Toppgene analysis for Wikipedia protein communities, toppgene analysis, cc194_18, positive side

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1: GO: Molecular Function [Display Chart] 18 input genes in category / 134 annotations before applied cutoff / 18661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0009881 photoreceptor activity 3.404E-7 2.805E-5 1.537E-4 4.561E-5 3 15
2 GO:0004935 adrenergic receptor activity 4.187E-7 2.805E-5 1.537E-4 5.610E-5 3 16
3 GO:0031762 follicle-stimulating hormone receptor binding 8.788E-7 2.944E-5 1.613E-4 1.178E-4 2 2
4 GO:0031691 alpha-1A adrenergic receptor binding 8.788E-7 2.944E-5 1.613E-4 1.178E-4 2 2
5 GO:0031826 type 2A serotonin receptor binding 2.635E-6 5.044E-5 2.763E-4 3.531E-4 2 3
6 GO:0004937 alpha1-adrenergic receptor activity 2.635E-6 5.044E-5 2.763E-4 3.531E-4 2 3
7 GO:0031692 alpha-1B adrenergic receptor binding 2.635E-6 5.044E-5 2.763E-4 3.531E-4 2 3
8 GO:0004936 alpha-adrenergic receptor activity 1.315E-5 2.203E-4 1.207E-3 1.762E-3 2 6
9 GO:0008227 G protein-coupled amine receptor activity 1.524E-5 2.270E-4 1.244E-3 2.043E-3 3 51
10 GO:0031821 G protein-coupled serotonin receptor binding 1.840E-5 2.466E-4 1.351E-3 2.466E-3 2 7
11 GO:0008020 G protein-coupled photoreceptor activity 4.808E-5 5.858E-4 3.209E-3 6.443E-3 2 11
12 GO:0031701 angiotensin receptor binding 5.767E-5 6.440E-4 3.528E-3 7.728E-3 2 12
13 GO:0016918 retinal binding 7.942E-5 8.186E-4 4.485E-3 1.064E-2 2 14
14 GO:0001664 G protein-coupled receptor binding 1.217E-4 1.164E-3 6.380E-3 1.630E-2 4 276
15 GO:0031690 adrenergic receptor binding 1.653E-4 1.476E-3 8.088E-3 2.214E-2 2 20
16 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process 2.602E-4 2.179E-3 1.194E-2 3.487E-2 2 25
17 GO:0001965 G-protein alpha-subunit binding 4.558E-4 3.593E-3 1.969E-2
6.108E-2
 2 33
18 GO:0005501 retinoid binding 6.052E-4 4.505E-3 2.468E-2
8.110E-2
 2 38
19 GO:0019840 isoprenoid binding 7.047E-4 4.970E-3 2.723E-2
9.443E-2
 2 41
20 GO:0043028 cysteine-type endopeptidase regulator activity involved in apoptotic process 8.869E-4 5.170E-3 2.833E-2
1.189E-1
 2 46
21 GO:0031713 B2 bradykinin receptor binding 9.646E-4 5.170E-3 2.833E-2
1.293E-1
 1 1
22 GO:0031896 V2 vasopressin receptor binding 9.646E-4 5.170E-3 2.833E-2
1.293E-1
 1 1
23 GO:0005395 eye pigment precursor transporter activity 9.646E-4 5.170E-3 2.833E-2
1.293E-1
 1 1
24 GO:0031859 platelet activating factor receptor binding 9.646E-4 5.170E-3 2.833E-2
1.293E-1
 1 1
25 GO:0004941 beta2-adrenergic receptor activity 9.646E-4 5.170E-3 2.833E-2
1.293E-1
 1 1
26 GO:0004869 cysteine-type endopeptidase inhibitor activity 1.407E-3 7.251E-3 3.973E-2
1.885E-1
 2 58
27 GO:0005096 GTPase activator activity 2.379E-3 1.174E-2
6.432E-2
3.187E-1
 3 283
28 GO:0004946 bombesin receptor activity 2.891E-3 1.174E-2
6.432E-2
3.874E-1
 1 3
29 GO:0005502 11-cis retinal binding 2.891E-3 1.174E-2
6.432E-2
3.874E-1
 1 3
30 GO:0031711 bradykinin receptor binding 2.891E-3 1.174E-2
6.432E-2
3.874E-1
 1 3
31 GO:0004939 beta-adrenergic receptor activity 2.891E-3 1.174E-2
6.432E-2
3.874E-1
 1 3
32 GO:0070573 metallodipeptidase activity 2.891E-3 1.174E-2
6.432E-2
3.874E-1
 1 3
33 GO:0031893 vasopressin receptor binding 2.891E-3 1.174E-2
6.432E-2
3.874E-1
 1 3
34 GO:0030695 GTPase regulator activity 3.135E-3 1.236E-2
6.770E-2
4.201E-1
 3 312
35 GO:0019842 vitamin binding 3.347E-3 1.281E-2
7.021E-2
4.485E-1
 2 90
36 GO:0051380 norepinephrine binding 3.853E-3 1.434E-2
7.858E-2
5.163E-1
 1 4
37 GO:0060589 nucleoside-triphosphatase regulator activity 4.126E-3 1.494E-2
8.186E-2
5.528E-1
 3 344
38 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity 4.814E-3 1.698E-2
9.301E-2
6.451E-1
 1 5
39 GO:0005262 calcium channel activity 5.310E-3 1.824E-2
9.995E-2
7.115E-1
 2 114
40 GO:0051379 epinephrine binding 5.774E-3 1.934E-2
1.060E-1
7.738E-1
 1 6
41 GO:0015085 calcium ion transmembrane transporter activity 7.055E-3 2.306E-2
1.263E-1
9.453E-1
 2 132
42 GO:0034235 GPI anchor binding 7.692E-3 2.454E-2
1.345E-1
1.000E0
 1 8
43 GO:0035615 clathrin adaptor activity 8.650E-3 2.634E-2
1.443E-1
1.000E0
 1 9
44 GO:0098748 endocytic adaptor activity 8.650E-3 2.634E-2
1.443E-1
1.000E0
 1 9
45 GO:0031702 type 1 angiotensin receptor binding 9.606E-3 2.798E-2
1.533E-1
1.000E0
 1 10
46 GO:0035612 AP-2 adaptor complex binding 9.606E-3 2.798E-2
1.533E-1
1.000E0
 1 10
47 GO:0031748 D1 dopamine receptor binding 1.056E-2 3.011E-2
1.650E-1
1.000E0
 1 11
48 GO:0035240 dopamine binding 1.152E-2 3.109E-2
1.703E-1
1.000E0
 1 12
49 GO:0008179 adenylate cyclase binding 1.152E-2 3.109E-2
1.703E-1
1.000E0
 1 12
50 GO:0004866 endopeptidase inhibitor activity 1.160E-2 3.109E-2
1.703E-1
1.000E0
 2 171
Show 45 more annotations

2: GO: Biological Process [Display Chart] 18 input genes in category / 864 annotations before applied cutoff / 18623 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0007602 phototransduction 2.111E-11 1.824E-8 1.339E-7 1.824E-8 6 63
2 GO:0009581 detection of external stimulus 7.446E-11 2.453E-8 1.800E-7 6.433E-8 7 156
3 GO:0009582 detection of abiotic stimulus 8.517E-11 2.453E-8 1.800E-7 7.359E-8 7 159
4 GO:0009583 detection of light stimulus 1.160E-10 2.505E-8 1.839E-7 1.002E-7 6 83
5 GO:0071875 adrenergic receptor signaling pathway 1.233E-8 2.130E-6 1.563E-5 1.065E-5 4 28
6 GO:0009416 response to light stimulus 1.601E-8 2.306E-6 1.692E-5 1.383E-5 7 337
7 GO:0003321 positive regulation of blood pressure by epinephrine-norepinephrine 4.233E-8 5.225E-6 3.835E-5 3.657E-5 3 8
8 GO:0007603 phototransduction, visible light 4.919E-8 5.312E-6 3.899E-5 4.250E-5 4 39
9 GO:0001993 regulation of systemic arterial blood pressure by norepinephrine-epinephrine 6.346E-8 6.092E-6 4.471E-5 5.483E-5 3 9
10 GO:0045744 negative regulation of G protein-coupled receptor signaling pathway 1.062E-7 9.172E-6 6.732E-5 9.172E-5 4 47
11 GO:0008277 regulation of G protein-coupled receptor signaling pathway 1.588E-7 1.248E-5 9.157E-5 1.372E-4 5 137
12 GO:0009314 response to radiation 1.800E-7 1.296E-5 9.512E-5 1.555E-4 7 480
13 GO:0018298 protein-chromophore linkage 3.425E-7 2.276E-5 1.671E-4 2.959E-4 3 15
14 GO:0009584 detection of visible light 4.241E-7 2.617E-5 1.921E-4 3.664E-4 4 66
15 GO:0006940 regulation of smooth muscle contraction 5.077E-7 2.925E-5 2.146E-4 4.387E-4 4 69
16 GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway 9.701E-7 5.069E-5 3.721E-4 8.382E-4 4 81
17 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway 9.974E-7 5.069E-5 3.721E-4 8.618E-4 3 21
18 GO:0002029 desensitization of G protein-coupled receptor signaling pathway 1.515E-6 6.890E-5 5.057E-4 1.309E-3 3 24
19 GO:0022401 negative adaptation of signaling pathway 1.515E-6 6.890E-5 5.057E-4 1.309E-3 3 24
20 GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway 1.764E-6 7.622E-5 5.594E-4 1.524E-3 4 94
21 GO:0023058 adaptation of signaling pathway 1.944E-6 7.998E-5 5.870E-4 1.680E-3 3 26
22 GO:0002032 desensitization of G protein-coupled receptor signaling pathway by arrestin 2.646E-6 1.039E-4 7.625E-4 2.286E-3 2 3
23 GO:0006939 smooth muscle contraction 3.814E-6 1.373E-4 1.008E-3 3.296E-3 4 114
24 GO:1903524 positive regulation of blood circulation 3.814E-6 1.373E-4 1.008E-3 3.296E-3 4 114
25 GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure 5.288E-6 1.757E-4 1.290E-3 4.569E-3 2 4
26 GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine 5.288E-6 1.757E-4 1.290E-3 4.569E-3 2 4
27 GO:0045823 positive regulation of heart contraction 7.899E-6 2.528E-4 1.855E-3 6.824E-3 3 41
28 GO:0003099 positive regulation of the force of heart contraction by chemical signal 8.808E-6 2.718E-4 1.995E-3 7.610E-3 2 5
29 GO:0045933 positive regulation of muscle contraction 1.276E-5 3.781E-4 2.775E-3 1.103E-2 3 48
30 GO:0001978 regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback 1.321E-5 3.781E-4 2.775E-3 1.141E-2 2 6
31 GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 1.357E-5 3.781E-4 2.775E-3 1.172E-2 4 157
32 GO:0045777 positive regulation of blood pressure 1.444E-5 3.900E-4 2.862E-3 1.248E-2 3 50
33 GO:0006937 regulation of muscle contraction 1.573E-5 4.118E-4 3.022E-3 1.359E-2 4 163
34 GO:0030168 platelet activation 1.772E-5 4.502E-4 3.304E-3 1.531E-2 4 168
35 GO:0042699 follicle-stimulating hormone signaling pathway 1.848E-5 4.561E-4 3.348E-3 1.596E-2 2 7
36 GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal 1.927E-5 4.623E-4 3.393E-3 1.665E-2 3 55
37 GO:0048511 rhythmic process 1.980E-5 4.623E-4 3.393E-3 1.711E-2 5 366
38 GO:0050880 regulation of blood vessel size 2.080E-5 4.712E-4 3.459E-3 1.797E-2 4 175
39 GO:0035150 regulation of tube size 2.127E-5 4.712E-4 3.459E-3 1.838E-2 4 176
40 GO:0003057 regulation of the force of heart contraction by chemical signal 2.462E-5 5.188E-4 3.808E-3 2.127E-2 2 8
41 GO:0003025 regulation of systemic arterial blood pressure by baroreceptor feedback 2.462E-5 5.188E-4 3.808E-3 2.127E-2 2 8
42 GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 2.533E-5 5.210E-4 3.824E-3 2.188E-2 4 184
43 GO:0003018 vascular process in circulatory system 3.650E-5 7.333E-4 5.382E-3 3.153E-2 4 202
44 GO:0007601 visual perception 4.656E-5 9.142E-4 6.710E-3 4.022E-2 4 215
45 GO:0050953 sensory perception of light stimulus 4.914E-5 9.396E-4 6.896E-3 4.246E-2 4 218
46 GO:0090257 regulation of muscle system process 5.002E-5 9.396E-4 6.896E-3 4.322E-2 4 219
47 GO:0008016 regulation of heart contraction 7.375E-5 1.356E-3 9.950E-3
6.372E-2
 4 242
48 GO:0002031 G protein-coupled receptor internalization 9.196E-5 1.655E-3 1.215E-2
7.945E-2
 2 15
49 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 1.024E-4 1.806E-3 1.325E-2
8.848E-2
 3 96
50 GO:2000117 negative regulation of cysteine-type endopeptidase activity 1.122E-4 1.939E-3 1.423E-2
9.695E-2
 3 99
Show 45 more annotations

3: GO: Cellular Component [Display Chart] 18 input genes in category / 58 annotations before applied cutoff / 19061 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GO:0001750 photoreceptor outer segment 6.197E-5 3.594E-3 1.670E-2 3.594E-3 3 83
2 GO:0097381 photoreceptor disc membrane 1.427E-4 4.137E-3 1.922E-2 8.275E-3 2 19
3 GO:0043197 dendritic spine 3.644E-4 5.377E-3 2.498E-2 2.114E-2 3 151
4 GO:0044309 neuron spine 3.788E-4 5.377E-3 2.498E-2 2.197E-2 3 153
5 GO:0009898 cytoplasmic side of plasma membrane 5.066E-4 5.377E-3 2.498E-2 2.938E-2 3 169
6 GO:0005834 heterotrimeric G-protein complex 5.803E-4 5.377E-3 2.498E-2 3.366E-2 2 38
7 GO:0098562 cytoplasmic side of membrane 6.490E-4 5.377E-3 2.498E-2 3.764E-2 3 184
8 GO:0060342 photoreceptor inner segment membrane 1.888E-3 1.227E-2
5.699E-2
1.095E-1
 1 2
9 GO:0005905 clathrin-coated pit 1.903E-3 1.227E-2
5.699E-2
1.104E-1
 2 69
10 GO:0060170 ciliary membrane 2.937E-3 1.704E-2
7.915E-2
1.704E-1
 2 86
11 GO:0031253 cell projection membrane 3.519E-3 1.761E-2
8.184E-2
2.041E-1
 3 332
12 GO:0005901 caveola 3.644E-3 1.761E-2
8.184E-2
2.114E-1
 2 96
13 GO:0044853 plasma membrane raft 4.342E-3 1.822E-2
8.468E-2
2.518E-1
 2 105
14 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane 4.504E-3 1.822E-2
8.468E-2
2.612E-1
 2 107
15 GO:0098536 deuterosome 4.713E-3 1.822E-2
8.468E-2
2.734E-1
 1 5
16 GO:0098794 postsynapse 8.142E-3 2.864E-2
1.331E-1
4.723E-1
 3 449
17 GO:0042383 sarcolemma 8.889E-3 2.864E-2
1.331E-1
5.156E-1
 2 152
18 GO:0019897 extrinsic component of plasma membrane 8.889E-3 2.864E-2
1.331E-1
5.156E-1
 2 152
19 GO:0031143 pseudopodium 1.594E-2 4.429E-2
2.058E-1
9.245E-1
 1 17
20 GO:0042622 photoreceptor outer segment membrane 1.687E-2 4.429E-2
2.058E-1
9.784E-1
 1 18
21 GO:0000242 pericentriolar material 1.687E-2 4.429E-2
2.058E-1
9.784E-1
 1 18
22 GO:0045211 postsynaptic membrane 1.874E-2 4.429E-2
2.058E-1
1.000E0
 2 225
23 GO:0031528 microvillus membrane 1.966E-2 4.429E-2
2.058E-1
1.000E0
 1 21
24 GO:0030867 rough endoplasmic reticulum membrane 1.966E-2 4.429E-2
2.058E-1
1.000E0
 1 21
25 GO:0014069 postsynaptic density 1.985E-2 4.429E-2
2.058E-1
1.000E0
 2 232
26 GO:0099572 postsynaptic specialization 1.985E-2 4.429E-2
2.058E-1
1.000E0
 2 232
27 GO:0016323 basolateral plasma membrane 2.182E-2 4.687E-2
2.178E-1
1.000E0
 2 244
28 GO:0060076 excitatory synapse 2.317E-2 4.800E-2
2.230E-1
1.000E0
 2 252
29 GO:0032809 neuronal cell body membrane 2.705E-2 4.887E-2
2.271E-1
1.000E0
 1 29
30 GO:0044298 cell body membrane 2.705E-2 4.887E-2
2.271E-1
1.000E0
 1 29
31 GO:0098852 lytic vacuole membrane 2.762E-2 4.887E-2
2.271E-1
1.000E0
 2 277
32 GO:0005765 lysosomal membrane 2.762E-2 4.887E-2
2.271E-1
1.000E0
 2 277
33 GO:0019898 extrinsic component of membrane 2.781E-2 4.887E-2
2.271E-1
1.000E0
 2 278
Show 28 more annotations

4: Human Phenotype [Display Chart] 6 input genes in category / 510 annotations before applied cutoff / 4707 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 HP:0001147 Retinal exudate 3.263E-6 1.478E-3 1.007E-2 1.664E-3 4 104
2 HP:0030506 Yellow/white lesions of the retina 5.796E-6 1.478E-3 1.007E-2 2.956E-3 4 120
3 HP:0000501 Glaucoma 1.779E-5 2.051E-3 1.397E-2 9.073E-3 5 376
4 HP:0001123 Visual field defect 5.801E-5 2.051E-3 1.397E-2 2.959E-2 4 214
5 HP:0007769 Peripheral retinal degeneration 6.924E-5 2.051E-3 1.397E-2 3.531E-2 3 73
6 HP:0007770 Hypoplasia of the retina 6.924E-5 2.051E-3 1.397E-2 3.531E-2 3 73
7 HP:0011530 Retinal hole 7.213E-5 2.051E-3 1.397E-2 3.679E-2 3 74
8 HP:0011532 Subretinal exudate 7.213E-5 2.051E-3 1.397E-2 3.679E-2 3 74
9 HP:0008020 Cone dystrophy 7.213E-5 2.051E-3 1.397E-2 3.679E-2 3 74
10 HP:0007675 Progressive night blindness 7.213E-5 2.051E-3 1.397E-2 3.679E-2 3 74
11 HP:0100012 Neoplasm of the eye 7.581E-5 2.051E-3 1.397E-2 3.866E-2 4 229
12 HP:0007893 Progressive retinal degeneration 7.815E-5 2.051E-3 1.397E-2 3.986E-2 3 76
13 HP:0030469 Abnormal dark-adapted electroretinogram 8.128E-5 2.051E-3 1.397E-2 4.145E-2 3 77
14 HP:0030470 Abnormal dark-adapted bright flash electroretinogram 8.128E-5 2.051E-3 1.397E-2 4.145E-2 3 77
15 HP:0007984 Electronegative electroretinogram 8.128E-5 2.051E-3 1.397E-2 4.145E-2 3 77
16 HP:0007898 Exudative retinopathy 8.128E-5 2.051E-3 1.397E-2 4.145E-2 3 77
17 HP:0030478 Abnormal amplitude of dark-adapted bright flash electroretinogram 8.128E-5 2.051E-3 1.397E-2 4.145E-2 3 77
18 HP:0007868 Age-related macular degeneration 8.128E-5 2.051E-3 1.397E-2 4.145E-2 3 77
19 HP:0012714 Severe hearing impairment 8.449E-5 2.051E-3 1.397E-2 4.309E-2 3 78
20 HP:0008625 Severe sensorineural hearing impairment 8.449E-5 2.051E-3 1.397E-2 4.309E-2 3 78
21 HP:0008181 Abetalipoproteinemia 9.116E-5 2.051E-3 1.397E-2 4.649E-2 3 80
22 HP:0000547 Tapetoretinal degeneration 9.462E-5 2.051E-3 1.397E-2 4.826E-2 3 81
23 HP:0000654 Decreased light- and dark-adapted electroretinogram amplitude 9.462E-5 2.051E-3 1.397E-2 4.826E-2 3 81
24 HP:0001070 Mottled pigmentation 9.817E-5 2.051E-3 1.397E-2
5.006E-2
 3 82
25 HP:0000618 Blindness 1.005E-4 2.051E-3 1.397E-2
5.127E-2
 4 246
26 HP:0000655 Vitreoretinal degeneration 1.055E-4 2.065E-3 1.407E-2
5.381E-2
 3 84
27 HP:0008323 Abnormal light- and dark-adapted electroretinogram 1.093E-4 2.065E-3 1.407E-2
5.576E-2
 3 85
28 HP:0000533 Chorioretinal atrophy 1.172E-4 2.067E-3 1.408E-2
5.978E-2
 3 87
29 HP:0200065 Chorioretinal degeneration 1.255E-4 2.067E-3 1.408E-2
6.398E-2
 3 89
30 HP:0001146 Pigmentary retinal degeneration 1.255E-4 2.067E-3 1.408E-2
6.398E-2
 3 89
31 HP:0008046 Abnormality of the retinal vasculature 1.269E-4 2.067E-3 1.408E-2
6.471E-2
 4 261
32 HP:0030466 Abnormal full-field electroretinogram 1.297E-4 2.067E-3 1.408E-2
6.616E-2
 3 90
33 HP:0003563 Decreased LDL cholesterol concentration 1.341E-4 2.072E-3 1.412E-2
6.838E-2
 3 91
34 HP:0007754 Macular dystrophy 1.431E-4 2.146E-3 1.462E-2
7.297E-2
 3 93
35 HP:0000550 Undetectable electroretinogram 1.830E-4 2.523E-3 1.719E-2
9.335E-2
 3 101
36 HP:0011505 Cystoid macular edema 1.830E-4 2.523E-3 1.719E-2
9.335E-2
 3 101
37 HP:0007894 Hypopigmentation of the fundus 1.830E-4 2.523E-3 1.719E-2
9.335E-2
 3 101
38 HP:0040049 Macular edema 1.885E-4 2.530E-3 1.723E-2
9.613E-2
 3 102
39 HP:0030498 Macular thickening 1.997E-4 2.546E-3 1.735E-2
1.019E-1
 3 104
40 HP:0001927 Acanthocytosis 1.997E-4 2.546E-3 1.735E-2
1.019E-1
 3 104
41 HP:0010981 Hypolipoproteinemia 2.055E-4 2.556E-3 1.741E-2
1.048E-1
 3 105
42 HP:0007875 Congenital blindness 2.114E-4 2.567E-3 1.749E-2
1.078E-1
 3 106
43 HP:0000408 Progressive sensorineural hearing impairment 2.297E-4 2.675E-3 1.822E-2
1.171E-1
 3 109
44 HP:0000563 Keratoconus 2.360E-4 2.675E-3 1.822E-2
1.204E-1
 3 110
45 HP:0100692 Increased corneal curvature 2.360E-4 2.675E-3 1.822E-2
1.204E-1
 3 110
46 HP:0008527 Congenital sensorineural hearing impairment 2.557E-4 2.774E-3 1.890E-2
1.304E-1
 3 113
47 HP:0001729 Congenital hearing loss 2.557E-4 2.774E-3 1.890E-2
1.304E-1
 3 113
48 HP:0001133 Constriction of peripheral visual field 2.624E-4 2.788E-3 1.900E-2
1.338E-1
 3 114
49 HP:0011958 Retinal perforation 2.764E-4 2.876E-3 1.960E-2
1.409E-1
 3 116
50 HP:0100887 Abnormality of globe size 3.068E-4 3.069E-3 2.091E-2
1.565E-1
 4 327
Show 45 more annotations

5: Mouse Phenotype [Display Chart] 17 input genes in category / 679 annotations before applied cutoff / 10355 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 MP:0000230 abnormal systemic arterial blood pressure 2.269E-6 1.541E-3 1.094E-2 1.541E-3 6 259
2 MP:0002843 decreased systemic arterial blood pressure 3.633E-5 1.153E-2
8.182E-2
 2.467E-2 4 120
3 MP:0005620 abnormal muscle contractility 5.093E-5 1.153E-2
8.182E-2
 3.458E-2 6 446
4 MP:0011148 decreased mesenchymal cell proliferation involved in lung development 9.071E-5 1.533E-2
1.088E-1
6.160E-2
 2 9
5 MP:0000250 abnormal vasoconstriction 1.129E-4 1.533E-2
1.088E-1
7.665E-2
 3 59
6 MP:0003011 delayed dark adaptation 1.658E-4 1.609E-2
1.142E-1
1.126E-1
 2 12
7 MP:0001999 photosensitivity 1.658E-4 1.609E-2
1.142E-1
1.126E-1
 2 12
8 MP:0010993 decreased surfactant secretion 2.282E-4 1.699E-2
1.206E-1
1.549E-1
 2 14
9 MP:0002332 abnormal exercise endurance 2.591E-4 1.699E-2
1.206E-1
1.759E-1
 3 78
10 MP:0000966 decreased sensory neuron number 2.741E-4 1.699E-2
1.206E-1
1.861E-1
 4 202
11 MP:0011232 abnormal vitamin A level 3.003E-4 1.699E-2
1.206E-1
2.039E-1
 2 16
12 MP:0011146 abnormal mesenchymal cell proliferation involved in lung development 3.003E-4 1.699E-2
1.206E-1
2.039E-1
 2 16
13 MP:0002274 abnormal type I pneumocyte morphology 5.748E-4 3.002E-2
2.131E-1
3.903E-1
 2 22
14 MP:0011143 thick lung-associated mesenchyme 6.290E-4 3.050E-2
2.165E-1
4.271E-1
 2 23
15 MP:0005631 decreased lung weight 6.855E-4 3.103E-2
2.203E-1
4.654E-1
 2 24
16 MP:0003026 decreased vasoconstriction 8.692E-4 3.689E-2
2.618E-1
5.902E-1
 2 27
17 MP:0001404 no spontaneous movement 1.003E-3 3.818E-2
2.711E-1
6.814E-1
 2 29
18 MP:0012143 decreased a wave amplitude 1.147E-3 3.818E-2
2.711E-1
7.789E-1
 2 31
19 MP:0008779 abnormal maternal behavior 1.235E-3 3.818E-2
2.711E-1
8.384E-1
 3 133
20 MP:0012030 abnormal a wave amplitude 1.300E-3 3.818E-2
2.711E-1
8.827E-1
 2 33
21 MP:0010813 abnormal alveolar lamellar body morphology 1.300E-3 3.818E-2
2.711E-1
8.827E-1
 2 33
22 MP:0009379 abnormal foot pigmentation 1.300E-3 3.818E-2
2.711E-1
8.827E-1
 2 33
23 MP:0005591 decreased vasodilation 1.380E-3 3.818E-2
2.711E-1
9.370E-1
 2 34
24 MP:0012034 abnormal a wave shape 1.380E-3 3.818E-2
2.711E-1
9.370E-1
 2 34
25 MP:0002972 abnormal cardiac muscle contractility 1.427E-3 3.818E-2
2.711E-1
9.688E-1
 4 313
26 MP:0004876 decreased mean systemic arterial blood pressure 1.462E-3 3.818E-2
2.711E-1
9.928E-1
 2 35
27 MP:0012144 decreased b wave amplitude 1.633E-3 4.108E-2
2.916E-1
1.000E0
 2 37
28 MP:0012035 abnormal b-wave shape 1.814E-3 4.167E-2
2.958E-1
1.000E0
 2 39
29 MP:0012031 abnormal b wave amplitude 1.814E-3 4.167E-2
2.958E-1
1.000E0
 2 39
30 MP:0010825 abnormal lung saccule morphology 1.908E-3 4.167E-2
2.958E-1
1.000E0
 2 40
31 MP:0004780 abnormal surfactant secretion 1.908E-3 4.167E-2
2.958E-1
1.000E0
 2 40
32 MP:0000738 impaired muscle contractility 1.978E-3 4.167E-2
2.958E-1
1.000E0
 4 342
33 MP:0005595 abnormal vascular smooth muscle physiology 2.025E-3 4.167E-2
2.958E-1
1.000E0
 3 158
34 MP:0002842 increased systemic arterial blood pressure 2.100E-3 4.193E-2
2.976E-1
1.000E0
 3 160
35 MP:0005401 abnormal fat-soluble vitamin level 2.305E-3 4.229E-2
3.002E-1
1.000E0
 2 44
36 MP:0006309 decreased retinal ganglion cell number 2.305E-3 4.229E-2
3.002E-1
1.000E0
 2 44
37 MP:0005174 abnormal tail pigmentation 2.305E-3 4.229E-2
3.002E-1
1.000E0
 2 44
38 MP:0006069 abnormal retinal neuronal layer morphology 2.485E-3 4.381E-2
3.110E-1
1.000E0
 4 364
39 MP:0000740 impaired smooth muscle contractility 2.517E-3 4.381E-2
3.110E-1
1.000E0
 2 46
40 MP:0002068 abnormal parental behavior 2.710E-3 4.600E-2
3.265E-1
1.000E0
 3 175
41 MP:0030005 increased retinal apoptosis 2.851E-3 4.612E-2
3.274E-1
1.000E0
 2 49
42 MP:0006264 decreased systemic arterial systolic blood pressure 3.085E-3 4.612E-2
3.274E-1
1.000E0
 2 51
43 MP:0009750 impaired behavioral response to addictive substance 3.085E-3 4.612E-2
3.274E-1
1.000E0
 2 51
44 MP:0004782 abnormal surfactant physiology 3.085E-3 4.612E-2
3.274E-1
1.000E0
 2 51
45 MP:0009638 abnormal pretectal nuclei morphology 3.281E-3 4.612E-2
3.274E-1
1.000E0
 1 2
46 MP:0020106 decreased nitrate level 3.281E-3 4.612E-2
3.274E-1
1.000E0
 1 2
47 MP:0009639 abnormal olivary pretectal nucleus morphology 3.281E-3 4.612E-2
3.274E-1
1.000E0
 1 2
48 MP:0020104 abnormal nitrate level 3.281E-3 4.612E-2
3.274E-1
1.000E0
 1 2
49 MP:0005599 increased cardiac muscle contractility 3.328E-3 4.612E-2
3.274E-1
1.000E0
 2 53
50 MP:0003224 neuron degeneration 3.404E-3 4.623E-2
3.281E-1
1.000E0
 4 397
Show 45 more annotations

6: Domain [Display Chart] 18 input genes in category / 73 annotations before applied cutoff / 18735 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 SM01381 7TM GPCR Srsx SMART 6.981E-10 5.096E-8 2.484E-7 5.096E-8 6 112
2 IPR027430 Retinal BS InterPro 4.158E-8 1.517E-6 7.397E-6 3.035E-6 3 8
3 IPR002233 ADR fam InterPro 8.898E-8 1.624E-6 7.916E-6 6.496E-6 3 10
4 PS00238 OPSIN PROSITE 8.898E-8 1.624E-6 7.916E-6 6.496E-6 3 10
5 IPR001760 Opsin InterPro 1.223E-7 1.785E-6 8.702E-6 8.926E-6 3 11
6 IPR000698 Arrestin InterPro 5.225E-6 3.814E-5 1.859E-4 3.814E-4 2 4
7 PS00295 ARRESTINS PROSITE 5.225E-6 3.814E-5 1.859E-4 3.814E-4 2 4
8 2.60.40.840 - Gene3D 5.225E-6 3.814E-5 1.859E-4 3.814E-4 2 4
9 IPR017864 Arrestin CS InterPro 5.225E-6 3.814E-5 1.859E-4 3.814E-4 2 4
10 IPR014753 Arrestin N InterPro 5.225E-6 3.814E-5 1.859E-4 3.814E-4 2 4
11 2.60.40.640 - Gene3D 1.826E-5 1.212E-4 5.906E-4 1.333E-3 2 7
12 IPR014752 Arrestin C InterPro 2.433E-5 1.480E-4 7.214E-4 1.776E-3 2 8
13 IPR011021 Arrestin-like N InterPro 3.905E-5 1.677E-4 8.175E-4 2.851E-3 2 10
14 SM01017 Arrestin C SMART 3.905E-5 1.677E-4 8.175E-4 2.851E-3 2 10
15 IPR011022 Arrestin C-like InterPro 3.905E-5 1.677E-4 8.175E-4 2.851E-3 2 10
16 PF02752 Arrestin C Pfam 3.905E-5 1.677E-4 8.175E-4 2.851E-3 2 10
17 PF00339 Arrestin N Pfam 3.905E-5 1.677E-4 8.175E-4 2.851E-3 2 10
18 IPR013122 PKD1 2 channel InterPro 4.771E-5 1.833E-4 8.935E-4 3.483E-3 2 11
19 PF08016 PKD channel Pfam 4.771E-5 1.833E-4 8.935E-4 3.483E-3 2 11
20 IPR019477 Rhodopsin N InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
21 IPR001793 RPE GPCR InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
22 IPR000732 Rhodopsin InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
23 IPR020279 Apelin receptor C InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
24 PF10413 Rhodopsin N Pfam 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
25 IPR005951 ABCA4/ABCR InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
26 IPR000332 ADRB2 rcpt InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
27 IPR003904 APJ rcpt InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
28 IPR001115 ADRA1B rcpt InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
29 IPR000363 ADRA1D rcpt InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
30 IPR028536 Dpep1 InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
31 IPR029598 Cep152 InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
32 IPR001642 NeuroB rcpt InterPro 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
33 4.10.840.10 - Gene3D 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
34 PD061381 Apelin receptor C ProDom 9.608E-4 2.063E-3 1.006E-2
7.014E-2
 1 1
35 IPR024888 RRM U1 A/B'' InterPro 1.921E-3 4.006E-3 1.953E-2
1.402E-1
 1 2
36 IPR000180 Dipep AS InterPro 2.880E-3 5.127E-3 2.499E-2
2.102E-1
 1 3
37 IPR008257 Renal dipep fam InterPro 2.880E-3 5.127E-3 2.499E-2
2.102E-1
 1 3
38 PS00869 RENAL DIPEPTIDASE 1 PROSITE 2.880E-3 5.127E-3 2.499E-2
2.102E-1
 1 3
39 PF01244 Peptidase M19 Pfam 2.880E-3 5.127E-3 2.499E-2
2.102E-1
 1 3
40 PS51365 RENAL DIPEPTIDASE 2 PROSITE 2.880E-3 5.127E-3 2.499E-2
2.102E-1
 1 3
41 IPR001556 Bombsn rcpt-like InterPro 2.880E-3 5.127E-3 2.499E-2
2.102E-1
 1 3
42 IPR000654 Gprotein alpha Q InterPro 3.838E-3 6.671E-3 3.252E-2
2.802E-1
 1 4
43 IPR014756 Ig E-set InterPro 4.406E-3 7.481E-3 3.646E-2
3.217E-1
 2 104
44 IPR005821 Ion trans dom InterPro 5.269E-3 8.548E-3 4.167E-2
3.846E-1
 2 114
45 PF00520 Ion trans Pfam 5.269E-3 8.548E-3 4.167E-2
3.846E-1
 2 114
46 IPR026082 ABC A InterPro 1.147E-2 1.821E-2
8.874E-2
8.374E-1
 1 12
47 SM00275 G alpha SMART 1.527E-2 2.229E-2
1.087E-1
1.000E0
 1 16
48 IPR011025 GproteinA insert InterPro 1.527E-2 2.229E-2
1.087E-1
1.000E0
 1 16
49 1.10.400.10 - Gene3D 1.527E-2 2.229E-2
1.087E-1
1.000E0
 1 16
50 PF00503 G-alpha Pfam 1.527E-2 2.229E-2
1.087E-1
1.000E0
 1 16
Show 45 more annotations

7: Pathway [Display Chart] 17 input genes in category / 226 annotations before applied cutoff / 12450 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1269545 Class A/1 (Rhodopsin-like receptors) BioSystems: REACTOME 3.644E-9 8.236E-7 4.941E-6 8.236E-7 8 322
2 P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway PantherDB 3.070E-8 3.076E-6 1.846E-5 6.937E-6 6 150
3 1269592 Gastrin-CREB signalling pathway via PKC and MAPK BioSystems: REACTOME 4.662E-8 3.076E-6 1.846E-5 1.054E-5 8 446
4 1269544 GPCR ligand binding BioSystems: REACTOME 5.444E-8 3.076E-6 1.846E-5 1.230E-5 8 455
5 1269578 G alpha (q) signalling events BioSystems: REACTOME 1.337E-7 5.706E-6 3.424E-5 3.021E-5 6 192
6 1269568 Opsins BioSystems: REACTOME 1.767E-7 5.706E-6 3.424E-5 3.994E-5 3 9
7 1269555 Adrenoceptors BioSystems: REACTOME 1.767E-7 5.706E-6 3.424E-5 3.994E-5 3 9
8 PW:0000229 G protein signaling via Galphaq family Pathway Ontology 7.627E-7 2.154E-5 1.293E-4 1.724E-4 3 14
9 983748 cGMP-PKG signaling pathway BioSystems: KEGG 1.971E-6 4.950E-5 2.970E-4 4.455E-4 5 163
10 153376 Salivary secretion BioSystems: KEGG 5.656E-6 1.278E-4 7.669E-4 1.278E-3 4 90
11 1269356 Thrombin signalling through proteinase activated receptors (PARs) BioSystems: REACTOME 1.024E-5 2.103E-4 1.262E-3 2.313E-3 3 32
12 138034 Arf6 signaling events BioSystems: Pathway Interaction Database 1.233E-5 2.322E-4 1.393E-3 2.786E-3 3 34
13 P05911 Angiotensin II-stimulated signaling through G proteins and beta-arrestin PantherDB 1.347E-5 2.342E-4 1.405E-3 3.045E-3 3 35
14 1269553 Amine ligand-binding receptors BioSystems: REACTOME 2.523E-5 4.006E-4 2.403E-3 5.702E-3 3 43
15 83053 Neuroactive ligand-receptor interaction BioSystems: KEGG 2.659E-5 4.006E-4 2.403E-3 6.009E-3 5 278
16 908257 Adrenergic signaling in cardiomyocytes BioSystems: KEGG 3.634E-5 5.133E-4 3.080E-3 8.213E-3 4 144
17 83050 Calcium signaling pathway BioSystems: KEGG 9.061E-5 1.205E-3 7.228E-3 2.048E-2 4 182
18 1269642 Activation of SMO BioSystems: REACTOME 2.651E-4 3.328E-3 1.997E-2
5.991E-2
 2 18
19 1427859 Cargo recognition for clathrin-mediated endocytosis BioSystems: REACTOME 3.059E-4 3.638E-3 2.183E-2
6.913E-2
 3 99
20 1269625 The canonical retinoid cycle in rods (twilight vision) BioSystems: REACTOME 4.366E-4 4.933E-3 2.960E-2
9.867E-2
 2 23
21 1269954 TRP channels BioSystems: REACTOME 5.168E-4 5.562E-3 3.337E-2
1.168E-1
 2 25
22 96530 Vascular smooth muscle contraction BioSystems: KEGG 5.513E-4 5.663E-3 3.398E-2
1.246E-1
 3 121
23 M2701 Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. MSigDB C2 BIOCARTA (v6.0) 6.037E-4 5.932E-3 3.559E-2
1.364E-1
 2 27
24 1427858 Clathrin-mediated endocytosis BioSystems: REACTOME 7.917E-4 7.207E-3 4.324E-2
1.789E-1
 3 137
25 1269536 Activated NOTCH1 Transmits Signal to the Nucleus BioSystems: REACTOME 7.973E-4 7.207E-3 4.324E-2
1.802E-1
 2 31
26 1269575 G alpha (s) signalling events BioSystems: REACTOME 9.523E-4 8.277E-3 4.966E-2
2.152E-1
 3 146
27 1457783 Signaling by high-kinase activity BRAF mutants BioSystems: REACTOME 1.017E-3 8.512E-3
5.107E-2
2.298E-1
 2 35
28 1269287 MAP2K and MAPK activation BioSystems: REACTOME 1.262E-3 9.510E-3
5.706E-2
2.853E-1
 2 39
29 1457785 Paradoxical activation of RAF signaling by kinase inactive BRAF BioSystems: REACTOME 1.262E-3 9.510E-3
5.706E-2
2.853E-1
 2 39
30 1457784 Signaling by moderate kinase activity BRAF mutants BioSystems: REACTOME 1.262E-3 9.510E-3
5.706E-2
2.853E-1
 2 39
31 83063 Hedgehog signaling pathway BioSystems: KEGG 1.830E-3 1.334E-2
8.004E-2
4.135E-1
 2 47
32 1457782 Signaling by RAS mutants BioSystems: REACTOME 2.151E-3 1.519E-2
9.116E-2
4.862E-1
 2 51
33 1457786 Signaling by BRAF and RAF fusions BioSystems: REACTOME 3.063E-3 2.098E-2
1.259E-1
6.922E-1
 2 61
34 1427862 Ub-specific processing proteases BioSystems: REACTOME 3.284E-3 2.179E-2
1.307E-1
7.422E-1
 3 225
35 137928 LPA receptor mediated events BioSystems: Pathway Interaction Database 3.470E-3 2.179E-2
1.307E-1
7.843E-1
 2 65
36 1222951 Renin secretion BioSystems: KEGG 3.470E-3 2.179E-2
1.307E-1
7.843E-1
 2 65
37 1269576 G alpha (i) signalling events BioSystems: REACTOME 4.079E-3 2.433E-2
1.460E-1
9.218E-1
 3 243
38 PW:0000459 apelin signaling Pathway Ontology 4.091E-3 2.433E-2
1.460E-1
9.246E-1
 1 3
39 1269535 Signaling by NOTCH1 BioSystems: REACTOME 4.474E-3 2.593E-2
1.556E-1
1.000E0
 2 74
40 1457781 Oncogenic MAPK signaling BioSystems: REACTOME 4.713E-3 2.663E-2
1.598E-1
1.000E0
 2 76
41 102279 Endocytosis BioSystems: KEGG 4.929E-3 2.717E-2
1.630E-1
1.000E0
 3 260
42 PW:0000494 oxytocin signaling Pathway Ontology 5.451E-3 2.933E-2
1.760E-1
1.000E0
 1 4
43 1269350 Platelet activation, signaling and aggregation BioSystems: REACTOME 6.178E-3 3.206E-2
1.924E-1
1.000E0
 3 282
44 1269640 Hedgehog 'on' state BioSystems: REACTOME 6.409E-3 3.206E-2
1.924E-1
1.000E0
 2 89
45 1269579 G alpha (12/13) signalling events BioSystems: REACTOME 6.550E-3 3.206E-2
1.924E-1
1.000E0
 2 90
46 552665 Morphine addiction BioSystems: KEGG 6.691E-3 3.206E-2
1.924E-1
1.000E0
 2 91
47 PW:0000712 vasopressin signaling pathway via receptor type 1 Pathway Ontology 6.810E-3 3.206E-2
1.924E-1
1.000E0
 1 5
48 545300 leukotriene biosynthesis BioSystems: BIOCYC 6.810E-3 3.206E-2
1.924E-1
1.000E0
 1 5
49 1427860 Deubiquitination BioSystems: REACTOME 7.535E-3 3.468E-2
2.081E-1
1.000E0
 3 303
50 P00057 Wnt signaling pathway PantherDB 7.672E-3 3.468E-2
2.081E-1
1.000E0
 3 305
Show 45 more annotations

8: Pubmed [Display Chart] 18 input genes in category / 4115 annotations before applied cutoff / 38193 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 18240029 Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. Pubmed 1.153E-16 4.743E-13 4.221E-12 4.743E-13 9 200
2 25658948 Quantification of beta adrenergic receptor subtypes in beta-arrestin knockout mouse airways. Pubmed 8.789E-11 1.206E-7 1.073E-6 3.617E-7 3 3
3 23302795 Analysis of temporal patterns of GPCR-β-arrestin interactions using split luciferase-fragment complementation. Pubmed 8.789E-11 1.206E-7 1.073E-6 3.617E-7 3 3
4 11588219 Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and beta-arrestin. Pubmed 3.514E-10 2.410E-7 2.145E-6 1.446E-6 3 4
5 24947582 A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1. Pubmed 3.514E-10 2.410E-7 2.145E-6 1.446E-6 3 4
6 15611106 beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation. Pubmed 3.514E-10 2.410E-7 2.145E-6 1.446E-6 3 4
7 16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells. Pubmed 7.147E-10 3.614E-7 3.217E-6 2.941E-6 5 95
8 12573668 Expression of opsin genes early in ocular development of humans and mice. Pubmed 8.784E-10 3.614E-7 3.217E-6 3.614E-6 3 5
9 2154750 Chromosomal organization of adrenergic receptor genes. Pubmed 8.784E-10 3.614E-7 3.217E-6 3.614E-6 3 5
10 21857681 A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. Pubmed 8.784E-10 3.614E-7 3.217E-6 3.614E-6 3 5
11 12184796 Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells. Pubmed 1.756E-9 5.559E-7 4.947E-6 7.227E-6 3 6
12 18544533 Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor. Pubmed 1.756E-9 5.559E-7 4.947E-6 7.227E-6 3 6
13 23208550 Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking. Pubmed 1.756E-9 5.559E-7 4.947E-6 7.227E-6 3 6
14 23166351 MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors. Pubmed 3.072E-9 8.429E-7 7.501E-6 1.264E-5 3 7
15 20886089 GPR54 regulates ERK1/2 activity and hypothalamic gene expression in a Gα(q/11) and β-arrestin-dependent manner. Pubmed 3.072E-9 8.429E-7 7.501E-6 1.264E-5 3 7
16 19372219 Mdm2 directs the ubiquitination of beta-arrestin-sequestered cAMP phosphodiesterase-4D5. Pubmed 4.914E-9 1.190E-6 1.059E-5 2.022E-5 3 8
17 9139936 Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. Pubmed 4.914E-9 1.190E-6 1.059E-5 2.022E-5 3 8
18 17846866 The N-terminal coiled-coil domain of the cytohesin/ARNO family of guanine nucleotide exchange factors interacts with Galphaq. Pubmed 7.369E-9 1.596E-6 1.420E-5 3.033E-5 3 9
19 21209093 Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. Pubmed 7.369E-9 1.596E-6 1.420E-5 3.033E-5 3 9
20 23236378 Mammalian α arrestins link activated seven transmembrane receptors to Nedd4 family e3 ubiquitin ligases and interact with β arrestins. Pubmed 3.189E-8 6.561E-6 5.839E-5 1.312E-4 3 14
21 1676978 Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. Pubmed 5.952E-8 1.066E-5 9.485E-5 2.449E-4 3 17
22 20591486 Development of a diagnostic genetic test for simplex and autosomal recessive retinitis pigmentosa. Pubmed 7.140E-8 1.066E-5 9.485E-5 2.938E-4 3 18
23 26965927 Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line. Pubmed 8.476E-8 1.066E-5 9.485E-5 3.488E-4 3 19
24 19855129 Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. Pubmed 1.547E-7 1.066E-5 9.485E-5 6.367E-4 3 23
25 25775587 Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Pubmed 2.008E-7 1.066E-5 9.485E-5 8.264E-4 3 25
26 22753890 Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
27 17360618 Each rhodopsin molecule binds its own arrestin. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
28 26103985 Specificity of arrestin subtypes in regulating airway smooth muscle G protein-coupled receptor signaling and function. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
29 12582207 Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
30 17594911 The role of beta-arrestins in the formyl peptide receptor-like 1 internalization and signaling. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
31 23287463 Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
32 26077142 β-Arrestin1 enhances hepatocellular carcinogenesis through inflammation-mediated Akt signalling. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
33 18801735 Dual role of the beta2-adrenergic receptor C terminus for the binding of beta-arrestin and receptor internalization. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
34 29395480 Melanopsin and rhodopsin mediate UVA-induced immediate pigment darkening: Unravelling the photosensitive system of the skin. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
35 11171997 beta-Arrestin 1 and 2 differentially regulate heptahelical receptor signaling and trafficking. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
36 14736874 Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
37 24299002 Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
38 25134464 β-Arrestins regulate human cardiac fibroblast transformation and collagen synthesis in adverse ventricular remodeling. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
39 21411739 β-arrestin deficiency protects against pulmonary fibrosis in mice and prevents fibroblast invasion of extracellular matrix. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
40 16380388 Selective loss of fine tuning of Gq/11 signaling by RGS2 protein exacerbates cardiomyocyte hypertrophy. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
41 20353754 The fate of the internalized apelin receptor is determined by different isoforms of apelin mediating differential interaction with beta-arrestin. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
42 18703513 Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
43 21543334 Beta-arrestin-1 protein represses diet-induced obesity. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
44 22699970 β-Arrestin prevents cell apoptosis through pro-apoptotic ERK1/2 and p38 MAPKs and anti-apoptotic Akt pathways. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
45 19896992 beta-Arrestins modulate Adenovirus-vector-induced innate immune responses: differential regulation by beta-arrestin-1 and beta-arrestin-2. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
46 18519945 Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
47 9668034 G protein-coupled receptors. III. New roles for receptor kinases and beta-arrestins in receptor signaling and desensitization. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
48 27815373 Inhibiting Insulin-Mediated β2-Adrenergic Receptor Activation Prevents Diabetes-Associated Cardiac Dysfunction. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
49 10820200 Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
50 7932878 Light-dependent regulation of the transcriptional activity of the mammalian gene for arrestin. Pubmed 2.098E-7 1.066E-5 9.485E-5 8.632E-4 2 2
Show 45 more annotations

9: Interaction [Display Chart] 18 input genes in category / 1363 annotations before applied cutoff / 17703 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 int:SAG SAG interactions 1.121E-11 1.051E-8 8.191E-8 1.527E-8 4 6
2 int:ARR3 ARR3 interactions 1.542E-11 1.051E-8 8.191E-8 2.102E-8 5 22
3 int:GRK2 GRK2 interactions 1.119E-8 5.082E-6 3.961E-5 1.525E-5 5 77
4 int:ARRDC4 ARRDC4 interactions 1.054E-7 3.593E-5 2.801E-4 1.437E-4 3 10
5 int:ADRA1A ADRA1A interactions 1.449E-7 3.950E-5 3.079E-4 1.975E-4 3 11
6 int:MCOLN2 MCOLN2 interactions 9.765E-7 2.195E-4 1.711E-3 1.331E-3 2 2
7 int:CSK CSK interactions 1.127E-6 2.195E-4 1.711E-3 1.537E-3 4 80
8 int:CYTH1 CYTH1 interactions 1.343E-6 2.288E-4 1.783E-3 1.830E-3 3 22
9 int:OPRD1 OPRD1 interactions 2.543E-6 3.851E-4 3.002E-3 3.466E-3 3 27
10 int:CYTH2 CYTH2 interactions 5.179E-6 7.058E-4 5.502E-3 7.058E-3 3 34
11 int:ADGRG1 ADGRG1 interactions 9.747E-6 1.036E-3 8.078E-3 1.329E-2 2 5
12 int:HCRTR1 HCRTR1 interactions 9.747E-6 1.036E-3 8.078E-3 1.329E-2 2 5
13 int:NOS1 NOS1 interactions 9.884E-6 1.036E-3 8.078E-3 1.347E-2 3 42
14 int:PTGER4 PTGER4 interactions 1.461E-5 1.264E-3 9.851E-3 1.992E-2 2 6
15 int:SLC9A5 SLC9A5 interactions 1.461E-5 1.264E-3 9.851E-3 1.992E-2 2 6
16 int:USP33 USP33 interactions 1.484E-5 1.264E-3 9.851E-3 2.022E-2 3 48
17 int:ARRDC3 ARRDC3 interactions 1.891E-5 1.516E-3 1.182E-2 2.577E-2 3 52
18 int:APLN APLN interactions 2.044E-5 1.548E-3 1.207E-2 2.786E-2 2 7
19 int:RGS5 RGS5 interactions 2.724E-5 1.954E-3 1.523E-2 3.713E-2 2 8
20 int:C5AR1 C5AR1 interactions 4.373E-5 2.878E-3 2.243E-2
5.960E-2
 2 10
21 int:CLTA CLTA interactions 4.434E-5 2.878E-3 2.243E-2
6.044E-2
 3 69
22 int:CALM3 CALM3 interactions 4.831E-5 2.986E-3 2.327E-2
6.585E-2
 3 71
23 int:RGS2 RGS2 interactions 5.038E-5 2.986E-3 2.327E-2
6.867E-2
 3 72
24 int:KBTBD8 KBTBD8 interactions 6.406E-5 3.358E-3 2.618E-2
8.731E-2
 2 12
25 int:GRK1 GRK1 interactions 6.406E-5 3.358E-3 2.618E-2
8.731E-2
 2 12
26 int:ELOVL5 ELOVL5 interactions 6.406E-5 3.358E-3 2.618E-2
8.731E-2
 2 12
27 int:ARF6 ARF6 interactions 7.434E-5 3.437E-3 2.680E-2
1.013E-1
 3 82
28 int:DRD4 DRD4 interactions 7.566E-5 3.437E-3 2.680E-2
1.031E-1
 2 13
29 int:ADRA1B ADRA1B interactions 7.566E-5 3.437E-3 2.680E-2
1.031E-1
 2 13
30 int:PTAFR PTAFR interactions 7.566E-5 3.437E-3 2.680E-2
1.031E-1
 2 13
31 int:HSPA1B HSPA1B interactions 9.490E-5 4.173E-3 3.253E-2
1.293E-1
 3 89
32 int:RHO RHO interactions 1.017E-4 4.333E-3 3.378E-2
1.387E-1
 2 15
33 int:ADRB2 ADRB2 interactions 1.183E-4 4.886E-3 3.808E-2
1.612E-1
 4 260
34 int:DGKE DGKE interactions 1.316E-4 5.225E-3 4.073E-2
1.794E-1
 2 17
35 int:GNAQ GNAQ interactions 1.342E-4 5.225E-3 4.073E-2
1.829E-1
 3 100
36 int:ADRB1 ADRB1 interactions 1.480E-4 5.451E-3 4.249E-2
2.017E-1
 2 18
37 int:MC1R MC1R interactions 1.480E-4 5.451E-3 4.249E-2
2.017E-1
 2 18
38 int:GNAS GNAS interactions 1.551E-4 5.562E-3 4.336E-2
2.114E-1
 3 105
39 int:HIST1H2BO HIST1H2BO interactions 2.027E-4 6.908E-3
5.385E-2
2.763E-1
 2 21
40 int:NT5C3A NT5C3A interactions 2.027E-4 6.908E-3
5.385E-2
2.763E-1
 2 21
41 int:SDC3 SDC3 interactions 2.439E-4 8.109E-3
6.321E-2
3.325E-1
 2 23
42 int:PFKFB3 PFKFB3 interactions 2.660E-4 8.430E-3
6.571E-2
3.625E-1
 2 24
43 int:GNA15 GNA15 interactions 2.660E-4 8.430E-3
6.571E-2
3.625E-1
 2 24
44 int:GNB1 GNB1 interactions 2.783E-4 8.620E-3
6.720E-2
3.793E-1
 3 128
45 int:BRPF1 BRPF1 interactions 2.889E-4 8.751E-3
6.821E-2
3.938E-1
 2 25
46 int:EDNRA EDNRA interactions 3.128E-4 9.268E-3
7.225E-2
4.263E-1
 2 26
47 int:CSN2 CSN2 interactions 3.376E-4 9.791E-3
7.632E-2
4.602E-1
 2 27
48 int:NOP10 NOP10 interactions 3.900E-4 1.074E-2
8.374E-2
5.316E-1
 2 29
49 int:DGKZ DGKZ interactions 3.900E-4 1.074E-2
8.374E-2
5.316E-1
 2 29
50 int:ALG8 ALG8 interactions 4.177E-4 1.074E-2
8.374E-2
5.693E-1
 2 30
Show 45 more annotations

10: Cytoband [Display Chart] 18 input genes in category / 17 annotations before applied cutoff / 34661 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 1p22 1p22 4.813E-5 8.182E-4 2.814E-3 8.182E-4 2 20
2 5q31-q32 5q31-q32 2.076E-3 1.176E-2 4.046E-2 3.529E-2 1 4
3 3q21-q24 3q21-q24 2.076E-3 1.176E-2 4.046E-2 3.529E-2 1 4
4 9q21 9q21 5.698E-3 2.147E-2
7.385E-2
9.687E-2
 1 11
5 10q23 10q23 6.731E-3 2.147E-2
7.385E-2
1.144E-1
 1 13
6 1q31 1q31 9.824E-3 2.147E-2
7.385E-2
1.670E-1
 1 19
7 10q22 10q22 9.824E-3 2.147E-2
7.385E-2
1.670E-1
 1 19
8 11q12 11q12 1.085E-2 2.147E-2
7.385E-2
1.845E-1
 1 21
9 1p22.3 1p22.3 1.137E-2 2.147E-2
7.385E-2
1.932E-1
 1 22
10 5q33.3 5q33.3 1.854E-2 2.943E-2
1.012E-1
3.151E-1
 1 36
11 17p13 17p13 1.905E-2 2.943E-2
1.012E-1
3.238E-1
 1 37
12 15q21.1 15q21.1 2.108E-2 2.987E-2
1.027E-1
3.584E-1
 1 41
13 8p12 8p12 2.515E-2 3.289E-2
1.131E-1
4.275E-1
 1 49
14 16q24.3 16q24.3 2.869E-2 3.484E-2
1.198E-1
4.878E-1
 1 56
Show 9 more annotations

11: Transcription Factor Binding Site [Display Chart] 14 input genes in category / 88 annotations before applied cutoff / 9770 genes in category

No results to display

12: Gene Family [Display Chart] 15 input genes in category / 10 annotations before applied cutoff / 18194 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 169 Adrenoceptors genenames.org 3.797E-8 3.725E-7 1.091E-6 3.797E-7 3 9
2 215 Opsin receptors|Protein phosphatase 1 regulatory subunits genenames.org 7.451E-8 3.725E-7 1.091E-6 7.451E-7 3 11
3 1312 Classical arrestins genenames.org 3.803E-6 1.268E-5 3.713E-5 3.803E-5 2 4
4 249 Transient receptor potential cation channels|Ankyrin repeat domain containing genenames.org 2.369E-4 5.922E-4 1.734E-3 2.369E-3 2 28
5 222 Bombesin receptors genenames.org 2.471E-3 4.943E-3 1.448E-2 2.471E-2 1 3
6 220 Peptide receptors genenames.org 5.758E-3 9.596E-3 2.811E-2
5.758E-2
 1 7
7 805 ATP binding cassette subfamily A genenames.org 1.148E-2 1.641E-2 4.805E-2
1.148E-1
 1 14
8 720 Regulators of G-protein signaling genenames.org 1.718E-2 2.148E-2
6.290E-2
1.718E-1
 1 21
Show 3 more annotations

13: Coexpression [Display Chart] 18 input genes in category / 1823 annotations before applied cutoff / 23137 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 19010862-TableS2 Human Breast Laere08 205genes GeneSigDB 3.330E-7 6.071E-4 4.909E-3 6.071E-4 5 197
2 M3028 Genes down-regulated in comparison of naive versus memory CD8 T cells (day 40+ following LCMV-Armstrong infection). MSigDB C7: Immunologic Signatures (v6.0) 1.478E-5 9.162E-3
7.408E-2
 2.695E-2 4 199
3 M5837 Genes down-regulated in comparison of effector CD8 T cells versus memory CD8 T cells. MSigDB C7: Immunologic Signatures (v6.0) 1.508E-5 9.162E-3
7.408E-2
 2.749E-2 4 200
4 M8904 Genes up-regulated in pro-B cells versus granulocyte-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 1.655E-4 3.308E-2
2.675E-1
3.018E-1
 3 140
5 M12595 Class T (tolerizeable) genes: induced during the first LPS stimulation and either not re-induced or induced to a much lesser degree in tolerant macrophages. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.278E-4 3.308E-2
2.675E-1
4.152E-1
 3 156
6 M6880 Genes up-regulated in monocytes after HCMV infection: untreated versus BAY 11-7082 [PubChem=5353431]. MSigDB C7: Immunologic Signatures (v6.0) 2.454E-4 3.308E-2
2.675E-1
4.473E-1
 3 160
7 M9556 Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 48 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.499E-4 3.308E-2
2.675E-1
4.556E-1
 3 161
8 18812439-Table2 Human Breast Yan08 52genes GeneSigDB 2.623E-4 3.308E-2
2.675E-1
4.781E-1
 2 31
9 M16114 Genes down-regulated in HFK cells (primary keratinocytes) in response to UVB irradiation. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.975E-4 3.308E-2
2.675E-1
5.424E-1
 2 33
10 M7429 Genes down-regulated in T98G cells (glioma, express MGMT [GeneID=4255]) by carmustine [PubChem=2578] at 24 h. MSigDB C2: CGP Curated Gene Sets (v6.0) 2.975E-4 3.308E-2
2.675E-1
5.424E-1
 2 33
11 15980968-Table3a Human Brain Bandres05 42genes GeneSigDB 2.975E-4 3.308E-2
2.675E-1
5.424E-1
 2 33
12 M7396 Genes down-regulated in the Kras2LA mouse lung cancer model with mutated KRAS [GeneID=3845]. MSigDB C2: CGP Curated Gene Sets (v6.0) 3.059E-4 3.308E-2
2.675E-1
5.577E-1
 4 435
13 M7930 Genes up-regulated in bone marrow-derived macrophages with STAT6 [GeneID=6778] knockout: control versus treated with IL4 [GeneID=3565]. MSigDB C7: Immunologic Signatures (v6.0) 4.124E-4 3.308E-2
2.675E-1
7.519E-1
 3 191
14 M7459 Genes up-regulated in CD4 [GeneID=920] T cells: medium versus IL6 [GeneID=3569]. MSigDB C7: Immunologic Signatures (v6.0) 4.252E-4 3.308E-2
2.675E-1
7.751E-1
 3 193
15 M12824 Cluster 4 of method A: up-regulation of these genes in patients with non-small cell lung cancer (NSCLC) predicts good survival outcome. MSigDB C2: CGP Curated Gene Sets (v6.0) 4.448E-4 3.308E-2
2.675E-1
8.108E-1
 3 196
16 M4181 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 1 h. MSigDB C7: Immunologic Signatures (v6.0) 4.514E-4 3.308E-2
2.675E-1
8.230E-1
 3 197
17 M4189 Genes up-regulated in comparison of untreated CD4 [GeneID=920] T cells at 0 h versus the cells treated with IL4 [GeneID=3565] and anti-IL12 at 6 h. MSigDB C7: Immunologic Signatures (v6.0) 4.582E-4 3.308E-2
2.675E-1
8.352E-1
 3 198
18 M7453 Genes down-regulated in CD4 [GeneID=920] T cells treated with TGF beta and IL6 [GeneID=3569]: STAT3 [GeneID=6774] knockout versus wildtype. MSigDB C7: Immunologic Signatures (v6.0) 4.649E-4 3.308E-2
2.675E-1
8.476E-1
 3 199
19 M7073 Genes up-regulated in NK cells: primary versus stimulated by low dose of IL2 [GeneID=3558]. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
20 M7025 Genes down-regulated in IKZF1 [GeneID=10320] knockout: hematopoietic stem cells versus granulo-monocyte progenitors. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
21 M9838 Genes up-regulated in CD40L and IL-2 IL-4 IL-5 stimulated at day 1 B cell IRF4high versus CD40L and IL-2 IL-4 IL-5 stimulated at day 3 B cell IRF4high. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
22 M5744 Genes down-regulated in comparison of thymus regulatory T cells versus fat tissue regulatory T cells. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
23 M9062 Genes down-regulated in monocytes treated by rosiglitazone [PubChem=77999]: Ly6C high versus Ly6C low. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
24 M9640 Genes up-regulated in CD4 [GeneID=920] T helper cells (4h): Th0 versus TGFB1 and IL6 [GeneID=7040;3569]. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
25 M5481 Genes up-regulated in comparison of dendritic cells (DC) versus Th1 cells. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
26 M9667 Genes up-regulated in CD4 [GeneID=920] T helper cells Th17 (52h): TGFB1 and IL6 [GeneID=7040;3569] versus TGFB1, IL6 [GeneID=7040;3569] and IL-23. MSigDB C7: Immunologic Signatures (v6.0) 4.718E-4 3.308E-2
2.675E-1
8.601E-1
 3 200
27 M15326 Genes up-regulated in H358 cells (lung cancer) by inducible expression of FOXA2 [GeneID=3170] in a Tet-off system. MSigDB C2: CGP Curated Gene Sets (v6.0) 5.548E-4 3.746E-2
3.029E-1
1.000E0
 2 45
28 M19460 Genes down-regulated in the Ad/AH cells (adenocarcinoma) engineered to stably express the Epstein-Barr virus (EBV) gene EBNA1. MSigDB C2: CGP Curated Gene Sets (v6.0) 6.053E-4 3.941E-2
3.186E-1
1.000E0
 2 47
Show 23 more annotations

14: Coexpression Atlas [Display Chart] 18 input genes in category / 1641 annotations before applied cutoff / 21829 genes in category

No results to display

15: Computational [Display Chart] 14 input genes in category / 62 annotations before applied cutoff / 10037 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 M13751 MODULE 123 Genes in the cancer module 123. MSigDb: C4 - CM: Cancer Modules (v6.0) 2.950E-4 1.060E-2 4.995E-2 1.829E-2 4 247
2 M6672 MODULE 146 Genes in the cancer module 146. MSigDb: C4 - CM: Cancer Modules (v6.0) 3.419E-4 1.060E-2 4.995E-2 2.120E-2 3 102
3 M5552 GNF2 TNFSF10 Neighborhood of TNFSF10 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 7.686E-4 1.588E-2
7.485E-2
 4.765E-2 2 30
4 M13076 GNF2 S100A4 Neighborhood of S100A4 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 1.884E-3 2.852E-2
1.344E-1
1.168E-1
 2 47
5 M1953 GNF2 ITGB2 Neighborhood of ITGB2 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.760E-3 2.852E-2
1.344E-1
1.711E-1
 2 57
6 M1250 GNF2 MCL1 Neighborhood of MCL1 MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 2.760E-3 2.852E-2
1.344E-1
1.711E-1
 2 57
7 M356 GNF2 TNFRSF1B Neighborhood of TNFRSF1B MSigDb: C4 - CGN: Cancer Gene Neighborhood (v6.0) 3.574E-3 3.166E-2
1.492E-1
2.216E-1
 2 65
Show 2 more annotations

16: MicroRNA [Display Chart] 18 input genes in category / 359 annotations before applied cutoff / 72241 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 GGCAGCT,MIR-22:MSigDB GGCAGCT,MIR-22:MSigDB MSigDB 2.139E-5 7.679E-3 4.962E-2 7.679E-3 3 218
2 hsa-miR-21-3p:Functional MTI (Weak) Functional MTI (Weak) miRTarbase 1.972E-4 3.539E-2
2.287E-1
7.078E-2
 2 83

17: Drug [Display Chart] 18 input genes in category / 5275 annotations before applied cutoff / 22841 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 CID000004171 metoprolol Stitch 1.081E-12 5.702E-9 5.216E-8 5.702E-9 7 105
2 CID000023039 Alstonine hydrochloride Stitch 2.659E-10 7.014E-7 6.417E-6 1.403E-6 6 116
3 CID000123981 benalfocin Stitch 1.038E-9 1.826E-6 1.670E-5 5.478E-6 4 19
4 CID004133924 2,2,2-trifluoroethanethiol Stitch 4.105E-9 5.414E-6 4.952E-5 2.165E-5 3 5
5 CID000125847 Br-pindolol Stitch 8.206E-9 8.658E-6 7.920E-5 4.329E-5 3 6
6 CID004038180 A61603 Stitch 1.089E-8 9.294E-6 8.502E-5 5.743E-5 4 33
7 CID000005406 transdihydrolisuride Stitch 1.233E-8 9.294E-6 8.502E-5 6.506E-5 4 34
8 CID000128116 sulfo-SADP Stitch 1.435E-8 9.465E-6 8.658E-5 7.572E-5 3 7
9 CID000002405 bisoprolol Stitch 1.754E-8 1.028E-5 9.404E-5 9.252E-5 4 37
10 CID005287445 AC1NR9P8 Stitch 1.959E-8 1.033E-5 9.454E-5 1.033E-4 4 38
11 DB00668 Epinephrine Drug Bank 2.295E-8 1.101E-5 1.007E-4 1.211E-4 3 8
12 CID003033538 dapiprazole Stitch 3.442E-8 1.440E-5 1.317E-4 1.815E-4 3 9
13 CID000002124 aluminum fluoride Stitch 4.070E-8 1.440E-5 1.317E-4 2.147E-4 6 268
14 CID000072016 efaroxan Stitch 4.314E-8 1.440E-5 1.317E-4 2.276E-4 4 46
15 CID000163952 L-659,066 Stitch 4.914E-8 1.440E-5 1.317E-4 2.592E-4 3 10
16 DB06262 Droxidopa Drug Bank 4.914E-8 1.440E-5 1.317E-4 2.592E-4 3 10
17 CID003084985 DO 710 Stitch 4.914E-8 1.440E-5 1.317E-4 2.592E-4 3 10
18 DB00368 Norepinephrine Drug Bank 4.914E-8 1.440E-5 1.317E-4 2.592E-4 3 10
19 ctd:C043211 carvedilol CTD 5.596E-8 1.554E-5 1.421E-4 2.952E-4 5 136
20 CID000001257 LY 171555 Stitch 6.946E-8 1.832E-5 1.676E-4 3.664E-4 5 142
21 CID000002083 salbutamol Stitch 8.259E-8 2.075E-5 1.898E-4 4.357E-4 5 147
22 CID000004892 SZL-49 Stitch 9.000E-8 2.158E-5 1.974E-4 4.748E-4 3 12
23 CID000033625 indoramin Stitch 1.169E-7 2.682E-5 2.454E-4 6.169E-4 3 13
24 CID000071739 carazolol Stitch 1.280E-7 2.814E-5 2.574E-4 6.754E-4 4 60
25 CID000123679 MK-912 Stitch 1.488E-7 2.819E-5 2.579E-4 7.847E-4 3 14
26 CID000065945 deriglidole Stitch 1.488E-7 2.819E-5 2.579E-4 7.847E-4 3 14
27 CID000092126 3-hydroxy-4-methoxycinnamic acid Stitch 1.488E-7 2.819E-5 2.579E-4 7.847E-4 3 14
28 CID000005631 AC1L1KS5 Stitch 1.496E-7 2.819E-5 2.579E-4 7.894E-4 6 334
29 CID000002475 bupranolol Stitch 1.562E-7 2.841E-5 2.599E-4 8.238E-4 4 63
30 CID003081094 HV723 Stitch 1.859E-7 3.064E-5 2.803E-4 9.804E-4 3 15
31 CID000122295 SKF 104078 Stitch 1.859E-7 3.064E-5 2.803E-4 9.804E-4 3 15
32 CID000002169 amosulalol Stitch 1.859E-7 3.064E-5 2.803E-4 9.804E-4 3 15
33 CID000072036 fluparoxan Stitch 2.286E-7 3.655E-5 3.343E-4 1.206E-3 3 16
34 CID000027833 EEDQ Stitch 2.685E-7 4.009E-5 3.668E-4 1.417E-3 4 72
35 CID000133621 imiloxan Stitch 2.775E-7 4.009E-5 3.668E-4 1.464E-3 3 17
36 CID000004418 naftopidil Stitch 2.775E-7 4.009E-5 3.668E-4 1.464E-3 3 17
37 CID000006436 triamcinolone acetonide Stitch 2.840E-7 4.009E-5 3.668E-4 1.498E-3 4 73
38 CID000001070 11-cis-retinal Stitch 2.888E-7 4.009E-5 3.668E-4 1.524E-3 5 189
39 224 UP retinoic acid; Up 200; 1uM; MCF7; HG-U133A Broad Institute CMAP Up 3.043E-7 4.116E-5 3.765E-4 1.605E-3 5 191
40 CID000004260 thymoxamine Stitch 3.328E-7 4.339E-5 3.970E-4 1.756E-3 3 18
41 CID011957432 Gi-2 Stitch 3.373E-7 4.339E-5 3.970E-4 1.779E-3 5 195
42 CID000004636 oxymetazoline Stitch 3.909E-7 4.736E-5 4.333E-4 2.062E-3 4 79
43 CID003894573 RS-17053 Stitch 3.951E-7 4.736E-5 4.333E-4 2.084E-3 3 19
44 ctd:D000526 Alprenolol CTD 3.951E-7 4.736E-5 4.333E-4 2.084E-3 3 19
45 CID000068864 midaglizole Stitch 4.645E-7 5.327E-5 4.873E-4 2.450E-3 3 20
46 CID000004436 naphazoline Stitch 4.645E-7 5.327E-5 4.873E-4 2.450E-3 3 20
47 CID000001862 6-fluoronorepinephrine Stitch 5.417E-7 5.808E-5 5.313E-4 2.857E-3 3 21
48 CID000002277 B-HT 933 Stitch 5.417E-7 5.808E-5 5.313E-4 2.857E-3 3 21
49 CID000609483 ARC 239 Stitch 5.417E-7 5.808E-5 5.313E-4 2.857E-3 3 21
50 CID000002435 brimonidine Stitch 5.505E-7 5.808E-5 5.313E-4 2.904E-3 4 86
Show 45 more annotations

18: Disease [Display Chart] 17 input genes in category / 527 annotations before applied cutoff / 16205 genes in category

ID Name Source pValue FDR B&H FDR B&Y Bonferroni Genes from Input Genes in Annotation
1 C0017601 Glaucoma DisGeNET Curated 2.833E-7 1.493E-4 1.022E-3 1.493E-4 6 283
2 C0264766 Rheumatic mitral stenosis DisGeNET BeFree 1.550E-5 2.705E-3 1.852E-2 8.168E-3 2 6
3 C4024818 Night blindness, progressive DisGeNET Curated 1.936E-5 2.705E-3 1.852E-2 1.020E-2 3 51
4 C0266423 Congenital anomaly of testis DisGeNET Curated 2.053E-5 2.705E-3 1.852E-2 1.082E-2 3 52
5 C4024753 Abnormality of the retinal vasculature DisGeNET Curated 3.006E-5 3.066E-3 2.099E-2 1.584E-2 3 59
6 C4021786 Atypical scarring of skin DisGeNET Curated 3.491E-5 3.066E-3 2.099E-2 1.840E-2 3 62
7 C1840457 Loss of retinal pigment epithelium DisGeNET Curated 4.638E-5 3.492E-3 2.390E-2 2.444E-2 2 10
8 C1998028 Photoreceptor degeneration DisGeNET BeFree 6.430E-5 3.979E-3 2.723E-2 3.388E-2 3 76
9 C1836926 Fundus with peripheral 'bony spicules' DisGeNET Curated 6.795E-5 3.979E-3 2.723E-2 3.581E-2 2 12
10 C1839025 Decreased amplitudes on flash visual electroretinogram DisGeNET Curated 8.025E-5 4.229E-3 2.895E-2 4.229E-2 2 13
11 C0238286 Mucolipidosis Type IV DisGeNET Curated 1.079E-4 4.249E-3 2.908E-2
5.686E-2
 2 15
12 C0029124 Optic Atrophy DisGeNET Curated 1.124E-4 4.249E-3 2.908E-2
5.922E-2
 4 250
13 C3278975 Attenuation of retinal blood vessels DisGeNET Curated 1.232E-4 4.249E-3 2.908E-2
6.494E-2
 2 16
14 C4024756 Abnormality of macular pigmentation DisGeNET Curated 1.232E-4 4.249E-3 2.908E-2
6.494E-2
 2 16
15 C1837087 Macular pigmentary changes DisGeNET Curated 1.232E-4 4.249E-3 2.908E-2
6.494E-2
 2 16
16 C0476397 Electroretinogram abnormal DisGeNET Curated 1.290E-4 4.249E-3 2.908E-2
6.798E-2
 3 96
17 C0029089 Ophthalmoplegia DisGeNET Curated 1.683E-4 5.008E-3 3.428E-2
8.867E-2
 3 105
18 C0085580 Essential Hypertension DisGeNET Curated 1.836E-4 5.008E-3 3.428E-2
9.675E-2
 4 284
19 C0456909 Blind Vision DisGeNET Curated 1.983E-4 5.008E-3 3.428E-2
1.045E-1
 3 111
20 C0271215 Blindness, Legal DisGeNET Curated 1.983E-4 5.008E-3 3.428E-2
1.045E-1
 3 111
21 C1720508 Retinal pigment epithelial abnormality DisGeNET Curated 2.091E-4 5.008E-3 3.428E-2
1.102E-1
 3 113
22 C1862475 Abnormality of retinal pigmentation DisGeNET Curated 2.091E-4 5.008E-3 3.428E-2
1.102E-1
 3 113
23 C0022578 Keratoconus DisGeNET Curated 2.317E-4 5.308E-3 3.634E-2
1.221E-1
 3 117
24 C4020887 Photodysphoria DisGeNET Curated 2.621E-4 5.755E-3 3.940E-2
1.381E-1
 3 122
25 C0018777 Conductive hearing loss DisGeNET Curated 2.882E-4 5.921E-3 4.053E-2
1.519E-1
 3 126
26 C0600040 Chronic interstitial cystitis DisGeNET BeFree 3.064E-4 5.921E-3 4.053E-2
1.615E-1
 2 25
27 C0085636 Photophobia DisGeNET Curated 3.089E-4 5.921E-3 4.053E-2
1.628E-1
 3 129
28 C0020459 Hyperinsulinism DisGeNET Curated 3.147E-4 5.921E-3 4.053E-2
1.659E-1
 4 327
29 C0035309 Retinal Diseases DisGeNET Curated 3.258E-4 5.921E-3 4.053E-2
1.717E-1
 4 330
30 C0020619 Hypogonadism DisGeNET Curated 3.927E-4 6.899E-3 4.722E-2
2.070E-1
 3 140
31 C0085159 Seasonal Affective Disorder DisGeNET Curated 5.044E-4 8.130E-3
5.565E-2
2.658E-1
 2 32
32 C0235095 Visual field constriction DisGeNET Curated 6.390E-4 8.130E-3
5.565E-2
3.368E-1
 2 36
33 C0206733 Strawberry nevus of skin DisGeNET Curated 6.751E-4 8.130E-3
5.565E-2
3.558E-1
 2 37
34 C0266435 Congenital hypoplasia of penis DisGeNET Curated 8.710E-4 8.130E-3
5.565E-2
4.590E-1
 3 184
35 C1840077 Anteverted nostril DisGeNET Curated 9.704E-4 8.130E-3
5.565E-2
5.114E-1
 3 191
36 C0282488 Interstitial Cystitis DisGeNET Curated 9.986E-4 8.130E-3
5.565E-2
5.263E-1
 2 45
37 C0024437 Macular degeneration DisGeNET Curated 1.043E-3 8.130E-3
5.565E-2
5.499E-1
 2 46
38 C1306247 Melanotic neurilemmoma DisGeNET BeFree 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
39 OMIN:153800 MACULAR DEGENERATION, AGE-RELATED, 2; ARMD2 OMIM 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
40 C1272174 Scotopic sensitivity DisGeNET BeFree 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
41 cv:CN031413 Age-related macular degeneration 2 Clinical Variations 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
42 OMIN:601718 RETINITIS PIGMENTOSA 19; RP19 OMIM 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
43 C0542302 Blood Pressure Disorders DisGeNET BeFree 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
44 cv:C0038505 Sturge-Weber syndrome Clinical Variations 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
45 C3495438 Macular Degeneration, Age-Related, 2 DisGeNET Curated 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
46 OMIN:604116 CONE-ROD DYSTROPHY 3; CORD3 OMIM 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
47 C0346390 Hemangioma of choroid DisGeNET Curated 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
48 cv:C1864869 Congenital stationary night blindness, autosomal dominant 1 Clinical Variations 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
49 OMIN:610445 NIGHT BLINDNESS, CONGENITAL STATIONARY, AUTOSOMAL DOMINANT 1; CSNBAD1 OMIM 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
50 C3553886 MICROCEPHALY 9, PRIMARY, AUTOSOMAL RECESSIVE DisGeNET Curated 1.049E-3 8.130E-3
5.565E-2
5.529E-1
 1 1
Show 45 more annotations