Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc18_8, positive side

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1: GO: Molecular Function [Display Chart] 8 input genes in category / 34 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001968 fibronectin binding 8.435E-5 2.868E-3 1.181E-2 2.868E-3 2 33
2 GO:0046904 calcium oxalate binding 4.287E-4 7.288E-3 3.001E-2 1.458E-2 1 1
3 GO:0070053 thrombospondin receptor activity 1.714E-3 1.446E-2
5.954E-2
5.827E-2
 1 4
4 GO:0019862 IgA binding 1.714E-3 1.446E-2
5.954E-2
5.827E-2
 1 4
5 GO:0008083 growth factor activity 2.126E-3 1.446E-2
5.954E-2
7.229E-2
 2 166
6 GO:0043237 laminin-1 binding 2.998E-3 1.551E-2
6.388E-2
1.019E-1
 1 7
7 GO:0004252 serine-type endopeptidase activity 3.534E-3 1.551E-2
6.388E-2
1.202E-1
 2 215
8 GO:0019855 calcium channel inhibitor activity 4.280E-3 1.551E-2
6.388E-2
1.455E-1
 1 10
9 GO:0008236 serine-type peptidase activity 4.454E-3 1.551E-2
6.388E-2
1.514E-1
 2 242
10 GO:0017171 serine hydrolase activity 4.563E-3 1.551E-2
6.388E-2
1.551E-1
 2 245
11 GO:0019865 immunoglobulin binding 1.024E-2 3.166E-2
1.304E-1
3.483E-1
 1 24
12 GO:0042056 chemoattractant activity 1.237E-2 3.489E-2
1.437E-1
4.205E-1
 1 29
13 GO:0043236 laminin binding 1.364E-2 3.489E-2
1.437E-1
4.637E-1
 1 32
14 GO:0004175 endopeptidase activity 1.520E-2 3.489E-2
1.437E-1
5.166E-1
 2 457
15 GO:0005246 calcium channel regulator activity 1.618E-2 3.489E-2
1.437E-1
5.501E-1
 1 38
16 GO:0008200 ion channel inhibitor activity 1.660E-2 3.489E-2
1.437E-1
5.644E-1
 1 39
17 GO:0016248 channel inhibitor activity 1.745E-2 3.489E-2
1.437E-1
5.931E-1
 1 41
18 GO:0050840 extracellular matrix binding 2.376E-2 4.488E-2
1.848E-1
8.079E-1
 1 56
19 GO:0005080 protein kinase C binding 2.628E-2 4.702E-2
1.936E-1
8.934E-1
 1 62
Show 14 more annotations

2: GO: Biological Process [Display Chart] 8 input genes in category / 430 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0030203 glycosaminoglycan metabolic process 2.992E-9 8.381E-7 5.567E-6 1.287E-6 5 167
2 GO:0006022 aminoglycan metabolic process 3.898E-9 8.381E-7 5.567E-6 1.676E-6 5 176
3 GO:0006027 glycosaminoglycan catabolic process 7.220E-9 1.035E-6 6.874E-6 3.105E-6 4 61
4 GO:0006026 aminoglycan catabolic process 1.125E-8 1.210E-6 8.036E-6 4.839E-6 4 68
5 GO:0006024 glycosaminoglycan biosynthetic process 9.476E-8 7.033E-6 4.671E-5 4.075E-5 4 115
6 GO:0006023 aminoglycan biosynthetic process 9.813E-8 7.033E-6 4.671E-5 4.220E-5 4 116
7 GO:1901565 organonitrogen compound catabolic process 1.502E-7 9.224E-6 6.127E-5 6.457E-5 5 365
8 GO:1901136 carbohydrate derivative catabolic process 6.260E-7 3.365E-5 2.235E-4 2.692E-4 4 184
9 GO:1903553 positive regulation of extracellular exosome assembly 9.684E-7 4.627E-5 3.073E-4 4.164E-4 2 4
10 GO:1903551 regulation of extracellular exosome assembly 2.420E-6 1.041E-4 6.912E-4 1.041E-3 2 6
11 GO:0071971 extracellular exosome assembly 3.387E-6 1.324E-4 8.795E-4 1.457E-3 2 7
12 GO:0001523 retinoid metabolic process 6.630E-6 2.376E-4 1.578E-3 2.851E-3 3 93
13 GO:0016101 diterpenoid metabolic process 8.250E-6 2.729E-4 1.813E-3 3.548E-3 3 100
14 GO:0006721 terpenoid metabolic process 1.129E-5 3.468E-4 2.304E-3 4.856E-3 3 111
15 GO:1903543 positive regulation of exosomal secretion 1.691E-5 4.847E-4 3.219E-3 7.270E-3 2 15
16 GO:0006720 isoprenoid metabolic process 1.987E-5 5.340E-4 3.547E-3 8.543E-3 3 134
17 GO:1903541 regulation of exosomal secretion 2.189E-5 5.537E-4 3.678E-3 9.413E-3 2 17
18 GO:1990182 exosomal secretion 3.377E-5 8.068E-4 5.359E-3 1.452E-2 2 21
19 GO:1902117 positive regulation of organelle assembly 2.547E-4 5.764E-3 3.829E-2
1.095E-1
 2 57
20 GO:0006887 exocytosis 6.626E-4 1.387E-2
9.213E-2
2.849E-1
 3 438
21 GO:0045921 positive regulation of exocytosis 6.774E-4 1.387E-2
9.213E-2
2.913E-1
 2 93
22 GO:0051047 positive regulation of secretion 7.169E-4 1.399E-2
9.296E-2
3.083E-1
 3 450
23 GO:0048627 myoblast development 8.590E-4 1.399E-2
9.296E-2
3.694E-1
 1 2
24 GO:0070075 tear secretion 8.590E-4 1.399E-2
9.296E-2
3.694E-1
 1 2
25 GO:0001657 ureteric bud development 8.624E-4 1.399E-2
9.296E-2
3.708E-1
 2 105
26 GO:0072163 mesonephric epithelium development 8.788E-4 1.399E-2
9.296E-2
3.779E-1
 2 106
27 GO:0072164 mesonephric tubule development 8.788E-4 1.399E-2
9.296E-2
3.779E-1
 2 106
28 GO:0001823 mesonephros development 9.458E-4 1.453E-2
9.648E-2
4.067E-1
 2 110
29 GO:1903510 mucopolysaccharide metabolic process 1.087E-3 1.612E-2
1.071E-1
4.675E-1
 2 118
30 GO:0042542 response to hydrogen peroxide 1.657E-3 2.238E-2
1.486E-1
7.126E-1
 2 146
31 GO:0072073 kidney epithelium development 1.702E-3 2.238E-2
1.486E-1
7.320E-1
 2 148
32 GO:1902947 regulation of tau-protein kinase activity 1.717E-3 2.238E-2
1.486E-1
7.385E-1
 1 4
33 GO:0008218 bioluminescence 1.717E-3 2.238E-2
1.486E-1
7.385E-1
 1 4
34 GO:1902115 regulation of organelle assembly 2.110E-3 2.637E-2
1.751E-1
9.071E-1
 2 165
35 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling 2.146E-3 2.637E-2
1.751E-1
9.229E-1
 1 5
36 GO:0014074 response to purine-containing compound 2.263E-3 2.703E-2
1.796E-1
9.732E-1
 2 171
37 GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation 2.422E-3 2.815E-2
1.870E-1
1.000E0
 2 177
38 GO:0042167 heme catabolic process 3.004E-3 3.150E-2
2.092E-1
1.000E0
 1 7
39 GO:0006787 porphyrin-containing compound catabolic process 3.004E-3 3.150E-2
2.092E-1
1.000E0
 1 7
40 GO:0046149 pigment catabolic process 3.004E-3 3.150E-2
2.092E-1
1.000E0
 1 7
41 GO:0033015 tetrapyrrole catabolic process 3.004E-3 3.150E-2
2.092E-1
1.000E0
 1 7
42 GO:0017157 regulation of exocytosis 3.232E-3 3.309E-2
2.198E-1
1.000E0
 2 205
43 GO:1901299 negative regulation of hydrogen peroxide-mediated programmed cell death 3.432E-3 3.432E-2
2.280E-1
1.000E0
 1 8
44 GO:0032872 regulation of stress-activated MAPK cascade 3.778E-3 3.609E-2
2.397E-1
1.000E0
 2 222
45 GO:0070302 regulation of stress-activated protein kinase signaling cascade 3.811E-3 3.609E-2
2.397E-1
1.000E0
 2 223
46 GO:0060638 mesenchymal-epithelial cell signaling 3.860E-3 3.609E-2
2.397E-1
1.000E0
 1 9
47 GO:0070572 positive regulation of neuron projection regeneration 4.289E-3 3.881E-2
2.578E-1
1.000E0
 1 10
48 GO:0050730 regulation of peptidyl-tyrosine phosphorylation 4.400E-3 3.881E-2
2.578E-1
1.000E0
 2 240
49 GO:0010951 negative regulation of endopeptidase activity 4.581E-3 3.881E-2
2.578E-1
1.000E0
 2 245
50 GO:0060693 regulation of branching involved in salivary gland morphogenesis 4.716E-3 3.881E-2
2.578E-1
1.000E0
 1 11
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 8 input genes in category / 22 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0043202 lysosomal lumen 2.927E-8 4.581E-7 1.691E-6 6.440E-7 4 88
2 GO:0005796 Golgi lumen 4.164E-8 4.581E-7 1.691E-6 9.161E-7 4 96
3 GO:0005775 vacuolar lumen 8.946E-8 6.560E-7 2.421E-6 1.968E-6 4 116
4 GO:0043034 costamere 8.782E-3 3.156E-2
1.165E-1
1.932E-1
 1 21
5 GO:0005925 focal adhesion 1.094E-2 3.156E-2
1.165E-1
2.406E-1
 2 393
6 GO:0005924 cell-substrate adherens junction 1.120E-2 3.156E-2
1.165E-1
2.465E-1
 2 398
7 GO:0030141 secretory granule 1.131E-2 3.156E-2
1.165E-1
2.489E-1
 2 400
8 GO:0030055 cell-substrate junction 1.148E-2 3.156E-2
1.165E-1
2.525E-1
 2 403
9 GO:0031012 extracellular matrix 1.381E-2 3.376E-2
1.246E-1
3.039E-1
 2 444
10 GO:0005912 adherens junction 1.628E-2 3.581E-2
1.322E-1
3.581E-1
 2 484
11 GO:0031093 platelet alpha granule lumen 2.286E-2 4.571E-2
1.687E-1
5.028E-1
 1 55
Show 6 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 17 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0007720 Flat cornea 3.821E-3 2.060E-2
7.084E-2
6.495E-2
 1 9
2 HP:0000399 Prelingual sensorineural hearing impairment 3.821E-3 2.060E-2
7.084E-2
6.495E-2
 1 9
3 HP:0011474 Childhood onset sensorineural hearing impairment 4.669E-3 2.060E-2
7.084E-2
7.937E-2
 1 11
4 HP:0008538 Sensorineural deafness 6.364E-3 2.060E-2
7.084E-2
1.082E-1
 1 15
5 HP:0001084 Corneal arcus 7.211E-3 2.060E-2
7.084E-2
1.226E-1
 1 17
6 HP:0008011 Peripheral opacification of the cornea 7.634E-3 2.060E-2
7.084E-2
1.298E-1
 1 18
7 HP:0000404 Deafness 8.481E-3 2.060E-2
7.084E-2
1.442E-1
 1 20
Show 2 more annotations

5: Mouse Phenotype [Display Chart] 7 input genes in category / 159 annotations before applied cutoff / 10355 genes in category

No results to display

6: Domain [Display Chart] 8 input genes in category / 80 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 PS00964 SYNDECAN PROSITE 2.044E-10 5.450E-9 2.706E-8 1.635E-8 3 4
2 IPR001050 Syndecan InterPro 2.044E-10 5.450E-9 2.706E-8 1.635E-8 3 4
3 IPR030479 Syndecan CS InterPro 2.044E-10 5.450E-9 2.706E-8 1.635E-8 3 4
4 PF01034 Syndecan Pfam 1.787E-9 2.859E-8 1.420E-7 1.430E-7 3 7
5 IPR027789 Syndecan/Neurexin dom InterPro 1.787E-9 2.859E-8 1.420E-7 1.430E-7 3 7
6 IPR003585 Neurexin-like InterPro 1.856E-8 2.121E-7 1.053E-6 1.485E-6 3 14
7 SM00294 4.1m SMART 1.856E-8 2.121E-7 1.053E-6 1.485E-6 3 14
8 IPR033530 Lacritin InterPro 4.270E-4 2.847E-3 1.414E-2 3.416E-2 1 1
9 IPR027284 Hepatocyte GF InterPro 4.270E-4 2.847E-3 1.414E-2 3.416E-2 1 1
10 IPR031190 Syndecan-1 InterPro 4.270E-4 2.847E-3 1.414E-2 3.416E-2 1 1
11 IPR031201 Syndecan-2 InterPro 4.270E-4 2.847E-3 1.414E-2 3.416E-2 1 1
12 IPR029856 AMBP InterPro 4.270E-4 2.847E-3 1.414E-2 3.416E-2 1 1
13 IPR002968 A1-microglobln InterPro 8.539E-4 4.879E-3 2.423E-2
6.831E-2
 1 2
14 IPR024174 HGF-like InterPro 8.539E-4 4.879E-3 2.423E-2
6.831E-2
 1 2
15 SM00473 PAN AP SMART 2.133E-3 1.138E-2
5.650E-2
1.707E-1
 1 5
16 IPR003609 Pan app InterPro 2.986E-3 1.327E-2
6.589E-2
2.389E-1
 1 7
17 PF00024 PAN 1 Pfam 2.986E-3 1.327E-2
6.589E-2
2.389E-1
 1 7
18 PS50948 PAN PROSITE 2.986E-3 1.327E-2
6.589E-2
2.389E-1
 1 7
19 IPR022272 Lipocalin CS InterPro 5.114E-3 1.630E-2
8.094E-2
4.091E-1
 1 12
20 IPR021158 Pept M10A Zn BS InterPro 6.388E-3 1.630E-2
8.094E-2
5.111E-1
 1 15
21 PS00213 LIPOCALIN PROSITE 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
22 PS00021 KRINGLE 1 PROSITE 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
23 IPR018486 Hemopexin CS InterPro 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
24 PS50070 KRINGLE 2 PROSITE 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
25 IPR000001 Kringle InterPro 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
26 IPR018056 Kringle CS InterPro 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
27 SM00130 KR SMART 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
28 PF00051 Kringle Pfam 7.237E-3 1.630E-2
8.094E-2
5.790E-1
 1 17
29 IPR020901 Prtase inh Kunz-CS InterPro 7.662E-3 1.630E-2
8.094E-2
6.129E-1
 1 18
30 4.10.410.10 - Gene3D 7.662E-3 1.630E-2
8.094E-2
6.129E-1
 1 18
31 SM00131 KU SMART 7.662E-3 1.630E-2
8.094E-2
6.129E-1
 1 18
32 IPR016293 Pept M10A stromelysin-type InterPro 7.662E-3 1.630E-2
8.094E-2
6.129E-1
 1 18
33 IPR002345 Lipocalin InterPro 7.662E-3 1.630E-2
8.094E-2
6.129E-1
 1 18
34 PF00014 Kunitz BPTI Pfam 8.086E-3 1.630E-2
8.094E-2
6.469E-1
 1 19
35 PS00280 BPTI KUNITZ 1 PROSITE 8.086E-3 1.630E-2
8.094E-2
6.469E-1
 1 19
36 PS50279 BPTI KUNITZ 2 PROSITE 8.086E-3 1.630E-2
8.094E-2
6.469E-1
 1 19
37 IPR002477 Peptidoglycan-bd-like InterPro 8.510E-3 1.630E-2
8.094E-2
6.808E-1
 1 20
38 PF01471 PG binding 1 Pfam 8.510E-3 1.630E-2
8.094E-2
6.808E-1
 1 20
39 IPR033739 M10A MMP InterPro 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
40 PS51642 HEMOPEXIN 2 PROSITE 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
41 SM00120 HX SMART 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
42 2.110.10.10 - Gene3D 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
43 IPR018487 Hemopexin-like repeat InterPro 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
44 IPR002223 Kunitz BPTI InterPro 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
45 PS00024 HEMOPEXIN PROSITE 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
46 IPR000585 Hemopexin-like dom InterPro 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
47 IPR021190 Pept M10A InterPro 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
48 PF00045 Hemopexin Pfam 9.781E-3 1.630E-2
8.094E-2
7.825E-1
 1 23
49 PF00413 Peptidase M10 Pfam 1.020E-2 1.666E-2
8.273E-2
8.163E-1
 1 24
50 SM00235 ZnMc SMART 1.232E-2 1.932E-2
9.595E-2
9.855E-1
 1 29
Show 45 more annotations

7: Pathway [Display Chart] 7 input genes in category / 137 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 137947 Proteogylcan syndecan-mediated signaling events BioSystems: Pathway Interaction Database 4.353E-10 3.567E-8 1.962E-7 5.963E-8 3 4
2 1269011 Diseases associated with glycosaminoglycan metabolism BioSystems: REACTOME 5.207E-10 3.567E-8 1.962E-7 7.134E-8 4 26
3 1269022 Defective EXT2 causes exostoses 2 BioSystems: REACTOME 2.389E-8 8.184E-7 4.502E-6 3.274E-6 3 12
4 1269021 Defective EXT1 causes exostoses 1, TRPS2 and CHDS BioSystems: REACTOME 2.389E-8 8.184E-7 4.502E-6 3.274E-6 3 12
5 1269010 Diseases of glycosylation BioSystems: REACTOME 7.311E-8 1.799E-6 9.897E-6 1.002E-5 4 86
6 1269015 Defective B3GAT3 causes JDSSDHD BioSystems: REACTOME 1.051E-7 1.799E-6 9.897E-6 1.439E-5 3 19
7 1309217 Defective B3GALT6 causes EDSP2 and SEMDJL1 BioSystems: REACTOME 1.051E-7 1.799E-6 9.897E-6 1.439E-5 3 19
8 1269014 Defective B4GALT7 causes EDS, progeroid type BioSystems: REACTOME 1.051E-7 1.799E-6 9.897E-6 1.439E-5 3 19
9 1270255 Syndecan interactions BioSystems: REACTOME 1.441E-7 1.975E-6 1.086E-5 1.975E-5 3 21
10 1269983 HS-GAG degradation BioSystems: REACTOME 1.441E-7 1.975E-6 1.086E-5 1.975E-5 3 21
11 1269981 A tetrasaccharide linker sequence is required for GAG synthesis BioSystems: REACTOME 2.814E-7 3.505E-6 1.928E-5 3.856E-5 3 26
12 1269972 Glycosaminoglycan metabolism BioSystems: REACTOME 3.312E-7 3.781E-6 2.080E-5 4.537E-5 4 125
13 1269982 HS-GAG biosynthesis BioSystems: REACTOME 4.860E-7 5.121E-6 2.817E-5 6.658E-5 3 31
14 1269624 Retinoid metabolism and transport BioSystems: REACTOME 1.427E-6 1.397E-5 7.684E-5 1.956E-4 3 44
15 1270254 Non-integrin membrane-ECM interactions BioSystems: REACTOME 1.635E-6 1.494E-5 8.216E-5 2.240E-4 3 46
16 152665 Malaria BioSystems: KEGG 1.983E-6 1.698E-5 9.341E-5 2.717E-4 3 49
17 782000 Proteoglycans in cancer BioSystems: KEGG 2.312E-6 1.809E-5 9.953E-5 3.167E-4 4 203
18 1269984 Chondroitin sulfate/dermatan sulfate metabolism BioSystems: REACTOME 2.377E-6 1.809E-5 9.953E-5 3.257E-4 3 52
19 1339147 Metabolism of fat-soluble vitamins BioSystems: REACTOME 2.519E-6 1.817E-5 9.992E-5 3.451E-4 3 53
20 1269980 Heparan sulfate/heparin (HS-GAG) metabolism BioSystems: REACTOME 2.667E-6 1.827E-5 1.005E-4 3.654E-4 3 54
21 1269957 Metabolism of carbohydrates BioSystems: REACTOME 1.050E-5 6.624E-5 3.644E-4 1.438E-3 4 297
22 1270244 Extracellular matrix organization BioSystems: REACTOME 1.064E-5 6.624E-5 3.644E-4 1.457E-3 4 298
23 1269623 Visual phototransduction BioSystems: REACTOME 1.771E-5 1.055E-4 5.804E-4 2.427E-3 3 101
24 138046 Syndecan-1-mediated signaling events BioSystems: Pathway Interaction Database 3.671E-5 2.095E-4 1.153E-3 5.029E-3 2 17
25 1474302 Fluid shear stress and atherosclerosis BioSystems: KEGG 4.917E-5 2.646E-4 1.455E-3 6.736E-3 3 142
26 1269373 Cell surface interactions at the vascular wall BioSystems: REACTOME 5.021E-5 2.646E-4 1.455E-3 6.879E-3 3 143
27 83069 Cell adhesion molecules (CAMs) BioSystems: KEGG 5.234E-5 2.656E-4 1.461E-3 7.170E-3 3 145
28 M5880 Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins MSigDB C2 BIOCARTA (v6.0) 8.557E-5 4.187E-4 2.303E-3 1.172E-2 3 171
29 1270144 Metabolism of vitamins and cofactors BioSystems: REACTOME 9.482E-5 4.479E-4 2.464E-3 1.299E-2 3 177
30 137989 FGF signaling pathway BioSystems: Pathway Interaction Database 2.894E-4 1.322E-3 7.270E-3 3.965E-2 2 47
31 83068 ECM-receptor interaction BioSystems: KEGG 8.808E-4 3.893E-3 2.141E-2
1.207E-1
 2 82
32 1457803 MET activates STAT3 BioSystems: REACTOME 1.686E-3 7.218E-3 3.970E-2
2.310E-1
 1 3
33 1457798 MET activates PTPN11 BioSystems: REACTOME 2.809E-3 1.099E-2
6.047E-2
3.848E-1
 1 5
34 PW:0000366 altered melanocortin system Pathway Ontology 2.809E-3 1.099E-2
6.047E-2
3.848E-1
 1 5
35 1457801 MET interacts with TNS proteins BioSystems: REACTOME 2.809E-3 1.099E-2
6.047E-2
3.848E-1
 1 5
36 1457797 MET activates PI3K/AKT signaling BioSystems: REACTOME 3.369E-3 1.248E-2
6.863E-2
4.616E-1
 1 6
37 1457795 MET Receptor Activation BioSystems: REACTOME 3.369E-3 1.248E-2
6.863E-2
4.616E-1
 1 6
38 1269019 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) BioSystems: REACTOME 3.930E-3 1.346E-2
7.404E-2
5.384E-1
 1 7
39 1269020 Defective CHST6 causes MCDC1 BioSystems: REACTOME 3.930E-3 1.346E-2
7.404E-2
5.384E-1
 1 7
40 1309216 Defective ST3GAL3 causes MCT12 and EIEE15 BioSystems: REACTOME 3.930E-3 1.346E-2
7.404E-2
5.384E-1
 1 7
41 PW:0000540 obesity disease Pathway Ontology 4.490E-3 1.500E-2
8.254E-2
6.152E-1
 1 8
42 1457804 MET receptor recycling BioSystems: REACTOME 5.610E-3 1.787E-2
9.833E-2
7.686E-1
 1 10
43 PW:0000365 melanocortin system Pathway Ontology 5.610E-3 1.787E-2
9.833E-2
7.686E-1
 1 10
44 1457802 MET activates RAP1 and RAC1 BioSystems: REACTOME 6.170E-3 1.838E-2
1.011E-1
8.453E-1
 1 11
45 1457796 MET activates RAS signaling BioSystems: REACTOME 6.170E-3 1.838E-2
1.011E-1
8.453E-1
 1 11
46 PW:0000578 scatter factor/hepatocyte growth factor signaling Pathway Ontology 6.170E-3 1.838E-2
1.011E-1
8.453E-1
 1 11
47 1269979 Keratan sulfate degradation BioSystems: REACTOME 6.729E-3 1.961E-2
1.079E-1
9.219E-1
 1 12
48 M3468 Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix MSigDB C2 BIOCARTA (v6.0) 7.173E-3 2.047E-2
1.126E-1
9.827E-1
 2 238
49 1269898 Scavenging of heme from plasma BioSystems: REACTOME 1.064E-2 2.974E-2
1.636E-1
1.000E0
 1 19
50 1457800 MET activates PTK2 signaling BioSystems: REACTOME 1.119E-2 3.067E-2
1.687E-1
1.000E0
 1 20
Show 45 more annotations

8: Pubmed [Display Chart] 8 input genes in category / 2118 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 16982797 Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. Pubmed 2.763E-14 5.852E-11 4.820E-10 5.852E-11 4 7
2 21114861 Current concepts regarding the HTLV-1 receptor complex. Pubmed 6.031E-12 3.930E-9 3.237E-8 1.277E-8 3 3
3 18093920 Transmembrane domains of the syndecan family of growth factor coreceptors display a hierarchy of homotypic and heterotypic interactions. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
4 24956062 Cell communication using intrinsically disordered proteins: what can syndecans say? Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
5 25286301 The NTR domain of procollagen C-proteinase enhancer-1 (PCPE-1) mediates PCPE-1 binding to syndecans-1, -2 and -4 as well as fibronectin. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
6 9111037 Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
7 9276666 Molecular cloning, genomic organization, promoter activity, and tissue-specific expression of the mouse ryudocan gene. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
8 7812048 Members of the syndecan family of heparan sulfate proteoglycans are expressed in distinct cell-, tissue-, and development-specific patterns. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
9 11024024 Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
10 11567105 Heparin binding by the HIV-1 tat protein transduction domain. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
11 10497173 Multiple interactions of HIV-I Tat protein with size-defined heparin oligosaccharides. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
12 8570206 HIV-tat protein is a heparin-binding angiogenic growth factor. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
13 12885232 Structural and dynamic properties of the HIV-1 tat transduction domain in the free and heparin-bound states. Pubmed 2.412E-11 3.930E-9 3.237E-8 5.109E-8 3 4
14 15797855 Heparan sulfate targets the HIV-1 envelope glycoprotein gp120 coreceptor binding site. Pubmed 6.030E-11 6.722E-9 5.536E-8 1.277E-7 3 5
15 21820515 The survival promoting peptide Y-P30 promotes cellular migration. Pubmed 6.030E-11 6.722E-9 5.536E-8 1.277E-7 3 5
16 1765004 Expression of syndecan, a putative low affinity fibroblast growth factor receptor, in the early mouse embryo. Pubmed 6.030E-11 6.722E-9 5.536E-8 1.277E-7 3 5
17 9660868 Human CASK/LIN-2 binds syndecan-2 and protein 4.1 and localizes to the basolateral membrane of epithelial cells. Pubmed 6.030E-11 6.722E-9 5.536E-8 1.277E-7 3 5
18 16157597 A highly conserved arginine in gp120 governs HIV-1 binding to both syndecans and CCR5 via sulfated motifs. Pubmed 6.030E-11 6.722E-9 5.536E-8 1.277E-7 3 5
19 9342064 HIV-1 Tat protein exits from cells via a leaderless secretory pathway and binds to extracellular matrix-associated heparan sulfate proteoglycans through its basic region. Pubmed 6.030E-11 6.722E-9 5.536E-8 1.277E-7 3 5
20 11784020 Syndecan-3 and syndecan-4 specifically mark skeletal muscle satellite cells and are implicated in satellite cell maintenance and muscle regeneration. Pubmed 1.206E-10 1.216E-8 1.002E-7 2.554E-7 3 6
21 12112370 Increased syndecan expression by pleiotrophin and FGF receptor-expressing astrocytes in injured brain tissue. Pubmed 1.206E-10 1.216E-8 1.002E-7 2.554E-7 3 6
22 19822079 Expression of basic fibroblast growth factor, its receptors and syndecans in bladder cancer. Pubmed 2.110E-10 1.943E-8 1.600E-7 4.469E-7 3 7
23 16817962 Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120. Pubmed 2.110E-10 1.943E-8 1.600E-7 4.469E-7 3 7
24 16989989 Syndecan-4 dependent FGF stimulation of mouse vibrissae growth. Pubmed 3.376E-10 2.979E-8 2.454E-7 7.150E-7 3 8
25 15381701 Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. Pubmed 5.063E-10 4.290E-8 3.533E-7 1.072E-6 3 9
26 7690138 The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Pubmed 7.233E-10 5.674E-8 4.673E-7 1.532E-6 3 10
27 16934308 R5- and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: implication for mechanisms of sexual transmission. Pubmed 7.233E-10 5.674E-8 4.673E-7 1.532E-6 3 10
28 12761845 Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Pubmed 1.326E-9 1.003E-7 8.259E-7 2.808E-6 3 12
29 7959737 Mapping of the syndecan genes in the mouse: linkage with members of the myc gene family. Pubmed 1.723E-9 1.259E-7 1.037E-6 3.650E-6 3 13
30 22660413 Syndecan-syntenin-ALIX regulates the biogenesis of exosomes. Pubmed 2.193E-9 1.548E-7 1.275E-6 4.645E-6 3 14
31 12684764 Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. Pubmed 4.096E-9 2.798E-7 2.305E-6 8.675E-6 3 17
32 12571251 Syndecan-1 and -4 synthesized simultaneously by mouse mammary gland epithelial cells bear heparan sulfate chains that are apparently structurally indistinguishable. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
33 16636895 Syndecan-1 and syndecan-4 are overexpressed in an estrogen receptor-negative, highly proliferative breast carcinoma subtype. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
34 22745764 Syndecan-1 enhances proliferation, migration and metastasis of HT-1080 cells in cooperation with syndecan-2. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
35 21414405 Syndecan-1 and -4 differentially regulate oncogenic K-ras dependent cell invasion into collagen through α2β1 integrin and MT1-MMP. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
36 25202019 Cytoplasmic domain interactions of syndecan-1 and syndecan-4 with α6β4 integrin mediate human epidermal growth factor receptor (HER1 and HER2)-dependent motility and survival. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
37 19450993 The expression of syndecan-1 and -2 is associated with Gleason score and epithelial-mesenchymal transition markers, E-cadherin and beta-catenin, in prostate cancer. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
38 1537865 Molecular cloning and expression of two distinct cDNA-encoding heparan sulfate proteoglycan core proteins from a rat endothelial cell line. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
39 16253987 Transmembrane domain-induced oligomerization is crucial for the functions of syndecan-2 and syndecan-4. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
40 14999018 Cooperation of syndecan-2 and syndecan-4 among cell surface heparan sulfate proteoglycans in the actin cytoskeletal organization of Lewis lung carcinoma cells. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
41 22238310 Entry of human T-cell leukemia virus type 1 is augmented by heparin sulfate proteoglycans bearing short heparin-like structures. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
42 12665470 Syndecans in inflammation. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
43 26391658 Transmembrane proteoglycans control stretch-activated channels to set cytosolic calcium levels. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
44 21430259 Syndecan-1 and syndecan-4 are independent indicators in breast carcinoma. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
45 18342939 Syndecan-2 and -4 expressed on activated primary human CD4+ lymphocytes can regulate T cell activation. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
46 8187643 Spatial and temporal changes in the expression of fibroglycan (syndecan-2) during mouse embryonic development. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
47 25361632 Association of heparan sulfate proteoglycans SDC1 and SDC4 polymorphisms with breast cancer in an Australian Caucasian population. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
48 21987406 Expression of heparan sulfate proteoglycans in murine models of experimental colitis. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
49 21317913 Altered expression patterns of syndecan-1 and -2 predict biochemical recurrence in prostate cancer. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
50 21148276 Syndecan-1 and syndecan-2 play key roles in herpes simplex virus type-1 infection. Pubmed 3.839E-8 1.506E-6 1.240E-5 8.131E-5 2 2
Show 45 more annotations

9: Interaction [Display Chart] 8 input genes in category / 256 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:HGF HGF interactions 5.938E-7 9.487E-5 5.810E-4 1.520E-4 3 40
2 int:FGF2 FGF2 interactions 7.412E-7 9.487E-5 5.810E-4 1.897E-4 3 43
3 int:SDC1 SDC1 interactions 1.572E-6 1.341E-4 8.214E-4 4.024E-4 3 55
4 int:CASK CASK interactions 1.538E-5 9.843E-4 6.028E-3 3.937E-3 3 117
5 int:PRDM10 PRDM10 interactions 2.724E-5 1.395E-3 8.542E-3 6.974E-3 2 18
6 int:FARP1 FARP1 interactions 4.109E-5 1.753E-3 1.074E-2 1.052E-2 2 22
7 int:GMEB2 GMEB2 interactions 5.333E-5 1.846E-3 1.131E-2 1.365E-2 2 25
8 int:FGF1 FGF1 interactions 6.715E-5 1.846E-3 1.131E-2 1.719E-2 2 28
9 int:GMEB1 GMEB1 interactions 7.211E-5 1.846E-3 1.131E-2 1.846E-2 2 29
10 int:DHRS2 DHRS2 interactions 7.211E-5 1.846E-3 1.131E-2 1.846E-2 2 29
11 int:AMPD2 AMPD2 interactions 9.369E-5 2.181E-3 1.335E-2 2.399E-2 2 33
12 int:SDCBP SDCBP interactions 1.068E-4 2.200E-3 1.347E-2 2.734E-2 3 224
13 int:GPR183 GPR183 interactions 1.117E-4 2.200E-3 1.347E-2 2.860E-2 2 36
14 int:CCL5 CCL5 interactions 1.525E-4 2.788E-3 1.708E-2 3.903E-2 2 42
15 int:PYHIN1 PYHIN1 interactions 1.796E-4 2.930E-3 1.794E-2 4.598E-2 3 267
16 int:LACRT LACRT interactions 1.831E-4 2.930E-3 1.794E-2 4.688E-2 2 46
17 int:VANGL1 VANGL1 interactions 1.995E-4 3.004E-3 1.840E-2
5.107E-2
 2 48
18 int:MDK MDK interactions 2.817E-4 3.795E-3 2.324E-2
7.211E-2
 2 57
19 int:PARP2 PARP2 interactions 2.817E-4 3.795E-3 2.324E-2
7.211E-2
 2 57
20 int:SDC2 SDC2 interactions 7.489E-4 9.586E-3
5.871E-2
1.917E-1
 2 93
21 int:VTN VTN interactions 1.523E-3 1.856E-2
1.137E-1
3.898E-1
 2 133
22 int:EPHA2 EPHA2 interactions 1.782E-3 2.011E-2
1.231E-1
4.561E-1
 2 144
23 int:SLC2A6 SLC2A6 interactions 1.807E-3 2.011E-2
1.231E-1
4.625E-1
 1 4
24 int:COX8A COX8A interactions 2.258E-3 2.312E-2
1.416E-1
5.780E-1
 1 5
25 int:C22orf31 C22orf31 interactions 2.258E-3 2.312E-2
1.416E-1
5.780E-1
 1 5
26 int:DOP1B DOP1B interactions 2.709E-3 2.391E-2
1.464E-1
6.934E-1
 1 6
27 int:HPN HPN interactions 2.709E-3 2.391E-2
1.464E-1
6.934E-1
 1 6
28 int:TTLL9 TTLL9 interactions 2.709E-3 2.391E-2
1.464E-1
6.934E-1
 1 6
29 int:SEMA3C SEMA3C interactions 2.709E-3 2.391E-2
1.464E-1
6.934E-1
 1 6
30 int:CASP5 CASP5 interactions 3.160E-3 2.451E-2
1.501E-1
8.088E-1
 1 7
31 int:THUMPD2 THUMPD2 interactions 3.160E-3 2.451E-2
1.501E-1
8.088E-1
 1 7
32 int:ANOS1 ANOS1 interactions 3.160E-3 2.451E-2
1.501E-1
8.088E-1
 1 7
33 int:SULF1 SULF1 interactions 3.160E-3 2.451E-2
1.501E-1
8.088E-1
 1 7
34 int:PRAP1 PRAP1 interactions 3.610E-3 2.649E-2
1.623E-1
9.242E-1
 1 8
35 int:CNPY4 CNPY4 interactions 4.061E-3 2.649E-2
1.623E-1
1.000E0
 1 9
36 int:CCDC148 CCDC148 interactions 4.061E-3 2.649E-2
1.623E-1
1.000E0
 1 9
37 int:PCSK1N PCSK1N interactions 4.061E-3 2.649E-2
1.623E-1
1.000E0
 1 9
38 int:HAPLN1 HAPLN1 interactions 4.061E-3 2.649E-2
1.623E-1
1.000E0
 1 9
39 int:NBEAL1 NBEAL1 interactions 4.511E-3 2.649E-2
1.623E-1
1.000E0
 1 10
40 int:REG3A REG3A interactions 4.511E-3 2.649E-2
1.623E-1
1.000E0
 1 10
41 int:CYP2C18 CYP2C18 interactions 4.961E-3 2.649E-2
1.623E-1
1.000E0
 1 11
42 int:F11 F11 interactions 4.961E-3 2.649E-2
1.623E-1
1.000E0
 1 11
43 int:CSF2RA CSF2RA interactions 4.961E-3 2.649E-2
1.623E-1
1.000E0
 1 11
44 int:HGFAC HGFAC interactions 4.961E-3 2.649E-2
1.623E-1
1.000E0
 1 11
45 int:GAL GAL interactions 4.961E-3 2.649E-2
1.623E-1
1.000E0
 1 11
46 int:MAN1A1 MAN1A1 interactions 5.411E-3 2.649E-2
1.623E-1
1.000E0
 1 12
47 int:PF4 PF4 interactions 5.411E-3 2.649E-2
1.623E-1
1.000E0
 1 12
48 int:RFTN1 RFTN1 interactions 5.411E-3 2.649E-2
1.623E-1
1.000E0
 1 12
49 int:PCYOX1L PCYOX1L interactions 5.861E-3 2.649E-2
1.623E-1
1.000E0
 1 13
50 int:RSPO1 RSPO1 interactions 5.861E-3 2.649E-2
1.623E-1
1.000E0
 1 13
Show 45 more annotations

10: Cytoband [Display Chart] 8 input genes in category / 8 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 8q22-q23 8q22-q23 4.616E-4 2.769E-3 7.526E-3 3.693E-3 1 2
2 9q32-q33 9q32-q33 6.923E-4 2.769E-3 7.526E-3 5.538E-3 1 3
3 7q21.1 7q21.1 1.845E-3 4.920E-3 1.337E-2 1.476E-2 1 8
4 2p24.1 2p24.1 5.527E-3 9.577E-3 2.603E-2 4.421E-2 1 24
5 20q12 20q12 5.986E-3 9.577E-3 2.603E-2 4.789E-2 1 26
6 12q22 12q22 9.654E-3 1.182E-2 3.212E-2
7.723E-2
 1 42
7 11q22.3 11q22.3 1.034E-2 1.182E-2 3.212E-2
8.272E-2
 1 45
8 12q13 12q13 1.627E-2 1.627E-2 4.422E-2
1.302E-1
 1 71
Show 3 more annotations

11: Transcription Factor Binding Site [Display Chart] 7 input genes in category / 49 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 7 input genes in category / 6 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 571 Syndecans genenames.org 1.395E-10 8.368E-10 2.050E-9 8.368E-10 3 4
2 573 Small leucine rich repeat proteoglycans genenames.org 4.609E-3 1.104E-2 2.704E-2 2.765E-2 1 12
3 631 Lipocalins genenames.org 7.288E-3 1.104E-2 2.704E-2 4.373E-2 1 19
4 471 CD molecules|Tumor necrosis factor superfamily genenames.org 9.140E-3 1.104E-2 2.704E-2
5.484E-2
 2 394
5 891 Matrix metallopeptidases genenames.org 9.199E-3 1.104E-2 2.704E-2
5.519E-2
 1 24

13: Coexpression [Display Chart] 8 input genes in category / 1070 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M596 Genes down-regulated in SiHa cells (cervical carcinoma) by stable expression of NOL7 [GeneID=51406] off a plasmid vector. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.144E-6 6.700E-3
5.061E-2
 8.715E-3 2 13
2 M12026 Genes up-regulated in FE-8 cells (fibroblasts) upon treatment with azacitidine [PubChem=9444]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.252E-5 6.700E-3
5.061E-2
 1.340E-2 2 16
3 M7659 Genes down-regulated in the in vitro follicular dendritic cells from peripheral lymph nodes: non-stimulated versus tretinoin [PubChem=444795] and Pam2CSK4 (96h). MSigDB C7: Immunologic Signatures (v6.0) 3.400E-5 9.780E-3
7.387E-2
 3.638E-2 3 199
4 19112599-Table2a Human Breast Ellsworth09 27genes GeneSigDB 3.656E-5 9.780E-3
7.387E-2
 3.912E-2 2 27
5 M11788 Selected genes down-regulated during invasion of lymphatic vessels during metastasis. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.552E-5 1.303E-2
9.845E-2
7.011E-2
 2 36
6 17909013-table2 Mouse Prostate Banach-Petrosky07 55genes GeneSigDB 7.309E-5 1.303E-2
9.845E-2
7.820E-2
 2 38
7 20460173-ImmPortCytokineReceptors Human Immune Kong10 308genes ImmPort CytokineReceptors GeneSigDB 1.186E-4 1.587E-2
1.199E-1
1.269E-1
 3 303
8 17409405-Table1a Human Breast Huper07 66genes BasalCells GeneSigDB 1.429E-4 1.587E-2
1.199E-1
1.529E-1
 2 53
9 M13422 Genes up-regulated in basal mammary epithelial cells compared to the luminal ones. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.484E-4 1.587E-2
1.199E-1
1.587E-1
 2 54
10 18794116-Table1 Mouse Lymphoma Clasper08 56genes GeneSigDB 1.484E-4 1.587E-2
1.199E-1
1.587E-1
 2 54
11 M1322 Genes down-regulated in 10T1/2 cells (multipotent mesoderma) by expression of SHH [GeneID=6469]. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.087E-4 1.963E-2
1.483E-1
2.233E-1
 2 64
12 M14808 Cluster 7: genes changed in primary keratinocytes by UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.356E-4 1.963E-2
1.483E-1
2.521E-1
 2 68
13 M1406 Genes up-regulated during epithelial to mesenchymal transition (EMT) induced by TGFB1 [GeneID=7040] in the EpH4 cells (mammary epithelium cell line transformed by HRAS [GeneID=3265]). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.569E-4 1.963E-2
1.483E-1
2.749E-1
 2 71
14 M3955 Integrin, VEGF, Wnt and TGFbeta signaling pathway genes up-regulated in PC-3 cells (prostate cancer) after knockdown of PDEF [GeneID=25803] by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.569E-4 1.963E-2
1.483E-1
2.749E-1
 2 71
15 M1685 Proteins secreted in co-culture of LKR-13 tumor cells (non-small cell lung cancer, NSCLC) and MHS stroma cells (macrophages). MSigDB C2: CGP Curated Gene Sets (v6.0) 3.022E-4 2.155E-2
1.628E-1
3.233E-1
 2 77
16 M4306 Genes down-regulated in HMLE cells (immortalized nontransformed mammary epithelium) after E-cadhedrin (CDH1) [GeneID=999] knockdown by RNAi. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.163E-4 2.784E-2
2.103E-1
4.455E-1
 3 464
17 M2352 Transcripts (mRNA molecules) rapidly degraded upon interaction with KHSRP [GeneID=8570]. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.091E-4 3.205E-2
2.420E-1
5.448E-1
 2 100
18 M1565 Genes up-regulated in MMEC cells (myometrial endothelium) by VEGFA [GeneID=7422] stimulation. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.935E-4 3.528E-2
2.665E-1
6.350E-1
 2 108
19 M6919 Genes down-regulated in B lymphocytes: control versus CpG oligodeoxynucleotide 1826. MSigDB C7: Immunologic Signatures (v6.0) 1.311E-3 4.580E-2
3.459E-1
1.000E0
 2 161
20 19351846-SuppTable2 Human Prostate Wang09 181genes GeneSigDB 1.311E-3 4.580E-2
3.459E-1
1.000E0
 2 161
21 M5656 Genes down-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute influenza infection versus PBMC from patients with acute S. aureus infection. MSigDB C7: Immunologic Signatures (v6.0) 1.581E-3 4.580E-2
3.459E-1
1.000E0
 2 177
22 M5663 Genes up-regulated in comparison of peripheral blood mononuclear cells (PBMC) from patients with acute infection: S. aureus versus S. pneumoniae. MSigDB C7: Immunologic Signatures (v6.0) 1.670E-3 4.580E-2
3.459E-1
1.000E0
 2 182
23 M17966 Genes that best predicted acute myeloid leukemia (AML) with the t(8;21) translocation producing the AML1-ETO fusion [GeneID=861;862]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.728E-3 4.580E-2
3.459E-1
1.000E0
 1 5
24 16618722-SuppTable2 Human InVitro Glesne06 217genes GeneSigDB 1.914E-3 4.580E-2
3.459E-1
1.000E0
 2 195
25 M8586 Genes up-regulated in CD4 [GeneID=920] T cells: healthy versus systemic lupus erythematosus (SLE). MSigDB C7: Immunologic Signatures (v6.0) 1.933E-3 4.580E-2
3.459E-1
1.000E0
 2 196
26 M5849 Genes down-regulated in comparison of monocytes treated with anti-TREM1 [GeneID=54210] versus monocytes treated with anti-TREM1 [GeneID=54210] and 5000 ng/ml LPS (TLR4 agonist). MSigDB C7: Immunologic Signatures (v6.0) 1.953E-3 4.580E-2
3.459E-1
1.000E0
 2 197
27 M5306 Genes up-regulated in comparison of untreated memory CD4 [GeneID=920] T cells from young donors versus those from old donors. MSigDB C7: Immunologic Signatures (v6.0) 1.953E-3 4.580E-2
3.459E-1
1.000E0
 2 197
28 M9527 Genes up-regulated in activated CD4 [GeneID=920] T cells expressing: wildtype versus mutant form of FOXP3 [GeneID=50943]. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 4.580E-2
3.459E-1
1.000E0
 2 199
29 M4059 Genes down-regulated in comparison of dendritic cells (DC) stimulated with LPS (TLR4 agonist) at 12 h versus DC cells stimulated with Gardiquimod (TLR7 agonist) at 12 h. MSigDB C7: Immunologic Signatures (v6.0) 1.992E-3 4.580E-2
3.459E-1
1.000E0
 2 199
30 M9434 Genes down-regulated in comparison between in vivo derived natural T reg (nTreg) and converted ex-iTreg (induced T reg that lost FOXP3 [GeneID=50943] expression). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
31 M9619 Genes down-regulated in T conv from: peripheral lymph nodes versus thymic precursors. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
32 M5891 Genes up-regulated in response to low oxygen levels (hypoxia). MSigDB H: Hallmark Gene Sets (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
33 M6306 Genes up-regulated in control macrophages: untreated versus primed by IFNG [GeneID=3458]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
34 M3608 Genes up-regulated in comparison of CD8 T cells at 0 h versus those at 72 h after stimulation with IL12. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
35 M6436 Genes down-regulated in NKT cells versus B2 B lymphocytes. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
36 M5930 Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. MSigDB H: Hallmark Gene Sets (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
37 M5476 Genes up-regulated in comparison of dendritic cells (DC) versus central memory CD4 [GeneID=920] T cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
38 M8605 Genes up-regulated in T cell activation mechanism that was NOS2 [GeneID=4843] dependent versus NOS2 [GeneID=4843] independent activation. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
39 M9121 Genes up-regulated in CD4 T conv over-expressing: FOXP3 [GeneID=50943] versus IKZF4 and FOXP3 [GeneID=64375;50943]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
40 M4838 Genes down-regulated in comparison of CD8 T cells versus NK cells. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
41 M9567 Genes down-regulated in KLRG1 low [GeneID=10219] CD8 T effector cells during infection: ID2 and BCL2L11 [GeneID=3398;10018] versus BCL2L11 [GeneID=10018] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
42 M9785 Genes down-regulated in resting CD8 T cells: wildtype versus MIR155 [GeneID=406947] knockout. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
43 M8222 Genes up-regulated in Pmel-1 CD8 T cells: naïve versus primed with cognate antigen (gp100) and IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
44 M6310 Genes down-regulated in macrophages primed by IFNG [GeneID=3458]: untreated versus stimulated by IFNG [GeneID=3458] for 3h. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
45 M8635 Genes down-regulated in bone marrow-derived dendritic cells treated with 1,3-beta-D-oligoglucan [PubChem=11375554]: low dose versus high dose. MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
46 M5937 Genes encoding proteins involved in glycolysis and gluconeogenesis. MSigDB H: Hallmark Gene Sets (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
47 M5427 Genes down-regulated in comparison of mast cells versus dendritic cells (DC). MSigDB C7: Immunologic Signatures (v6.0) 2.012E-3 4.580E-2
3.459E-1
1.000E0
 2 200
48 M10184 Genes up-regulated in monocytes by RUNX1-RUNX1T1 [GeneID=861;862] fusion. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.092E-3 4.663E-2
3.522E-1
1.000E0
 2 204
49 16207250-TableS2 Human Lung Ichikawa05 425genes GeneSigDB 2.215E-3 4.784E-2
3.613E-1
1.000E0
 2 210
50 16715129-SuppTable5 Human HeadandNeck Jarvinen06 223genes GeneSigDB 2.235E-3 4.784E-2
3.613E-1
1.000E0
 2 211
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 8 input genes in category / 943 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 4 input genes in category / 36 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M15032 MODULE 211 Genes in the cancer module 211. MSigDb: C4 - CM: Cancer Modules (v6.0) 4.377E-3 4.570E-2
1.908E-1
1.576E-1
 1 11
2 M3341 MODULE 311 Genes in the cancer module 311. MSigDb: C4 - CM: Cancer Modules (v6.0) 7.155E-3 4.570E-2
1.908E-1
2.576E-1
 1 18
3 M19072 MODULE 562 MMPs. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.344E-3 4.570E-2
1.908E-1
3.004E-1
 1 21
4 M17027 MODULE 573 Cell cycle regulators and carbohydrate transporters. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.927E-3 4.570E-2
1.908E-1
3.574E-1
 1 25
5 M956 MODULE 8 Genes in the cancer module 8. MSigDb: C4 - CM: Cancer Modules (v6.0) 9.955E-3 4.570E-2
1.908E-1
3.584E-1
 2 421
6 M5502 MODULE 371 Genes in the cancer module 371. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.032E-2 4.570E-2
1.908E-1
3.716E-1
 1 26
7 M10190 MODULE 52 Cell line expressed genes. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.051E-2 4.570E-2
1.908E-1
3.785E-1
 2 433
8 M13268 MODULE 210 Genes in the cancer module 210. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.111E-2 4.570E-2
1.908E-1
4.001E-1
 1 28
9 M5702 MODULE 24 Fetal liver genes - metabolism and xenobiotics. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.148E-2 4.570E-2
1.908E-1
4.132E-1
 2 453
10 M4193 GNF2 EGFR Neighborhood of EGFR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.269E-2 4.570E-2
1.908E-1
4.570E-1
 1 32
Show 5 more annotations

16: MicroRNA [Display Chart] 8 input genes in category / 238 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-660:PITA hsa-miR-660:PITA TOP PITA 1.474E-4 1.659E-2
1.004E-1
 3.508E-2 2 167
2 hsa-miR-6876-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.091E-4 1.659E-2
1.004E-1
 4.977E-2 2 199
3 hsa-miR-4476:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.091E-4 1.659E-2
1.004E-1
 4.977E-2 2 199
4 hsa-miR-3202:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.839E-4 2.049E-2
1.240E-1
9.138E-2
 2 270
5 hsa-miR-802:TargetScan hsa-miR-802 TargetScan 4.305E-4 2.049E-2
1.240E-1
1.025E-1
 2 286
6 hsa-miR-140-3p.2:TargetScan hsa-miR-140-3p.2 TargetScan 6.538E-4 2.504E-2
1.515E-1
1.556E-1
 2 353
7 hsa-miR-933:mirSVR lowEffct hsa-miR-933:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 7.449E-4 2.504E-2
1.515E-1
1.773E-1
 2 377
8 hsa-miR-553:mirSVR highEffct hsa-miR-553:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.418E-4 2.504E-2
1.515E-1
2.003E-1
 2 401
9 hsa-miR-668:mirSVR highEffct hsa-miR-668:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.030E-3 2.723E-2
1.648E-1
2.451E-1
 2 444
10 hsa-miR-126-3p.1:TargetScan hsa-miR-126-3p.1 TargetScan 2.655E-3 4.817E-2
2.915E-1
6.318E-1
 1 24
11 hsa-miR-564:PITA hsa-miR-564:PITA TOP PITA 4.201E-3 4.817E-2
2.915E-1
9.997E-1
 1 38
12 hsa-miR-652-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.642E-3 4.817E-2
2.915E-1
1.000E0
 1 42
13 hsa-miR-553:PITA hsa-miR-553:PITA TOP PITA 5.524E-3 4.817E-2
2.915E-1
1.000E0
 1 50
14 ACATATC,MIR-190:MSigDB ACATATC,MIR-190:MSigDB MSigDB 6.295E-3 4.817E-2
2.915E-1
1.000E0
 1 57
15 hsa-miR-6740-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.066E-3 4.817E-2
2.915E-1
1.000E0
 1 64
16 hsa-miR-7974:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.506E-3 4.817E-2
2.915E-1
1.000E0
 1 68
17 hsa-miR-6868-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.506E-3 4.817E-2
2.915E-1
1.000E0
 1 68
18 AGTCTTA,MIR-499:MSigDB AGTCTTA,MIR-499:MSigDB MSigDB 7.836E-3 4.817E-2
2.915E-1
1.000E0
 1 71
19 hsa-miR-4493:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.496E-3 4.817E-2
2.915E-1
1.000E0
 1 77
20 CAGGGTC,MIR-504:MSigDB CAGGGTC,MIR-504:MSigDB MSigDB 8.606E-3 4.817E-2
2.915E-1
1.000E0
 1 78
21 hsa-miR-4717-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.935E-3 4.817E-2
2.915E-1
1.000E0
 1 81
22 hsa-miR-450b-3p:PITA hsa-miR-450b-3p:PITA TOP PITA 9.375E-3 4.817E-2
2.915E-1
1.000E0
 1 85
23 hsa-miR-769-3p:PITA hsa-miR-769-3p:PITA TOP PITA 9.485E-3 4.817E-2
2.915E-1
1.000E0
 1 86
24 AGCTCCT,MIR-28:MSigDB AGCTCCT,MIR-28:MSigDB MSigDB 9.814E-3 4.817E-2
2.915E-1
1.000E0
 1 89
25 hsa-miR-126:mirSVR lowEffct hsa-miR-126:mirSVR conserved lowEffect-0.1-0.5 MicroRNA.org 1.003E-2 4.817E-2
2.915E-1
1.000E0
 1 91
26 hsa-miR-379-5p:TargetScan hsa-miR-379-5p TargetScan 1.014E-2 4.817E-2
2.915E-1
1.000E0
 1 92
27 hsa-miR-6730-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.025E-2 4.817E-2
2.915E-1
1.000E0
 1 93
28 CTGTTAC,MIR-194:MSigDB CTGTTAC,MIR-194:MSigDB MSigDB 1.102E-2 4.817E-2
2.915E-1
1.000E0
 1 100
29 hsa-miR-3616-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.124E-2 4.817E-2
2.915E-1
1.000E0
 1 102
30 hsa-miR-4733-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.135E-2 4.817E-2
2.915E-1
1.000E0
 1 103
31 hsa-miR-3186-5p:mirSVR highEffct hsa-miR-3186-5p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.157E-2 4.817E-2
2.915E-1
1.000E0
 1 105
32 hsa-miR-4753-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.201E-2 4.817E-2
2.915E-1
1.000E0
 1 109
33 hsa-miR-1264:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.212E-2 4.817E-2
2.915E-1
1.000E0
 1 110
34 hsa-miR-877:PITA hsa-miR-877:PITA TOP PITA 1.256E-2 4.817E-2
2.915E-1
1.000E0
 1 114
35 hsa-miR-199a-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.256E-2 4.817E-2
2.915E-1
1.000E0
 1 114
36 hsa-miR-564:mirSVR highEffct hsa-miR-564:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.267E-2 4.817E-2
2.915E-1
1.000E0
 1 115
37 hsa-miR-449b-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.288E-2 4.817E-2
2.915E-1
1.000E0
 1 117
38 ACAGGGT,MIR-10B:MSigDB ACAGGGT,MIR-10B:MSigDB MSigDB 1.321E-2 4.817E-2
2.915E-1
1.000E0
 1 120
39 ACAGGGT,MIR-10A:MSigDB ACAGGGT,MIR-10A:MSigDB MSigDB 1.321E-2 4.817E-2
2.915E-1
1.000E0
 1 120
40 hsa-miR-548an:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.365E-2 4.817E-2
2.915E-1
1.000E0
 1 124
41 hsa-miR-4691-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.365E-2 4.817E-2
2.915E-1
1.000E0
 1 124
42 hsa-miR-2277:mirSVR highEffct hsa-miR-2277:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.376E-2 4.817E-2
2.915E-1
1.000E0
 1 125
43 hsa-miR-4480:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.376E-2 4.817E-2
2.915E-1
1.000E0
 1 125
44 hsa-miR-577:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.420E-2 4.817E-2
2.915E-1
1.000E0
 1 129
45 hsa-miR-6732-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.431E-2 4.817E-2
2.915E-1
1.000E0
 1 130
46 hsa-miR-488-3p:Functional MTI Functional MTI miRTarbase 1.442E-2 4.817E-2
2.915E-1
1.000E0
 1 131
47 hsa-miR-1245:PITA hsa-miR-1245:PITA TOP PITA 1.453E-2 4.817E-2
2.915E-1
1.000E0
 1 132
48 hsa-miR-1273c:mirSVR highEffct hsa-miR-1273c:mirSVR nonconserved highEffect-0.5 MicroRNA.org 1.453E-2 4.817E-2
2.915E-1
1.000E0
 1 132
49 hsa-miR-4632-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.463E-2 4.817E-2
2.915E-1
1.000E0
 1 133
50 hsa-miR-7843-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.463E-2 4.817E-2
2.915E-1
1.000E0
 1 133
Show 45 more annotations

17: Drug [Display Chart] 8 input genes in category / 2630 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000123961 mannosamine Stitch 3.310E-11 7.952E-8 6.721E-7 8.704E-8 5 84
2 CID000024759 hyaluronan Stitch 6.047E-11 7.952E-8 6.721E-7 1.590E-7 6 263
3 CID000024766 chondroitin sulfate Stitch 9.155E-10 8.026E-7 6.783E-6 2.408E-6 6 413
4 CID000032756 dermatan sulfate Stitch 4.333E-9 2.849E-6 2.408E-5 1.140E-5 5 220
5 CID000019654 chlorate Stitch 2.692E-8 1.416E-5 1.197E-4 7.080E-5 4 103
6 CID000001599 NSC3056 Stitch 8.510E-8 3.489E-5 2.949E-4 2.238E-4 4 137
7 ctd:D006493 Heparin CTD 9.285E-8 3.489E-5 2.949E-4 2.442E-4 4 140
8 ctd:C484302 apratastat CTD 3.220E-7 9.093E-5 7.685E-4 8.468E-4 2 3
9 ctd:C499807 (2R, 3S)-2-(((4-(2-butynyloxy)phenyl)sulfonyl)amino)-N,3-dihydroxybutanamide CTD 3.220E-7 9.093E-5 7.685E-4 8.468E-4 2 3
10 CID000107810 FR139317 Stitch 3.457E-7 9.093E-5 7.685E-4 9.093E-4 3 43
11 CID000004242 NSC-343257 Stitch 6.676E-7 1.520E-4 1.285E-3 1.756E-3 4 229
12 CID003083599 Sulf Stitch 6.936E-7 1.520E-4 1.285E-3 1.824E-3 3 54
13 CID000000229 arabinopyranose Stitch 1.125E-6 2.276E-4 1.924E-3 2.959E-3 4 261
14 ctd:C492546 GW280264X CTD 1.609E-6 3.023E-4 2.555E-3 4.232E-3 2 6
15 CID000074493 D-galactosamine hydrochloride Stitch 2.038E-6 3.350E-4 2.831E-3 5.360E-3 3 77
16 CID000015348 2-amino-5-methylpyridine Stitch 2.038E-6 3.350E-4 2.831E-3 5.360E-3 3 77
17 CID000004777 NSC139075 Stitch 2.288E-6 3.539E-4 2.991E-3 6.017E-3 3 80
18 CID005288693 NSC 714187 Stitch 2.748E-6 4.015E-4 3.394E-3 7.227E-3 3 85
19 CID000003961 losartan Stitch 4.904E-6 6.788E-4 5.737E-3 1.290E-2 4 378
20 ctd:C092152 N-((2-(hydroxyaminocarbonyl)methyl)-4-methylpentanoyl)-3-(2'-naphthyl)alanylalanine, 2-aminoethylamide CTD 7.072E-6 9.300E-4 7.861E-3 1.860E-2 2 12
21 CID004369438 x s2 Stitch 8.357E-6 1.047E-3 8.846E-3 2.198E-2 2 13
22 CID000072361 glucosamine 6-sulfate Stitch 2.033E-5 2.430E-3 2.054E-2
5.347E-2
 2 20
23 CID000002287 NSC381866 Stitch 2.207E-5 2.524E-3 2.133E-2
5.805E-2
 3 170
24 2530 UP Terazosin hydrochloride [63590-64-7]; Up 200; 9.4uM; HL60; HT HG-U133A Broad Institute CMAP Up 3.376E-5 3.699E-3 3.127E-2
8.879E-2
 3 196
25 4073 UP Beta-sistosterol [83-46-5]; Up 200; 9.6uM; PC3; HT HG-U133A Broad Institute CMAP Up 3.586E-5 3.772E-3 3.188E-2
9.430E-2
 3 200
26 CID003530978 AC1MS9WM Stitch 3.751E-5 3.795E-3 3.207E-2
9.866E-2
 2 27
27 ctd:C503753 Indolinone A CTD 6.350E-5 6.186E-3
5.228E-2
1.670E-1
 2 35
28 CID000231825 Ic 21 Stitch 6.722E-5 6.314E-3
5.337E-2
1.768E-1
 2 36
29 CID000082482 p-Nitrophenyl alpha-D-xyloside Stitch 8.742E-5 7.928E-3
6.701E-2
2.299E-1
 2 41
30 CID009543520 triphosphoinositide Stitch 9.047E-5 7.928E-3
6.701E-2
2.379E-1
 3 273
31 ctd:D003345 Corticosterone CTD 9.345E-5 7.928E-3
6.701E-2
2.458E-1
 3 276
32 CID002867154 AC1MF7BR Stitch 1.008E-4 8.285E-3
7.002E-2
2.651E-1
 2 44
33 CID000004984 AC1L2DAI Stitch 1.244E-4 9.916E-3
8.381E-2
3.272E-1
 3 304
34 CID006518178 AC1O745K Stitch 1.304E-4 1.009E-2
8.525E-2
3.429E-1
 2 50
35 ctd:D005944 Glucosamine CTD 1.356E-4 1.019E-2
8.614E-2
3.567E-1
 3 313
36 ctd:D017382 Reactive Oxygen Species CTD 1.530E-4 1.118E-2
9.446E-2
4.023E-1
 3 326
37 CID000445839 AC1L9INI Stitch 1.818E-4 1.293E-2
1.092E-1
4.782E-1
 2 59
38 CID011840957 LG 5 Stitch 1.881E-4 1.302E-2
1.100E-1
4.946E-1
 2 60
39 CID000119031 marimastat Stitch 2.417E-4 1.553E-2
1.312E-1
6.357E-1
 2 68
40 CID000002833 colchine Stitch 2.461E-4 1.553E-2
1.312E-1
6.472E-1
 3 383
41 CID000028810 2-chlorobenzyl alcohol Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
42 CID000092959 3-hydroxy-3-phenylpropanoate Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
43 CID000124821 EFMN Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
44 CID000123769 Tc-ethylenedicysteine Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
45 CID000196312 PAHIDA Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
46 CID000124142 3-deoxy-4-sulphohexosulose Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
47 CID000169078 7,8-dihydro-6-hydroxylumazine Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
48 CID000066122 Nf 477 Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
49 CID000008281 sulfadicramide Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
50 CID000064775 pinacidil pyridine-N-oxide Stitch 3.502E-4 1.553E-2
1.312E-1
9.212E-1
 1 1
Show 45 more annotations

18: Disease [Display Chart] 7 input genes in category / 436 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0344911 Left ventricular dilatation DisGeNET BeFree 5.750E-6 2.507E-3 1.669E-2 2.507E-3 2 9
2 C0085404 POEMS Syndrome DisGeNET BeFree 1.245E-5 2.714E-3 1.806E-2 5.427E-3 2 13
3 C0206702 Klatskin Tumor DisGeNET BeFree 4.029E-5 4.790E-3 3.188E-2 1.757E-2 2 23
4 C0023223 Leg Ulcer DisGeNET BeFree 4.395E-5 4.790E-3 3.188E-2 1.916E-2 2 24
5 C0011884 Diabetic Retinopathy DisGeNET Curated 6.157E-5 5.369E-3 3.574E-2 2.684E-2 3 199
6 C0598935 Tumor Initiation DisGeNET BeFree 1.009E-4 6.302E-3 4.194E-2 4.401E-2 3 235
7 C0037286 Skin Neoplasms DisGeNET Curated 1.075E-4 6.302E-3 4.194E-2 4.685E-2 3 240
8 C0155626 Acute myocardial infarction DisGeNET BeFree 1.156E-4 6.302E-3 4.194E-2
5.041E-2
 3 246
9 C0205824 Liposarcoma, Dedifferentiated DisGeNET Curated 1.366E-4 6.617E-3 4.404E-2
5.955E-2
 2 42
10 C0149521 Pancreatitis, Chronic DisGeNET Curated 1.807E-4 7.363E-3 4.901E-2
7.877E-2
 3 286
11 C0346990 Carcinomatosis of peritoneal cavity DisGeNET BeFree 1.863E-4 7.363E-3 4.901E-2
8.122E-2
 2 49
12 C0020490 Hyperopia DisGeNET Curated 2.264E-4 7.363E-3 4.901E-2
9.873E-2
 2 54
13 C0154830 Proliferative diabetic retinopathy DisGeNET BeFree 3.184E-4 7.363E-3 4.901E-2
1.388E-1
 2 64
14 C1800706 Idiopathic Pulmonary Fibrosis DisGeNET Curated 3.250E-4 7.363E-3 4.901E-2
1.417E-1
 3 349
15 C0034069 Pulmonary Fibrosis DisGeNET Curated 4.015E-4 7.363E-3 4.901E-2
1.751E-1
 3 375
16 C0038358 Gastric ulcer DisGeNET Curated 4.257E-4 7.363E-3 4.901E-2
1.856E-1
 2 74
17 C0346057 Cutaneous neurofibroma DisGeNET BeFree 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
18 C0521626 Fibrosis of urinary bladder DisGeNET BeFree 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
19 C3826591 Chest--Diseases DisGeNET BeFree 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
20 C1857574 CORNEA PLANA 2 DisGeNET Curated 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
21 OMIN:217300 CORNEA PLANA 2; CNA2 OMIM 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
22 cv:C1842342 Deafness, autosomal recessive 39 Clinical Variations 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
23 C1842342 DEAFNESS, AUTOSOMAL RECESSIVE 39 (disorder) DisGeNET Curated 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
24 OMIN:608265 DEAFNESS, AUTOSOMAL RECESSIVE 39; DFNB39 OMIM 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
25 cv:C1857574 Cornea plana 2 Clinical Variations 4.320E-4 7.363E-3 4.901E-2
1.883E-1
 1 1
26 C0085136 Central Nervous System Neoplasms DisGeNET Curated 4.608E-4 7.363E-3 4.901E-2
2.009E-1
 2 77
27 C0151747 Renal tubular disorder DisGeNET Curated 4.608E-4 7.363E-3 4.901E-2
2.009E-1
 2 77
28 C0085655 Polymyositis DisGeNET Curated 4.729E-4 7.363E-3 4.901E-2
2.062E-1
 2 78
29 C0399440 Hereditary gingival fibromatosis DisGeNET Curated 6.431E-4 9.384E-3
6.246E-2
2.804E-1
 2 91
30 C0032927 Precancerous Conditions DisGeNET Curated 6.457E-4 9.384E-3
6.246E-2
2.815E-1
 3 441
31 C0271183 Severe myopia DisGeNET Curated 6.860E-4 9.415E-3
6.267E-2
2.991E-1
 2 94
32 C0205647 Follicular adenoma DisGeNET BeFree 8.229E-4 9.415E-3
6.267E-2
3.588E-1
 2 103
33 C2985220 Anaplastic Medulloblastoma DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
34 C0265000 Ulcer of artery DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
35 C3711531 Hdl Deficiency, Type 2 DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
36 C0267778 Adhesion of intestine DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
37 C2748502 CORNEAL DYSTROPHY, POSTERIOR AMORPHOUS DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
38 C0234253 Rest pain DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
39 C0151864 Disorder of pregnancy DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
40 C0333161 Pseudocyst DisGeNET BeFree 8.638E-4 9.415E-3
6.267E-2
3.766E-1
 1 2
41 C0268621 Hepatic methionine adenosyltransferase deficiency DisGeNET Curated 8.877E-4 9.439E-3
6.283E-2
3.870E-1
 2 107
42 C0022578 Keratoconus DisGeNET Curated 1.060E-3 1.100E-2
7.324E-2
4.622E-1
 2 117
43 C3887486 Interstitial lung fibrosis DisGeNET BeFree 1.247E-3 1.177E-2
7.832E-2
5.438E-1
 2 127
44 C4266441 Thyroid tumor metastasis DisGeNET BeFree 1.295E-3 1.177E-2
7.832E-2
5.648E-1
 1 3
45 C1835450 Leri pleonosteosis DisGeNET BeFree 1.295E-3 1.177E-2
7.832E-2
5.648E-1
 1 3
46 C0302872 MYELOMA, ENDOTHELIAL DisGeNET BeFree 1.295E-3 1.177E-2
7.832E-2
5.648E-1
 1 3
47 C1302363 Dysplasia of colon DisGeNET BeFree 1.295E-3 1.177E-2
7.832E-2
5.648E-1
 1 3
48 C1096274 Corneal thinning DisGeNET Curated 1.295E-3 1.177E-2
7.832E-2
5.648E-1
 1 3
49 C0027626 Neoplasm Invasiveness DisGeNET Curated 1.577E-3 1.397E-2
9.298E-2
6.878E-1
 2 143
50 C0879257 Hereditary Papillary Renal Carcinoma DisGeNET BeFree 1.727E-3 1.397E-2
9.298E-2
7.529E-1
 1 4
Show 45 more annotations