Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc176_7, positive side

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1: GO: Molecular Function [Display Chart] 7 input genes in category / 24 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0070491 repressing transcription factor binding 2.113E-4 5.071E-3 1.915E-2 5.071E-3 2 60
2 GO:0042826 histone deacetylase binding 7.615E-4 9.138E-3 3.450E-2 1.828E-2 2 114
3 GO:0001047 core promoter binding 1.566E-3 1.253E-2 4.731E-2 3.759E-2 2 164
4 GO:0001223 transcription coactivator binding 4.867E-3 2.920E-2
1.103E-1
1.168E-1
 1 13
5 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 7.192E-3 3.003E-2
1.134E-1
1.726E-1
 2 357
6 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 7.508E-3 3.003E-2
1.134E-1
1.802E-1
 2 365
7 GO:0043425 bHLH transcription factor binding 1.120E-2 3.360E-2
1.269E-1
2.688E-1
 1 30
8 GO:0001221 transcription cofactor binding 1.120E-2 3.360E-2
1.269E-1
2.688E-1
 1 30
9 GO:0051721 protein phosphatase 2A binding 1.306E-2 3.482E-2
1.315E-1
3.134E-1
 1 35
Show 4 more annotations

2: GO: Biological Process [Display Chart] 7 input genes in category / 299 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0048469 cell maturation 2.639E-7 7.892E-5 4.955E-4 7.892E-5 4 176
2 GO:0021700 developmental maturation 1.572E-6 2.351E-4 1.476E-3 4.702E-4 4 275
3 GO:0002062 chondrocyte differentiation 5.997E-6 4.698E-4 2.950E-3 1.793E-3 3 105
4 GO:0001503 ossification 7.253E-6 4.698E-4 2.950E-3 2.169E-3 4 404
5 GO:0048935 peripheral nervous system neuron development 9.428E-6 4.698E-4 2.950E-3 2.819E-3 2 13
6 GO:0048934 peripheral nervous system neuron differentiation 9.428E-6 4.698E-4 2.950E-3 2.819E-3 2 13
7 GO:0060216 definitive hemopoiesis 3.618E-5 1.478E-3 9.282E-3 1.082E-2 2 25
8 GO:0051216 cartilage development 3.955E-5 1.478E-3 9.282E-3 1.182E-2 3 197
9 GO:0031069 hair follicle morphogenesis 5.602E-5 1.861E-3 1.169E-2 1.675E-2 2 31
10 GO:0048730 epidermis morphogenesis 7.583E-5 2.267E-3 1.424E-2 2.267E-2 2 36
11 GO:0061448 connective tissue development 9.666E-5 2.627E-3 1.650E-2 2.890E-2 3 266
12 GO:0045599 negative regulation of fat cell differentiation 1.412E-4 3.519E-3 2.210E-2 4.223E-2 2 49
13 GO:0007422 peripheral nervous system development 3.774E-4 8.680E-3
5.450E-2
1.128E-1
 2 80
14 GO:0042475 odontogenesis of dentin-containing tooth 4.988E-4 9.981E-3
6.267E-2
1.492E-1
 2 92
15 GO:0022405 hair cycle process 5.774E-4 9.981E-3
6.267E-2
1.726E-1
 2 99
16 GO:0022404 molting cycle process 5.774E-4 9.981E-3
6.267E-2
1.726E-1
 2 99
17 GO:0001942 hair follicle development 5.774E-4 9.981E-3
6.267E-2
1.726E-1
 2 99
18 GO:0098773 skin epidermis development 6.008E-4 9.981E-3
6.267E-2
1.797E-1
 2 101
19 GO:2000872 positive regulation of progesterone secretion 7.516E-4 1.183E-2
7.427E-2
2.247E-1
 1 2
20 GO:0042303 molting cycle 8.466E-4 1.189E-2
7.466E-2
2.531E-1
 2 120
21 GO:0042633 hair cycle 8.466E-4 1.189E-2
7.466E-2
2.531E-1
 2 120
22 GO:0045598 regulation of fat cell differentiation 8.749E-4 1.189E-2
7.466E-2
2.616E-1
 2 122
23 GO:0032609 interferon-gamma production 9.181E-4 1.194E-2
7.495E-2
2.745E-1
 2 125
24 GO:0042476 odontogenesis 9.774E-4 1.218E-2
7.646E-2
2.922E-1
 2 129
25 GO:2000870 regulation of progesterone secretion 1.127E-3 1.296E-2
8.140E-2
3.371E-1
 1 3
26 GO:0071336 regulation of hair follicle cell proliferation 1.127E-3 1.296E-2
8.140E-2
3.371E-1
 1 3
27 GO:0071335 hair follicle cell proliferation 1.503E-3 1.549E-2
9.729E-2
4.493E-1
 1 4
28 GO:1902617 response to fluoride 1.503E-3 1.549E-2
9.729E-2
4.493E-1
 1 4
29 GO:2000196 positive regulation of female gonad development 1.503E-3 1.549E-2
9.729E-2
4.493E-1
 1 4
30 GO:0042701 progesterone secretion 1.878E-3 1.812E-2
1.138E-1
5.616E-1
 1 5
31 GO:0002051 osteoblast fate commitment 1.878E-3 1.812E-2
1.138E-1
5.616E-1
 1 5
32 GO:0036295 cellular response to increased oxygen levels 2.629E-3 2.296E-2
1.442E-1
7.860E-1
 1 7
33 GO:0071455 cellular response to hyperoxia 2.629E-3 2.296E-2
1.442E-1
7.860E-1
 1 7
34 GO:0001649 osteoblast differentiation 2.881E-3 2.296E-2
1.442E-1
8.615E-1
 2 223
35 GO:0045444 fat cell differentiation 2.932E-3 2.296E-2
1.442E-1
8.767E-1
 2 225
36 GO:0035947 regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter 3.004E-3 2.296E-2
1.442E-1
8.981E-1
 1 8
37 GO:1903431 positive regulation of cell maturation 3.004E-3 2.296E-2
1.442E-1
8.981E-1
 1 8
38 GO:0002318 myeloid progenitor cell differentiation 3.004E-3 2.296E-2
1.442E-1
8.981E-1
 1 8
39 GO:0071559 response to transforming growth factor beta 3.140E-3 2.296E-2
1.442E-1
9.390E-1
 2 233
40 GO:0002870 T cell anergy 3.379E-3 2.296E-2
1.442E-1
1.000E0
 1 9
41 GO:0002249 lymphocyte anergy 3.379E-3 2.296E-2
1.442E-1
1.000E0
 1 9
42 GO:0002667 regulation of T cell anergy 3.379E-3 2.296E-2
1.442E-1
1.000E0
 1 9
43 GO:0070417 cellular response to cold 3.379E-3 2.296E-2
1.442E-1
1.000E0
 1 9
44 GO:0002911 regulation of lymphocyte anergy 3.379E-3 2.296E-2
1.442E-1
1.000E0
 1 9
45 GO:0030853 negative regulation of granulocyte differentiation 3.753E-3 2.440E-2
1.532E-1
1.000E0
 1 10
46 GO:0072364 regulation of cellular ketone metabolic process by regulation of transcription from RNA polymerase II promoter 3.753E-3 2.440E-2
1.532E-1
1.000E0
 1 10
47 GO:0030854 positive regulation of granulocyte differentiation 4.128E-3 2.626E-2
1.649E-1
1.000E0
 1 11
48 GO:0045165 cell fate commitment 4.314E-3 2.687E-2
1.687E-1
1.000E0
 2 274
49 GO:0043588 skin development 4.438E-3 2.708E-2
1.700E-1
1.000E0
 2 278
50 GO:2000194 regulation of female gonad development 4.877E-3 2.859E-2
1.795E-1
1.000E0
 1 13
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 7 input genes in category / 8 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0000790 nuclear chromatin 5.717E-3 4.574E-2
1.243E-1
 4.574E-2 2 324

4: Human Phenotype [Display Chart] 3 input genes in category / 297 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 7 input genes in category / 756 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008080 abnormal CD8-positive, alpha-beta T cell differentiation 6.861E-7 3.189E-4 2.298E-3 5.187E-4 3 29
2 MP:0014105 abnormal chondrocyte differentiation 8.435E-7 3.189E-4 2.298E-3 6.377E-4 3 31
3 MP:0005298 abnormal clavicle morphology 2.308E-6 5.816E-4 4.191E-3 1.745E-3 3 43
4 MP:0008273 abnormal intramembranous bone ossification 7.383E-6 1.099E-3 7.921E-3 5.582E-3 3 63
5 MP:0004339 absent clavicle 8.213E-6 1.099E-3 7.921E-3 6.209E-3 2 7
6 MP:0002408 abnormal double-positive T cell morphology 8.724E-6 1.099E-3 7.921E-3 6.595E-3 4 236
7 MP:0008074 increased CD4-positive, alpha beta T cell number 1.045E-5 1.129E-3 8.135E-3 7.902E-3 4 247
8 MP:0000158 absent sternum 1.407E-5 1.317E-3 9.490E-3 1.064E-2 2 9
9 MP:0004508 abnormal pectoral girdle bone morphology 1.742E-5 1.317E-3 9.490E-3 1.317E-2 4 281
10 MP:0008079 decreased CD8-positive, alpha-beta T cell number 1.742E-5 1.317E-3 9.490E-3 1.317E-2 4 281
11 MP:0012764 increased alpha-beta T cell number 2.770E-5 1.763E-3 1.271E-2 2.094E-2 4 316
12 MP:0000166 abnormal chondrocyte morphology 2.799E-5 1.763E-3 1.271E-2 2.116E-2 3 98
13 MP:0000968 abnormal sensory neuron innervation pattern 4.405E-5 2.562E-3 1.846E-2 3.330E-2 3 114
14 MP:0030437 abnormal osteoblast proliferation 5.963E-5 2.873E-3 2.070E-2 4.508E-2 2 18
15 MP:0000405 abnormal auchene hair morphology 5.963E-5 2.873E-3 2.070E-2 4.508E-2 2 18
16 MP:0008077 abnormal CD8-positive, alpha-beta T cell number 6.998E-5 2.873E-3 2.070E-2
5.291E-2
 4 400
17 MP:0012765 decreased alpha-beta T cell number 7.067E-5 2.873E-3 2.070E-2
5.343E-2
 4 401
18 MP:0005312 pericardial effusion 7.965E-5 2.873E-3 2.070E-2
6.021E-2
 3 139
19 MP:0002145 abnormal T cell differentiation 8.955E-5 2.873E-3 2.070E-2
6.770E-2
 4 426
20 MP:0005435 hemoperitoneum 8.991E-5 2.873E-3 2.070E-2
6.797E-2
 2 22
21 MP:0001917 intraventricular hemorrhage 8.991E-5 2.873E-3 2.070E-2
6.797E-2
 2 22
22 MP:0000060 delayed bone ossification 9.034E-5 2.873E-3 2.070E-2
6.829E-2
 3 145
23 MP:0005010 abnormal CD8-positive, alpha beta T cell morphology 9.038E-5 2.873E-3 2.070E-2
6.833E-2
 4 427
24 MP:0002339 abnormal lymph node morphology 9.121E-5 2.873E-3 2.070E-2
6.895E-2
 4 428
25 MP:0008271 abnormal bone ossification 1.081E-4 3.265E-3 2.353E-2
8.171E-2
 4 447
26 MP:0006054 spinal hemorrhage 1.167E-4 3.265E-3 2.353E-2
8.819E-2
 2 25
27 MP:0008133 decreased Peyer's patch number 1.167E-4 3.265E-3 2.353E-2
8.819E-2
 2 25
28 MP:0004986 abnormal osteoblast morphology 1.211E-4 3.265E-3 2.353E-2
9.154E-2
 3 160
29 MP:0008131 abnormal Peyer's patch number 1.263E-4 3.265E-3 2.353E-2
9.551E-2
 2 26
30 MP:0008073 abnormal CD4-positive, alpha beta T cell number 1.315E-4 3.265E-3 2.353E-2
9.939E-2
 4 470
31 MP:0008150 decreased diameter of long bones 1.364E-4 3.265E-3 2.353E-2
1.031E-1
 2 27
32 MP:0000240 extramedullary hematopoiesis 1.424E-4 3.265E-3 2.353E-2
1.077E-1
 3 169
33 MP:0008255 decreased megakaryocyte cell number 1.468E-4 3.265E-3 2.353E-2
1.110E-1
 2 28
34 MP:0002450 abnormal lymph organ development 1.468E-4 3.265E-3 2.353E-2
1.110E-1
 2 28
35 MP:0000402 abnormal zigzag hair morphology 1.577E-4 3.311E-3 2.386E-2
1.192E-1
 2 29
36 MP:0011711 impaired osteoblast differentiation 1.577E-4 3.311E-3 2.386E-2
1.192E-1
 2 29
37 MP:0003420 delayed intramembranous bone ossification 1.805E-4 3.590E-3 2.587E-2
1.364E-1
 2 31
38 MP:0000229 abnormal megakaryocyte differentiation 1.805E-4 3.590E-3 2.587E-2
1.364E-1
 2 31
39 MP:0000715 decreased thymocyte number 1.893E-4 3.669E-3 2.644E-2
1.431E-1
 3 186
40 MP:0005092 decreased double-positive T cell number 2.210E-4 4.177E-3 3.010E-2
1.671E-1
 3 196
41 MP:0008078 increased CD8-positive, alpha-beta T cell number 2.452E-4 4.478E-3 3.227E-2
1.853E-1
 3 203
42 MP:0002896 abnormal bone mineralization 2.488E-4 4.478E-3 3.227E-2
1.881E-1
 3 204
43 MP:0001255 decreased body height 2.722E-4 4.677E-3 3.370E-2
2.058E-1
 2 38
44 MP:0001253 abnormal body height 2.722E-4 4.677E-3 3.370E-2
2.058E-1
 2 38
45 MP:0001861 lung inflammation 2.826E-4 4.747E-3 3.421E-2
2.136E-1
 3 213
46 MP:0003072 abnormal metatarsal bone morphology 3.172E-4 5.213E-3 3.757E-2
2.398E-1
 2 41
47 MP:0000157 abnormal sternum morphology 3.322E-4 5.343E-3 3.850E-2
2.511E-1
 3 225
48 MP:0003717 pallor 3.409E-4 5.370E-3 3.869E-2
2.578E-1
 3 227
49 MP:0000972 abnormal mechanoreceptor morphology 3.499E-4 5.398E-3 3.890E-2
2.645E-1
 3 229
50 MP:0003073 abnormal metacarpal bone morphology 3.656E-4 5.528E-3 3.983E-2
2.764E-1
 2 44
Show 45 more annotations

6: Domain [Display Chart] 7 input genes in category / 53 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR000040 AML1 Runt InterPro 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
2 IPR013524 Runt dom InterPro 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
3 PF00853 Runt Pfam 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
4 PF08504 RunxI Pfam 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
5 IPR013711 RunxI C dom InterPro 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
6 IPR027384 Runx central dom InterPro 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
7 4.10.770.10 - Gene3D 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
8 IPR016554 TF Runt-rel RUNX InterPro 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
9 PS51062 RUNT PROSITE 3.194E-11 1.881E-10 8.571E-10 1.693E-9 3 3
10 2.60.40.720 - Gene3D 6.385E-10 3.076E-9 1.402E-8 3.384E-8 3 6
11 IPR012346 p53/RUNT-type TF DNA-bd InterPro 6.385E-10 3.076E-9 1.402E-8 3.384E-8 3 6
12 IPR008967 p53-like TF DNA-bd InterPro 7.422E-7 3.278E-6 1.494E-5 3.934E-5 3 53
13 2.40.250.10 - Gene3D 3.736E-4 1.238E-3 5.640E-3 1.980E-2 1 1
14 IPR013290 CBFA2T1 InterPro 3.736E-4 1.238E-3 5.640E-3 1.980E-2 1 1
15 PF02312 CBF beta Pfam 3.736E-4 1.238E-3 5.640E-3 1.980E-2 1 1
16 IPR003417 CBF beta InterPro 3.736E-4 1.238E-3 5.640E-3 1.980E-2 1 1
17 PF16675 FOXO KIX bdg Pfam 7.471E-4 2.200E-3 1.002E-2 3.960E-2 1 2
18 IPR032068 FOXO KIX-bd InterPro 7.471E-4 2.200E-3 1.002E-2 3.960E-2 1 2
19 IPR013289 CBFA2T1/2/3 InterPro 1.121E-3 2.582E-3 1.177E-2
5.939E-2
 1 3
20 IPR014896 NHR2 InterPro 1.121E-3 2.582E-3 1.177E-2
5.939E-2
 1 3
21 PF08788 NHR2 Pfam 1.121E-3 2.582E-3 1.177E-2
5.939E-2
 1 3
22 PF16676 FOXO-TAD Pfam 1.121E-3 2.582E-3 1.177E-2
5.939E-2
 1 3
23 IPR032067 FOXO-TAD InterPro 1.121E-3 2.582E-3 1.177E-2
5.939E-2
 1 3
24 SM00549 TAFH SMART 1.867E-3 3.665E-3 1.670E-2
9.895E-2
 1 5
25 IPR003894 TAFH NHR1 InterPro 1.867E-3 3.665E-3 1.670E-2
9.895E-2
 1 5
26 PF07531 TAFH Pfam 1.867E-3 3.665E-3 1.670E-2
9.895E-2
 1 5
27 PS51119 TAFH PROSITE 1.867E-3 3.665E-3 1.670E-2
9.895E-2
 1 5
28 IPR013144 CRA dom InterPro 2.240E-3 3.830E-3 1.745E-2
1.187E-1
 1 6
29 IPR024964 CTLH/CRA InterPro 2.240E-3 3.830E-3 1.745E-2
1.187E-1
 1 6
30 SM00757 CRA SMART 2.240E-3 3.830E-3 1.745E-2
1.187E-1
 1 6
31 PF10607 CLTH Pfam 2.240E-3 3.830E-3 1.745E-2
1.187E-1
 1 6
32 SM00668 CTLH SMART 3.358E-3 5.562E-3 2.535E-2
1.780E-1
 1 9
33 IPR006595 CTLH C InterPro 3.731E-3 5.816E-3 2.650E-2
1.977E-1
 1 10
34 PS50897 CTLH PROSITE 3.731E-3 5.816E-3 2.650E-2
1.977E-1
 1 10
35 PF01753 zf-MYND Pfam 7.821E-3 1.143E-2
5.207E-2
4.145E-1
 1 21
36 PS01360 ZF MYND 1 PROSITE 8.192E-3 1.143E-2
5.207E-2
4.342E-1
 1 22
37 PS50865 ZF MYND 2 PROSITE 8.192E-3 1.143E-2
5.207E-2
4.342E-1
 1 22
38 IPR002893 Znf MYND InterPro 8.192E-3 1.143E-2
5.207E-2
4.342E-1
 1 22
39 SM00667 LisH SMART 1.042E-2 1.347E-2
6.136E-2
5.521E-1
 1 28
40 PS50896 LISH PROSITE 1.042E-2 1.347E-2
6.136E-2
5.521E-1
 1 28
41 IPR006594 LisH InterPro 1.042E-2 1.347E-2
6.136E-2
5.521E-1
 1 28
42 IPR030456 TF fork head CS 2 InterPro 1.706E-2 2.005E-2
9.136E-2
9.044E-1
 1 46
43 IPR018122 TF fork head CS 1 InterPro 1.780E-2 2.005E-2
9.136E-2
9.434E-1
 1 48
44 SM00339 FH SMART 1.854E-2 2.005E-2
9.136E-2
9.824E-1
 1 50
45 PF00250 Forkhead Pfam 1.854E-2 2.005E-2
9.136E-2
9.824E-1
 1 50
46 PS00658 FORK HEAD 2 PROSITE 1.854E-2 2.005E-2
9.136E-2
9.824E-1
 1 50
47 IPR001766 Fork head dom InterPro 1.854E-2 2.005E-2
9.136E-2
9.824E-1
 1 50
48 PS00657 FORK HEAD 1 PROSITE 1.854E-2 2.005E-2
9.136E-2
9.824E-1
 1 50
49 PS50039 FORK HEAD 3 PROSITE 1.854E-2 2.005E-2
9.136E-2
9.824E-1
 1 50
Show 44 more annotations

7: Pathway [Display Chart] 6 input genes in category / 64 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PW:0000490 transforming growth factor-beta Smad dependent signaling Pathway Ontology 2.235E-10 1.430E-8 6.785E-8 1.430E-8 4 26
2 523016 Transcriptional misregulation in cancer BioSystems: KEGG 6.198E-7 1.983E-5 9.409E-5 3.967E-5 4 180
3 137963 Regulation of nuclear SMAD2/3 signaling BioSystems: Pathway Interaction Database 4.489E-6 9.577E-5 4.543E-4 2.873E-4 3 77
4 83117 Acute myeloid leukemia BioSystems: KEGG 2.842E-4 4.547E-3 2.157E-2 1.819E-2 2 55
5 83105 Pathways in cancer BioSystems: KEGG 5.902E-4 7.555E-3 3.584E-2 3.777E-2 3 395
6 1270342 AKT-mediated inactivation of FOXO1A BioSystems: REACTOME 1.927E-3 2.055E-2
9.749E-2
1.233E-1
 1 4
7 1269190 AKT phosphorylates targets in the nucleus BioSystems: REACTOME 4.330E-3 3.959E-2
1.878E-1
2.771E-1
 1 9
8 1269937 Organic cation transport BioSystems: REACTOME 5.291E-3 4.232E-2
2.008E-1
3.386E-1
 1 11
Show 3 more annotations

8: Pubmed [Display Chart] 7 input genes in category / 3817 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 26001080 Central Role of Core Binding Factor β2 in Mucosa-Associated Lymphoid Tissue Organogenesis in Mouse. Pubmed 3.948E-16 3.768E-13 3.325E-12 1.507E-12 4 4
2 8437866 Isolation of PEBP2 alpha B cDNA representing the mouse homolog of human acute myeloid leukemia gene, AML1. Pubmed 3.948E-16 3.768E-13 3.325E-12 1.507E-12 4 4
3 12807883 Mutagenesis of the Runt domain defines two energetic hot spots for heterodimerization with the core binding factor beta subunit. Pubmed 3.948E-16 3.768E-13 3.325E-12 1.507E-12 4 4
4 20306685 Dual color FISH on CBF primary acute myeloid leukemia. Pubmed 3.948E-16 3.768E-13 3.325E-12 1.507E-12 4 4
5 24677539 Runx1 and Cbfβ regulate the development of Flt3+ dendritic cell progenitors and restrict myeloproliferative disorder. Pubmed 5.922E-15 4.521E-12 3.989E-11 2.260E-11 4 6
6 15331439 Physical and functional link of the leukemia-associated factors AML1 and PML. Pubmed 1.382E-14 8.790E-12 7.756E-11 5.274E-11 4 7
7 25410786 Runx/Cbfb signaling regulates postnatal development of granular convoluted tubule in the mouse submandibular gland. Pubmed 1.302E-13 7.102E-11 6.267E-10 4.971E-10 4 11
8 26890219 Cbfb2 Isoform Dominates More Potent Cbfb1 and Is Required for Skeletal Development. Pubmed 3.950E-13 1.885E-10 1.663E-9 1.508E-9 4 14
9 25262822 Cbfb regulates bone development by stabilizing Runx family proteins. Pubmed 7.181E-13 3.045E-10 2.687E-9 2.741E-9 4 16
10 8497254 Cloning and characterization of subunits of the T-cell receptor and murine leukemia virus enhancer core-binding factor. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
11 28530640 Genetic regulation of the RUNX transcription factor family has antitumor effects. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
12 15386419 Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
13 15713794 Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
14 7835892 AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
15 12617847 Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
16 23532528 Transcription factors Runx1 to 3 are expressed in the lacrimal gland epithelium and are involved in regulation of gland morphogenesis and regeneration. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
17 29222089 Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
18 11483356 Identification and comparative analysis of a second runx3 promoter. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
19 14516670 Expression of Runx1, -2 and -3 during tooth, palate and craniofacial bone development. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
20 12217689 The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding. Pubmed 3.770E-12 7.194E-10 6.349E-9 1.439E-8 3 3
21 19419310 Dose-dependent effects of Runx2 on bone development. Pubmed 6.919E-12 1.258E-9 1.110E-8 2.641E-8 4 27
22 20236534 Evolution of the interaction between Runx2 and VDR, two transcription factors involved in osteoblastogenesis. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
23 17646405 Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
24 19917773 Transcription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
25 25185713 The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
26 19800266 Indispensable role of the Runx1-Cbfbeta transcription complex for in vivo-suppressive function of FoxP3+ regulatory T cells. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
27 19179469 CBFbeta is critical for AML1-ETO and TEL-AML1 activity. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
28 29107070 Inflammation-driven colon neoplasmatogenesis in uPA-deficient mice is associated with an increased expression of Runx transcriptional regulators. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
29 12464175 Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
30 10228168 A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. Pubmed 1.508E-11 1.918E-9 1.693E-8 5.755E-8 3 4
31 25066130 Disruption of Runx1 and Runx3 leads to bone marrow failure and leukemia predisposition due to transcriptional and DNA repair defects. Pubmed 3.769E-11 3.996E-9 3.527E-8 1.439E-7 3 5
32 22665574 Runx1-Cbfβ facilitates early B lymphocyte development by regulating expression of Ebf1. Pubmed 3.769E-11 3.996E-9 3.527E-8 1.439E-7 3 5
33 18258917 Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development. Pubmed 3.769E-11 3.996E-9 3.527E-8 1.439E-7 3 5
34 7862157 Expression of the Runt domain-encoding PEBP2 alpha genes in T cells during thymic development. Pubmed 3.769E-11 3.996E-9 3.527E-8 1.439E-7 3 5
35 17377532 Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Pubmed 3.769E-11 3.996E-9 3.527E-8 1.439E-7 3 5
36 9794229 Transcriptional regulation of osteopontin gene in vivo by PEBP2alphaA/CBFA1 and ETS1 in the skeletal tissues. Pubmed 3.769E-11 3.996E-9 3.527E-8 1.439E-7 3 5
37 20152828 The essential requirement for Runx1 in the development of the sternum. Pubmed 7.538E-11 7.377E-9 6.510E-8 2.877E-7 3 6
38 9751710 Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. Pubmed 7.538E-11 7.377E-9 6.510E-8 2.877E-7 3 6
39 18776905 ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage. Pubmed 7.538E-11 7.377E-9 6.510E-8 2.877E-7 3 6
40 24505141 Bone morphogenic protein (BMP) signaling up-regulates neutral sphingomyelinase 2 to suppress chondrocyte maturation via the Akt protein signaling pathway as a negative feedback mechanism. Pubmed 1.319E-10 1.144E-8 1.010E-7 5.034E-7 3 7
41 20181744 Runx1 and Runx2 cooperate during sternal morphogenesis. Pubmed 1.319E-10 1.144E-8 1.010E-7 5.034E-7 3 7
42 18759297 The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease. Pubmed 1.319E-10 1.144E-8 1.010E-7 5.034E-7 3 7
43 21088106 Associations between genetic variation in RUNX1, RUNX2, RUNX3, MAPK1 and eIF4E and riskof colon and rectal cancer: additional support for a TGF-β-signaling pathway. Pubmed 1.319E-10 1.144E-8 1.010E-7 5.034E-7 3 7
44 24798493 Deletion of core-binding factor β (Cbfβ) in mesenchymal progenitor cells provides new insights into Cbfβ/Runxs complex function in cartilage and bone development. Pubmed 1.319E-10 1.144E-8 1.010E-7 5.034E-7 3 7
45 17142326 Dominance of SOX9 function over RUNX2 during skeletogenesis. Pubmed 2.110E-10 1.714E-8 1.512E-7 8.055E-7 3 8
46 21807129 Early onset of Runx2 expression caused craniosynostosis, ectopic bone formation, and limb defects. Pubmed 2.110E-10 1.714E-8 1.512E-7 8.055E-7 3 8
47 10531362 Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. Pubmed 2.110E-10 1.714E-8 1.512E-7 8.055E-7 3 8
48 8164679 PEBP2 alpha B/mouse AML1 consists of multiple isoforms that possess differential transactivation potentials. Pubmed 3.165E-10 2.517E-8 2.221E-7 1.208E-6 3 9
49 22498736 PRMT1 interacts with AML1-ETO to promote its transcriptional activation and progenitor cell proliferative potential. Pubmed 4.521E-10 3.522E-8 3.108E-7 1.726E-6 3 10
50 20195544 The core binding factor CBF negatively regulates skeletal muscle terminal differentiation. Pubmed 8.287E-10 6.327E-8 5.583E-7 3.163E-6 3 12
Show 45 more annotations

9: Interaction [Display Chart] 7 input genes in category / 322 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:CBFB CBFB interactions 4.461E-10 1.436E-7 9.126E-7 1.436E-7 4 35
2 int:CEBPB CEBPB interactions 2.927E-8 4.713E-6 2.994E-5 9.425E-6 4 97
3 int:RUNX1 RUNX1 interactions 6.464E-8 6.938E-6 4.408E-5 2.082E-5 4 118
4 int:CBFA2T2 CBFA2T2 interactions 1.530E-7 1.232E-5 7.825E-5 4.927E-5 3 30
5 int:RUNX3 RUNX3 interactions 4.640E-7 2.988E-5 1.899E-4 1.494E-4 3 43
6 int:CBFA2T3 CBFA2T3 interactions 6.093E-7 3.270E-5 2.077E-4 1.962E-4 3 47
7 int:PML PML interactions 1.634E-6 7.514E-5 4.774E-4 5.260E-4 4 264
8 int:SMAD5 SMAD5 interactions 2.525E-6 1.016E-4 6.458E-4 8.131E-4 3 75
9 int:SMAD3 SMAD3 interactions 7.170E-6 2.370E-4 1.505E-3 2.309E-3 4 383
10 int:KAT6B KAT6B interactions 7.359E-6 2.370E-4 1.505E-3 2.370E-3 2 11
11 int:TLE1 TLE1 interactions 9.659E-6 2.827E-4 1.796E-3 3.110E-3 3 117
12 int:FHL2 FHL2 interactions 2.246E-5 6.026E-4 3.828E-3 7.231E-3 3 155
13 int:SUV39H1 SUV39H1 interactions 3.872E-5 9.592E-4 6.094E-3 1.247E-2 3 186
14 int:SMAD1 SMAD1 interactions 4.191E-5 9.640E-4 6.125E-3 1.350E-2 3 191
15 int:COMMD3-BMI1 COMMD3-BMI1 interactions 5.414E-5 1.162E-3 7.384E-3 1.743E-2 2 29
16 int:COPRS COPRS interactions 8.390E-5 1.666E-3 1.058E-2 2.701E-2 2 36
17 int:HDAC3 HDAC3 interactions 8.796E-5 1.666E-3 1.058E-2 2.832E-2 3 245
18 int:SMAD2 SMAD2 interactions 1.700E-4 2.945E-3 1.871E-2
5.474E-2
 3 306
19 int:STUB1 STUB1 interactions 1.801E-4 2.945E-3 1.871E-2
5.798E-2
 3 312
20 int:SATB2 SATB2 interactions 1.829E-4 2.945E-3 1.871E-2
5.890E-2
 2 53
21 int:AR AR interactions 2.106E-4 3.229E-3 2.052E-2
6.782E-2
 3 329
22 int:SPEN SPEN interactions 2.269E-4 3.320E-3 2.110E-2
7.305E-2
 2 59
23 int:YAP1 YAP1 interactions 2.747E-4 3.647E-3 2.317E-2
8.845E-2
 3 360
24 int:RUNX2 RUNX2 interactions 2.755E-4 3.647E-3 2.317E-2
8.870E-2
 2 65
25 int:ETS1 ETS1 interactions 2.927E-4 3.647E-3 2.317E-2
9.426E-2
 2 67
26 int:HIF1A HIF1A interactions 3.074E-4 3.647E-3 2.317E-2
9.897E-2
 3 374
27 int:RUNX1T1 RUNX1T1 interactions 3.105E-4 3.647E-3 2.317E-2
9.997E-2
 2 69
28 int:HDAC2 HDAC2 interactions 3.171E-4 3.647E-3 2.317E-2
1.021E-1
 3 378
29 int:CREBBP CREBBP interactions 3.691E-4 4.043E-3 2.569E-2
1.188E-1
 3 398
30 int:NR0B2 NR0B2 interactions 3.767E-4 4.043E-3 2.569E-2
1.213E-1
 2 76
31 int:SIRT2 SIRT2 interactions 4.070E-4 4.227E-3 2.686E-2
1.310E-1
 2 79
32 int:TRIM33 TRIM33 interactions 4.822E-4 4.852E-3 3.082E-2
1.553E-1
 2 86
33 int:TCF12 TCF12 interactions 5.048E-4 4.926E-3 3.129E-2
1.625E-1
 2 88
34 int:DZIP3 DZIP3 interactions 5.397E-4 5.111E-3 3.247E-2
1.738E-1
 2 91
35 int:WWP1 WWP1 interactions 5.636E-4 5.185E-3 3.294E-2
1.815E-1
 2 93
36 int:MYOD1 MYOD1 interactions 6.129E-4 5.482E-3 3.483E-2
1.974E-1
 2 97
37 int:VDR VDR interactions 6.907E-4 6.011E-3 3.819E-2
2.224E-1
 2 103
38 int:HOXA-AS2 HOXA-AS2 interactions 7.907E-4 6.210E-3 3.945E-2
2.546E-1
 1 2
39 int:MEG8 MEG8 interactions 7.907E-4 6.210E-3 3.945E-2
2.546E-1
 1 2
40 int:RNF44 RNF44 interactions 7.907E-4 6.210E-3 3.945E-2
2.546E-1
 1 2
41 int:HIF1A-AS2 HIF1A-AS2 interactions 7.907E-4 6.210E-3 3.945E-2
2.546E-1
 1 2
42 int:DNMT1 DNMT1 interactions 8.305E-4 6.367E-3 4.045E-2
2.674E-1
 2 113
43 int:KMT2A KMT2A interactions 8.600E-4 6.440E-3 4.092E-2
2.769E-1
 2 115
44 int:NCOR2 NCOR2 interactions 1.182E-3 8.301E-3
5.274E-2
3.807E-1
 2 135
45 int:BSX BSX interactions 1.186E-3 8.301E-3
5.274E-2
3.818E-1
 1 3
46 int:GAS5 GAS5 interactions 1.186E-3 8.301E-3
5.274E-2
3.818E-1
 1 3
47 int:RBPJ RBPJ interactions 1.235E-3 8.460E-3
5.375E-2
3.976E-1
 2 138
48 int:SMURF2 SMURF2 interactions 1.289E-3 8.644E-3
5.492E-2
4.149E-1
 2 141
49 int:NFATC1 NFATC1 interactions 1.476E-3 9.698E-3
6.161E-2
4.752E-1
 2 151
50 int:CCNB1 CCNB1 interactions 1.515E-3 9.754E-3
6.197E-2
4.877E-1
 2 153
Show 45 more annotations

10: Cytoband [Display Chart] 7 input genes in category / 7 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 13q14.1 13q14.1 4.039E-4 2.827E-3 7.330E-3 2.827E-3 1 2
2 8q22 8q22 3.026E-3 1.059E-2 2.746E-2 2.118E-2 1 15
3 1p36 1p36 1.046E-2 2.145E-2
5.561E-2
7.319E-2
 1 52
4 6p21 6p21 1.226E-2 2.145E-2
5.561E-2
8.579E-2
 1 61
5 5q35.3 5q35.3 2.042E-2 2.660E-2
6.897E-2
1.429E-1
 1 102
6 16q22.1 16q22.1 2.280E-2 2.660E-2
6.897E-2
1.596E-1
 1 114
7 21q22.3 21q22.3 2.734E-2 2.734E-2
7.090E-2
1.914E-1
 1 137
Show 2 more annotations

11: Transcription Factor Binding Site [Display Chart] 5 input genes in category / 90 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 87 Zinc fingers MYND-type genenames.org 2.307E-3 4.614E-3 6.922E-3 4.614E-3 1 21
2 508 Forkhead boxes genenames.org 4.721E-3 4.721E-3 7.082E-3 9.443E-3 1 43

13: Coexpression [Display Chart] 7 input genes in category / 1164 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M9150 Genes from common genomic gains observed in a meta analyis of copy number alterations across a panel of different cancer cell lines and tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.262E-6 1.470E-3 1.122E-2 1.470E-3 4 323
2 16109776-TableS1 Human Leukemia Verhaak05 568genes GeneSigDB 3.831E-6 2.230E-3 1.703E-2 4.460E-3 4 427
3 M7219 Genes up-regulated in mouse embryonic fibroblasts (MEF): control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 2.139E-5 6.317E-3 4.825E-2 2.489E-2 3 199
4 M7147 Genes up-regulated in CD8A- [GeneID=925] splenic dendritic cells: wildtype versus IFNAR1 [GeneID=3454] knockout mice. MSigDB C7: Immunologic Signatures (v6.0) 2.171E-5 6.317E-3 4.825E-2 2.527E-2 3 200
5 17571080-SuppTable2b Human Leukemia Sun07 283genes GeneSigDB 3.788E-5 6.760E-3
5.163E-2
 4.409E-2 3 241
6 M10117 Genes down-regulated in acute myeloid leukemia (AML) patients with mutated NPM1 [GeneID=4869]. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.027E-5 6.760E-3
5.163E-2
 4.687E-2 3 246
7 M789 Genes down-regulated in primary fibroblast cell culture point after infection with HCMV (AD169 strain) at 4 h time point that were not down-regulated at the previous time point, 2 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.378E-5 6.760E-3
5.163E-2
5.096E-2
 3 253
8 M9326 Top 40 genes from cluster 9 of acute myeloid leukemia (AML) expression profile; 87% of the samples are FAB M4 or M5 subtype, all have inv(16) inversion producing the CBFB-MYH11 fusion [GeneID=865;4629]; indicate good survival. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.646E-5 6.760E-3
5.163E-2
5.408E-2
 2 35
9 M1978 Genes down-regulated in CD4+ [GeneID=920] T lymphocytes by expression of AML1 [GeneID=861] off a viral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.398E-5 7.807E-3
5.962E-2
7.447E-2
 2 41
10 M1982 Genes down-regulated in CD4+ [GeneID=920] T lymphocytes transduced with FOXP3 [GeneID=50943]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.717E-5 7.807E-3
5.962E-2
7.818E-2
 2 42
11 M15154 Interaction partners of class IIa histone deacetylases (HDAC). MSigDB C2: CGP Curated Gene Sets (v6.0) 7.378E-5 7.807E-3
5.962E-2
8.588E-2
 2 44
12 17123152-Table3a Human Breast Feng07 58genesDownRegulated GeneSigDB 1.114E-4 1.081E-2
8.256E-2
1.297E-1
 2 54
13 19137020-SuppTable2a Human StemCell Fukuzawa09 114genes GeneSigDB 1.424E-4 1.275E-2
9.736E-2
1.657E-1
 2 61
14 M1047 Genes specifically expressed in samples from patients with pediatric acute myeloid leukemia (AML) bearing inv(16) translocation. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.983E-4 1.649E-2
1.259E-1
2.308E-1
 3 421
15 M2339 Direct targets of PRDM5 [GeneID=11107]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.391E-4 1.855E-2
1.417E-1
2.783E-1
 2 79
16 M7804 Top 100 probe sets for core-binding factor (CBF) acute myeloid leukemia (AML): contains CBFB MYH11 [GeneID=865;4629] or AML1 ETO [GeneID=861;862] fusions. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.576E-4 1.874E-2
1.431E-1
2.998E-1
 2 82
17 M17860 Genes down-regulated in primary tissue culture of epidermal kerationcytes after UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.678E-4 2.393E-2
1.828E-1
4.281E-1
 2 98
18 M14079 Breast cancer compendium: 100 transcription regulators showing most correlated expression with the 9 'embryonic stem cell' transcription factors that are preferentially and coordinately overexpressed in the high-grade, ER-negative breast cancer tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.829E-4 2.393E-2
1.828E-1
4.457E-1
 2 100
19 M5775 Genes down-regulated in primary fibroblast cell culture after infection with HCMV (AD169 strain) at 12 h time point that were not down-regulated at the previous time point, 10 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.906E-4 2.393E-2
1.828E-1
4.547E-1
 2 101
20 M6683 Genes down-regulated in bone marrow-derived macrophages at 180 min of stimulation with IL10 [GeneID=3486] and LPS: wildtype versus IL6 [GeneID=3469] knockout. MSigDB C7: Immunologic Signatures (v6.0) 7.698E-4 2.849E-2
2.176E-1
8.960E-1
 2 142
21 M6808 Genes down-regulated in B lymphocytes treated by anti-HEL and expressing BCR [GeneID=613] fusions with: IgM versus IgMG. MSigDB C7: Immunologic Signatures (v6.0) 1.100E-3 2.849E-2
2.176E-1
1.000E0
 2 170
22 M6326 Genes up-regulated in spleen from wildtype mice: control versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.126E-3 2.849E-2
2.176E-1
1.000E0
 2 172
23 M6716 Genes up-regulated in endothelial cells: B. burgdoferi versus IFNG [GeneID=3459] and B. burgdoferi . MSigDB C7: Immunologic Signatures (v6.0) 1.139E-3 2.849E-2
2.176E-1
1.000E0
 2 173
24 M1911 Genes up-regulated in mast cells (MC) after stimulation with a bacterial lipopolysaccharide (LPS). MSigDB C2: CGP Curated Gene Sets (v6.0) 1.273E-3 2.849E-2
2.176E-1
1.000E0
 2 183
25 M4723 Genes down-regulated in normal hematopoietic progenitors by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.315E-3 2.849E-2
2.176E-1
1.000E0
 2 186
26 M2746 Genes up-regulated in JNK inhibitor-treated (SP600125[PubChem=8515]) keratinocytes. MSigDB C6: Oncogenic Signatures (v6.0) 1.371E-3 2.849E-2
2.176E-1
1.000E0
 2 190
27 M2630 Genes down-regulated in mouse fibroblasts over-expressing E2F1 [Gene ID=1869] gene. MSigDB C6: Oncogenic Signatures (v6.0) 1.400E-3 2.849E-2
2.176E-1
1.000E0
 2 192
28 M10021 Genes up-regulated in tumor associated macrophages conditioned by: glioblastoma versus colorectal adenocarcinoma. MSigDB C7: Immunologic Signatures (v6.0) 1.443E-3 2.849E-2
2.176E-1
1.000E0
 2 195
29 M4658 Genes up-regulated in comparison of naive CD8 T cells versus PD-1 low CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.473E-3 2.849E-2
2.176E-1
1.000E0
 2 197
30 M8003 Genes down-regulated in bone marrow-derived macrophages treated with IL4 [GeneID=3565] and rosiglitazone [PubChem=77999]: wildtype versus STAT6 [GeneID=6778] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 2.849E-2
2.176E-1
1.000E0
 2 198
31 M6491 Genes up-regulated in monocyte-derived dendritic cells: LPS like antigen from O. planktothrix (3h) versus LPS and LPS like antigen from O. planktothrix (3h). MSigDB C7: Immunologic Signatures (v6.0) 1.488E-3 2.849E-2
2.176E-1
1.000E0
 2 198
32 M8356 Genes down-regulated in atherosclerosis macrophages: control anti miR ctrl versus untreated. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.849E-2
2.176E-1
1.000E0
 2 199
33 M8418 Genes up-regulated in brain dendritic cells versus bone marrow monocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.502E-3 2.849E-2
2.176E-1
1.000E0
 2 199
34 17899370-Table2 Human Breast Singer08 06genes GeneSigDB 1.512E-3 2.849E-2
2.176E-1
1.000E0
 1 5
35 M17966 Genes that best predicted acute myeloid leukemia (AML) with the t(8;21) translocation producing the AML1-ETO fusion [GeneID=861;862]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.512E-3 2.849E-2
2.176E-1
1.000E0
 1 5
36 M6646 Genes down-regulated in bone marrow-derived macrophages at 45 min of stimulation by IL6 [GeneID=3469] and LPS: wildtype versus IL6 [GeneID=3469] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
37 M5750 Genes down-regulated in comparison of thymus conventional T cells versus fat tissue conventional T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
38 M5514 Genes down-regulated in comparison of macrophages versus Th2 cells. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
39 M5070 Genes down-regulated in comparison of CD4+ [GeneID=920] CD8- thymocytes versus CD4- [GeneID=920] CD8+ thymocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
40 M3846 Genes up-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 24 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 24 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
41 M6357 Genes up-regulated in Vd1 gamma delta T cells: untreated versus LPS. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
42 M6207 Genes up-regulated in polymorphonuclear leukocytes 9h after infection by: S. aureus versus A. phagocytophilum. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
43 M5367 Genes up-regulated in comparison of untreated macrophages versus macrophages treated with LPS (TLR4 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
44 M7294 Genes up-regulated in T reg cells (2h): medium versus TNF [GeneID=7124]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
45 M6172 Genes down-regulated in D10.G4.1 T cell line (6h): control versus treated with NMU [GeneID=10874]. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
46 M5697 Genes down-regulated in comparsion of WTActCD4 versus WTActCD4TGF (see Fig. 1 in the paper for details). MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
47 M8260 Genes up-regulated in B lymphocytes: wildtype versus NFATC1 [GeneID=4772] knockout. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
48 M5720 Genes up-regulated in comparison of NK cells versus total splenocytes. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
49 M9925 Genes down-regulated in B lymphocytes: untreated versus anti-IgM for 24h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
50 M4050 Genes up-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 6 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 1.517E-3 2.849E-2
2.176E-1
1.000E0
 2 200
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 7 input genes in category / 1006 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 200 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 9.093E-8 9.147E-5 6.853E-4 9.147E-5 4 158
2 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 3.400E-6 1.647E-3 1.234E-2 3.420E-3 4 391
3 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.913E-6 1.647E-3 1.234E-2 4.942E-3 4 429
4 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 1.503E-5 3.138E-3 2.351E-2 1.512E-2 2 19
5 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 200 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.560E-5 3.138E-3 2.351E-2 1.569E-2 3 169
6 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 200 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 2.635E-5 4.418E-3 3.310E-2 2.651E-2 2 25
7 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 500 k1 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.873E-5 1.419E-2
1.063E-1
9.932E-2
 2 48
8 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 1000 k4 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#4 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 1.445E-4 1.564E-2
1.172E-1
1.453E-1
 2 58
9 gudmap developingLowerUrinaryTract adult ureter 200 k1 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#1 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 1.495E-4 1.564E-2
1.172E-1
1.504E-1
 2 59
10 GSM476681 500 gamma delta T cells, Tgd.vg2-.act.Sp, TCRd+ Vg2- CD44+, Spleen, avg-3 Immgen.org, GSE15907 1.699E-4 1.564E-2
1.172E-1
1.709E-1
 3 377
11 GSM476678 500 gamma delta T cells, Tgd.vg2+.act.Sp, TCRd+ Vg2+ CD44+, Spleen, avg-3 Immgen.org, GSE15907 1.950E-4 1.564E-2
1.172E-1
1.961E-1
 3 395
12 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#2 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.229E-4 1.564E-2
1.172E-1
2.242E-1
 2 72
13 Facebase ST1 e10.5 NeuroEpith MedialEmin 500 3 e10.5 NeuroEpith MedialEmin top-relative-expression-ranked 500 3 FaceBase_ST1 2.229E-4 1.564E-2
1.172E-1
2.242E-1
 2 72
14 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 1000 k2 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#2 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 2.355E-4 1.564E-2
1.172E-1
2.369E-1
 2 74
15 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 500 k4 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#4 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.419E-4 1.564E-2
1.172E-1
2.433E-1
 2 75
16 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 500 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 2.488E-4 1.564E-2
1.172E-1
2.502E-1
 3 429
17 Facebase RNAseq ratio e10.5 MaxillaryArch vs Mandibular 100 FacebaseRNAseq ratio e10.5 MaxillaryArch vs Mandibular top-relative-expression-ranked 100 FaceBase_RNAseq 4.045E-4 2.307E-2
1.729E-1
4.069E-1
 2 97
18 gudmap developingLowerUrinaryTract e14.5 Genital tubercle F 1000 k3 DevelopingLowerUrinaryTract e14.5 Genital tubercle F emap-6706 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 4.129E-4 2.307E-2
1.729E-1
4.153E-1
 2 98
19 gudmap developingLowerUrinaryTract e14.5 Genital tubercle 1000 k5 DevelopingLowerUrinaryTract e14.5 Genital tubercle emap-6706 k-means-cluster#5 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.104E-4 2.702E-2
2.025E-1
5.135E-1
 2 109
20 gudmap developingLowerUrinaryTract e14.5 Genital tubercle M 1000 k3 DevelopingLowerUrinaryTract e14.5 Genital tubercle M emap-6706 k-means-cluster#3 top-relative-expression-ranked 1000 Gudmap Mouse MOE430.2 5.978E-4 2.864E-2
2.145E-1
6.014E-1
 2 118
21 ratio EB vs SC 1000 K2 ratio EmbryoidBody vs StemCell top-relative-expression-ranked 1000 k-means-cluster#2 PCBC 5.978E-4 2.864E-2
2.145E-1
6.014E-1
 2 118
22 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Non-Papillary Muscle Invasive Urothelial Carcinoma/5/0 Sample Type by Project: Shred 1/TCGA-Bladder/Urothelial Carcinoma/Non-Papillary Muscle Invasive Urothelial Carcinoma/5/0 TCGA-Bladder 8.279E-4 3.786E-2
2.836E-1
8.329E-1
 2 139
23 gudmap developingLowerUrinaryTract adult ureter 500 k1 DevelopingLowerUrinaryTract adult ureter emap-29479 k-means-cluster#1 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 9.503E-4 4.037E-2
3.024E-1
9.560E-1
 2 149
24 gudmap developingLowerUrinaryTract adult ureter 200 DevelopingLowerUrinaryTract adult ureter emap-29479 top-relative-expression-ranked 200 Gudmap Mouse MOE430.2 9.630E-4 4.037E-2
3.024E-1
9.688E-1
 2 150
Show 19 more annotations

15: Computational [Display Chart] 7 input genes in category / 77 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 7 input genes in category / 661 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1305:PITA hsa-miR-1305:PITA TOP PITA 5.261E-8 1.801E-5 1.274E-4 3.478E-5 4 453
2 hsa-miR-582-5p:TargetScan hsa-miR-582-5p TargetScan 5.450E-8 1.801E-5 1.274E-4 3.602E-5 4 457
3 hsa-miR-584:PITA hsa-miR-584:PITA TOP PITA 5.740E-7 1.265E-4 8.943E-4 3.794E-4 3 185
4 CACTTTG,MIR-520G:MSigDB CACTTTG,MIR-520G:MSigDB MSigDB 1.020E-6 1.331E-4 9.415E-4 6.743E-4 3 224
5 CACTTTG,MIR-520H:MSigDB CACTTTG,MIR-520H:MSigDB MSigDB 1.020E-6 1.331E-4 9.415E-4 6.743E-4 3 224
6 hsa-miR-34c-3p:PITA hsa-miR-34c-3p:PITA TOP PITA 1.208E-6 1.331E-4 9.415E-4 7.988E-4 3 237
7 hsa-miR-605:PITA hsa-miR-605:PITA TOP PITA 2.214E-6 2.091E-4 1.479E-3 1.464E-3 3 290
8 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 4.820E-6 3.540E-4 2.504E-3 3.186E-3 3 376
9 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 4.820E-6 3.540E-4 2.504E-3 3.186E-3 3 376
10 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 8.086E-6 3.962E-4 2.802E-3 5.345E-3 3 447
11 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 8.086E-6 3.962E-4 2.802E-3 5.345E-3 3 447
12 hsa-miR-320a:PITA hsa-miR-320a:PITA TOP PITA 1.007E-5 3.962E-4 2.802E-3 6.653E-3 3 481
13 hsa-miR-320b:PITA hsa-miR-320b:PITA TOP PITA 1.007E-5 3.962E-4 2.802E-3 6.653E-3 3 481
14 hsa-miR-320c:PITA hsa-miR-320c:PITA TOP PITA 1.007E-5 3.962E-4 2.802E-3 6.653E-3 3 481
15 hsa-miR-320d:PITA hsa-miR-320d:PITA TOP PITA 1.007E-5 3.962E-4 2.802E-3 6.653E-3 3 481
16 TTTGCAC,MIR-19A:MSigDB TTTGCAC,MIR-19A:MSigDB MSigDB 1.019E-5 3.962E-4 2.802E-3 6.736E-3 3 483
17 TTTGCAC,MIR-19B:MSigDB TTTGCAC,MIR-19B:MSigDB MSigDB 1.019E-5 3.962E-4 2.802E-3 6.736E-3 3 483
18 hsa-miR-135b-5p:Functional MTI Functional MTI miRTarbase 2.729E-5 9.957E-4 7.042E-3 1.804E-2 2 83
19 hsa-miR-153-3p:Functional MTI Functional MTI miRTarbase 2.862E-5 9.957E-4 7.042E-3 1.892E-2 2 85
20 hsa-miR-4802-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.210E-5 1.061E-3 7.503E-3 2.122E-2 2 90
21 hsa-miR-135a-5p:Functional MTI Functional MTI miRTarbase 3.503E-5 1.075E-3 7.602E-3 2.315E-2 2 94
22 hsa-miR-324-5p:PITA hsa-miR-324-5p:PITA TOP PITA 3.578E-5 1.075E-3 7.602E-3 2.365E-2 2 95
23 ATGCTGG,MIR-338:MSigDB ATGCTGG,MIR-338:MSigDB MSigDB 4.714E-5 1.355E-3 9.580E-3 3.116E-2 2 109
24 hsa-miR-486-5p:PITA hsa-miR-486-5p:PITA TOP PITA 6.606E-5 1.819E-3 1.287E-2 4.366E-2 2 129
25 hsa-miR-505-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.128E-5 1.839E-3 1.301E-2 4.712E-2 2 134
26 TGTATGA,MIR-485-3P:MSigDB TGTATGA,MIR-485-3P:MSigDB MSigDB 7.235E-5 1.839E-3 1.301E-2 4.782E-2 2 135
27 hsa-miR-382-5p:TargetScan hsa-miR-382-5p TargetScan 8.696E-5 2.129E-3 1.505E-2
5.748E-2
 2 148
28 hsa-miR-192-5p:TargetScan hsa-miR-192-5p TargetScan 1.055E-4 2.217E-3 1.568E-2
6.972E-2
 2 163
29 hsa-miR-215-5p:TargetScan hsa-miR-215-5p TargetScan 1.055E-4 2.217E-3 1.568E-2
6.972E-2
 2 163
30 hsa-miR-490-3p:TargetScan hsa-miR-490-3p TargetScan 1.081E-4 2.217E-3 1.568E-2
7.144E-2
 2 165
31 hsa-miR-1270:PITA hsa-miR-1270:PITA TOP PITA 1.094E-4 2.217E-3 1.568E-2
7.230E-2
 2 166
32 hsa-miR-620:PITA hsa-miR-620:PITA TOP PITA 1.094E-4 2.217E-3 1.568E-2
7.230E-2
 2 166
33 hsa-miR-562:PITA hsa-miR-562:PITA TOP PITA 1.107E-4 2.217E-3 1.568E-2
7.318E-2
 2 167
34 GCAAAAA,MIR-129:MSigDB GCAAAAA,MIR-129:MSigDB MSigDB 1.202E-4 2.336E-3 1.652E-2
7.943E-2
 2 174
35 hsa-miR-1278:PITA hsa-miR-1278:PITA TOP PITA 1.344E-4 2.538E-3 1.794E-2
8.881E-2
 2 184
36 hsa-miR-556-3p:PITA hsa-miR-556-3p:PITA TOP PITA 1.433E-4 2.630E-3 1.860E-2
9.469E-2
 2 190
37 hsa-miR-210:mirSVR highEffct hsa-miR-210:mirSVR conserved highEffect-0.5 MicroRNA.org 1.493E-4 2.651E-3 1.875E-2
9.871E-2
 2 194
38 hsa-miR-508-5p:PITA hsa-miR-508-5p:PITA TOP PITA 1.524E-4 2.651E-3 1.875E-2
1.008E-1
 2 196
39 CTATGCA,MIR-153:MSigDB CTATGCA,MIR-153:MSigDB MSigDB 1.619E-4 2.744E-3 1.940E-2
1.070E-1
 2 202
40 hsa-miR-338-3p:PITA hsa-miR-338-3p:PITA TOP PITA 1.867E-4 2.993E-3 2.117E-2
1.234E-1
 2 217
41 hsa-miR-654-3p:PITA hsa-miR-654-3p:PITA TOP PITA 1.902E-4 2.993E-3 2.117E-2
1.257E-1
 2 219
42 hsa-miR-7111-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.902E-4 2.993E-3 2.117E-2
1.257E-1
 2 219
43 hsa-miR-892b:PITA hsa-miR-892b:PITA TOP PITA 1.954E-4 3.004E-3 2.124E-2
1.292E-1
 2 222
44 AACTGGA,MIR-145:MSigDB AACTGGA,MIR-145:MSigDB MSigDB 2.007E-4 3.016E-3 2.133E-2
1.327E-1
 2 225
45 hsa-miR-223:PITA hsa-miR-223:PITA TOP PITA 2.115E-4 3.107E-3 2.197E-2
1.398E-1
 2 231
46 GTTTGTT,MIR-495:MSigDB GTTTGTT,MIR-495:MSigDB MSigDB 2.208E-4 3.118E-3 2.205E-2
1.459E-1
 2 236
47 hsa-miR-1248:PITA hsa-miR-1248:PITA TOP PITA 2.226E-4 3.118E-3 2.205E-2
1.472E-1
 2 237
48 hsa-miR-1184:PITA hsa-miR-1184:PITA TOP PITA 2.264E-4 3.118E-3 2.205E-2
1.497E-1
 2 239
49 hsa-miR-127-5p:PITA hsa-miR-127-5p:PITA TOP PITA 2.437E-4 3.288E-3 2.325E-2
1.611E-1
 2 248
50 hsa-miR-455-3p:PITA hsa-miR-455-3p:PITA TOP PITA 2.596E-4 3.432E-3 2.427E-2
1.716E-1
 2 256
Show 45 more annotations

17: Drug [Display Chart] 7 input genes in category / 4372 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID011840919 A-K-V Stitch 1.764E-13 7.710E-10 6.909E-9 7.710E-10 5 37
2 CID000076336 RODAN Stitch 8.437E-11 1.844E-7 1.653E-6 3.689E-7 4 30
3 CID000032842 MDPC Stitch 2.530E-10 3.687E-7 3.303E-6 1.106E-6 4 39
4 CID000007870 2-methyl-2,4-pentanediol Stitch 9.394E-10 1.027E-6 9.200E-6 4.107E-6 5 197
5 CID005360741 alternariol monomethyl ether Stitch 4.146E-9 3.625E-6 3.248E-5 1.812E-5 4 77
6 CID000158781 olmesartan Stitch 8.175E-9 5.957E-6 5.338E-5 3.574E-5 4 91
7 CID000008534 alizarin red S Stitch 9.734E-9 6.079E-6 5.447E-5 4.256E-5 4 95
8 CID000014785 O-C-O Stitch 1.405E-8 7.154E-6 6.410E-5 6.141E-5 4 104
9 CID000003154 Cosopt Stitch 1.476E-8 7.154E-6 6.410E-5 6.453E-5 5 341
10 CID000025429 carbendazim Stitch 1.636E-8 7.154E-6 6.410E-5 7.154E-5 4 108
11 CID000000596 Cytosar-U Stitch 3.237E-8 1.287E-5 1.153E-4 1.415E-4 5 399
12 CID000005291 imatinib Stitch 4.704E-8 1.714E-5 1.536E-4 2.057E-4 5 430
13 CID000075347 decanamide Stitch 8.187E-8 2.720E-5 2.437E-4 3.579E-4 4 161
14 CID000656929 ahz Stitch 8.709E-8 2.720E-5 2.437E-4 3.807E-4 3 32
15 CID000011005 myristate Stitch 1.128E-6 3.288E-4 2.946E-3 4.931E-3 4 310
16 CID000005602 AC1L1KPQ Stitch 1.328E-6 3.628E-4 3.251E-3 5.805E-3 3 78
17 CID000005308 AC1L1K2B Stitch 1.229E-5 2.557E-3 2.291E-2
5.373E-2
 2 18
18 4271 UP Cloperastine hydrochloride [14984-68-0]; Up 200; 11uM; PC3; HT HG-U133A Broad Institute CMAP Up 1.816E-5 2.557E-3 2.291E-2
7.938E-2
 3 186
19 3807 UP Beta-Escin [11072-93-8]; Up 200; 3.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.028E-5 2.557E-3 2.291E-2
8.865E-2
 3 193
20 2391 UP Nortriptyline hydrochloride [894-71-3]; Up 200; 13.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.059E-5 2.557E-3 2.291E-2
9.003E-2
 3 194
21 4466 UP Rapamycin; Up 200; 0.1uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.059E-5 2.557E-3 2.291E-2
9.003E-2
 3 194
22 6647 DN Estrone [53-16-7]; Down 200; 14.8uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.091E-5 2.557E-3 2.291E-2
9.143E-2
 3 195
23 6194 UP genistein; Up 200; 10uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
24 5795 DN Demecarium bromide [56-94-0]; Down 200; 5.6uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
25 4390 UP Cefixime [79350-37-1]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
26 325 DN radicicol; Down 200; 0.1uM; MCF7; HG-U133A Broad Institute CMAP Down 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
27 4453 UP clozapine; Up 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
28 2019 UP Edrophonium chloride [116-38-1]; Up 200; 19.8uM; HL60; HG-U133A Broad Institute CMAP Up 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
29 3890 UP Beta-Escin [11072-93-8]; Up 200; 3.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
30 3394 UP Bretylium tosylate [61-75-6]; Up 200; 9.6uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.123E-5 2.557E-3 2.291E-2
9.284E-2
 3 196
31 7149 UP Aconitine [302-27-2]; Up 200; 6.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.156E-5 2.557E-3 2.291E-2
9.426E-2
 3 197
32 6389 DN 0225151-0000 [351320-15-5]; Down 200; 10uM; PC3; HT HG-U133A Broad Institute CMAP Down 2.156E-5 2.557E-3 2.291E-2
9.426E-2
 3 197
33 1528 UP Azathioprine [446-86-6]; Up 200; 14.4uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.156E-5 2.557E-3 2.291E-2
9.426E-2
 3 197
34 2374 UP Diphenidol hydrochloride [3254-89-5]; Up 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Up 2.156E-5 2.557E-3 2.291E-2
9.426E-2
 3 197
35 6473 UP S(-)-terguride hydrogen maleate [37686-85-4]; Up 200; 8.8uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.189E-5 2.557E-3 2.291E-2
9.570E-2
 3 198
36 7127 UP Monocrotaline [315-22-0]; Up 200; 12.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.189E-5 2.557E-3 2.291E-2
9.570E-2
 3 198
37 6520 UP Dimaprit dihydrochloride [23256-33-9]; Up 200; 17uM; MCF7; HT HG-U133A Broad Institute CMAP Up 2.189E-5 2.557E-3 2.291E-2
9.570E-2
 3 198
38 7281 UP Ozagrel hydrochloride [78712-43-3]; Up 200; 15.2uM; PC3; HT HG-U133A Broad Institute CMAP Up 2.222E-5 2.557E-3 2.291E-2
9.715E-2
 3 199
39 CID006334711 PM-81 Stitch 2.607E-5 2.923E-3 2.619E-2
1.140E-1
 2 26
40 CID000003496 glyphosate Stitch 2.800E-5 3.027E-3 2.712E-2
1.224E-1
 3 215
41 ctd:D006918 Hydroxyurea CTD 2.839E-5 3.027E-3 2.712E-2
1.241E-1
 3 216
42 CID000023985 gold nanoparticles Stitch 4.034E-5 4.199E-3 3.762E-2
1.763E-1
 3 243
43 CID005287919 C-GF Stitch 4.495E-5 4.571E-3 4.095E-2
1.965E-1
 2 34
44 CID000069736 6-hydroxymethylpterin Stitch 5.334E-5 5.183E-3 4.644E-2
2.332E-1
 2 37
45 CID005288236 5a-(3-formylphenylsulfanyl)-dihydrobicyclomycin Stitch 5.334E-5 5.183E-3 4.644E-2
2.332E-1
 2 37
46 CID000001744 AC1L1C56 Stitch 5.643E-5 5.315E-3 4.762E-2
2.467E-1
 3 272
47 CID000012967 N-ethyl-N-nitrosourea Stitch 5.830E-5 5.315E-3 4.762E-2
2.549E-1
 3 275
48 CID000398799 TC-6 Stitch 5.933E-5 5.315E-3 4.762E-2
2.594E-1
 2 39
49 CID000002735 vitamin D3 Stitch 5.957E-5 5.315E-3 4.762E-2
2.604E-1
 3 277
50 CID000002958 daunorubicin semiquinone Stitch 6.483E-5 5.669E-3
5.079E-2
2.834E-1
 3 285
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 542 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1533174 Acute myeloid leukemia, inv(16)(p13q22) DisGeNET BeFree 1.974E-10 1.070E-7 7.354E-7 1.070E-7 3 4
2 C3839741 Core binding factor acute myeloid leukemia DisGeNET BeFree 1.793E-8 4.859E-6 3.340E-5 9.718E-6 3 14
3 C1336735 Therapy-Related Acute Myeloid Leukemia DisGeNET BeFree 1.282E-6 2.317E-4 1.593E-3 6.951E-4 3 55
4 C0221013 Mastocytosis, Systemic DisGeNET Curated 2.444E-6 3.312E-4 2.276E-3 1.325E-3 3 68
5 C0023479 Acute myelomonocytic leukemia DisGeNET Curated 3.849E-6 4.172E-4 2.867E-3 2.086E-3 3 79
6 C0162679 Leukemic Infiltration DisGeNET BeFree 7.186E-6 5.949E-4 4.089E-3 3.895E-3 2 10
7 C0220621 pediatric acute myeloblastic leukemia DisGeNET BeFree 7.839E-6 5.949E-4 4.089E-3 4.249E-3 3 100
8 C3896960 Childhood Pre-B Acute Lymphoblastic Leukemia DisGeNET BeFree 8.781E-6 5.949E-4 4.089E-3 4.759E-3 2 11
9 C0521530 Lung consolidation DisGeNET BeFree 1.194E-5 7.188E-4 4.941E-3 6.469E-3 3 115
10 C0008928 Cleidocranial Dysplasia DisGeNET Curated 1.914E-5 9.430E-4 6.482E-3 1.037E-2 2 16
11 C0457334 Acute monoblastic leukemia DisGeNET BeFree 1.914E-5 9.430E-4 6.482E-3 1.037E-2 2 16
12 C0023470 Myeloid Leukemia DisGeNET Curated 2.561E-5 1.094E-3 7.520E-3 1.388E-2 4 484
13 C0085669 Acute leukemia DisGeNET Curated 2.710E-5 1.094E-3 7.520E-3 1.469E-2 4 491
14 C0008626 Congenital chromosomal disease DisGeNET Curated 2.888E-5 1.094E-3 7.520E-3 1.565E-2 4 499
15 C1879321 Acute Myeloid Leukemia (AML-M2) DisGeNET Curated 3.028E-5 1.094E-3 7.520E-3 1.641E-2 2 20
16 OMIN:601626 LEUKEMIA, ACUTE MYELOID; AML OMIM 4.395E-5 1.468E-3 1.009E-2 2.382E-2 2 24
17 C0152276 Granulocytic Sarcoma DisGeNET BeFree 4.776E-5 1.468E-3 1.009E-2 2.588E-2 2 25
18 C0346957 Disseminated Malignant Neoplasm DisGeNET BeFree 4.875E-5 1.468E-3 1.009E-2 2.642E-2 3 184
19 C0872084 Sarcopenia DisGeNET Curated 5.585E-5 1.593E-3 1.095E-2 3.027E-2 2 27
20 C0242596 Neoplasm, Residual DisGeNET Curated 8.411E-5 2.279E-3 1.567E-2 4.559E-2 3 221
21 C0220620 Gastrointestinal Carcinoid Tumor DisGeNET BeFree 9.108E-5 2.329E-3 1.601E-2 4.937E-2 3 227
22 C0036439 Scoliosis, unspecified DisGeNET Curated 9.452E-5 2.329E-3 1.601E-2
5.123E-2
 2 35
23 C1292778 Chronic myeloproliferative disorder DisGeNET BeFree 1.009E-4 2.379E-3 1.635E-2
5.471E-2
 3 235
24 C0027022 Myeloproliferative disease DisGeNET Curated 1.271E-4 2.871E-3 1.973E-2
6.891E-2
 3 254
25 C0264490 Acute respiratory failure DisGeNET BeFree 1.366E-4 2.961E-3 2.035E-2
7.403E-2
 2 42
26 C0018206 granulosa cell tumor DisGeNET BeFree 1.713E-4 3.571E-3 2.455E-2
9.285E-2
 2 47
27 C0035436 Rheumatic Fever DisGeNET BeFree 2.614E-4 4.471E-3 3.073E-2
1.417E-1
 2 58
28 C0206638 Giant Cell Tumor of Bone DisGeNET Curated 2.797E-4 4.471E-3 3.073E-2
1.516E-1
 2 60
29 C0848332 Spots on skin DisGeNET BeFree 2.907E-4 4.471E-3 3.073E-2
1.575E-1
 3 336
30 C1332977 Childhood Leukemia DisGeNET BeFree 3.809E-4 4.471E-3 3.073E-2
2.064E-1
 2 70
31 C0949690 Spondylarthritis DisGeNET Curated 3.809E-4 4.471E-3 3.073E-2
2.064E-1
 2 70
32 C0005967 Bone neoplasms DisGeNET Curated 4.030E-4 4.471E-3 3.073E-2
2.184E-1
 2 72
33 C0029456 Osteoporosis DisGeNET Curated 4.047E-4 4.471E-3 3.073E-2
2.193E-1
 3 376
34 cv:C0008928 Cleidocranial dysostosis Clinical Variations 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
35 C3804986 Paranasal sinus aplasia DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
36 C1834969 Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly DisGeNET BeFree 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
37 cv:C1832388 Familial platelet disorder with associated myeloid malignancy Clinical Variations 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
38 C1857131 Absent paranasal sinuses DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
39 OMIN:119600 CLEIDOCRANIAL DYSPLASIA; CCD OMIM 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
40 cv:C1834969 Metaphyseal dysplasia with maxillary hypoplasia and brachydactyly Clinical Variations 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
41 C0243057 Stomatognathic System Abnormalities DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
42 C0279550 adult rhabdomyosarcoma DisGeNET BeFree 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
43 C1333117 Colorectal Tubular Adenoma DisGeNET BeFree 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
44 OMIN:601399 PLATELET DISORDER, FAMILIAL, WITH ASSOCIATED MYELOID MALIGNANCY OMIM 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
45 C4072844 Missing sinuses DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
46 C0686761 Lack of bone formation DisGeNET BeFree 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
47 C3164096 Sarcoma of mesentery DisGeNET BeFree 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
48 C1861517 Abnormal facility in opposing the shoulders DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
49 C3549874 METAPHYSEAL DYSPLASIA WITH MAXILLARY HYPOPLASIA WITH OR WITHOUT BRACHYDACTYLY DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
50 C1861531 Long second metacarpal DisGeNET Curated 4.320E-4 4.471E-3 3.073E-2
2.341E-1
 1 1
Show 45 more annotations