Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc191_5, positive side

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1: GO: Molecular Function [Display Chart] 5 input genes in category / 9 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0032561 guanyl ribonucleotide binding 9.397E-5 2.930E-4 8.289E-4 8.457E-4 3 399
2 GO:0019001 guanyl nucleotide binding 9.467E-5 2.930E-4 8.289E-4 8.520E-4 3 400
3 GO:0019003 GDP binding 9.767E-5 2.930E-4 8.289E-4 8.791E-4 2 59
4 GO:0003924 GTPase activity 1.553E-3 3.197E-3 9.045E-3 1.398E-2 2 236
5 GO:0031625 ubiquitin protein ligase binding 2.071E-3 3.197E-3 9.045E-3 1.864E-2 2 273
6 GO:0044389 ubiquitin-like protein ligase binding 2.132E-3 3.197E-3 9.045E-3 1.918E-2 2 277
7 GO:0005525 GTP binding 3.930E-3 5.053E-3 1.429E-2 3.537E-2 2 378
8 GO:0043531 ADP binding 1.094E-2 1.231E-2 3.481E-2
9.845E-2
 1 41
9 GO:0051117 ATPase binding 2.310E-2 2.310E-2
6.534E-2
2.079E-1
 1 87
Show 4 more annotations

2: GO: Biological Process [Display Chart] 5 input genes in category / 152 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0090141 positive regulation of mitochondrial fission 9.986E-13 1.518E-10 8.506E-10 1.518E-10 4 14
2 GO:0090140 regulation of mitochondrial fission 3.052E-12 2.320E-10 1.300E-9 4.639E-10 4 18
3 GO:0000266 mitochondrial fission 2.732E-11 1.384E-9 7.757E-9 4.153E-9 4 30
4 GO:0016559 peroxisome fission 1.114E-9 3.388E-8 1.898E-7 1.694E-7 3 10
5 GO:0043653 mitochondrial fragmentation involved in apoptotic process 1.114E-9 3.388E-8 1.898E-7 1.694E-7 3 10
6 GO:0070584 mitochondrion morphogenesis 1.058E-8 2.680E-7 1.502E-6 1.608E-6 3 20
7 GO:0090314 positive regulation of protein targeting to membrane 2.133E-8 4.053E-7 2.271E-6 3.242E-6 3 25
8 GO:0008053 mitochondrial fusion 2.133E-8 4.053E-7 2.271E-6 3.242E-6 3 25
9 GO:0010822 positive regulation of mitochondrion organization 3.250E-8 5.488E-7 3.076E-6 4.940E-6 4 169
10 GO:0090313 regulation of protein targeting to membrane 5.057E-8 7.687E-7 4.308E-6 7.687E-6 3 33
11 GO:0007031 peroxisome organization 6.065E-8 8.381E-7 4.697E-6 9.219E-6 3 35
12 GO:0010821 regulation of mitochondrion organization 1.028E-7 1.202E-6 6.734E-6 1.562E-5 4 225
13 GO:0061025 membrane fusion 1.028E-7 1.202E-6 6.734E-6 1.562E-5 4 225
14 GO:1900063 regulation of peroxisome organization 1.730E-7 1.878E-6 1.053E-5 2.629E-5 2 3
15 GO:0001836 release of cytochrome c from mitochondria 3.328E-7 3.373E-6 1.890E-5 5.059E-5 3 61
16 GO:0008637 apoptotic mitochondrial changes 3.214E-6 3.054E-5 1.711E-4 4.886E-4 3 129
17 GO:2001235 positive regulation of apoptotic signaling pathway 1.079E-5 8.769E-5 4.915E-4 1.641E-3 3 193
18 GO:0070585 protein localization to mitochondrion 1.079E-5 8.769E-5 4.915E-4 1.641E-3 3 193
19 GO:0006612 protein targeting to membrane 1.096E-5 8.769E-5 4.915E-4 1.666E-3 3 194
20 GO:0048284 organelle fusion 1.237E-5 9.404E-5 5.270E-4 1.881E-3 3 202
21 GO:0090200 positive regulation of release of cytochrome c from mitochondria 2.335E-5 1.690E-4 9.470E-4 3.549E-3 2 29
22 GO:0090316 positive regulation of intracellular protein transport 2.950E-5 2.038E-4 1.142E-3 4.484E-3 3 270
23 GO:0051260 protein homooligomerization 4.041E-5 2.671E-4 1.497E-3 6.142E-3 3 300
24 GO:1903533 regulation of protein targeting 4.808E-5 3.045E-4 1.707E-3 7.309E-3 3 318
25 GO:0090199 regulation of release of cytochrome c from mitochondria 5.941E-5 3.612E-4 2.024E-3 9.030E-3 2 46
26 GO:0090150 establishment of protein localization to membrane 7.986E-5 4.668E-4 2.616E-3 1.214E-2 3 377
27 GO:1903829 positive regulation of cellular protein localization 8.370E-5 4.712E-4 2.641E-3 1.272E-2 3 383
28 GO:0032388 positive regulation of intracellular transport 9.244E-5 5.018E-4 2.812E-3 1.405E-2 3 396
29 GO:0033157 regulation of intracellular protein transport 9.739E-5 5.104E-4 2.861E-3 1.480E-2 3 403
30 GO:2001233 regulation of apoptotic signaling pathway 1.018E-4 5.142E-4 2.882E-3 1.547E-2 3 409
31 GO:2001244 positive regulation of intrinsic apoptotic signaling pathway 1.049E-4 5.142E-4 2.882E-3 1.594E-2 2 61
32 GO:0003374 dynamin family protein polymerization involved in mitochondrial fission 2.685E-4 1.237E-3 6.931E-3 4.081E-2 1 1
33 GO:0003373 dynamin family protein polymerization involved in membrane fission 2.685E-4 1.237E-3 6.931E-3 4.081E-2 1 1
34 GO:0090149 mitochondrial membrane fission 5.369E-4 2.332E-3 1.307E-2
8.161E-2
 1 2
35 GO:0001928 regulation of exocyst assembly 5.369E-4 2.332E-3 1.307E-2
8.161E-2
 1 2
36 GO:0006626 protein targeting to mitochondrion 6.684E-4 2.822E-3 1.582E-2
1.016E-1
 2 154
37 GO:0016241 regulation of macroautophagy 7.034E-4 2.885E-3 1.617E-2
1.069E-1
 2 158
38 GO:2001242 regulation of intrinsic apoptotic signaling pathway 7.212E-4 2.885E-3 1.617E-2
1.096E-1
 2 160
39 GO:0060178 regulation of exocyst localization 8.053E-4 3.139E-3 1.759E-2
1.224E-1
 1 3
40 GO:0032104 regulation of response to extracellular stimulus 9.521E-4 3.530E-3 1.978E-2
1.447E-1
 2 184
41 GO:0032107 regulation of response to nutrient levels 9.521E-4 3.530E-3 1.978E-2
1.447E-1
 2 184
42 GO:0072655 establishment of protein localization to mitochondrion 9.936E-4 3.596E-3 2.015E-2
1.510E-1
 2 188
43 GO:0001927 exocyst assembly 1.074E-3 3.795E-3 2.127E-2
1.632E-1
 1 4
44 GO:0061726 mitochondrion disassembly 1.214E-3 4.102E-3 2.299E-2
1.846E-1
 2 208
45 GO:0000422 autophagy of mitochondrion 1.214E-3 4.102E-3 2.299E-2
1.846E-1
 2 208
46 GO:0090148 membrane fission 1.342E-3 4.434E-3 2.485E-2
2.040E-1
 1 5
47 GO:1903008 organelle disassembly 1.444E-3 4.670E-3 2.617E-2
2.195E-1
 2 227
48 GO:0010506 regulation of autophagy 1.946E-3 6.163E-3 3.454E-2
2.958E-1
 2 264
49 GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration 2.146E-3 6.658E-3 3.731E-2
3.262E-1
 1 8
50 GO:0006839 mitochondrial transport 2.217E-3 6.740E-3 3.777E-2
3.370E-1
 2 282
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 5 input genes in category / 35 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0005777 peroxisome 1.468E-8 2.569E-7 1.065E-6 5.137E-7 4 142
2 GO:0042579 microbody 1.468E-8 2.569E-7 1.065E-6 5.137E-7 4 142
3 GO:0005741 mitochondrial outer membrane 3.105E-8 3.623E-7 1.502E-6 1.087E-6 4 171
4 GO:0031968 organelle outer membrane 5.378E-8 4.336E-7 1.798E-6 1.882E-6 4 196
5 GO:0019867 outer membrane 6.194E-8 4.336E-7 1.798E-6 2.168E-6 4 203
6 GO:0032592 integral component of mitochondrial membrane 7.835E-5 4.215E-4 1.748E-3 2.742E-3 2 54
7 GO:0098573 intrinsic component of mitochondrial membrane 8.430E-5 4.215E-4 1.748E-3 2.950E-3 2 56
8 GO:0008021 synaptic vesicle 6.549E-4 2.865E-3 1.188E-2 2.292E-2 2 156
9 GO:0070382 exocytic vesicle 7.952E-4 3.093E-3 1.282E-2 2.783E-2 2 172
10 GO:0044455 mitochondrial membrane part 9.590E-4 3.356E-3 1.392E-2 3.356E-2 2 189
11 GO:0031301 integral component of organelle membrane 2.133E-3 6.786E-3 2.814E-2
7.464E-2
 2 283
12 GO:0031300 intrinsic component of organelle membrane 2.330E-3 6.796E-3 2.818E-2
8.156E-2
 2 296
13 GO:0098793 presynapse 3.079E-3 8.076E-3 3.349E-2
1.078E-1
 2 341
14 GO:0031231 intrinsic component of peroxisomal membrane 3.667E-3 8.076E-3 3.349E-2
1.284E-1
 1 14
15 GO:0005779 integral component of peroxisomal membrane 3.667E-3 8.076E-3 3.349E-2
1.284E-1
 1 14
16 GO:0030133 transport vesicle 3.692E-3 8.076E-3 3.349E-2
1.292E-1
 2 374
17 GO:0000145 exocyst 4.713E-3 9.704E-3 4.024E-2
1.650E-1
 1 18
18 GO:0031307 integral component of mitochondrial outer membrane 5.497E-3 1.061E-2 4.399E-2
1.924E-1
 1 21
19 GO:0031306 intrinsic component of mitochondrial outer membrane 5.758E-3 1.061E-2 4.399E-2
2.015E-1
 1 22
20 GO:0005778 peroxisomal membrane 1.512E-2 2.420E-2
1.003E-1
5.293E-1
 1 58
21 GO:0031903 microbody membrane 1.512E-2 2.420E-2
1.003E-1
5.293E-1
 1 58
22 GO:0099501 exocytic vesicle membrane 1.590E-2 2.420E-2
1.003E-1
5.565E-1
 1 61
23 GO:0030672 synaptic vesicle membrane 1.590E-2 2.420E-2
1.003E-1
5.565E-1
 1 61
24 GO:0005905 clathrin-coated pit 1.797E-2 2.621E-2
1.087E-1
6.290E-1
 1 69
25 GO:0005776 autophagosome 2.133E-2 2.986E-2
1.238E-1
7.465E-1
 1 82
26 GO:0044438 microbody part 2.493E-2 3.232E-2
1.340E-1
8.726E-1
 1 96
27 GO:0044439 peroxisomal part 2.493E-2 3.232E-2
1.340E-1
8.726E-1
 1 96
28 GO:0005903 brush border 3.339E-2 4.163E-2
1.726E-1
1.000E0
 1 129
29 GO:0030496 midbody 3.543E-2 4.163E-2
1.726E-1
1.000E0
 1 137
30 GO:0044448 cell cortex part 3.568E-2 4.163E-2
1.726E-1
1.000E0
 1 138
31 GO:0030658 transport vesicle membrane 4.077E-2 4.603E-2
1.909E-1
1.000E0
 1 158
32 GO:0098862 cluster of actin-based cell projections 4.507E-2 4.930E-2
2.044E-1
1.000E0
 1 175
Show 27 more annotations

4: Human Phenotype [Display Chart] 2 input genes in category / 45 annotations before applied cutoff / 4707 genes in category

No results to display

5: Mouse Phenotype [Display Chart] 3 input genes in category / 134 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0011704 decreased fibroblast proliferation 4.798E-4 3.763E-2
2.062E-1
6.429E-2
 2 132
2 MP:0014010 abnormal peroxisome morphology 5.794E-4 3.763E-2
2.062E-1
7.764E-2
 1 2
3 MP:0011702 abnormal fibroblast proliferation 8.425E-4 3.763E-2
2.062E-1
1.129E-1
 2 175

6: Domain [Display Chart] 5 input genes in category / 38 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 IPR030556 DNM1L InterPro 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
2 IPR016543 Fis1 InterPro 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
3 PF14852 Fis1 TPR N Pfam 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
4 IPR028061 Fis1 TPR C InterPro 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
5 PF14853 Fis1 TPR C Pfam 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
6 IPR028058 Fis1 TPR N InterPro 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
7 IPR033745 Fis1 cytosol InterPro 2.669E-4 1.449E-3 6.125E-3 1.014E-2 1 1
8 PF05644 Miff Pfam 5.337E-4 2.028E-3 8.574E-3 2.028E-2 1 2
9 IPR028412 Ral InterPro 5.337E-4 2.028E-3 8.574E-3 2.028E-2 1 2
10 IPR008518 FATE/Miff/Tango-11 InterPro 5.337E-4 2.028E-3 8.574E-3 2.028E-2 1 2
11 PF02212 GED Pfam 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
12 PS51388 GED PROSITE 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
13 PF01031 Dynamin M Pfam 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
14 IPR020850 GED dom InterPro 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
15 IPR000375 Dynamin central InterPro 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
16 IPR003130 GED InterPro 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
17 SM00302 GED SMART 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
18 IPR019762 Dynamin GTPase CS InterPro 1.600E-3 3.379E-3 1.428E-2
6.082E-2
 1 6
19 SM00053 DYNc SMART 1.867E-3 3.547E-3 1.500E-2
7.094E-2
 1 7
20 PS00410 G DYNAMIN 1 PROSITE 1.867E-3 3.547E-3 1.500E-2
7.094E-2
 1 7
21 PF03281 Mab-21 Pfam 3.199E-3 5.285E-3 2.234E-2
1.216E-1
 1 12
22 SM01265 Mab-21 SMART 3.199E-3 5.285E-3 2.234E-2
1.216E-1
 1 12
23 IPR024810 Mab-21 dom InterPro 3.199E-3 5.285E-3 2.234E-2
1.216E-1
 1 12
24 IPR030381 G DYNAMIN dom InterPro 3.731E-3 5.425E-3 2.294E-2
1.418E-1
 1 14
25 PS51718 G DYNAMIN 2 PROSITE 3.731E-3 5.425E-3 2.294E-2
1.418E-1
 1 14
26 PF00350 Dynamin N Pfam 3.997E-3 5.425E-3 2.294E-2
1.519E-1
 1 15
27 IPR001401 Dynamin GTPase InterPro 3.997E-3 5.425E-3 2.294E-2
1.519E-1
 1 15
28 IPR022812 Dynamin SF InterPro 3.997E-3 5.425E-3 2.294E-2
1.519E-1
 1 15
29 PS51421 RAS PROSITE 9.307E-3 1.220E-2
5.156E-2
3.537E-1
 1 35
30 IPR020849 Small GTPase Ras InterPro 9.837E-3 1.246E-2
5.268E-2
3.738E-1
 1 37
31 PF00071 Ras Pfam 3.578E-2 4.385E-2
1.854E-1
1.000E0
 1 136
32 IPR013026 TPR-contain dom InterPro 3.940E-2 4.622E-2
1.954E-1
1.000E0
 1 150
33 IPR001806 Small GTPase InterPro 4.198E-2 4.622E-2
1.954E-1
1.000E0
 1 160
34 PS50005 TPR PROSITE 4.327E-2 4.622E-2
1.954E-1
1.000E0
 1 165
35 PS50293 TPR REGION PROSITE 4.327E-2 4.622E-2
1.954E-1
1.000E0
 1 165
36 IPR005225 Small GTP-bd dom InterPro 4.379E-2 4.622E-2
1.954E-1
1.000E0
 1 167
Show 31 more annotations

7: Pathway [Display Chart] 3 input genes in category / 18 annotations before applied cutoff / 12450 genes in category

No results to display

8: Pubmed [Display Chart] 5 input genes in category / 436 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 21701560 Human MIEF1 recruits Drp1 to mitochondrial outer membranes and promotes mitochondrial fusion rather than fission. Pubmed 5.640E-17 2.459E-14 1.637E-13 2.459E-14 4 4
2 23283981 Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission. Pubmed 2.820E-16 6.148E-14 4.092E-13 1.230E-13 4 5
3 23921378 Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. Pubmed 1.974E-15 2.869E-13 1.910E-12 8.607E-13 4 7
4 18353969 The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells. Pubmed 1.077E-12 1.174E-10 7.814E-10 4.696E-10 3 3
5 21149567 Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. Pubmed 4.308E-12 3.130E-10 2.084E-9 1.878E-9 3 4
6 23530241 Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission. Pubmed 4.308E-12 3.130E-10 2.084E-9 1.878E-9 3 4
7 22595523 PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission. Pubmed 1.371E-8 5.435E-7 3.617E-6 5.978E-6 2 2
8 12861026 The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Pubmed 1.371E-8 5.435E-7 3.617E-6 5.978E-6 2 2
9 25822260 Mitochondrial dynamics protein Drp1 is overexpressed in oncocytic thyroid tumors and regulates cancer cell migration. Pubmed 1.371E-8 5.435E-7 3.617E-6 5.978E-6 2 2
10 26578513 Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity. Pubmed 1.371E-8 5.435E-7 3.617E-6 5.978E-6 2 2
11 22340708 Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer's disease. Pubmed 1.371E-8 5.435E-7 3.617E-6 5.978E-6 2 2
12 20179104 Decreased expression of Drp1 and Fis1 mediates mitochondrial elongation in senescent cells and enhances resistance to oxidative stress through PINK1. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
13 15356267 Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
14 16010987 Regulation of Ca2+-induced permeability transition by Bcl-2 is antagonized by Drpl and hFis1. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
15 26903540 Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
16 28262828 SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
17 27660309 The role of Drp1 adaptor proteins MiD49 and MiD51 in mitochondrial fission: implications for human disease. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
18 21508961 MiD49 and MiD51, new components of the mitochondrial fission machinery. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
19 17408615 Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
20 27076521 Cooperative and independent roles of the Drp1 adaptors Mff, MiD49 and MiD51 in mitochondrial fission. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
21 23284813 TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
22 22639965 Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
23 20428767 Specific mitochondrial calcium overload induces mitochondrial fission in prostate cancer cells. Pubmed 4.113E-8 7.797E-7 5.190E-6 1.793E-5 2 3
24 24508339 The mitochondrial fission receptor MiD51 requires ADP as a cofactor. Pubmed 8.226E-8 1.379E-6 9.181E-6 3.586E-5 2 4
25 24515348 Structural and functional analysis of MiD51, a dynamin receptor required for mitochondrial fission. Pubmed 8.226E-8 1.379E-6 9.181E-6 3.586E-5 2 4
26 23713734 Mitochondrial fusion and fission proteins expression dynamically change in a murine model of amyotrophic lateral sclerosis. Pubmed 8.226E-8 1.379E-6 9.181E-6 3.586E-5 2 4
27 20826455 PEX11 family members are membrane elongation factors that coordinate peroxisome proliferation and maintenance. Pubmed 1.371E-7 2.214E-6 1.473E-5 5.977E-5 2 5
28 16874301 A novel mitochondrial ubiquitin ligase plays a critical role in mitochondrial dynamics. Pubmed 2.056E-7 3.091E-6 2.058E-5 8.965E-5 2 6
29 27852436 Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1. Pubmed 2.056E-7 3.091E-6 2.058E-5 8.965E-5 2 6
30 26472072 Adult mice expressing a Braf Q241R mutation on an ICR/CD-1 background exhibit a cardio-facio-cutaneous syndrome phenotype. Pubmed 6.167E-7 8.963E-6 5.966E-5 2.689E-4 2 10
31 19578372 Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice. Pubmed 1.069E-6 1.503E-5 1.001E-4 4.660E-4 2 13
32 25348719 Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development. Pubmed 3.164E-6 4.311E-5 2.869E-4 1.379E-3 2 22
33 9570752 Identification and functional characterization of a novel human protein highly related to the yeast dynamin-like GTPase Vps1p. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
34 21840923 Biochemical characterization of human dynamin-like protein 1. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
35 23028930 Defects in mitochondrial fission protein dynamin-related protein 1 are linked to apoptotic resistance and autophagy in a lung cancer model. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
36 26992161 Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
37 9348079 Identification and subcellular localization of a novel mammalian dynamin-related protein homologous to yeast Vps1p and Dnm1p. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
38 22511751 Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
39 28108329 Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
40 28383775 Polydatin impairs mitochondria fitness and ameliorates podocyte injury by suppressing Drp1 expression. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
41 21172823 An endophilin-dynamin complex promotes budding of clathrin-coated vesicles during synaptic vesicle recycling. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
42 30052866 In Vivo Deletion of β-Cell Drp1 Impairs Insulin Secretion Without Affecting Islet Oxygen Consumption. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
43 24947026 Exercise training decreases activation of the mitochondrial fission protein dynamin-related protein-1 in insulin-resistant human skeletal muscle. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
44 22789569 A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
45 28132464 [Mechanism of mitochondrial fission - structure and function of Drp1 protein]. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
46 26093086 Dynamin-related protein Drp1 is required for Bax translocation to mitochondria in response to irradiation-induced apoptosis. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
47 24899388 Involvement of Drp1 in hypoxia-induced migration of human glioblastoma U251 cells. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
48 25332205 Endogenous Drp1 mediates mitochondrial autophagy and protects the heart against energy stress. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
49 29158231 Receptor-mediated Drp1 oligomerization on endoplasmic reticulum. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
50 27556501 RALB provides critical survival signals downstream of Ras in acute myeloid leukemia. Pubmed 1.309E-4 2.897E-4 1.929E-3
5.708E-2
 1 1
Show 45 more annotations

9: Interaction [Display Chart] 5 input genes in category / 263 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:MIEF1 MIEF1 interactions 2.378E-9 6.254E-7 3.847E-6 6.254E-7 3 12
2 int:FIS1 FIS1 interactions 4.381E-8 5.762E-6 3.544E-5 1.152E-5 3 30
3 int:DNM1L DNM1L interactions 8.485E-8 7.439E-6 4.576E-5 2.232E-5 4 204
4 int:PEX11G PEX11G interactions 6.380E-7 4.195E-5 2.580E-4 1.678E-4 2 5
5 int:PEX11A PEX11A interactions 9.569E-7 5.033E-5 3.096E-4 2.517E-4 2 6
6 int:MFF MFF interactions 4.972E-6 2.179E-4 1.341E-3 1.308E-3 2 13
7 int:PEX11B PEX11B interactions 8.665E-6 3.256E-4 2.003E-3 2.279E-3 2 17
8 int:MARCH5 MARCH5 interactions 4.005E-5 1.317E-3 8.100E-3 1.053E-2 2 36
9 int:TBC1D15 TBC1D15 interactions 1.160E-4 3.390E-3 2.085E-2 3.051E-2 2 61
10 int:MAGEA1 MAGEA1 interactions 2.100E-4 5.524E-3 3.398E-2
5.524E-2
 2 82
11 int:CCDC126 CCDC126 interactions 1.129E-3 2.475E-2
1.523E-1
2.970E-1
 1 4
12 int:RGL3 RGL3 interactions 1.129E-3 2.475E-2
1.523E-1
2.970E-1
 1 4
13 int:SPATA19 SPATA19 interactions 1.694E-3 2.867E-2
1.763E-1
4.454E-1
 1 6
14 int:EI24 EI24 interactions 1.694E-3 2.867E-2
1.763E-1
4.454E-1
 1 6
15 int:RGL4 RGL4 interactions 1.976E-3 2.867E-2
1.763E-1
5.196E-1
 1 7
16 int:MIEF2 MIEF2 interactions 1.976E-3 2.867E-2
1.763E-1
5.196E-1
 1 7
17 int:MAGEA3 MAGEA3 interactions 1.976E-3 2.867E-2
1.763E-1
5.196E-1
 1 7
18 int:MAOA MAOA interactions 1.976E-3 2.867E-2
1.763E-1
5.196E-1
 1 7
19 int:LRRK2 LRRK2 interactions 2.071E-3 2.867E-2
1.763E-1
5.447E-1
 2 259
20 int:SCG3 SCG3 interactions 2.258E-3 2.969E-2
1.826E-1
5.938E-1
 1 8
21 int:CALM1 CALM1 interactions 3.622E-3 4.536E-2
2.790E-1
9.525E-1
 2 344
22 int:GDAP1 GDAP1 interactions 3.948E-3 4.720E-2
2.903E-1
1.000E0
 1 14
23 int:GABRR1 GABRR1 interactions 4.511E-3 4.944E-2
3.041E-1
1.000E0
 1 16
24 int:MAB21L2 MAB21L2 interactions 4.511E-3 4.944E-2
3.041E-1
1.000E0
 1 16
Show 19 more annotations

10: Cytoband [Display Chart] 5 input genes in category / 5 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 2q14.2 2q14.2 2.882E-3 4.682E-3 1.069E-2 1.441E-2 1 20
2 12p11.21 12p11.21 3.170E-3 4.682E-3 1.069E-2 1.585E-2 1 22
3 2q36.3 2q36.3 3.314E-3 4.682E-3 1.069E-2 1.657E-2 1 23
4 22q13 22q13 3.745E-3 4.682E-3 1.069E-2 1.873E-2 1 26
5 7q22.1 7q22.1 1.662E-2 1.662E-2 3.796E-2
8.311E-2
 1 116

11: Transcription Factor Binding Site [Display Chart] 2 input genes in category / 5 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 2 input genes in category / 2 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 389 RAS type GTPase family genenames.org 3.405E-3 6.810E-3 1.021E-2 6.810E-3 1 31
2 769 Anaphase promoting complex |Tetratricopeptide repeat domain containing genenames.org 1.260E-2 1.260E-2 1.890E-2 2.520E-2 1 115

13: Coexpression [Display Chart] 5 input genes in category / 407 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M16169 Genes able to induce cell death in an expression cDNA library screen. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.420E-4 2.975E-2
1.959E-1
5.778E-2
 2 88
2 20215539-SuppTable2a Human Lymphoma Dickens10 97genes GeneSigDB 1.586E-4 2.975E-2
1.959E-1
6.454E-2
 2 93
3 M3833 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with Pam3Csk4 (TLR1/2 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.975E-2
1.959E-1
2.945E-1
 2 199
4 M7683 Genes down-regulated in ankle joints: SPHK1 [GeneID=8877] versus wildtype over-expressing TNF [GeneID=7124]. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.975E-2
1.959E-1
2.945E-1
 2 199
5 M9994 Genes up-regulated during primary acute viral infection: B lymphocytes versus CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 7.236E-4 2.975E-2
1.959E-1
2.945E-1
 2 199
6 M3942 Genes down-regulated in comparison of dendritic cells (DC) stimulated with poly(I:C) (TLR3 agonist) at 4 h versus DC cells stimulated with CpG DNA (TLR9 agonist) at 4 h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.975E-2
1.959E-1
2.975E-1
 2 200
7 M9848 Genes down-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high versus CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell wildtype. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.975E-2
1.959E-1
2.975E-1
 2 200
8 M7711 Genes down-regulated in bone marrow-derived dendritic cellstreated by poly(IC): 0h versus 3h. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.975E-2
1.959E-1
2.975E-1
 2 200
9 M6094 Genes up-regulated in CD4 [GeneID=920] T cells activated by anti-CD3 and anti-CD28: IL4 [GeneID=3565] (2h) versus untreated (2h). MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.975E-2
1.959E-1
2.975E-1
 2 200
10 M4454 Genes down-regulated in comparison of memory IgM B cells versus blood plasma cells. MSigDB C7: Immunologic Signatures (v6.0) 7.309E-4 2.975E-2
1.959E-1
2.975E-1
 2 200
11 M18491 Genes up-regulated by ESRRA [GeneID=2101] only. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.713E-3 4.898E-2
3.227E-1
1.000E0
 2 388
12 M19927 Genes down-regulated in HCT116 cells (colon cancer) upon expression of MIR34B or MIR34C [GeneID=407041;407042] microRNAs. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.790E-3 4.898E-2
3.227E-1
1.000E0
 2 460
13 16818663-Table2 Human Esophagus Joshi06 20genes GeneSigDB 4.100E-3 4.898E-2
3.227E-1
1.000E0
 1 19
14 15656903-Table1 Human Lymphoma Melendez05 30genes GeneSigDB 4.961E-3 4.898E-2
3.227E-1
1.000E0
 1 23
15 M10456 Genes up-regulated in both the patients in the multicentric hepatocellular carcinoma (HCC) group and those with multicentric recurrence. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.391E-3 4.898E-2
3.227E-1
1.000E0
 1 25
16 M9729 Genes negatively correlated with the asbestos exposure of lung cancer patients. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.037E-3 4.898E-2
3.227E-1
1.000E0
 1 28
17 M1187 Genes down-regulated in MCF7 cells (breast cancer, normal TP53 [GeneID=7157]) undergoing mitotic arrest and apoptosis after treatment with 100 nM docetaxel [PubChem=148124]. MSigDB C2: CGP Curated Gene Sets (v6.0) 8.186E-3 4.898E-2
3.227E-1
1.000E0
 1 38
18 M15147 Up-regulated genes in hepatocellular carcinoma (HCC) subclass G12, defined by unsupervised clustering MSigDB C2: CGP Curated Gene Sets (v6.0) 8.400E-3 4.898E-2
3.227E-1
1.000E0
 1 39
19 19286929-SuppTable2m Mouse Lung Rangasamy09 43genes GeneSigDB 8.400E-3 4.898E-2
3.227E-1
1.000E0
 1 39
20 M17507 Transcripts significantly enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to both chemotactic (lysophosphatidic acid, LPA [PubChem=3988]) and haptotactic (fibronectin, FN1 [GeneID=2335) migratory stimuli. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.898E-2
3.227E-1
1.000E0
 1 43
21 M9642 Proteins that permeabilize mitochondria. MSigDB C2: CGP Curated Gene Sets (v6.0) 9.259E-3 4.898E-2
3.227E-1
1.000E0
 1 43
22 17720243-Table1B Human Lymphoma Bohling08 45genes GeneSigDB 9.473E-3 4.898E-2
3.227E-1
1.000E0
 1 44
23 16707422-tableS1b Human Prostate Hendriksen06 60genes GeneSigDB 9.688E-3 4.898E-2
3.227E-1
1.000E0
 1 45
24 20215539-SuppTable2b Human Lymphoma Dickens10 50genes GeneSigDB 1.033E-2 4.898E-2
3.227E-1
1.000E0
 1 48
25 15318932-Table3 Human Breast Abba04 52genes DCIS v IDC GeneSigDB 1.076E-2 4.898E-2
3.227E-1
1.000E0
 1 50
26 M2868 Genes down-regulated in epithelial lung cancer cell lines upon over-expression of an oncogenic form of KRAS [Gene ID=3845] gene and knockdown of TBK1 [Gene ID=29110] gene by RNAi. MSigDB C6: Oncogenic Signatures (v6.0) 1.076E-2 4.898E-2
3.227E-1
1.000E0
 1 50
27 11906190-Table2b-2 Human Colon Iizaka02 72genes GeneSigDB 1.076E-2 4.898E-2
3.227E-1
1.000E0
 1 50
28 M6225 Genes up-regulated in Barrett's esophagus compared to the normal tissue. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.097E-2 4.898E-2
3.227E-1
1.000E0
 1 51
29 M2742 Genes up-regulated in hepatocellular carcinoma (HCC) induced by overexpression of MYC [GeneID=4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.162E-2 4.898E-2
3.227E-1
1.000E0
 1 54
30 12460921-Table1 Human Intestine Hasegawa02 61genes GeneSigDB 1.204E-2 4.898E-2
3.227E-1
1.000E0
 1 56
31 11906190-Table2a-2 Human Colon Iizaka02 68genes GeneSigDB 1.247E-2 4.898E-2
3.227E-1
1.000E0
 1 58
32 16548883-Table1 Human StemCell Leong06 58genes GeneSigDB 1.247E-2 4.898E-2
3.227E-1
1.000E0
 1 58
33 12925741-Figure3 Human Lymphoma Jenner03 75genes GeneSigDB 1.290E-2 4.898E-2
3.227E-1
1.000E0
 1 60
34 M3432 Genes up-regulated in hepatocellular carcinoma (HCC) tissue of MYC and TGFA [GeneID=4609;7039] double transgenic mice. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.311E-2 4.898E-2
3.227E-1
1.000E0
 1 61
35 M9544 Top down-regulated genes from principal component 3 (PCA3) which captures variation among different plasma cell tumors arising from overexpression of BCL2L1 and MYC [GeneID=598;4609]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.482E-2 4.898E-2
3.227E-1
1.000E0
 1 69
36 M5190 Genes up-regulated in at least 8 of 11 sarcoma cell lines by trabectedin [PubChem=3199]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.525E-2 4.898E-2
3.227E-1
1.000E0
 1 71
37 M346 Candidate genes in significant regions of chromosomal copy number gains in a panel of melanoma samples. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.568E-2 4.898E-2
3.227E-1
1.000E0
 1 73
38 16449976-SuppTable1 Human Esophagus Wang06 82genes GeneSigDB 1.568E-2 4.898E-2
3.227E-1
1.000E0
 1 73
39 19861896-Table2 Human Brain Castells09 83genes GeneSigDB 1.589E-2 4.898E-2
3.227E-1
1.000E0
 1 74
40 M15130 Transcripts enriched in pseudopodia of NIH/3T3 cells (fibroblast) in response to the chemotactic migration stimulus by lysophosphatidic acid (LPA) [PubChem=3988]. MSigDB C2: CGP Curated Gene Sets (v6.0) 1.589E-2 4.898E-2
3.227E-1
1.000E0
 1 74
41 18381418-Table1 Mouse Prostate Ouyang08 121genes GeneSigDB 1.824E-2 4.898E-2
3.227E-1
1.000E0
 1 85
42 15705876-TableS3 Human Leukemia Passioura05 88genes GeneSigDB 1.824E-2 4.898E-2
3.227E-1
1.000E0
 1 85
43 18590516-TableS1 Human Viral Ciccaglione08 102genes GeneSigDB 1.866E-2 4.898E-2
3.227E-1
1.000E0
 1 87
44 19965622-TableS1a Human LymphaticEndothelialCells Norrmen09 107genes GeneSigDB 1.973E-2 4.898E-2
3.227E-1
1.000E0
 1 92
45 15297395-Table3 Human Lymphoma Sriuranpong04 109genes GeneSigDB 1.994E-2 4.898E-2
3.227E-1
1.000E0
 1 93
46 M5910 Genes involved in protein secretion pathway. MSigDB H: Hallmark Gene Sets (v6.0) 2.058E-2 4.898E-2
3.227E-1
1.000E0
 1 96
47 M1731 Cluster T7 of genes with similar expression profiles in thymic T lymphocytes after FOXP3 [GeneID=50943] loss of function (LOF). MSigDB C2: CGP Curated Gene Sets (v6.0) 2.100E-2 4.898E-2
3.227E-1
1.000E0
 1 98
48 12077300-SuppTable2 Human Lymphoma Lossos02 152genes GeneSigDB 2.121E-2 4.898E-2
3.227E-1
1.000E0
 1 99
49 M5949 Genes encoding components of peroxisome. MSigDB H: Hallmark Gene Sets (v6.0) 2.228E-2 4.898E-2
3.227E-1
1.000E0
 1 104
50 M5923 Genes up-regulated by activation of the PI3K/AKT/mTOR pathway. MSigDB H: Hallmark Gene Sets (v6.0) 2.249E-2 4.898E-2
3.227E-1
1.000E0
 1 105
Show 45 more annotations

14: Coexpression Atlas [Display Chart] 5 input genes in category / 262 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 2 input genes in category / 13 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M6968 GCM SMARCC1 Neighborhood of SMARCC1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.359E-3 2.644E-2
8.410E-2
9.567E-2
 1 37
2 M18347 GCM AIP Neighborhood of AIP MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.955E-3 2.644E-2
8.410E-2
1.034E-1
 1 40
3 M13925 MODULE 86 Small monomeric GTPases. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.550E-3 2.644E-2
8.410E-2
1.112E-1
 1 43
4 M5631 MODULE 87 Genes in the cancer module 87. MSigDb: C4 - CM: Cancer Modules (v6.0) 8.749E-3 2.644E-2
8.410E-2
1.137E-1
 1 44
5 M12006 GCM PRKCG Neighborhood of PRKCG MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.232E-2 2.644E-2
8.410E-2
1.601E-1
 1 62
6 M16495 GCM BECN1 Neighborhood of BECN1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.350E-2 2.644E-2
8.410E-2
1.756E-1
 1 68
7 M18480 MODULE 159 Translation regulation. MSigDb: C4 - CM: Cancer Modules (v6.0) 1.608E-2 2.644E-2
8.410E-2
2.090E-1
 1 81
8 M9981 MORF PPP2R5E Neighborhood of PPP2R5E MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.627E-2 2.644E-2
8.410E-2
2.116E-1
 1 82
9 M12365 GCM RING1 Neighborhood of RING1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.180E-2 3.149E-2
1.001E-1
2.834E-1
 1 110
10 M2127 GCM FANCC Neighborhood of FANCC MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.456E-2 3.192E-2
1.015E-1
3.192E-1
 1 124
11 M6400 MORF TPR Neighborhood of TPR MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.849E-2 3.367E-2
1.071E-1
3.704E-1
 1 144
Show 6 more annotations

16: MicroRNA [Display Chart] 5 input genes in category / 178 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 hsa-miR-1973:mirSVR lowEffct hsa-miR-1973:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 1.281E-4 2.280E-2
1.314E-1
 2.280E-2 2 260
2 hsa-miR-27a*:mirSVR highEffct hsa-miR-27a*:mirSVR nonconserved highEffect-0.5 MicroRNA.org 3.509E-4 2.537E-2
1.462E-1
6.247E-2
 2 431
3 hsa-miR-1224-3p:mirSVR highEffct hsa-miR-1224-3p:mirSVR nonconserved highEffect-0.5 MicroRNA.org 4.276E-4 2.537E-2
1.462E-1
7.611E-2
 2 476
4 hsa-miR-3150a-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-3 2.950E-2
1.700E-1
3.324E-1
 1 27
5 hsa-miR-3150b-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.867E-3 2.950E-2
1.700E-1
3.324E-1
 1 27
6 hsa-miR-937:mirSVR highEffct hsa-miR-937:mirSVR nonconserved highEffect-0.5 MicroRNA.org 2.144E-3 2.950E-2
1.700E-1
3.816E-1
 1 31
7 hsa-miR-4764-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 2.558E-3 2.950E-2
1.700E-1
4.554E-1
 1 37
8 hsa-miR-563:PITA hsa-miR-563:PITA TOP PITA 3.111E-3 2.950E-2
1.700E-1
5.537E-1
 1 45
9 hsa-miR-618:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.111E-3 2.950E-2
1.700E-1
5.537E-1
 1 45
10 hsa-miR-549a:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 3.456E-3 2.950E-2
1.700E-1
6.152E-1
 1 50
11 hsa-miR-616-3p:Functional MTI Functional MTI miRTarbase 3.663E-3 2.950E-2
1.700E-1
6.520E-1
 1 53
12 hsa-miR-629-5p:Functional MTI Functional MTI miRTarbase 4.284E-3 2.950E-2
1.700E-1
7.625E-1
 1 62
13 hsa-miR-3134:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.353E-3 2.950E-2
1.700E-1
7.748E-1
 1 63
14 hsa-miR-1208:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 4.560E-3 2.950E-2
1.700E-1
8.116E-1
 1 66
15 hsa-miR-1279:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.249E-3 2.950E-2
1.700E-1
9.344E-1
 1 76
16 hsa-miR-611:mirSVR highEffct hsa-miR-611:mirSVR nonconserved highEffect-0.5 MicroRNA.org 5.456E-3 2.950E-2
1.700E-1
9.712E-1
 1 79
17 hsa-miR-6760-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 5.525E-3 2.950E-2
1.700E-1
9.834E-1
 1 80
18 hsa-miR-593-5p:Functional MTI Functional MTI miRTarbase 5.525E-3 2.950E-2
1.700E-1
9.834E-1
 1 80
19 hsa-miR-22-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.007E-3 2.950E-2
1.700E-1
1.000E0
 1 87
20 hsa-miR-1538:mirSVR highEffct hsa-miR-1538:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.007E-3 2.950E-2
1.700E-1
1.000E0
 1 87
21 hsa-miR-1281:mirSVR highEffct hsa-miR-1281:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.352E-3 2.950E-2
1.700E-1
1.000E0
 1 92
22 hsa-miR-8081:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.489E-3 2.950E-2
1.700E-1
1.000E0
 1 94
23 hsa-miR-548av-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.627E-3 2.950E-2
1.700E-1
1.000E0
 1 96
24 hsa-miR-3131:mirSVR highEffct hsa-miR-3131:mirSVR nonconserved highEffect-0.5 MicroRNA.org 6.902E-3 2.950E-2
1.700E-1
1.000E0
 1 100
25 hsa-miR-3617-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 6.971E-3 2.950E-2
1.700E-1
1.000E0
 1 101
26 hsa-miR-509-3p:PITA hsa-miR-509-3p:PITA TOP PITA 7.109E-3 2.950E-2
1.700E-1
1.000E0
 1 103
27 hsa-miR-641:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.109E-3 2.950E-2
1.700E-1
1.000E0
 1 103
28 TGCAAAC,MIR-452:MSigDB TGCAAAC,MIR-452:MSigDB MSigDB 7.246E-3 2.950E-2
1.700E-1
1.000E0
 1 105
29 hsa-miR-139-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.246E-3 2.950E-2
1.700E-1
1.000E0
 1 105
30 hsa-miR-6758-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.453E-3 2.950E-2
1.700E-1
1.000E0
 1 108
31 hsa-miR-504-5p:Functional MTI Functional MTI miRTarbase 7.453E-3 2.950E-2
1.700E-1
1.000E0
 1 108
32 hsa-miR-564:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.659E-3 2.950E-2
1.700E-1
1.000E0
 1 111
33 hsa-miR-720:mirSVR highEffct hsa-miR-720:mirSVR nonconserved highEffect-0.5 MicroRNA.org 7.659E-3 2.950E-2
1.700E-1
1.000E0
 1 111
34 hsa-miR-4738-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 7.728E-3 2.950E-2
1.700E-1
1.000E0
 1 112
35 hsa-miR-5589-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.141E-3 2.950E-2
1.700E-1
1.000E0
 1 118
36 hsa-miR-548o-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.141E-3 2.950E-2
1.700E-1
1.000E0
 1 118
37 hsa-miR-1323:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.278E-3 2.950E-2
1.700E-1
1.000E0
 1 120
38 hsa-miR-1298-5p:TargetScan hsa-miR-1298-5p TargetScan 8.416E-3 2.950E-2
1.700E-1
1.000E0
 1 122
39 hsa-miR-2277:mirSVR highEffct hsa-miR-2277:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.622E-3 2.950E-2
1.700E-1
1.000E0
 1 125
40 hsa-miR-95:mirSVR highEffct hsa-miR-95:mirSVR nonconserved highEffect-0.5 MicroRNA.org 8.828E-3 2.950E-2
1.700E-1
1.000E0
 1 128
41 hsa-miR-552-5p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 8.966E-3 2.950E-2
1.700E-1
1.000E0
 1 130
42 hsa-miR-3195:mirSVR lowEffct hsa-miR-3195:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.172E-3 2.950E-2
1.700E-1
1.000E0
 1 133
43 hsa-miR-5192:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.240E-3 2.950E-2
1.700E-1
1.000E0
 1 134
44 hsa-miR-412:PITA hsa-miR-412:PITA TOP PITA 9.721E-3 2.950E-2
1.700E-1
1.000E0
 1 141
45 hsa-miR-8064:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 9.721E-3 2.950E-2
1.700E-1
1.000E0
 1 141
46 hsa-miR-1469:mirSVR lowEffct hsa-miR-1469:mirSVR nonconserved lowEffect-0.1-0.5 MicroRNA.org 9.927E-3 2.950E-2
1.700E-1
1.000E0
 1 144
47 hsa-miR-4532:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.006E-2 2.950E-2
1.700E-1
1.000E0
 1 146
48 hsa-miR-382-5p:TargetScan hsa-miR-382-5p TargetScan 1.020E-2 2.950E-2
1.700E-1
1.000E0
 1 148
49 hsa-miR-200a-3p:Functional MTI Functional MTI miRTarbase 1.034E-2 2.950E-2
1.700E-1
1.000E0
 1 150
50 hsa-miR-196b-5p:Functional MTI Functional MTI miRTarbase 1.034E-2 2.950E-2
1.700E-1
1.000E0
 1 150
Show 45 more annotations

17: Drug [Display Chart] 5 input genes in category / 395 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 ctd:D005459 Fluorides CTD 2.074E-4 3.842E-2
2.519E-1
8.194E-2
 2 105
2 CID000310557 2-(4-fluorobenzoylamino)-benzoic acid methyl ester Stitch 2.189E-4 3.842E-2
2.519E-1
8.647E-2
 1 1
3 CID000003280 ethaverine Stitch 6.566E-4 3.842E-2
2.519E-1
2.594E-1
 1 3
4 3028 DN Moxalactam disodium salt [64953-12-4]; Down 200; 7uM; HL60; HT HG-U133A Broad Institute CMAP Down 6.985E-4 3.842E-2
2.519E-1
2.759E-1
 2 193
5 1917 DN Lidocaone hydrochloride [73-78-9]; Down 200; 14.8uM; PC3; HG-U133A Broad Institute CMAP Down 7.203E-4 3.842E-2
2.519E-1
2.845E-1
 2 196
6 2544 DN Medrysone [2668-66-8]; Down 200; 11.6uM; HL60; HT HG-U133A Broad Institute CMAP Down 7.276E-4 3.842E-2
2.519E-1
2.874E-1
 2 197
7 1670 UP Azaguanine-8 [134-58-7]; Up 200; 26.2uM; MCF7; HT HG-U133A Broad Institute CMAP Up 7.349E-4 3.842E-2
2.519E-1
2.903E-1
 2 198
8 ctd:C009618 O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate CTD 8.339E-4 3.842E-2
2.519E-1
3.294E-1
 2 211
9 CID006834124 AC1OAR8J Stitch 8.754E-4 3.842E-2
2.519E-1
3.458E-1
 1 4
10 ctd:C549041 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone CTD 1.094E-3 3.929E-2
2.576E-1
4.322E-1
 1 5
11 CID000162755 N-beta-alanyldopamine Stitch 1.094E-3 3.929E-2
2.576E-1
4.322E-1
 1 5
12 ctd:C033772 N-(4-aminobutyl)-5-chloro-2-naphthalenesulfonamide CTD 1.313E-3 3.989E-2
2.616E-1
5.186E-1
 1 6
13 CID000038884 bupirimate Stitch 1.313E-3 3.989E-2
2.616E-1
5.186E-1
 1 6
14 CID005396227 Dynasore hydrate Stitch 1.532E-3 4.093E-2
2.684E-1
6.050E-1
 1 7
15 CID000031252 2,5-dimethylpyrazine Stitch 1.750E-3 4.093E-2
2.684E-1
6.913E-1
 1 8
16 ctd:D001386 Azides CTD 1.969E-3 4.093E-2
2.684E-1
7.777E-1
 1 9
17 ctd:C467051 trifloxystrobin CTD 1.969E-3 4.093E-2
2.684E-1
7.777E-1
 1 9
18 CID000004342 N-acetylprocainamide Stitch 1.969E-3 4.093E-2
2.684E-1
7.777E-1
 1 9
19 CID005360531 Reactive Black 5 Stitch 1.969E-3 4.093E-2
2.684E-1
7.777E-1
 1 9
20 CID005289288 tetramethylrhodamine-5-maleimide Stitch 2.187E-3 4.320E-2
2.833E-1
8.640E-1
 1 10
21 CID005327863 Go7874 Stitch 2.624E-3 4.801E-2
3.148E-1
1.000E0
 1 12
22 CID000068054 AC1L28XQ Stitch 3.061E-3 4.801E-2
3.148E-1
1.000E0
 1 14
23 CID000015139 fluanisone Stitch 3.498E-3 4.801E-2
3.148E-1
1.000E0
 1 16
24 CID005270634 library 2 Stitch 4.153E-3 4.801E-2
3.148E-1
1.000E0
 1 19
25 CID000079803 1-pyrroline Stitch 4.153E-3 4.801E-2
3.148E-1
1.000E0
 1 19
26 ctd:C562254 2'-(4-chlorophenyl)-3-(4-chlorophenylidene)-5,10-dimethyl-12-methylene-decahydro-1,2-(1',3'-dioxocyclopenta(c))azuleno(4,5-b)furan-4,11-dione CTD 4.153E-3 4.801E-2
3.148E-1
1.000E0
 1 19
27 CID004635864 I om Stitch 4.153E-3 4.801E-2
3.148E-1
1.000E0
 1 19
28 CID000153974 etoxazole Stitch 4.371E-3 4.801E-2
3.148E-1
1.000E0
 1 20
29 ctd:C016766 sulforafan CTD 4.524E-3 4.801E-2
3.148E-1
1.000E0
 2 497
30 CID000449547 F-F-F Stitch 4.589E-3 4.801E-2
3.148E-1
1.000E0
 1 21
31 CID011840961 N-[4,5,7-Tricarboxyheptanoyl]-L-Gamma-Glutamyl-N-{2-[4-({5-[(Formylamino)methyl]-3-Furyl}methoxy)phenyl]ethyl}-D-Glutamine Stitch 4.807E-3 4.801E-2
3.148E-1
1.000E0
 1 22
32 CID000003052 diethylcarbamazine Stitch 4.807E-3 4.801E-2
3.148E-1
1.000E0
 1 22
33 ctd:C555916 MitoTEMPO CTD 4.807E-3 4.801E-2
3.148E-1
1.000E0
 1 22
34 ctd:C063261 acetylleucyl-leucyl-norleucinal CTD 5.243E-3 4.801E-2
3.148E-1
1.000E0
 1 24
35 CID000103764 DiOC6(3 Stitch 5.897E-3 4.801E-2
3.148E-1
1.000E0
 1 27
36 CID000006054 2-phenylethanol Stitch 6.550E-3 4.801E-2
3.148E-1
1.000E0
 1 30
37 CID000010428 mevalonolactone Stitch 6.550E-3 4.801E-2
3.148E-1
1.000E0
 1 30
38 CID000007118 veratryl alcohol Stitch 6.768E-3 4.801E-2
3.148E-1
1.000E0
 1 31
39 CID000063022 maya Stitch 6.768E-3 4.801E-2
3.148E-1
1.000E0
 1 31
40 CID005287777 BG-G Stitch 7.204E-3 4.801E-2
3.148E-1
1.000E0
 1 33
41 CID000446658 AC1L9JXQ Stitch 7.204E-3 4.801E-2
3.148E-1
1.000E0
 1 33
42 CID000021218 Aliquat 336 Stitch 7.421E-3 4.801E-2
3.148E-1
1.000E0
 1 34
43 CID005091655 EMCs Stitch 7.421E-3 4.801E-2
3.148E-1
1.000E0
 1 34
44 ctd:C503753 Indolinone A CTD 7.639E-3 4.801E-2
3.148E-1
1.000E0
 1 35
45 CID000000674 dimethylamine Stitch 7.856E-3 4.801E-2
3.148E-1
1.000E0
 1 36
46 ctd:C013531 ferric ammonium citrate CTD 8.509E-3 4.801E-2
3.148E-1
1.000E0
 1 39
47 CID000005433 racephenicol Stitch 8.726E-3 4.801E-2
3.148E-1
1.000E0
 1 40
48 CID009960660 Z-Ile-Glu(O-t-butyl)-Ala-Leucinal Stitch 8.944E-3 4.801E-2
3.148E-1
1.000E0
 1 41
49 CID005359521 lissamine Stitch 9.596E-3 4.801E-2
3.148E-1
1.000E0
 1 44
50 CID006397184 $l^{1}-borane Stitch 9.596E-3 4.801E-2
3.148E-1
1.000E0
 1 44
Show 45 more annotations

18: Disease [Display Chart] 4 input genes in category / 49 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 cv:C3280660 Encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission Clinical Variations 2.468E-4 6.048E-3 2.709E-2 1.210E-2 1 1
2 C3280660 ENCEPHALOPATHY, LETHAL, DUE TO DEFECTIVE MITOCHONDRIAL AND PEROXISOMAL FISSION DisGeNET Curated 2.468E-4 6.048E-3 2.709E-2 1.210E-2 1 1
3 C0349566 Squamous cell carcinoma of tongue DisGeNET BeFree 4.715E-4 7.701E-3 3.450E-2 2.310E-2 2 145
4 C0085584 Encephalopathies DisGeNET Curated 8.164E-4 1.000E-2 4.479E-2 4.000E-2 2 191
5 C0271385 Horizontal Nystagmus DisGeNET Curated 2.466E-3 2.417E-2
1.082E-1
1.208E-1
 1 10
6 C2931673 Ceroid lipofuscinosis, neuronal 1, infantile DisGeNET Curated 2.959E-3 2.417E-2
1.082E-1
1.450E-1
 1 12
7 C0004782 Basal Ganglia Diseases DisGeNET Curated 4.436E-3 3.105E-2
1.391E-1
2.174E-1
 1 18
8 C0338508 Optic Atrophy, Autosomal Dominant DisGeNET Curated 6.894E-3 3.616E-2
1.620E-1
3.378E-1
 1 28
9 C2699510 Split-Hand/Foot Malformation DisGeNET BeFree 8.122E-3 3.616E-2
1.620E-1
3.980E-1
 1 33
10 C3489791 Parkinson Disease, Familial, Type 1 DisGeNET BeFree 8.122E-3 3.616E-2
1.620E-1
3.980E-1
 1 33
11 C1844505 Pointed chin DisGeNET Curated 8.122E-3 3.616E-2
1.620E-1
3.980E-1
 1 33
12 C0029132 Disorder of the optic nerve DisGeNET Curated 8.857E-3 3.616E-2
1.620E-1
4.340E-1
 1 36
13 C0162666 Mitochondrial Encephalomyopathies DisGeNET Curated 9.593E-3 3.616E-2
1.620E-1
4.700E-1
 1 39
14 C0751955 Brain Infarction DisGeNET Curated 1.057E-2 3.700E-2
1.658E-1
5.181E-1
 1 43
15 C0235659 Reduced fetal movement DisGeNET Curated 1.351E-2 4.413E-2
1.977E-1
6.619E-1
 1 55
16 C0423224 Sunken eyes DisGeNET Curated 1.546E-2 4.457E-2
1.996E-1
7.576E-1
 1 63
17 C0014306 Enophthalmos DisGeNET Curated 1.546E-2 4.457E-2
1.996E-1
7.576E-1
 1 63
18 C1858430 Death in infancy DisGeNET Curated 2.009E-2 4.849E-2
2.172E-1
9.844E-1
 1 82
19 C1844947 Death in early childhood DisGeNET Curated 2.009E-2 4.849E-2
2.172E-1
9.844E-1
 1 82
20 C1175175 Severe Acute Respiratory Syndrome DisGeNET Curated 2.033E-2 4.849E-2
2.172E-1
9.963E-1
 1 83
21 C0278124 Absent tendon reflex DisGeNET Curated 2.276E-2 4.849E-2
2.172E-1
1.000E0
 1 93
22 C0234146 Absent reflex DisGeNET Curated 2.276E-2 4.849E-2
2.172E-1
1.000E0
 1 93
23 C0241772 Reflex, Deep Tendon, Absent DisGeNET Curated 2.276E-2 4.849E-2
2.172E-1
1.000E0
 1 93
Show 18 more annotations