Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc185_40, positive side

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1: GO: Molecular Function [Display Chart] 40 input genes in category / 161 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0004674 protein serine/threonine kinase activity 1.064E-14 1.713E-12 9.698E-12 1.713E-12 15 452
2 GO:0004708 MAP kinase kinase activity 2.484E-12 1.999E-10 1.132E-9 3.999E-10 6 20
3 GO:0004707 MAP kinase activity 6.929E-10 3.029E-8 1.715E-7 1.115E-7 5 21
4 GO:0004712 protein serine/threonine/tyrosine kinase activity 7.526E-10 3.029E-8 1.715E-7 1.212E-7 6 48
5 GO:0004713 protein tyrosine kinase activity 4.134E-9 1.331E-7 7.536E-7 6.655E-7 8 182
6 GO:0030296 protein tyrosine kinase activator activity 7.281E-6 1.954E-4 1.106E-3 1.172E-3 3 18
7 GO:0031435 mitogen-activated protein kinase kinase kinase binding 1.568E-5 3.607E-4 2.042E-3 2.525E-3 3 23
8 GO:0019209 kinase activator activity 3.385E-5 6.813E-4 3.857E-3 5.450E-3 4 86
9 GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific 4.167E-5 7.454E-4 4.220E-3 6.709E-3 5 182
10 GO:0030546 receptor activator activity 5.694E-5 9.167E-4 5.190E-3 9.167E-3 3 35
11 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity 9.344E-5 1.368E-3 7.743E-3 1.504E-2 2 7
12 GO:0000982 transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding 1.176E-4 1.578E-3 8.933E-3 1.893E-2 6 365
13 GO:0008545 JUN kinase kinase activity 1.598E-4 1.978E-3 1.120E-2 2.572E-2 2 9
14 GO:0030545 receptor regulator activity 1.769E-4 2.007E-3 1.136E-2 2.848E-2 3 51
15 GO:0016909 SAP kinase activity 1.994E-4 2.007E-3 1.136E-2 3.211E-2 2 10
16 GO:0004705 JUN kinase activity 1.994E-4 2.007E-3 1.136E-2 3.211E-2 2 10
17 GO:0046934 phosphatidylinositol-4,5-bisphosphate 3-kinase activity 3.161E-4 2.994E-3 1.695E-2
5.089E-2
 3 62
18 GO:0005085 guanyl-nucleotide exchange factor activity 4.717E-4 4.162E-3 2.356E-2
7.594E-2
 5 306
19 GO:0052813 phosphatidylinositol bisphosphate kinase activity 4.911E-4 4.162E-3 2.356E-2
7.907E-2
 3 72
20 GO:0035004 phosphatidylinositol 3-kinase activity 5.979E-4 4.760E-3 2.695E-2
9.627E-2
 3 77
21 GO:0030295 protein kinase activator activity 6.209E-4 4.760E-3 2.695E-2
9.997E-2
 3 78
22 GO:0001158 enhancer sequence-specific DNA binding 1.036E-3 7.581E-3 4.292E-2
1.668E-1
 3 93
23 GO:0019207 kinase regulator activity 1.151E-3 8.057E-3 4.562E-2
1.853E-1
 4 216
24 GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding 1.234E-3 8.280E-3 4.688E-2
1.987E-1
 5 379
25 GO:0005088 Ras guanyl-nucleotide exchange factor activity 1.498E-3 9.136E-3
5.173E-2
2.411E-1
 4 232
26 GO:0035326 enhancer binding 1.511E-3 9.136E-3
5.173E-2
2.432E-1
 3 106
27 GO:0000987 proximal promoter sequence-specific DNA binding 1.532E-3 9.136E-3
5.173E-2
2.467E-1
 5 398
28 GO:0001078 proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific 1.861E-3 1.070E-2
6.058E-2
2.996E-1
 3 114
29 GO:0001085 RNA polymerase II transcription factor binding 2.053E-3 1.140E-2
6.454E-2
3.306E-1
 3 118
30 GO:0001225 RNA polymerase II transcription coactivator binding 2.144E-3 1.150E-2
6.513E-2
3.451E-1
 1 1
31 GO:0001077 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific 2.238E-3 1.162E-2
6.580E-2
3.603E-1
 4 259
32 GO:0019903 protein phosphatase binding 3.469E-3 1.745E-2
9.881E-2
5.585E-1
 3 142
33 GO:0003713 transcription coactivator activity 4.263E-3 2.028E-2
1.148E-1
6.864E-1
 4 310
34 GO:0038131 neuregulin receptor activity 4.283E-3 2.028E-2
1.148E-1
6.895E-1
 1 2
35 GO:0051018 protein kinase A binding 4.556E-3 2.096E-2
1.187E-1
7.336E-1
 2 47
36 GO:0001047 core promoter binding 5.188E-3 2.320E-2
1.314E-1
8.352E-1
 3 164
37 GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific 6.995E-3 3.044E-2
1.723E-1
1.000E0
 4 357
38 GO:0019902 phosphatase binding 7.452E-3 3.157E-2
1.788E-1
1.000E0
 3 187
39 GO:0019887 protein kinase regulator activity 8.356E-3 3.276E-2
1.855E-1
1.000E0
 3 195
40 GO:0001224 RNA polymerase II transcription cofactor binding 8.547E-3 3.276E-2
1.855E-1
1.000E0
 1 4
41 GO:0019834 phospholipase A2 inhibitor activity 8.547E-3 3.276E-2
1.855E-1
1.000E0
 1 4
42 GO:0005176 ErbB-2 class receptor binding 8.547E-3 3.276E-2
1.855E-1
1.000E0
 1 4
43 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding 8.812E-3 3.300E-2
1.868E-1
1.000E0
 2 66
44 GO:0050839 cell adhesion molecule binding 9.959E-3 3.628E-2
2.054E-1
1.000E0
 3 208
45 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding 1.014E-2 3.628E-2
2.054E-1
1.000E0
 2 71
46 GO:0043125 ErbB-3 class receptor binding 1.067E-2 3.656E-2
2.070E-1
1.000E0
 1 5
47 GO:0051525 NFAT protein binding 1.067E-2 3.656E-2
2.070E-1
1.000E0
 1 5
48 GO:0046332 SMAD binding 1.184E-2 3.973E-2
2.249E-1
1.000E0
 2 77
49 GO:0038132 neuregulin binding 1.279E-2 4.120E-2
2.332E-1
1.000E0
 1 6
50 GO:0048273 mitogen-activated protein kinase p38 binding 1.279E-2 4.120E-2
2.332E-1
1.000E0
 1 6
Show 45 more annotations

2: GO: Biological Process [Display Chart] 40 input genes in category / 1805 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043405 regulation of MAP kinase activity 5.857E-21 1.057E-17 8.537E-17 1.057E-17 18 356
2 GO:0032147 activation of protein kinase activity 3.251E-20 2.934E-17 2.370E-16 5.869E-17 17 316
3 GO:0071902 positive regulation of protein serine/threonine kinase activity 1.809E-18 9.985E-16 8.064E-15 3.264E-15 16 321
4 GO:0045860 positive regulation of protein kinase activity 2.213E-18 9.985E-16 8.064E-15 3.994E-15 18 496
5 GO:0000187 activation of MAPK activity 6.486E-18 2.341E-15 1.891E-14 1.171E-14 13 157
6 GO:0043406 positive regulation of MAP kinase activity 1.110E-15 3.340E-13 2.697E-12 2.004E-12 13 232
7 GO:0051403 stress-activated MAPK cascade 8.378E-12 2.160E-9 1.745E-8 1.512E-8 11 272
8 GO:0031098 stress-activated protein kinase signaling cascade 1.061E-11 2.393E-9 1.932E-8 1.914E-8 11 278
9 GO:0033173 calcineurin-NFAT signaling cascade 1.479E-11 2.967E-9 2.396E-8 2.670E-8 6 26
10 GO:0048016 inositol phosphate-mediated signaling 1.468E-10 2.650E-8 2.140E-7 2.650E-7 6 37
11 GO:0035897 proteolysis in other organism 2.728E-10 4.476E-8 3.615E-7 4.924E-7 4 6
12 GO:0007254 JNK cascade 6.437E-10 9.682E-8 7.819E-7 1.162E-6 9 216
13 GO:0038066 p38MAPK cascade 9.378E-9 1.302E-6 1.052E-5 1.693E-5 5 34
14 GO:0038095 Fc-epsilon receptor signaling pathway 1.951E-8 2.516E-6 2.032E-5 3.522E-5 7 142
15 GO:0051149 positive regulation of muscle cell differentiation 5.012E-8 6.031E-6 4.871E-5 9.047E-5 6 95
16 GO:0046328 regulation of JNK cascade 1.118E-7 1.261E-5 1.019E-4 2.018E-4 7 183
17 GO:0000186 activation of MAPKK activity 1.361E-7 1.445E-5 1.167E-4 2.457E-4 5 57
18 GO:0042692 muscle cell differentiation 1.733E-7 1.679E-5 1.356E-4 3.128E-4 9 412
19 GO:0051155 positive regulation of striated muscle cell differentiation 1.767E-7 1.679E-5 1.356E-4 3.190E-4 5 60
20 GO:0038093 Fc receptor signaling pathway 2.503E-7 2.259E-5 1.825E-4 4.519E-4 7 206
21 GO:0055024 regulation of cardiac muscle tissue development 2.652E-7 2.279E-5 1.841E-4 4.786E-4 5 65
22 GO:0048738 cardiac muscle tissue development 3.345E-7 2.744E-5 2.216E-4 6.037E-4 7 215
23 GO:0046330 positive regulation of JNK cascade 3.725E-7 2.924E-5 2.361E-4 6.724E-4 6 133
24 GO:0032872 regulation of stress-activated MAPK cascade 4.153E-7 3.091E-5 2.496E-4 7.496E-4 7 222
25 GO:0070302 regulation of stress-activated protein kinase signaling cascade 4.281E-7 3.091E-5 2.496E-4 7.727E-4 7 223
26 GO:0055017 cardiac muscle tissue growth 5.455E-7 3.787E-5 3.058E-4 9.845E-4 5 75
27 GO:0060043 regulation of cardiac muscle cell proliferation 8.076E-7 5.399E-5 4.360E-4 1.458E-3 4 34
28 GO:0032874 positive regulation of stress-activated MAPK cascade 8.825E-7 5.689E-5 4.594E-4 1.593E-3 6 154
29 GO:0070304 positive regulation of stress-activated protein kinase signaling cascade 9.166E-7 5.705E-5 4.607E-4 1.654E-3 6 155
30 GO:0060419 heart growth 9.620E-7 5.788E-5 4.674E-4 1.736E-3 5 84
31 GO:0019722 calcium-mediated signaling 1.230E-6 7.163E-5 5.785E-4 2.220E-3 6 163
32 GO:0055025 positive regulation of cardiac muscle tissue development 1.277E-6 7.206E-5 5.819E-4 2.306E-3 4 38
33 GO:0018108 peptidyl-tyrosine phosphorylation 1.338E-6 7.317E-5 5.909E-4 2.415E-3 8 385
34 GO:0018212 peptidyl-tyrosine modification 1.391E-6 7.330E-5 5.919E-4 2.510E-3 8 387
35 GO:0038128 ERBB2 signaling pathway 1.421E-6 7.330E-5 5.919E-4 2.565E-3 4 39
36 GO:2001223 negative regulation of neuron migration 1.497E-6 7.504E-5 6.060E-4 2.702E-3 3 11
37 GO:0014706 striated muscle tissue development 1.682E-6 7.993E-5 6.455E-4 3.037E-3 8 397
38 GO:0051147 regulation of muscle cell differentiation 1.683E-6 7.993E-5 6.455E-4 3.037E-3 6 172
39 GO:0000185 activation of MAPKKK activity 1.993E-6 9.222E-5 7.448E-4 3.597E-3 3 12
40 GO:0051153 regulation of striated muscle cell differentiation 2.288E-6 1.030E-4 8.320E-4 4.130E-3 5 100
41 GO:0060537 muscle tissue development 2.340E-6 1.030E-4 8.320E-4 4.224E-3 8 415
42 GO:0051146 striated muscle cell differentiation 2.424E-6 1.042E-4 8.411E-4 4.375E-3 7 289
43 GO:0033002 muscle cell proliferation 2.734E-6 1.148E-4 9.268E-4 4.935E-3 6 187
44 GO:0060038 cardiac muscle cell proliferation 3.044E-6 1.249E-4 1.008E-3 5.495E-3 4 47
45 GO:0070935 3'-UTR-mediated mRNA stabilization 3.287E-6 1.318E-4 1.065E-3 5.933E-3 3 14
46 GO:0055021 regulation of cardiac muscle tissue growth 3.605E-6 1.415E-4 1.142E-3 6.507E-3 4 49
47 GO:0071214 cellular response to abiotic stimulus 3.691E-6 1.417E-4 1.145E-3 6.662E-3 7 308
48 GO:0072708 response to sorbitol 4.498E-6 1.657E-4 1.338E-3 8.119E-3 2 2
49 GO:0072709 cellular response to sorbitol 4.498E-6 1.657E-4 1.338E-3 8.119E-3 2 2
50 GO:1900745 positive regulation of p38MAPK cascade 5.042E-6 1.820E-4 1.470E-3 9.101E-3 3 16
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 40 input genes in category / 128 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex 1.286E-5 1.647E-3 8.947E-3 1.647E-3 2 3
2 GO:0005667 transcription factor complex 1.096E-4 3.806E-3 2.068E-2 1.403E-2 6 368
3 GO:0099572 postsynaptic specialization 1.189E-4 3.806E-3 2.068E-2 1.522E-2 5 232
4 GO:0014069 postsynaptic density 1.189E-4 3.806E-3 2.068E-2 1.522E-2 5 232
5 GO:0060076 excitatory synapse 1.750E-4 4.481E-3 2.434E-2 2.240E-2 5 252
6 GO:0098794 postsynapse 3.216E-4 6.860E-3 3.727E-2 4.116E-2 6 449
7 GO:0031252 cell leading edge 1.262E-3 2.307E-2
1.253E-1
1.615E-1
 5 389
8 GO:0043204 perikaryon 3.269E-3 4.472E-2
2.430E-1
4.184E-1
 3 142
9 GO:0097060 synaptic membrane 3.436E-3 4.472E-2
2.430E-1
4.398E-1
 4 298
10 GO:0043197 dendritic spine 3.885E-3 4.472E-2
2.430E-1
4.973E-1
 3 151
11 GO:0044309 neuron spine 4.031E-3 4.472E-2
2.430E-1
5.159E-1
 3 153
12 GO:1990667 PCSK9-AnxA2 complex 4.193E-3 4.472E-2
2.430E-1
5.367E-1
 1 2
13 GO:0032589 neuron projection membrane 4.745E-3 4.672E-2
2.538E-1
6.073E-1
 2 49
Show 8 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 643 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 36 input genes in category / 1318 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0008088 abnormal T-helper 1 cell differentiation 8.417E-8 1.109E-4 8.610E-4 1.109E-4 5 33
2 MP:0008076 abnormal CD4-positive T cell differentiation 7.450E-7 4.909E-4 3.810E-3 9.819E-4 6 94
3 MP:0002433 abnormal T-helper 1 cell morphology 1.527E-6 6.707E-4 5.205E-3 2.012E-3 5 58
4 MP:0010183 abnormal CD4-positive helper T cell morphology 3.449E-6 1.014E-3 7.867E-3 4.545E-3 6 122
5 MP:0005329 abnormal myocardium layer morphology 3.915E-6 1.014E-3 7.867E-3 5.160E-3 10 485
6 MP:0010545 abnormal heart layer morphology 4.614E-6 1.014E-3 7.867E-3 6.082E-3 10 494
7 MP:0013760 abnormal T-helper cell morphology 8.646E-6 1.628E-3 1.263E-2 1.140E-2 6 143
8 MP:0002145 abnormal T cell differentiation 1.084E-5 1.787E-3 1.387E-2 1.429E-2 9 426
9 MP:0002189 abnormal myocardial trabeculae morphology 1.644E-5 2.408E-3 1.869E-2 2.167E-2 6 160
10 MP:0004796 increased anti-histone antibody level 2.095E-5 2.633E-3 2.044E-2 2.761E-2 3 16
11 MP:0006043 decreased apoptosis 2.410E-5 2.633E-3 2.044E-2 3.177E-2 7 257
12 MP:0005463 abnormal CD4-positive, alpha-beta T cell physiology 2.479E-5 2.633E-3 2.044E-2 3.268E-2 6 172
13 MP:0012555 decreased cell death 2.597E-5 2.633E-3 2.044E-2 3.423E-2 7 260
14 MP:0002995 primary sex reversal 3.599E-5 3.389E-3 2.630E-2 4.744E-2 3 19
15 MP:0005465 abnormal T-helper 1 physiology 3.973E-5 3.491E-3 2.710E-2
5.237E-2
 4 56
16 MP:0003567 abnormal fetal cardiomyocyte proliferation 4.887E-5 4.026E-3 3.124E-2
6.441E-2
 4 59
17 MP:0011390 abnormal fetal cardiomyocyte physiology 7.606E-5 5.897E-3 4.577E-2
1.002E-1
 4 66
18 MP:0002493 increased IgG level 1.139E-4 8.095E-3
6.283E-2
1.501E-1
 6 226
19 MP:0008092 abnormal T-helper 2 cell differentiation 1.191E-4 8.095E-3
6.283E-2
1.570E-1
 3 28
20 MP:0005094 abnormal T cell proliferation 1.394E-4 8.095E-3
6.283E-2
1.837E-1
 7 339
21 MP:0005652 sex reversal 1.469E-4 8.095E-3
6.283E-2
1.936E-1
 3 30
22 MP:0003038 decreased myocardial infarction size 1.469E-4 8.095E-3
6.283E-2
1.936E-1
 3 30
23 MP:0010298 increased respiratory system tumor incidence 1.517E-4 8.095E-3
6.283E-2
2.000E-1
 5 149
24 MP:0008014 increased lung tumor incidence 1.517E-4 8.095E-3
6.283E-2
2.000E-1
 5 149
25 MP:0008700 decreased interleukin-4 secretion 1.535E-4 8.095E-3
6.283E-2
2.024E-1
 4 79
26 MP:0003204 decreased neuron apoptosis 1.774E-4 8.994E-3
6.981E-2
2.338E-1
 4 82
27 MP:0011818 abnormal pancreatic beta cell proliferation 2.340E-4 1.142E-2
8.866E-2
3.084E-1
 3 35
28 MP:0001176 abnormal lung development 2.514E-4 1.183E-2
9.183E-2
3.313E-1
 5 166
29 MP:0001828 abnormal T cell activation 2.772E-4 1.260E-2
9.777E-2
3.653E-1
 7 379
30 MP:0008567 decreased interferon-gamma secretion 3.044E-4 1.337E-2
1.038E-1
4.012E-1
 5 173
31 MP:0010949 decreased Clara cell number 3.248E-4 1.341E-2
1.041E-1
4.280E-1
 2 8
32 MP:0008499 increased IgG1 level 3.255E-4 1.341E-2
1.041E-1
4.290E-1
 4 96
33 MP:0008559 abnormal interferon-gamma secretion 3.440E-4 1.374E-2
1.066E-1
4.533E-1
 6 277
34 MP:0002407 abnormal double-negative T cell morphology 3.750E-4 1.454E-2
1.128E-1
4.943E-1
 5 181
35 MP:0000267 abnormal heart development 3.907E-4 1.471E-2
1.142E-1
5.149E-1
 7 401
36 MP:0013561 abnormal endocrine gland physiology 4.026E-4 1.474E-2
1.144E-1
5.306E-1
 7 403
37 MP:0020174 abnormal IgG level 4.533E-4 1.543E-2
1.198E-1
5.975E-1
 7 411
38 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis 4.581E-4 1.543E-2
1.198E-1
6.038E-1
 4 105
39 MP:0003306 small intestinal inflammation 4.634E-4 1.543E-2
1.198E-1
6.108E-1
 3 44
40 MP:0000297 abnormal atrioventricular cushion morphology 4.749E-4 1.543E-2
1.198E-1
6.259E-1
 4 106
41 MP:0003115 abnormal respiratory system development 4.800E-4 1.543E-2
1.198E-1
6.326E-1
 5 191
42 MP:0008660 increased interleukin-10 secretion 4.954E-4 1.554E-2
1.207E-1
6.529E-1
 3 45
43 MP:0001844 autoimmune response 5.090E-4 1.560E-2
1.211E-1
6.709E-1
 7 419
44 MP:0005005 abnormal self tolerance 5.238E-4 1.569E-2
1.218E-1
6.904E-1
 7 421
45 MP:0000260 abnormal angiogenesis 5.543E-4 1.620E-2
1.258E-1
7.306E-1
 7 425
46 MP:0006107 abnormal fetal atrioventricular canal morphology 5.655E-4 1.620E-2
1.258E-1
7.454E-1
 4 111
47 MP:0005000 abnormal immune tolerance 5.863E-4 1.644E-2
1.276E-1
7.727E-1
 7 429
48 MP:0005090 increased double-negative T cell number 6.464E-4 1.775E-2
1.378E-1
8.520E-1
 4 115
49 MP:0002693 abnormal pancreas physiology 6.807E-4 1.825E-2
1.416E-1
8.972E-1
 6 315
50 MP:0003562 abnormal pancreatic beta cell physiology 6.923E-4 1.825E-2
1.416E-1
9.125E-1
 5 207
Show 45 more annotations

6: Domain [Display Chart] 40 input genes in category / 231 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR008271 Ser/Thr kinase AS InterPro 3.091E-16 2.752E-14 1.657E-13 7.141E-14 15 357
2 SM00220 S TKc SMART 3.359E-16 2.752E-14 1.657E-13 7.758E-14 15 359
3 PS00108 PROTEIN KINASE ST PROSITE 3.800E-16 2.752E-14 1.657E-13 8.778E-14 15 362
4 PS00107 PROTEIN KINASE ATP PROSITE 4.765E-16 2.752E-14 1.657E-13 1.101E-13 16 459
5 PF00069 Pkinase Pfam 8.109E-16 3.746E-14 2.256E-13 1.873E-13 15 381
6 IPR000719 Prot kinase dom InterPro 1.286E-15 4.819E-14 2.902E-13 2.970E-13 16 489
7 PS50011 PROTEIN KINASE DOM PROSITE 1.460E-15 4.819E-14 2.902E-13 3.373E-13 16 493
8 IPR003527 MAP kinase CS InterPro 2.681E-11 6.882E-10 4.144E-9 6.194E-9 5 12
9 PS01351 MAPK PROSITE 2.681E-11 6.882E-10 4.144E-9 6.194E-9 5 12
10 IPR008366 NFAT InterPro 8.891E-11 2.054E-9 1.237E-8 2.054E-8 4 5
11 IPR017441 Protein kinase ATP BS InterPro 2.746E-10 5.767E-9 3.473E-8 6.344E-8 11 379
12 PS50254 REL 2 PROSITE 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
13 PF16179 RHD dimer Pfam 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
14 IPR011539 RHD DNA bind dom InterPro 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
15 PF00554 RHD DNA bind Pfam 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
16 IPR000451 NFkB/Dor InterPro 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
17 PS01204 REL 1 PROSITE 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
18 2.60.40.340 - Gene3D 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
19 IPR032397 RHD dimer InterPro 3.705E-9 4.505E-8 2.713E-7 8.560E-7 4 10
20 PF01833 TIG Pfam 5.585E-9 6.450E-8 3.884E-7 1.290E-6 5 31
21 IPR002909 IPT InterPro 6.609E-9 7.269E-8 4.378E-7 1.527E-6 5 32
22 IPR024824 GADD45 InterPro 9.016E-9 9.467E-8 5.701E-7 2.083E-6 3 3
23 IPR008352 MAPK p38 InterPro 3.601E-8 3.617E-7 2.178E-6 8.318E-6 3 4
24 IPR008351 MAPK JNK InterPro 8.989E-8 8.422E-7 5.071E-6 2.077E-5 3 5
25 IPR008967 p53-like TF DNA-bd InterPro 9.114E-8 8.422E-7 5.071E-6 2.105E-5 5 53
26 SM00429 IPT SMART 3.017E-7 2.680E-6 1.614E-5 6.969E-5 4 27
27 PF01248 Ribosomal L7Ae Pfam 1.470E-6 1.258E-5 7.574E-5 3.396E-4 3 11
28 IPR004038 Ribosomal L7Ae/L30e/S12e/Gad45 InterPro 1.957E-6 1.615E-5 9.724E-5 4.521E-4 3 12
29 IPR014756 Ig E-set InterPro 2.698E-6 2.149E-5 1.294E-4 6.231E-4 5 104
30 IPR029064 L30e-like InterPro 4.030E-6 3.003E-5 1.808E-4 9.309E-4 3 15
31 3.30.1330.30 - Gene3D 4.030E-6 3.003E-5 1.808E-4 9.309E-4 3 15
32 IPR015646 NFAT5 InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
33 IPR015647 NFAT1 InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
34 PF02731 SKIP SNW Pfam 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
35 PS50830 TNASE 3 PROSITE 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
36 IPR002389 AnnexinII InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
37 IPR022331 Notch 3 InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
38 PF00565 SNase Pfam 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
39 PS01284 TNASE 2 PROSITE 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
40 IPR016685 Silence cplx Nase-comp TudorSN InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
41 IPR015019 LAMTOR3 InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
42 PF08923 MAPKK1 Int Pfam 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
43 IPR017862 SKI-int prot SKIP InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
44 IPR004015 SKI-int prot SKIP SNW-dom InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
45 SM00318 SNc SMART 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
46 IPR018250 NRG1 InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
47 SM01278 MAPKK1 Int SMART 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
48 IPR016317 Pro-epidermal GF InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
49 IPR033573 GSK3B InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
50 IPR002071 Thermonucl AS InterPro 2.135E-3 9.864E-3
5.940E-2
4.932E-1
 1 1
Show 45 more annotations

7: Pathway [Display Chart] 39 input genes in category / 786 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 83048 MAPK signaling pathway BioSystems: KEGG 9.374E-21 7.368E-18 5.338E-17 7.368E-18 18 255
2 M13863 MAPKinase Signaling Pathway MSigDB C2 BIOCARTA (v6.0) 1.443E-15 5.673E-13 4.110E-12 1.135E-12 11 87
3 1269211 MAP kinase activation in TLR cascade BioSystems: REACTOME 3.495E-15 9.157E-13 6.634E-12 2.747E-12 10 64
4 P04393 Ras Pathway PantherDB 6.652E-15 1.307E-12 9.469E-12 5.228E-12 10 68
5 585562 Epstein-Barr virus infection BioSystems: KEGG 2.192E-14 3.446E-12 2.497E-11 1.723E-11 13 203
6 1269207 MyD88 cascade initiated on plasma membrane BioSystems: REACTOME 6.105E-14 5.998E-12 4.345E-11 4.798E-11 10 84
7 1269226 Toll Like Receptor 5 (TLR5) Cascade BioSystems: REACTOME 6.105E-14 5.998E-12 4.345E-11 4.798E-11 10 84
8 1269206 Toll Like Receptor 10 (TLR10) Cascade BioSystems: REACTOME 6.105E-14 5.998E-12 4.345E-11 4.798E-11 10 84
9 1270428 Oxidative Stress Induced Senescence BioSystems: REACTOME 1.055E-13 9.214E-12 6.676E-11 8.293E-11 11 127
10 1269229 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation BioSystems: REACTOME 1.400E-13 9.530E-12 6.905E-11 1.100E-10 10 91
11 M12012 p38 MAPK Pathway MSigDB C2 BIOCARTA (v6.0) 1.559E-13 9.530E-12 6.905E-11 1.226E-10 8 37
12 1458885 Th1 and Th2 cell differentiation BioSystems: KEGG 1.567E-13 9.530E-12 6.905E-11 1.232E-10 10 92
13 1269228 MyD88 dependent cascade initiated on endosome BioSystems: REACTOME 1.752E-13 9.530E-12 6.905E-11 1.377E-10 10 93
14 1269227 Toll Like Receptor 7/8 (TLR7/8) Cascade BioSystems: REACTOME 1.752E-13 9.530E-12 6.905E-11 1.377E-10 10 93
15 1269240 Toll Like Receptor TLR6:TLR2 Cascade BioSystems: REACTOME 2.183E-13 9.530E-12 6.905E-11 1.715E-10 10 95
16 1269237 MyD88:Mal cascade initiated on plasma membrane BioSystems: REACTOME 2.183E-13 9.530E-12 6.905E-11 1.715E-10 10 95
17 1269238 Toll Like Receptor 2 (TLR2) Cascade BioSystems: REACTOME 2.183E-13 9.530E-12 6.905E-11 1.715E-10 10 95
18 1269239 Toll Like Receptor TLR1:TLR2 Cascade BioSystems: REACTOME 2.183E-13 9.530E-12 6.905E-11 1.715E-10 10 95
19 1269233 Toll Like Receptor 9 (TLR9) Cascade BioSystems: REACTOME 2.705E-13 1.119E-11 8.106E-11 2.126E-10 10 97
20 1269220 MyD88-independent TLR3/TLR4 cascade BioSystems: REACTOME 3.336E-13 1.192E-11 8.636E-11 2.622E-10 10 99
21 1269219 Toll Like Receptor 3 (TLR3) Cascade BioSystems: REACTOME 3.336E-13 1.192E-11 8.636E-11 2.622E-10 10 99
22 1269221 TRIF-mediated TLR3/TLR4 signaling BioSystems: REACTOME 3.336E-13 1.192E-11 8.636E-11 2.622E-10 10 99
23 83082 Fc epsilon RI signaling pathway BioSystems: KEGG 4.651E-13 1.590E-11 1.152E-10 3.656E-10 9 68
24 P00018 EGF receptor signaling pathway PantherDB 1.076E-12 3.523E-11 2.553E-10 8.456E-10 10 111
25 1269236 Activated TLR4 signalling BioSystems: REACTOME 1.543E-12 4.850E-11 3.514E-10 1.213E-9 10 115
26 137943 p38 MAPK signaling pathway BioSystems: Pathway Interaction Database 2.488E-12 7.520E-11 5.448E-10 1.955E-9 7 29
27 1269234 Toll Like Receptor 4 (TLR4) Cascade BioSystems: REACTOME 3.895E-12 1.134E-10 8.214E-10 3.061E-9 10 126
28 P00010 B cell activation PantherDB 7.389E-12 2.074E-10 1.503E-9 5.807E-9 8 58
29 83091 GnRH signaling pathway BioSystems: KEGG 7.782E-12 2.109E-10 1.528E-9 6.116E-9 9 92
30 M12705 Genes related to CD40 signaling MSigDB C2 BIOCARTA (v6.0) 8.478E-12 2.221E-10 1.609E-9 6.664E-9 7 34
31 MAP kinase kinase activity MAP kinase kinase activity GenMAPP 1.286E-11 3.193E-10 2.313E-9 1.011E-8 5 8
32 P05918 p38 MAPK pathway PantherDB 1.310E-11 3.193E-10 2.313E-9 1.029E-8 7 36
33 1270426 Cellular Senescence BioSystems: REACTOME 1.340E-11 3.193E-10 2.313E-9 1.054E-8 11 197
34 83076 Toll-like receptor signaling pathway BioSystems: KEGG 2.397E-11 5.542E-10 4.015E-9 1.884E-8 9 104
35 1269204 Toll-Like Receptors Cascades BioSystems: REACTOME 2.737E-11 6.147E-10 4.454E-9 2.152E-8 10 153
36 812256 TNF signaling pathway BioSystems: KEGG 3.383E-11 7.387E-10 5.352E-9 2.659E-8 9 108
37 PW:0000198 p38 MAPK signaling Pathway Ontology 4.544E-11 9.652E-10 6.993E-9 3.571E-8 6 22
38 101143 Neurotrophin signaling pathway BioSystems: KEGG 8.168E-11 1.655E-9 1.199E-8 6.420E-8 9 119
39 M19118 Keratinocyte Differentiation MSigDB C2 BIOCARTA (v6.0) 8.210E-11 1.655E-9 1.199E-8 6.453E-8 7 46
40 217173 Influenza A BioSystems: KEGG 9.283E-11 1.824E-9 1.321E-8 7.296E-8 10 173
41 193147 Osteoclast differentiation BioSystems: KEGG 1.815E-10 3.480E-9 2.521E-8 1.427E-7 9 130
42 83049 ErbB signaling pathway BioSystems: KEGG 1.922E-10 3.597E-9 2.606E-8 1.511E-7 8 86
43 921162 FoxO signaling pathway BioSystems: KEGG 2.082E-10 3.806E-9 2.758E-8 1.637E-7 9 132
44 1474302 Fluid shear stress and atherosclerosis BioSystems: KEGG 4.011E-10 7.164E-9 5.190E-8 3.152E-7 9 142
45 1270414 Cellular responses to stress BioSystems: REACTOME 5.809E-10 1.015E-8 7.351E-8 4.566E-7 13 454
46 83080 T cell receptor signaling pathway BioSystems: KEGG 8.292E-10 1.417E-8 1.026E-7 6.518E-7 8 103
47 138081 FAS (CD95) signaling pathway BioSystems: Pathway Interaction Database 9.596E-10 1.605E-8 1.163E-7 7.543E-7 6 35
48 1269298 Fc epsilon receptor (FCERI) signaling BioSystems: REACTOME 1.053E-9 1.724E-8 1.249E-7 8.277E-7 12 381
49 M10287 fMLP induced chemokine gene expression in HMC-1 cells MSigDB C2 BIOCARTA (v6.0) 1.368E-9 2.195E-8 1.590E-7 1.075E-6 6 37
50 137994 CDC42 signaling events BioSystems: Pathway Interaction Database 1.742E-9 2.738E-8 1.984E-7 1.369E-6 7 70
Show 45 more annotations

8: Pubmed [Display Chart] 40 input genes in category / 12650 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 25241761 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. Pubmed 9.623E-19 1.217E-14 1.220E-13 1.217E-14 14 371
2 15276183 MD-2: the Toll 'gatekeeper' in endotoxin signalling. Pubmed 6.053E-17 3.829E-13 3.837E-12 7.657E-13 9 74
3 15767678 Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Pubmed 1.337E-16 5.639E-13 5.652E-12 1.692E-12 7 22
4 22154358 Stress-activated kinase pathway alteration is a frequent event in bladder cancer. Pubmed 5.827E-15 1.843E-11 1.847E-10 7.371E-11 5 6
5 11062067 Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7. Pubmed 2.038E-14 5.156E-11 5.167E-10 2.578E-10 5 7
6 20805296 Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients. Pubmed 7.656E-13 1.251E-9 1.254E-8 9.685E-9 5 12
7 12171600 Stress-induced regulation of eukaryotic elongation factor 2 kinase by SB 203580-sensitive and -insensitive pathways. Pubmed 7.656E-13 1.251E-9 1.254E-8 9.685E-9 5 12
8 23300479 Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice. Pubmed 7.913E-13 1.251E-9 1.254E-8 1.001E-8 6 32
9 12893778 Mechanism of p38 MAP kinase activation in vivo. Pubmed 1.031E-12 1.304E-9 1.307E-8 1.304E-8 4 4
10 9768359 Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2. Pubmed 1.031E-12 1.304E-9 1.307E-8 1.304E-8 4 4
11 12239168 gp120-mediated induction of the MAPK cascade is dependent on the activation state of CD4(+) lymphocytes. Pubmed 1.932E-12 2.222E-9 2.227E-8 2.444E-8 5 14
12 11877454 NFAT: ubiquitous regulator of cell differentiation and adaptation. Pubmed 5.151E-12 5.012E-9 5.024E-8 6.516E-8 4 5
13 19302196 The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. Pubmed 5.151E-12 5.012E-9 5.024E-8 6.516E-8 4 5
14 18757346 LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase. Pubmed 1.544E-11 1.028E-8 1.030E-7 1.953E-7 4 6
15 9841871 Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades. Pubmed 1.544E-11 1.028E-8 1.030E-7 1.953E-7 4 6
16 17214902 Mouse preimplantation embryo responses to culture medium osmolarity include increased expression of CCM2 and p38 MAPK activation. Pubmed 1.544E-11 1.028E-8 1.030E-7 1.953E-7 4 6
17 25728138 The lncRNA NRON modulates HIV-1 replication in a NFAT-dependent manner and is differentially regulated by early and late viral proteins. Pubmed 1.544E-11 1.028E-8 1.030E-7 1.953E-7 4 6
18 16141075 A strategy for probing the function of noncoding RNAs finds a repressor of NFAT. Pubmed 1.544E-11 1.028E-8 1.030E-7 1.953E-7 4 6
19 12370307 Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth. Pubmed 1.544E-11 1.028E-8 1.030E-7 1.953E-7 4 6
20 10878576 p38 MAPK signalling cascades: ancient roles and new functions. Pubmed 3.600E-11 2.169E-8 2.174E-7 4.554E-7 4 7
21 12189133 Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade. Pubmed 3.600E-11 2.169E-8 2.174E-7 4.554E-7 4 7
22 12761180 Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN. Pubmed 7.195E-11 3.957E-8 3.966E-7 9.102E-7 4 8
23 11359773 A Novel MAPK phosphatase MKP-7 acts preferentially on JNK/SAPK and p38 alpha and beta MAPKs. Pubmed 7.195E-11 3.957E-8 3.966E-7 9.102E-7 4 8
24 11279118 Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2. Pubmed 1.294E-10 6.548E-8 6.563E-7 1.637E-6 4 9
25 15866172 Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases. Pubmed 1.294E-10 6.548E-8 6.563E-7 1.637E-6 4 9
26 18551195 Phosphorylation of GSK-3beta by cGMP-dependent protein kinase II promotes hypertrophic differentiation of murine chondrocytes. Pubmed 3.384E-10 1.647E-7 1.650E-6 4.281E-6 4 11
27 17167049 Combinatorial pattern recognition receptor signaling alters the balance of life and death in macrophages. Pubmed 5.073E-10 2.292E-7 2.297E-6 6.417E-6 4 12
28 22617334 Phospho-Bcl-x(L)(Ser62) plays a key role at DNA damage-induced G(2) checkpoint. Pubmed 5.073E-10 2.292E-7 2.297E-6 6.417E-6 4 12
29 9687510 Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB. Pubmed 1.024E-9 2.639E-7 2.645E-6 1.296E-5 4 14
30 25406311 p38α MAPK is required for tooth morphogenesis and enamel secretion. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
31 8626699 Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
32 21610252 p38α Signaling Induces Anoikis and Lumen Formation During Mammary Morphogenesis. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
33 10559227 ErbB2 and ErbB3 receptors mediate inhibition of calcium-dependent chloride secretion in colonic epithelial cells. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
34 7750576 Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
35 17255097 Crystal structure of the p38 alpha-MAPKAP kinase 2 heterodimer. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
36 9218798 Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
37 27012769 p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
38 21336470 Role of p38 mitogen-activated protein kinase isoforms in murine skin inflammation induced by 12-O-tetradecanoylphorbol 13-acetate. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
39 24104471 Gadd45 in modulation of solid tumors and leukemia. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
40 15516490 MKK3 and -6-dependent activation of p38alpha MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
41 20004242 Differential activation of p38MAPK isoforms by MKK6 and MKK3. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
42 21843656 Gadd45a, Gadd45b and Gadd45g expression during mouse embryonic development. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
43 22164285 Balance between MKK6 and MKK3 mediates p38 MAPK associated resistance to cisplatin in NSCLC. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
44 26993769 Genetic variants of GADD45A, GADD45B and MAPK14 predict platinum-based chemotherapy-induced toxicities in Chinese patients with non-small cell lung cancer. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
45 15778394 Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
46 12372778 Three GADD45 isoforms contribute to hypertonic stress phenotype of murine renal inner medullary cells. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
47 15262964 Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
48 20162623 Activin A induction of erythroid differentiation through MKK6-p38alpha/p38beta pathway is inhibited by follistatin. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
49 21715315 Lack of the T cell-specific alternative p38 activation pathway reduces autoimmunity and inflammation. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
50 17588539 A diacylglycerol kinase inhibitor, R59022, stimulates glucose transport through a MKK3/6-p38 signaling pathway in skeletal muscle cells. Pubmed 1.064E-9 2.639E-7 2.645E-6 1.346E-5 3 3
Show 45 more annotations

9: Interaction [Display Chart] 40 input genes in category / 2612 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MAP3K4 MAP3K4 interactions 3.669E-19 9.584E-16 8.094E-15 9.584E-16 11 58
2 int:MAP2K6 MAP2K6 interactions 9.508E-14 1.242E-10 1.049E-9 2.483E-10 8 47
3 int:JUN JUN interactions 1.407E-12 1.225E-9 1.034E-8 3.674E-9 12 296
4 int:MAP2K7 MAP2K7 interactions 2.161E-12 1.411E-9 1.192E-8 5.644E-9 8 68
5 int:MAPK14 MAPK14 interactions 3.511E-10 1.834E-7 1.549E-6 9.171E-7 10 272
6 int:RBPJ RBPJ interactions 6.927E-10 3.015E-7 2.547E-6 1.809E-6 8 138
7 int:MAP2K4 MAP2K4 interactions 1.696E-9 6.328E-7 5.344E-6 4.429E-6 6 52
8 int:DUSP2 DUSP2 interactions 2.336E-9 7.626E-7 6.441E-6 6.101E-6 5 25
9 int:MAPKAPK2 MAPKAPK2 interactions 5.558E-9 1.613E-6 1.362E-5 1.452E-5 6 63
10 int:MAPKAPK5 MAPKAPK5 interactions 8.752E-9 2.286E-6 1.931E-5 2.286E-5 5 32
11 int:MAP3K2 MAP3K2 interactions 3.209E-8 7.620E-6 6.435E-5 8.381E-5 5 41
12 int:MAPK8IP3 MAPK8IP3 interactions 4.108E-8 8.942E-6 7.552E-5 1.073E-4 5 43
13 int:GADD45A GADD45A interactions 4.554E-8 9.150E-6 7.727E-5 1.189E-4 6 89
14 int:ELK1 ELK1 interactions 5.821E-8 1.086E-5 9.172E-5 1.521E-4 5 46
15 int:EEF2K EEF2K interactions 7.248E-8 1.262E-5 1.066E-4 1.893E-4 5 48
16 int:ARRB1 ARRB1 interactions 1.087E-7 1.775E-5 1.499E-4 2.840E-4 8 263
17 int:EGR1 EGR1 interactions 1.596E-7 2.452E-5 2.070E-4 4.168E-4 5 56
18 int:AKT1 AKT1 interactions 1.778E-7 2.580E-5 2.179E-4 4.643E-4 9 393
19 int:EGF EGF interactions 1.918E-7 2.637E-5 2.227E-4 5.010E-4 4 23
20 int:DUSP10 DUSP10 interactions 2.731E-7 3.567E-5 3.012E-4 7.133E-4 4 25
21 int:MAPK9 MAPK9 interactions 3.985E-7 4.957E-5 4.186E-4 1.041E-3 6 128
22 int:NOTCH3 NOTCH3 interactions 5.306E-7 6.299E-5 5.320E-4 1.386E-3 5 71
23 int:JUNB JUNB interactions 6.101E-7 6.790E-5 5.735E-4 1.594E-3 5 73
24 int:GADD45B GADD45B interactions 6.727E-7 6.790E-5 5.735E-4 1.757E-3 4 31
25 int:GCH1 GCH1 interactions 6.727E-7 6.790E-5 5.735E-4 1.757E-3 4 31
26 int:ATF2 ATF2 interactions 6.759E-7 6.790E-5 5.735E-4 1.766E-3 7 227
27 int:MAPK1 MAPK1 interactions 7.844E-7 7.589E-5 6.409E-4 2.049E-3 8 341
28 int:MAML2 MAML2 interactions 1.741E-6 1.624E-4 1.372E-3 4.548E-3 3 11
29 int:MAPK8IP1 MAPK8IP1 interactions 1.925E-6 1.676E-4 1.416E-3 5.029E-3 4 40
30 int:MAPK12 MAPK12 interactions 1.925E-6 1.676E-4 1.416E-3 5.029E-3 4 40
31 int:ATF7 ATF7 interactions 2.130E-6 1.795E-4 1.516E-3 5.564E-3 4 41
32 int:MAPK8IP2 MAPK8IP2 interactions 2.270E-6 1.842E-4 1.555E-3 5.928E-3 5 95
33 int:CREB1 CREB1 interactions 2.327E-6 1.842E-4 1.555E-3 6.078E-3 6 173
34 int:FOS FOS interactions 2.571E-6 1.975E-4 1.668E-3 6.715E-3 6 176
35 int:PLCB2 PLCB2 interactions 3.823E-6 2.774E-4 2.343E-3 9.987E-3 3 14
36 int:MAML3 MAML3 interactions 3.823E-6 2.774E-4 2.343E-3 9.987E-3 3 14
37 int:MAP3K5 MAP3K5 interactions 4.082E-6 2.882E-4 2.434E-3 1.066E-2 5 107
38 int:DUSP16 DUSP16 interactions 4.399E-6 3.024E-4 2.554E-3 1.149E-2 4 49
39 int:NBR1 NBR1 interactions 4.774E-6 3.197E-4 2.700E-3 1.247E-2 4 50
40 int:MAPK10 MAPK10 interactions 6.513E-6 4.253E-4 3.592E-3 1.701E-2 4 54
41 int:CPNE6 CPNE6 interactions 7.109E-6 4.529E-4 3.825E-3 1.857E-2 3 17
42 int:HLTF HLTF interactions 7.539E-6 4.686E-4 3.957E-3 1.969E-2 4 56
43 int:MAPK8 MAPK8 interactions 7.714E-6 4.686E-4 3.957E-3 2.015E-2 6 213
44 int:JUND JUND interactions 8.095E-6 4.805E-4 4.058E-3 2.114E-2 4 57
45 int:MAP2K3 MAP2K3 interactions 8.407E-6 4.880E-4 4.121E-3 2.196E-2 5 124
46 int:MAP3K3 MAP3K3 interactions 9.297E-6 5.279E-4 4.458E-3 2.428E-2 4 59
47 int:NPHS1 NPHS1 interactions 1.010E-5 5.596E-4 4.726E-3 2.638E-2 3 19
48 int:CDKN2A CDKN2A interactions 1.028E-5 5.596E-4 4.726E-3 2.686E-2 6 224
49 int:ILKAP ILKAP interactions 1.063E-5 5.664E-4 4.783E-3 2.775E-2 4 61
50 int:NFATC4 NFATC4 interactions 1.382E-5 7.218E-4 6.096E-3 3.609E-2 3 21
Show 45 more annotations

10: Cytoband [Display Chart] 39 input genes in category / 38 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 5q35 5q35 3.352E-4 1.274E-2
5.385E-2
 1.274E-2 2 24
2 4q22.1-q23 4q22.1-q23 1.125E-3 2.138E-2
9.039E-2
 4.276E-2 1 1
3 9q22.1-q22.2 9q22.1-q22.2 2.249E-3 2.843E-2
1.202E-1
8.547E-2
 1 2
4 19p13.2-p13.1 19p13.2-p13.1 3.372E-3 2.843E-2
1.202E-1
1.281E-1
 1 3
5 3q13.3 3q13.3 4.493E-3 2.843E-2
1.202E-1
1.707E-1
 1 4
6 6p21.3-p21.2 6p21.3-p21.2 4.493E-3 2.843E-2
1.202E-1
1.707E-1
 1 4
7 1p31.2 1p31.2 5.614E-3 2.843E-2
1.202E-1
2.133E-1
 1 5
8 12q24.3 12q24.3 6.733E-3 2.843E-2
1.202E-1
2.558E-1
 1 6
9 8q11 8q11 6.733E-3 2.843E-2
1.202E-1
2.558E-1
 1 6
Show 4 more annotations

11: Transcription Factor Binding Site [Display Chart] 35 input genes in category / 376 annotations before applied cutoff / 9770 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 V$PAX4 01 V$PAX4 01 1.061E-4 3.989E-2
2.596E-1
 3.989E-2 6 217
2 V$SRF Q4 V$SRF Q4 5.593E-4 4.514E-2
2.938E-1
2.103E-1
 5 192
3 V$SP3 Q3 V$SP3 Q3 5.727E-4 4.514E-2
2.938E-1
2.154E-1
 5 193
4 V$SRF Q5 01 V$SRF Q5 01 5.864E-4 4.514E-2
2.938E-1
2.205E-1
 5 194
5 V$MYOD Q6 01 V$MYOD Q6 01 6.003E-4 4.514E-2
2.938E-1
2.257E-1
 5 195

12: Gene Family [Display Chart] 28 input genes in category / 20 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 653 Mitogen-activated protein kinase kinases genenames.org 1.240E-13 2.481E-12 8.925E-12 2.481E-12 5 7
2 651 Mitogen-activated protein kinases genenames.org 7.554E-12 7.554E-11 2.718E-10 1.511E-10 5 13
3 665 Nuclear factors of activated T-cells genenames.org 2.241E-11 1.494E-10 5.374E-10 4.481E-10 4 5
4 1096 Erb-b2 receptor tyrosine kinases genenames.org 6.142E-3 3.069E-2
1.104E-1
1.228E-1
 1 4
5 1040 Ragulator complex genenames.org 7.672E-3 3.069E-2
1.104E-1
1.534E-1
 1 5

13: Coexpression [Display Chart] 40 input genes in category / 4156 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 12471243-TableS2 Human Manning02 624genes ProteinKinases GeneSigDB 2.757E-14 1.146E-10 1.021E-9 1.146E-10 13 368
2 M1885 Genes down-regulated in vascular smooth muscle cells (VSMC) by MAPK8 (JNK1) [GeneID=5599]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.796E-7 3.732E-4 3.325E-3 7.464E-4 8 366
3 M2085 Top genes up-regulated in liver tissue from mice with knockout of ZMPSTE24 [GeneID=10269]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.690E-7 9.268E-4 8.257E-3 2.780E-3 4 40
4 M5923 Genes up-regulated by activation of the PI3K/AKT/mTOR pathway. MSigDB H: Hallmark Gene Sets (v6.0) 1.014E-6 9.666E-4 8.612E-3 4.214E-3 5 105
5 M3413 Genes up-regulated in comparison of microglia cells 1 h after stimulation with IFNG [GeneID=3458] versus microglia cells 24 h after the stimulation. MSigDB C7: Immunologic Signatures (v6.0) 1.163E-6 9.666E-4 8.612E-3 4.833E-3 6 200
6 16790086-tableW1 Rat Liver Perez-Carreon06 290genes GeneSigDB 2.551E-6 1.402E-3 1.249E-2 1.060E-2 6 229
7 M2207 Genes up-regulated in RAW 264.7 cells (macrophage) upon stimulation with TNFSF11 [GeneID=8600]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.639E-6 1.402E-3 1.249E-2 1.097E-2 3 16
8 17096850-TableS3 Human Lung Balko06 130genes GeneSigDB 2.699E-6 1.402E-3 1.249E-2 1.122E-2 5 128
9 M2055 Cluster G28: genes differentially up-regulated in NHEK (normal keratinocyte) compared to SCC12B2 cells (squamous cell carcinoma) by UV-B radiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.347E-6 2.158E-3 1.923E-2 2.222E-2 3 20
10 M15891 Genes down-regulated in MEF cells (embryonic fibroblasts) with TERT [GeneID=7015] knockout, after expression of the gene off a retroviral vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.230E-6 2.158E-3 1.923E-2 2.589E-2 3 21
11 16501597-Table1b Mouse Viral Geserick06 23genes GeneSigDB 6.230E-6 2.158E-3 1.923E-2 2.589E-2 3 21
12 M1289 Genes up-regulated in fetal liver (days E13.5 and E15.5) samples from embryo-specific Cre-lox knockout of MAPK14 [GeneID=1432]. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.230E-6 2.158E-3 1.923E-2 2.589E-2 3 21
13 15277230-Table4 Human Thyroid Morrison04 24genes GeneSigDB 7.206E-6 2.304E-3 2.052E-2 2.995E-2 3 22
14 M2115 Genes correlated with proneural type of glioblastoma multiforme tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.311E-5 3.710E-3 3.305E-2
5.450E-2
 5 177
15 M1391 Cluster 7 of genes distinguishing among different B lymphocyte neoplasms. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.360E-5 3.710E-3 3.305E-2
5.654E-2
 3 27
16 15452549-Table1 Human Ovarian Clarke04 28genes GeneSigDB 1.522E-5 3.710E-3 3.305E-2
6.325E-2
 3 28
17 16434974-Table2 Human StemCell Enk06 334genes GeneSigDB 1.522E-5 3.710E-3 3.305E-2
6.325E-2
 3 28
18 20418243-SuppTable1a Human Leukemia Chiaretti10 405genes GeneSigDB 1.607E-5 3.710E-3 3.305E-2
6.678E-2
 6 316
19 M7196 Genes down-regulated in transitional CR2 [GeneID=1380] low B lymphocytes versus those from cord blood. MSigDB C7: Immunologic Signatures (v6.0) 2.362E-5 4.260E-3 3.796E-2
9.817E-2
 5 200
20 M4597 Genes down-regulated in comparison of naive T cells at day 0 versus CD25+ regulatory T cell (Treg) treated with IL4 [GeneID=3565] at day 10. MSigDB C7: Immunologic Signatures (v6.0) 2.362E-5 4.260E-3 3.796E-2
9.817E-2
 5 200
21 M5890 Genes regulated by NF-kB in response to TNF [GeneID=7124]. MSigDB H: Hallmark Gene Sets (v6.0) 2.362E-5 4.260E-3 3.796E-2
9.817E-2
 5 200
22 M5997 Genes up-regulated in macrophages treated by IL6 [GeneID=3569]: 100min versus 400min. MSigDB C7: Immunologic Signatures (v6.0) 2.362E-5 4.260E-3 3.796E-2
9.817E-2
 5 200
23 M7208 Genes down-regulated in tumors established by injecting MC38 cells (colon cancer): control versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 2.362E-5 4.260E-3 3.796E-2
9.817E-2
 5 200
24 15705876-TableS6 Human Leukemia Passioura05 105genes GeneSigDB 2.460E-5 4.260E-3 3.796E-2
1.022E-1
 4 98
25 16207250-TableS2 Human Lung Ichikawa05 425genes GeneSigDB 2.984E-5 4.770E-3 4.250E-2
1.240E-1
 5 210
26 17894856-SuppList4 Human Breast Yu07 298genes GeneSigDB 2.984E-5 4.770E-3 4.250E-2
1.240E-1
 5 210
27 M4716 Genes up-regulated in SH-SY5Y cells (neuroblastoma) after treatment with epoxomicin [PubChem=3035402], a protease inhibitor causing apoptosis. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.525E-5 8.358E-3
7.446E-2
2.296E-1
 5 239
28 M2377 Genes up-regulated in hypertrophic hearts (due to expression of constitutively active form of PPP3CA [GeneID=5530]) and predicted to be targets of miR-133 microRNA. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.631E-5 8.358E-3
7.446E-2
2.340E-1
 3 43
29 20460173-ImmPortNaturalKillerCellCytotoxicity Human Immune Kong10 135genes ImmPort NaturalKillerCellCytotoxicity GeneSigDB 6.583E-5 9.435E-3
8.406E-2
2.736E-1
 4 126
30 19336457-Table2 Human Brain Tchoghandjian09 153genes GeneSigDB 6.999E-5 9.696E-3
8.639E-2
2.909E-1
 4 128
31 M1597 Cluster 2: genes maximally expressed at 2 h time point during differentiation of 3T3-L1 fibroblasts into adipocytes (cluster 2) in response to adipogenic hormones. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.411E-5 1.262E-2
1.124E-1
3.911E-1
 3 51
32 15120961-Figure4 Mouse Lymphoma Dickinson04 71genes GeneSigDB 1.056E-4 1.365E-2
1.216E-1
4.389E-1
 3 53
33 M8244 Genes changed in INA-6 cells (multiple myeloma, MM) by re-addition of IL6 [GeneID=3569] after its initial withdrawal for 12h. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.105E-4 1.365E-2
1.216E-1
4.592E-1
 4 144
34 15897243-Table1 Human Lymphoma Zhu05 61genes GeneSigDB 1.117E-4 1.365E-2
1.216E-1
4.642E-1
 3 54
35 16467078-Table2b Human Ovarian Wamunyokoli06 10genes MucinousLMPvsCystadenoma GeneSigDB 1.300E-4 1.544E-2
1.375E-1
5.403E-1
 2 10
36 20548326-Table4 Human Stomach Bonelli10 61genes GeneSigDB 1.530E-4 1.766E-2
1.574E-1
6.358E-1
 3 60
37 12946996-Table2 Human Lymphoma Kaminski03 16genes GeneSigDB 1.587E-4 1.770E-2
1.577E-1
6.596E-1
 2 11
38 18667080-TableS4 Human StemCell Kocer08 185genes GeneSigDB 1.619E-4 1.770E-2
1.577E-1
6.726E-1
 4 159
39 M6855 Genes down-regulated in spleens: LPS versus monophosphoryl lipid A. MSigDB C7: Immunologic Signatures (v6.0) 1.823E-4 1.888E-2
1.682E-1
7.575E-1
 4 164
40 18614019-TableS4b Mouse StemCell Fazzio08 466genes GeneSigDB 1.845E-4 1.888E-2
1.682E-1
7.668E-1
 5 309
41 19946333-Table1 Human StemCell Lambert09 12genes GeneSigDB 1.902E-4 1.888E-2
1.682E-1
7.907E-1
 2 12
42 M6810 Genes down-regulated in B lymphocytes: expressing IgM BCR [GeneID=613] fusion and untreated versus expressing IgMG BCR [GeneID=613] fusion and treated by anti-HEL. MSigDB C7: Immunologic Signatures (v6.0) 1.909E-4 1.888E-2
1.682E-1
7.935E-1
 4 166
43 M8940 Genes up-regulated in T reg of aged mice: visceral adipose tissue versus lymph node. MSigDB C7: Immunologic Signatures (v6.0) 1.954E-4 1.888E-2
1.682E-1
8.120E-1
 4 167
44 17533364-TableS2 Human Brain Lastowska07 256genes GeneSigDB 2.187E-4 1.991E-2
1.774E-1
9.090E-1
 4 172
45 M1207 Genes within amplicon 1q32 identified in a copy number alterations study of 191 breast tumor samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.246E-4 1.991E-2
1.774E-1
9.334E-1
 2 13
46 M11585 Genes up-regulated in MCF7 cells (breast cancer) after stimulation with NRG1 [GeneID=3084]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.336E-4 1.991E-2
1.774E-1
9.710E-1
 4 175
47 M6897 Genes up-regulated in T98 cells (glioma) 48 h after treatment with interferon beta. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.522E-4 1.991E-2
1.774E-1
1.000E0
 3 71
48 M4203 Genes with copy number gains in primary neuroblastoma tumors. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.602E-4 1.991E-2
1.774E-1
1.000E0
 4 180
49 15958547-SuppTable2 Human Pancreas Qian05 100genes GeneSigDB 2.628E-4 1.991E-2
1.774E-1
1.000E0
 3 72
50 M377 Genes up-regulated in dendritic cells: wildtype versus NFKB2 [GeneID=4791]. MSigDB C7: Immunologic Signatures (v6.0) 2.829E-4 1.991E-2
1.774E-1
1.000E0
 4 184
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 40 input genes in category / 2921 annotations before applied cutoff / 21829 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal Wilms U U/Kidney Normal Wilms U21 Adult, Development, and Cancer types 1.282E-6 1.988E-3 1.701E-2 3.743E-3 6 192
2 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex post-natal kidney Endothelium/Kidney Normal-Cortex post-natal kidney T11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Cortex post-natal kidney Endothelium/Kidney Normal-Cortex post-natal kidney T11 Adult, Development, and Cancer types 1.361E-6 1.988E-3 1.701E-2 3.976E-3 6 194
3 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal VHL RCC NK cell/Kidney Normal VHL RCC NK14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal VHL RCC NK cell/Kidney Normal VHL RCC NK14 Adult, Development, and Cancer types 1.828E-5 9.350E-3
8.001E-2
5.340E-2
 5 179
4 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Medulla post-natal kidney Endothelium/Kidney Normal-Medulla post-natal kidney T11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Endothelium/Kidney Normal-Medulla post-natal kidney Endothelium/Kidney Normal-Medulla post-natal kidney T11 Adult, Development, and Cancer types 1.878E-5 9.350E-3
8.001E-2
5.485E-2
 5 180
5 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney N11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney Nephron epithelium/Kidney Normal-Medulla post-natal kidney N11 Adult, Development, and Cancer types 2.142E-5 9.350E-3
8.001E-2
6.258E-2
 5 185
6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney R U/Kidney Normal VHL RCC R U/Kidney Normal VHL RCC R18 Adult, Development, and Cancer types 2.256E-5 9.350E-3
8.001E-2
6.590E-2
 5 187
7 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Neutrophil/Kidney Normal-Cortex post-natal kidney Neutrophil Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Neutrophil/Kidney Normal-Cortex post-natal kidney Neutrophil Adult, Development, and Cancer types 2.497E-5 9.350E-3
8.001E-2
7.295E-2
 5 191
8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal Wilms NK cell/Kidney Normal Wilms NK21 Adult, Development, and Cancer types 2.625E-5 9.350E-3
8.001E-2
7.668E-2
 5 193
9 Facebase RNAseq e10.5 Olfactory Pit 500 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 FaceBase_RNAseq 2.881E-5 9.350E-3
8.001E-2
8.415E-2
 7 495
10 Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Fos Top 200 Genes Adult Brain Overview (690k cells, 9 regions, 565 cell clusters) BrainAtlas - Mouse McCarroll Mural Subtype Acta2,Rgs5.Fos Top 200 Genes 1.244E-4 3.553E-2
3.040E-1
3.634E-1
 5 268
11 Facebase RNAseq e10.5 Olfactory Pit 500 K3 FacebaseRNAseq e10.5 Olfactory Pit top-relative-expression-ranked 500 k-means-cluster#3 FaceBase_RNAseq 1.380E-4 3.553E-2
3.040E-1
4.031E-1
 4 144
12 BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup5/Syt6/Syt6,Fos BrainMap/BrainAtlas - Mouse McCarroll/Lineage to Cells - regions (clevel sub)/Neuron/Neuron/excitatory/subGroup5/Syt6/Syt6,Fos BrainMap 1.460E-4 3.553E-2
3.040E-1
4.264E-1
 2 10
13 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK8 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter NK cell/Ureter Normal RCC NK cell/Ureter Normal RCC NK8 Adult, Development, and Cancer types 1.699E-4 3.669E-2
3.140E-1
4.963E-1
 4 152
14 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma/Kidney Normal fetal kidney T6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Renal cell carcinoma/Kidney Normal fetal kidney Renal cell carcinoma/Kidney Normal fetal kidney T6 Adult, Development, and Cancer types 1.971E-4 3.669E-2
3.140E-1
5.758E-1
 4 158
15 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U/Ureter Normal Wilms IF-U/Ureter Normal Wilms IF21 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter IF-U/Ureter Normal Wilms IF-U/Ureter Normal Wilms IF21 Adult, Development, and Cancer types 2.000E-4 3.669E-2
3.140E-1
5.842E-1
 3 62
16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U-U/Kidney Normal fetal kidney U-U/Kidney Normal fetal kidney U6 Adult, Development, and Cancer types 2.169E-4 3.669E-2
3.140E-1
6.336E-1
 4 162
17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Tumour Wilms EN-G/Kidney Tumour Wilms EN12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-G/Kidney Tumour Wilms EN-G/Kidney Tumour Wilms EN12 Adult, Development, and Cancer types 2.787E-4 3.669E-2
3.140E-1
8.141E-1
 4 173
18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney NephrogenicRest Wilms EN-U/Kidney NephrogenicRest Wilms EN17 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-U/Kidney NephrogenicRest Wilms EN-U/Kidney NephrogenicRest Wilms EN17 Adult, Development, and Cancer types 2.988E-4 3.669E-2
3.140E-1
8.729E-1
 3 71
19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney PT-U/Kidney Normal fetal kidney PT-U/Kidney Normal fetal kidney PT6 Adult, Development, and Cancer types 3.379E-4 3.669E-2
3.140E-1
9.871E-1
 4 182
20 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK6 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal fetal kidney NK cell/Kidney Normal fetal kidney NK6 Adult, Development, and Cancer types 3.379E-4 3.669E-2
3.140E-1
9.871E-1
 4 182
21 Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype macrophage-A PND01-03 Top 200 Genes Mouse Lung Development Lungmap Mouse Fluidigm Myeloid Subtype macrophage-A PND01-03 Top 200 Genes 3.450E-4 3.669E-2
3.140E-1
1.000E0
 5 334
22 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney Nephrogenesis/Kidney Normal-Medulla post-natal kidney F11 Adult, Development, and Cancer types 3.450E-4 3.669E-2
3.140E-1
1.000E0
 4 183
23 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex post-natal kidney IF-U/Kidney Normal-Cortex post-natal kidney IF12 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney IF-U/Kidney Normal-Cortex post-natal kidney IF-U/Kidney Normal-Cortex post-natal kidney IF12 Adult, Development, and Cancer types 3.596E-4 3.669E-2
3.140E-1
1.000E0
 4 185
24 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter CD8 T cell/Ureter Normal RCC CD8 T cell/Ureter Normal RCC IT18 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Ureter CD8 T cell/Ureter Normal RCC CD8 T cell/Ureter Normal RCC IT18 Adult, Development, and Cancer types 3.652E-4 3.669E-2
3.140E-1
1.000E0
 3 76
25 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour Wilms Nephron epithelium/Kidney Tumour Wilms N16 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Nephron epithelium/Kidney Tumour Wilms Nephron epithelium/Kidney Tumour Wilms N16 Adult, Development, and Cancer types 3.670E-4 3.669E-2
3.140E-1
1.000E0
 4 186
26 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal fetal kidney MNP1 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney MNP1/Kidney Normal fetal kidney MNP1 Adult, Development, and Cancer types 3.899E-4 3.669E-2
3.140E-1
1.000E0
 4 189
27 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Megakaryocytes/Kidney Normal fetal kidney Megakaryocytes Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Megakaryocytes/Kidney Normal fetal kidney Megakaryocytes Adult, Development, and Cancer types 3.899E-4 3.669E-2
3.140E-1
1.000E0
 4 189
28 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T regulatory/Kidney Normal fetal kidney T regulatory Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney T regulatory/Kidney Normal fetal kidney T regulatory Adult, Development, and Cancer types 3.978E-4 3.669E-2
3.140E-1
1.000E0
 4 190
29 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Medulla post-natal kidney NK cell/Kidney Normal-Medulla post-natal kidney NK11 Adult, Development, and Cancer types 4.057E-4 3.669E-2
3.140E-1
1.000E0
 4 191
30 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex post-natal kidney NK cell/Kidney Normal-Cortex post-natal kidney NK11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney NK cell/Kidney Normal-Cortex post-natal kidney NK cell/Kidney Normal-Cortex post-natal kidney NK11 Adult, Development, and Cancer types 4.138E-4 3.669E-2
3.140E-1
1.000E0
 4 192
31 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Cortex post-natal kidney U U/Kidney Normal-Cortex post-natal kidney U11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney U U/Kidney Normal-Cortex post-natal kidney U U/Kidney Normal-Cortex post-natal kidney U11 Adult, Development, and Cancer types 4.220E-4 3.669E-2
3.140E-1
1.000E0
 4 193
32 DevelopingKidney e15.5 Endothelial cells emap-29977 k5 500 DevelopingKidney e15.5 Endothelial cells emap-29977 k-means-cluster#5 top-relative-expression-ranked 500 Gudmap Mouse MOE430.2 4.220E-4 3.669E-2
3.140E-1
1.000E0
 4 193
33 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal-Medulla post-natal kidney EN-B/Kidney Normal-Medulla post-natal kidney EN11 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney EN-B/Kidney Normal-Medulla post-natal kidney EN-B/Kidney Normal-Medulla post-natal kidney EN11 Adult, Development, and Cancer types 4.303E-4 3.669E-2
3.140E-1
1.000E0
 4 194
34 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium/Kidney Normal-Cortex Wilms N19 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter epithelium/Kidney Normal-Cortex Wilms Ureter epithelium/Kidney Normal-Cortex Wilms N19 Adult, Development, and Cancer types 4.388E-4 3.669E-2
3.140E-1
1.000E0
 4 195
35 Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter others/Kidney Normal-Medulla Wilms Ureter others Human Kidney Cell Atlas/Human/Adult, Development, and Cancer types/Cell Type of Cell Class of Tissue/Kidney Ureter others/Kidney Normal-Medulla Wilms Ureter others Adult, Development, and Cancer types 4.560E-4 3.669E-2
3.140E-1
1.000E0
 4 197
36 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 Human Cell Atlas Human Cell Atlas Stromal Stromal Top 200 4.648E-4 3.669E-2
3.140E-1
1.000E0
 4 198
37 Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes Human Cell Atlas Human Cell Atlas Stromal Stromal Overall Top 200 Genes 4.648E-4 3.669E-2
3.140E-1
1.000E0
 4 198
Show 32 more annotations

15: Computational [Display Chart] 35 input genes in category / 204 annotations before applied cutoff / 10037 genes in category

No results to display

16: MicroRNA [Display Chart] 40 input genes in category / 1649 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1208:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.663E-8 3.005E-5 2.399E-4 9.338E-5 4 66
2 hsa-miR-221-3p:TargetScan hsa-miR-221-3p TargetScan 6.315E-8 3.005E-5 2.399E-4 1.041E-4 6 376
3 hsa-miR-222-3p:TargetScan hsa-miR-222-3p TargetScan 6.315E-8 3.005E-5 2.399E-4 1.041E-4 6 376
4 hsa-miR-552:PITA hsa-miR-552:PITA TOP PITA 7.289E-8 3.005E-5 2.399E-4 1.202E-4 5 190
5 hsa-miR-214-3p:Functional MTI Functional MTI miRTarbase 1.089E-7 3.228E-5 2.578E-4 1.797E-4 5 206
6 hsa-miR-6760-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.236E-7 3.228E-5 2.578E-4 2.038E-4 4 80
7 hsa-miR-3941:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.370E-7 3.228E-5 2.578E-4 2.260E-4 6 429
8 hsa-miR-125a-5p:Functional MTI Functional MTI miRTarbase 4.155E-7 8.564E-5 6.839E-4 6.851E-4 5 270
9 hsa-miR-1182:PITA hsa-miR-1182:PITA TOP PITA 6.317E-7 1.157E-4 9.243E-4 1.042E-3 4 120
10 hsa-miR-6731-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.614E-6 2.419E-4 1.932E-3 2.661E-3 5 356
11 hsa-miR-8085:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.614E-6 2.419E-4 1.932E-3 2.661E-3 5 356
12 hsa-miR-205-5p:Functional MTI Functional MTI miRTarbase 3.318E-6 4.559E-4 3.641E-3 5.471E-3 4 182
13 ACTGTGA,MIR-27B:MSigDB ACTGTGA,MIR-27B:MSigDB MSigDB 4.882E-6 5.413E-4 4.322E-3 8.051E-3 5 447
14 ACTGTGA,MIR-27A:MSigDB ACTGTGA,MIR-27A:MSigDB MSigDB 4.882E-6 5.413E-4 4.322E-3 8.051E-3 5 447
15 hsa-miR-548m:PITA hsa-miR-548m:PITA TOP PITA 5.434E-6 5.413E-4 4.322E-3 8.961E-3 5 457
16 hsa-miR-4270:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.648E-6 5.413E-4 4.322E-3 1.096E-2 4 217
17 hsa-miR-6754-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.770E-6 5.413E-4 4.322E-3 1.116E-2 4 218
18 TGGTGCT,MIR-29A:MSigDB TGGTGCT,MIR-29A:MSigDB MSigDB 6.890E-6 5.413E-4 4.322E-3 1.136E-2 5 480
19 TGGTGCT,MIR-29C:MSigDB TGGTGCT,MIR-29C:MSigDB MSigDB 6.890E-6 5.413E-4 4.322E-3 1.136E-2 5 480
20 TGGTGCT,MIR-29B:MSigDB TGGTGCT,MIR-29B:MSigDB MSigDB 6.890E-6 5.413E-4 4.322E-3 1.136E-2 5 480
21 hsa-miR-4441:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.893E-6 5.413E-4 4.322E-3 1.137E-2 4 219
22 hsa-miR-138-5p:TargetScan hsa-miR-138-5p TargetScan 7.315E-6 5.483E-4 4.378E-3 1.206E-2 5 486
23 hsa-miR-5572:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.118E-5 7.847E-4 6.266E-3 1.844E-2 3 77
24 hsa-miR-659:PITA hsa-miR-659:PITA TOP PITA 1.142E-5 7.847E-4 6.266E-3 1.883E-2 4 249
25 hsa-miR-590-5p:PITA hsa-miR-590-5p:PITA TOP PITA 1.374E-5 8.644E-4 6.902E-3 2.265E-2 4 261
26 hsa-miR-892a:PITA hsa-miR-892a:PITA TOP PITA 1.394E-5 8.644E-4 6.902E-3 2.299E-2 4 262
27 hsa-miR-21:PITA hsa-miR-21:PITA TOP PITA 1.415E-5 8.644E-4 6.902E-3 2.334E-2 4 263
28 ACTTTAT,MIR-142-5P:MSigDB ACTTTAT,MIR-142-5P:MSigDB MSigDB 1.662E-5 9.786E-4 7.814E-3 2.740E-2 4 274
29 hsa-miR-374a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.860E-5 9.851E-4 7.866E-3 3.066E-2 4 282
30 hsa-miR-21-5p:TargetScan hsa-miR-21-5p TargetScan 1.885E-5 9.851E-4 7.866E-3 3.109E-2 4 283
31 hsa-miR-346:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.908E-5 9.851E-4 7.866E-3 3.147E-2 3 92
32 hsa-miR-590-5p:TargetScan hsa-miR-590-5p TargetScan 1.912E-5 9.851E-4 7.866E-3 3.152E-2 4 284
33 GAGCCTG,MIR-484:MSigDB GAGCCTG,MIR-484:MSigDB MSigDB 2.599E-5 1.046E-3 8.353E-3 4.286E-2 3 102
34 AGCACTT,MIR-520C:MSigDB AGCACTT,MIR-520C:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
35 AGCACTT,MIR-520B:MSigDB AGCACTT,MIR-520B:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
36 AGCACTT,MIR-93:MSigDB AGCACTT,MIR-93:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
37 AGCACTT,MIR-372:MSigDB AGCACTT,MIR-372:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
38 AGCACTT,MIR-302A:MSigDB AGCACTT,MIR-302A:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
39 AGCACTT,MIR-520A:MSigDB AGCACTT,MIR-520A:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
40 AGCACTT,MIR-520E:MSigDB AGCACTT,MIR-520E:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
41 AGCACTT,MIR-373:MSigDB AGCACTT,MIR-373:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
42 AGCACTT,MIR-520D:MSigDB AGCACTT,MIR-520D:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
43 AGCACTT,MIR-302B:MSigDB AGCACTT,MIR-302B:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
44 AGCACTT,MIR-526B:MSigDB AGCACTT,MIR-526B:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
45 AGCACTT,MIR-302D:MSigDB AGCACTT,MIR-302D:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
46 AGCACTT,MIR-302C:MSigDB AGCACTT,MIR-302C:MSigDB MSigDB 2.935E-5 1.046E-3 8.353E-3 4.840E-2 4 317
47 hsa-miR-548ah-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.008E-5 1.046E-3 8.353E-3 4.960E-2 4 319
48 hsa-miR-3609:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.045E-5 1.046E-3 8.353E-3
5.021E-2
 4 320
49 hsa-miR-580:PITA hsa-miR-580:PITA TOP PITA 3.195E-5 1.075E-3 8.587E-3
5.269E-2
 4 324
50 hsa-miR-143-3p:TargetScan hsa-miR-143-3p TargetScan 4.078E-5 1.345E-3 1.074E-2
6.725E-2
 4 345
Show 45 more annotations

17: Drug [Display Chart] 40 input genes in category / 12107 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID009549277 K00039 Stitch 5.011E-21 6.067E-17 6.054E-16 6.067E-17 10 32
2 CID000002199 AC1L1D59 Stitch 2.050E-19 1.241E-15 1.239E-14 2.482E-15 15 266
3 CID000005171 pyridinyl imidazole Stitch 5.350E-18 2.159E-14 2.154E-13 6.477E-14 9 36
4 CID000025500 nickel hydroxide Stitch 7.287E-18 2.206E-14 2.201E-13 8.822E-14 14 259
5 CID000005034 AC1L1JGQ Stitch 4.595E-17 1.113E-13 1.110E-12 5.563E-13 10 73
6 CID001249835 ERK inhibitor Stitch 6.798E-17 1.250E-13 1.247E-12 8.230E-13 12 166
7 CID000005103 AC1L1JM9 Stitch 7.226E-17 1.250E-13 1.247E-12 8.748E-13 14 305
8 CID000005637 U0126 Stitch 2.811E-16 4.254E-13 4.245E-12 3.403E-12 15 431
9 CID005353940 SB202190 Stitch 3.731E-16 5.019E-13 5.008E-12 4.517E-12 11 134
10 CID000214797 Ro 31 Stitch 6.620E-16 8.015E-13 7.998E-12 8.015E-12 11 141
11 CID006427013 Thr-Gly Stitch 1.439E-15 1.584E-12 1.581E-11 1.742E-11 7 19
12 CID000005228 SKF86002 Stitch 9.822E-15 9.910E-12 9.889E-11 1.189E-10 7 24
13 CID000002396 GF109203X Stitch 1.267E-14 1.180E-11 1.177E-10 1.534E-10 13 342
14 CID000443069 C11102 Stitch 2.458E-14 2.046E-11 2.042E-10 2.976E-10 9 86
15 CID000008515 SP600125 Stitch 2.627E-14 2.046E-11 2.042E-10 3.181E-10 13 362
16 CID000004701 AC1Q5V5T Stitch 2.704E-14 2.046E-11 2.042E-10 3.273E-10 10 135
17 CID000002399 BiM4 Stitch 4.253E-14 3.029E-11 3.022E-10 5.149E-10 12 283
18 CID009863367 SB-242235 Stitch 5.789E-14 3.749E-11 3.741E-10 7.009E-10 6 14
19 CID000164073 Pkcs Stitch 5.883E-14 3.749E-11 3.741E-10 7.122E-10 11 211
20 CID000003987 oleoyl-lysophosphatidic acid Stitch 7.275E-14 4.404E-11 4.395E-10 8.808E-10 13 392
21 CID006419759 K00077 Stitch 9.795E-14 5.647E-11 5.635E-10 1.186E-9 11 221
22 CID000061671 vanadyl Stitch 1.120E-13 6.162E-11 6.149E-10 1.356E-9 12 307
23 CID000004713 PD98059 Stitch 1.751E-13 9.216E-11 9.196E-10 2.120E-9 11 233
24 CID010258704 Ambotz208527-57-5 Stitch 2.377E-13 1.199E-10 1.196E-9 2.877E-9 6 17
25 CID000434380 satratoxin H Stitch 2.662E-13 1.289E-10 1.286E-9 3.222E-9 5 7
26 CID000000453 hexitol Stitch 2.775E-13 1.292E-10 1.289E-9 3.359E-9 11 243
27 CID000000544 arsenite Stitch 4.770E-13 2.139E-10 2.134E-9 5.775E-9 12 347
28 CID000003499 Go6983 Stitch 5.185E-13 2.242E-10 2.237E-9 6.277E-9 7 40
29 CID000002061 tyrphostin 25 Stitch 6.238E-13 2.604E-10 2.599E-9 7.552E-9 9 122
30 CID000003501 Go6976 Stitch 8.534E-13 3.444E-10 3.437E-9 1.033E-8 10 190
31 CID009549284 MEK1/2 inhibitor Stitch 9.983E-13 3.899E-10 3.891E-9 1.209E-8 10 193
32 CID000435143 NSC-364372 Stitch 1.058E-12 4.001E-10 3.993E-9 1.280E-8 13 484
33 CID000004665 p38 MAP kinase inhibitor Stitch 1.196E-12 4.387E-10 4.378E-9 1.448E-8 9 131
34 CID000004707 PD158780 Stitch 1.477E-12 5.260E-10 5.249E-9 1.789E-8 7 46
35 CID000005174 SC68376 Stitch 1.593E-12 5.510E-10 5.498E-9 1.928E-8 5 9
36 CID000208908 lapatinib Stitch 2.017E-12 6.785E-10 6.770E-9 2.442E-8 8 86
37 CID000004169 metolachlor Stitch 2.438E-12 7.977E-10 7.960E-9 2.951E-8 8 88
38 CID005311098 Ns102 Stitch 3.366E-12 1.073E-9 1.070E-8 4.076E-8 6 25
39 CID000443495 sodium arsenite Stitch 4.622E-12 1.435E-9 1.432E-8 5.595E-8 9 152
40 CID000005083 Ro 31-8220 Stitch 5.725E-12 1.733E-9 1.729E-8 6.932E-8 11 321
41 CID000003591 AC1L1G9T Stitch 6.402E-12 1.890E-9 1.886E-8 7.751E-8 12 433
42 CID005289542 UV-C Stitch 8.694E-12 2.506E-9 2.501E-8 1.053E-7 9 163
43 CID000005164 SB220025 Stitch 8.983E-12 2.529E-9 2.524E-8 1.088E-7 6 29
44 CID006419747 Syk inhibitor Stitch 9.262E-12 2.549E-9 2.543E-8 1.121E-7 7 59
45 CID000001287 AC1L1B55 Stitch 1.111E-11 2.989E-9 2.983E-8 1.345E-7 12 454
46 CID000123631 gefitinib Stitch 1.592E-11 4.191E-9 4.182E-8 1.928E-7 10 255
47 ctd:D013431 Sulfates CTD 2.084E-11 5.286E-9 5.275E-8 2.523E-7 6 33
48 CID000156422 BIRB796 Stitch 2.096E-11 5.286E-9 5.275E-8 2.537E-7 7 66
49 CID000005162 SB202474 Stitch 2.515E-11 6.213E-9 6.200E-8 3.045E-7 5 14
50 CID000003844 KT5720 Stitch 3.292E-11 7.971E-9 7.954E-8 3.986E-7 9 189
Show 45 more annotations

18: Disease [Display Chart] 40 input genes in category / 1194 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C1512127 HER2 gene amplification DisGeNET BeFree 1.144E-5 7.842E-3
6.009E-2
 1.366E-2 4 57
2 C0751587 CADASIL Syndrome DisGeNET Curated 1.314E-5 7.842E-3
6.009E-2
 1.568E-2 3 19
3 C0853879 Invasive carcinoma of breast DisGeNET BeFree 3.834E-5 9.690E-3
7.425E-2
 4.578E-2 7 385
4 C0220650 Metastatic malignant neoplasm to brain DisGeNET BeFree 4.131E-5 9.690E-3
7.425E-2
 4.932E-2 5 158
5 C0035412 Rhabdomyosarcoma DisGeNET Curated 4.230E-5 9.690E-3
7.425E-2
5.051E-2
 7 391
6 C0175704 LEOPARD Syndrome DisGeNET Curated 4.869E-5 9.690E-3
7.425E-2
5.814E-2
 3 29
7 C0030297 Pancreatic Neoplasm DisGeNET Curated 8.409E-5 1.322E-2
1.013E-1
1.004E-1
 7 436
8 C0242129 Thrombotic stroke DisGeNET BeFree 8.856E-5 1.322E-2
1.013E-1
1.057E-1
 2 6
9 C3494652 Severe dementia DisGeNET BeFree 2.115E-4 2.775E-2
2.126E-1
2.526E-1
 2 9
10 C0013274 Patent ductus arteriosus DisGeNET Curated 2.324E-4 2.775E-2
2.126E-1
2.775E-1
 5 228
11 C0338831 Manic DisGeNET Curated 3.527E-4 3.541E-2
2.713E-1
4.212E-1
 3 56
12 C0006413 Burkitt Lymphoma DisGeNET Curated 3.590E-4 3.541E-2
2.713E-1
4.287E-1
 6 390
13 C0796126 AICARDI-GOUTIERES SYNDROME 1 DisGeNET Curated 3.913E-4 3.541E-2
2.713E-1
4.672E-1
 3 58
14 C0027626 Neoplasm Invasiveness DisGeNET Curated 4.152E-4 3.541E-2
2.713E-1
4.957E-1
 4 143
15 C0265268 Adams Oliver syndrome DisGeNET Curated 4.555E-4 3.626E-2
2.778E-1
5.439E-1
 2 13
16 C0027830 neurofibroma DisGeNET Curated 5.230E-4 3.903E-2
2.991E-1
6.244E-1
 3 64
17 C0002793 Anaplasia DisGeNET Curated 5.864E-4 4.119E-2
3.156E-1
7.002E-1
 5 279
18 C0162678 Neurofibromatoses DisGeNET Curated 7.089E-4 4.466E-2
3.422E-1
8.464E-1
 3 71
19 C0085280 Alagille Syndrome DisGeNET Curated 7.892E-4 4.466E-2
3.422E-1
9.424E-1
 2 17
20 C1368683 Epithelioma DisGeNET BeFree 7.896E-4 4.466E-2
3.422E-1
9.428E-1
 5 298
21 C0023487 Acute Promyelocytic Leukemia DisGeNET Curated 9.370E-4 4.466E-2
3.422E-1
1.000E0
 6 468
22 C0011644 Scleroderma DisGeNET Curated 9.847E-4 4.466E-2
3.422E-1
1.000E0
 4 180
23 C0026847 Spinal Muscular Atrophy DisGeNET Curated 1.203E-3 4.466E-2
3.422E-1
1.000E0
 4 190
24 C1854310 Hypotrichosis simplex DisGeNET Curated 1.211E-3 4.466E-2
3.422E-1
1.000E0
 2 21
25 C0279702 Conventional (Clear Cell) Renal Cell Carcinoma DisGeNET Curated 1.226E-3 4.466E-2
3.422E-1
1.000E0
 6 493
26 C0035309 Retinal Diseases DisGeNET Curated 1.245E-3 4.466E-2
3.422E-1
1.000E0
 5 330
27 C0152451 Chronic glomerulonephritis DisGeNET BeFree 1.330E-3 4.466E-2
3.422E-1
1.000E0
 2 22
28 C1956089 Osteophyte DisGeNET BeFree 1.330E-3 4.466E-2
3.422E-1
1.000E0
 2 22
29 C0346109 Malignant Mesothelioma of Peritoneum DisGeNET BeFree 1.584E-3 4.466E-2
3.422E-1
1.000E0
 2 24
30 C0019294 Hernia, Inguinal DisGeNET Curated 1.648E-3 4.466E-2
3.422E-1
1.000E0
 3 95
31 C0154409 Recurrent major depressive episodes DisGeNET Curated 1.719E-3 4.466E-2
3.422E-1
1.000E0
 2 25
32 C0278601 Inflammatory Breast Carcinoma DisGeNET Curated 1.749E-3 4.466E-2
3.422E-1
1.000E0
 3 97
33 C0334299 Carcinoid tumor no ICD-O subtype DisGeNET BeFree 2.020E-3 4.466E-2
3.422E-1
1.000E0
 3 102
34 C0023524 Leukoencephalopathy, Progressive Multifocal DisGeNET BeFree 2.077E-3 4.466E-2
3.422E-1
1.000E0
 3 103
35 C0587248 Costello syndrome (disorder) DisGeNET Curated 2.156E-3 4.466E-2
3.422E-1
1.000E0
 2 28
36 C1519689 Tumor Promotion DisGeNET BeFree 2.254E-3 4.466E-2
3.422E-1
1.000E0
 3 106
37 C0042214 Vaccinia DisGeNET BeFree 2.271E-3 4.466E-2
3.422E-1
1.000E0
 4 226
38 C1282496 Metastasis from malignant tumor of prostate DisGeNET BeFree 2.420E-3 4.466E-2
3.422E-1
1.000E0
 4 230
39 OMIN:611718 HYPOMAGNESEMIA 4, RENAL; HOMG4 OMIM 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
40 cv:CN177831 Infantile myofibromatosis 2 Clinical Variations 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
41 C1843478 Lethal Congenital Contracture Syndrome 2 DisGeNET Curated 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
42 OMIN:125310 CEREBRAL ARTERIOPATHY, AUTOSOMAL DOMINANT, WITH SUBCORTICAL INFARCTS AND LEUKOENCEPHALOPATHY; CADASIL OMIM 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
43 C3809084 MYOFIBROMATOSIS, INFANTILE, 2 DisGeNET Curated 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
44 C4024918 Recurrent subcortical infarcts DisGeNET Curated 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
45 C1855645 Keratoconus posticus circumscriptus DisGeNET BeFree 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
46 C3553748 ADAMS-OLIVER SYNDROME 3 DisGeNET Curated 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
47 C3828832 Neural Glioblastoma DisGeNET BeFree 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
48 cv:C1843478 Lethal congenital contracture syndrome 2 Clinical Variations 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
49 C0151772 Manic psychosis DisGeNET BeFree 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
50 C0344487 Lateral meningocele DisGeNET Curated 2.468E-3 4.466E-2
3.422E-1
1.000E0
 1 1
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