma syndrome Clinical Variations 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
6 C0456144 Cerebral dysgenesis DisGeNET BeFree 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
7 C4225156 MENTAL RETARDATION, AUTOSOMAL DOMINANT 34 DisGeNET Curated 1.111E-3 2.253E-2
1.248E-1
1.577E-1
 1 1
8 C0302810 Uremia syndrome DisGeNET BeFree 2.220E-3 3.941E-2
2.182E-1
3.153E-1
 1 2
Show 3 more annotations