|
ID |
Name |
Source |
pValue |
FDR B&H |
FDR B&Y |
Bonferroni |
Genes from Input
|
Genes in Annotation
|
1
|
15960975
|
Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
|
Pubmed
|
4.999E-13
|
9.542E-10
|
7.760E-9
|
9.542E-10
|
5
|
31
|
2
|
15199122
|
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.
|
Pubmed
|
1.421E-12
|
1.357E-9
|
1.103E-8
|
2.713E-9
|
4
|
9
|
3
|
20093773
|
c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis.
|
Pubmed
|
7.836E-10
|
4.986E-7
|
4.055E-6
|
1.496E-6
|
3
|
6
|
4
|
19131338
|
Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.
|
Pubmed
|
1.371E-9
|
6.543E-7
|
5.321E-6
|
2.617E-6
|
3
|
7
|
5
|
20362541
|
An Oct4-centered protein interaction network in embryonic stem cells.
|
Pubmed
|
2.428E-9
|
9.270E-7
|
7.538E-6
|
4.635E-6
|
5
|
161
|
6
|
24930734
|
The SUMO-specific isopeptidase SENP3 regulates MLL1/MLL2 methyltransferase complexes and controls osteogenic differentiation.
|
Pubmed
|
3.289E-9
|
1.046E-6
|
8.509E-6
|
6.279E-6
|
3
|
9
|
7
|
17998332
|
Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.
|
Pubmed
|
4.697E-9
|
1.121E-6
|
9.115E-6
|
8.967E-6
|
3
|
10
|
8
|
18838538
|
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
|
Pubmed
|
4.697E-9
|
1.121E-6
|
9.115E-6
|
8.967E-6
|
3
|
10
|
9
|
17707229
|
Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.
|
Pubmed
|
6.458E-9
|
1.233E-6
|
1.002E-5
|
1.233E-5
|
3
|
11
|
10
|
18082152
|
Human CpG binding protein interacts with MLL1, MLL2 and hSet1 and regulates Hox gene expression.
|
Pubmed
|
6.458E-9
|
1.233E-6
|
1.002E-5
|
1.233E-5
|
3
|
11
|
11
|
27563068
|
Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.
|
Pubmed
|
8.608E-9
|
1.494E-6
|
1.215E-5
|
1.643E-5
|
3
|
12
|
12
|
27705803
|
A High-Density Map for Navigating the Human Polycomb Complexome.
|
Pubmed
|
1.265E-8
|
2.012E-6
|
1.636E-5
|
2.414E-5
|
6
|
495
|
13
|
14992727
|
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus.
|
Pubmed
|
1.424E-8
|
2.091E-6
|
1.700E-5
|
2.718E-5
|
3
|
14
|
14
|
16510875
|
Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.
|
Pubmed
|
1.779E-8
|
2.264E-6
|
1.841E-5
|
3.396E-5
|
3
|
15
|
15
|
17925232
|
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
|
Pubmed
|
1.779E-8
|
2.264E-6
|
1.841E-5
|
3.396E-5
|
3
|
15
|
16
|
23870121
|
SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.
|
Pubmed
|
2.189E-8
|
2.612E-6
|
2.124E-5
|
4.179E-5
|
3
|
16
|
17
|
21653943
|
Chromatin boundaries require functional collaboration between the hSET1 and NURF complexes.
|
Pubmed
|
2.658E-8
|
2.985E-6
|
2.427E-5
|
5.074E-5
|
3
|
17
|
18
|
17846119
|
USF1 recruits histone modification complexes and is critical for maintenance of a chromatin barrier.
|
Pubmed
|
3.189E-8
|
3.204E-6
|
2.605E-5
|
6.087E-5
|
3
|
18
|
19
|
17500065
|
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
|
Pubmed
|
3.189E-8
|
3.204E-6
|
2.605E-5
|
6.087E-5
|
3
|
18
|
20
|
24993551
|
Effect of the downregulation of SMYD3 expression by RNAi on RIZ1 expression and proliferation of esophageal squamous cell carcinoma.
|
Pubmed
|
1.248E-7
|
1.134E-5
|
9.223E-5
|
2.382E-4
|
2
|
2
|
21
|
17963297
|
Silencing SMYD3 in hepatoma demethylates RIZI promoter induces apoptosis and inhibits cell proliferation and migration.
|
Pubmed
|
1.248E-7
|
1.134E-5
|
9.223E-5
|
2.382E-4
|
2
|
2
|
22
|
20516061
|
Identification and characterization of a novel human PP1 phosphatase complex.
|
Pubmed
|
1.752E-7
|
1.520E-5
|
1.236E-4
|
3.344E-4
|
3
|
31
|
23
|
23892456
|
A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.
|
Pubmed
|
1.832E-7
|
1.520E-5
|
1.236E-4
|
3.497E-4
|
4
|
143
|
24
|
22325351
|
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors.
|
Pubmed
|
2.330E-7
|
1.854E-5
|
1.507E-4
|
4.449E-4
|
3
|
34
|
25
|
20716525
|
Characterization of a novel WDR5-binding site that recruits RbBP5 through a conserved motif to enhance methylation of histone H3 lysine 4 by mixed lineage leukemia protein-1.
|
Pubmed
|
3.742E-7
|
2.551E-5
|
2.075E-4
|
7.144E-4
|
2
|
3
|
26
|
16604156
|
Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis.
|
Pubmed
|
3.742E-7
|
2.551E-5
|
2.075E-4
|
7.144E-4
|
2
|
3
|
27
|
28270438
|
Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.
|
Pubmed
|
3.742E-7
|
2.551E-5
|
2.075E-4
|
7.144E-4
|
2
|
3
|
28
|
27320920
|
In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer.
|
Pubmed
|
3.742E-7
|
2.551E-5
|
2.075E-4
|
7.144E-4
|
2
|
3
|
29
|
20064463
|
A reconfigured pattern of MLL occupancy within mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit.
|
Pubmed
|
7.483E-7
|
4.202E-5
|
3.417E-4
|
1.429E-3
|
2
|
4
|
30
|
23178126
|
Microcephaly gene links trithorax and REST/NRSF to control neural stem cell proliferation and differentiation.
|
Pubmed
|
7.483E-7
|
4.202E-5
|
3.417E-4
|
1.429E-3
|
2
|
4
|
31
|
26927674
|
MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia.
|
Pubmed
|
7.483E-7
|
4.202E-5
|
3.417E-4
|
1.429E-3
|
2
|
4
|
32
|
21220120
|
Structural and biochemical insights into MLL1 core complex assembly.
|
Pubmed
|
7.483E-7
|
4.202E-5
|
3.417E-4
|
1.429E-3
|
2
|
4
|
33
|
20085832
|
Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8.
|
Pubmed
|
7.483E-7
|
4.202E-5
|
3.417E-4
|
1.429E-3
|
2
|
4
|
34
|
21477851
|
Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network.
|
Pubmed
|
7.483E-7
|
4.202E-5
|
3.417E-4
|
1.429E-3
|
2
|
4
|
35
|
17296600
|
Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.
|
Pubmed
|
9.618E-7
|
5.175E-5
|
4.208E-4
|
1.836E-3
|
3
|
54
|
36
|
21884981
|
Interplay between HDAC3 and WDR5 is essential for hypoxia-induced epithelial-mesenchymal transition.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
37
|
24680668
|
A non-active-site SET domain surface crucial for the interaction of MLL1 and the RbBP5/Ash2L heterodimer within MLL family core complexes.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
38
|
16603732
|
Identification of the MLL2 complex as a coactivator for estrogen receptor alpha.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
39
|
24491801
|
UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
40
|
21124902
|
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
41
|
21285357
|
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
42
|
21670200
|
Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
43
|
18026121
|
p38 MAPK signaling regulates recruitment of Ash2L-containing methyltransferase complexes to specific genes during differentiation.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
44
|
19556245
|
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
45
|
17050672
|
Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
46
|
28182322
|
Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.
|
Pubmed
|
1.247E-6
|
5.175E-5
|
4.208E-4
|
2.380E-3
|
2
|
5
|
47
|
20305087
|
A lentiviral functional proteomics approach identifies chromatin remodeling complexes important for the induction of pluripotency.
|
Pubmed
|
1.393E-6
|
5.660E-5
|
4.602E-4
|
2.660E-3
|
3
|
61
|
48
|
24705355
|
CHARGE and Kabuki syndromes: a phenotypic and molecular link.
|
Pubmed
|
1.870E-6
|
7.285E-5
|
5.924E-4
|
3.570E-3
|
2
|
6
|
49
|
24235145
|
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
|
Pubmed
|
1.870E-6
|
7.285E-5
|
5.924E-4
|
3.570E-3
|
2
|
6
|
50
|
7597030
|
Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation.
|
Pubmed
|
2.617E-6
|
8.766E-5
|
7.128E-4
|
4.997E-3
|
2
|
7
|